id sid tid token lemma pos cord-318358-glbr8kxh 1 1 key key NN cord-318358-glbr8kxh 1 2 : : : cord-318358-glbr8kxh 2 1 cord-318358-glbr8kxh cord-318358-glbr8kxh JJ cord-318358-glbr8kxh 2 2 authors author NNS cord-318358-glbr8kxh 2 3 : : : cord-318358-glbr8kxh 2 4 Naik Naik NNP cord-318358-glbr8kxh 2 5 , , , cord-318358-glbr8kxh 2 6 George George NNP cord-318358-glbr8kxh 2 7 O O NNP cord-318358-glbr8kxh 3 1 A a DT cord-318358-glbr8kxh 3 2 title title NN cord-318358-glbr8kxh 3 3 : : : cord-318358-glbr8kxh 3 4 COVID-19 covid-19 VB cord-318358-glbr8kxh 3 5 and and CC cord-318358-glbr8kxh 3 6 the the DT cord-318358-glbr8kxh 3 7 RAAS RAAS NNP cord-318358-glbr8kxh 3 8 date date NN cord-318358-glbr8kxh 3 9 : : : cord-318358-glbr8kxh 3 10 2020 2020 CD cord-318358-glbr8kxh 3 11 - - HYPH cord-318358-glbr8kxh 3 12 06 06 CD cord-318358-glbr8kxh 3 13 - - SYM cord-318358-glbr8kxh 3 14 20 20 CD cord-318358-glbr8kxh 3 15 journal journal NN cord-318358-glbr8kxh 3 16 : : : cord-318358-glbr8kxh 4 1 Clin Clin NNP cord-318358-glbr8kxh 4 2 Infect infect VB cord-318358-glbr8kxh 4 3 Dis Dis NNP cord-318358-glbr8kxh 4 4 DOI doi NN cord-318358-glbr8kxh 4 5 : : : cord-318358-glbr8kxh 4 6 10.1093 10.1093 CD cord-318358-glbr8kxh 4 7 / / SYM cord-318358-glbr8kxh 4 8 cid cid NN cord-318358-glbr8kxh 4 9 / / SYM cord-318358-glbr8kxh 4 10 ciaa818 ciaa818 NNP cord-318358-glbr8kxh 5 1 sha sha NNP cord-318358-glbr8kxh 5 2 : : : cord-318358-glbr8kxh 6 1 8ba65f299736f82f3090fe58cc2bc2f9279774bf 8ba65f299736f82f3090fe58cc2bc2f9279774bf CD cord-318358-glbr8kxh 7 1 doc_id doc_id CD cord-318358-glbr8kxh 7 2 : : : cord-318358-glbr8kxh 8 1 318358 318358 CD cord-318358-glbr8kxh 8 2 cord_uid cord_uid NNS cord-318358-glbr8kxh 8 3 : : : cord-318358-glbr8kxh 8 4 glbr8kxh glbr8kxh VBP cord-318358-glbr8kxh 8 5 nan nan NNP cord-318358-glbr8kxh 8 6 M M NNP cord-318358-glbr8kxh 8 7 a a NNP cord-318358-glbr8kxh 8 8 n n NN cord-318358-glbr8kxh 8 9 u u NNP cord-318358-glbr8kxh 8 10 s s NN cord-318358-glbr8kxh 8 11 c c NN cord-318358-glbr8kxh 8 12 r r NN cord-318358-glbr8kxh 9 1 i i NN cord-318358-glbr8kxh 9 2 p p NN cord-318358-glbr8kxh 9 3 t t NN cord-318358-glbr8kxh 10 1 Dear Dear NNP cord-318358-glbr8kxh 10 2 Editor Editor NNP cord-318358-glbr8kxh 10 3 : : : cord-318358-glbr8kxh 11 1 Further further RB cord-318358-glbr8kxh 11 2 to to IN cord-318358-glbr8kxh 11 3 Thomas Thomas NNP cord-318358-glbr8kxh 11 4 Hanff Hanff NNP cord-318358-glbr8kxh 12 1 et et NNP cord-318358-glbr8kxh 12 2 al al NNP cord-318358-glbr8kxh 12 3 [ [ -LRB- cord-318358-glbr8kxh 12 4 1 1 CD cord-318358-glbr8kxh 12 5 ] ] -RRB- cord-318358-glbr8kxh 13 1 timely timely RB cord-318358-glbr8kxh 13 2 call call NN cord-318358-glbr8kxh 13 3 for for IN cord-318358-glbr8kxh 13 4 epidemiological epidemiological JJ cord-318358-glbr8kxh 13 5 and and CC cord-318358-glbr8kxh 13 6 clinical clinical JJ cord-318358-glbr8kxh 13 7 investigations investigation NNS cord-318358-glbr8kxh 13 8 of of IN cord-318358-glbr8kxh 13 9 COVID-19 covid-19 JJ cord-318358-glbr8kxh 13 10 infectious infectious JJ cord-318358-glbr8kxh 13 11 disease disease NN cord-318358-glbr8kxh 13 12 , , , cord-318358-glbr8kxh 13 13 measurements measurement NNS cord-318358-glbr8kxh 13 14 of of IN cord-318358-glbr8kxh 13 15 the the DT cord-318358-glbr8kxh 13 16 renin renin NNP cord-318358-glbr8kxh 13 17 angiotensin angiotensin NNP cord-318358-glbr8kxh 13 18 aldosterone aldosterone NNP cord-318358-glbr8kxh 13 19 system system NN cord-318358-glbr8kxh 13 20 ( ( -LRB- cord-318358-glbr8kxh 13 21 RAAS RAAS NNP cord-318358-glbr8kxh 13 22 ) ) -RRB- cord-318358-glbr8kxh 13 23 components component NNS cord-318358-glbr8kxh 13 24 , , , cord-318358-glbr8kxh 13 25 as as IN cord-318358-glbr8kxh 13 26 sub sub NN cord-318358-glbr8kxh 13 27 - - NNS cord-318358-glbr8kxh 13 28 studies study NNS cord-318358-glbr8kxh 13 29 would would MD cord-318358-glbr8kxh 13 30 be be VB cord-318358-glbr8kxh 13 31 insightful insightful JJ cord-318358-glbr8kxh 13 32 of of IN cord-318358-glbr8kxh 13 33 this this DT cord-318358-glbr8kxh 13 34 pandemic pandemic NN cord-318358-glbr8kxh 13 35 . . . cord-318358-glbr8kxh 14 1 Angiotensin angiotensin NN cord-318358-glbr8kxh 14 2 - - HYPH cord-318358-glbr8kxh 14 3 converting convert VBG cord-318358-glbr8kxh 14 4 enzyme enzyme NN cord-318358-glbr8kxh 14 5 2 2 CD cord-318358-glbr8kxh 14 6 ( ( -LRB- cord-318358-glbr8kxh 14 7 ACE ACE NNP cord-318358-glbr8kxh 14 8 2 2 CD cord-318358-glbr8kxh 14 9 ) ) -RRB- cord-318358-glbr8kxh 14 10 participates participate VBZ cord-318358-glbr8kxh 14 11 in in IN cord-318358-glbr8kxh 14 12 the the DT cord-318358-glbr8kxh 14 13 coronavirus coronavirus NN cord-318358-glbr8kxh 14 14 ( ( -LRB- cord-318358-glbr8kxh 14 15 SARS SARS NNP cord-318358-glbr8kxh 14 16 - - HYPH cord-318358-glbr8kxh 14 17 CoV-2 CoV-2 NNP cord-318358-glbr8kxh 14 18 ) ) -RRB- cord-318358-glbr8kxh 14 19 cell cell NN cord-318358-glbr8kxh 14 20 entry entry NN cord-318358-glbr8kxh 14 21 . . . cord-318358-glbr8kxh 15 1 This this DT cord-318358-glbr8kxh 15 2 infection infection NN cord-318358-glbr8kxh 15 3 down down RP cord-318358-glbr8kxh 15 4 regulates regulate VBZ cord-318358-glbr8kxh 15 5 ACE ace NN cord-318358-glbr8kxh 15 6 2 2 CD cord-318358-glbr8kxh 15 7 . . . cord-318358-glbr8kxh 16 1 Drugs drug NNS cord-318358-glbr8kxh 16 2 that that WDT cord-318358-glbr8kxh 16 3 block block VBP cord-318358-glbr8kxh 16 4 RAAS RAAS NNP cord-318358-glbr8kxh 16 5 also also RB cord-318358-glbr8kxh 16 6 affect affect VBP cord-318358-glbr8kxh 16 7 ACE ace NN cord-318358-glbr8kxh 16 8 2 2 CD cord-318358-glbr8kxh 16 9 expression expression NN cord-318358-glbr8kxh 16 10 : : : cord-318358-glbr8kxh 17 1 it -PRON- PRP cord-318358-glbr8kxh 17 2 is be VBZ cord-318358-glbr8kxh 17 3 down down RB cord-318358-glbr8kxh 17 4 regulated regulate VBN cord-318358-glbr8kxh 17 5 by by IN cord-318358-glbr8kxh 17 6 renin renin NN cord-318358-glbr8kxh 17 7 inhibition inhibition NN cord-318358-glbr8kxh 17 8 ( ( -LRB- cord-318358-glbr8kxh 17 9 RI RI NNP cord-318358-glbr8kxh 17 10 ) ) -RRB- cord-318358-glbr8kxh 17 11 and and CC cord-318358-glbr8kxh 17 12 up up RB cord-318358-glbr8kxh 17 13 regulated regulate VBN cord-318358-glbr8kxh 17 14 by by IN cord-318358-glbr8kxh 17 15 angiotensin angiotensin NN cord-318358-glbr8kxh 17 16 - - HYPH cord-318358-glbr8kxh 17 17 converting convert VBG cord-318358-glbr8kxh 17 18 enzyme enzyme NN cord-318358-glbr8kxh 17 19 inhibitors inhibitor NNS cord-318358-glbr8kxh 17 20 ( ( -LRB- cord-318358-glbr8kxh 17 21 ACEIs acei NNS cord-318358-glbr8kxh 17 22 ) ) -RRB- cord-318358-glbr8kxh 17 23 , , , cord-318358-glbr8kxh 17 24 angiotensin angiotensin NN cord-318358-glbr8kxh 17 25 receptor receptor NN cord-318358-glbr8kxh 17 26 blockers blocker NNS cord-318358-glbr8kxh 17 27 ( ( -LRB- cord-318358-glbr8kxh 17 28 ARBs arb NNS cord-318358-glbr8kxh 17 29 ) ) -RRB- cord-318358-glbr8kxh 17 30 ( ( -LRB- cord-318358-glbr8kxh 17 31 1 1 CD cord-318358-glbr8kxh 17 32 ) ) -RRB- cord-318358-glbr8kxh 17 33 and and CC cord-318358-glbr8kxh 17 34 mineralocorticoid mineralocorticoid NN cord-318358-glbr8kxh 17 35 receptor receptor NN cord-318358-glbr8kxh 17 36 antagonists antagonist NNS cord-318358-glbr8kxh 17 37 ( ( -LRB- cord-318358-glbr8kxh 17 38 MRAs mra NNS cord-318358-glbr8kxh 17 39 ) ) -RRB- cord-318358-glbr8kxh 17 40 [ [ -LRB- cord-318358-glbr8kxh 17 41 2 2 CD cord-318358-glbr8kxh 17 42 ] ] -RRB- cord-318358-glbr8kxh 17 43 . . . cord-318358-glbr8kxh 18 1 Other other JJ cord-318358-glbr8kxh 18 2 likely likely JJ cord-318358-glbr8kxh 18 3 regulatory regulatory JJ cord-318358-glbr8kxh 18 4 factors factor NNS cord-318358-glbr8kxh 18 5 are be VBP cord-318358-glbr8kxh 18 6 age age NN cord-318358-glbr8kxh 18 7 , , , cord-318358-glbr8kxh 18 8 type type NN cord-318358-glbr8kxh 18 9 II ii CD cord-318358-glbr8kxh 18 10 diabetes diabetes NN cord-318358-glbr8kxh 18 11 and and CC cord-318358-glbr8kxh 18 12 sex sex NN cord-318358-glbr8kxh 18 13 difference difference NN cord-318358-glbr8kxh 18 14 [ [ -LRB- cord-318358-glbr8kxh 18 15 3 3 CD cord-318358-glbr8kxh 18 16 ] ] -RRB- cord-318358-glbr8kxh 18 17 . . . cord-318358-glbr8kxh 19 1 These these DT cord-318358-glbr8kxh 19 2 interactions interaction NNS cord-318358-glbr8kxh 19 3 would would MD cord-318358-glbr8kxh 19 4 directly directly RB cord-318358-glbr8kxh 19 5 affect affect VB cord-318358-glbr8kxh 19 6 the the DT cord-318358-glbr8kxh 19 7 balance balance NN cord-318358-glbr8kxh 19 8 between between IN cord-318358-glbr8kxh 19 9 the the DT cord-318358-glbr8kxh 19 10 beneficial beneficial JJ cord-318358-glbr8kxh 19 11 and and CC cord-318358-glbr8kxh 19 12 deleterious deleterious JJ cord-318358-glbr8kxh 19 13 angiotensins angiotensin NNS cord-318358-glbr8kxh 19 14 ( ( -LRB- cord-318358-glbr8kxh 19 15 Angs Angs NNP cord-318358-glbr8kxh 19 16 ) ) -RRB- cord-318358-glbr8kxh 19 17 , , , cord-318358-glbr8kxh 19 18 such such JJ cord-318358-glbr8kxh 19 19 as as IN cord-318358-glbr8kxh 19 20 , , , cord-318358-glbr8kxh 19 21 Ang Ang NNP cord-318358-glbr8kxh 19 22 ( ( -LRB- cord-318358-glbr8kxh 19 23 1 1 CD cord-318358-glbr8kxh 19 24 - - SYM cord-318358-glbr8kxh 19 25 7 7 CD cord-318358-glbr8kxh 19 26 ) ) -RRB- cord-318358-glbr8kxh 19 27 and and CC cord-318358-glbr8kxh 19 28 Ang Ang NNP cord-318358-glbr8kxh 19 29 ( ( -LRB- cord-318358-glbr8kxh 19 30 1 1 CD cord-318358-glbr8kxh 19 31 - - SYM cord-318358-glbr8kxh 19 32 9 9 CD cord-318358-glbr8kxh 19 33 ) ) -RRB- cord-318358-glbr8kxh 19 34 versus versus IN cord-318358-glbr8kxh 19 35 excess excess JJ cord-318358-glbr8kxh 19 36 Ang Ang NNP cord-318358-glbr8kxh 19 37 II II NNP cord-318358-glbr8kxh 19 38 . . . cord-318358-glbr8kxh 20 1 Such such JJ cord-318358-glbr8kxh 20 2 perturbations perturbation NNS cord-318358-glbr8kxh 20 3 would would MD cord-318358-glbr8kxh 20 4 also also RB cord-318358-glbr8kxh 20 5 indirectly indirectly RB cord-318358-glbr8kxh 20 6 influence influence VB cord-318358-glbr8kxh 20 7 other other JJ cord-318358-glbr8kxh 20 8 RAAS RAAS NNP cord-318358-glbr8kxh 20 9 components component NNS cord-318358-glbr8kxh 20 10 , , , cord-318358-glbr8kxh 20 11 and and CC cord-318358-glbr8kxh 20 12 the the DT cord-318358-glbr8kxh 20 13 coordination coordination NN cord-318358-glbr8kxh 20 14 between between IN cord-318358-glbr8kxh 20 15 circulating circulate VBG cord-318358-glbr8kxh 20 16 and and CC cord-318358-glbr8kxh 20 17 local local JJ cord-318358-glbr8kxh 20 18 tissue tissue NN cord-318358-glbr8kxh 20 19 expressions expression NNS cord-318358-glbr8kxh 20 20 , , , cord-318358-glbr8kxh 20 21 as as IN cord-318358-glbr8kxh 20 22 shown show VBN cord-318358-glbr8kxh 20 23 in in IN cord-318358-glbr8kxh 20 24 Figure figure NN cord-318358-glbr8kxh 20 25 1 1 CD cord-318358-glbr8kxh 20 26 ACE ace NN cord-318358-glbr8kxh 20 27 2 2 CD cord-318358-glbr8kxh 20 28 is be VBZ cord-318358-glbr8kxh 20 29 distributed distribute VBN cord-318358-glbr8kxh 20 30 throughout throughout IN cord-318358-glbr8kxh 20 31 the the DT cord-318358-glbr8kxh 20 32 body body NN cord-318358-glbr8kxh 20 33 and and CC cord-318358-glbr8kxh 20 34 is be VBZ cord-318358-glbr8kxh 20 35 abundantly abundantly RB cord-318358-glbr8kxh 20 36 expressed express VBN cord-318358-glbr8kxh 20 37 in in IN cord-318358-glbr8kxh 20 38 the the DT cord-318358-glbr8kxh 20 39 lung lung NN cord-318358-glbr8kxh 20 40 , , , cord-318358-glbr8kxh 20 41 small small JJ cord-318358-glbr8kxh 20 42 intestine intestine NN cord-318358-glbr8kxh 20 43 , , , cord-318358-glbr8kxh 20 44 and and CC cord-318358-glbr8kxh 20 45 in in IN cord-318358-glbr8kxh 20 46 blood blood NN cord-318358-glbr8kxh 20 47 vessels vessel NNS cord-318358-glbr8kxh 20 48 of of IN cord-318358-glbr8kxh 20 49 many many JJ cord-318358-glbr8kxh 20 50 organs organ NNS cord-318358-glbr8kxh 20 51 including include VBG cord-318358-glbr8kxh 20 52 the the DT cord-318358-glbr8kxh 20 53 brain brain NN cord-318358-glbr8kxh 20 54 , , , cord-318358-glbr8kxh 20 55 heart heart NN cord-318358-glbr8kxh 20 56 , , , cord-318358-glbr8kxh 20 57 kidney kidney NN cord-318358-glbr8kxh 20 58 and and CC cord-318358-glbr8kxh 20 59 testis testis NN cord-318358-glbr8kxh 20 60 [ [ -LRB- cord-318358-glbr8kxh 20 61 4 4 CD cord-318358-glbr8kxh 20 62 ] ] -RRB- cord-318358-glbr8kxh 20 63 . . . cord-318358-glbr8kxh 21 1 These these DT cord-318358-glbr8kxh 21 2 organs organ NNS cord-318358-glbr8kxh 21 3 and and CC cord-318358-glbr8kxh 21 4 blood blood NN cord-318358-glbr8kxh 21 5 vessels vessel NNS cord-318358-glbr8kxh 21 6 are be VBP cord-318358-glbr8kxh 21 7 potential potential JJ cord-318358-glbr8kxh 21 8 sites site NNS cord-318358-glbr8kxh 21 9 of of IN cord-318358-glbr8kxh 21 10 infection infection NN cord-318358-glbr8kxh 21 11 . . . cord-318358-glbr8kxh 22 1 The the DT cord-318358-glbr8kxh 22 2 downregulation downregulation NN cord-318358-glbr8kxh 22 3 of of IN cord-318358-glbr8kxh 22 4 ACE ace NN cord-318358-glbr8kxh 22 5 2 2 CD cord-318358-glbr8kxh 22 6 would would MD cord-318358-glbr8kxh 22 7 reduce reduce VB cord-318358-glbr8kxh 22 8 the the DT cord-318358-glbr8kxh 22 9 production production NN cord-318358-glbr8kxh 22 10 of of IN cord-318358-glbr8kxh 22 11 Ang Ang NNP cord-318358-glbr8kxh 22 12 ( ( -LRB- cord-318358-glbr8kxh 22 13 1 1 CD cord-318358-glbr8kxh 22 14 - - SYM cord-318358-glbr8kxh 22 15 7 7 CD cord-318358-glbr8kxh 22 16 ) ) -RRB- cord-318358-glbr8kxh 22 17 and and CC cord-318358-glbr8kxh 22 18 Ang Ang NNP cord-318358-glbr8kxh 22 19 ( ( -LRB- cord-318358-glbr8kxh 22 20 1 1 CD cord-318358-glbr8kxh 22 21 - - SYM cord-318358-glbr8kxh 22 22 9 9 CD cord-318358-glbr8kxh 22 23 ) ) -RRB- cord-318358-glbr8kxh 22 24 , , , cord-318358-glbr8kxh 22 25 and and CC cord-318358-glbr8kxh 22 26 concurrently concurrently RB cord-318358-glbr8kxh 22 27 prevent prevent VB cord-318358-glbr8kxh 22 28 the the DT cord-318358-glbr8kxh 22 29 reduction reduction NN cord-318358-glbr8kxh 22 30 of of IN cord-318358-glbr8kxh 22 31 the the DT cord-318358-glbr8kxh 22 32 Ang Ang NNP cord-318358-glbr8kxh 22 33 II II NNP cord-318358-glbr8kxh 22 34 , , , cord-318358-glbr8kxh 22 35 tilting tilt VBG cord-318358-glbr8kxh 22 36 the the DT cord-318358-glbr8kxh 22 37 balance balance NN cord-318358-glbr8kxh 22 38 to to IN cord-318358-glbr8kxh 22 39 Ang Ang NNP cord-318358-glbr8kxh 22 40 II II NNP cord-318358-glbr8kxh 22 41 accumulation accumulation NN cord-318358-glbr8kxh 22 42 that that WDT cord-318358-glbr8kxh 22 43 may may MD cord-318358-glbr8kxh 22 44 lead lead VB cord-318358-glbr8kxh 22 45 to to IN cord-318358-glbr8kxh 22 46 toxicity toxicity NN cord-318358-glbr8kxh 22 47 [ [ -LRB- cord-318358-glbr8kxh 22 48 1 1 CD cord-318358-glbr8kxh 22 49 ] ] -RRB- cord-318358-glbr8kxh 22 50 , , , cord-318358-glbr8kxh 22 51 Figure figure NN cord-318358-glbr8kxh 22 52 1 1 CD cord-318358-glbr8kxh 22 53 ( ( -LRB- cord-318358-glbr8kxh 22 54 b b NN cord-318358-glbr8kxh 22 55 ) ) -RRB- cord-318358-glbr8kxh 22 56 . . . cord-318358-glbr8kxh 23 1 Such such JJ cord-318358-glbr8kxh 23 2 dysregulation dysregulation NN cord-318358-glbr8kxh 23 3 likely likely RB cord-318358-glbr8kxh 23 4 contributed contribute VBD cord-318358-glbr8kxh 23 5 to to IN cord-318358-glbr8kxh 23 6 reported report VBN cord-318358-glbr8kxh 23 7 cases case NNS cord-318358-glbr8kxh 23 8 of of IN cord-318358-glbr8kxh 23 9 acute acute JJ cord-318358-glbr8kxh 23 10 respiratory respiratory JJ cord-318358-glbr8kxh 23 11 distress distress NN cord-318358-glbr8kxh 23 12 syndrome syndrome NN cord-318358-glbr8kxh 23 13 ( ( -LRB- cord-318358-glbr8kxh 23 14 ARDS ARDS NNP cord-318358-glbr8kxh 23 15 ) ) -RRB- cord-318358-glbr8kxh 23 16 [ [ -LRB- cord-318358-glbr8kxh 23 17 1 1 CD cord-318358-glbr8kxh 23 18 ] ] -RRB- cord-318358-glbr8kxh 23 19 , , . cord-318358-glbr8kxh 24 1 A a DT cord-318358-glbr8kxh 24 2 c c NN cord-318358-glbr8kxh 24 3 c c NN cord-318358-glbr8kxh 24 4 e e NN cord-318358-glbr8kxh 24 5 p p NN cord-318358-glbr8kxh 24 6 t t NN cord-318358-glbr8kxh 24 7 e e NN cord-318358-glbr8kxh 24 8 d d NNP cord-318358-glbr8kxh 24 9 M M NNP cord-318358-glbr8kxh 24 10 a a NNP cord-318358-glbr8kxh 24 11 n n NN cord-318358-glbr8kxh 24 12 u u NNP cord-318358-glbr8kxh 24 13 s s NNP cord-318358-glbr8kxh 24 14 c c NN cord-318358-glbr8kxh 24 15 r r NN cord-318358-glbr8kxh 24 16 i i NN cord-318358-glbr8kxh 24 17 p p NN cord-318358-glbr8kxh 24 18 t t NN cord-318358-glbr8kxh 24 19 inflammation inflammation NN cord-318358-glbr8kxh 24 20 , , , cord-318358-glbr8kxh 24 21 myocardial myocardial JJ cord-318358-glbr8kxh 24 22 injury injury NN cord-318358-glbr8kxh 24 23 [ [ -LRB- cord-318358-glbr8kxh 24 24 5 5 CD cord-318358-glbr8kxh 24 25 ] ] -RRB- cord-318358-glbr8kxh 24 26 , , , cord-318358-glbr8kxh 24 27 neurological neurological JJ cord-318358-glbr8kxh 24 28 incidences incidence NNS cord-318358-glbr8kxh 24 29 [ [ -LRB- cord-318358-glbr8kxh 24 30 6 6 CD cord-318358-glbr8kxh 24 31 ] ] -RRB- cord-318358-glbr8kxh 24 32 and and CC cord-318358-glbr8kxh 24 33 gastrointestinal gastrointestinal JJ cord-318358-glbr8kxh 24 34 manifestations manifestation NNS cord-318358-glbr8kxh 24 35 [ [ -LRB- cord-318358-glbr8kxh 24 36 7 7 CD cord-318358-glbr8kxh 24 37 ] ] -RRB- cord-318358-glbr8kxh 24 38 . . . cord-318358-glbr8kxh 25 1 Other other JJ cord-318358-glbr8kxh 25 2 components component NNS cord-318358-glbr8kxh 25 3 and and CC cord-318358-glbr8kxh 25 4 the the DT cord-318358-glbr8kxh 25 5 crosstalk crosstalk NN cord-318358-glbr8kxh 25 6 between between IN cord-318358-glbr8kxh 25 7 the the DT cord-318358-glbr8kxh 25 8 systemic systemic JJ cord-318358-glbr8kxh 25 9 circulation circulation NN cord-318358-glbr8kxh 25 10 and and CC cord-318358-glbr8kxh 25 11 local local JJ cord-318358-glbr8kxh 25 12 tissue tissue NN cord-318358-glbr8kxh 25 13 renin renin NN cord-318358-glbr8kxh 25 14 angiotensin angiotensin NN cord-318358-glbr8kxh 25 15 system system NN cord-318358-glbr8kxh 25 16 would would MD cord-318358-glbr8kxh 25 17 also also RB cord-318358-glbr8kxh 25 18 be be VB cord-318358-glbr8kxh 25 19 disrupted disrupt VBN cord-318358-glbr8kxh 25 20 . . . cord-318358-glbr8kxh 26 1 Changes change NNS cord-318358-glbr8kxh 26 2 in in IN cord-318358-glbr8kxh 26 3 circulating circulate VBG cord-318358-glbr8kxh 26 4 Ang Ang NNP cord-318358-glbr8kxh 26 5 II II NNP cord-318358-glbr8kxh 26 6 concentration concentration NN cord-318358-glbr8kxh 26 7 alter alter VB cord-318358-glbr8kxh 26 8 renin renin NN cord-318358-glbr8kxh 26 9 secretion secretion NN cord-318358-glbr8kxh 26 10 through through IN cord-318358-glbr8kxh 26 11 a a DT cord-318358-glbr8kxh 26 12 negative negative JJ cord-318358-glbr8kxh 26 13 feedback feedback NN cord-318358-glbr8kxh 26 14 loop loop NN cord-318358-glbr8kxh 26 15 , , , cord-318358-glbr8kxh 26 16 Figure figure NN cord-318358-glbr8kxh 26 17 1 1 CD cord-318358-glbr8kxh 26 18 ( ( -LRB- cord-318358-glbr8kxh 26 19 a a NN cord-318358-glbr8kxh 26 20 ) ) -RRB- cord-318358-glbr8kxh 26 21 , , , cord-318358-glbr8kxh 26 22 as as IN cord-318358-glbr8kxh 26 23 Ang Ang NNP cord-318358-glbr8kxh 26 24 II II NNP cord-318358-glbr8kxh 26 25 decreases decrease VBZ cord-318358-glbr8kxh 26 26 renin renin NN cord-318358-glbr8kxh 26 27 secretion secretion NN cord-318358-glbr8kxh 26 28 increases increase NNS cord-318358-glbr8kxh 26 29 and and CC cord-318358-glbr8kxh 26 30 consequently consequently RB cord-318358-glbr8kxh 26 31 affect affect VBP cord-318358-glbr8kxh 26 32 renin renin NN cord-318358-glbr8kxh 26 33 concentration concentration NN cord-318358-glbr8kxh 26 34 and and CC cord-318358-glbr8kxh 26 35 plasma plasma NN cord-318358-glbr8kxh 26 36 renin renin NN cord-318358-glbr8kxh 26 37 activity activity NN cord-318358-glbr8kxh 26 38 ( ( -LRB- cord-318358-glbr8kxh 26 39 PRA PRA NNP cord-318358-glbr8kxh 26 40 ) ) -RRB- cord-318358-glbr8kxh 26 41 . . . cord-318358-glbr8kxh 27 1 Renin renin NN cord-318358-glbr8kxh 27 2 converts convert VBZ cord-318358-glbr8kxh 27 3 angiotensinogen angiotensinogen NNP cord-318358-glbr8kxh 27 4 to to IN cord-318358-glbr8kxh 27 5 angiotensin angiotensin NNP cord-318358-glbr8kxh 28 1 I -PRON- PRP cord-318358-glbr8kxh 28 2 ( ( -LRB- cord-318358-glbr8kxh 28 3 Ang Ang NNP cord-318358-glbr8kxh 28 4 I I NNP cord-318358-glbr8kxh 28 5 ) ) -RRB- cord-318358-glbr8kxh 28 6 and and CC cord-318358-glbr8kxh 28 7 PRA PRA NNP cord-318358-glbr8kxh 28 8 is be VBZ cord-318358-glbr8kxh 28 9 a a DT cord-318358-glbr8kxh 28 10 measure measure NN cord-318358-glbr8kxh 28 11 of of IN cord-318358-glbr8kxh 28 12 this this DT cord-318358-glbr8kxh 28 13 rate rate NN cord-318358-glbr8kxh 28 14 . . . cord-318358-glbr8kxh 29 1 Renin renin NN cord-318358-glbr8kxh 29 2 catalytic catalytic JJ cord-318358-glbr8kxh 29 3 activity activity NN cord-318358-glbr8kxh 29 4 is be VBZ cord-318358-glbr8kxh 29 5 enhanced enhance VBN cord-318358-glbr8kxh 29 6 when when WRB cord-318358-glbr8kxh 29 7 bound bind VBN cord-318358-glbr8kxh 29 8 to to IN cord-318358-glbr8kxh 29 9 its -PRON- PRP$ cord-318358-glbr8kxh 29 10 receptor receptor NN cord-318358-glbr8kxh 29 11 ( ( -LRB- cord-318358-glbr8kxh 29 12 PPR ppr NN cord-318358-glbr8kxh 29 13 ) ) -RRB- cord-318358-glbr8kxh 30 1 [ [ -LRB- cord-318358-glbr8kxh 30 2 8 8 CD cord-318358-glbr8kxh 30 3 ] ] -RRB- cord-318358-glbr8kxh 30 4 . . . cord-318358-glbr8kxh 31 1 The the DT cord-318358-glbr8kxh 31 2 inhibition inhibition NN cord-318358-glbr8kxh 31 3 of of IN cord-318358-glbr8kxh 31 4 renin renin NN cord-318358-glbr8kxh 31 5 or or CC cord-318358-glbr8kxh 31 6 ACE ace NN cord-318358-glbr8kxh 31 7 reduces reduce VBZ cord-318358-glbr8kxh 31 8 circulating circulate VBG cord-318358-glbr8kxh 31 9 Ang Ang NNP cord-318358-glbr8kxh 31 10 II II NNP cord-318358-glbr8kxh 31 11 with with IN cord-318358-glbr8kxh 31 12 an an DT cord-318358-glbr8kxh 31 13 increase increase NN cord-318358-glbr8kxh 31 14 in in IN cord-318358-glbr8kxh 31 15 renin renin NN cord-318358-glbr8kxh 31 16 concentration concentration NN cord-318358-glbr8kxh 31 17 . . . cord-318358-glbr8kxh 32 1 It -PRON- PRP cord-318358-glbr8kxh 32 2 is be VBZ cord-318358-glbr8kxh 32 3 conceivable conceivable JJ cord-318358-glbr8kxh 32 4 that that IN cord-318358-glbr8kxh 32 5 circulating circulate VBG cord-318358-glbr8kxh 32 6 renin renin NN cord-318358-glbr8kxh 32 7 could could MD cord-318358-glbr8kxh 32 8 bind bind VB cord-318358-glbr8kxh 32 9 to to IN cord-318358-glbr8kxh 32 10 PPR PPR NNP cord-318358-glbr8kxh 32 11 , , , cord-318358-glbr8kxh 32 12 where where WRB cord-318358-glbr8kxh 32 13 expressed express VBN cord-318358-glbr8kxh 32 14 , , , cord-318358-glbr8kxh 32 15 and and CC cord-318358-glbr8kxh 32 16 activate activate VB cord-318358-glbr8kxh 32 17 local local JJ cord-318358-glbr8kxh 32 18 tissue tissue NN cord-318358-glbr8kxh 32 19 renin renin NN cord-318358-glbr8kxh 32 20 angiotensin angiotensin NN cord-318358-glbr8kxh 32 21 system system NN cord-318358-glbr8kxh 32 22 . . . cord-318358-glbr8kxh 33 1 Ang Ang NNP cord-318358-glbr8kxh 33 2 II II NNP cord-318358-glbr8kxh 33 3 changes change NNS cord-318358-glbr8kxh 33 4 would would MD cord-318358-glbr8kxh 33 5 also also RB cord-318358-glbr8kxh 33 6 affect affect VB cord-318358-glbr8kxh 33 7 aldosterone aldosterone NN cord-318358-glbr8kxh 33 8 stimulation stimulation NN cord-318358-glbr8kxh 33 9 and and CC cord-318358-glbr8kxh 33 10 angiotensin angiotensin NN cord-318358-glbr8kxh 33 11 IV IV NNP cord-318358-glbr8kxh 33 12 ( ( -LRB- cord-318358-glbr8kxh 33 13 Ang Ang NNP cord-318358-glbr8kxh 33 14 IV IV NNP cord-318358-glbr8kxh 33 15 ) ) -RRB- cord-318358-glbr8kxh 33 16 production production NN cord-318358-glbr8kxh 33 17 . . . cord-318358-glbr8kxh 34 1 Ang Ang NNP cord-318358-glbr8kxh 34 2 IV IV NNP cord-318358-glbr8kxh 34 3 through through IN cord-318358-glbr8kxh 34 4 its -PRON- PRP$ cord-318358-glbr8kxh 34 5 receptor receptor NN cord-318358-glbr8kxh 34 6 AT4 AT4 NNP cord-318358-glbr8kxh 34 7 has have VBZ cord-318358-glbr8kxh 34 8 opposite opposite JJ cord-318358-glbr8kxh 34 9 biological biological JJ cord-318358-glbr8kxh 34 10 effects effect NNS cord-318358-glbr8kxh 34 11 to to IN cord-318358-glbr8kxh 34 12 Ang Ang NNP cord-318358-glbr8kxh 34 13 II II NNP cord-318358-glbr8kxh 34 14 via via IN cord-318358-glbr8kxh 34 15 receptor receptor NN cord-318358-glbr8kxh 34 16 AT1 at1 NN cord-318358-glbr8kxh 34 17 . . . cord-318358-glbr8kxh 35 1 We -PRON- PRP cord-318358-glbr8kxh 35 2 therefore therefore RB cord-318358-glbr8kxh 35 3 suggest suggest VBP cord-318358-glbr8kxh 35 4 the the DT cord-318358-glbr8kxh 35 5 measurement measurement NN cord-318358-glbr8kxh 35 6 [ [ -LRB- cord-318358-glbr8kxh 35 7 9 9 CD cord-318358-glbr8kxh 35 8 ] ] -RRB- cord-318358-glbr8kxh 35 9 1 1 CD cord-318358-glbr8kxh 35 10 - - SYM cord-318358-glbr8kxh 35 11 7 7 CD cord-318358-glbr8kxh 35 12 ) ) -RRB- cord-318358-glbr8kxh 35 13 ) ) -RRB- cord-318358-glbr8kxh 35 14 . . . cord-318358-glbr8kxh 36 1 Ang Ang NNP cord-318358-glbr8kxh 36 2 II II NNP cord-318358-glbr8kxh 36 3 is be VBZ cord-318358-glbr8kxh 36 4 further further RB cord-318358-glbr8kxh 36 5 transformed transform VBN cord-318358-glbr8kxh 36 6 to to IN cord-318358-glbr8kxh 36 7 Ang Ang NNP cord-318358-glbr8kxh 36 8 III III NNP cord-318358-glbr8kxh 36 9 , , , cord-318358-glbr8kxh 36 10 Ang Ang NNP cord-318358-glbr8kxh 36 11 IV IV NNP cord-318358-glbr8kxh 36 12 and and CC cord-318358-glbr8kxh 37 1 Ang Ang NNP cord-318358-glbr8kxh 37 2 V. V. NNP cord-318358-glbr8kxh 38 1 A a DT cord-318358-glbr8kxh 38 2 negative negative JJ cord-318358-glbr8kxh 38 3 feedback feedback NN cord-318358-glbr8kxh 38 4 loop loop NN cord-318358-glbr8kxh 38 5 controls control VBZ cord-318358-glbr8kxh 38 6 Ang Ang NNP cord-318358-glbr8kxh 38 7 II II NNP cord-318358-glbr8kxh 38 8 concentration concentration NN cord-318358-glbr8kxh 38 9 changes change NNS cord-318358-glbr8kxh 38 10 with with IN cord-318358-glbr8kxh 38 11 renin renin NN cord-318358-glbr8kxh 38 12 secretion secretion NN cord-318358-glbr8kxh 38 13 that that WDT cord-318358-glbr8kxh 38 14 responds respond VBZ cord-318358-glbr8kxh 38 15 in in IN cord-318358-glbr8kxh 38 16 the the DT cord-318358-glbr8kxh 38 17 opposite opposite JJ cord-318358-glbr8kxh 38 18 direction direction NN cord-318358-glbr8kxh 38 19 . . . cord-318358-glbr8kxh 39 1 Ang Ang NNP cord-318358-glbr8kxh 39 2 II II NNP cord-318358-glbr8kxh 39 3 stimulates stimulate VBZ cord-318358-glbr8kxh 39 4 the the DT cord-318358-glbr8kxh 39 5 release release NN cord-318358-glbr8kxh 39 6 of of IN cord-318358-glbr8kxh 39 7 aldosterone aldosterone NN cord-318358-glbr8kxh 39 8 . . . cord-318358-glbr8kxh 40 1 However however RB cord-318358-glbr8kxh 40 2 , , , cord-318358-glbr8kxh 40 3 excessive excessive JJ cord-318358-glbr8kxh 40 4 Ang Ang NNP cord-318358-glbr8kxh 40 5 II II NNP cord-318358-glbr8kxh 40 6 is be VBZ cord-318358-glbr8kxh 40 7 deleterious deleterious JJ cord-318358-glbr8kxh 40 8 and and CC cord-318358-glbr8kxh 40 9 is be VBZ cord-318358-glbr8kxh 40 10 associated associate VBN cord-318358-glbr8kxh 40 11 with with IN cord-318358-glbr8kxh 40 12 hypertension hypertension NN cord-318358-glbr8kxh 40 13 , , , cord-318358-glbr8kxh 40 14 congestive congestive JJ cord-318358-glbr8kxh 40 15 heart heart NN cord-318358-glbr8kxh 40 16 failure failure NN cord-318358-glbr8kxh 40 17 and and CC cord-318358-glbr8kxh 40 18 chronic chronic JJ cord-318358-glbr8kxh 40 19 kidney kidney NN cord-318358-glbr8kxh 40 20 disease disease NN cord-318358-glbr8kxh 40 21 . . . cord-318358-glbr8kxh 41 1 ACE ace NN cord-318358-glbr8kxh 41 2 2 2 CD cord-318358-glbr8kxh 41 3 transforms transform VBZ cord-318358-glbr8kxh 41 4 Ang Ang NNP cord-318358-glbr8kxh 41 5 I I NNP cord-318358-glbr8kxh 41 6 and and CC cord-318358-glbr8kxh 41 7 Ang Ang NNP cord-318358-glbr8kxh 41 8 II II NNP cord-318358-glbr8kxh 41 9 , , , cord-318358-glbr8kxh 42 1 that that DT cord-318358-glbr8kxh 42 2 is is RB cord-318358-glbr8kxh 42 3 , , , cord-318358-glbr8kxh 42 4 Ang Ang NNP cord-318358-glbr8kxh 42 5 I i NN cord-318358-glbr8kxh 42 6 to to IN cord-318358-glbr8kxh 42 7 Ang Ang NNP cord-318358-glbr8kxh 42 8 ( ( -LRB- cord-318358-glbr8kxh 42 9 1 1 CD cord-318358-glbr8kxh 42 10 - - SYM cord-318358-glbr8kxh 42 11 9 9 CD cord-318358-glbr8kxh 42 12 ) ) -RRB- cord-318358-glbr8kxh 42 13 , , , cord-318358-glbr8kxh 42 14 and and CC cord-318358-glbr8kxh 42 15 Ang Ang NNP cord-318358-glbr8kxh 42 16 II II NNP cord-318358-glbr8kxh 42 17 to to IN cord-318358-glbr8kxh 42 18 Ang Ang NNP cord-318358-glbr8kxh 42 19 ( ( -LRB- cord-318358-glbr8kxh 42 20 1 1 CD cord-318358-glbr8kxh 42 21 - - SYM cord-318358-glbr8kxh 42 22 7 7 CD cord-318358-glbr8kxh 42 23 ) ) -RRB- cord-318358-glbr8kxh 42 24 . . . cord-318358-glbr8kxh 43 1 Ang Ang NNP cord-318358-glbr8kxh 43 2 ( ( -LRB- cord-318358-glbr8kxh 43 3 1 1 CD cord-318358-glbr8kxh 43 4 ) ) -RRB- cord-318358-glbr8kxh 43 5 ( ( -LRB- cord-318358-glbr8kxh 43 6 2 2 LS cord-318358-glbr8kxh 43 7 ) ) -RRB- cord-318358-glbr8kxh 43 8 ( ( -LRB- cord-318358-glbr8kxh 43 9 3 3 LS cord-318358-glbr8kxh 43 10 ) ) -RRB- cord-318358-glbr8kxh 43 11 ( ( -LRB- cord-318358-glbr8kxh 43 12 4 4 LS cord-318358-glbr8kxh 43 13 ) ) -RRB- cord-318358-glbr8kxh 43 14 ( ( -LRB- cord-318358-glbr8kxh 43 15 5 5 LS cord-318358-glbr8kxh 43 16 ) ) -RRB- cord-318358-glbr8kxh 43 17 ( ( -LRB- cord-318358-glbr8kxh 43 18 6 6 LS cord-318358-glbr8kxh 43 19 ) ) -RRB- cord-318358-glbr8kxh 43 20 ( ( -LRB- cord-318358-glbr8kxh 43 21 7 7 LS cord-318358-glbr8kxh 43 22 ) ) -RRB- cord-318358-glbr8kxh 43 23 ( ( -LRB- cord-318358-glbr8kxh 43 24 8) 8) NNP cord-318358-glbr8kxh 43 25 ( ( -LRB- cord-318358-glbr8kxh 43 26 9 9 CD cord-318358-glbr8kxh 43 27 ) ) -RRB- cord-318358-glbr8kxh 43 28 and and CC cord-318358-glbr8kxh 43 29 Ang Ang NNP cord-318358-glbr8kxh 43 30 ( ( -LRB- cord-318358-glbr8kxh 43 31 1 1 CD cord-318358-glbr8kxh 43 32 - - SYM cord-318358-glbr8kxh 43 33 7 7 CD cord-318358-glbr8kxh 43 34 ) ) -RRB- cord-318358-glbr8kxh 43 35 have have VBP cord-318358-glbr8kxh 43 36 protective protective JJ cord-318358-glbr8kxh 43 37 effects effect NNS cord-318358-glbr8kxh 43 38 balancing balance VBG cord-318358-glbr8kxh 43 39 the the DT cord-318358-glbr8kxh 43 40 deleterious deleterious JJ cord-318358-glbr8kxh 43 41 Ang Ang NNP cord-318358-glbr8kxh 43 42 II II NNP cord-318358-glbr8kxh 43 43 , , , cord-318358-glbr8kxh 43 44 when when WRB cord-318358-glbr8kxh 43 45 in in IN cord-318358-glbr8kxh 43 46 excess excess NN cord-318358-glbr8kxh 43 47 . . . cord-318358-glbr8kxh 44 1 A a DT cord-318358-glbr8kxh 44 2 c c NN cord-318358-glbr8kxh 44 3 c c NN cord-318358-glbr8kxh 44 4 e e NN cord-318358-glbr8kxh 44 5 p p NN cord-318358-glbr8kxh 44 6 t t NN cord-318358-glbr8kxh 44 7 e e NN cord-318358-glbr8kxh 44 8 d d NN cord-318358-glbr8kxh 44 9 M M NNP cord-318358-glbr8kxh 45 1 a a DT cord-318358-glbr8kxh 45 2 n n NN cord-318358-glbr8kxh 45 3 u u NNP cord-318358-glbr8kxh 45 4 s s NNP cord-318358-glbr8kxh 45 5 c c NN cord-318358-glbr8kxh 45 6 r r NN cord-318358-glbr8kxh 45 7 i i NN cord-318358-glbr8kxh 45 8 p p NN cord-318358-glbr8kxh 45 9 t t NN cord-318358-glbr8kxh 45 10 Figure figure NN cord-318358-glbr8kxh 45 11 1 1 CD cord-318358-glbr8kxh 45 12 _SP cord-318358-glbr8kxh 45 13 Is be VBZ cord-318358-glbr8kxh 45 14 There there EX cord-318358-glbr8kxh 45 15 an an DT cord-318358-glbr8kxh 45 16 Association Association NNP cord-318358-glbr8kxh 45 17 Between between IN cord-318358-glbr8kxh 45 18 COVID-19 COVID-19 NNP cord-318358-glbr8kxh 45 19 Mortality Mortality NNP cord-318358-glbr8kxh 45 20 and and CC cord-318358-glbr8kxh 45 21 the the DT cord-318358-glbr8kxh 45 22 Renin Renin NNP cord-318358-glbr8kxh 45 23 - - HYPH cord-318358-glbr8kxh 45 24 Angiotensin Angiotensin NNP cord-318358-glbr8kxh 45 25 System System NNP cord-318358-glbr8kxh 45 26 - - , cord-318358-glbr8kxh 45 27 a a DT cord-318358-glbr8kxh 45 28 Call call NN cord-318358-glbr8kxh 45 29 for for IN cord-318358-glbr8kxh 45 30 Epidemiologic Epidemiologic NNP cord-318358-glbr8kxh 45 31 Investigations Investigations NNPS cord-318358-glbr8kxh 45 32 Mineralocorticoid Mineralocorticoid NNP cord-318358-glbr8kxh 45 33 receptor receptor NN cord-318358-glbr8kxh 45 34 blocker blocker NN cord-318358-glbr8kxh 46 1 increases increase VBZ cord-318358-glbr8kxh 46 2 angiotensin angiotensin NN cord-318358-glbr8kxh 46 3 - - HYPH cord-318358-glbr8kxh 46 4 converting convert VBG cord-318358-glbr8kxh 46 5 enzyme enzyme NN cord-318358-glbr8kxh 46 6 2 2 CD cord-318358-glbr8kxh 46 7 activity activity NN cord-318358-glbr8kxh 46 8 in in IN cord-318358-glbr8kxh 46 9 congestive congestive JJ cord-318358-glbr8kxh 46 10 heart heart NN cord-318358-glbr8kxh 46 11 failure failure NN cord-318358-glbr8kxh 46 12 patients patient VBZ cord-318358-glbr8kxh 46 13 Individual individual JJ cord-318358-glbr8kxh 46 14 Variation Variation NNP cord-318358-glbr8kxh 46 15 of of IN cord-318358-glbr8kxh 46 16 the the DT cord-318358-glbr8kxh 46 17 SARS SARS NNP cord-318358-glbr8kxh 46 18 - - HYPH cord-318358-glbr8kxh 46 19 CoV2 CoV2 NNP cord-318358-glbr8kxh 46 20 Receptor Receptor NNP cord-318358-glbr8kxh 46 21 ACE2 ACE2 NNP cord-318358-glbr8kxh 46 22 Gene Gene NNP cord-318358-glbr8kxh 46 23 Expression Expression NNP cord-318358-glbr8kxh 46 24 and and CC cord-318358-glbr8kxh 46 25 Regulation Regulation NNP cord-318358-glbr8kxh 46 26 Tissue tissue NN cord-318358-glbr8kxh 46 27 distribution distribution NN cord-318358-glbr8kxh 46 28 of of IN cord-318358-glbr8kxh 46 29 ACE2 ACE2 NNP cord-318358-glbr8kxh 46 30 protein protein NN cord-318358-glbr8kxh 46 31 , , , cord-318358-glbr8kxh 46 32 the the DT cord-318358-glbr8kxh 46 33 functional functional JJ cord-318358-glbr8kxh 46 34 receptor receptor NN cord-318358-glbr8kxh 46 35 for for IN cord-318358-glbr8kxh 46 36 SARS SARS NNP cord-318358-glbr8kxh 46 37 coronavirus coronavirus NN cord-318358-glbr8kxh 46 38 . . . cord-318358-glbr8kxh 47 1 A a DT cord-318358-glbr8kxh 47 2 first first JJ cord-318358-glbr8kxh 47 3 step step NN cord-318358-glbr8kxh 47 4 in in IN cord-318358-glbr8kxh 47 5 understanding understand VBG cord-318358-glbr8kxh 47 6 SARS SARS NNP cord-318358-glbr8kxh 47 7 pathogenesis pathogenesis NN cord-318358-glbr8kxh 47 8 Association Association NNP cord-318358-glbr8kxh 47 9 of of IN cord-318358-glbr8kxh 47 10 Coronavirus Coronavirus NNP cord-318358-glbr8kxh 47 11 Disease Disease NNP cord-318358-glbr8kxh 47 12 2019 2019 CD cord-318358-glbr8kxh 47 13 ( ( -LRB- cord-318358-glbr8kxh 47 14 COVID-19 covid-19 VB cord-318358-glbr8kxh 47 15 ) ) -RRB- cord-318358-glbr8kxh 47 16 With with IN cord-318358-glbr8kxh 47 17 Myocardial Myocardial NNP cord-318358-glbr8kxh 47 18 Injury Injury NNP cord-318358-glbr8kxh 47 19 and and CC cord-318358-glbr8kxh 47 20 Mortality Mortality NNP cord-318358-glbr8kxh 47 21 Neurologic neurologic JJ cord-318358-glbr8kxh 47 22 Manifestations manifestation NNS cord-318358-glbr8kxh 47 23 of of IN cord-318358-glbr8kxh 47 24 Hospitalized Hospitalized NNP cord-318358-glbr8kxh 47 25 Patients Patients NNP cord-318358-glbr8kxh 47 26 With with IN cord-318358-glbr8kxh 47 27 Coronavirus Coronavirus NNP cord-318358-glbr8kxh 47 28 Disease Disease NNP cord-318358-glbr8kxh 47 29 Prevalence Prevalence NNP cord-318358-glbr8kxh 47 30 and and CC cord-318358-glbr8kxh 47 31 Clinical clinical JJ cord-318358-glbr8kxh 47 32 Characteristics characteristic NNS cord-318358-glbr8kxh 47 33 of of IN cord-318358-glbr8kxh 47 34 Mild mild JJ cord-318358-glbr8kxh 47 35 Severity severity NN cord-318358-glbr8kxh 47 36 Patients patient NNS cord-318358-glbr8kxh 47 37 with with IN cord-318358-glbr8kxh 47 38 Digestive digestive JJ cord-318358-glbr8kxh 47 39 Symptoms symptom NNS cord-318358-glbr8kxh 48 1 The the DT cord-318358-glbr8kxh 48 2 ( ( -LRB- cord-318358-glbr8kxh 48 3 pro)renin pro)renin JJ cord-318358-glbr8kxh 48 4 receptor receptor NN cord-318358-glbr8kxh 48 5 : : : cord-318358-glbr8kxh 48 6 an an DT cord-318358-glbr8kxh 48 7 emerging emerge VBG cord-318358-glbr8kxh 48 8 player player NN cord-318358-glbr8kxh 48 9 in in IN cord-318358-glbr8kxh 48 10 hypertension hypertension NN cord-318358-glbr8kxh 48 11 and and CC cord-318358-glbr8kxh 48 12 metabolic metabolic JJ cord-318358-glbr8kxh 48 13 syndrome syndrome NN cord-318358-glbr8kxh 48 14 Specific specific JJ cord-318358-glbr8kxh 48 15 and and CC cord-318358-glbr8kxh 48 16 non non JJ cord-318358-glbr8kxh 48 17 - - JJ cord-318358-glbr8kxh 48 18 specific specific JJ cord-318358-glbr8kxh 48 19 measurements measurement NNS cord-318358-glbr8kxh 48 20 of of IN cord-318358-glbr8kxh 48 21 tissue tissue NN cord-318358-glbr8kxh 48 22 angiotensin angiotensin NN cord-318358-glbr8kxh 48 23 II ii CD cord-318358-glbr8kxh 48 24 cascade cascade NN cord-318358-glbr8kxh 48 25 members member NNS