id	sid	tid	token	lemma	pos
cord-279932-bilr71ay	1	1	key	key	JJ
cord-279932-bilr71ay	1	2	:	:	:
cord-279932-bilr71ay	1	3	cord-279932-bilr71ay	cord-279932-bilr71ay	NN
cord-279932-bilr71ay	1	4	authors	author	NNS
cord-279932-bilr71ay	1	5	:	:	:
cord-279932-bilr71ay	1	6	Plotkin	Plotkin	NNP
cord-279932-bilr71ay	1	7	,	,	,
cord-279932-bilr71ay	1	8	Stanley	Stanley	NNP
cord-279932-bilr71ay	1	9	A	a	DT
cord-279932-bilr71ay	1	10	title	title	NN
cord-279932-bilr71ay	1	11	:	:	:
cord-279932-bilr71ay	1	12	The	the	DT
cord-279932-bilr71ay	1	13	Value	Value	NNP
cord-279932-bilr71ay	1	14	of	of	IN
cord-279932-bilr71ay	1	15	Human	Human	NNP
cord-279932-bilr71ay	1	16	Challenges	Challenges	NNPS
cord-279932-bilr71ay	1	17	in	in	IN
cord-279932-bilr71ay	1	18	Severe	severe	JJ
cord-279932-bilr71ay	1	19	Acute	acute	JJ
cord-279932-bilr71ay	1	20	Respiratory	Respiratory	NNP
cord-279932-bilr71ay	1	21	Syndrome	Syndrome	NNP
cord-279932-bilr71ay	1	22	Coronavirus	Coronavirus	NNP
cord-279932-bilr71ay	1	23	2	2	CD
cord-279932-bilr71ay	1	24	Vaccine	Vaccine	NNP
cord-279932-bilr71ay	1	25	Development	Development	NNP
cord-279932-bilr71ay	1	26	date	date	NN
cord-279932-bilr71ay	1	27	:	:	:
cord-279932-bilr71ay	1	28	2020	2020	CD
cord-279932-bilr71ay	1	29	-	-	HYPH
cord-279932-bilr71ay	1	30	07	07	CD
cord-279932-bilr71ay	1	31	-	-	HYPH
cord-279932-bilr71ay	1	32	16	16	CD
cord-279932-bilr71ay	1	33	journal	journal	NN
cord-279932-bilr71ay	1	34	:	:	:
cord-279932-bilr71ay	1	35	Clin	Clin	NNP
cord-279932-bilr71ay	1	36	Infect	infect	VB
cord-279932-bilr71ay	1	37	Dis	Dis	NNP
cord-279932-bilr71ay	1	38	DOI	doi	NN
cord-279932-bilr71ay	1	39	:	:	:
cord-279932-bilr71ay	1	40	10.1093	10.1093	CD
cord-279932-bilr71ay	1	41	/	/	SYM
cord-279932-bilr71ay	1	42	cid	cid	NN
cord-279932-bilr71ay	1	43	/	/	SYM
cord-279932-bilr71ay	1	44	ciaa1013	ciaa1013	NNP
cord-279932-bilr71ay	1	45	sha	sha	NNP
cord-279932-bilr71ay	1	46	:	:	:
cord-279932-bilr71ay	2	1	311c6288da3e04bc7867983220ff9864cb6cfd0f	311c6288da3e04bc7867983220ff9864cb6cfd0f	LS
cord-279932-bilr71ay	2	2	doc_id	doc_id	CD
cord-279932-bilr71ay	2	3	:	:	:
cord-279932-bilr71ay	2	4	279932	279932	CD
cord-279932-bilr71ay	2	5	cord_uid	cord_uid	NNS
cord-279932-bilr71ay	2	6	:	:	:
cord-279932-bilr71ay	2	7	bilr71ay	bilr71ay	NNP
cord-279932-bilr71ay	2	8	nan	nan	NNP
cord-279932-bilr71ay	2	9	1	1	CD
cord-279932-bilr71ay	2	10	Pediatrics	Pediatrics	NNP
cord-279932-bilr71ay	2	11	,	,	,
cord-279932-bilr71ay	2	12	University	University	NNP
cord-279932-bilr71ay	2	13	of	of	IN
cord-279932-bilr71ay	2	14	Pennsylvania	Pennsylvania	NNP
cord-279932-bilr71ay	2	15	,	,	,
cord-279932-bilr71ay	2	16	Vaxconsult	Vaxconsult	NNP
cord-279932-bilr71ay	2	17	,	,	,
cord-279932-bilr71ay	2	18	Doylestown	Doylestown	NNP
cord-279932-bilr71ay	2	19	,	,	,
cord-279932-bilr71ay	2	20	Pennsylvania	Pennsylvania	NNP
cord-279932-bilr71ay	2	21	,	,	,
cord-279932-bilr71ay	2	22	USA	USA	NNP
cord-279932-bilr71ay	2	23	,	,	,
cord-279932-bilr71ay	2	24	and	and	CC
cord-279932-bilr71ay	2	25	2	2	CD
cord-279932-bilr71ay	2	26	Sanofi	Sanofi	NNP
cord-279932-bilr71ay	2	27	Pasteur	Pasteur	NNP
cord-279932-bilr71ay	2	28	,	,	,
cord-279932-bilr71ay	2	29	Doylestown	Doylestown	NNP
cord-279932-bilr71ay	2	30	,	,	,
cord-279932-bilr71ay	2	31	Pennsylvania	Pennsylvania	NNP
cord-279932-bilr71ay	2	32	,	,	,
cord-279932-bilr71ay	2	33	USA	USA	NNP
cord-279932-bilr71ay	3	1	The	the	DT
cord-279932-bilr71ay	3	2	epidemic	epidemic	NN
cord-279932-bilr71ay	3	3	of	of	IN
cord-279932-bilr71ay	3	4	coronavirus	coronavirus	NN
cord-279932-bilr71ay	3	5	disease	disease	NN
cord-279932-bilr71ay	3	6	2019	2019	CD
cord-279932-bilr71ay	3	7	(	(	-LRB-
cord-279932-bilr71ay	3	8	COVID-19	COVID-19	NNP
cord-279932-bilr71ay	3	9	)	)	-RRB-
cord-279932-bilr71ay	3	10	rolls	roll	VBZ
cord-279932-bilr71ay	3	11	on	on	IN
cord-279932-bilr71ay	3	12	,	,	,
cord-279932-bilr71ay	3	13	at	at	IN
cord-279932-bilr71ay	3	14	least	least	JJS
cord-279932-bilr71ay	3	15	in	in	IN
cord-279932-bilr71ay	3	16	the	the	DT
cord-279932-bilr71ay	3	17	rulerecalcitrant	rulerecalcitrant	JJ
cord-279932-bilr71ay	3	18	population	population	NN
cord-279932-bilr71ay	3	19	of	of	IN
cord-279932-bilr71ay	3	20	the	the	DT
cord-279932-bilr71ay	3	21	United	United	NNP
cord-279932-bilr71ay	3	22	States	States	NNP
cord-279932-bilr71ay	3	23	,	,	,
cord-279932-bilr71ay	3	24	but	but	CC
cord-279932-bilr71ay	3	25	also	also	RB
cord-279932-bilr71ay	3	26	in	in	IN
cord-279932-bilr71ay	3	27	countries	country	NNS
cord-279932-bilr71ay	3	28	that	that	WDT
cord-279932-bilr71ay	3	29	are	be	VBP
cord-279932-bilr71ay	3	30	too	too	RB
cord-279932-bilr71ay	3	31	poor	poor	JJ
cord-279932-bilr71ay	3	32	and	and	CC
cord-279932-bilr71ay	3	33	disorganized	disorganized	JJ
cord-279932-bilr71ay	3	34	to	to	TO
cord-279932-bilr71ay	3	35	provide	provide	VB
cord-279932-bilr71ay	3	36	conditions	condition	NNS
cord-279932-bilr71ay	3	37	for	for	IN
cord-279932-bilr71ay	3	38	self	self	NN
cord-279932-bilr71ay	3	39	-	-	HYPH
cord-279932-bilr71ay	3	40	isolation	isolation	NN
cord-279932-bilr71ay	3	41	.	.	.
cord-279932-bilr71ay	4	1	Aside	aside	RB
cord-279932-bilr71ay	4	2	from	from	IN
cord-279932-bilr71ay	4	3	the	the	DT
cord-279932-bilr71ay	4	4	increasing	increase	VBG
cord-279932-bilr71ay	4	5	toll	toll	NN
cord-279932-bilr71ay	4	6	of	of	IN
cord-279932-bilr71ay	4	7	death	death	NN
cord-279932-bilr71ay	4	8	and	and	CC
cord-279932-bilr71ay	4	9	disability	disability	NN
cord-279932-bilr71ay	4	10	,	,	,
cord-279932-bilr71ay	4	11	the	the	DT
cord-279932-bilr71ay	4	12	economic	economic	JJ
cord-279932-bilr71ay	4	13	and	and	CC
cord-279932-bilr71ay	4	14	social	social	JJ
cord-279932-bilr71ay	4	15	effects	effect	NNS
cord-279932-bilr71ay	4	16	of	of	IN
cord-279932-bilr71ay	4	17	the	the	DT
cord-279932-bilr71ay	4	18	epidemic	epidemic	NN
cord-279932-bilr71ay	4	19	are	be	VBP
cord-279932-bilr71ay	4	20	disastrous	disastrous	JJ
cord-279932-bilr71ay	4	21	and	and	CC
cord-279932-bilr71ay	4	22	grow	grow	VB
cord-279932-bilr71ay	4	23	day	day	NN
cord-279932-bilr71ay	4	24	by	by	IN
cord-279932-bilr71ay	4	25	day	day	NN
cord-279932-bilr71ay	4	26	,	,	,
cord-279932-bilr71ay	4	27	exceeding	exceed	VBG
cord-279932-bilr71ay	4	28	anything	anything	NN
cord-279932-bilr71ay	4	29	seen	see	VBN
cord-279932-bilr71ay	4	30	since	since	IN
cord-279932-bilr71ay	4	31	the	the	DT
cord-279932-bilr71ay	4	32	1918	1918	CD
cord-279932-bilr71ay	4	33	-	-	SYM
cord-279932-bilr71ay	4	34	19	19	CD
cord-279932-bilr71ay	4	35	influenza	influenza	NN
cord-279932-bilr71ay	4	36	outbreak	outbreak	NN
cord-279932-bilr71ay	4	37	or	or	CC
cord-279932-bilr71ay	4	38	the	the	DT
cord-279932-bilr71ay	4	39	depression	depression	NN
cord-279932-bilr71ay	4	40	of	of	IN
cord-279932-bilr71ay	4	41	the	the	DT
cord-279932-bilr71ay	4	42	1930s	1930	NNS
cord-279932-bilr71ay	4	43	.	.	.
cord-279932-bilr71ay	5	1	We	-PRON-	PRP
cord-279932-bilr71ay	5	2	have	have	VBP
cord-279932-bilr71ay	5	3	only	only	RB
cord-279932-bilr71ay	5	4	2	2	CD
cord-279932-bilr71ay	5	5	hopes	hope	NNS
cord-279932-bilr71ay	5	6	for	for	IN
cord-279932-bilr71ay	5	7	salvation	salvation	NN
cord-279932-bilr71ay	5	8	:	:	:
cord-279932-bilr71ay	5	9	the	the	DT
cord-279932-bilr71ay	5	10	exhaustion	exhaustion	NN
cord-279932-bilr71ay	5	11	of	of	IN
cord-279932-bilr71ay	5	12	susceptible	susceptible	JJ
cord-279932-bilr71ay	5	13	individuals	individual	NNS
cord-279932-bilr71ay	5	14	by	by	IN
cord-279932-bilr71ay	5	15	natural	natural	JJ
cord-279932-bilr71ay	5	16	infections	infection	NNS
cord-279932-bilr71ay	5	17	or	or	CC
cord-279932-bilr71ay	5	18	the	the	DT
cord-279932-bilr71ay	5	19	development	development	NN
cord-279932-bilr71ay	5	20	of	of	IN
cord-279932-bilr71ay	5	21	a	a	DT
cord-279932-bilr71ay	5	22	preventive	preventive	JJ
cord-279932-bilr71ay	5	23	vaccine	vaccine	NN
cord-279932-bilr71ay	5	24	.	.	.
cord-279932-bilr71ay	6	1	The	the	DT
cord-279932-bilr71ay	6	2	former	former	JJ
cord-279932-bilr71ay	6	3	hope	hope	NN
cord-279932-bilr71ay	6	4	would	would	MD
cord-279932-bilr71ay	6	5	require	require	VB
cord-279932-bilr71ay	6	6	acceptance	acceptance	NN
cord-279932-bilr71ay	6	7	of	of	IN
cord-279932-bilr71ay	6	8	many	many	JJ
cord-279932-bilr71ay	6	9	deaths	death	NNS
cord-279932-bilr71ay	6	10	and	and	CC
cord-279932-bilr71ay	6	11	overflowing	overflow	VBG
cord-279932-bilr71ay	6	12	hospitals	hospital	NNS
cord-279932-bilr71ay	6	13	,	,	,
cord-279932-bilr71ay	6	14	while	while	IN
cord-279932-bilr71ay	6	15	the	the	DT
cord-279932-bilr71ay	6	16	latter	latter	JJ
cord-279932-bilr71ay	6	17	hope	hope	NN
cord-279932-bilr71ay	6	18	depends	depend	VBZ
cord-279932-bilr71ay	6	19	on	on	IN
cord-279932-bilr71ay	6	20	an	an	DT
cord-279932-bilr71ay	6	21	effective	effective	JJ
cord-279932-bilr71ay	6	22	vaccine	vaccine	NN
cord-279932-bilr71ay	6	23	being	be	VBG
cord-279932-bilr71ay	6	24	licensed	license	VBN
cord-279932-bilr71ay	6	25	for	for	IN
cord-279932-bilr71ay	6	26	widespread	widespread	JJ
cord-279932-bilr71ay	6	27	use	use	NN
cord-279932-bilr71ay	6	28	.	.	.
cord-279932-bilr71ay	7	1	Normally	normally	RB
cord-279932-bilr71ay	7	2	,	,	,
cord-279932-bilr71ay	7	3	licensure	licensure	NN
cord-279932-bilr71ay	7	4	of	of	IN
cord-279932-bilr71ay	7	5	a	a	DT
cord-279932-bilr71ay	7	6	vaccine	vaccine	NN
cord-279932-bilr71ay	7	7	requires	require	VBZ
cord-279932-bilr71ay	7	8	many	many	JJ
cord-279932-bilr71ay	7	9	years	year	NNS
cord-279932-bilr71ay	7	10	of	of	IN
cord-279932-bilr71ay	7	11	development	development	NN
cord-279932-bilr71ay	7	12	,	,	,
cord-279932-bilr71ay	7	13	including	include	VBG
cord-279932-bilr71ay	7	14	a	a	DT
cord-279932-bilr71ay	7	15	large	large	JJ
cord-279932-bilr71ay	7	16	safety	safety	NN
cord-279932-bilr71ay	7	17	and	and	CC
cord-279932-bilr71ay	7	18	efficacy	efficacy	NN
cord-279932-bilr71ay	7	19	trial	trial	NN
cord-279932-bilr71ay	7	20	in	in	IN
cord-279932-bilr71ay	7	21	which	which	WDT
cord-279932-bilr71ay	7	22	vaccinees	vaccinee	NNS
cord-279932-bilr71ay	7	23	are	be	VBP
cord-279932-bilr71ay	7	24	compared	compare	VBN
cord-279932-bilr71ay	7	25	to	to	IN
cord-279932-bilr71ay	7	26	placebo	placebo	NN
cord-279932-bilr71ay	7	27	recipients	recipient	NNS
cord-279932-bilr71ay	7	28	with	with	IN
cord-279932-bilr71ay	7	29	respect	respect	NN
cord-279932-bilr71ay	7	30	to	to	IN
cord-279932-bilr71ay	7	31	reactions	reaction	NNS
cord-279932-bilr71ay	7	32	and	and	CC
cord-279932-bilr71ay	7	33	to	to	IN
cord-279932-bilr71ay	7	34	the	the	DT
cord-279932-bilr71ay	7	35	incidence	incidence	NN
cord-279932-bilr71ay	7	36	of	of	IN
cord-279932-bilr71ay	7	37	the	the	DT
cord-279932-bilr71ay	7	38	disease	disease	NN
cord-279932-bilr71ay	7	39	for	for	IN
cord-279932-bilr71ay	7	40	which	which	WDT
cord-279932-bilr71ay	7	41	the	the	DT
cord-279932-bilr71ay	7	42	vaccine	vaccine	NN
cord-279932-bilr71ay	7	43	was	be	VBD
cord-279932-bilr71ay	7	44	developed	develop	VBN
cord-279932-bilr71ay	7	45	.	.	.
cord-279932-bilr71ay	8	1	In	in	IN
cord-279932-bilr71ay	8	2	this	this	DT
cord-279932-bilr71ay	8	3	pandemic	pandemic	NN
cord-279932-bilr71ay	8	4	,	,	,
cord-279932-bilr71ay	8	5	that	that	DT
cord-279932-bilr71ay	8	6	would	would	MD
cord-279932-bilr71ay	8	7	mean	mean	VB
cord-279932-bilr71ay	8	8	a	a	DT
cord-279932-bilr71ay	8	9	requirement	requirement	NN
cord-279932-bilr71ay	8	10	for	for	IN
cord-279932-bilr71ay	8	11	sufficient	sufficient	JJ
cord-279932-bilr71ay	8	12	COVID-19	COVID-19	NNP
cord-279932-bilr71ay	8	13	disease	disease	NN
cord-279932-bilr71ay	8	14	and	and	CC
cord-279932-bilr71ay	8	15	possibly	possibly	RB
cord-279932-bilr71ay	8	16	deaths	death	NNS
cord-279932-bilr71ay	8	17	in	in	IN
cord-279932-bilr71ay	8	18	the	the	DT
cord-279932-bilr71ay	8	19	placebo	placebo	NN
cord-279932-bilr71ay	8	20	group	group	NN
cord-279932-bilr71ay	8	21	,	,	,
cord-279932-bilr71ay	8	22	with	with	IN
cord-279932-bilr71ay	8	23	less	less	JJR
cord-279932-bilr71ay	8	24	disease	disease	NN
cord-279932-bilr71ay	8	25	in	in	IN
cord-279932-bilr71ay	8	26	the	the	DT
cord-279932-bilr71ay	8	27	vaccine	vaccine	NN
cord-279932-bilr71ay	8	28	group	group	NN
cord-279932-bilr71ay	8	29	.	.	.
cord-279932-bilr71ay	9	1	Meanwhile	meanwhile	RB
cord-279932-bilr71ay	9	2	,	,	,
cord-279932-bilr71ay	9	3	those	those	DT
cord-279932-bilr71ay	9	4	not	not	RB
cord-279932-bilr71ay	9	5	in	in	IN
cord-279932-bilr71ay	9	6	a	a	DT
cord-279932-bilr71ay	9	7	trial	trial	NN
cord-279932-bilr71ay	9	8	would	would	MD
cord-279932-bilr71ay	9	9	still	still	RB
cord-279932-bilr71ay	9	10	be	be	VB
cord-279932-bilr71ay	9	11	subject	subject	JJ
cord-279932-bilr71ay	9	12	to	to	IN
cord-279932-bilr71ay	9	13	the	the	DT
cord-279932-bilr71ay	9	14	ravages	ravage	NNS
cord-279932-bilr71ay	9	15	of	of	IN
cord-279932-bilr71ay	9	16	the	the	DT
cord-279932-bilr71ay	9	17	disease	disease	NN
cord-279932-bilr71ay	9	18	.	.	.
cord-279932-bilr71ay	10	1	Is	be	VBZ
cord-279932-bilr71ay	10	2	there	there	EX
cord-279932-bilr71ay	10	3	another	another	DT
cord-279932-bilr71ay	10	4	way	way	NN
cord-279932-bilr71ay	10	5	to	to	TO
cord-279932-bilr71ay	10	6	confirm	confirm	VB
cord-279932-bilr71ay	10	7	that	that	IN
cord-279932-bilr71ay	10	8	a	a	DT
cord-279932-bilr71ay	10	9	vaccine	vaccine	NN
cord-279932-bilr71ay	10	10	against	against	IN
cord-279932-bilr71ay	10	11	the	the	DT
cord-279932-bilr71ay	10	12	severe	severe	JJ
cord-279932-bilr71ay	10	13	acute	acute	JJ
cord-279932-bilr71ay	10	14	respiratory	respiratory	JJ
cord-279932-bilr71ay	10	15	syndrome	syndrome	NN
cord-279932-bilr71ay	10	16	coronavirus	coronavirus	NN
cord-279932-bilr71ay	10	17	2	2	CD
cord-279932-bilr71ay	11	1	(	(	-LRB-
cord-279932-bilr71ay	11	2	SARS	SARS	NNP
cord-279932-bilr71ay	11	3	-	-	HYPH
cord-279932-bilr71ay	11	4	CoV-2	CoV-2	NNP
cord-279932-bilr71ay	11	5	)	)	-RRB-
cord-279932-bilr71ay	11	6	is	be	VBZ
cord-279932-bilr71ay	11	7	protective	protective	JJ
cord-279932-bilr71ay	11	8	,	,	,
cord-279932-bilr71ay	11	9	and	and	CC
cord-279932-bilr71ay	11	10	thus	thus	RB
cord-279932-bilr71ay	11	11	to	to	TO
cord-279932-bilr71ay	11	12	accelerate	accelerate	VB
cord-279932-bilr71ay	11	13	its	-PRON-	PRP$
cord-279932-bilr71ay	11	14	use	use	NN
cord-279932-bilr71ay	11	15	?	?	.
cord-279932-bilr71ay	12	1	A	a	DT
cord-279932-bilr71ay	12	2	number	number	NN
cord-279932-bilr71ay	12	3	of	of	IN
cord-279932-bilr71ay	12	4	people	people	NNS
cord-279932-bilr71ay	12	5	,	,	,
cord-279932-bilr71ay	12	6	including	include	VBG
cord-279932-bilr71ay	12	7	Nguyen	Nguyen	NNP
cord-279932-bilr71ay	12	8	et	et	FW
cord-279932-bilr71ay	12	9	al	al	NNP
cord-279932-bilr71ay	12	10	[	[	-LRB-
cord-279932-bilr71ay	12	11	1	1	CD
cord-279932-bilr71ay	12	12	]	]	-RRB-
cord-279932-bilr71ay	12	13	in	in	IN
cord-279932-bilr71ay	12	14	this	this	DT
cord-279932-bilr71ay	12	15	issue	issue	NN
cord-279932-bilr71ay	12	16	and	and	CC
cord-279932-bilr71ay	12	17	others	other	NNS
cord-279932-bilr71ay	12	18	[	[	-LRB-
cord-279932-bilr71ay	12	19	2	2	CD
cord-279932-bilr71ay	12	20	]	]	-RRB-
cord-279932-bilr71ay	12	21	[	[	-LRB-
cord-279932-bilr71ay	12	22	3	3	CD
cord-279932-bilr71ay	12	23	]	]	-RRB-
cord-279932-bilr71ay	12	24	[	[	-LRB-
cord-279932-bilr71ay	12	25	4	4	CD
cord-279932-bilr71ay	12	26	]	]	-RRB-
cord-279932-bilr71ay	12	27	[	[	-LRB-
cord-279932-bilr71ay	12	28	5	5	CD
cord-279932-bilr71ay	12	29	]	]	-RRB-
cord-279932-bilr71ay	12	30	[	[	-LRB-
cord-279932-bilr71ay	12	31	6	6	CD
cord-279932-bilr71ay	12	32	]	]	-RRB-
cord-279932-bilr71ay	12	33	[	[	-LRB-
cord-279932-bilr71ay	12	34	7	7	CD
cord-279932-bilr71ay	12	35	]	]	-RRB-
cord-279932-bilr71ay	12	36	elsewhere	elsewhere	RB
cord-279932-bilr71ay	12	37	,	,	,
cord-279932-bilr71ay	12	38	have	have	VBP
cord-279932-bilr71ay	12	39	proposed	propose	VBN
cord-279932-bilr71ay	12	40	the	the	DT
cord-279932-bilr71ay	12	41	use	use	NN
cord-279932-bilr71ay	12	42	of	of	IN
cord-279932-bilr71ay	12	43	human	human	JJ
cord-279932-bilr71ay	12	44	challenge	challenge	NN
cord-279932-bilr71ay	12	45	trials	trial	NNS
cord-279932-bilr71ay	12	46	as	as	IN
cord-279932-bilr71ay	12	47	a	a	DT
cord-279932-bilr71ay	12	48	way	way	NN
cord-279932-bilr71ay	12	49	of	of	IN
cord-279932-bilr71ay	12	50	confirming	confirm	VBG
cord-279932-bilr71ay	12	51	the	the	DT
cord-279932-bilr71ay	12	52	protective	protective	JJ
cord-279932-bilr71ay	12	53	ability	ability	NN
cord-279932-bilr71ay	12	54	of	of	IN
cord-279932-bilr71ay	12	55	candidate	candidate	NN
cord-279932-bilr71ay	12	56	vaccines	vaccine	NNS
cord-279932-bilr71ay	12	57	,	,	,
cord-279932-bilr71ay	12	58	in	in	IN
cord-279932-bilr71ay	12	59	order	order	NN
cord-279932-bilr71ay	12	60	to	to	TO
cord-279932-bilr71ay	12	61	allow	allow	VB
cord-279932-bilr71ay	12	62	emergency	emergency	NN
cord-279932-bilr71ay	12	63	use	use	NN
cord-279932-bilr71ay	12	64	in	in	IN
cord-279932-bilr71ay	12	65	high	high	JJ
cord-279932-bilr71ay	12	66	-	-	HYPH
cord-279932-bilr71ay	12	67	risk	risk	NN
cord-279932-bilr71ay	12	68	groups	group	NNS
cord-279932-bilr71ay	12	69	and	and	CC
cord-279932-bilr71ay	12	70	to	to	TO
cord-279932-bilr71ay	12	71	facilitate	facilitate	VB
cord-279932-bilr71ay	12	72	the	the	DT
cord-279932-bilr71ay	12	73	way	way	NN
cord-279932-bilr71ay	12	74	to	to	IN
cord-279932-bilr71ay	12	75	eventual	eventual	JJ
cord-279932-bilr71ay	12	76	licensure	licensure	NN
cord-279932-bilr71ay	12	77	and	and	CC
cord-279932-bilr71ay	12	78	use	use	NN
cord-279932-bilr71ay	12	79	in	in	IN
cord-279932-bilr71ay	12	80	the	the	DT
cord-279932-bilr71ay	12	81	general	general	JJ
cord-279932-bilr71ay	12	82	population	population	NN
cord-279932-bilr71ay	12	83	.	.	.
cord-279932-bilr71ay	13	1	However	however	RB
cord-279932-bilr71ay	13	2	,	,	,
cord-279932-bilr71ay	13	3	there	there	EX
cord-279932-bilr71ay	13	4	are	be	VBP
cord-279932-bilr71ay	13	5	obvious	obvious	JJ
cord-279932-bilr71ay	13	6	objections	objection	NNS
cord-279932-bilr71ay	13	7	to	to	IN
cord-279932-bilr71ay	13	8	such	such	PDT
cord-279932-bilr71ay	13	9	a	a	DT
cord-279932-bilr71ay	13	10	strategy	strategy	NN
cord-279932-bilr71ay	13	11	,	,	,
cord-279932-bilr71ay	13	12	summarized	summarize	VBN
cord-279932-bilr71ay	13	13	by	by	IN
cord-279932-bilr71ay	13	14	the	the	DT
cord-279932-bilr71ay	13	15	adage	adage	NN
cord-279932-bilr71ay	13	16	that	that	WDT
cord-279932-bilr71ay	13	17	all	all	DT
cord-279932-bilr71ay	13	18	physicians	physician	NNS
cord-279932-bilr71ay	13	19	learn	learn	VBP
cord-279932-bilr71ay	13	20	:	:	:
cord-279932-bilr71ay	13	21	"	"	``
cord-279932-bilr71ay	13	22	above	above	IN
cord-279932-bilr71ay	13	23	all	all	DT
cord-279932-bilr71ay	13	24	,	,	,
cord-279932-bilr71ay	13	25	do	do	VBP
cord-279932-bilr71ay	13	26	no	no	DT
cord-279932-bilr71ay	13	27	harm	harm	NN
cord-279932-bilr71ay	13	28	.	.	.
cord-279932-bilr71ay	14	1	"	"	``
cord-279932-bilr71ay	14	2	It	-PRON-	PRP
cord-279932-bilr71ay	14	3	is	be	VBZ
cord-279932-bilr71ay	14	4	repugnant	repugnant	JJ
cord-279932-bilr71ay	14	5	to	to	TO
cord-279932-bilr71ay	14	6	think	think	VB
cord-279932-bilr71ay	14	7	that	that	IN
cord-279932-bilr71ay	14	8	something	something	NN
cord-279932-bilr71ay	14	9	we	-PRON-	PRP
cord-279932-bilr71ay	14	10	do	do	VBP
cord-279932-bilr71ay	14	11	may	may	MD
cord-279932-bilr71ay	14	12	cause	cause	VB
cord-279932-bilr71ay	14	13	disease	disease	NN
cord-279932-bilr71ay	14	14	and	and	CC
cord-279932-bilr71ay	14	15	perhaps	perhaps	RB
cord-279932-bilr71ay	14	16	death	death	NN
cord-279932-bilr71ay	14	17	,	,	,
cord-279932-bilr71ay	14	18	even	even	RB
cord-279932-bilr71ay	14	19	if	if	IN
cord-279932-bilr71ay	14	20	the	the	DT
cord-279932-bilr71ay	14	21	goal	goal	NN
cord-279932-bilr71ay	14	22	in	in	IN
cord-279932-bilr71ay	14	23	the	the	DT
cord-279932-bilr71ay	14	24	long	long	JJ
cord-279932-bilr71ay	14	25	term	term	NN
cord-279932-bilr71ay	14	26	is	be	VBZ
cord-279932-bilr71ay	14	27	to	to	TO
cord-279932-bilr71ay	14	28	save	save	VB
cord-279932-bilr71ay	14	29	lives	life	NNS
cord-279932-bilr71ay	14	30	.	.	.
cord-279932-bilr71ay	15	1	The	the	DT
cord-279932-bilr71ay	15	2	idea	idea	NN
cord-279932-bilr71ay	15	3	behind	behind	IN
cord-279932-bilr71ay	15	4	human	human	JJ
cord-279932-bilr71ay	15	5	challenge	challenge	NN
cord-279932-bilr71ay	15	6	trials	trial	NNS
cord-279932-bilr71ay	15	7	is	be	VBZ
cord-279932-bilr71ay	15	8	to	to	TO
cord-279932-bilr71ay	15	9	recruit	recruit	VB
cord-279932-bilr71ay	15	10	young	young	JJ
cord-279932-bilr71ay	15	11	,	,	,
cord-279932-bilr71ay	15	12	healthy	healthy	JJ
cord-279932-bilr71ay	15	13	volunteers	volunteer	NNS
cord-279932-bilr71ay	15	14	who	who	WP
cord-279932-bilr71ay	15	15	have	have	VBP
cord-279932-bilr71ay	15	16	the	the	DT
cord-279932-bilr71ay	15	17	lowest	low	JJS
cord-279932-bilr71ay	15	18	chance	chance	NN
cord-279932-bilr71ay	15	19	of	of	IN
cord-279932-bilr71ay	15	20	serious	serious	JJ
cord-279932-bilr71ay	15	21	disease	disease	NN
cord-279932-bilr71ay	15	22	,	,	,
cord-279932-bilr71ay	15	23	who	who	WP
cord-279932-bilr71ay	15	24	would	would	MD
cord-279932-bilr71ay	15	25	be	be	VB
cord-279932-bilr71ay	15	26	given	give	VBN
cord-279932-bilr71ay	15	27	vaccine	vaccine	NN
cord-279932-bilr71ay	15	28	candidates	candidate	NNS
cord-279932-bilr71ay	15	29	and	and	CC
cord-279932-bilr71ay	15	30	then	then	RB
cord-279932-bilr71ay	15	31	be	be	VB
cord-279932-bilr71ay	15	32	challenged	challenge	VBN
cord-279932-bilr71ay	15	33	with	with	IN
cord-279932-bilr71ay	15	34	SARS	SARS	NNP
cord-279932-bilr71ay	15	35	-	-	HYPH
cord-279932-bilr71ay	15	36	CoV-2	CoV-2	NNP
cord-279932-bilr71ay	15	37	in	in	IN
cord-279932-bilr71ay	15	38	order	order	NN
cord-279932-bilr71ay	15	39	to	to	TO
cord-279932-bilr71ay	15	40	determine	determine	VB
cord-279932-bilr71ay	15	41	whether	whether	IN
cord-279932-bilr71ay	15	42	the	the	DT
cord-279932-bilr71ay	15	43	vaccines	vaccine	NNS
cord-279932-bilr71ay	15	44	protect	protect	VBP
cord-279932-bilr71ay	15	45	.	.	.
cord-279932-bilr71ay	16	1	However	however	RB
cord-279932-bilr71ay	16	2	,	,	,
cord-279932-bilr71ay	16	3	there	there	EX
cord-279932-bilr71ay	16	4	would	would	MD
cord-279932-bilr71ay	16	5	also	also	RB
cord-279932-bilr71ay	16	6	have	have	VB
cord-279932-bilr71ay	16	7	to	to	TO
cord-279932-bilr71ay	16	8	be	be	VB
cord-279932-bilr71ay	16	9	prior	prior	JJ
cord-279932-bilr71ay	16	10	challenges	challenge	NNS
cord-279932-bilr71ay	16	11	of	of	IN
cord-279932-bilr71ay	16	12	unvaccinated	unvaccinated	JJ
cord-279932-bilr71ay	16	13	volunteers	volunteer	NNS
cord-279932-bilr71ay	16	14	to	to	TO
cord-279932-bilr71ay	16	15	determine	determine	VB
cord-279932-bilr71ay	16	16	the	the	DT
cord-279932-bilr71ay	16	17	optimal	optimal	JJ
cord-279932-bilr71ay	16	18	infectious	infectious	JJ
cord-279932-bilr71ay	16	19	dose	dose	NN
cord-279932-bilr71ay	16	20	,	,	,
cord-279932-bilr71ay	16	21	and	and	CC
cord-279932-bilr71ay	16	22	also	also	RB
cord-279932-bilr71ay	16	23	challenges	challenge	NNS
cord-279932-bilr71ay	16	24	of	of	IN
cord-279932-bilr71ay	16	25	some	some	DT
cord-279932-bilr71ay	16	26	volunteers	volunteer	NNS
cord-279932-bilr71ay	16	27	who	who	WP
cord-279932-bilr71ay	16	28	have	have	VBP
cord-279932-bilr71ay	16	29	had	have	VBN
cord-279932-bilr71ay	16	30	prior	prior	JJ
cord-279932-bilr71ay	16	31	COVID-19	covid-19	CD
cord-279932-bilr71ay	16	32	infections	infection	NNS
cord-279932-bilr71ay	16	33	,	,	,
cord-279932-bilr71ay	16	34	to	to	TO
cord-279932-bilr71ay	16	35	confirm	confirm	VB
cord-279932-bilr71ay	16	36	that	that	IN
cord-279932-bilr71ay	16	37	immune	immune	JJ
cord-279932-bilr71ay	16	38	responses	response	NNS
cord-279932-bilr71ay	16	39	can	can	MD
cord-279932-bilr71ay	16	40	give	give	VB
cord-279932-bilr71ay	16	41	subsequent	subsequent	JJ
cord-279932-bilr71ay	16	42	protection	protection	NN
cord-279932-bilr71ay	16	43	.	.	.
cord-279932-bilr71ay	17	1	Obviously	obviously	RB
cord-279932-bilr71ay	17	2	,	,	,
cord-279932-bilr71ay	17	3	the	the	DT
cord-279932-bilr71ay	17	4	ethical	ethical	JJ
cord-279932-bilr71ay	17	5	issues	issue	NNS
cord-279932-bilr71ay	17	6	around	around	IN
cord-279932-bilr71ay	17	7	human	human	JJ
cord-279932-bilr71ay	17	8	challenge	challenge	NN
cord-279932-bilr71ay	17	9	trials	trial	NNS
cord-279932-bilr71ay	17	10	are	be	VBP
cord-279932-bilr71ay	17	11	many	many	JJ
cord-279932-bilr71ay	17	12	.	.	.
cord-279932-bilr71ay	18	1	However	however	RB
cord-279932-bilr71ay	18	2	,	,	,
cord-279932-bilr71ay	18	3	numerous	numerous	JJ
cord-279932-bilr71ay	18	4	ethicists	ethicist	NNS
cord-279932-bilr71ay	18	5	have	have	VBP
cord-279932-bilr71ay	18	6	weighed	weigh	VBN
cord-279932-bilr71ay	18	7	in	in	RP
cord-279932-bilr71ay	18	8	on	on	IN
cord-279932-bilr71ay	18	9	this	this	DT
cord-279932-bilr71ay	18	10	issue	issue	NN
cord-279932-bilr71ay	18	11	.	.	.
cord-279932-bilr71ay	19	1	Although	although	IN
cord-279932-bilr71ay	19	2	some	some	DT
cord-279932-bilr71ay	19	3	have	have	VBP
cord-279932-bilr71ay	19	4	disagreed	disagree	VBN
cord-279932-bilr71ay	19	5	[	[	-LRB-
cord-279932-bilr71ay	19	6	8	8	CD
cord-279932-bilr71ay	19	7	,	,	,
cord-279932-bilr71ay	19	8	9	9	CD
cord-279932-bilr71ay	19	9	]	]	-RRB-
cord-279932-bilr71ay	19	10	,	,	,
cord-279932-bilr71ay	19	11	the	the	DT
cord-279932-bilr71ay	19	12	majority	majority	NN
cord-279932-bilr71ay	19	13	have	have	VBP
cord-279932-bilr71ay	19	14	accepted	accept	VBN
cord-279932-bilr71ay	19	15	human	human	JJ
cord-279932-bilr71ay	19	16	challenge	challenge	NN
cord-279932-bilr71ay	19	17	trials	trial	NNS
cord-279932-bilr71ay	19	18	done	do	VBN
cord-279932-bilr71ay	19	19	in	in	IN
cord-279932-bilr71ay	19	20	informed	informed	JJ
cord-279932-bilr71ay	19	21	volunteers	volunteer	NNS
cord-279932-bilr71ay	19	22	as	as	IN
cord-279932-bilr71ay	19	23	ethical	ethical	JJ
cord-279932-bilr71ay	19	24	under	under	IN
cord-279932-bilr71ay	19	25	the	the	DT
cord-279932-bilr71ay	19	26	current	current	JJ
cord-279932-bilr71ay	19	27	circumstances	circumstance	NNS
cord-279932-bilr71ay	19	28	.	.	.
cord-279932-bilr71ay	20	1	Some	some	DT
cord-279932-bilr71ay	20	2	ethicists	ethicist	NNS
cord-279932-bilr71ay	20	3	have	have	VBP
cord-279932-bilr71ay	20	4	pointed	point	VBN
cord-279932-bilr71ay	20	5	out	out	RP
cord-279932-bilr71ay	20	6	that	that	IN
cord-279932-bilr71ay	20	7	organ	organ	NN
cord-279932-bilr71ay	20	8	donation	donation	NN
cord-279932-bilr71ay	20	9	by	by	IN
cord-279932-bilr71ay	20	10	volunteers	volunteer	NNS
cord-279932-bilr71ay	20	11	is	be	VBZ
cord-279932-bilr71ay	20	12	an	an	DT
cord-279932-bilr71ay	20	13	accepted	accepted	JJ
cord-279932-bilr71ay	20	14	practice	practice	NN
cord-279932-bilr71ay	20	15	,	,	,
cord-279932-bilr71ay	20	16	despite	despite	IN
cord-279932-bilr71ay	20	17	a	a	DT
cord-279932-bilr71ay	20	18	low	low	JJ
cord-279932-bilr71ay	20	19	but	but	CC
cord-279932-bilr71ay	20	20	definite	definite	JJ
cord-279932-bilr71ay	20	21	risk	risk	NN
cord-279932-bilr71ay	20	22	of	of	IN
cord-279932-bilr71ay	20	23	death	death	NN
cord-279932-bilr71ay	20	24	or	or	CC
cord-279932-bilr71ay	20	25	disability	disability	NN
cord-279932-bilr71ay	20	26	,	,	,
cord-279932-bilr71ay	20	27	which	which	WDT
cord-279932-bilr71ay	20	28	is	be	VBZ
cord-279932-bilr71ay	20	29	equivalent	equivalent	JJ
cord-279932-bilr71ay	20	30	to	to	IN
cord-279932-bilr71ay	20	31	the	the	DT
cord-279932-bilr71ay	20	32	risk	risk	NN
cord-279932-bilr71ay	20	33	of	of	IN
cord-279932-bilr71ay	20	34	COVID-19	COVID-19	NNP
cord-279932-bilr71ay	20	35	in	in	IN
cord-279932-bilr71ay	20	36	the	the	DT
cord-279932-bilr71ay	20	37	young	young	JJ
cord-279932-bilr71ay	20	38	age	age	NN
cord-279932-bilr71ay	20	39	group	group	NN
cord-279932-bilr71ay	20	40	of	of	IN
cord-279932-bilr71ay	20	41	volunteers	volunteer	NNS
cord-279932-bilr71ay	20	42	[	[	-LRB-
cord-279932-bilr71ay	20	43	10	10	CD
cord-279932-bilr71ay	20	44	]	]	-RRB-
cord-279932-bilr71ay	20	45	.	.	.
cord-279932-bilr71ay	21	1	The	the	DT
cord-279932-bilr71ay	21	2	organization	organization	NN
cord-279932-bilr71ay	21	3	to	to	TO
cord-279932-bilr71ay	21	4	which	which	WDT
cord-279932-bilr71ay	21	5	the	the	DT
cord-279932-bilr71ay	21	6	authors	author	NNS
cord-279932-bilr71ay	21	7	of	of	IN
cord-279932-bilr71ay	21	8	the	the	DT
cord-279932-bilr71ay	21	9	paper	paper	NN
cord-279932-bilr71ay	21	10	by	by	IN
cord-279932-bilr71ay	21	11	Nguyen	Nguyen	NNP
cord-279932-bilr71ay	21	12	et	et	NNP
cord-279932-bilr71ay	21	13	al	al	NNP
cord-279932-bilr71ay	21	14	[	[	-LRB-
cord-279932-bilr71ay	21	15	1	1	CD
cord-279932-bilr71ay	21	16	]	]	-RRB-
cord-279932-bilr71ay	21	17	belong	belong	VBP
cord-279932-bilr71ay	21	18	,	,	,
cord-279932-bilr71ay	21	19	One	one	CD
cord-279932-bilr71ay	21	20	Day	Day	NNP
cord-279932-bilr71ay	21	21	Sooner	Sooner	NNP
cord-279932-bilr71ay	21	22	,	,	,
cord-279932-bilr71ay	21	23	represents	represent	VBZ
cord-279932-bilr71ay	21	24	literally	literally	RB
cord-279932-bilr71ay	21	25	thousands	thousand	NNS
cord-279932-bilr71ay	21	26	of	of	IN
cord-279932-bilr71ay	21	27	volunteers	volunteer	NNS
cord-279932-bilr71ay	21	28	for	for	IN
cord-279932-bilr71ay	21	29	SARS	SARS	NNP
cord-279932-bilr71ay	21	30	-	-	HYPH
cord-279932-bilr71ay	21	31	CoV-2	CoV-2	NNP
cord-279932-bilr71ay	21	32	challenges	challenge	NNS
cord-279932-bilr71ay	21	33	.	.	.
cord-279932-bilr71ay	22	1	Aside	aside	RB
cord-279932-bilr71ay	22	2	from	from	IN
cord-279932-bilr71ay	22	3	the	the	DT
cord-279932-bilr71ay	22	4	ethical	ethical	JJ
cord-279932-bilr71ay	22	5	issues	issue	NNS
cord-279932-bilr71ay	22	6	,	,	,
cord-279932-bilr71ay	22	7	the	the	DT
cord-279932-bilr71ay	22	8	principal	principal	JJ
cord-279932-bilr71ay	22	9	objection	objection	NN
cord-279932-bilr71ay	22	10	to	to	IN
cord-279932-bilr71ay	22	11	human	human	JJ
cord-279932-bilr71ay	22	12	challenge	challenge	NN
cord-279932-bilr71ay	22	13	trials	trial	NNS
cord-279932-bilr71ay	22	14	with	with	IN
cord-279932-bilr71ay	22	15	SARS	SARS	NNP
cord-279932-bilr71ay	22	16	-	-	HYPH
cord-279932-bilr71ay	22	17	CoV-2	CoV-2	NNP
cord-279932-bilr71ay	22	18	is	be	VBZ
cord-279932-bilr71ay	22	19	the	the	DT
cord-279932-bilr71ay	22	20	absence	absence	NN
cord-279932-bilr71ay	22	21	of	of	IN
cord-279932-bilr71ay	22	22	a	a	DT
cord-279932-bilr71ay	22	23	reliable	reliable	JJ
cord-279932-bilr71ay	22	24	rescue	rescue	NN
cord-279932-bilr71ay	22	25	medication	medication	NN
cord-279932-bilr71ay	22	26	for	for	IN
cord-279932-bilr71ay	22	27	the	the	DT
cord-279932-bilr71ay	22	28	treatment	treatment	NN
cord-279932-bilr71ay	22	29	of	of	IN
cord-279932-bilr71ay	22	30	serious	serious	JJ
cord-279932-bilr71ay	22	31	disease	disease	NN
cord-279932-bilr71ay	22	32	.	.	.
cord-279932-bilr71ay	23	1	To	to	TO
cord-279932-bilr71ay	23	2	mitigate	mitigate	VB
cord-279932-bilr71ay	23	3	disease	disease	NN
cord-279932-bilr71ay	23	4	severity	severity	NN
cord-279932-bilr71ay	23	5	,	,	,
cord-279932-bilr71ay	23	6	one	one	PRP
cord-279932-bilr71ay	23	7	could	could	MD
cord-279932-bilr71ay	23	8	begin	begin	VB
cord-279932-bilr71ay	23	9	treatment	treatment	NN
cord-279932-bilr71ay	23	10	with	with	IN
cord-279932-bilr71ay	23	11	Remdesivir	Remdesivir	NNP
cord-279932-bilr71ay	23	12	,	,	,
cord-279932-bilr71ay	23	13	convalescent	convalescent	JJ
cord-279932-bilr71ay	23	14	serum	serum	NN
cord-279932-bilr71ay	23	15	,	,	,
cord-279932-bilr71ay	23	16	and	and	CC
cord-279932-bilr71ay	23	17	steroids	steroid	NNS
cord-279932-bilr71ay	23	18	as	as	RB
cord-279932-bilr71ay	23	19	soon	soon	RB
cord-279932-bilr71ay	23	20	as	as	IN
cord-279932-bilr71ay	23	21	a	a	DT
cord-279932-bilr71ay	23	22	lower	low	JJR
cord-279932-bilr71ay	23	23	respiratory	respiratory	JJ
cord-279932-bilr71ay	23	24	tract	tract	NN
cord-279932-bilr71ay	23	25	infection	infection	NN
cord-279932-bilr71ay	23	26	is	be	VBZ
cord-279932-bilr71ay	23	27	confirmed	confirm	VBN
cord-279932-bilr71ay	23	28	,	,	,
cord-279932-bilr71ay	23	29	but	but	CC
cord-279932-bilr71ay	23	30	one	one	PRP
cord-279932-bilr71ay	23	31	must	must	MD
cord-279932-bilr71ay	23	32	bear	bear	VB
cord-279932-bilr71ay	23	33	in	in	IN
cord-279932-bilr71ay	23	34	mind	mind	NN
cord-279932-bilr71ay	23	35	that	that	IN
cord-279932-bilr71ay	23	36	as	as	IN
cord-279932-bilr71ay	23	37	of	of	IN
cord-279932-bilr71ay	23	38	this	this	DT
cord-279932-bilr71ay	23	39	writing	writing	NN
cord-279932-bilr71ay	23	40	,	,	,
cord-279932-bilr71ay	23	41	no	no	DT
cord-279932-bilr71ay	23	42	therapy	therapy	NN
cord-279932-bilr71ay	23	43	is	be	VBZ
cord-279932-bilr71ay	23	44	confirmed	confirm	VBN
cord-279932-bilr71ay	23	45	to	to	TO
cord-279932-bilr71ay	23	46	be	be	VB
cord-279932-bilr71ay	23	47	completely	completely	RB
cord-279932-bilr71ay	23	48	effective	effective	JJ
cord-279932-bilr71ay	23	49	.	.	.
cord-279932-bilr71ay	24	1	Nevertheless	nevertheless	RB
cord-279932-bilr71ay	24	2	,	,	,
cord-279932-bilr71ay	24	3	by	by	IN
cord-279932-bilr71ay	24	4	confining	confine	VBG
cord-279932-bilr71ay	24	5	studies	study	NNS
cord-279932-bilr71ay	24	6	to	to	IN
cord-279932-bilr71ay	24	7	young	young	JJ
cord-279932-bilr71ay	24	8	(	(	-LRB-
cord-279932-bilr71ay	24	9	18	18	CD
cord-279932-bilr71ay	24	10	-	-	SYM
cord-279932-bilr71ay	24	11	25	25	CD
cord-279932-bilr71ay	24	12	years	year	NNS
cord-279932-bilr71ay	24	13	old	old	JJ
cord-279932-bilr71ay	24	14	)	)	-RRB-
cord-279932-bilr71ay	24	15	and	and	CC
cord-279932-bilr71ay	24	16	healthy	healthy	JJ
cord-279932-bilr71ay	24	17	volunteers	volunteer	NNS
cord-279932-bilr71ay	24	18	,	,	,
cord-279932-bilr71ay	24	19	current	current	JJ
cord-279932-bilr71ay	24	20	data	datum	NNS
cord-279932-bilr71ay	24	21	suggest	suggest	VBP
cord-279932-bilr71ay	24	22	a	a	DT
cord-279932-bilr71ay	24	23	very	very	RB
cord-279932-bilr71ay	24	24	low	low	JJ
cord-279932-bilr71ay	24	25	risk	risk	NN
cord-279932-bilr71ay	24	26	of	of	IN
cord-279932-bilr71ay	24	27	severe	severe	JJ
cord-279932-bilr71ay	24	28	disease	disease	NN
cord-279932-bilr71ay	24	29	.	.	.
cord-279932-bilr71ay	25	1	In	in	IN
cord-279932-bilr71ay	25	2	evaluating	evaluate	VBG
cord-279932-bilr71ay	25	3	the	the	DT
cord-279932-bilr71ay	25	4	idea	idea	NN
cord-279932-bilr71ay	25	5	of	of	IN
cord-279932-bilr71ay	25	6	human	human	JJ
cord-279932-bilr71ay	25	7	challenges	challenge	NNS
cord-279932-bilr71ay	25	8	with	with	IN
cord-279932-bilr71ay	25	9	SARS	SARS	NNP
cord-279932-bilr71ay	25	10	-	-	HYPH
cord-279932-bilr71ay	25	11	CoV-2	CoV-2	NNP
cord-279932-bilr71ay	25	12	,	,	,
cord-279932-bilr71ay	25	13	one	one	PRP
cord-279932-bilr71ay	25	14	must	must	MD
cord-279932-bilr71ay	25	15	balance	balance	VB
cord-279932-bilr71ay	25	16	the	the	DT
cord-279932-bilr71ay	25	17	risks	risk	NNS
cord-279932-bilr71ay	25	18	of	of	IN
cord-279932-bilr71ay	25	19	those	those	DT
cord-279932-bilr71ay	25	20	challenges	challenge	NNS
cord-279932-bilr71ay	25	21	against	against	IN
cord-279932-bilr71ay	25	22	the	the	DT
cord-279932-bilr71ay	25	23	risks	risk	NNS
cord-279932-bilr71ay	25	24	associated	associate	VBN
cord-279932-bilr71ay	25	25	with	with	IN
cord-279932-bilr71ay	25	26	the	the	DT
cord-279932-bilr71ay	25	27	usual	usual	JJ
cord-279932-bilr71ay	25	28	process	process	NN
cord-279932-bilr71ay	25	29	of	of	IN
cord-279932-bilr71ay	25	30	vaccine	vaccine	NN
cord-279932-bilr71ay	25	31	development	development	NN
cord-279932-bilr71ay	25	32	and	and	CC
cord-279932-bilr71ay	25	33	evaluation	evaluation	NN
cord-279932-bilr71ay	25	34	.	.	.
cord-279932-bilr71ay	26	1	Table	table	NN
cord-279932-bilr71ay	26	2	1	1	CD
cord-279932-bilr71ay	26	3	attempts	attempt	NNS
cord-279932-bilr71ay	26	4	to	to	TO
cord-279932-bilr71ay	26	5	contrast	contrast	VB
cord-279932-bilr71ay	26	6	the	the	DT
cord-279932-bilr71ay	26	7	advantages	advantage	NNS
cord-279932-bilr71ay	26	8	and	and	CC
cord-279932-bilr71ay	26	9	disadvantages	disadvantage	NNS
cord-279932-bilr71ay	26	10	of	of	IN
cord-279932-bilr71ay	26	11	each	each	DT
cord-279932-bilr71ay	26	12	approach	approach	NN
cord-279932-bilr71ay	26	13	.	.	.
cord-279932-bilr71ay	27	1	Clearly	clearly	RB
cord-279932-bilr71ay	27	2	,	,	,
cord-279932-bilr71ay	27	3	there	there	EX
cord-279932-bilr71ay	27	4	are	be	VBP
cord-279932-bilr71ay	27	5	unknowns	unknown	NNS
cord-279932-bilr71ay	27	6	that	that	WDT
cord-279932-bilr71ay	27	7	should	should	MD
cord-279932-bilr71ay	27	8	obviate	obviate	VB
cord-279932-bilr71ay	27	9	dogmatism	dogmatism	NN
cord-279932-bilr71ay	27	10	,	,	,
cord-279932-bilr71ay	27	11	but	but	CC
cord-279932-bilr71ay	27	12	it	-PRON-	PRP
cord-279932-bilr71ay	27	13	appears	appear	VBZ
cord-279932-bilr71ay	27	14	to	to	IN
cord-279932-bilr71ay	27	15	this	this	DT
cord-279932-bilr71ay	27	16	observer	observer	NN
cord-279932-bilr71ay	27	17	that	that	IN
cord-279932-bilr71ay	27	18	human	human	JJ
cord-279932-bilr71ay	27	19	challenge	challenge	NN
cord-279932-bilr71ay	27	20	experiments	experiment	NNS
cord-279932-bilr71ay	27	21	are	be	VBP
cord-279932-bilr71ay	27	22	worth	worth	JJ
cord-279932-bilr71ay	27	23	preparing	prepare	VBG
cord-279932-bilr71ay	27	24	for	for	IN
cord-279932-bilr71ay	27	25	and	and	CC
cord-279932-bilr71ay	27	26	potentially	potentially	RB
cord-279932-bilr71ay	27	27	putting	put	VBG
cord-279932-bilr71ay	27	28	in	in	RP
cord-279932-bilr71ay	27	29	motion	motion	NN
cord-279932-bilr71ay	27	30	,	,	,
cord-279932-bilr71ay	27	31	particularly	particularly	RB
cord-279932-bilr71ay	27	32	considering	consider	VBG
cord-279932-bilr71ay	27	33	the	the	DT
cord-279932-bilr71ay	27	34	large	large	JJ
cord-279932-bilr71ay	27	35	number	number	NN
cord-279932-bilr71ay	27	36	of	of	IN
cord-279932-bilr71ay	27	37	current	current	JJ
cord-279932-bilr71ay	27	38	vaccine	vaccine	NN
cord-279932-bilr71ay	27	39	candidates	candidate	NNS
cord-279932-bilr71ay	27	40	and	and	CC
cord-279932-bilr71ay	27	41	the	the	DT
cord-279932-bilr71ay	27	42	difficulties	difficulty	NNS
cord-279932-bilr71ay	27	43	of	of	IN
cord-279932-bilr71ay	27	44	conducting	conduct	VBG
cord-279932-bilr71ay	27	45	Phase	phase	NN
cord-279932-bilr71ay	27	46	3	3	CD
cord-279932-bilr71ay	27	47	trials	trial	NNS
cord-279932-bilr71ay	27	48	for	for	IN
cord-279932-bilr71ay	27	49	all	all	DT
cord-279932-bilr71ay	27	50	of	of	IN
cord-279932-bilr71ay	27	51	them	-PRON-	PRP
cord-279932-bilr71ay	27	52	.	.	.
cord-279932-bilr71ay	28	1	Clearly	clearly	RB
cord-279932-bilr71ay	28	2	,	,	,
cord-279932-bilr71ay	28	3	human	human	JJ
cord-279932-bilr71ay	28	4	challenges	challenge	NNS
cord-279932-bilr71ay	28	5	in	in	IN
cord-279932-bilr71ay	28	6	a	a	DT
cord-279932-bilr71ay	28	7	pandemic	pandemic	NN
cord-279932-bilr71ay	28	8	disease	disease	NN
cord-279932-bilr71ay	28	9	with	with	IN
cord-279932-bilr71ay	28	10	associated	associate	VBN
cord-279932-bilr71ay	28	11	fatality	fatality	NN
cord-279932-bilr71ay	28	12	,	,	,
cord-279932-bilr71ay	28	13	such	such	JJ
cord-279932-bilr71ay	28	14	as	as	IN
cord-279932-bilr71ay	28	15	COVID-19	COVID-19	NNP
cord-279932-bilr71ay	28	16	,	,	,
cord-279932-bilr71ay	28	17	must	must	MD
cord-279932-bilr71ay	28	18	be	be	VB
cord-279932-bilr71ay	28	19	seriously	seriously	RB
cord-279932-bilr71ay	28	20	evaluated	evaluate	VBN
cord-279932-bilr71ay	28	21	before	before	IN
cord-279932-bilr71ay	28	22	launching	launch	VBG
cord-279932-bilr71ay	28	23	them	-PRON-	PRP
cord-279932-bilr71ay	28	24	.	.	.
cord-279932-bilr71ay	29	1	The	the	DT
cord-279932-bilr71ay	29	2	manufacture	manufacture	NN
cord-279932-bilr71ay	29	3	of	of	IN
cord-279932-bilr71ay	29	4	a	a	DT
cord-279932-bilr71ay	29	5	challenge	challenge	NN
cord-279932-bilr71ay	29	6	virus	virus	NN
cord-279932-bilr71ay	29	7	will	will	MD
cord-279932-bilr71ay	29	8	take	take	VB
cord-279932-bilr71ay	29	9	some	some	DT
cord-279932-bilr71ay	29	10	weeks	week	NNS
cord-279932-bilr71ay	29	11	,	,	,
cord-279932-bilr71ay	29	12	as	as	IN
cord-279932-bilr71ay	29	13	will	will	MD
cord-279932-bilr71ay	29	14	organizing	organize	VBG
cord-279932-bilr71ay	29	15	a	a	DT
cord-279932-bilr71ay	29	16	site	site	NN
cord-279932-bilr71ay	29	17	in	in	IN
cord-279932-bilr71ay	29	18	which	which	WDT
cord-279932-bilr71ay	29	19	the	the	DT
cord-279932-bilr71ay	29	20	challenged	challenge	VBN
cord-279932-bilr71ay	29	21	volunteers	volunteer	NNS
cord-279932-bilr71ay	29	22	can	can	MD
cord-279932-bilr71ay	29	23	be	be	VB
cord-279932-bilr71ay	29	24	isolated	isolate	VBN
cord-279932-bilr71ay	29	25	and	and	CC
cord-279932-bilr71ay	29	26	receive	receive	VB
cord-279932-bilr71ay	29	27	medical	medical	JJ
cord-279932-bilr71ay	29	28	care	care	NN
cord-279932-bilr71ay	29	29	.	.	.
cord-279932-bilr71ay	30	1	However	however	RB
cord-279932-bilr71ay	30	2	,	,	,
cord-279932-bilr71ay	30	3	the	the	DT
cord-279932-bilr71ay	30	4	objection	objection	NN
cord-279932-bilr71ay	30	5	of	of	IN
cord-279932-bilr71ay	30	6	some	some	DT
cord-279932-bilr71ay	30	7	that	that	IN
cord-279932-bilr71ay	30	8	those	those	DT
cord-279932-bilr71ay	30	9	steps	step	NNS
cord-279932-bilr71ay	30	10	will	will	MD
cord-279932-bilr71ay	30	11	take	take	VB
cord-279932-bilr71ay	30	12	so	so	RB
cord-279932-bilr71ay	30	13	long	long	RB
cord-279932-bilr71ay	30	14	that	that	IN
cord-279932-bilr71ay	30	15	the	the	DT
cord-279932-bilr71ay	30	16	value	value	NN
cord-279932-bilr71ay	30	17	of	of	IN
cord-279932-bilr71ay	30	18	human	human	JJ
cord-279932-bilr71ay	30	19	challenge	challenge	NN
cord-279932-bilr71ay	30	20	studies	study	NNS
cord-279932-bilr71ay	30	21	will	will	MD
cord-279932-bilr71ay	30	22	be	be	VB
cord-279932-bilr71ay	30	23	negated	negate	VBN
cord-279932-bilr71ay	30	24	is	be	VBZ
cord-279932-bilr71ay	30	25	a	a	DT
cord-279932-bilr71ay	30	26	self	self	NN
cord-279932-bilr71ay	30	27	-	-	HYPH
cord-279932-bilr71ay	30	28	fulfilling	fulfil	VBG
cord-279932-bilr71ay	30	29	prophecy	prophecy	NN
cord-279932-bilr71ay	30	30	:	:	:
cord-279932-bilr71ay	30	31	the	the	DT
cord-279932-bilr71ay	30	32	longer	long	RBR
cord-279932-bilr71ay	30	33	we	-PRON-	PRP
cord-279932-bilr71ay	30	34	argue	argue	VBP
cord-279932-bilr71ay	30	35	,	,	,
cord-279932-bilr71ay	30	36	the	the	DT
cord-279932-bilr71ay	30	37	less	less	RBR
cord-279932-bilr71ay	30	38	the	the	DT
cord-279932-bilr71ay	30	39	value	value	NN
cord-279932-bilr71ay	30	40	of	of	IN
cord-279932-bilr71ay	30	41	the	the	DT
cord-279932-bilr71ay	30	42	proposed	propose	VBN
cord-279932-bilr71ay	30	43	idea	idea	NN
cord-279932-bilr71ay	30	44	.	.	.
cord-279932-bilr71ay	31	1	If	if	IN
cord-279932-bilr71ay	31	2	vaccines	vaccine	NNS
cord-279932-bilr71ay	31	3	are	be	VBP
cord-279932-bilr71ay	31	4	rapidly	rapidly	RB
cord-279932-bilr71ay	31	5	tested	test	VBN
cord-279932-bilr71ay	31	6	and	and	CC
cord-279932-bilr71ay	31	7	made	make	VBN
cord-279932-bilr71ay	31	8	available	available	JJ
cord-279932-bilr71ay	31	9	through	through	IN
cord-279932-bilr71ay	31	10	the	the	DT
cord-279932-bilr71ay	31	11	usual	usual	JJ
cord-279932-bilr71ay	31	12	Phases	Phases	NNP
cord-279932-bilr71ay	31	13	1	1	CD
cord-279932-bilr71ay	31	14	-	-	SYM
cord-279932-bilr71ay	31	15	3	3	CD
cord-279932-bilr71ay	31	16	,	,	,
cord-279932-bilr71ay	31	17	human	human	JJ
cord-279932-bilr71ay	31	18	challenge	challenge	NN
cord-279932-bilr71ay	31	19	trials	trial	NNS
cord-279932-bilr71ay	31	20	might	may	MD
cord-279932-bilr71ay	31	21	be	be	VB
cord-279932-bilr71ay	31	22	obviated	obviate	VBN
cord-279932-bilr71ay	31	23	and	and	CC
cord-279932-bilr71ay	31	24	could	could	MD
cord-279932-bilr71ay	31	25	always	always	RB
cord-279932-bilr71ay	31	26	be	be	VB
cord-279932-bilr71ay	31	27	cancelled	cancel	VBN
cord-279932-bilr71ay	31	28	.	.	.
cord-279932-bilr71ay	32	1	However	however	RB
cord-279932-bilr71ay	32	2	,	,	,
cord-279932-bilr71ay	32	3	a	a	DT
cord-279932-bilr71ay	32	4	committee	committee	NN
cord-279932-bilr71ay	32	5	of	of	IN
cord-279932-bilr71ay	32	6	the	the	DT
cord-279932-bilr71ay	32	7	World	World	NNP
cord-279932-bilr71ay	32	8	Health	Health	NNP
cord-279932-bilr71ay	32	9	Organization	Organization	NNP
cord-279932-bilr71ay	32	10	and	and	CC
cord-279932-bilr71ay	32	11	a	a	DT
cord-279932-bilr71ay	32	12	committee	committee	NN
cord-279932-bilr71ay	32	13	of	of	IN
cord-279932-bilr71ay	32	14	the	the	DT
cord-279932-bilr71ay	32	15	National	National	NNP
cord-279932-bilr71ay	32	16	Institutes	Institutes	NNPS
cord-279932-bilr71ay	32	17	of	of	IN
cord-279932-bilr71ay	32	18	Health	Health	NNP
cord-279932-bilr71ay	32	19	have	have	VBP
cord-279932-bilr71ay	32	20	both	both	DT
cord-279932-bilr71ay	32	21	given	give	VBN
cord-279932-bilr71ay	32	22	provisional	provisional	JJ
cord-279932-bilr71ay	32	23	approval	approval	NN
cord-279932-bilr71ay	32	24	to	to	IN
cord-279932-bilr71ay	32	25	human	human	JJ
cord-279932-bilr71ay	32	26	challenges	challenge	NNS
cord-279932-bilr71ay	32	27	[	[	-LRB-
cord-279932-bilr71ay	32	28	11	11	CD
cord-279932-bilr71ay	32	29	,	,	,
cord-279932-bilr71ay	32	30	12	12	CD
cord-279932-bilr71ay	32	31	]	]	-RRB-
cord-279932-bilr71ay	32	32	.	.	.
cord-279932-bilr71ay	33	1	The	the	DT
cord-279932-bilr71ay	33	2	longer	long	RBR
cord-279932-bilr71ay	33	3	we	-PRON-	PRP
cord-279932-bilr71ay	33	4	hesitate	hesitate	VBP
cord-279932-bilr71ay	33	5	,	,	,
cord-279932-bilr71ay	33	6	the	the	DT
cord-279932-bilr71ay	33	7	less	less	RBR
cord-279932-bilr71ay	33	8	the	the	DT
cord-279932-bilr71ay	33	9	value	value	NN
cord-279932-bilr71ay	33	10	of	of	IN
cord-279932-bilr71ay	33	11	human	human	JJ
cord-279932-bilr71ay	33	12	challenge	challenge	NN
cord-279932-bilr71ay	33	13	trials	trial	NNS
cord-279932-bilr71ay	33	14	.	.	.
cord-279932-bilr71ay	34	1	Note	note	VB
cord-279932-bilr71ay	34	2	Potential	potential	JJ
cord-279932-bilr71ay	34	3	conflicts	conflict	NNS
cord-279932-bilr71ay	34	4	of	of	IN
cord-279932-bilr71ay	34	5	interest	interest	NN
cord-279932-bilr71ay	34	6	.	.	.
cord-279932-bilr71ay	35	1	S.	S.	NNP
cord-279932-bilr71ay	35	2	A.	a.	NN
cord-279932-bilr71ay	35	3	P.	P.	NNP
cord-279932-bilr71ay	35	4	is	be	VBZ
cord-279932-bilr71ay	35	5	a	a	DT
cord-279932-bilr71ay	35	6	consultant	consultant	NN
cord-279932-bilr71ay	35	7	to	to	IN
cord-279932-bilr71ay	35	8	numerous	numerous	JJ
cord-279932-bilr71ay	35	9	companies	company	NNS
cord-279932-bilr71ay	35	10	and	and	CC
cord-279932-bilr71ay	35	11	biotechs	biotech	NNS
cord-279932-bilr71ay	35	12	,	,	,
cord-279932-bilr71ay	35	13	none	none	NN
cord-279932-bilr71ay	35	14	of	of	IN
cord-279932-bilr71ay	35	15	which	which	WDT
cord-279932-bilr71ay	35	16	have	have	VBP
cord-279932-bilr71ay	35	17	indicated	indicate	VBN
cord-279932-bilr71ay	35	18	interest	interest	NN
cord-279932-bilr71ay	35	19	in	in	IN
cord-279932-bilr71ay	35	20	human	human	JJ
cord-279932-bilr71ay	35	21	challenge	challenge	NN
cord-279932-bilr71ay	35	22	trials	trial	NNS
cord-279932-bilr71ay	35	23	.	.	.
cord-279932-bilr71ay	36	1	The	the	DT
cord-279932-bilr71ay	36	2	author	author	NN
cord-279932-bilr71ay	36	3	has	have	VBZ
cord-279932-bilr71ay	36	4	submitted	submit	VBN
cord-279932-bilr71ay	36	5	the	the	DT
cord-279932-bilr71ay	36	6	ICMJE	ICMJE	NNP
cord-279932-bilr71ay	36	7	Form	Form	NNP
cord-279932-bilr71ay	36	8	for	for	IN
cord-279932-bilr71ay	36	9	Disclosure	Disclosure	NNP
cord-279932-bilr71ay	36	10	of	of	IN
cord-279932-bilr71ay	36	11	Potential	potential	JJ
cord-279932-bilr71ay	36	12	Conflicts	conflict	NNS
cord-279932-bilr71ay	36	13	of	of	IN
cord-279932-bilr71ay	36	14	Interest	interest	NN
cord-279932-bilr71ay	36	15	.	.	.
cord-279932-bilr71ay	37	1	Conflicts	conflict	NNS
cord-279932-bilr71ay	37	2	that	that	WDT
cord-279932-bilr71ay	37	3	the	the	DT
cord-279932-bilr71ay	37	4	editors	editor	NNS
cord-279932-bilr71ay	37	5	consider	consider	VBP
cord-279932-bilr71ay	37	6	relevant	relevant	JJ
cord-279932-bilr71ay	37	7	to	to	IN
cord-279932-bilr71ay	37	8	the	the	DT
cord-279932-bilr71ay	37	9	content	content	NN
cord-279932-bilr71ay	37	10	of	of	IN
cord-279932-bilr71ay	37	11	the	the	DT
cord-279932-bilr71ay	37	12	manuscript	manuscript	NN
cord-279932-bilr71ay	37	13	have	have	VBP
cord-279932-bilr71ay	37	14	been	be	VBN
cord-279932-bilr71ay	37	15	disclosed	disclose	VBN
cord-279932-bilr71ay	37	16	.	.	.
cord-279932-bilr71ay	37	17	 	 	_SP
cord-279932-bilr71ay	38	1	Evaluating	evaluate	VBG
cord-279932-bilr71ay	38	2	use	use	NN
cord-279932-bilr71ay	38	3	cases	case	NNS
cord-279932-bilr71ay	38	4	for	for	IN
cord-279932-bilr71ay	38	5	human	human	JJ
cord-279932-bilr71ay	38	6	challenge	challenge	NN
cord-279932-bilr71ay	38	7	trials	trial	NNS
cord-279932-bilr71ay	38	8	in	in	IN
cord-279932-bilr71ay	38	9	accelerating	accelerate	VBG
cord-279932-bilr71ay	38	10	SARS	SARS	NNP
cord-279932-bilr71ay	38	11	-	-	HYPH
cord-279932-bilr71ay	38	12	CoV-2	CoV-2	NNP
cord-279932-bilr71ay	38	13	vaccine	vaccine	NN
cord-279932-bilr71ay	38	14	development	development	NN
cord-279932-bilr71ay	38	15	Human	Human	NNP
cord-279932-bilr71ay	38	16	challenge	challenge	NN
cord-279932-bilr71ay	38	17	studies	study	NNS
cord-279932-bilr71ay	38	18	to	to	TO
cord-279932-bilr71ay	38	19	accelerate	accelerate	VB
cord-279932-bilr71ay	38	20	coronavirus	coronavirus	NN
cord-279932-bilr71ay	38	21	vaccine	vaccine	NN
cord-279932-bilr71ay	38	22	licensure	licensure	NN
cord-279932-bilr71ay	38	23	Extraordinary	extraordinary	JJ
cord-279932-bilr71ay	38	24	diseases	disease	NNS
cord-279932-bilr71ay	38	25	require	require	VBP
cord-279932-bilr71ay	38	26	extraordinary	extraordinary	JJ
cord-279932-bilr71ay	38	27	solutions	solution	NNS
cord-279932-bilr71ay	39	1	Why	why	WRB
cord-279932-bilr71ay	39	2	challenge	challenge	NN
cord-279932-bilr71ay	39	3	trials	trial	NNS
cord-279932-bilr71ay	39	4	of	of	IN
cord-279932-bilr71ay	39	5	SARS	SARS	NNP
cord-279932-bilr71ay	39	6	-	-	HYPH
cord-279932-bilr71ay	39	7	CoV-2	CoV-2	NNP
cord-279932-bilr71ay	39	8	vaccines	vaccine	NNS
cord-279932-bilr71ay	39	9	could	could	MD
cord-279932-bilr71ay	39	10	be	be	VB
cord-279932-bilr71ay	39	11	ethical	ethical	JJ
cord-279932-bilr71ay	39	12	despite	despite	IN
cord-279932-bilr71ay	39	13	risk	risk	NN
cord-279932-bilr71ay	39	14	of	of	IN
cord-279932-bilr71ay	39	15	severe	severe	JJ
cord-279932-bilr71ay	39	16	adverse	adverse	JJ
cord-279932-bilr71ay	39	17	events	event	NNS
cord-279932-bilr71ay	39	18	Ethics	ethic	NNS
cord-279932-bilr71ay	39	19	of	of	IN
cord-279932-bilr71ay	39	20	controlled	control	VBN
cord-279932-bilr71ay	39	21	human	human	JJ
cord-279932-bilr71ay	39	22	infection	infection	NN
cord-279932-bilr71ay	39	23	to	to	TO
cord-279932-bilr71ay	39	24	address	address	VB
cord-279932-bilr71ay	39	25	COVID-19	COVID-19	NNP
cord-279932-bilr71ay	39	26	COVID-19	COVID-19	NNP
cord-279932-bilr71ay	39	27	human	human	JJ
cord-279932-bilr71ay	39	28	challenge	challenge	NN
cord-279932-bilr71ay	39	29	studies	study	NNS
cord-279932-bilr71ay	39	30	:	:	:
cord-279932-bilr71ay	39	31	ethical	ethical	JJ
cord-279932-bilr71ay	39	32	issues	issue	NNS
cord-279932-bilr71ay	40	1	A	a	DT
cord-279932-bilr71ay	40	2	strategic	strategic	JJ
cord-279932-bilr71ay	40	3	approach	approach	NN
cord-279932-bilr71ay	40	4	to	to	IN
cord-279932-bilr71ay	41	1	COVID-19	covid-19	JJ
cord-279932-bilr71ay	41	2	vaccine	vaccine	NN
cord-279932-bilr71ay	41	3	R&D	r&d	NN
cord-279932-bilr71ay	41	4	Severe	severe	JJ
cord-279932-bilr71ay	42	1	acute	acute	JJ
cord-279932-bilr71ay	42	2	respiratory	respiratory	JJ
cord-279932-bilr71ay	42	3	syndrome	syndrome	NN
cord-279932-bilr71ay	42	4	coronavirus	coronavirus	NN
cord-279932-bilr71ay	42	5	2	2	CD
cord-279932-bilr71ay	42	6	human	human	JJ
cord-279932-bilr71ay	42	7	challenge	challenge	NN
cord-279932-bilr71ay	42	8	trials	trial	NNS
cord-279932-bilr71ay	42	9	:	:	:
cord-279932-bilr71ay	42	10	too	too	RB
cord-279932-bilr71ay	42	11	risky	risky	JJ
cord-279932-bilr71ay	42	12	,	,	,
cord-279932-bilr71ay	42	13	too	too	RB
cord-279932-bilr71ay	42	14	soon	soon	RB
cord-279932-bilr71ay	43	1	An	an	DT
cord-279932-bilr71ay	43	2	ethical	ethical	JJ
cord-279932-bilr71ay	43	3	path	path	NN
cord-279932-bilr71ay	43	4	to	to	IN
cord-279932-bilr71ay	43	5	a	a	DT
cord-279932-bilr71ay	43	6	COVID	covid	JJ
cord-279932-bilr71ay	43	7	vaccine	vaccine	NN
cord-279932-bilr71ay	43	8	Estimates	estimate	NNS
cord-279932-bilr71ay	43	9	of	of	IN
cord-279932-bilr71ay	43	10	the	the	DT
cord-279932-bilr71ay	43	11	severity	severity	NN
cord-279932-bilr71ay	43	12	of	of	IN
cord-279932-bilr71ay	43	13	coronavirus	coronavirus	NN
cord-279932-bilr71ay	43	14	disease	disease	NN
cord-279932-bilr71ay	43	15	2019	2019	CD
cord-279932-bilr71ay	43	16	:	:	:
cord-279932-bilr71ay	43	17	a	a	DT
cord-279932-bilr71ay	43	18	model	model	NN
cord-279932-bilr71ay	43	19	-	-	HYPH
cord-279932-bilr71ay	43	20	based	base	VBN
cord-279932-bilr71ay	43	21	analysis	analysis	NN
cord-279932-bilr71ay	43	22	Accelerating	accelerate	VBG
cord-279932-bilr71ay	43	23	development	development	NN
cord-279932-bilr71ay	43	24	of	of	IN
cord-279932-bilr71ay	43	25	SARS	SARS	NNP
cord-279932-bilr71ay	43	26	-	-	HYPH
cord-279932-bilr71ay	43	27	CoV-2	CoV-2	NNP
cord-279932-bilr71ay	43	28	vaccines	vaccine	NNS
cord-279932-bilr71ay	44	1	-the	-the	DT
cord-279932-bilr71ay	44	2	role	role	NN
cord-279932-bilr71ay	44	3	for	for	IN
cord-279932-bilr71ay	44	4	controlled	control	VBN
cord-279932-bilr71ay	44	5	human	human	JJ
cord-279932-bilr71ay	44	6	infection	infection	NN
cord-279932-bilr71ay	44	7	models	model	NNS
cord-279932-bilr71ay	44	8	WHO	who	WP
cord-279932-bilr71ay	44	9	advisory	advisory	JJ
cord-279932-bilr71ay	44	10	group	group	NN
cord-279932-bilr71ay	44	11	tasked	task	VBN
cord-279932-bilr71ay	44	12	to	to	TO
cord-279932-bilr71ay	44	13	consider	consider	VB
cord-279932-bilr71ay	44	14	the	the	DT
cord-279932-bilr71ay	44	15	feasibility	feasibility	NN
cord-279932-bilr71ay	44	16	,	,	,
cord-279932-bilr71ay	44	17	potential	potential	JJ
cord-279932-bilr71ay	44	18	value	value	NN
cord-279932-bilr71ay	44	19	,	,	,
cord-279932-bilr71ay	44	20	and	and	CC
cord-279932-bilr71ay	44	21	limitations	limitation	NNS
cord-279932-bilr71ay	44	22	of	of	IN
cord-279932-bilr71ay	44	23	establishing	establish	VBG
cord-279932-bilr71ay	44	24	a	a	DT
cord-279932-bilr71ay	44	25	closely	closely	RB
cord-279932-bilr71ay	44	26	monitored	monitor	VBN
cord-279932-bilr71ay	44	27	challenge	challenge	NN
cord-279932-bilr71ay	44	28	model	model	NN
cord-279932-bilr71ay	44	29	of	of	IN
cord-279932-bilr71ay	44	30	experimental	experimental	JJ
cord-279932-bilr71ay	44	31	COVID-19	covid-19	CD
cord-279932-bilr71ay	44	32	infection	infection	NN
cord-279932-bilr71ay	44	33	and	and	CC
cord-279932-bilr71ay	44	34	illness	illness	NN
cord-279932-bilr71ay	44	35	in	in	IN
cord-279932-bilr71ay	44	36	healthy	healthy	JJ
cord-279932-bilr71ay	44	37	young	young	JJ
cord-279932-bilr71ay	44	38	adult	adult	NN
cord-279932-bilr71ay	44	39	volunteers	volunteer	NNS