id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-335172-5ig907on	Busse, Laurence W.	COVID-19 and the RAAS—a potential role for angiotensin II?	2020-04-07		.txt	text/plain	1668	106	52	Likewise, patients on angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB) could be at a greater risk due to the mechanism by which SARS-CoV-2 enters the cell. First, because it normally binds to ACE2 during its degradation and hydrolysis into angiotensin-(1-7) [11] , it may compete with the SARS-CoV-2 for the ACE2 receptor (Fig. 1) . Second, the binding of AngII to the AT1 receptor has been shown to cause internalization and downregulation of ACE2 through an ERK1/2 and p38 MAP kinase pathway in both in vitro animal and in vivo human models [12, 13] . However, to date, the link between ACE inhibitors and ARBs and severity of illness of SARS-CoV-2 infection is purely speculative. Ang-2, angiotensin II; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; ACE1, angiotensinconverting-enzyme 1; ACE2, angiotensin-converting-enzyme 2; H 2 O, water; Na + , sodium Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus	./cache/cord-335172-5ig907on.txt	./txt/cord-335172-5ig907on.txt