key: cord-344027-qghktrm1
authors: Fiolet, Thibault; Guihur, Anthony; Rebeaud, Mathieu E.; Mulot, Matthieu; Peiffer-Smadja, Nathan; Mahamat-Saleh, Yahya
title: 'Effect of hydroxychloroquine with or without azithromycin on the mortality of COVID-19 patients' – Author’s reply
date: 2020-10-17
journal: Clin Microbiol Infect
DOI: 10.1016/j.cmi.2020.10.002
sha: 
doc_id: 344027
cord_uid: qghktrm1

nan

3) There is a high imbalance between groups for age and comorbidities, factors associated 47 with a poorer outcome. Moreover, patients with contraindications to HCQ or AZI were 48 included in the control group, while they should have been excluded from the comparison. 49

As with all studies at risk of critical bias included in our systematic review, it was excluded 50 from the main analysis. A sensitivity analysis including studies at risk of critical bias was 51 performed, which only marginally modified our results (Supplementary table S6 The statement that we used "subjective and specious" inclusion criteria is wrong. 

The 150 PRISMA statement for reporting systematic reviews and meta-analyses of studies that 151 evaluate healthcare interventions: explanation and elaboration

Treatment 154 with hydroxychloroquine, azithromycin, and combination in patients hospitalized with

Clinical 158 Efficacy of Chloroquine derivatives in COVID-19 Infection: Comparative meta-analysis 159 between the Big data and the real world

Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19. Annals of Internal 163 Medicine 2020

Hydroxychloroquine in Hospitalized Patients with COVID-19: Preliminary results from a 166 multi-centre, randomized, controlled trial

COVID-19 177 prevention and treatment: A critical analysis of chloroquine and hydroxychloroquine 178 clinical pharmacology

Concentration-dependent mortality of chloroquine in overdose

Utilization 184 of COVID-19 treatments and clinical outcomes among patients with cancer: A COVID-185 19 and Cancer Consortium (CCC19) cohort study

Interventions 188 for treatment of COVID-19: A living systematic review with meta-analyses and trial 189 sequential analyses (The LIVING Project)

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19: an 193 international collaborative meta-analysis of randomized trials

Hydroxychloroquine as pre-exposure prophylaxis for COVID-19 in healthcare workers: 203 a randomized trial