id sid tid token lemma pos cord-304487-ycvu5l5f 1 1 key key NN cord-304487-ycvu5l5f 1 2 : : : cord-304487-ycvu5l5f 2 1 cord-304487-ycvu5l5f cord-304487-ycvu5l5f NNP cord-304487-ycvu5l5f 2 2 authors author NNS cord-304487-ycvu5l5f 2 3 : : : cord-304487-ycvu5l5f 2 4 Wertheim Wertheim NNP cord-304487-ycvu5l5f 2 5 , , , cord-304487-ycvu5l5f 2 6 Joel Joel NNP cord-304487-ycvu5l5f 2 7 O O NNP cord-304487-ycvu5l5f 3 1 title title NN cord-304487-ycvu5l5f 3 2 : : : cord-304487-ycvu5l5f 4 1 A a DT cord-304487-ycvu5l5f 4 2 glimpse glimpse NN cord-304487-ycvu5l5f 4 3 into into IN cord-304487-ycvu5l5f 4 4 the the DT cord-304487-ycvu5l5f 4 5 origins origin NNS cord-304487-ycvu5l5f 4 6 of of IN cord-304487-ycvu5l5f 4 7 genetic genetic JJ cord-304487-ycvu5l5f 4 8 diversity diversity NN cord-304487-ycvu5l5f 4 9 in in IN cord-304487-ycvu5l5f 4 10 SARS SARS NNP cord-304487-ycvu5l5f 4 11 - - HYPH cord-304487-ycvu5l5f 4 12 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 4 13 date date NN cord-304487-ycvu5l5f 4 14 : : : cord-304487-ycvu5l5f 4 15 2020 2020 CD cord-304487-ycvu5l5f 4 16 - - HYPH cord-304487-ycvu5l5f 4 17 03 03 CD cord-304487-ycvu5l5f 4 18 - - HYPH cord-304487-ycvu5l5f 4 19 04 04 CD cord-304487-ycvu5l5f 4 20 journal journal NN cord-304487-ycvu5l5f 4 21 : : : cord-304487-ycvu5l5f 5 1 Clin Clin NNP cord-304487-ycvu5l5f 5 2 Infect infect VB cord-304487-ycvu5l5f 5 3 Dis Dis NNP cord-304487-ycvu5l5f 5 4 DOI doi NN cord-304487-ycvu5l5f 5 5 : : : cord-304487-ycvu5l5f 6 1 10.1093 10.1093 CD cord-304487-ycvu5l5f 6 2 / / SYM cord-304487-ycvu5l5f 6 3 cid cid NN cord-304487-ycvu5l5f 6 4 / / SYM cord-304487-ycvu5l5f 6 5 ciaa213 ciaa213 NNP cord-304487-ycvu5l5f 6 6 sha sha NNP cord-304487-ycvu5l5f 6 7 : : : cord-304487-ycvu5l5f 7 1 7a288871cdefc846dc86b9d565062ebaf0c2bb9c 7a288871cdefc846dc86b9d565062ebaf0c2bb9c NNP cord-304487-ycvu5l5f 7 2 doc_id doc_id NNP cord-304487-ycvu5l5f 7 3 : : : cord-304487-ycvu5l5f 7 4 304487 304487 CD cord-304487-ycvu5l5f 7 5 cord_uid cord_uid NNS cord-304487-ycvu5l5f 7 6 : : : cord-304487-ycvu5l5f 8 1 ycvu5l5f ycvu5l5f NNP cord-304487-ycvu5l5f 8 2 nan nan NNP cord-304487-ycvu5l5f 9 1 A a DT cord-304487-ycvu5l5f 9 2 deadly deadly JJ cord-304487-ycvu5l5f 9 3 pathogen pathogen NN cord-304487-ycvu5l5f 9 4 has have VBZ cord-304487-ycvu5l5f 9 5 found find VBN cord-304487-ycvu5l5f 9 6 a a DT cord-304487-ycvu5l5f 9 7 new new JJ cord-304487-ycvu5l5f 9 8 host host NN cord-304487-ycvu5l5f 9 9 . . . cord-304487-ycvu5l5f 10 1 Near near IN cord-304487-ycvu5l5f 10 2 the the DT cord-304487-ycvu5l5f 10 3 end end NN cord-304487-ycvu5l5f 10 4 of of IN cord-304487-ycvu5l5f 10 5 2019 2019 CD cord-304487-ycvu5l5f 10 6 , , , cord-304487-ycvu5l5f 10 7 the the DT cord-304487-ycvu5l5f 10 8 novel novel JJ cord-304487-ycvu5l5f 10 9 coronavirus coronavirus NN cord-304487-ycvu5l5f 10 10 SARS SARS NNP cord-304487-ycvu5l5f 10 11 - - HYPH cord-304487-ycvu5l5f 10 12 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 10 13 began begin VBD cord-304487-ycvu5l5f 10 14 transmitting transmit VBG cord-304487-ycvu5l5f 10 15 among among IN cord-304487-ycvu5l5f 10 16 humans human NNS cord-304487-ycvu5l5f 10 17 . . . cord-304487-ycvu5l5f 11 1 In in IN cord-304487-ycvu5l5f 11 2 the the DT cord-304487-ycvu5l5f 11 3 first first JJ cord-304487-ycvu5l5f 11 4 two two CD cord-304487-ycvu5l5f 11 5 months month NNS cord-304487-ycvu5l5f 11 6 following follow VBG cord-304487-ycvu5l5f 11 7 its -PRON- PRP$ cord-304487-ycvu5l5f 11 8 discovery discovery NN cord-304487-ycvu5l5f 11 9 , , , cord-304487-ycvu5l5f 11 10 over over IN cord-304487-ycvu5l5f 11 11 75,000 75,000 CD cord-304487-ycvu5l5f 11 12 cases case NNS cord-304487-ycvu5l5f 11 13 of of IN cord-304487-ycvu5l5f 11 14 COVID-19 covid-19 JJ cord-304487-ycvu5l5f 11 15 causing cause VBG cord-304487-ycvu5l5f 11 16 over over IN cord-304487-ycvu5l5f 11 17 2,000 2,000 CD cord-304487-ycvu5l5f 11 18 deaths death NNS cord-304487-ycvu5l5f 11 19 have have VBP cord-304487-ycvu5l5f 11 20 been be VBN cord-304487-ycvu5l5f 11 21 confirmed confirm VBN cord-304487-ycvu5l5f 11 22 . . . cord-304487-ycvu5l5f 12 1 Researchers researcher NNS cord-304487-ycvu5l5f 12 2 rapidly rapidly RB cord-304487-ycvu5l5f 12 3 characterized characterize VBD cord-304487-ycvu5l5f 12 4 the the DT cord-304487-ycvu5l5f 12 5 viral viral JJ cord-304487-ycvu5l5f 12 6 genome genome NN cord-304487-ycvu5l5f 12 7 [ [ -LRB- cord-304487-ycvu5l5f 12 8 1 1 CD cord-304487-ycvu5l5f 12 9 ] ] -RRB- cord-304487-ycvu5l5f 12 10 and and CC cord-304487-ycvu5l5f 12 11 have have VBP cord-304487-ycvu5l5f 12 12 already already RB cord-304487-ycvu5l5f 12 13 identified identify VBN cord-304487-ycvu5l5f 12 14 a a DT cord-304487-ycvu5l5f 12 15 closely closely RB cord-304487-ycvu5l5f 12 16 related related JJ cord-304487-ycvu5l5f 12 17 virus virus NN cord-304487-ycvu5l5f 12 18 in in IN cord-304487-ycvu5l5f 12 19 bats bat NNS cord-304487-ycvu5l5f 12 20 [ [ -LRB- cord-304487-ycvu5l5f 12 21 2 2 CD cord-304487-ycvu5l5f 12 22 ] ] -RRB- cord-304487-ycvu5l5f 12 23 , , , cord-304487-ycvu5l5f 12 24 pointing point VBG cord-304487-ycvu5l5f 12 25 to to IN cord-304487-ycvu5l5f 12 26 these these DT cord-304487-ycvu5l5f 12 27 animals animal NNS cord-304487-ycvu5l5f 12 28 as as IN cord-304487-ycvu5l5f 12 29 the the DT cord-304487-ycvu5l5f 12 30 likely likely JJ cord-304487-ycvu5l5f 12 31 natural natural JJ cord-304487-ycvu5l5f 12 32 reservoir reservoir NN cord-304487-ycvu5l5f 12 33 of of IN cord-304487-ycvu5l5f 12 34 this this DT cord-304487-ycvu5l5f 12 35 virus virus NN cord-304487-ycvu5l5f 12 36 . . . cord-304487-ycvu5l5f 13 1 The the DT cord-304487-ycvu5l5f 13 2 search search NN cord-304487-ycvu5l5f 13 3 continues continue VBZ cord-304487-ycvu5l5f 13 4 for for IN cord-304487-ycvu5l5f 13 5 an an DT cord-304487-ycvu5l5f 13 6 intermediate intermediate JJ cord-304487-ycvu5l5f 13 7 host host NN cord-304487-ycvu5l5f 13 8 animal animal NN cord-304487-ycvu5l5f 13 9 that that WDT cord-304487-ycvu5l5f 13 10 may may MD cord-304487-ycvu5l5f 13 11 have have VB cord-304487-ycvu5l5f 13 12 facilitated facilitate VBN cord-304487-ycvu5l5f 13 13 the the DT cord-304487-ycvu5l5f 13 14 zoonosis zoonosis NN cord-304487-ycvu5l5f 13 15 , , , cord-304487-ycvu5l5f 13 16 like like IN cord-304487-ycvu5l5f 13 17 camels camel NNS cord-304487-ycvu5l5f 13 18 do do VBP cord-304487-ycvu5l5f 13 19 for for IN cord-304487-ycvu5l5f 13 20 MERS MERS NNP cord-304487-ycvu5l5f 13 21 - - HYPH cord-304487-ycvu5l5f 13 22 CoV CoV NNP cord-304487-ycvu5l5f 13 23 and and CC cord-304487-ycvu5l5f 13 24 palm palm NN cord-304487-ycvu5l5f 13 25 civets civet NNS cord-304487-ycvu5l5f 13 26 did do VBD cord-304487-ycvu5l5f 13 27 for for IN cord-304487-ycvu5l5f 13 28 SARS SARS NNP cord-304487-ycvu5l5f 13 29 - - HYPH cord-304487-ycvu5l5f 13 30 CoV. CoV. NNP cord-304487-ycvu5l5f 14 1 From from IN cord-304487-ycvu5l5f 14 2 a a DT cord-304487-ycvu5l5f 14 3 clinical clinical JJ cord-304487-ycvu5l5f 14 4 and and CC cord-304487-ycvu5l5f 14 5 epidemiological epidemiological JJ cord-304487-ycvu5l5f 14 6 perspective perspective NN cord-304487-ycvu5l5f 14 7 , , , cord-304487-ycvu5l5f 14 8 there there EX cord-304487-ycvu5l5f 14 9 is be VBZ cord-304487-ycvu5l5f 14 10 obvious obvious JJ cord-304487-ycvu5l5f 14 11 interest interest NN cord-304487-ycvu5l5f 14 12 in in IN cord-304487-ycvu5l5f 14 13 whether whether IN cord-304487-ycvu5l5f 14 14 SARS SARS NNP cord-304487-ycvu5l5f 14 15 - - HYPH cord-304487-ycvu5l5f 14 16 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 14 17 will will MD cord-304487-ycvu5l5f 14 18 adapt adapt VB cord-304487-ycvu5l5f 14 19 to to TO cord-304487-ycvu5l5f 14 20 become become VB cord-304487-ycvu5l5f 14 21 more more RBR cord-304487-ycvu5l5f 14 22 transmissible transmissible JJ cord-304487-ycvu5l5f 14 23 and/or and/or CC cord-304487-ycvu5l5f 14 24 virulent virulent JJ cord-304487-ycvu5l5f 14 25 in in IN cord-304487-ycvu5l5f 14 26 humans human NNS cord-304487-ycvu5l5f 14 27 . . . cord-304487-ycvu5l5f 15 1 Before before IN cord-304487-ycvu5l5f 15 2 we -PRON- PRP cord-304487-ycvu5l5f 15 3 can can MD cord-304487-ycvu5l5f 15 4 address address VB cord-304487-ycvu5l5f 15 5 this this DT cord-304487-ycvu5l5f 15 6 question question NN cord-304487-ycvu5l5f 15 7 , , , cord-304487-ycvu5l5f 15 8 it -PRON- PRP cord-304487-ycvu5l5f 15 9 is be VBZ cord-304487-ycvu5l5f 15 10 importantly importantly RB cord-304487-ycvu5l5f 15 11 to to TO cord-304487-ycvu5l5f 15 12 realize realize VB cord-304487-ycvu5l5f 15 13 that that IN cord-304487-ycvu5l5f 15 14 most most JJS cord-304487-ycvu5l5f 15 15 evolutionary evolutionary JJ cord-304487-ycvu5l5f 15 16 options option NNS cord-304487-ycvu5l5f 15 17 available available JJ cord-304487-ycvu5l5f 15 18 to to IN cord-304487-ycvu5l5f 15 19 this this DT cord-304487-ycvu5l5f 15 20 virus virus NN cord-304487-ycvu5l5f 15 21 have have VBP cord-304487-ycvu5l5f 15 22 already already RB cord-304487-ycvu5l5f 15 23 been be VBN cord-304487-ycvu5l5f 15 24 explored explore VBN cord-304487-ycvu5l5f 15 25 in in IN cord-304487-ycvu5l5f 15 26 bats bat NNS cord-304487-ycvu5l5f 15 27 , , , cord-304487-ycvu5l5f 15 28 where where WRB cord-304487-ycvu5l5f 15 29 there there EX cord-304487-ycvu5l5f 15 30 is be VBZ cord-304487-ycvu5l5f 15 31 an an DT cord-304487-ycvu5l5f 15 32 immense immense JJ cord-304487-ycvu5l5f 15 33 array array NN cord-304487-ycvu5l5f 15 34 of of IN cord-304487-ycvu5l5f 15 35 genetically genetically RB cord-304487-ycvu5l5f 15 36 distinct distinct JJ cord-304487-ycvu5l5f 15 37 coronaviruses coronaviruse NNS cord-304487-ycvu5l5f 15 38 . . . cord-304487-ycvu5l5f 16 1 Viruses virus NNS cord-304487-ycvu5l5f 16 2 in in IN cord-304487-ycvu5l5f 16 3 the the DT cord-304487-ycvu5l5f 16 4 betacoronavirus betacoronavirus NN cord-304487-ycvu5l5f 16 5 genus genus NN cord-304487-ycvu5l5f 16 6 , , , cord-304487-ycvu5l5f 16 7 to to TO cord-304487-ycvu5l5f 16 8 which which WDT cord-304487-ycvu5l5f 16 9 SARS SARS NNP cord-304487-ycvu5l5f 16 10 - - HYPH cord-304487-ycvu5l5f 16 11 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 16 12 belongs belong VBZ cord-304487-ycvu5l5f 16 13 , , , cord-304487-ycvu5l5f 16 14 have have VBP cord-304487-ycvu5l5f 16 15 likely likely RB cord-304487-ycvu5l5f 16 16 been be VBN cord-304487-ycvu5l5f 16 17 infecting infect VBG cord-304487-ycvu5l5f 16 18 bats bat NNS cord-304487-ycvu5l5f 16 19 for for IN cord-304487-ycvu5l5f 16 20 tens ten NNS cord-304487-ycvu5l5f 16 21 of of IN cord-304487-ycvu5l5f 16 22 millions million NNS cord-304487-ycvu5l5f 16 23 of of IN cord-304487-ycvu5l5f 16 24 years year NNS cord-304487-ycvu5l5f 16 25 , , , cord-304487-ycvu5l5f 16 26 possibly possibly RB cord-304487-ycvu5l5f 16 27 since since IN cord-304487-ycvu5l5f 16 28 the the DT cord-304487-ycvu5l5f 16 29 origin origin NN cord-304487-ycvu5l5f 16 30 of of IN cord-304487-ycvu5l5f 16 31 bats bat NNS cord-304487-ycvu5l5f 16 32 themselves -PRON- PRP cord-304487-ycvu5l5f 16 33 [ [ -LRB- cord-304487-ycvu5l5f 16 34 3 3 CD cord-304487-ycvu5l5f 16 35 ] ] -RRB- cord-304487-ycvu5l5f 16 36 . . . cord-304487-ycvu5l5f 17 1 Within within IN cord-304487-ycvu5l5f 17 2 this this DT cord-304487-ycvu5l5f 17 3 natural natural JJ cord-304487-ycvu5l5f 17 4 reservoir reservoir NN cord-304487-ycvu5l5f 17 5 , , , cord-304487-ycvu5l5f 17 6 viruses virus NNS cord-304487-ycvu5l5f 17 7 exist exist VBP cord-304487-ycvu5l5f 17 8 that that WDT cord-304487-ycvu5l5f 17 9 would would MD cord-304487-ycvu5l5f 17 10 cause cause VB cord-304487-ycvu5l5f 17 11 high high JJ cord-304487-ycvu5l5f 17 12 and and CC cord-304487-ycvu5l5f 17 13 low low JJ cord-304487-ycvu5l5f 17 14 virulence virulence NN cord-304487-ycvu5l5f 17 15 in in IN cord-304487-ycvu5l5f 17 16 humans human NNS cord-304487-ycvu5l5f 17 17 , , , cord-304487-ycvu5l5f 17 18 as as RB cord-304487-ycvu5l5f 17 19 well well RB cord-304487-ycvu5l5f 17 20 as as IN cord-304487-ycvu5l5f 17 21 those those DT cord-304487-ycvu5l5f 17 22 viruses virus NNS cord-304487-ycvu5l5f 17 23 that that WDT cord-304487-ycvu5l5f 17 24 are be VBP cord-304487-ycvu5l5f 17 25 easily easily RB cord-304487-ycvu5l5f 17 26 transmissible transmissible JJ cord-304487-ycvu5l5f 17 27 from from IN cord-304487-ycvu5l5f 17 28 human human JJ cord-304487-ycvu5l5f 17 29 to to IN cord-304487-ycvu5l5f 17 30 human human NN cord-304487-ycvu5l5f 17 31 . . . cord-304487-ycvu5l5f 18 1 Evolution evolution NN cord-304487-ycvu5l5f 18 2 tinkers tinker NNS cord-304487-ycvu5l5f 18 3 with with IN cord-304487-ycvu5l5f 18 4 these these DT cord-304487-ycvu5l5f 18 5 viruses virus NNS cord-304487-ycvu5l5f 18 6 in in IN cord-304487-ycvu5l5f 18 7 bats bat NNS cord-304487-ycvu5l5f 18 8 , , , cord-304487-ycvu5l5f 18 9 and and CC cord-304487-ycvu5l5f 18 10 the the DT cord-304487-ycvu5l5f 18 11 epidemiological epidemiological JJ cord-304487-ycvu5l5f 18 12 consequences consequence NNS cord-304487-ycvu5l5f 18 13 are be VBP cord-304487-ycvu5l5f 18 14 seen see VBN cord-304487-ycvu5l5f 18 15 both both CC cord-304487-ycvu5l5f 18 16 in in IN cord-304487-ycvu5l5f 18 17 pathogenic pathogenic JJ cord-304487-ycvu5l5f 18 18 zoonotic zoonotic JJ cord-304487-ycvu5l5f 18 19 diseases disease NNS cord-304487-ycvu5l5f 18 20 ( ( -LRB- cord-304487-ycvu5l5f 18 21 e.g. e.g. RB cord-304487-ycvu5l5f 18 22 , , , cord-304487-ycvu5l5f 18 23 SARS SARS NNP cord-304487-ycvu5l5f 18 24 , , , cord-304487-ycvu5l5f 18 25 MERS MERS NNP cord-304487-ycvu5l5f 18 26 , , , cord-304487-ycvu5l5f 18 27 and and CC cord-304487-ycvu5l5f 18 28 COVID-19 COVID-19 NNP cord-304487-ycvu5l5f 18 29 ) ) -RRB- cord-304487-ycvu5l5f 18 30 and and CC cord-304487-ycvu5l5f 18 31 in in IN cord-304487-ycvu5l5f 18 32 the the DT cord-304487-ycvu5l5f 18 33 less less RBR cord-304487-ycvu5l5f 18 34 - - HYPH cord-304487-ycvu5l5f 18 35 virulent virulent JJ cord-304487-ycvu5l5f 18 36 circulating circulate VBG cord-304487-ycvu5l5f 18 37 coronaviruses coronaviruse NNS cord-304487-ycvu5l5f 18 38 causing cause VBG cord-304487-ycvu5l5f 18 39 common common JJ cord-304487-ycvu5l5f 18 40 colds cold NNS cord-304487-ycvu5l5f 18 41 . . . cord-304487-ycvu5l5f 19 1 Occasionally occasionally RB cord-304487-ycvu5l5f 19 2 , , , cord-304487-ycvu5l5f 19 3 however however RB cord-304487-ycvu5l5f 19 4 , , , cord-304487-ycvu5l5f 19 5 some some DT cord-304487-ycvu5l5f 19 6 evolutionary evolutionary JJ cord-304487-ycvu5l5f 19 7 avenues avenue NNS cord-304487-ycvu5l5f 19 8 are be VBP cord-304487-ycvu5l5f 19 9 not not RB cord-304487-ycvu5l5f 19 10 available available JJ cord-304487-ycvu5l5f 19 11 to to IN cord-304487-ycvu5l5f 19 12 a a DT cord-304487-ycvu5l5f 19 13 zoonotic zoonotic JJ cord-304487-ycvu5l5f 19 14 pathogen pathogen NN cord-304487-ycvu5l5f 19 15 until until IN cord-304487-ycvu5l5f 19 16 after after IN cord-304487-ycvu5l5f 19 17 arrival arrival NN cord-304487-ycvu5l5f 19 18 in in IN cord-304487-ycvu5l5f 19 19 humans human NNS cord-304487-ycvu5l5f 19 20 [ [ -LRB- cord-304487-ycvu5l5f 19 21 4 4 CD cord-304487-ycvu5l5f 19 22 ] ] -RRB- cord-304487-ycvu5l5f 19 23 . . . cord-304487-ycvu5l5f 20 1 Evolution evolution NN cord-304487-ycvu5l5f 20 2 requires require VBZ cord-304487-ycvu5l5f 20 3 genetic genetic JJ cord-304487-ycvu5l5f 20 4 diversity diversity NN cord-304487-ycvu5l5f 20 5 , , , cord-304487-ycvu5l5f 20 6 and and CC cord-304487-ycvu5l5f 20 7 genetic genetic JJ cord-304487-ycvu5l5f 20 8 diversity diversity NN cord-304487-ycvu5l5f 20 9 arises arise VBZ cord-304487-ycvu5l5f 20 10 from from IN cord-304487-ycvu5l5f 20 11 two two CD cord-304487-ycvu5l5f 20 12 distinct distinct JJ cord-304487-ycvu5l5f 20 13 mechanisms mechanism NNS cord-304487-ycvu5l5f 20 14 : : : cord-304487-ycvu5l5f 20 15 mutation mutation NN cord-304487-ycvu5l5f 20 16 and and CC cord-304487-ycvu5l5f 20 17 recombination recombination NN cord-304487-ycvu5l5f 20 18 . . . cord-304487-ycvu5l5f 21 1 Mutation mutation NN cord-304487-ycvu5l5f 21 2 is be VBZ cord-304487-ycvu5l5f 21 3 the the DT cord-304487-ycvu5l5f 21 4 replacement replacement NN cord-304487-ycvu5l5f 21 5 of of IN cord-304487-ycvu5l5f 21 6 one one CD cord-304487-ycvu5l5f 21 7 nucleotide nucleotide JJ cord-304487-ycvu5l5f 21 8 base base NN cord-304487-ycvu5l5f 21 9 with with IN cord-304487-ycvu5l5f 21 10 another another DT cord-304487-ycvu5l5f 21 11 , , , cord-304487-ycvu5l5f 21 12 or or CC cord-304487-ycvu5l5f 21 13 the the DT cord-304487-ycvu5l5f 21 14 addition addition NN cord-304487-ycvu5l5f 21 15 / / SYM cord-304487-ycvu5l5f 21 16 removal removal NN cord-304487-ycvu5l5f 21 17 of of IN cord-304487-ycvu5l5f 21 18 nucleotide(s nucleotide(s NNP cord-304487-ycvu5l5f 21 19 ) ) -RRB- cord-304487-ycvu5l5f 21 20 . . . cord-304487-ycvu5l5f 22 1 Mutations mutation NNS cord-304487-ycvu5l5f 22 2 are be VBP cord-304487-ycvu5l5f 22 3 the the DT cord-304487-ycvu5l5f 22 4 only only JJ cord-304487-ycvu5l5f 22 5 true true JJ cord-304487-ycvu5l5f 22 6 source source NN cord-304487-ycvu5l5f 22 7 of of IN cord-304487-ycvu5l5f 22 8 genetic genetic JJ cord-304487-ycvu5l5f 22 9 novelty novelty NN cord-304487-ycvu5l5f 22 10 . . . cord-304487-ycvu5l5f 23 1 Recombination recombination NN cord-304487-ycvu5l5f 23 2 , , , cord-304487-ycvu5l5f 23 3 on on IN cord-304487-ycvu5l5f 23 4 the the DT cord-304487-ycvu5l5f 23 5 other other JJ cord-304487-ycvu5l5f 23 6 hand hand NN cord-304487-ycvu5l5f 23 7 , , , cord-304487-ycvu5l5f 23 8 can can MD cord-304487-ycvu5l5f 23 9 increase increase VB cord-304487-ycvu5l5f 23 10 genetic genetic JJ cord-304487-ycvu5l5f 23 11 diversity diversity NN cord-304487-ycvu5l5f 23 12 by by IN cord-304487-ycvu5l5f 23 13 placing place VBG cord-304487-ycvu5l5f 23 14 existing exist VBG cord-304487-ycvu5l5f 23 15 mutations mutation NNS cord-304487-ycvu5l5f 23 16 into into IN cord-304487-ycvu5l5f 23 17 new new JJ cord-304487-ycvu5l5f 23 18 genetic genetic JJ cord-304487-ycvu5l5f 23 19 backgrounds background NNS cord-304487-ycvu5l5f 23 20 . . . cord-304487-ycvu5l5f 24 1 Two two CD cord-304487-ycvu5l5f 24 2 articles article NNS cord-304487-ycvu5l5f 24 3 in in IN cord-304487-ycvu5l5f 24 4 the the DT cord-304487-ycvu5l5f 24 5 most most RBS cord-304487-ycvu5l5f 24 6 recent recent JJ cord-304487-ycvu5l5f 24 7 issue issue NN cord-304487-ycvu5l5f 24 8 of of IN cord-304487-ycvu5l5f 24 9 Clinical Clinical NNP cord-304487-ycvu5l5f 24 10 Infectious Infectious NNP cord-304487-ycvu5l5f 24 11 Diseases Diseases NNPS cord-304487-ycvu5l5f 24 12 explore explore VBP cord-304487-ycvu5l5f 24 13 these these DT cord-304487-ycvu5l5f 24 14 sources source NNS cord-304487-ycvu5l5f 24 15 of of IN cord-304487-ycvu5l5f 24 16 genetic genetic JJ cord-304487-ycvu5l5f 24 17 variation variation NN cord-304487-ycvu5l5f 24 18 in in IN cord-304487-ycvu5l5f 24 19 SARS SARS NNP cord-304487-ycvu5l5f 24 20 - - HYPH cord-304487-ycvu5l5f 24 21 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 24 22 . . . cord-304487-ycvu5l5f 25 1 Li Li NNP cord-304487-ycvu5l5f 25 2 and and CC cord-304487-ycvu5l5f 25 3 colleagues colleague NNS cord-304487-ycvu5l5f 25 4 describe describe VBP cord-304487-ycvu5l5f 25 5 the the DT cord-304487-ycvu5l5f 25 6 genetic genetic JJ cord-304487-ycvu5l5f 25 7 variability variability NN cord-304487-ycvu5l5f 25 8 within within IN cord-304487-ycvu5l5f 25 9 7 7 CD cord-304487-ycvu5l5f 26 1 COVID-19 covid-19 JJ cord-304487-ycvu5l5f 26 2 patients patient NNS cord-304487-ycvu5l5f 26 3 from from IN cord-304487-ycvu5l5f 26 4 China China NNP cord-304487-ycvu5l5f 26 5 . . . cord-304487-ycvu5l5f 27 1 Yi Yi NNP cord-304487-ycvu5l5f 27 2 explores explore VBZ cord-304487-ycvu5l5f 27 3 potential potential JJ cord-304487-ycvu5l5f 27 4 instances instance NNS cord-304487-ycvu5l5f 27 5 of of IN cord-304487-ycvu5l5f 27 6 recombination recombination NN cord-304487-ycvu5l5f 27 7 among among IN cord-304487-ycvu5l5f 27 8 84 84 CD cord-304487-ycvu5l5f 27 9 SARS SARS NNP cord-304487-ycvu5l5f 27 10 - - HYPH cord-304487-ycvu5l5f 27 11 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 27 12 genomes genome NNS cord-304487-ycvu5l5f 27 13 from from IN cord-304487-ycvu5l5f 27 14 multiple multiple JJ cord-304487-ycvu5l5f 27 15 countries country NNS cord-304487-ycvu5l5f 27 16 . . . cord-304487-ycvu5l5f 28 1 Molecular molecular JJ cord-304487-ycvu5l5f 28 2 epidemiology epidemiology NN cord-304487-ycvu5l5f 28 3 can can MD cord-304487-ycvu5l5f 28 4 use use VB cord-304487-ycvu5l5f 28 5 the the DT cord-304487-ycvu5l5f 28 6 genetic genetic JJ cord-304487-ycvu5l5f 28 7 variation variation NN cord-304487-ycvu5l5f 28 8 of of IN cord-304487-ycvu5l5f 28 9 SARS SARS NNP cord-304487-ycvu5l5f 28 10 - - HYPH cord-304487-ycvu5l5f 28 11 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 28 12 to to TO cord-304487-ycvu5l5f 28 13 trace trace VB cord-304487-ycvu5l5f 28 14 its -PRON- PRP$ cord-304487-ycvu5l5f 28 15 history history NN cord-304487-ycvu5l5f 28 16 and and CC cord-304487-ycvu5l5f 28 17 better well RBR cord-304487-ycvu5l5f 28 18 understand understand VB cord-304487-ycvu5l5f 28 19 clusters cluster NNS cord-304487-ycvu5l5f 28 20 of of IN cord-304487-ycvu5l5f 28 21 transmission transmission NN cord-304487-ycvu5l5f 28 22 . . . cord-304487-ycvu5l5f 29 1 When when WRB cord-304487-ycvu5l5f 29 2 we -PRON- PRP cord-304487-ycvu5l5f 29 3 examine examine VBP cord-304487-ycvu5l5f 29 4 viruses virus NNS cord-304487-ycvu5l5f 29 5 infecting infect VBG cord-304487-ycvu5l5f 29 6 two two CD cord-304487-ycvu5l5f 29 7 different different JJ cord-304487-ycvu5l5f 29 8 people people NNS cord-304487-ycvu5l5f 29 9 , , , cord-304487-ycvu5l5f 29 10 the the DT cord-304487-ycvu5l5f 29 11 amount amount NN cord-304487-ycvu5l5f 29 12 of of IN cord-304487-ycvu5l5f 29 13 genetic genetic JJ cord-304487-ycvu5l5f 29 14 similarity similarity NN cord-304487-ycvu5l5f 29 15 between between IN cord-304487-ycvu5l5f 29 16 these these DT cord-304487-ycvu5l5f 29 17 viruses virus NNS cord-304487-ycvu5l5f 29 18 is be VBZ cord-304487-ycvu5l5f 29 19 a a DT cord-304487-ycvu5l5f 29 20 proxy proxy NN cord-304487-ycvu5l5f 29 21 for for IN cord-304487-ycvu5l5f 29 22 the the DT cord-304487-ycvu5l5f 29 23 directness directness NN cord-304487-ycvu5l5f 29 24 of of IN cord-304487-ycvu5l5f 29 25 their -PRON- PRP$ cord-304487-ycvu5l5f 29 26 epidemiological epidemiological JJ cord-304487-ycvu5l5f 29 27 relationship relationship NN cord-304487-ycvu5l5f 29 28 . . . cord-304487-ycvu5l5f 30 1 Direct direct JJ cord-304487-ycvu5l5f 30 2 transmission transmission NN cord-304487-ycvu5l5f 30 3 partners partner NNS cord-304487-ycvu5l5f 30 4 are be VBP cord-304487-ycvu5l5f 30 5 more more RBR cord-304487-ycvu5l5f 30 6 likely likely JJ cord-304487-ycvu5l5f 30 7 to to TO cord-304487-ycvu5l5f 30 8 have have VB cord-304487-ycvu5l5f 30 9 identical identical JJ cord-304487-ycvu5l5f 30 10 or or CC cord-304487-ycvu5l5f 30 11 nearly nearly RB cord-304487-ycvu5l5f 30 12 identical identical JJ cord-304487-ycvu5l5f 30 13 sequences sequence NNS cord-304487-ycvu5l5f 30 14 . . . cord-304487-ycvu5l5f 31 1 Bear bear VB cord-304487-ycvu5l5f 31 2 in in IN cord-304487-ycvu5l5f 31 3 mind mind NN cord-304487-ycvu5l5f 31 4 that that IN cord-304487-ycvu5l5f 31 5 the the DT cord-304487-ycvu5l5f 31 6 genetic genetic JJ cord-304487-ycvu5l5f 31 7 differences difference NNS cord-304487-ycvu5l5f 31 8 separating separate VBG cord-304487-ycvu5l5f 31 9 these these DT cord-304487-ycvu5l5f 31 10 viruses virus NNS cord-304487-ycvu5l5f 31 11 did do VBD cord-304487-ycvu5l5f 31 12 not not RB cord-304487-ycvu5l5f 31 13 arise arise VB cord-304487-ycvu5l5f 31 14 between between IN cord-304487-ycvu5l5f 31 15 these these DT cord-304487-ycvu5l5f 31 16 individuals individual NNS cord-304487-ycvu5l5f 32 1 ; ; : cord-304487-ycvu5l5f 32 2 rather rather RB cord-304487-ycvu5l5f 32 3 , , , cord-304487-ycvu5l5f 32 4 all all DT cord-304487-ycvu5l5f 32 5 mutations mutation NNS cord-304487-ycvu5l5f 32 6 arise arise VBP cord-304487-ycvu5l5f 32 7 during during IN cord-304487-ycvu5l5f 32 8 intra intra JJ cord-304487-ycvu5l5f 32 9 - - JJ cord-304487-ycvu5l5f 32 10 host host JJ cord-304487-ycvu5l5f 32 11 replication replication NN cord-304487-ycvu5l5f 32 12 . . . cord-304487-ycvu5l5f 33 1 In in IN cord-304487-ycvu5l5f 33 2 this this DT cord-304487-ycvu5l5f 33 3 issue issue NN cord-304487-ycvu5l5f 33 4 , , , cord-304487-ycvu5l5f 33 5 Li Li NNP cord-304487-ycvu5l5f 33 6 and and CC cord-304487-ycvu5l5f 33 7 colleagues colleague NNS cord-304487-ycvu5l5f 33 8 reveal reveal VBP cord-304487-ycvu5l5f 33 9 the the DT cord-304487-ycvu5l5f 33 10 intra intra JJ cord-304487-ycvu5l5f 33 11 - - JJ cord-304487-ycvu5l5f 33 12 host host JJ cord-304487-ycvu5l5f 33 13 genetic genetic JJ cord-304487-ycvu5l5f 33 14 variation variation NN cord-304487-ycvu5l5f 33 15 of of IN cord-304487-ycvu5l5f 33 16 SARS SARS NNP cord-304487-ycvu5l5f 33 17 - - HYPH cord-304487-ycvu5l5f 33 18 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 33 19 . . . cord-304487-ycvu5l5f 34 1 When when WRB cord-304487-ycvu5l5f 34 2 these these DT cord-304487-ycvu5l5f 34 3 researchers researcher NNS cord-304487-ycvu5l5f 34 4 examined examine VBD cord-304487-ycvu5l5f 34 5 genomes genome NNS cord-304487-ycvu5l5f 34 6 from from IN cord-304487-ycvu5l5f 34 7 a a DT cord-304487-ycvu5l5f 34 8 probable probable JJ cord-304487-ycvu5l5f 34 9 transmission transmission NN cord-304487-ycvu5l5f 34 10 pair pair NN cord-304487-ycvu5l5f 34 11 who who WP cord-304487-ycvu5l5f 34 12 resided reside VBD cord-304487-ycvu5l5f 34 13 in in IN cord-304487-ycvu5l5f 34 14 the the DT cord-304487-ycvu5l5f 34 15 same same JJ cord-304487-ycvu5l5f 34 16 house house NN cord-304487-ycvu5l5f 34 17 , , , cord-304487-ycvu5l5f 34 18 they -PRON- PRP cord-304487-ycvu5l5f 34 19 found find VBD cord-304487-ycvu5l5f 34 20 the the DT cord-304487-ycvu5l5f 34 21 consensus consensus NN cord-304487-ycvu5l5f 34 22 sequences sequence NNS cord-304487-ycvu5l5f 34 23 to to TO cord-304487-ycvu5l5f 34 24 be be VB cord-304487-ycvu5l5f 34 25 identical identical JJ cord-304487-ycvu5l5f 34 26 . . . cord-304487-ycvu5l5f 35 1 However however RB cord-304487-ycvu5l5f 35 2 , , , cord-304487-ycvu5l5f 35 3 deep deep JJ cord-304487-ycvu5l5f 35 4 - - HYPH cord-304487-ycvu5l5f 35 5 sequencing sequencing NN cord-304487-ycvu5l5f 35 6 of of IN cord-304487-ycvu5l5f 35 7 viral viral JJ cord-304487-ycvu5l5f 35 8 genomes genome NNS cord-304487-ycvu5l5f 35 9 from from IN cord-304487-ycvu5l5f 35 10 7 7 CD cord-304487-ycvu5l5f 35 11 patients patient NNS cord-304487-ycvu5l5f 35 12 ( ( -LRB- cord-304487-ycvu5l5f 35 13 including include VBG cord-304487-ycvu5l5f 35 14 this this DT cord-304487-ycvu5l5f 35 15 probable probable JJ cord-304487-ycvu5l5f 35 16 transmission transmission NN cord-304487-ycvu5l5f 35 17 pair pair NN cord-304487-ycvu5l5f 35 18 ) ) -RRB- cord-304487-ycvu5l5f 35 19 , , , cord-304487-ycvu5l5f 35 20 the the DT cord-304487-ycvu5l5f 35 21 authors author NNS cord-304487-ycvu5l5f 35 22 detect detect VBP cord-304487-ycvu5l5f 35 23 substantial substantial JJ cord-304487-ycvu5l5f 35 24 variation variation NN cord-304487-ycvu5l5f 35 25 in in IN cord-304487-ycvu5l5f 35 26 the the DT cord-304487-ycvu5l5f 35 27 number number NN cord-304487-ycvu5l5f 35 28 and and CC cord-304487-ycvu5l5f 35 29 frequency frequency NN cord-304487-ycvu5l5f 35 30 of of IN cord-304487-ycvu5l5f 35 31 minority minority NN cord-304487-ycvu5l5f 35 32 variants variant NNS cord-304487-ycvu5l5f 35 33 within within IN cord-304487-ycvu5l5f 35 34 different different JJ cord-304487-ycvu5l5f 35 35 individuals individual NNS cord-304487-ycvu5l5f 35 36 . . . cord-304487-ycvu5l5f 36 1 Remarkably remarkably RB cord-304487-ycvu5l5f 36 2 , , , cord-304487-ycvu5l5f 36 3 despite despite IN cord-304487-ycvu5l5f 36 4 the the DT cord-304487-ycvu5l5f 36 5 limited limited JJ cord-304487-ycvu5l5f 36 6 number number NN cord-304487-ycvu5l5f 36 7 of of IN cord-304487-ycvu5l5f 36 8 individuals individual NNS cord-304487-ycvu5l5f 36 9 included include VBN cord-304487-ycvu5l5f 36 10 , , , cord-304487-ycvu5l5f 36 11 they -PRON- PRP cord-304487-ycvu5l5f 36 12 found find VBD cord-304487-ycvu5l5f 36 13 many many JJ cord-304487-ycvu5l5f 36 14 of of IN cord-304487-ycvu5l5f 36 15 the the DT cord-304487-ycvu5l5f 36 16 same same JJ cord-304487-ycvu5l5f 36 17 minority minority NN cord-304487-ycvu5l5f 36 18 variants variant NNS cord-304487-ycvu5l5f 36 19 in in IN cord-304487-ycvu5l5f 36 20 different different JJ cord-304487-ycvu5l5f 36 21 , , , cord-304487-ycvu5l5f 36 22 epidemiologically epidemiologically RB cord-304487-ycvu5l5f 36 23 unrelated unrelated JJ cord-304487-ycvu5l5f 36 24 individuals individual NNS cord-304487-ycvu5l5f 36 25 . . . cord-304487-ycvu5l5f 37 1 This this DT cord-304487-ycvu5l5f 37 2 pattern pattern NN cord-304487-ycvu5l5f 37 3 suggests suggest VBZ cord-304487-ycvu5l5f 37 4 that that IN cord-304487-ycvu5l5f 37 5 SARS SARS NNP cord-304487-ycvu5l5f 37 6 - - HYPH cord-304487-ycvu5l5f 37 7 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 37 8 is be VBZ cord-304487-ycvu5l5f 37 9 predisposed predispose VBN cord-304487-ycvu5l5f 37 10 towards towards IN cord-304487-ycvu5l5f 37 11 particular particular JJ cord-304487-ycvu5l5f 37 12 mutations mutation NNS cord-304487-ycvu5l5f 37 13 , , , cord-304487-ycvu5l5f 37 14 which which WDT cord-304487-ycvu5l5f 37 15 may may MD cord-304487-ycvu5l5f 37 16 continue continue VB cord-304487-ycvu5l5f 37 17 to to TO cord-304487-ycvu5l5f 37 18 re re VB cord-304487-ycvu5l5f 37 19 - - VB cord-304487-ycvu5l5f 37 20 appear appear VB cord-304487-ycvu5l5f 37 21 as as IN cord-304487-ycvu5l5f 37 22 the the DT cord-304487-ycvu5l5f 37 23 virus virus NN cord-304487-ycvu5l5f 37 24 continues continue VBZ cord-304487-ycvu5l5f 37 25 to to TO cord-304487-ycvu5l5f 37 26 spread spread VB cord-304487-ycvu5l5f 37 27 . . . cord-304487-ycvu5l5f 38 1 Recombination recombination NN cord-304487-ycvu5l5f 38 2 is be VBZ cord-304487-ycvu5l5f 38 3 an an DT cord-304487-ycvu5l5f 38 4 ongoing ongoing JJ cord-304487-ycvu5l5f 38 5 process process NN cord-304487-ycvu5l5f 38 6 in in IN cord-304487-ycvu5l5f 38 7 positive positive JJ cord-304487-ycvu5l5f 38 8 - - HYPH cord-304487-ycvu5l5f 38 9 strand strand NN cord-304487-ycvu5l5f 38 10 RNA RNA NNP cord-304487-ycvu5l5f 38 11 viruses virus NNS cord-304487-ycvu5l5f 38 12 [ [ -LRB- cord-304487-ycvu5l5f 38 13 5 5 CD cord-304487-ycvu5l5f 38 14 ] ] -RRB- cord-304487-ycvu5l5f 38 15 , , , cord-304487-ycvu5l5f 38 16 and and CC cord-304487-ycvu5l5f 38 17 coronaviruses coronaviruse NNS cord-304487-ycvu5l5f 38 18 are be VBP cord-304487-ycvu5l5f 38 19 no no DT cord-304487-ycvu5l5f 38 20 exception exception NN cord-304487-ycvu5l5f 38 21 . . . cord-304487-ycvu5l5f 39 1 The the DT cord-304487-ycvu5l5f 39 2 evolutionary evolutionary JJ cord-304487-ycvu5l5f 39 3 history history NN cord-304487-ycvu5l5f 39 4 of of IN cord-304487-ycvu5l5f 39 5 MERS MERS NNP cord-304487-ycvu5l5f 39 6 - - HYPH cord-304487-ycvu5l5f 39 7 CoV CoV NNP cord-304487-ycvu5l5f 39 8 in in IN cord-304487-ycvu5l5f 39 9 its -PRON- PRP$ cord-304487-ycvu5l5f 39 10 intermediate intermediate JJ cord-304487-ycvu5l5f 39 11 host host NN cord-304487-ycvu5l5f 39 12 , , , cord-304487-ycvu5l5f 39 13 camels camel NNS cord-304487-ycvu5l5f 39 14 , , , cord-304487-ycvu5l5f 39 15 is be VBZ cord-304487-ycvu5l5f 39 16 littered litter VBN cord-304487-ycvu5l5f 39 17 with with IN cord-304487-ycvu5l5f 39 18 recombination recombination NN cord-304487-ycvu5l5f 39 19 events event NNS cord-304487-ycvu5l5f 39 20 [ [ -LRB- cord-304487-ycvu5l5f 39 21 6 6 CD cord-304487-ycvu5l5f 39 22 ] ] -RRB- cord-304487-ycvu5l5f 39 23 . . . cord-304487-ycvu5l5f 40 1 The the DT cord-304487-ycvu5l5f 40 2 bat bat NN cord-304487-ycvu5l5f 40 3 coronaviruses coronaviruse NNS cord-304487-ycvu5l5f 40 4 from from IN cord-304487-ycvu5l5f 40 5 which which WDT cord-304487-ycvu5l5f 40 6 SARS SARS NNP cord-304487-ycvu5l5f 40 7 - - HYPH cord-304487-ycvu5l5f 40 8 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 40 9 descends descend VBZ cord-304487-ycvu5l5f 40 10 also also RB cord-304487-ycvu5l5f 40 11 betray betray VB cord-304487-ycvu5l5f 40 12 a a DT cord-304487-ycvu5l5f 40 13 history history NN cord-304487-ycvu5l5f 40 14 of of IN cord-304487-ycvu5l5f 40 15 recombination recombination NN cord-304487-ycvu5l5f 40 16 [ [ -LRB- cord-304487-ycvu5l5f 40 17 1 1 CD cord-304487-ycvu5l5f 40 18 ] ] -RRB- cord-304487-ycvu5l5f 40 19 , , , cord-304487-ycvu5l5f 40 20 although although IN cord-304487-ycvu5l5f 40 21 there there EX cord-304487-ycvu5l5f 40 22 does do VBZ cord-304487-ycvu5l5f 40 23 not not RB cord-304487-ycvu5l5f 40 24 appear appear VB cord-304487-ycvu5l5f 40 25 to to TO cord-304487-ycvu5l5f 40 26 have have VB cord-304487-ycvu5l5f 40 27 been be VBN cord-304487-ycvu5l5f 40 28 recombination recombination NN cord-304487-ycvu5l5f 40 29 distinguishing distinguish VBG cord-304487-ycvu5l5f 40 30 SARS SARS NNP cord-304487-ycvu5l5f 40 31 - - HYPH cord-304487-ycvu5l5f 40 32 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 40 33 from from IN cord-304487-ycvu5l5f 40 34 its -PRON- PRP$ cord-304487-ycvu5l5f 40 35 closest close JJS cord-304487-ycvu5l5f 40 36 described describe VBN cord-304487-ycvu5l5f 40 37 relative relative NN cord-304487-ycvu5l5f 40 38 in in IN cord-304487-ycvu5l5f 40 39 bats bat NNS cord-304487-ycvu5l5f 40 40 [ [ -LRB- cord-304487-ycvu5l5f 40 41 7 7 CD cord-304487-ycvu5l5f 40 42 ] ] -RRB- cord-304487-ycvu5l5f 40 43 . . . cord-304487-ycvu5l5f 41 1 In in IN cord-304487-ycvu5l5f 41 2 contrast contrast NN cord-304487-ycvu5l5f 41 3 , , , cord-304487-ycvu5l5f 41 4 the the DT cord-304487-ycvu5l5f 41 5 phylogeny phylogeny NN cord-304487-ycvu5l5f 41 6 for for IN cord-304487-ycvu5l5f 41 7 the the DT cord-304487-ycvu5l5f 41 8 first first JJ cord-304487-ycvu5l5f 41 9 SARS SARS NNP cord-304487-ycvu5l5f 41 10 - - HYPH cord-304487-ycvu5l5f 41 11 CoV CoV NNP cord-304487-ycvu5l5f 41 12 , , , cord-304487-ycvu5l5f 41 13 which which WDT cord-304487-ycvu5l5f 41 14 emerged emerge VBD cord-304487-ycvu5l5f 41 15 in in IN cord-304487-ycvu5l5f 41 16 2002 2002 CD cord-304487-ycvu5l5f 41 17 , , , cord-304487-ycvu5l5f 41 18 does do VBZ cord-304487-ycvu5l5f 41 19 not not RB cord-304487-ycvu5l5f 41 20 display display VB cord-304487-ycvu5l5f 41 21 evidence evidence NN cord-304487-ycvu5l5f 41 22 for for IN cord-304487-ycvu5l5f 41 23 recombination recombination NN cord-304487-ycvu5l5f 41 24 . . . cord-304487-ycvu5l5f 42 1 It -PRON- PRP cord-304487-ycvu5l5f 42 2 is be VBZ cord-304487-ycvu5l5f 42 3 unlikely unlikely JJ cord-304487-ycvu5l5f 42 4 that that IN cord-304487-ycvu5l5f 42 5 this this DT cord-304487-ycvu5l5f 42 6 virus virus NN cord-304487-ycvu5l5f 42 7 lacked lack VBD cord-304487-ycvu5l5f 42 8 the the DT cord-304487-ycvu5l5f 42 9 capacity capacity NN cord-304487-ycvu5l5f 42 10 for for IN cord-304487-ycvu5l5f 42 11 recombination recombination NN cord-304487-ycvu5l5f 42 12 , , , cord-304487-ycvu5l5f 42 13 only only RB cord-304487-ycvu5l5f 42 14 the the DT cord-304487-ycvu5l5f 42 15 opportunity opportunity NN cord-304487-ycvu5l5f 42 16 . . . cord-304487-ycvu5l5f 43 1 SARS SARS NNP cord-304487-ycvu5l5f 43 2 - - HYPH cord-304487-ycvu5l5f 43 3 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 43 4 is be VBZ cord-304487-ycvu5l5f 43 5 presumably presumably RB cord-304487-ycvu5l5f 43 6 constantly constantly RB cord-304487-ycvu5l5f 43 7 recombining recombine VBG cord-304487-ycvu5l5f 43 8 with with IN cord-304487-ycvu5l5f 43 9 itself -PRON- PRP cord-304487-ycvu5l5f 43 10 within within IN cord-304487-ycvu5l5f 43 11 every every DT cord-304487-ycvu5l5f 43 12 infected infect VBN cord-304487-ycvu5l5f 43 13 individual individual NN cord-304487-ycvu5l5f 43 14 . . . cord-304487-ycvu5l5f 44 1 However however RB cord-304487-ycvu5l5f 44 2 , , , cord-304487-ycvu5l5f 44 3 a a DT cord-304487-ycvu5l5f 44 4 homogenous homogenous JJ cord-304487-ycvu5l5f 44 5 population population NN cord-304487-ycvu5l5f 44 6 of of IN cord-304487-ycvu5l5f 44 7 viruses virus NNS cord-304487-ycvu5l5f 44 8 recombining recombine VBG cord-304487-ycvu5l5f 44 9 with with IN cord-304487-ycvu5l5f 44 10 nearly nearly RB cord-304487-ycvu5l5f 44 11 identical identical JJ cord-304487-ycvu5l5f 44 12 relatives relative NNS cord-304487-ycvu5l5f 44 13 will will MD cord-304487-ycvu5l5f 44 14 not not RB cord-304487-ycvu5l5f 44 15 produce produce VB cord-304487-ycvu5l5f 44 16 any any DT cord-304487-ycvu5l5f 44 17 novel novel JJ cord-304487-ycvu5l5f 44 18 genetic genetic JJ cord-304487-ycvu5l5f 44 19 combinations combination NNS cord-304487-ycvu5l5f 44 20 . . . cord-304487-ycvu5l5f 45 1 Genetic genetic JJ cord-304487-ycvu5l5f 45 2 recombination recombination NN cord-304487-ycvu5l5f 45 3 has have VBZ cord-304487-ycvu5l5f 45 4 biological biological JJ cord-304487-ycvu5l5f 45 5 and and CC cord-304487-ycvu5l5f 45 6 evolutionary evolutionary JJ cord-304487-ycvu5l5f 45 7 consequences consequence NNS cord-304487-ycvu5l5f 45 8 only only RB cord-304487-ycvu5l5f 45 9 when when WRB cord-304487-ycvu5l5f 45 10 the the DT cord-304487-ycvu5l5f 45 11 two two CD cord-304487-ycvu5l5f 45 12 recombining recombine VBG cord-304487-ycvu5l5f 45 13 viruses virus NNS cord-304487-ycvu5l5f 45 14 are be VBP cord-304487-ycvu5l5f 45 15 sufficiently sufficiently RB cord-304487-ycvu5l5f 45 16 genetically genetically RB cord-304487-ycvu5l5f 45 17 distinct distinct JJ cord-304487-ycvu5l5f 45 18 . . . cord-304487-ycvu5l5f 46 1 In in IN cord-304487-ycvu5l5f 46 2 Yi Yi NNP cord-304487-ycvu5l5f 46 3 's 's POS cord-304487-ycvu5l5f 46 4 article article NN cord-304487-ycvu5l5f 46 5 , , , cord-304487-ycvu5l5f 46 6 the the DT cord-304487-ycvu5l5f 46 7 prospect prospect NN cord-304487-ycvu5l5f 46 8 of of IN cord-304487-ycvu5l5f 46 9 recombination recombination NN cord-304487-ycvu5l5f 46 10 between between IN cord-304487-ycvu5l5f 46 11 genetically genetically RB cord-304487-ycvu5l5f 46 12 distinct distinct JJ cord-304487-ycvu5l5f 46 13 SARS SARS NNP cord-304487-ycvu5l5f 46 14 - - HYPH cord-304487-ycvu5l5f 46 15 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 46 16 strains strain NNS cord-304487-ycvu5l5f 46 17 is be VBZ cord-304487-ycvu5l5f 46 18 investigated investigate VBN cord-304487-ycvu5l5f 46 19 . . . cord-304487-ycvu5l5f 47 1 Robust robust JJ cord-304487-ycvu5l5f 47 2 phylogenetic phylogenetic JJ cord-304487-ycvu5l5f 47 3 testing testing NN cord-304487-ycvu5l5f 47 4 for for IN cord-304487-ycvu5l5f 47 5 recombination recombination NN cord-304487-ycvu5l5f 47 6 can can MD cord-304487-ycvu5l5f 47 7 not not RB cord-304487-ycvu5l5f 47 8 be be VB cord-304487-ycvu5l5f 47 9 performed perform VBN cord-304487-ycvu5l5f 47 10 on on IN cord-304487-ycvu5l5f 47 11 such such JJ cord-304487-ycvu5l5f 47 12 closely closely RB cord-304487-ycvu5l5f 47 13 related related JJ cord-304487-ycvu5l5f 47 14 viruses virus NNS cord-304487-ycvu5l5f 47 15 , , , cord-304487-ycvu5l5f 47 16 so so RB cord-304487-ycvu5l5f 47 17 Yi Yi NNP cord-304487-ycvu5l5f 47 18 relies rely VBZ cord-304487-ycvu5l5f 47 19 on on IN cord-304487-ycvu5l5f 47 20 detecting detect VBG cord-304487-ycvu5l5f 47 21 cycles cycle NNS cord-304487-ycvu5l5f 47 22 in in IN cord-304487-ycvu5l5f 47 23 haplotype haplotype NN cord-304487-ycvu5l5f 47 24 maps map NNS cord-304487-ycvu5l5f 47 25 . . . cord-304487-ycvu5l5f 48 1 These these DT cord-304487-ycvu5l5f 48 2 cycles cycle NNS cord-304487-ycvu5l5f 48 3 represent represent VBP cord-304487-ycvu5l5f 48 4 potentially potentially RB cord-304487-ycvu5l5f 48 5 non non JJ cord-304487-ycvu5l5f 48 6 - - JJ cord-304487-ycvu5l5f 48 7 linear linear JJ cord-304487-ycvu5l5f 48 8 evolutionary evolutionary JJ cord-304487-ycvu5l5f 48 9 histories history NNS cord-304487-ycvu5l5f 48 10 of of IN cord-304487-ycvu5l5f 48 11 viral viral JJ cord-304487-ycvu5l5f 48 12 evolution evolution NN cord-304487-ycvu5l5f 48 13 that that WDT cord-304487-ycvu5l5f 48 14 is be VBZ cord-304487-ycvu5l5f 48 15 consistent consistent JJ cord-304487-ycvu5l5f 48 16 with with IN cord-304487-ycvu5l5f 48 17 recombination recombination NN cord-304487-ycvu5l5f 48 18 . . . cord-304487-ycvu5l5f 49 1 However however RB cord-304487-ycvu5l5f 49 2 , , , cord-304487-ycvu5l5f 49 3 among among IN cord-304487-ycvu5l5f 49 4 such such JJ cord-304487-ycvu5l5f 49 5 closely closely RB cord-304487-ycvu5l5f 49 6 related related JJ cord-304487-ycvu5l5f 49 7 strains strain NNS cord-304487-ycvu5l5f 49 8 , , , cord-304487-ycvu5l5f 49 9 the the DT cord-304487-ycvu5l5f 49 10 signal signal NN cord-304487-ycvu5l5f 49 11 for for IN cord-304487-ycvu5l5f 49 12 recombination recombination NN cord-304487-ycvu5l5f 49 13 can can MD cord-304487-ycvu5l5f 49 14 not not RB cord-304487-ycvu5l5f 49 15 be be VB cord-304487-ycvu5l5f 49 16 reliably reliably RB cord-304487-ycvu5l5f 49 17 disentangled disentangle VBN cord-304487-ycvu5l5f 49 18 from from IN cord-304487-ycvu5l5f 49 19 convergent convergent JJ cord-304487-ycvu5l5f 49 20 evolution evolution NN cord-304487-ycvu5l5f 49 21 . . . cord-304487-ycvu5l5f 50 1 A a DT cord-304487-ycvu5l5f 50 2 scenario scenario NN cord-304487-ycvu5l5f 50 3 for for IN cord-304487-ycvu5l5f 50 4 convergent convergent JJ cord-304487-ycvu5l5f 50 5 evolution evolution NN cord-304487-ycvu5l5f 50 6 is be VBZ cord-304487-ycvu5l5f 50 7 plausible plausible JJ cord-304487-ycvu5l5f 50 8 based base VBN cord-304487-ycvu5l5f 50 9 the the DT cord-304487-ycvu5l5f 50 10 observation observation NN cord-304487-ycvu5l5f 50 11 of of IN cord-304487-ycvu5l5f 50 12 recurrent recurrent JJ cord-304487-ycvu5l5f 50 13 minority minority NN cord-304487-ycvu5l5f 50 14 variants variant NNS cord-304487-ycvu5l5f 50 15 reported report VBN cord-304487-ycvu5l5f 50 16 by by IN cord-304487-ycvu5l5f 50 17 Li Li NNP cord-304487-ycvu5l5f 50 18 et et NNP cord-304487-ycvu5l5f 50 19 al al NNP cord-304487-ycvu5l5f 50 20 . . . cord-304487-ycvu5l5f 51 1 Nonetheless nonetheless RB cord-304487-ycvu5l5f 51 2 , , , cord-304487-ycvu5l5f 51 3 as as IN cord-304487-ycvu5l5f 51 4 more more JJR cord-304487-ycvu5l5f 51 5 SARS SARS NNP cord-304487-ycvu5l5f 51 6 - - HYPH cord-304487-ycvu5l5f 51 7 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 51 8 genomes genome NNS cord-304487-ycvu5l5f 51 9 are be VBP cord-304487-ycvu5l5f 51 10 sequenced sequence VBN cord-304487-ycvu5l5f 51 11 and and CC cord-304487-ycvu5l5f 51 12 analyzed analyze VBN cord-304487-ycvu5l5f 51 13 , , , cord-304487-ycvu5l5f 51 14 a a DT cord-304487-ycvu5l5f 51 15 clearer clear JJR cord-304487-ycvu5l5f 51 16 picture picture NN cord-304487-ycvu5l5f 51 17 of of IN cord-304487-ycvu5l5f 51 18 the the DT cord-304487-ycvu5l5f 51 19 role role NN cord-304487-ycvu5l5f 51 20 recombination recombination NN cord-304487-ycvu5l5f 51 21 plays play VBZ cord-304487-ycvu5l5f 51 22 in in IN cord-304487-ycvu5l5f 51 23 SARS SARS NNP cord-304487-ycvu5l5f 51 24 - - HYPH cord-304487-ycvu5l5f 51 25 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 51 26 will will MD cord-304487-ycvu5l5f 51 27 likely likely RB cord-304487-ycvu5l5f 51 28 emerge emerge VB cord-304487-ycvu5l5f 51 29 . . . cord-304487-ycvu5l5f 52 1 The the DT cord-304487-ycvu5l5f 52 2 impact impact NN cord-304487-ycvu5l5f 52 3 of of IN cord-304487-ycvu5l5f 52 4 this this DT cord-304487-ycvu5l5f 52 5 increasing increase VBG cord-304487-ycvu5l5f 52 6 genetic genetic JJ cord-304487-ycvu5l5f 52 7 diversity diversity NN cord-304487-ycvu5l5f 52 8 on on IN cord-304487-ycvu5l5f 52 9 a a DT cord-304487-ycvu5l5f 52 10 hypothetical hypothetical JJ cord-304487-ycvu5l5f 52 11 vaccine vaccine NN cord-304487-ycvu5l5f 52 12 design design NN cord-304487-ycvu5l5f 52 13 is be VBZ cord-304487-ycvu5l5f 52 14 likely likely RB cord-304487-ycvu5l5f 52 15 minimal minimal JJ cord-304487-ycvu5l5f 52 16 . . . cord-304487-ycvu5l5f 53 1 Vaccine vaccine NN cord-304487-ycvu5l5f 53 2 efficacy efficacy NN cord-304487-ycvu5l5f 53 3 endures endure VBZ cord-304487-ycvu5l5f 53 4 against against IN cord-304487-ycvu5l5f 53 5 circulating circulate VBG cord-304487-ycvu5l5f 53 6 human human JJ cord-304487-ycvu5l5f 53 7 RNA RNA NNP cord-304487-ycvu5l5f 53 8 viruses virus NNS cord-304487-ycvu5l5f 53 9 that that WDT cord-304487-ycvu5l5f 53 10 have have VBP cord-304487-ycvu5l5f 53 11 accumulated accumulate VBN cord-304487-ycvu5l5f 53 12 decades decade NNS cord-304487-ycvu5l5f 53 13 of of IN cord-304487-ycvu5l5f 53 14 evolutionary evolutionary JJ cord-304487-ycvu5l5f 53 15 diversity diversity NN cord-304487-ycvu5l5f 53 16 ( ( -LRB- cord-304487-ycvu5l5f 53 17 e.g. e.g. RB cord-304487-ycvu5l5f 53 18 , , , cord-304487-ycvu5l5f 53 19 measles measle NNS cord-304487-ycvu5l5f 53 20 and and CC cord-304487-ycvu5l5f 53 21 polio polio NN cord-304487-ycvu5l5f 53 22 virus virus NN cord-304487-ycvu5l5f 53 23 ) ) -RRB- cord-304487-ycvu5l5f 53 24 . . . cord-304487-ycvu5l5f 54 1 The the DT cord-304487-ycvu5l5f 54 2 obvious obvious JJ cord-304487-ycvu5l5f 54 3 exceptions exception NNS cord-304487-ycvu5l5f 54 4 to to IN cord-304487-ycvu5l5f 54 5 this this DT cord-304487-ycvu5l5f 54 6 endurance endurance NN cord-304487-ycvu5l5f 54 7 are be VBP cord-304487-ycvu5l5f 54 8 seasonal seasonal JJ cord-304487-ycvu5l5f 54 9 influenza influenza NN cord-304487-ycvu5l5f 54 10 viruses virus NNS cord-304487-ycvu5l5f 54 11 , , , cord-304487-ycvu5l5f 54 12 where where WRB cord-304487-ycvu5l5f 54 13 protective protective JJ cord-304487-ycvu5l5f 54 14 immunity immunity NN cord-304487-ycvu5l5f 54 15 extends extend VBZ cord-304487-ycvu5l5f 54 16 over over RP cord-304487-ycvu5l5f 54 17 only only RB cord-304487-ycvu5l5f 54 18 a a DT cord-304487-ycvu5l5f 54 19 matter matter NN cord-304487-ycvu5l5f 54 20 of of IN cord-304487-ycvu5l5f 54 21 years year NNS cord-304487-ycvu5l5f 54 22 of of IN cord-304487-ycvu5l5f 54 23 viral viral JJ cord-304487-ycvu5l5f 54 24 evolution evolution NN cord-304487-ycvu5l5f 54 25 . . . cord-304487-ycvu5l5f 55 1 Whether whether IN cord-304487-ycvu5l5f 55 2 a a DT cord-304487-ycvu5l5f 55 3 successful successful JJ cord-304487-ycvu5l5f 55 4 vaccine vaccine NN cord-304487-ycvu5l5f 55 5 is be VBZ cord-304487-ycvu5l5f 55 6 developed develop VBN cord-304487-ycvu5l5f 55 7 or or CC cord-304487-ycvu5l5f 55 8 SARS SARS NNP cord-304487-ycvu5l5f 55 9 - - HYPH cord-304487-ycvu5l5f 55 10 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 55 11 continues continue VBZ cord-304487-ycvu5l5f 55 12 to to TO cord-304487-ycvu5l5f 55 13 spread spread VB cord-304487-ycvu5l5f 55 14 remains remain NNS cord-304487-ycvu5l5f 55 15 to to TO cord-304487-ycvu5l5f 55 16 be be VB cord-304487-ycvu5l5f 55 17 seen see VBN cord-304487-ycvu5l5f 55 18 . . . cord-304487-ycvu5l5f 56 1 At at IN cord-304487-ycvu5l5f 56 2 the the DT cord-304487-ycvu5l5f 56 3 beginning beginning NN cord-304487-ycvu5l5f 56 4 of of IN cord-304487-ycvu5l5f 56 5 a a DT cord-304487-ycvu5l5f 56 6 zoonotic zoonotic JJ cord-304487-ycvu5l5f 56 7 event event NN cord-304487-ycvu5l5f 56 8 , , , cord-304487-ycvu5l5f 56 9 viral viral JJ cord-304487-ycvu5l5f 56 10 adaptation adaptation NN cord-304487-ycvu5l5f 56 11 is be VBZ cord-304487-ycvu5l5f 56 12 difficult difficult JJ cord-304487-ycvu5l5f 56 13 . . . cord-304487-ycvu5l5f 57 1 The the DT cord-304487-ycvu5l5f 57 2 viral viral JJ cord-304487-ycvu5l5f 57 3 effective effective JJ cord-304487-ycvu5l5f 57 4 population population NN cord-304487-ycvu5l5f 57 5 size size NN cord-304487-ycvu5l5f 57 6 ( ( -LRB- cord-304487-ycvu5l5f 57 7 an an DT cord-304487-ycvu5l5f 57 8 amalgam amalgam NN cord-304487-ycvu5l5f 57 9 of of IN cord-304487-ycvu5l5f 57 10 the the DT cord-304487-ycvu5l5f 57 11 number number NN cord-304487-ycvu5l5f 57 12 of of IN cord-304487-ycvu5l5f 57 13 productive productive JJ cord-304487-ycvu5l5f 57 14 infections infection NNS cord-304487-ycvu5l5f 57 15 and and CC cord-304487-ycvu5l5f 57 16 the the DT cord-304487-ycvu5l5f 57 17 genetic genetic JJ cord-304487-ycvu5l5f 57 18 diversity diversity NN cord-304487-ycvu5l5f 57 19 ) ) -RRB- cord-304487-ycvu5l5f 57 20 is be VBZ cord-304487-ycvu5l5f 57 21 low low JJ cord-304487-ycvu5l5f 57 22 ; ; : cord-304487-ycvu5l5f 57 23 thus thus RB cord-304487-ycvu5l5f 57 24 , , , cord-304487-ycvu5l5f 57 25 natural natural JJ cord-304487-ycvu5l5f 57 26 selection selection NN cord-304487-ycvu5l5f 57 27 will will MD cord-304487-ycvu5l5f 57 28 be be VB cord-304487-ycvu5l5f 57 29 inefficient inefficient JJ cord-304487-ycvu5l5f 57 30 , , , cord-304487-ycvu5l5f 57 31 and and CC cord-304487-ycvu5l5f 57 32 recombination recombination NN cord-304487-ycvu5l5f 57 33 will will MD cord-304487-ycvu5l5f 57 34 not not RB cord-304487-ycvu5l5f 57 35 result result VB cord-304487-ycvu5l5f 57 36 in in IN cord-304487-ycvu5l5f 57 37 particularly particularly RB cord-304487-ycvu5l5f 57 38 novel novel JJ cord-304487-ycvu5l5f 57 39 combinations combination NNS cord-304487-ycvu5l5f 57 40 . . . cord-304487-ycvu5l5f 58 1 However however RB cord-304487-ycvu5l5f 58 2 , , , cord-304487-ycvu5l5f 58 3 as as IN cord-304487-ycvu5l5f 58 4 the the DT cord-304487-ycvu5l5f 58 5 number number NN cord-304487-ycvu5l5f 58 6 of of IN cord-304487-ycvu5l5f 58 7 infections infection NNS cord-304487-ycvu5l5f 58 8 increases increase NNS cord-304487-ycvu5l5f 58 9 and and CC cord-304487-ycvu5l5f 58 10 the the DT cord-304487-ycvu5l5f 58 11 circulating circulate VBG cord-304487-ycvu5l5f 58 12 viruses virus NNS cord-304487-ycvu5l5f 58 13 become become VBP cord-304487-ycvu5l5f 58 14 more more RBR cord-304487-ycvu5l5f 58 15 genetically genetically RB cord-304487-ycvu5l5f 58 16 distinct distinct JJ cord-304487-ycvu5l5f 58 17 , , , cord-304487-ycvu5l5f 58 18 natural natural JJ cord-304487-ycvu5l5f 58 19 selection selection NN cord-304487-ycvu5l5f 58 20 will will MD cord-304487-ycvu5l5f 58 21 become become VB cord-304487-ycvu5l5f 58 22 more more RBR cord-304487-ycvu5l5f 58 23 efficient efficient JJ cord-304487-ycvu5l5f 58 24 , , , cord-304487-ycvu5l5f 58 25 making make VBG cord-304487-ycvu5l5f 58 26 viral viral JJ cord-304487-ycvu5l5f 58 27 adaptation adaptation NN cord-304487-ycvu5l5f 58 28 more more JJR cord-304487-ycvu5l5f 58 29 of of IN cord-304487-ycvu5l5f 58 30 a a DT cord-304487-ycvu5l5f 58 31 possibility possibility NN cord-304487-ycvu5l5f 58 32 . . . cord-304487-ycvu5l5f 59 1 Nonetheless nonetheless RB cord-304487-ycvu5l5f 59 2 , , , cord-304487-ycvu5l5f 59 3 when when WRB cord-304487-ycvu5l5f 59 4 SARS SARS NNP cord-304487-ycvu5l5f 59 5 - - HYPH cord-304487-ycvu5l5f 59 6 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 59 7 arrived arrive VBD cord-304487-ycvu5l5f 59 8 in in IN cord-304487-ycvu5l5f 59 9 humans human NNS cord-304487-ycvu5l5f 59 10 , , , cord-304487-ycvu5l5f 59 11 it -PRON- PRP cord-304487-ycvu5l5f 59 12 was be VBD cord-304487-ycvu5l5f 59 13 already already RB cord-304487-ycvu5l5f 59 14 well well RB cord-304487-ycvu5l5f 59 15 suited suited JJ cord-304487-ycvu5l5f 59 16 for for IN cord-304487-ycvu5l5f 59 17 person person NN cord-304487-ycvu5l5f 59 18 - - HYPH cord-304487-ycvu5l5f 59 19 to to IN cord-304487-ycvu5l5f 59 20 - - HYPH cord-304487-ycvu5l5f 59 21 person person NN cord-304487-ycvu5l5f 59 22 transmission transmission NN cord-304487-ycvu5l5f 59 23 , , , cord-304487-ycvu5l5f 59 24 with with IN cord-304487-ycvu5l5f 59 25 pathogenic pathogenic JJ cord-304487-ycvu5l5f 59 26 consequences consequence NNS cord-304487-ycvu5l5f 59 27 . . . cord-304487-ycvu5l5f 60 1 Furthermore furthermore RB cord-304487-ycvu5l5f 60 2 , , , cord-304487-ycvu5l5f 60 3 it -PRON- PRP cord-304487-ycvu5l5f 60 4 is be VBZ cord-304487-ycvu5l5f 60 5 worth worth JJ cord-304487-ycvu5l5f 60 6 remembering remember VBG cord-304487-ycvu5l5f 60 7 that that IN cord-304487-ycvu5l5f 60 8 the the DT cord-304487-ycvu5l5f 60 9 evolutionary evolutionary JJ cord-304487-ycvu5l5f 60 10 landscape landscape NN cord-304487-ycvu5l5f 60 11 that that IN cord-304487-ycvu5l5f 60 12 SARS SARS NNP cord-304487-ycvu5l5f 60 13 - - HYPH cord-304487-ycvu5l5f 60 14 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 60 15 will will MD cord-304487-ycvu5l5f 60 16 explore explore VB cord-304487-ycvu5l5f 60 17 in in IN cord-304487-ycvu5l5f 60 18 humans human NNS cord-304487-ycvu5l5f 60 19 is be VBZ cord-304487-ycvu5l5f 60 20 dwarfed dwarf VBN cord-304487-ycvu5l5f 60 21 by by IN cord-304487-ycvu5l5f 60 22 its -PRON- PRP$ cord-304487-ycvu5l5f 60 23 previous previous JJ cord-304487-ycvu5l5f 60 24 exploration exploration NN cord-304487-ycvu5l5f 60 25 in in IN cord-304487-ycvu5l5f 60 26 bats bat NNS cord-304487-ycvu5l5f 60 27 . . . cord-304487-ycvu5l5f 61 1 For for IN cord-304487-ycvu5l5f 61 2 now now RB cord-304487-ycvu5l5f 61 3 , , , cord-304487-ycvu5l5f 61 4 SARS SARS NNP cord-304487-ycvu5l5f 61 5 - - HYPH cord-304487-ycvu5l5f 61 6 CoV-2 CoV-2 NNP cord-304487-ycvu5l5f 61 7 genetic genetic JJ cord-304487-ycvu5l5f 61 8 variation variation NN cord-304487-ycvu5l5f 61 9 is be VBZ cord-304487-ycvu5l5f 61 10 likely likely RB cord-304487-ycvu5l5f 61 11 evolutionarily evolutionarily RB cord-304487-ycvu5l5f 61 12 inconsequential inconsequential JJ cord-304487-ycvu5l5f 61 13 and and CC cord-304487-ycvu5l5f 61 14 will will MD cord-304487-ycvu5l5f 61 15 be be VB cord-304487-ycvu5l5f 61 16 more more RBR cord-304487-ycvu5l5f 61 17 important important JJ cord-304487-ycvu5l5f 61 18 for for IN cord-304487-ycvu5l5f 61 19 facilitating facilitate VBG cord-304487-ycvu5l5f 61 20 molecular molecular JJ cord-304487-ycvu5l5f 61 21 epidemiology epidemiology NN cord-304487-ycvu5l5f 61 22 in in IN cord-304487-ycvu5l5f 61 23 tracing trace VBG cord-304487-ycvu5l5f 61 24 the the DT cord-304487-ycvu5l5f 61 25 origins origin NNS cord-304487-ycvu5l5f 61 26 of of IN cord-304487-ycvu5l5f 61 27 novel novel JJ cord-304487-ycvu5l5f 61 28 clusters cluster NNS cord-304487-ycvu5l5f 61 29 of of IN cord-304487-ycvu5l5f 61 30 viral viral JJ cord-304487-ycvu5l5f 61 31 infection infection NN cord-304487-ycvu5l5f 61 32 . . . cord-304487-ycvu5l5f 62 1 Dr. Dr. NNP cord-304487-ycvu5l5f 62 2 Wertheim Wertheim NNP cord-304487-ycvu5l5f 62 3 reports report VBZ cord-304487-ycvu5l5f 62 4 grants grant NNS cord-304487-ycvu5l5f 62 5 from from IN cord-304487-ycvu5l5f 62 6 National National NNP cord-304487-ycvu5l5f 62 7 Institutes Institutes NNPS cord-304487-ycvu5l5f 62 8 of of IN cord-304487-ycvu5l5f 62 9 Health Health NNP cord-304487-ycvu5l5f 62 10 ( ( -LRB- cord-304487-ycvu5l5f 62 11 NIH NIH NNP cord-304487-ycvu5l5f 62 12 ) ) -RRB- cord-304487-ycvu5l5f 62 13 , , , cord-304487-ycvu5l5f 62 14 and and CC cord-304487-ycvu5l5f 62 15 grants grant NNS cord-304487-ycvu5l5f 62 16 from from IN cord-304487-ycvu5l5f 62 17 Centers Centers NNPS cord-304487-ycvu5l5f 62 18 for for IN cord-304487-ycvu5l5f 62 19 Disease Disease NNP cord-304487-ycvu5l5f 62 20 Control Control NNP cord-304487-ycvu5l5f 62 21 and and CC cord-304487-ycvu5l5f 62 22 Prevention Prevention NNP cord-304487-ycvu5l5f 62 23 ( ( -LRB- cord-304487-ycvu5l5f 62 24 CDC CDC NNP cord-304487-ycvu5l5f 62 25 ) ) -RRB- cord-304487-ycvu5l5f 62 26 , , , cord-304487-ycvu5l5f 62 27 outside outside IN cord-304487-ycvu5l5f 62 28 the the DT cord-304487-ycvu5l5f 62 29 submitted submit VBN cord-304487-ycvu5l5f 62 30 work work NN cord-304487-ycvu5l5f 62 31 ; ; : cord-304487-ycvu5l5f 62 32 He -PRON- PRP cord-304487-ycvu5l5f 62 33 has have VBZ cord-304487-ycvu5l5f 62 34 no no DT cord-304487-ycvu5l5f 62 35 conflicts conflict NNS cord-304487-ycvu5l5f 62 36 of of IN cord-304487-ycvu5l5f 62 37 interest interest NN cord-304487-ycvu5l5f 62 38 to to TO cord-304487-ycvu5l5f 62 39 disclose disclose VB cord-304487-ycvu5l5f 62 40 . . . cord-304487-ycvu5l5f 63 1 Genomic genomic JJ cord-304487-ycvu5l5f 63 2 characterisation characterisation NN cord-304487-ycvu5l5f 63 3 and and CC cord-304487-ycvu5l5f 63 4 epidemiology epidemiology NN cord-304487-ycvu5l5f 63 5 of of IN cord-304487-ycvu5l5f 63 6 2019 2019 CD cord-304487-ycvu5l5f 63 7 novel novel JJ cord-304487-ycvu5l5f 63 8 coronavirus coronavirus NN cord-304487-ycvu5l5f 63 9 : : : cord-304487-ycvu5l5f 63 10 implications implication NNS cord-304487-ycvu5l5f 63 11 for for IN cord-304487-ycvu5l5f 63 12 virus virus NN cord-304487-ycvu5l5f 63 13 origins origin NNS cord-304487-ycvu5l5f 63 14 and and CC cord-304487-ycvu5l5f 63 15 receptor receptor NN cord-304487-ycvu5l5f 63 16 binding bind VBG cord-304487-ycvu5l5f 63 17 A a DT cord-304487-ycvu5l5f 63 18 pneumonia pneumonia NN cord-304487-ycvu5l5f 63 19 outbreak outbreak NN cord-304487-ycvu5l5f 63 20 associated associate VBN cord-304487-ycvu5l5f 63 21 with with IN cord-304487-ycvu5l5f 63 22 a a DT cord-304487-ycvu5l5f 63 23 new new JJ cord-304487-ycvu5l5f 63 24 coronavirus coronavirus NN cord-304487-ycvu5l5f 63 25 of of IN cord-304487-ycvu5l5f 63 26 probable probable JJ cord-304487-ycvu5l5f 63 27 bat bat NN cord-304487-ycvu5l5f 64 1 origin origin NNP cord-304487-ycvu5l5f 65 1 A a DT cord-304487-ycvu5l5f 65 2 case case NN cord-304487-ycvu5l5f 65 3 for for IN cord-304487-ycvu5l5f 65 4 the the DT cord-304487-ycvu5l5f 65 5 ancient ancient JJ cord-304487-ycvu5l5f 65 6 origin origin NN cord-304487-ycvu5l5f 65 7 of of IN cord-304487-ycvu5l5f 65 8 coronaviruses coronaviruse NNS cord-304487-ycvu5l5f 66 1 Identifying identify VBG cord-304487-ycvu5l5f 66 2 genetic genetic JJ cord-304487-ycvu5l5f 66 3 markers marker NNS cord-304487-ycvu5l5f 66 4 of of IN cord-304487-ycvu5l5f 66 5 adaptation adaptation NN cord-304487-ycvu5l5f 66 6 for for IN cord-304487-ycvu5l5f 66 7 surveillance surveillance NN cord-304487-ycvu5l5f 66 8 of of IN cord-304487-ycvu5l5f 66 9 viral viral JJ cord-304487-ycvu5l5f 66 10 host host NN cord-304487-ycvu5l5f 66 11 jumps jump VBZ cord-304487-ycvu5l5f 66 12 Evolutionary evolutionary JJ cord-304487-ycvu5l5f 66 13 aspects aspect NNS cord-304487-ycvu5l5f 66 14 of of IN cord-304487-ycvu5l5f 66 15 recombination recombination NN cord-304487-ycvu5l5f 66 16 in in IN cord-304487-ycvu5l5f 66 17 RNA RNA NNP cord-304487-ycvu5l5f 66 18 viruses virus NNS cord-304487-ycvu5l5f 66 19 MERS MERS NNP cord-304487-ycvu5l5f 66 20 - - HYPH cord-304487-ycvu5l5f 66 21 CoV cov NN cord-304487-ycvu5l5f 66 22 spillover spillover NN cord-304487-ycvu5l5f 66 23 at at IN cord-304487-ycvu5l5f 66 24 the the DT cord-304487-ycvu5l5f 66 25 camel camel NN cord-304487-ycvu5l5f 66 26 - - HYPH cord-304487-ycvu5l5f 66 27 human human NN cord-304487-ycvu5l5f 66 28 interface interface NN cord-304487-ycvu5l5f 66 29 Full full JJ cord-304487-ycvu5l5f 66 30 - - HYPH cord-304487-ycvu5l5f 66 31 genome genome NN cord-304487-ycvu5l5f 66 32 evolutionary evolutionary JJ cord-304487-ycvu5l5f 66 33 analysis analysis NN cord-304487-ycvu5l5f 66 34 of of IN cord-304487-ycvu5l5f 66 35 the the DT cord-304487-ycvu5l5f 66 36 novel novel JJ cord-304487-ycvu5l5f 66 37 corona corona NN cord-304487-ycvu5l5f 66 38 virus virus NN cord-304487-ycvu5l5f 66 39 ( ( -LRB- cord-304487-ycvu5l5f 66 40 2019-nCoV 2019-ncov CD cord-304487-ycvu5l5f 66 41 ) ) -RRB- cord-304487-ycvu5l5f 67 1 rejects reject VBZ cord-304487-ycvu5l5f 67 2 the the DT cord-304487-ycvu5l5f 67 3 hypothesis hypothesis NN cord-304487-ycvu5l5f 67 4 of of IN cord-304487-ycvu5l5f 67 5 emergence emergence NN cord-304487-ycvu5l5f 67 6 as as IN cord-304487-ycvu5l5f 67 7 a a DT cord-304487-ycvu5l5f 67 8 result result NN cord-304487-ycvu5l5f 67 9 of of IN cord-304487-ycvu5l5f 67 10 a a DT cord-304487-ycvu5l5f 67 11 recent recent JJ cord-304487-ycvu5l5f 67 12 recombination recombination NN cord-304487-ycvu5l5f 67 13 event event NN