id sid tid token lemma pos cord-275349-b35pt3mo 1 1 key key NNP cord-275349-b35pt3mo 1 2 : : : cord-275349-b35pt3mo 1 3 cord-275349-b35pt3mo cord-275349-b35pt3mo NN cord-275349-b35pt3mo 1 4 authors author NNS cord-275349-b35pt3mo 1 5 : : : cord-275349-b35pt3mo 1 6 Lenz Lenz NNP cord-275349-b35pt3mo 1 7 , , , cord-275349-b35pt3mo 1 8 Heinz Heinz NNP cord-275349-b35pt3mo 1 9 - - HYPH cord-275349-b35pt3mo 1 10 Josef Josef NNP cord-275349-b35pt3mo 1 11 ; ; : cord-275349-b35pt3mo 1 12 Richardson Richardson NNP cord-275349-b35pt3mo 1 13 , , , cord-275349-b35pt3mo 1 14 Peter Peter NNP cord-275349-b35pt3mo 1 15 ; ; : cord-275349-b35pt3mo 1 16 Stebbing Stebbing NNP cord-275349-b35pt3mo 1 17 , , , cord-275349-b35pt3mo 1 18 Justin Justin NNP cord-275349-b35pt3mo 1 19 title title NN cord-275349-b35pt3mo 1 20 : : : cord-275349-b35pt3mo 1 21 The the DT cord-275349-b35pt3mo 1 22 Emergence Emergence NNP cord-275349-b35pt3mo 1 23 of of IN cord-275349-b35pt3mo 1 24 Baricitinib Baricitinib NNP cord-275349-b35pt3mo 1 25 : : : cord-275349-b35pt3mo 1 26 A a DT cord-275349-b35pt3mo 1 27 Story Story NNP cord-275349-b35pt3mo 1 28 of of IN cord-275349-b35pt3mo 1 29 Tortoises Tortoises NNPS cord-275349-b35pt3mo 1 30 Versus Versus NNP cord-275349-b35pt3mo 1 31 Hares Hares NNPS cord-275349-b35pt3mo 1 32 date date NN cord-275349-b35pt3mo 1 33 : : : cord-275349-b35pt3mo 1 34 2020 2020 CD cord-275349-b35pt3mo 1 35 - - HYPH cord-275349-b35pt3mo 1 36 07 07 CD cord-275349-b35pt3mo 1 37 - - HYPH cord-275349-b35pt3mo 1 38 06 06 CD cord-275349-b35pt3mo 1 39 journal journal NN cord-275349-b35pt3mo 1 40 : : : cord-275349-b35pt3mo 2 1 Clin Clin NNP cord-275349-b35pt3mo 2 2 Infect infect VB cord-275349-b35pt3mo 2 3 Dis dis NN cord-275349-b35pt3mo 2 4 DOI doi NN cord-275349-b35pt3mo 3 1 : : : cord-275349-b35pt3mo 3 2 10.1093 10.1093 CD cord-275349-b35pt3mo 3 3 / / SYM cord-275349-b35pt3mo 3 4 cid cid NN cord-275349-b35pt3mo 3 5 / / SYM cord-275349-b35pt3mo 3 6 ciaa940 ciaa940 NNP cord-275349-b35pt3mo 3 7 sha sha NNP cord-275349-b35pt3mo 3 8 : : : cord-275349-b35pt3mo 4 1 a79793fb975ca389ed75677309adb42386b80e17 a79793fb975ca389ed75677309adb42386b80e17 NNP cord-275349-b35pt3mo 5 1 doc_id doc_id CD cord-275349-b35pt3mo 6 1 : : : cord-275349-b35pt3mo 6 2 275349 275349 CD cord-275349-b35pt3mo 6 3 cord_uid cord_uid NNS cord-275349-b35pt3mo 6 4 : : : cord-275349-b35pt3mo 7 1 b35pt3mo b35pt3mo NNP cord-275349-b35pt3mo 7 2 nan nan NNP cord-275349-b35pt3mo 7 3 Keywords Keywords NNP cord-275349-b35pt3mo 7 4 . . . cord-275349-b35pt3mo 8 1 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 8 2 ; ; : cord-275349-b35pt3mo 8 3 SARS SARS NNP cord-275349-b35pt3mo 8 4 - - HYPH cord-275349-b35pt3mo 8 5 CoV-2 CoV-2 NNP cord-275349-b35pt3mo 8 6 ; ; : cord-275349-b35pt3mo 8 7 barictinib barictinib NNP cord-275349-b35pt3mo 8 8 ; ; : cord-275349-b35pt3mo 8 9 anti anti JJ cord-275349-b35pt3mo 8 10 - - JJ cord-275349-b35pt3mo 8 11 viral viral JJ cord-275349-b35pt3mo 8 12 ; ; : cord-275349-b35pt3mo 8 13 cytokine cytokine NN cord-275349-b35pt3mo 8 14 storm storm NN cord-275349-b35pt3mo 8 15 ; ; : cord-275349-b35pt3mo 8 16 trial trial NN cord-275349-b35pt3mo 8 17 . . . cord-275349-b35pt3mo 9 1 Baricitinib Baricitinib NNP cord-275349-b35pt3mo 9 2 is be VBZ cord-275349-b35pt3mo 9 3 a a DT cord-275349-b35pt3mo 9 4 once once RB cord-275349-b35pt3mo 9 5 daily daily RB cord-275349-b35pt3mo 9 6 orally orally RB cord-275349-b35pt3mo 9 7 administered administer VBD cord-275349-b35pt3mo 9 8 JAK1/2 JAK1/2 NNP cord-275349-b35pt3mo 9 9 inhibitor inhibitor NN cord-275349-b35pt3mo 9 10 , , , cord-275349-b35pt3mo 9 11 which which WDT cord-275349-b35pt3mo 9 12 inhibits inhibit VBZ cord-275349-b35pt3mo 9 13 the the DT cord-275349-b35pt3mo 9 14 signaling signaling NN cord-275349-b35pt3mo 9 15 of of IN cord-275349-b35pt3mo 9 16 many many JJ cord-275349-b35pt3mo 9 17 cytokines cytokine NNS cord-275349-b35pt3mo 9 18 and and CC cord-275349-b35pt3mo 9 19 has have VBZ cord-275349-b35pt3mo 9 20 been be VBN cord-275349-b35pt3mo 9 21 approved approve VBN cord-275349-b35pt3mo 9 22 for for IN cord-275349-b35pt3mo 9 23 the the DT cord-275349-b35pt3mo 9 24 treatment treatment NN cord-275349-b35pt3mo 9 25 of of IN cord-275349-b35pt3mo 9 26 moderate moderate JJ cord-275349-b35pt3mo 9 27 to to IN cord-275349-b35pt3mo 9 28 severe severe JJ cord-275349-b35pt3mo 9 29 rheumatoid rheumatoid NN cord-275349-b35pt3mo 9 30 arthritis arthritis NN cord-275349-b35pt3mo 9 31 ( ( -LRB- cord-275349-b35pt3mo 9 32 RA RA NNP cord-275349-b35pt3mo 9 33 ) ) -RRB- cord-275349-b35pt3mo 9 34 based base VBN cord-275349-b35pt3mo 9 35 on on IN cord-275349-b35pt3mo 9 36 long long JJ cord-275349-b35pt3mo 9 37 - - HYPH cord-275349-b35pt3mo 9 38 term term NN cord-275349-b35pt3mo 9 39 randomized randomize VBN cord-275349-b35pt3mo 9 40 dosing dosing NN cord-275349-b35pt3mo 9 41 against against IN cord-275349-b35pt3mo 9 42 both both DT cord-275349-b35pt3mo 9 43 placebo placebo NN cord-275349-b35pt3mo 9 44 and and CC cord-275349-b35pt3mo 9 45 standard standard NN cord-275349-b35pt3mo 9 46 of of IN cord-275349-b35pt3mo 9 47 care care NN cord-275349-b35pt3mo 9 48 [ [ -LRB- cord-275349-b35pt3mo 9 49 1 1 CD cord-275349-b35pt3mo 9 50 ] ] -RRB- cord-275349-b35pt3mo 9 51 , , , cord-275349-b35pt3mo 9 52 notably notably RB cord-275349-b35pt3mo 9 53 tumor tumor NN cord-275349-b35pt3mo 9 54 necrosis necrosis NN cord-275349-b35pt3mo 9 55 factor factor NN cord-275349-b35pt3mo 9 56 ( ( -LRB- cord-275349-b35pt3mo 9 57 TNF)alpha tnf)alpha CD cord-275349-b35pt3mo 9 58 blockade blockade NN cord-275349-b35pt3mo 9 59 . . . cord-275349-b35pt3mo 10 1 Its -PRON- PRP$ cord-275349-b35pt3mo 10 2 use use NN cord-275349-b35pt3mo 10 3 for for IN cord-275349-b35pt3mo 10 4 the the DT cord-275349-b35pt3mo 10 5 treatment treatment NN cord-275349-b35pt3mo 10 6 of of IN cord-275349-b35pt3mo 10 7 coronavirus coronavirus NN cord-275349-b35pt3mo 10 8 disease disease NN cord-275349-b35pt3mo 10 9 2019 2019 CD cord-275349-b35pt3mo 10 10 ( ( -LRB- cord-275349-b35pt3mo 10 11 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 10 12 ) ) -RRB- cord-275349-b35pt3mo 10 13 was be VBD cord-275349-b35pt3mo 10 14 originally originally RB cord-275349-b35pt3mo 10 15 suggested suggest VBN cord-275349-b35pt3mo 10 16 after after IN cord-275349-b35pt3mo 10 17 a a DT cord-275349-b35pt3mo 10 18 search search NN cord-275349-b35pt3mo 10 19 of of IN cord-275349-b35pt3mo 10 20 the the DT cord-275349-b35pt3mo 10 21 extensive extensive JJ cord-275349-b35pt3mo 10 22 BenevolentAI benevolentai JJ cord-275349-b35pt3mo 10 23 knowledge knowledge NN cord-275349-b35pt3mo 10 24 graph graph NN cord-275349-b35pt3mo 10 25 for for IN cord-275349-b35pt3mo 10 26 approved approve VBN cord-275349-b35pt3mo 10 27 drugs drug NNS cord-275349-b35pt3mo 10 28 that that WDT cord-275349-b35pt3mo 10 29 could could MD cord-275349-b35pt3mo 10 30 be be VB cord-275349-b35pt3mo 10 31 used use VBN cord-275349-b35pt3mo 10 32 in in IN cord-275349-b35pt3mo 10 33 this this DT cord-275349-b35pt3mo 10 34 pandemic pandemic NN cord-275349-b35pt3mo 10 35 [ [ -LRB- cord-275349-b35pt3mo 10 36 2 2 CD cord-275349-b35pt3mo 10 37 ] ] -RRB- cord-275349-b35pt3mo 10 38 . . . cord-275349-b35pt3mo 11 1 An an DT cord-275349-b35pt3mo 11 2 advantage advantage NN cord-275349-b35pt3mo 11 3 of of IN cord-275349-b35pt3mo 11 4 approved approve VBN cord-275349-b35pt3mo 11 5 drugs drug NNS cord-275349-b35pt3mo 11 6 is be VBZ cord-275349-b35pt3mo 11 7 that that IN cord-275349-b35pt3mo 11 8 they -PRON- PRP cord-275349-b35pt3mo 11 9 have have VBP cord-275349-b35pt3mo 11 10 a a DT cord-275349-b35pt3mo 11 11 known know VBN cord-275349-b35pt3mo 11 12 safety safety NN cord-275349-b35pt3mo 11 13 profile profile NN cord-275349-b35pt3mo 11 14 and and CC cord-275349-b35pt3mo 11 15 can can MD cord-275349-b35pt3mo 11 16 therefore therefore RB cord-275349-b35pt3mo 11 17 be be VB cord-275349-b35pt3mo 11 18 rapidly rapidly RB cord-275349-b35pt3mo 11 19 approved approve VBN cord-275349-b35pt3mo 11 20 in in IN cord-275349-b35pt3mo 11 21 fast fast JJ cord-275349-b35pt3mo 11 22 moving move VBG cord-275349-b35pt3mo 11 23 pandemics pandemic NNS cord-275349-b35pt3mo 11 24 . . . cord-275349-b35pt3mo 12 1 The the DT cord-275349-b35pt3mo 12 2 artificial artificial JJ cord-275349-b35pt3mo 12 3 intelligence intelligence NN cord-275349-b35pt3mo 12 4 algorithms algorithm NNS cord-275349-b35pt3mo 12 5 predicted predict VBD cord-275349-b35pt3mo 12 6 that that IN cord-275349-b35pt3mo 12 7 baricitinib baricitinib NN cord-275349-b35pt3mo 12 8 would would MD cord-275349-b35pt3mo 12 9 inhibit inhibit VB cord-275349-b35pt3mo 12 10 severe severe JJ cord-275349-b35pt3mo 12 11 acute acute JJ cord-275349-b35pt3mo 12 12 respiratory respiratory JJ cord-275349-b35pt3mo 12 13 syndrome syndrome NN cord-275349-b35pt3mo 12 14 coronavirus coronavirus NN cord-275349-b35pt3mo 12 15 2 2 CD cord-275349-b35pt3mo 13 1 ( ( -LRB- cord-275349-b35pt3mo 13 2 SARS SARS NNP cord-275349-b35pt3mo 13 3 - - HYPH cord-275349-b35pt3mo 13 4 CoV-2 CoV-2 NNP cord-275349-b35pt3mo 13 5 ) ) -RRB- cord-275349-b35pt3mo 13 6 infection infection NN cord-275349-b35pt3mo 13 7 of of IN cord-275349-b35pt3mo 13 8 cells cell NNS cord-275349-b35pt3mo 13 9 [ [ -LRB- cord-275349-b35pt3mo 13 10 2 2 CD cord-275349-b35pt3mo 13 11 ] ] -RRB- cord-275349-b35pt3mo 13 12 , , , cord-275349-b35pt3mo 13 13 ( ( -LRB- cord-275349-b35pt3mo 13 14 an an DT cord-275349-b35pt3mo 13 15 effect effect NN cord-275349-b35pt3mo 13 16 later later RB cord-275349-b35pt3mo 13 17 confirmed confirm VBN cord-275349-b35pt3mo 13 18 in in IN cord-275349-b35pt3mo 13 19 human human JJ cord-275349-b35pt3mo 13 20 liver liver NN cord-275349-b35pt3mo 13 21 spheroids spheroid NNS cord-275349-b35pt3mo 13 22 ) ) -RRB- cord-275349-b35pt3mo 13 23 [ [ -LRB- cord-275349-b35pt3mo 13 24 3 3 CD cord-275349-b35pt3mo 13 25 ] ] -RRB- cord-275349-b35pt3mo 13 26 , , , cord-275349-b35pt3mo 13 27 combined combine VBN cord-275349-b35pt3mo 13 28 with with IN cord-275349-b35pt3mo 13 29 its -PRON- PRP$ cord-275349-b35pt3mo 13 30 better well RBR cord-275349-b35pt3mo 13 31 - - HYPH cord-275349-b35pt3mo 13 32 known know VBN cord-275349-b35pt3mo 13 33 anti anti JJ cord-275349-b35pt3mo 13 34 - - JJ cord-275349-b35pt3mo 13 35 inflammatory inflammatory JJ cord-275349-b35pt3mo 13 36 properties property NNS cord-275349-b35pt3mo 13 37 . . . cord-275349-b35pt3mo 14 1 The the DT cord-275349-b35pt3mo 14 2 doses dose NNS cord-275349-b35pt3mo 14 3 required require VBN cord-275349-b35pt3mo 14 4 were be VBD cord-275349-b35pt3mo 14 5 predicted predict VBN cord-275349-b35pt3mo 14 6 to to TO cord-275349-b35pt3mo 14 7 be be VB cord-275349-b35pt3mo 14 8 the the DT cord-275349-b35pt3mo 14 9 same same JJ cord-275349-b35pt3mo 14 10 as as IN cord-275349-b35pt3mo 14 11 used use VBN cord-275349-b35pt3mo 14 12 for for IN cord-275349-b35pt3mo 14 13 the the DT cord-275349-b35pt3mo 14 14 treatment treatment NN cord-275349-b35pt3mo 14 15 of of IN cord-275349-b35pt3mo 14 16 RA RA NNP cord-275349-b35pt3mo 14 17 . . . cord-275349-b35pt3mo 15 1 At at IN cord-275349-b35pt3mo 15 2 these these DT cord-275349-b35pt3mo 15 3 doses dose NNS cord-275349-b35pt3mo 15 4 , , , cord-275349-b35pt3mo 15 5 interleukin interleukin NN cord-275349-b35pt3mo 15 6 6 6 CD cord-275349-b35pt3mo 15 7 ( ( -LRB- cord-275349-b35pt3mo 15 8 IL-6 IL-6 NNP cord-275349-b35pt3mo 15 9 ) ) -RRB- cord-275349-b35pt3mo 15 10 levels level NNS cord-275349-b35pt3mo 15 11 were be VBD cord-275349-b35pt3mo 15 12 reduced reduce VBN cord-275349-b35pt3mo 15 13 both both CC cord-275349-b35pt3mo 15 14 in in IN cord-275349-b35pt3mo 15 15 COVID19 covid19 NN cord-275349-b35pt3mo 15 16 patients patient NNS cord-275349-b35pt3mo 15 17 as as RB cord-275349-b35pt3mo 15 18 well well RB cord-275349-b35pt3mo 15 19 as as IN cord-275349-b35pt3mo 15 20 dose dose NN cord-275349-b35pt3mo 15 21 dependently dependently RB cord-275349-b35pt3mo 15 22 in in IN cord-275349-b35pt3mo 15 23 RA RA NNP cord-275349-b35pt3mo 15 24 patients patient NNS cord-275349-b35pt3mo 15 25 in in IN cord-275349-b35pt3mo 15 26 a a DT cord-275349-b35pt3mo 15 27 previous previous JJ cord-275349-b35pt3mo 15 28 phase phase NN cord-275349-b35pt3mo 15 29 2b 2b CD cord-275349-b35pt3mo 15 30 randomized randomized JJ cord-275349-b35pt3mo 15 31 RA RA NNP cord-275349-b35pt3mo 15 32 trial trial NN cord-275349-b35pt3mo 15 33 , , , cord-275349-b35pt3mo 15 34 the the DT cord-275349-b35pt3mo 15 35 first first JJ cord-275349-b35pt3mo 15 36 time time NN cord-275349-b35pt3mo 15 37 this this DT cord-275349-b35pt3mo 15 38 was be VBD cord-275349-b35pt3mo 15 39 shown show VBN cord-275349-b35pt3mo 15 40 in in IN cord-275349-b35pt3mo 15 41 humans human NNS cord-275349-b35pt3mo 15 42 [ [ -LRB- cord-275349-b35pt3mo 15 43 4 4 CD cord-275349-b35pt3mo 15 44 ] ] -RRB- cord-275349-b35pt3mo 15 45 . . . cord-275349-b35pt3mo 16 1 What what WP cord-275349-b35pt3mo 16 2 was be VBD cord-275349-b35pt3mo 16 3 more more RBR cord-275349-b35pt3mo 16 4 intriguing intriguing JJ cord-275349-b35pt3mo 16 5 was be VBD cord-275349-b35pt3mo 16 6 its -PRON- PRP$ cord-275349-b35pt3mo 16 7 inhibition inhibition NN cord-275349-b35pt3mo 16 8 of of IN cord-275349-b35pt3mo 16 9 members member NNS cord-275349-b35pt3mo 16 10 of of IN cord-275349-b35pt3mo 16 11 the the DT cord-275349-b35pt3mo 16 12 numb numb JJ cord-275349-b35pt3mo 16 13 associated associate VBN cord-275349-b35pt3mo 16 14 kinase kinase NN cord-275349-b35pt3mo 16 15 family family NN cord-275349-b35pt3mo 16 16 , , , cord-275349-b35pt3mo 16 17 thought think VBN cord-275349-b35pt3mo 16 18 in in IN cord-275349-b35pt3mo 16 19 turn turn NN cord-275349-b35pt3mo 16 20 to to TO cord-275349-b35pt3mo 16 21 translate translate VB cord-275349-b35pt3mo 16 22 to to IN cord-275349-b35pt3mo 16 23 reduced reduce VBN cord-275349-b35pt3mo 16 24 AP-2 AP-2 NNP cord-275349-b35pt3mo 16 25 mediated mediate VBN cord-275349-b35pt3mo 16 26 viral viral JJ cord-275349-b35pt3mo 16 27 propagation propagation NN cord-275349-b35pt3mo 16 28 early early RB cord-275349-b35pt3mo 16 29 in in IN cord-275349-b35pt3mo 16 30 the the DT cord-275349-b35pt3mo 16 31 infectious infectious JJ cord-275349-b35pt3mo 16 32 cycle cycle NN cord-275349-b35pt3mo 16 33 , , , cord-275349-b35pt3mo 16 34 suggesting suggest VBG cord-275349-b35pt3mo 16 35 antiviral antiviral JJ cord-275349-b35pt3mo 16 36 activity activity NN cord-275349-b35pt3mo 16 37 ; ; : cord-275349-b35pt3mo 16 38 this this DT cord-275349-b35pt3mo 16 39 was be VBD cord-275349-b35pt3mo 16 40 shown show VBN cord-275349-b35pt3mo 16 41 in in IN cord-275349-b35pt3mo 16 42 liver liver NN cord-275349-b35pt3mo 16 43 spheroid spheroid NN cord-275349-b35pt3mo 16 44 models model NNS cord-275349-b35pt3mo 16 45 , , , cord-275349-b35pt3mo 16 46 which which WDT cord-275349-b35pt3mo 16 47 express express VBP cord-275349-b35pt3mo 16 48 detectable detectable JJ cord-275349-b35pt3mo 16 49 albeit albeit IN cord-275349-b35pt3mo 16 50 low low JJ cord-275349-b35pt3mo 16 51 levels level NNS cord-275349-b35pt3mo 16 52 of of IN cord-275349-b35pt3mo 16 53 the the DT cord-275349-b35pt3mo 16 54 ACE2 ACE2 NNP cord-275349-b35pt3mo 16 55 receptor receptor NN cord-275349-b35pt3mo 16 56 . . . cord-275349-b35pt3mo 17 1 In in IN cord-275349-b35pt3mo 17 2 hospitalized hospitalize VBN cord-275349-b35pt3mo 17 3 patients patient NNS cord-275349-b35pt3mo 17 4 it -PRON- PRP cord-275349-b35pt3mo 17 5 is be VBZ cord-275349-b35pt3mo 17 6 anticipated anticipate VBN cord-275349-b35pt3mo 17 7 that that IN cord-275349-b35pt3mo 17 8 residual residual JJ cord-275349-b35pt3mo 17 9 virus virus NN cord-275349-b35pt3mo 17 10 that that WDT cord-275349-b35pt3mo 17 11 propagates propagate VBZ cord-275349-b35pt3mo 17 12 itself -PRON- PRP cord-275349-b35pt3mo 17 13 in in IN cord-275349-b35pt3mo 17 14 airway airway NN cord-275349-b35pt3mo 17 15 epithelial epithelial JJ cord-275349-b35pt3mo 17 16 tissues tissue NNS cord-275349-b35pt3mo 17 17 maintains maintain VBZ cord-275349-b35pt3mo 17 18 and and CC cord-275349-b35pt3mo 17 19 amplifies amplify VBZ cord-275349-b35pt3mo 17 20 the the DT cord-275349-b35pt3mo 17 21 exaggerated exaggerated JJ cord-275349-b35pt3mo 17 22 inflammatory inflammatory JJ cord-275349-b35pt3mo 17 23 response response NN cord-275349-b35pt3mo 17 24 typical typical JJ cord-275349-b35pt3mo 17 25 of of IN cord-275349-b35pt3mo 17 26 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 17 27 . . . cord-275349-b35pt3mo 18 1 Consequently consequently RB cord-275349-b35pt3mo 18 2 , , , cord-275349-b35pt3mo 18 3 the the DT cord-275349-b35pt3mo 18 4 combined combine VBN cord-275349-b35pt3mo 18 5 potential potential JJ cord-275349-b35pt3mo 18 6 antiviral antiviral JJ cord-275349-b35pt3mo 18 7 and and CC cord-275349-b35pt3mo 18 8 anti anti JJ cord-275349-b35pt3mo 18 9 - - JJ cord-275349-b35pt3mo 18 10 inflammatory inflammatory JJ cord-275349-b35pt3mo 18 11 effects effect NNS cord-275349-b35pt3mo 18 12 of of IN cord-275349-b35pt3mo 18 13 this this DT cord-275349-b35pt3mo 18 14 dually dually RB cord-275349-b35pt3mo 18 15 acting act VBG cord-275349-b35pt3mo 18 16 drug drug NN cord-275349-b35pt3mo 18 17 could could MD cord-275349-b35pt3mo 18 18 be be VB cord-275349-b35pt3mo 18 19 ideal ideal JJ cord-275349-b35pt3mo 18 20 for for IN cord-275349-b35pt3mo 18 21 halting halt VBG cord-275349-b35pt3mo 18 22 the the DT cord-275349-b35pt3mo 18 23 progression progression NN cord-275349-b35pt3mo 18 24 of of IN cord-275349-b35pt3mo 18 25 the the DT cord-275349-b35pt3mo 18 26 disease disease NN cord-275349-b35pt3mo 18 27 in in IN cord-275349-b35pt3mo 18 28 hospitalized hospitalize VBN cord-275349-b35pt3mo 18 29 patients patient NNS cord-275349-b35pt3mo 18 30 , , , cord-275349-b35pt3mo 18 31 when when WRB cord-275349-b35pt3mo 18 32 taken take VBN cord-275349-b35pt3mo 18 33 for for IN cord-275349-b35pt3mo 18 34 a a DT cord-275349-b35pt3mo 18 35 limited limited JJ cord-275349-b35pt3mo 18 36 duration duration NN cord-275349-b35pt3mo 18 37 . . . cord-275349-b35pt3mo 19 1 At at IN cord-275349-b35pt3mo 19 2 the the DT cord-275349-b35pt3mo 19 3 University University NNP cord-275349-b35pt3mo 19 4 of of IN cord-275349-b35pt3mo 19 5 Southern Southern NNP cord-275349-b35pt3mo 19 6 California California NNP cord-275349-b35pt3mo 19 7 now now RB cord-275349-b35pt3mo 19 8 , , , cord-275349-b35pt3mo 19 9 a a DT cord-275349-b35pt3mo 19 10 randomized randomized JJ cord-275349-b35pt3mo 19 11 placebo placebo NN cord-275349-b35pt3mo 19 12 - - HYPH cord-275349-b35pt3mo 19 13 controlled control VBN cord-275349-b35pt3mo 19 14 phase phase NN cord-275349-b35pt3mo 19 15 2 2 CD cord-275349-b35pt3mo 19 16 study study NN cord-275349-b35pt3mo 19 17 with with IN cord-275349-b35pt3mo 19 18 remdesivir remdesivir NNP cord-275349-b35pt3mo 19 19 with with IN cord-275349-b35pt3mo 19 20 / / SYM cord-275349-b35pt3mo 19 21 without without IN cord-275349-b35pt3mo 19 22 baricitinib baricitinib NNP cord-275349-b35pt3mo 19 23 is be VBZ cord-275349-b35pt3mo 19 24 ongoing ongoing JJ cord-275349-b35pt3mo 19 25 to to TO cord-275349-b35pt3mo 19 26 test test VB cord-275349-b35pt3mo 19 27 the the DT cord-275349-b35pt3mo 19 28 efficacy efficacy NN cord-275349-b35pt3mo 19 29 to to TO cord-275349-b35pt3mo 19 30 prevent prevent VB cord-275349-b35pt3mo 19 31 mechanical mechanical JJ cord-275349-b35pt3mo 19 32 ventilation ventilation NN cord-275349-b35pt3mo 19 33 including include VBG cord-275349-b35pt3mo 19 34 significant significant JJ cord-275349-b35pt3mo 19 35 biomarker biomarker NN cord-275349-b35pt3mo 19 36 research research NN cord-275349-b35pt3mo 19 37 . . . cord-275349-b35pt3mo 20 1 In in IN cord-275349-b35pt3mo 20 2 this this DT cord-275349-b35pt3mo 20 3 issue issue NN cord-275349-b35pt3mo 20 4 of of IN cord-275349-b35pt3mo 20 5 Clinical Clinical NNP cord-275349-b35pt3mo 20 6 Infectious Infectious NNP cord-275349-b35pt3mo 20 7 Diseases Diseases NNPS cord-275349-b35pt3mo 20 8 , , , cord-275349-b35pt3mo 20 9 Titanji Titanji NNP cord-275349-b35pt3mo 20 10 et et FW cord-275349-b35pt3mo 20 11 al al NNP cord-275349-b35pt3mo 20 12 describe describe VB cord-275349-b35pt3mo 20 13 the the DT cord-275349-b35pt3mo 20 14 outcome outcome NN cord-275349-b35pt3mo 20 15 of of IN cord-275349-b35pt3mo 20 16 15 15 CD cord-275349-b35pt3mo 20 17 moderate moderate JJ cord-275349-b35pt3mo 20 18 - - HYPH cord-275349-b35pt3mo 20 19 to to TO cord-275349-b35pt3mo 20 20 - - HYPH cord-275349-b35pt3mo 20 21 critically critically RB cord-275349-b35pt3mo 20 22 ill ill JJ cord-275349-b35pt3mo 20 23 patients patient NNS cord-275349-b35pt3mo 20 24 with with IN cord-275349-b35pt3mo 20 25 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 20 26 treated treat VBN cord-275349-b35pt3mo 20 27 with with IN cord-275349-b35pt3mo 20 28 baricitinib baricitinib NNP cord-275349-b35pt3mo 20 29 and and CC cord-275349-b35pt3mo 20 30 hydroxychloroquine hydroxychloroquine NN cord-275349-b35pt3mo 20 31 . . . cord-275349-b35pt3mo 21 1 This this DT cord-275349-b35pt3mo 21 2 therapy therapy NN cord-275349-b35pt3mo 21 3 was be VBD cord-275349-b35pt3mo 21 4 associated associate VBN cord-275349-b35pt3mo 21 5 with with IN cord-275349-b35pt3mo 21 6 a a DT cord-275349-b35pt3mo 21 7 reduction reduction NN cord-275349-b35pt3mo 21 8 in in IN cord-275349-b35pt3mo 21 9 inflammatory inflammatory JJ cord-275349-b35pt3mo 21 10 markers marker NNS cord-275349-b35pt3mo 21 11 including include VBG cord-275349-b35pt3mo 21 12 fever fever NN cord-275349-b35pt3mo 21 13 , , , cord-275349-b35pt3mo 21 14 C C NNP cord-275349-b35pt3mo 21 15 reactive reactive JJ cord-275349-b35pt3mo 21 16 protein protein NN cord-275349-b35pt3mo 21 17 ( ( -LRB- cord-275349-b35pt3mo 21 18 CRP CRP NNP cord-275349-b35pt3mo 21 19 ) ) -RRB- cord-275349-b35pt3mo 21 20 , , , cord-275349-b35pt3mo 21 21 improvement improvement NN cord-275349-b35pt3mo 21 22 of of IN cord-275349-b35pt3mo 21 23 oxygen oxygen NN cord-275349-b35pt3mo 21 24 requirements requirement NNS cord-275349-b35pt3mo 21 25 , , , cord-275349-b35pt3mo 21 26 and and CC cord-275349-b35pt3mo 21 27 recovery recovery NN cord-275349-b35pt3mo 21 28 in in IN cord-275349-b35pt3mo 21 29 12 12 CD cord-275349-b35pt3mo 21 30 of of IN cord-275349-b35pt3mo 21 31 the the DT cord-275349-b35pt3mo 21 32 15 15 CD cord-275349-b35pt3mo 21 33 ( ( -LRB- cord-275349-b35pt3mo 21 34 80 80 CD cord-275349-b35pt3mo 21 35 % % NN cord-275349-b35pt3mo 21 36 ) ) -RRB- cord-275349-b35pt3mo 21 37 patients patient NNS cord-275349-b35pt3mo 21 38 studied study VBD cord-275349-b35pt3mo 21 39 . . . cord-275349-b35pt3mo 22 1 Although although IN cord-275349-b35pt3mo 22 2 it -PRON- PRP cord-275349-b35pt3mo 22 3 is be VBZ cord-275349-b35pt3mo 22 4 possible possible JJ cord-275349-b35pt3mo 22 5 that that IN cord-275349-b35pt3mo 22 6 the the DT cord-275349-b35pt3mo 22 7 antiviral antiviral JJ cord-275349-b35pt3mo 22 8 and and CC cord-275349-b35pt3mo 22 9 anti anti JJ cord-275349-b35pt3mo 22 10 - - JJ cord-275349-b35pt3mo 22 11 inflammatory inflammatory JJ cord-275349-b35pt3mo 22 12 effects effect NNS cord-275349-b35pt3mo 22 13 of of IN cord-275349-b35pt3mo 22 14 hydroxychloroquine hydroxychloroquine NN cord-275349-b35pt3mo 22 15 contributed contribute VBD cord-275349-b35pt3mo 22 16 to to IN cord-275349-b35pt3mo 22 17 this this DT cord-275349-b35pt3mo 22 18 positive positive JJ cord-275349-b35pt3mo 22 19 outcome outcome NN cord-275349-b35pt3mo 22 20 , , , cord-275349-b35pt3mo 22 21 this this DT cord-275349-b35pt3mo 22 22 would would MD cord-275349-b35pt3mo 22 23 seem seem VB cord-275349-b35pt3mo 22 24 unlikely unlikely JJ cord-275349-b35pt3mo 22 25 according accord VBG cord-275349-b35pt3mo 22 26 to to IN cord-275349-b35pt3mo 22 27 the the DT cord-275349-b35pt3mo 22 28 recently recently RB cord-275349-b35pt3mo 22 29 reported report VBN cord-275349-b35pt3mo 22 30 National National NNP cord-275349-b35pt3mo 22 31 Institutes Institutes NNPS cord-275349-b35pt3mo 22 32 of of IN cord-275349-b35pt3mo 22 33 Health Health NNP cord-275349-b35pt3mo 22 34 ( ( -LRB- cord-275349-b35pt3mo 22 35 NIH NIH NNP cord-275349-b35pt3mo 22 36 ) ) -RRB- cord-275349-b35pt3mo 22 37 randomized randomized JJ cord-275349-b35pt3mo 22 38 trials trial NNS cord-275349-b35pt3mo 22 39 ) ) -RRB- cord-275349-b35pt3mo 22 40 [ [ -LRB- cord-275349-b35pt3mo 22 41 5 5 CD cord-275349-b35pt3mo 22 42 ] ] -RRB- cord-275349-b35pt3mo 22 43 , , , cord-275349-b35pt3mo 22 44 among among IN cord-275349-b35pt3mo 22 45 many many JJ cord-275349-b35pt3mo 22 46 other other JJ cord-275349-b35pt3mo 22 47 studies study NNS cord-275349-b35pt3mo 22 48 . . . cord-275349-b35pt3mo 23 1 This this DT cord-275349-b35pt3mo 23 2 new new JJ cord-275349-b35pt3mo 23 3 paper paper NN cord-275349-b35pt3mo 23 4 in in IN cord-275349-b35pt3mo 23 5 the the DT cord-275349-b35pt3mo 23 6 journal journal NN cord-275349-b35pt3mo 23 7 extends extend VBZ cord-275349-b35pt3mo 23 8 the the DT cord-275349-b35pt3mo 23 9 previous previous JJ cord-275349-b35pt3mo 23 10 published publish VBN cord-275349-b35pt3mo 23 11 reports report NNS cord-275349-b35pt3mo 23 12 of of IN cord-275349-b35pt3mo 23 13 baricitinib baricitinib NN cord-275349-b35pt3mo 23 14 treatment treatment NN cord-275349-b35pt3mo 23 15 in in IN cord-275349-b35pt3mo 23 16 mild mild JJ cord-275349-b35pt3mo 23 17 - - HYPH cord-275349-b35pt3mo 23 18 tomoderate tomoderate NN cord-275349-b35pt3mo 23 19 COVID19 covid19 NN cord-275349-b35pt3mo 23 20 patients patient NNS cord-275349-b35pt3mo 23 21 and and CC cord-275349-b35pt3mo 23 22 provides provide VBZ cord-275349-b35pt3mo 23 23 further further JJ cord-275349-b35pt3mo 23 24 evidence evidence NN cord-275349-b35pt3mo 23 25 that that IN cord-275349-b35pt3mo 23 26 baricitinib baricitinib NN cord-275349-b35pt3mo 23 27 could could MD cord-275349-b35pt3mo 23 28 be be VB cord-275349-b35pt3mo 23 29 a a DT cord-275349-b35pt3mo 23 30 potential potential JJ cord-275349-b35pt3mo 23 31 treatment treatment NN cord-275349-b35pt3mo 23 32 for for IN cord-275349-b35pt3mo 23 33 unwell unwell RB cord-275349-b35pt3mo 23 34 hospitalized hospitalize VBN cord-275349-b35pt3mo 23 35 patients patient NNS cord-275349-b35pt3mo 23 36 with with IN cord-275349-b35pt3mo 23 37 this this DT cord-275349-b35pt3mo 23 38 disease disease NN cord-275349-b35pt3mo 23 39 , , , cord-275349-b35pt3mo 23 40 independent independent JJ cord-275349-b35pt3mo 23 41 of of IN cord-275349-b35pt3mo 23 42 severity severity NN cord-275349-b35pt3mo 23 43 . . . cord-275349-b35pt3mo 24 1 Indeed indeed RB cord-275349-b35pt3mo 24 2 , , , cord-275349-b35pt3mo 24 3 in in IN cord-275349-b35pt3mo 24 4 mild mild NN cord-275349-b35pt3mo 24 5 - - HYPH cord-275349-b35pt3mo 24 6 to to IN cord-275349-b35pt3mo 24 7 - - HYPH cord-275349-b35pt3mo 24 8 moderate moderate JJ cord-275349-b35pt3mo 24 9 patients patient NNS cord-275349-b35pt3mo 24 10 , , , cord-275349-b35pt3mo 24 11 baricitinib baricitinib NNP cord-275349-b35pt3mo 24 12 therapy therapy NN cord-275349-b35pt3mo 24 13 was be VBD cord-275349-b35pt3mo 24 14 also also RB cord-275349-b35pt3mo 24 15 associated associate VBN cord-275349-b35pt3mo 24 16 with with IN cord-275349-b35pt3mo 24 17 a a DT cord-275349-b35pt3mo 24 18 reduction reduction NN cord-275349-b35pt3mo 24 19 in in IN cord-275349-b35pt3mo 24 20 the the DT cord-275349-b35pt3mo 24 21 requirement requirement NN cord-275349-b35pt3mo 24 22 for for IN cord-275349-b35pt3mo 24 23 intensive intensive JJ cord-275349-b35pt3mo 24 24 care care NN cord-275349-b35pt3mo 24 25 unit unit NN cord-275349-b35pt3mo 24 26 ( ( -LRB- cord-275349-b35pt3mo 24 27 ICU ICU NNP cord-275349-b35pt3mo 24 28 ) ) -RRB- cord-275349-b35pt3mo 24 29 care care NN cord-275349-b35pt3mo 24 30 when when WRB cord-275349-b35pt3mo 24 31 compared compare VBN cord-275349-b35pt3mo 24 32 with with IN cord-275349-b35pt3mo 24 33 matched match VBN cord-275349-b35pt3mo 24 34 case case NN cord-275349-b35pt3mo 24 35 controls control NNS cord-275349-b35pt3mo 24 36 [ [ -LRB- cord-275349-b35pt3mo 24 37 6 6 CD cord-275349-b35pt3mo 24 38 , , , cord-275349-b35pt3mo 24 39 7 7 CD cord-275349-b35pt3mo 24 40 ] ] -RRB- cord-275349-b35pt3mo 24 41 . . . cord-275349-b35pt3mo 25 1 In in IN cord-275349-b35pt3mo 25 2 each each DT cord-275349-b35pt3mo 25 3 series series NN cord-275349-b35pt3mo 25 4 baricitinib baricitinib NN cord-275349-b35pt3mo 25 5 treatment treatment NN cord-275349-b35pt3mo 25 6 has have VBZ cord-275349-b35pt3mo 25 7 been be VBN cord-275349-b35pt3mo 25 8 associated associate VBN cord-275349-b35pt3mo 25 9 with with IN cord-275349-b35pt3mo 25 10 a a DT cord-275349-b35pt3mo 25 11 reduction reduction NN cord-275349-b35pt3mo 25 12 in in IN cord-275349-b35pt3mo 25 13 inflammation inflammation NN cord-275349-b35pt3mo 25 14 and and CC cord-275349-b35pt3mo 25 15 recovery recovery NN cord-275349-b35pt3mo 25 16 from from IN cord-275349-b35pt3mo 25 17 the the DT cord-275349-b35pt3mo 25 18 disease disease NN cord-275349-b35pt3mo 25 19 in in IN cord-275349-b35pt3mo 25 20 the the DT cord-275349-b35pt3mo 25 21 vast vast JJ cord-275349-b35pt3mo 25 22 majority majority NN cord-275349-b35pt3mo 25 23 of of IN cord-275349-b35pt3mo 25 24 patients patient NNS cord-275349-b35pt3mo 25 25 , , , cord-275349-b35pt3mo 25 26 consistent consistent JJ cord-275349-b35pt3mo 25 27 with with IN cord-275349-b35pt3mo 25 28 the the DT cord-275349-b35pt3mo 25 29 present present JJ cord-275349-b35pt3mo 25 30 report report NN cord-275349-b35pt3mo 25 31 , , , cord-275349-b35pt3mo 25 32 but but CC cord-275349-b35pt3mo 25 33 we -PRON- PRP cord-275349-b35pt3mo 25 34 do do VBP cord-275349-b35pt3mo 25 35 not not RB cord-275349-b35pt3mo 25 36 know know VB cord-275349-b35pt3mo 25 37 if if IN cord-275349-b35pt3mo 25 38 this this DT cord-275349-b35pt3mo 25 39 is be VBZ cord-275349-b35pt3mo 25 40 simply simply RB cord-275349-b35pt3mo 25 41 an an DT cord-275349-b35pt3mo 25 42 association association NN cord-275349-b35pt3mo 25 43 or or CC cord-275349-b35pt3mo 25 44 represents represent VBZ cord-275349-b35pt3mo 25 45 a a DT cord-275349-b35pt3mo 25 46 causative causative JJ cord-275349-b35pt3mo 25 47 effect effect NN cord-275349-b35pt3mo 25 48 of of IN cord-275349-b35pt3mo 25 49 the the DT cord-275349-b35pt3mo 25 50 drug drug NN cord-275349-b35pt3mo 25 51 . . . cord-275349-b35pt3mo 26 1 In in IN cord-275349-b35pt3mo 26 2 this this DT cord-275349-b35pt3mo 26 3 new new JJ cord-275349-b35pt3mo 26 4 paper paper NN cord-275349-b35pt3mo 26 5 , , , cord-275349-b35pt3mo 26 6 3 3 CD cord-275349-b35pt3mo 26 7 patients patient NNS cord-275349-b35pt3mo 26 8 died die VBD cord-275349-b35pt3mo 26 9 , , , cord-275349-b35pt3mo 26 10 2 2 CD cord-275349-b35pt3mo 26 11 of of IN cord-275349-b35pt3mo 26 12 which which WDT cord-275349-b35pt3mo 26 13 had have VBD cord-275349-b35pt3mo 26 14 very very RB cord-275349-b35pt3mo 26 15 high high JJ cord-275349-b35pt3mo 26 16 plasma plasma NN cord-275349-b35pt3mo 26 17 IL-6 IL-6 NNP cord-275349-b35pt3mo 26 18 levels level NNS cord-275349-b35pt3mo 26 19 prior prior RB cord-275349-b35pt3mo 26 20 to to IN cord-275349-b35pt3mo 26 21 starting start VBG cord-275349-b35pt3mo 26 22 baricitinib baricitinib NNP cord-275349-b35pt3mo 26 23 therapy therapy NN cord-275349-b35pt3mo 26 24 consistent consistent JJ cord-275349-b35pt3mo 26 25 with with IN cord-275349-b35pt3mo 26 26 previous previous JJ cord-275349-b35pt3mo 26 27 data datum NNS cord-275349-b35pt3mo 26 28 that that WDT cord-275349-b35pt3mo 26 29 high high JJ cord-275349-b35pt3mo 26 30 IL-6 IL-6 NNP cord-275349-b35pt3mo 26 31 is be VBZ cord-275349-b35pt3mo 26 32 a a DT cord-275349-b35pt3mo 26 33 predictor predictor NN cord-275349-b35pt3mo 26 34 of of IN cord-275349-b35pt3mo 26 35 mortality mortality NN cord-275349-b35pt3mo 26 36 in in IN cord-275349-b35pt3mo 26 37 COVD19 covd19 NN cord-275349-b35pt3mo 26 38 infections infection NNS cord-275349-b35pt3mo 26 39 [ [ -LRB- cord-275349-b35pt3mo 26 40 8 8 CD cord-275349-b35pt3mo 26 41 , , , cord-275349-b35pt3mo 26 42 9 9 CD cord-275349-b35pt3mo 26 43 ] ] -RRB- cord-275349-b35pt3mo 26 44 . . . cord-275349-b35pt3mo 27 1 These these DT cord-275349-b35pt3mo 27 2 useful useful JJ cord-275349-b35pt3mo 27 3 results result NNS cord-275349-b35pt3mo 27 4 retrospectively retrospectively RB cord-275349-b35pt3mo 27 5 justified justify VBD cord-275349-b35pt3mo 27 6 the the DT cord-275349-b35pt3mo 27 7 testing testing NN cord-275349-b35pt3mo 27 8 of of IN cord-275349-b35pt3mo 27 9 the the DT cord-275349-b35pt3mo 27 10 anti anti JJ cord-275349-b35pt3mo 27 11 - - NNP cord-275349-b35pt3mo 27 12 IL6/ IL6/ NNP cord-275349-b35pt3mo 27 13 IL6R IL6R NNP cord-275349-b35pt3mo 27 14 antibodies antibody NNS cord-275349-b35pt3mo 28 1 Kevzara Kevzara NNP cord-275349-b35pt3mo 28 2 ( ( -LRB- cord-275349-b35pt3mo 28 3 sarilumab sarilumab NNP cord-275349-b35pt3mo 28 4 ) ) -RRB- cord-275349-b35pt3mo 28 5 and and CC cord-275349-b35pt3mo 28 6 Actemra Actemra NNP cord-275349-b35pt3mo 28 7 ( ( -LRB- cord-275349-b35pt3mo 28 8 tocilizumab tocilizumab NNP cord-275349-b35pt3mo 28 9 ) ) -RRB- cord-275349-b35pt3mo 28 10 in in IN cord-275349-b35pt3mo 28 11 severely severely RB cord-275349-b35pt3mo 28 12 unwell unwell JJ cord-275349-b35pt3mo 28 13 patients patient NNS cord-275349-b35pt3mo 28 14 , , , cord-275349-b35pt3mo 28 15 although although IN cord-275349-b35pt3mo 28 16 randomized randomized JJ cord-275349-b35pt3mo 28 17 studies study NNS cord-275349-b35pt3mo 28 18 are be VBP cord-275349-b35pt3mo 28 19 yet yet RB cord-275349-b35pt3mo 28 20 to to TO cord-275349-b35pt3mo 28 21 show show VB cord-275349-b35pt3mo 28 22 benefits benefit NNS cord-275349-b35pt3mo 28 23 . . . cord-275349-b35pt3mo 29 1 Baricitinib Baricitinib NNP cord-275349-b35pt3mo 29 2 treatment treatment NN cord-275349-b35pt3mo 29 3 over over IN cord-275349-b35pt3mo 29 4 prolonged prolong VBN cord-275349-b35pt3mo 29 5 periods period NNS cord-275349-b35pt3mo 29 6 in in IN cord-275349-b35pt3mo 29 7 RA RA NNP cord-275349-b35pt3mo 29 8 patients patient NNS cord-275349-b35pt3mo 29 9 has have VBZ cord-275349-b35pt3mo 29 10 been be VBN cord-275349-b35pt3mo 29 11 associated associate VBN cord-275349-b35pt3mo 29 12 with with IN cord-275349-b35pt3mo 29 13 increased increase VBN cord-275349-b35pt3mo 29 14 infections infection NNS cord-275349-b35pt3mo 29 15 and and CC cord-275349-b35pt3mo 29 16 thromboembolism thromboembolism NN cord-275349-b35pt3mo 29 17 , , , cord-275349-b35pt3mo 29 18 but but CC cord-275349-b35pt3mo 29 19 the the DT cord-275349-b35pt3mo 29 20 short short JJ cord-275349-b35pt3mo 29 21 duration duration NN cord-275349-b35pt3mo 29 22 of of IN cord-275349-b35pt3mo 29 23 treatment treatment NN cord-275349-b35pt3mo 29 24 in in IN cord-275349-b35pt3mo 29 25 COVID-19 covid-19 CD cord-275349-b35pt3mo 29 26 patients patient NNS cord-275349-b35pt3mo 29 27 may may MD cord-275349-b35pt3mo 29 28 mitigate mitigate VB cord-275349-b35pt3mo 29 29 against against IN cord-275349-b35pt3mo 29 30 such such JJ cord-275349-b35pt3mo 29 31 side side NN cord-275349-b35pt3mo 29 32 effects effect NNS cord-275349-b35pt3mo 29 33 . . . cord-275349-b35pt3mo 30 1 In in IN cord-275349-b35pt3mo 30 2 this this DT cord-275349-b35pt3mo 30 3 report report NN cord-275349-b35pt3mo 30 4 it -PRON- PRP cord-275349-b35pt3mo 30 5 is be VBZ cord-275349-b35pt3mo 30 6 difficult difficult JJ cord-275349-b35pt3mo 30 7 to to TO cord-275349-b35pt3mo 30 8 say say VB cord-275349-b35pt3mo 30 9 whether whether IN cord-275349-b35pt3mo 30 10 one one CD cord-275349-b35pt3mo 30 11 incident incident NN cord-275349-b35pt3mo 30 12 of of IN cord-275349-b35pt3mo 30 13 pulmonary pulmonary JJ cord-275349-b35pt3mo 30 14 embolism embolism NN cord-275349-b35pt3mo 30 15 and and CC cord-275349-b35pt3mo 30 16 methicillinresistant methicillinresistant JJ cord-275349-b35pt3mo 30 17 Staphylococcus Staphylococcus NNP cord-275349-b35pt3mo 30 18 aureus aureus NN cord-275349-b35pt3mo 30 19 ( ( -LRB- cord-275349-b35pt3mo 30 20 MRSA MRSA NNP cord-275349-b35pt3mo 30 21 ) ) -RRB- cord-275349-b35pt3mo 30 22 infection infection NN cord-275349-b35pt3mo 30 23 were be VBD cord-275349-b35pt3mo 30 24 due due JJ cord-275349-b35pt3mo 30 25 to to IN cord-275349-b35pt3mo 30 26 the the DT cord-275349-b35pt3mo 30 27 complications complication NNS cord-275349-b35pt3mo 30 28 of of IN cord-275349-b35pt3mo 30 29 COVID-19 covid-19 CD cord-275349-b35pt3mo 30 30 or or CC cord-275349-b35pt3mo 30 31 baricitinib baricitinib NNP cord-275349-b35pt3mo 30 32 , , , cord-275349-b35pt3mo 30 33 but but CC cord-275349-b35pt3mo 30 34 the the DT cord-275349-b35pt3mo 30 35 much much RB cord-275349-b35pt3mo 30 36 larger large JJR cord-275349-b35pt3mo 30 37 numbers number NNS cord-275349-b35pt3mo 30 38 of of IN cord-275349-b35pt3mo 30 39 patients patient NNS cord-275349-b35pt3mo 30 40 in in IN cord-275349-b35pt3mo 30 41 the the DT cord-275349-b35pt3mo 30 42 yet yet RB cord-275349-b35pt3mo 30 43 to to TO cord-275349-b35pt3mo 30 44 report report VB cord-275349-b35pt3mo 30 45 randomized randomized JJ cord-275349-b35pt3mo 30 46 studies study NNS cord-275349-b35pt3mo 30 47 should should MD cord-275349-b35pt3mo 30 48 clarify clarify VB cord-275349-b35pt3mo 30 49 this this DT cord-275349-b35pt3mo 30 50 . . . cord-275349-b35pt3mo 31 1 One one PRP cord-275349-b35pt3mo 31 2 would would MD cord-275349-b35pt3mo 31 3 be be VB cord-275349-b35pt3mo 31 4 advised advise VBN cord-275349-b35pt3mo 31 5 to to TO cord-275349-b35pt3mo 31 6 remain remain VB cord-275349-b35pt3mo 31 7 vigilant vigilant JJ cord-275349-b35pt3mo 31 8 of of IN cord-275349-b35pt3mo 31 9 such such JJ cord-275349-b35pt3mo 31 10 signals signal NNS cord-275349-b35pt3mo 31 11 reflecting reflect VBG cord-275349-b35pt3mo 31 12 thromboembolic thromboembolic NN cord-275349-b35pt3mo 31 13 or or CC cord-275349-b35pt3mo 31 14 infection infection NN cord-275349-b35pt3mo 31 15 risk risk NN cord-275349-b35pt3mo 31 16 in in IN cord-275349-b35pt3mo 31 17 randomized randomized JJ cord-275349-b35pt3mo 31 18 controlled controlled JJ cord-275349-b35pt3mo 31 19 trials trial NNS cord-275349-b35pt3mo 31 20 testing test VBG cord-275349-b35pt3mo 31 21 a a DT cord-275349-b35pt3mo 31 22 variety variety NN cord-275349-b35pt3mo 31 23 of of IN cord-275349-b35pt3mo 31 24 immunomodulatory immunomodulatory JJ cord-275349-b35pt3mo 31 25 therapies therapy NNS cord-275349-b35pt3mo 31 26 in in IN cord-275349-b35pt3mo 31 27 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 31 28 patients patient NNS cord-275349-b35pt3mo 31 29 , , , cord-275349-b35pt3mo 31 30 either either CC cord-275349-b35pt3mo 31 31 alone alone RB cord-275349-b35pt3mo 31 32 or or CC cord-275349-b35pt3mo 31 33 in in IN cord-275349-b35pt3mo 31 34 combination combination NN cord-275349-b35pt3mo 31 35 , , , cord-275349-b35pt3mo 31 36 especially especially RB cord-275349-b35pt3mo 31 37 in in IN cord-275349-b35pt3mo 31 38 view view NN cord-275349-b35pt3mo 31 39 of of IN cord-275349-b35pt3mo 31 40 associations association NNS cord-275349-b35pt3mo 31 41 between between IN cord-275349-b35pt3mo 31 42 clots clot NNS cord-275349-b35pt3mo 31 43 and and CC cord-275349-b35pt3mo 31 44 SARS SARS NNP cord-275349-b35pt3mo 31 45 - - HYPH cord-275349-b35pt3mo 31 46 CoV-2 CoV-2 NNP cord-275349-b35pt3mo 31 47 infection infection NN cord-275349-b35pt3mo 31 48 [ [ -LRB- cord-275349-b35pt3mo 31 49 10 10 CD cord-275349-b35pt3mo 31 50 ] ] -RRB- cord-275349-b35pt3mo 31 51 . . . cord-275349-b35pt3mo 32 1 Specifically specifically RB cord-275349-b35pt3mo 32 2 , , , cord-275349-b35pt3mo 32 3 severe severe JJ cord-275349-b35pt3mo 32 4 endothelial endothelial JJ cord-275349-b35pt3mo 32 5 injury injury NN cord-275349-b35pt3mo 32 6 associated associate VBN cord-275349-b35pt3mo 32 7 with with IN cord-275349-b35pt3mo 32 8 intracellular intracellular JJ cord-275349-b35pt3mo 32 9 SARS SARS NNP cord-275349-b35pt3mo 32 10 - - HYPH cord-275349-b35pt3mo 32 11 CoV-2 CoV-2 NNP cord-275349-b35pt3mo 32 12 virus virus NN cord-275349-b35pt3mo 32 13 and and CC cord-275349-b35pt3mo 32 14 disrupted disrupt VBD cord-275349-b35pt3mo 32 15 endothelial endothelial JJ cord-275349-b35pt3mo 32 16 cell cell NN cord-275349-b35pt3mo 32 17 membranes membrane NNS cord-275349-b35pt3mo 32 18 , , , cord-275349-b35pt3mo 32 19 widespread widespread JJ cord-275349-b35pt3mo 32 20 vascular vascular JJ cord-275349-b35pt3mo 32 21 thrombosis thrombosis NN cord-275349-b35pt3mo 32 22 with with IN cord-275349-b35pt3mo 32 23 microangiopathy microangiopathy NNP cord-275349-b35pt3mo 32 24 , , , cord-275349-b35pt3mo 32 25 and and CC cord-275349-b35pt3mo 32 26 occlusion occlusion NN cord-275349-b35pt3mo 32 27 of of IN cord-275349-b35pt3mo 32 28 alveolar alveolar JJ cord-275349-b35pt3mo 32 29 capillaries capillary NNS cord-275349-b35pt3mo 32 30 including include VBG cord-275349-b35pt3mo 32 31 significant significant JJ cord-275349-b35pt3mo 32 32 new new JJ cord-275349-b35pt3mo 32 33 vessel vessel NN cord-275349-b35pt3mo 32 34 growth growth NN cord-275349-b35pt3mo 32 35 through through IN cord-275349-b35pt3mo 32 36 a a DT cord-275349-b35pt3mo 32 37 mechanism mechanism NN cord-275349-b35pt3mo 32 38 of of IN cord-275349-b35pt3mo 32 39 intussusceptive intussusceptive JJ cord-275349-b35pt3mo 32 40 angiogenesis angiogenesis NN cord-275349-b35pt3mo 32 41 has have VBZ cord-275349-b35pt3mo 32 42 been be VBN cord-275349-b35pt3mo 32 43 described describe VBN cord-275349-b35pt3mo 32 44 [ [ -LRB- cord-275349-b35pt3mo 32 45 11 11 CD cord-275349-b35pt3mo 32 46 ] ] -RRB- cord-275349-b35pt3mo 32 47 . . . cord-275349-b35pt3mo 33 1 The the DT cord-275349-b35pt3mo 33 2 first first JJ cord-275349-b35pt3mo 33 3 report report NN cord-275349-b35pt3mo 33 4 of of IN cord-275349-b35pt3mo 33 5 a a DT cord-275349-b35pt3mo 33 6 significant significant JJ cord-275349-b35pt3mo 33 7 reduction reduction NN cord-275349-b35pt3mo 33 8 in in IN cord-275349-b35pt3mo 33 9 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 33 10 mortality mortality NN cord-275349-b35pt3mo 33 11 in in IN cord-275349-b35pt3mo 33 12 any any DT cord-275349-b35pt3mo 33 13 randomized randomized JJ cord-275349-b35pt3mo 33 14 study study NN cord-275349-b35pt3mo 33 15 recently recently RB cord-275349-b35pt3mo 33 16 came come VBD cord-275349-b35pt3mo 33 17 from from IN cord-275349-b35pt3mo 33 18 the the DT cord-275349-b35pt3mo 33 19 RECOVERY recovery NN cord-275349-b35pt3mo 33 20 trial trial NN cord-275349-b35pt3mo 33 21 in in IN cord-275349-b35pt3mo 33 22 the the DT cord-275349-b35pt3mo 33 23 United United NNP cord-275349-b35pt3mo 33 24 Kingdom Kingdom NNP cord-275349-b35pt3mo 33 25 showing show VBG cord-275349-b35pt3mo 33 26 that that DT cord-275349-b35pt3mo 33 27 low low JJ cord-275349-b35pt3mo 33 28 dose dose NN cord-275349-b35pt3mo 33 29 dexamethasone dexamethasone NN cord-275349-b35pt3mo 33 30 had have VBD cord-275349-b35pt3mo 33 31 a a DT cord-275349-b35pt3mo 33 32 significant significant JJ cord-275349-b35pt3mo 33 33 effect effect NN cord-275349-b35pt3mo 33 34 in in IN cord-275349-b35pt3mo 33 35 reducing reduce VBG cord-275349-b35pt3mo 33 36 mortality mortality NN cord-275349-b35pt3mo 33 37 when when WRB cord-275349-b35pt3mo 33 38 given give VBN cord-275349-b35pt3mo 33 39 with with IN cord-275349-b35pt3mo 33 40 standard standard NN cord-275349-b35pt3mo 33 41 of of IN cord-275349-b35pt3mo 33 42 care care NN cord-275349-b35pt3mo 33 43 ( ( -LRB- cord-275349-b35pt3mo 33 44 21.6 21.6 CD cord-275349-b35pt3mo 33 45 % % NN cord-275349-b35pt3mo 33 46 vs vs IN cord-275349-b35pt3mo 33 47 24.6 24.6 CD cord-275349-b35pt3mo 33 48 % % NN cord-275349-b35pt3mo 33 49 of of IN cord-275349-b35pt3mo 33 50 the the DT cord-275349-b35pt3mo 33 51 patients patient NNS cord-275349-b35pt3mo 33 52 dying die VBG cord-275349-b35pt3mo 33 53 within within IN cord-275349-b35pt3mo 33 54 28 28 CD cord-275349-b35pt3mo 33 55 days day NNS cord-275349-b35pt3mo 33 56 ) ) -RRB- cord-275349-b35pt3mo 34 1 [ [ -LRB- cord-275349-b35pt3mo 34 2 12 12 CD cord-275349-b35pt3mo 34 3 ] ] -RRB- cord-275349-b35pt3mo 34 4 ; ; : cord-275349-b35pt3mo 34 5 this this DT cord-275349-b35pt3mo 34 6 effect effect NN cord-275349-b35pt3mo 34 7 was be VBD cord-275349-b35pt3mo 34 8 greatest great JJS cord-275349-b35pt3mo 34 9 in in IN cord-275349-b35pt3mo 34 10 ventilated ventilate VBN cord-275349-b35pt3mo 34 11 patients patient NNS cord-275349-b35pt3mo 34 12 ( ( -LRB- cord-275349-b35pt3mo 34 13 a a DT cord-275349-b35pt3mo 34 14 30 30 CD cord-275349-b35pt3mo 34 15 % % NN cord-275349-b35pt3mo 34 16 reduction reduction NN cord-275349-b35pt3mo 34 17 in in IN cord-275349-b35pt3mo 34 18 mortality mortality NN cord-275349-b35pt3mo 34 19 ) ) -RRB- cord-275349-b35pt3mo 34 20 and and CC cord-275349-b35pt3mo 34 21 slightly slightly RB cord-275349-b35pt3mo 34 22 less less JJR cord-275349-b35pt3mo 34 23 in in IN cord-275349-b35pt3mo 34 24 those those DT cord-275349-b35pt3mo 34 25 provided provide VBN cord-275349-b35pt3mo 34 26 with with IN cord-275349-b35pt3mo 34 27 noninvasive noninvasive JJ cord-275349-b35pt3mo 34 28 supplemental supplemental JJ cord-275349-b35pt3mo 34 29 oxygen oxygen NN cord-275349-b35pt3mo 34 30 ( ( -LRB- cord-275349-b35pt3mo 34 31 a a DT cord-275349-b35pt3mo 34 32 20 20 CD cord-275349-b35pt3mo 34 33 % % NN cord-275349-b35pt3mo 34 34 reduction reduction NN cord-275349-b35pt3mo 34 35 ) ) -RRB- cord-275349-b35pt3mo 35 1 [ [ -LRB- cord-275349-b35pt3mo 35 2 12 12 CD cord-275349-b35pt3mo 35 3 ] ] -RRB- cord-275349-b35pt3mo 35 4 . . . cord-275349-b35pt3mo 36 1 It -PRON- PRP cord-275349-b35pt3mo 36 2 is be VBZ cord-275349-b35pt3mo 36 3 tempting tempt VBG cord-275349-b35pt3mo 36 4 to to TO cord-275349-b35pt3mo 36 5 speculate speculate VB cord-275349-b35pt3mo 36 6 that that IN cord-275349-b35pt3mo 36 7 a a DT cord-275349-b35pt3mo 36 8 similar similar JJ cord-275349-b35pt3mo 36 9 or or CC cord-275349-b35pt3mo 36 10 greater great JJR cord-275349-b35pt3mo 36 11 reduction reduction NN cord-275349-b35pt3mo 36 12 in in IN cord-275349-b35pt3mo 36 13 mortality mortality NN cord-275349-b35pt3mo 36 14 could could MD cord-275349-b35pt3mo 36 15 be be VB cord-275349-b35pt3mo 36 16 expected expect VBN cord-275349-b35pt3mo 36 17 with with IN cord-275349-b35pt3mo 36 18 baricitinib baricitinib NN cord-275349-b35pt3mo 36 19 in in IN cord-275349-b35pt3mo 36 20 randomized randomized JJ cord-275349-b35pt3mo 36 21 trials trial NNS cord-275349-b35pt3mo 36 22 , , , cord-275349-b35pt3mo 36 23 especially especially RB cord-275349-b35pt3mo 36 24 because because IN cord-275349-b35pt3mo 36 25 baricitinib baricitinib NNP cord-275349-b35pt3mo 36 26 is be VBZ cord-275349-b35pt3mo 36 27 now now RB cord-275349-b35pt3mo 36 28 reported report VBN cord-275349-b35pt3mo 36 29 to to TO cord-275349-b35pt3mo 36 30 be be VB cord-275349-b35pt3mo 36 31 associated associate VBN cord-275349-b35pt3mo 36 32 with with IN cord-275349-b35pt3mo 36 33 recovery recovery NN cord-275349-b35pt3mo 36 34 from from IN cord-275349-b35pt3mo 36 35 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 36 36 in in IN cord-275349-b35pt3mo 36 37 different different JJ cord-275349-b35pt3mo 36 38 series series NN cord-275349-b35pt3mo 36 39 of of IN cord-275349-b35pt3mo 36 40 patients patient NNS cord-275349-b35pt3mo 36 41 . . . cord-275349-b35pt3mo 37 1 It -PRON- PRP cord-275349-b35pt3mo 37 2 may may MD cord-275349-b35pt3mo 37 3 even even RB cord-275349-b35pt3mo 37 4 be be VB cord-275349-b35pt3mo 37 5 possible possible JJ cord-275349-b35pt3mo 37 6 to to TO cord-275349-b35pt3mo 37 7 combine combine VB cord-275349-b35pt3mo 37 8 the the DT cord-275349-b35pt3mo 37 9 baricitinib baricitinib NN cord-275349-b35pt3mo 37 10 with with IN cord-275349-b35pt3mo 37 11 dexamethasone dexamethasone NN cord-275349-b35pt3mo 37 12 , , , cord-275349-b35pt3mo 37 13 at at IN cord-275349-b35pt3mo 37 14 least least JJS cord-275349-b35pt3mo 37 15 in in IN cord-275349-b35pt3mo 37 16 critically critically RB cord-275349-b35pt3mo 37 17 ill ill JJ cord-275349-b35pt3mo 37 18 patients patient NNS cord-275349-b35pt3mo 37 19 , , , cord-275349-b35pt3mo 37 20 although although IN cord-275349-b35pt3mo 37 21 once once RB cord-275349-b35pt3mo 37 22 again again RB cord-275349-b35pt3mo 37 23 it -PRON- PRP cord-275349-b35pt3mo 37 24 would would MD cord-275349-b35pt3mo 37 25 of of IN cord-275349-b35pt3mo 37 26 course course NN cord-275349-b35pt3mo 37 27 be be VB cord-275349-b35pt3mo 37 28 important important JJ cord-275349-b35pt3mo 37 29 to to TO cord-275349-b35pt3mo 37 30 assess assess VB cord-275349-b35pt3mo 37 31 the the DT cord-275349-b35pt3mo 37 32 risk risk NN cord-275349-b35pt3mo 37 33 of of IN cord-275349-b35pt3mo 37 34 infection infection NN cord-275349-b35pt3mo 37 35 when when WRB cord-275349-b35pt3mo 37 36 administering administer VBG cord-275349-b35pt3mo 37 37 these these DT cord-275349-b35pt3mo 37 38 2 2 CD cord-275349-b35pt3mo 37 39 potent potent JJ cord-275349-b35pt3mo 37 40 anti anti JJ cord-275349-b35pt3mo 37 41 - - JJ cord-275349-b35pt3mo 37 42 inflammatory inflammatory JJ cord-275349-b35pt3mo 37 43 agents agent NNS cord-275349-b35pt3mo 37 44 together together RB cord-275349-b35pt3mo 37 45 . . . cord-275349-b35pt3mo 38 1 As as IN cord-275349-b35pt3mo 38 2 acknowledged acknowledge VBN cord-275349-b35pt3mo 38 3 by by IN cord-275349-b35pt3mo 38 4 Titanji Titanji NNP cord-275349-b35pt3mo 38 5 et et NNP cord-275349-b35pt3mo 38 6 al al NNP cord-275349-b35pt3mo 38 7 , , , cord-275349-b35pt3mo 38 8 and and CC cord-275349-b35pt3mo 38 9 reiterated reiterate VBN cord-275349-b35pt3mo 38 10 by by IN cord-275349-b35pt3mo 38 11 us -PRON- PRP cord-275349-b35pt3mo 38 12 , , , cord-275349-b35pt3mo 38 13 randomized randomized JJ cord-275349-b35pt3mo 38 14 trials trial NNS cord-275349-b35pt3mo 38 15 are be VBP cord-275349-b35pt3mo 38 16 required require VBN cord-275349-b35pt3mo 38 17 for for IN cord-275349-b35pt3mo 38 18 us -PRON- PRP cord-275349-b35pt3mo 38 19 to to TO cord-275349-b35pt3mo 38 20 be be VB cord-275349-b35pt3mo 38 21 certain certain JJ cord-275349-b35pt3mo 38 22 if if IN cord-275349-b35pt3mo 38 23 baricitinib baricitinib NNP cord-275349-b35pt3mo 38 24 is be VBZ cord-275349-b35pt3mo 38 25 an an DT cord-275349-b35pt3mo 38 26 effective effective JJ cord-275349-b35pt3mo 38 27 and and CC cord-275349-b35pt3mo 38 28 safe safe JJ cord-275349-b35pt3mo 38 29 therapy therapy NN cord-275349-b35pt3mo 38 30 for for IN cord-275349-b35pt3mo 38 31 COVID-19 covid-19 JJ cord-275349-b35pt3mo 38 32 patients patient NNS cord-275349-b35pt3mo 38 33 [ [ -LRB- cord-275349-b35pt3mo 38 34 3 3 CD cord-275349-b35pt3mo 38 35 ] ] -RRB- cord-275349-b35pt3mo 38 36 . . . cord-275349-b35pt3mo 39 1 This this DT cord-275349-b35pt3mo 39 2 report report NN cord-275349-b35pt3mo 39 3 , , , cord-275349-b35pt3mo 39 4 and and CC cord-275349-b35pt3mo 39 5 others other NNS cord-275349-b35pt3mo 39 6 like like IN cord-275349-b35pt3mo 39 7 it -PRON- PRP cord-275349-b35pt3mo 39 8 , , , cord-275349-b35pt3mo 39 9 have have VBP cord-275349-b35pt3mo 39 10 supported support VBN cord-275349-b35pt3mo 39 11 the the DT cord-275349-b35pt3mo 39 12 selection selection NN cord-275349-b35pt3mo 39 13 of of IN cord-275349-b35pt3mo 39 14 baricitinib baricitinib NN cord-275349-b35pt3mo 39 15 in in IN cord-275349-b35pt3mo 39 16 a a DT cord-275349-b35pt3mo 39 17 number number NN cord-275349-b35pt3mo 39 18 of of IN cord-275349-b35pt3mo 39 19 studies study NNS cord-275349-b35pt3mo 39 20 including include VBG cord-275349-b35pt3mo 39 21 the the DT cord-275349-b35pt3mo 39 22 ACTT2 actt2 RB cord-275349-b35pt3mo 39 23 randomized randomized JJ cord-275349-b35pt3mo 39 24 trial trial NN cord-275349-b35pt3mo 39 25 , , , cord-275349-b35pt3mo 39 26 where where WRB cord-275349-b35pt3mo 39 27 it -PRON- PRP cord-275349-b35pt3mo 39 28 is be VBZ cord-275349-b35pt3mo 39 29 being be VBG cord-275349-b35pt3mo 39 30 tested test VBN cord-275349-b35pt3mo 39 31 in in IN cord-275349-b35pt3mo 39 32 combination combination NN cord-275349-b35pt3mo 39 33 with with IN cord-275349-b35pt3mo 39 34 remdesivir remdesivir NNP cord-275349-b35pt3mo 39 35 , , , cord-275349-b35pt3mo 39 36 and and CC cord-275349-b35pt3mo 39 37 a a DT cord-275349-b35pt3mo 39 38 further further JJ cord-275349-b35pt3mo 39 39 placebocontrolled placebocontrolled JJ cord-275349-b35pt3mo 39 40 phase phase NN cord-275349-b35pt3mo 39 41 3 3 CD cord-275349-b35pt3mo 39 42 trial trial NN cord-275349-b35pt3mo 39 43 recently recently RB cord-275349-b35pt3mo 39 44 commenced commence VBD cord-275349-b35pt3mo 39 45 . . . cord-275349-b35pt3mo 40 1 It -PRON- PRP cord-275349-b35pt3mo 40 2 is be VBZ cord-275349-b35pt3mo 40 3 anticipated anticipate VBN cord-275349-b35pt3mo 40 4 that that IN cord-275349-b35pt3mo 40 5 these these DT cord-275349-b35pt3mo 40 6 trials trial NNS cord-275349-b35pt3mo 40 7 should should MD cord-275349-b35pt3mo 40 8 provide provide VB cord-275349-b35pt3mo 40 9 a a DT cord-275349-b35pt3mo 40 10 robust robust JJ cord-275349-b35pt3mo 40 11 estimate estimate NN cord-275349-b35pt3mo 40 12 of of IN cord-275349-b35pt3mo 40 13 the the DT cord-275349-b35pt3mo 40 14 efficacy efficacy NN cord-275349-b35pt3mo 40 15 of of IN cord-275349-b35pt3mo 40 16 baricitinib baricitinib NNP cord-275349-b35pt3mo 40 17 in in IN cord-275349-b35pt3mo 40 18 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 40 19 and and CC cord-275349-b35pt3mo 40 20 would would MD cord-275349-b35pt3mo 40 21 be be VB cord-275349-b35pt3mo 40 22 complementary complementary JJ cord-275349-b35pt3mo 40 23 to to IN cord-275349-b35pt3mo 40 24 each each DT cord-275349-b35pt3mo 40 25 other other JJ cord-275349-b35pt3mo 40 26 . . . cord-275349-b35pt3mo 41 1 These these DT cord-275349-b35pt3mo 41 2 initial initial JJ cord-275349-b35pt3mo 41 3 case case NN cord-275349-b35pt3mo 41 4 series series NN cord-275349-b35pt3mo 41 5 warrant warrant VBP cord-275349-b35pt3mo 41 6 further further JJ cord-275349-b35pt3mo 41 7 confirmation confirmation NN cord-275349-b35pt3mo 41 8 from from IN cord-275349-b35pt3mo 41 9 the the DT cord-275349-b35pt3mo 41 10 ongoing ongoing JJ cord-275349-b35pt3mo 41 11 larger large JJR cord-275349-b35pt3mo 41 12 , , , cord-275349-b35pt3mo 41 13 randomized randomized JJ cord-275349-b35pt3mo 41 14 and and CC cord-275349-b35pt3mo 41 15 controlled control VBN cord-275349-b35pt3mo 41 16 trials trial NNS cord-275349-b35pt3mo 41 17 . . . cord-275349-b35pt3mo 42 1 Thus thus RB cord-275349-b35pt3mo 42 2 far far RB cord-275349-b35pt3mo 42 3 , , , cord-275349-b35pt3mo 42 4 these these DT cord-275349-b35pt3mo 42 5 data datum NNS cord-275349-b35pt3mo 42 6 sets set NNS cord-275349-b35pt3mo 42 7 also also RB cord-275349-b35pt3mo 42 8 validate validate VBP cord-275349-b35pt3mo 42 9 use use NN cord-275349-b35pt3mo 42 10 of of IN cord-275349-b35pt3mo 42 11 artificial artificial JJ cord-275349-b35pt3mo 42 12 intelligence intelligence NN cord-275349-b35pt3mo 42 13 at at IN cord-275349-b35pt3mo 42 14 a a DT cord-275349-b35pt3mo 42 15 time time NN cord-275349-b35pt3mo 42 16 of of IN cord-275349-b35pt3mo 42 17 a a DT cord-275349-b35pt3mo 42 18 biomedical biomedical JJ cord-275349-b35pt3mo 42 19 crisis crisis NN cord-275349-b35pt3mo 42 20 , , , cord-275349-b35pt3mo 42 21 to to TO cord-275349-b35pt3mo 42 22 help help VB cord-275349-b35pt3mo 42 23 speed speed VB cord-275349-b35pt3mo 42 24 drug drug NN cord-275349-b35pt3mo 42 25 development development NN cord-275349-b35pt3mo 42 26 . . . cord-275349-b35pt3mo 43 1 The the DT cord-275349-b35pt3mo 43 2 use use NN cord-275349-b35pt3mo 43 3 of of IN cord-275349-b35pt3mo 43 4 an an DT cord-275349-b35pt3mo 43 5 oral oral JJ cord-275349-b35pt3mo 43 6 medicine medicine NN cord-275349-b35pt3mo 43 7 taken take VBN cord-275349-b35pt3mo 43 8 once once RB cord-275349-b35pt3mo 43 9 daily daily RB cord-275349-b35pt3mo 43 10 for for IN cord-275349-b35pt3mo 43 11 a a DT cord-275349-b35pt3mo 43 12 short short JJ cord-275349-b35pt3mo 43 13 duration duration NN cord-275349-b35pt3mo 43 14 should should MD cord-275349-b35pt3mo 43 15 also also RB cord-275349-b35pt3mo 43 16 lend lend VB cord-275349-b35pt3mo 43 17 itself -PRON- PRP cord-275349-b35pt3mo 43 18 to to IN cord-275349-b35pt3mo 43 19 low low JJ cord-275349-b35pt3mo 43 20 - - HYPH cord-275349-b35pt3mo 43 21 and and CC cord-275349-b35pt3mo 43 22 middle middle JJ cord-275349-b35pt3mo 43 23 - - HYPH cord-275349-b35pt3mo 43 24 income income NN cord-275349-b35pt3mo 43 25 countries country NNS cord-275349-b35pt3mo 43 26 . . . cord-275349-b35pt3mo 44 1 Note note VB cord-275349-b35pt3mo 44 2 Potential potential JJ cord-275349-b35pt3mo 44 3 conflicts conflict NNS cord-275349-b35pt3mo 44 4 of of IN cord-275349-b35pt3mo 44 5 interest interest NN cord-275349-b35pt3mo 44 6 . . . cord-275349-b35pt3mo 45 1 P. P. NNP cord-275349-b35pt3mo 45 2 J. J. NNP cord-275349-b35pt3mo 45 3 R. R. NNP cord-275349-b35pt3mo 45 4 is be VBZ cord-275349-b35pt3mo 45 5 an an DT cord-275349-b35pt3mo 45 6 employee employee NN cord-275349-b35pt3mo 45 7 of of IN cord-275349-b35pt3mo 45 8 BenevolentAI benevolentai NN cord-275349-b35pt3mo 45 9 and and CC cord-275349-b35pt3mo 45 10 has have VBZ cord-275349-b35pt3mo 45 11 received receive VBN cord-275349-b35pt3mo 45 12 honoraria honorarium NNS cord-275349-b35pt3mo 45 13 for for IN cord-275349-b35pt3mo 45 14 giving give VBG cord-275349-b35pt3mo 45 15 a a DT cord-275349-b35pt3mo 45 16 lecture lecture NN cord-275349-b35pt3mo 45 17 to to IN cord-275349-b35pt3mo 45 18 Lilly Lilly NNP cord-275349-b35pt3mo 45 19 with with IN cord-275349-b35pt3mo 45 20 J. J. NNP cord-275349-b35pt3mo 45 21 S. S. NNP cord-275349-b35pt3mo 46 1 And and CC cord-275349-b35pt3mo 46 2 J. J. NNP cord-275349-b35pt3mo 46 3 S. S. NNP cord-275349-b35pt3mo 46 4 has have VBZ cord-275349-b35pt3mo 46 5 sat sit VBN cord-275349-b35pt3mo 46 6 on on IN cord-275349-b35pt3mo 46 7 SABs sab NNS cord-275349-b35pt3mo 46 8 for for IN cord-275349-b35pt3mo 46 9 Vaccitech Vaccitech NNP cord-275349-b35pt3mo 46 10 , , , cord-275349-b35pt3mo 46 11 Heat Heat NNP cord-275349-b35pt3mo 46 12 Biologics Biologics NNPS cord-275349-b35pt3mo 46 13 , , , cord-275349-b35pt3mo 46 14 Eli Eli NNP cord-275349-b35pt3mo 46 15 Lilly Lilly NNP cord-275349-b35pt3mo 46 16 , , , cord-275349-b35pt3mo 46 17 Replete replete JJ cord-275349-b35pt3mo 46 18 , , , cord-275349-b35pt3mo 46 19 Alveo Alveo NNP cord-275349-b35pt3mo 46 20 , , , cord-275349-b35pt3mo 46 21 Certis Certis NNP cord-275349-b35pt3mo 46 22 Oncology Oncology NNP cord-275349-b35pt3mo 46 23 Solutions Solutions NNPS cord-275349-b35pt3mo 46 24 , , , cord-275349-b35pt3mo 46 25 Greenmantle Greenmantle NNP cord-275349-b35pt3mo 46 26 and and CC cord-275349-b35pt3mo 46 27 BenevolentAI benevolentai NN cord-275349-b35pt3mo 46 28 , , , cord-275349-b35pt3mo 46 29 has have VBZ cord-275349-b35pt3mo 46 30 consulted consult VBN cord-275349-b35pt3mo 46 31 with with IN cord-275349-b35pt3mo 46 32 Lansdowne Lansdowne NNP cord-275349-b35pt3mo 46 33 partners partner NNS cord-275349-b35pt3mo 46 34 and and CC cord-275349-b35pt3mo 46 35 Vitruvian vitruvian JJ cord-275349-b35pt3mo 46 36 . . . cord-275349-b35pt3mo 47 1 He -PRON- PRP cord-275349-b35pt3mo 47 2 sits sit VBZ cord-275349-b35pt3mo 47 3 on on IN cord-275349-b35pt3mo 47 4 the the DT cord-275349-b35pt3mo 47 5 Board Board NNP cord-275349-b35pt3mo 47 6 of of IN cord-275349-b35pt3mo 47 7 Directors Directors NNPS cord-275349-b35pt3mo 47 8 for for IN cord-275349-b35pt3mo 47 9 BB BB NNP cord-275349-b35pt3mo 47 10 Biotech Biotech NNP cord-275349-b35pt3mo 47 11 Healthcare Healthcare NNP cord-275349-b35pt3mo 47 12 Trust Trust NNP cord-275349-b35pt3mo 47 13 . . . cord-275349-b35pt3mo 48 1 H.-J. H.-J. NNP cord-275349-b35pt3mo 49 1 L. L. NNP cord-275349-b35pt3mo 49 2 has have VBZ cord-275349-b35pt3mo 49 3 no no DT cord-275349-b35pt3mo 49 4 reported report VBN cord-275349-b35pt3mo 49 5 conflicts conflict NNS cord-275349-b35pt3mo 49 6 . . . cord-275349-b35pt3mo 50 1 All all DT cord-275349-b35pt3mo 50 2 authors author NNS cord-275349-b35pt3mo 50 3 have have VBP cord-275349-b35pt3mo 50 4 submitted submit VBN cord-275349-b35pt3mo 50 5 the the DT cord-275349-b35pt3mo 50 6 ICMJE ICMJE NNP cord-275349-b35pt3mo 50 7 Form Form NNP cord-275349-b35pt3mo 50 8 for for IN cord-275349-b35pt3mo 50 9 Disclosure Disclosure NNP cord-275349-b35pt3mo 50 10 of of IN cord-275349-b35pt3mo 50 11 Potential potential JJ cord-275349-b35pt3mo 50 12 Conflicts conflict NNS cord-275349-b35pt3mo 50 13 of of IN cord-275349-b35pt3mo 50 14 Interest interest NN cord-275349-b35pt3mo 50 15 . . . cord-275349-b35pt3mo 51 1 Conflicts conflict NNS cord-275349-b35pt3mo 51 2 that that WDT cord-275349-b35pt3mo 51 3 the the DT cord-275349-b35pt3mo 51 4 editors editor NNS cord-275349-b35pt3mo 51 5 consider consider VBP cord-275349-b35pt3mo 51 6 relevant relevant JJ cord-275349-b35pt3mo 51 7 to to IN cord-275349-b35pt3mo 51 8 the the DT cord-275349-b35pt3mo 51 9 content content NN cord-275349-b35pt3mo 51 10 of of IN cord-275349-b35pt3mo 51 11 the the DT cord-275349-b35pt3mo 51 12 manuscript manuscript NN cord-275349-b35pt3mo 51 13 have have VBP cord-275349-b35pt3mo 51 14 been be VBN cord-275349-b35pt3mo 51 15 disclosed disclose VBN cord-275349-b35pt3mo 51 16 . . . cord-275349-b35pt3mo 52 1 Baricitinib Baricitinib NNP cord-275349-b35pt3mo 52 2 versus versus IN cord-275349-b35pt3mo 52 3 placebo placebo NN cord-275349-b35pt3mo 52 4 or or CC cord-275349-b35pt3mo 52 5 adalimumab adalimumab NNS cord-275349-b35pt3mo 52 6 in in IN cord-275349-b35pt3mo 52 7 rheumatoid rheumatoid NN cord-275349-b35pt3mo 52 8 arthritis arthritis NN cord-275349-b35pt3mo 52 9 Baricitinib Baricitinib NNP cord-275349-b35pt3mo 52 10 as as IN cord-275349-b35pt3mo 52 11 potential potential JJ cord-275349-b35pt3mo 52 12 treatment treatment NN cord-275349-b35pt3mo 52 13 for for IN cord-275349-b35pt3mo 52 14 2019-nCoV 2019-ncov CD cord-275349-b35pt3mo 52 15 acute acute JJ cord-275349-b35pt3mo 52 16 respiratory respiratory JJ cord-275349-b35pt3mo 52 17 disease disease NN cord-275349-b35pt3mo 52 18 Mechanism Mechanism NNP cord-275349-b35pt3mo 52 19 of of IN cord-275349-b35pt3mo 52 20 baricitinib baricitinib NNP cord-275349-b35pt3mo 52 21 supports support VBZ cord-275349-b35pt3mo 52 22 artificial artificial JJ cord-275349-b35pt3mo 52 23 intelligencepredicted intelligencepredicte VBN cord-275349-b35pt3mo 52 24 testing testing NN cord-275349-b35pt3mo 52 25 in in IN cord-275349-b35pt3mo 52 26 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 52 27 patients patient NNS cord-275349-b35pt3mo 52 28 Efficacy Efficacy NNP cord-275349-b35pt3mo 52 29 and and CC cord-275349-b35pt3mo 52 30 safety safety NN cord-275349-b35pt3mo 52 31 of of IN cord-275349-b35pt3mo 52 32 baricitinib baricitinib NN cord-275349-b35pt3mo 52 33 in in IN cord-275349-b35pt3mo 52 34 Japanese japanese JJ cord-275349-b35pt3mo 52 35 patients patient NNS cord-275349-b35pt3mo 52 36 with with IN cord-275349-b35pt3mo 52 37 active active JJ cord-275349-b35pt3mo 52 38 rheumatoid rheumatoid NN cord-275349-b35pt3mo 52 39 arthritis arthritis NN cord-275349-b35pt3mo 52 40 receiving receive VBG cord-275349-b35pt3mo 52 41 background background NN cord-275349-b35pt3mo 52 42 methotrexate methotrexate NNP cord-275349-b35pt3mo 52 43 therapy therapy NN cord-275349-b35pt3mo 52 44 : : : cord-275349-b35pt3mo 53 1 a a DT cord-275349-b35pt3mo 53 2 12-week 12-week JJ cord-275349-b35pt3mo 53 3 , , , cord-275349-b35pt3mo 53 4 double double JJ cord-275349-b35pt3mo 53 5 - - HYPH cord-275349-b35pt3mo 53 6 blind blind JJ cord-275349-b35pt3mo 53 7 , , , cord-275349-b35pt3mo 53 8 randomized randomized JJ cord-275349-b35pt3mo 53 9 placebo placebo NN cord-275349-b35pt3mo 53 10 - - HYPH cord-275349-b35pt3mo 53 11 controlled control VBN cord-275349-b35pt3mo 53 12 study study NN cord-275349-b35pt3mo 53 13 Rapid Rapid NNP cord-275349-b35pt3mo 53 14 systematic systematic JJ cord-275349-b35pt3mo 53 15 review review NN cord-275349-b35pt3mo 53 16 on on IN cord-275349-b35pt3mo 53 17 clinical clinical JJ cord-275349-b35pt3mo 53 18 evidence evidence NN cord-275349-b35pt3mo 53 19 of of IN cord-275349-b35pt3mo 53 20 chloroquine chloroquine NNP cord-275349-b35pt3mo 53 21 and and CC cord-275349-b35pt3mo 53 22 hydroxychloroquine hydroxychloroquine NN cord-275349-b35pt3mo 53 23 in in IN cord-275349-b35pt3mo 53 24 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 53 25 critical critical JJ cord-275349-b35pt3mo 53 26 assessment assessment NN cord-275349-b35pt3mo 53 27 and and CC cord-275349-b35pt3mo 53 28 recommendation recommendation NN cord-275349-b35pt3mo 53 29 for for IN cord-275349-b35pt3mo 53 30 future future JJ cord-275349-b35pt3mo 53 31 clinical clinical JJ cord-275349-b35pt3mo 53 32 trials trial NNS cord-275349-b35pt3mo 53 33 Baricitinib Baricitinib NNP cord-275349-b35pt3mo 53 34 therapy therapy NN cord-275349-b35pt3mo 53 35 in in IN cord-275349-b35pt3mo 53 36 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 53 37 : : : cord-275349-b35pt3mo 53 38 a a DT cord-275349-b35pt3mo 53 39 pilot pilot NN cord-275349-b35pt3mo 53 40 study study NN cord-275349-b35pt3mo 53 41 on on IN cord-275349-b35pt3mo 53 42 safety safety NN cord-275349-b35pt3mo 53 43 and and CC cord-275349-b35pt3mo 53 44 clinical clinical JJ cord-275349-b35pt3mo 53 45 impact impact NN cord-275349-b35pt3mo 53 46 Retrospective Retrospective NNP cord-275349-b35pt3mo 53 47 , , , cord-275349-b35pt3mo 53 48 multicenter multicenter JJ cord-275349-b35pt3mo 53 49 study study NN cord-275349-b35pt3mo 53 50 on on IN cord-275349-b35pt3mo 53 51 the the DT cord-275349-b35pt3mo 53 52 impact impact NN cord-275349-b35pt3mo 53 53 of of IN cord-275349-b35pt3mo 53 54 baricitinib baricitinib NN cord-275349-b35pt3mo 53 55 in in IN cord-275349-b35pt3mo 53 56 COVID-19 covid-19 JJ cord-275349-b35pt3mo 53 57 moderate moderate JJ cord-275349-b35pt3mo 53 58 pneumonia pneumonia NN cord-275349-b35pt3mo 54 1 The the DT cord-275349-b35pt3mo 54 2 potential potential JJ cord-275349-b35pt3mo 54 3 role role NN cord-275349-b35pt3mo 54 4 of of IN cord-275349-b35pt3mo 54 5 IL-6 IL-6 NNP cord-275349-b35pt3mo 54 6 in in IN cord-275349-b35pt3mo 54 7 monitoring monitor VBG cord-275349-b35pt3mo 54 8 coronavirus coronavirus NN cord-275349-b35pt3mo 54 9 disease disease NN cord-275349-b35pt3mo 54 10 2019 2019 CD cord-275349-b35pt3mo 54 11 Clinical clinical JJ cord-275349-b35pt3mo 54 12 predictors predictor NNS cord-275349-b35pt3mo 54 13 of of IN cord-275349-b35pt3mo 54 14 mortality mortality NN cord-275349-b35pt3mo 54 15 due due IN cord-275349-b35pt3mo 54 16 to to IN cord-275349-b35pt3mo 54 17 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 54 18 based base VBN cord-275349-b35pt3mo 54 19 on on IN cord-275349-b35pt3mo 54 20 an an DT cord-275349-b35pt3mo 54 21 analysis analysis NN cord-275349-b35pt3mo 54 22 of of IN cord-275349-b35pt3mo 54 23 data datum NNS cord-275349-b35pt3mo 54 24 of of IN cord-275349-b35pt3mo 54 25 150 150 CD cord-275349-b35pt3mo 54 26 patients patient NNS cord-275349-b35pt3mo 54 27 from from IN cord-275349-b35pt3mo 54 28 Wuhan Wuhan NNP cord-275349-b35pt3mo 54 29 , , , cord-275349-b35pt3mo 54 30 China China NNP cord-275349-b35pt3mo 54 31 Immune Immune NNP cord-275349-b35pt3mo 54 32 mechanisms mechanism NNS cord-275349-b35pt3mo 54 33 of of IN cord-275349-b35pt3mo 54 34 pulmonary pulmonary JJ cord-275349-b35pt3mo 54 35 intravascular intravascular JJ cord-275349-b35pt3mo 54 36 coagulopathy coagulopathy NN cord-275349-b35pt3mo 54 37 in in IN cord-275349-b35pt3mo 54 38 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 54 39 pneumonia pneumonia NN cord-275349-b35pt3mo 54 40 Pulmonary Pulmonary NNP cord-275349-b35pt3mo 54 41 vascular vascular JJ cord-275349-b35pt3mo 54 42 endothelialitis endothelialitis NN cord-275349-b35pt3mo 54 43 , , , cord-275349-b35pt3mo 54 44 thrombosis thrombosis NN cord-275349-b35pt3mo 54 45 , , , cord-275349-b35pt3mo 54 46 and and CC cord-275349-b35pt3mo 54 47 angiogenesis angiogenesis NN cord-275349-b35pt3mo 54 48 in in IN cord-275349-b35pt3mo 54 49 Covid-19 Covid-19 NNP cord-275349-b35pt3mo 54 50 Effect Effect NNP cord-275349-b35pt3mo 54 51 of of IN cord-275349-b35pt3mo 54 52 dexamethasone dexamethasone NN cord-275349-b35pt3mo 54 53 in in IN cord-275349-b35pt3mo 54 54 hospitalized hospitalize VBN cord-275349-b35pt3mo 54 55 patients patient NNS cord-275349-b35pt3mo 54 56 with with IN cord-275349-b35pt3mo 54 57 COVID-19 COVID-19 NNP cord-275349-b35pt3mo 54 58 : : : cord-275349-b35pt3mo 54 59 preliminary preliminary JJ cord-275349-b35pt3mo 54 60 report report NN