id sid tid token lemma pos cord-015516-hx7ktq8j 1 1 key key NNP cord-015516-hx7ktq8j 1 2 : : : cord-015516-hx7ktq8j 1 3 cord-015516-hx7ktq8j cord-015516-hx7ktq8j : cord-015516-hx7ktq8j 1 4 authors author NNS cord-015516-hx7ktq8j 1 5 : : : cord-015516-hx7ktq8j 2 1 nan nan NNP cord-015516-hx7ktq8j 2 2 title title NN cord-015516-hx7ktq8j 2 3 : : : cord-015516-hx7ktq8j 3 1 In in IN cord-015516-hx7ktq8j 3 2 the the DT cord-015516-hx7ktq8j 3 3 Literature Literature NNP cord-015516-hx7ktq8j 3 4 date date NN cord-015516-hx7ktq8j 3 5 : : : cord-015516-hx7ktq8j 3 6 2005 2005 CD cord-015516-hx7ktq8j 3 7 - - SYM cord-015516-hx7ktq8j 3 8 10 10 CD cord-015516-hx7ktq8j 3 9 - - SYM cord-015516-hx7ktq8j 3 10 15 15 CD cord-015516-hx7ktq8j 3 11 journal journal NN cord-015516-hx7ktq8j 3 12 : : : cord-015516-hx7ktq8j 4 1 Clin Clin NNP cord-015516-hx7ktq8j 4 2 Infect infect VB cord-015516-hx7ktq8j 4 3 Dis Dis NNP cord-015516-hx7ktq8j 4 4 DOI doi NN cord-015516-hx7ktq8j 4 5 : : : cord-015516-hx7ktq8j 4 6 10.1086/497097 10.1086/497097 CD cord-015516-hx7ktq8j 5 1 sha sha NNP cord-015516-hx7ktq8j 5 2 : : : cord-015516-hx7ktq8j 6 1 36cf85bc4c8dcce8def36349bc775e13ed6dba66 36cf85bc4c8dcce8def36349bc775e13ed6dba66 : cord-015516-hx7ktq8j 6 2 doc_id doc_id CD cord-015516-hx7ktq8j 6 3 : : : cord-015516-hx7ktq8j 6 4 15516 15516 CD cord-015516-hx7ktq8j 6 5 cord_uid cord_uid NNS cord-015516-hx7ktq8j 6 6 : : : cord-015516-hx7ktq8j 6 7 hx7ktq8j hx7ktq8j UH cord-015516-hx7ktq8j 7 1 nan nan NNP cord-015516-hx7ktq8j 7 2 ACE ACE NNP cord-015516-hx7ktq8j 7 3 converts convert VBZ cord-015516-hx7ktq8j 7 4 angiotensin angiotensin NN cord-015516-hx7ktq8j 7 5 I -PRON- PRP cord-015516-hx7ktq8j 7 6 to to IN cord-015516-hx7ktq8j 7 7 angiotensin angiotensin NN cord-015516-hx7ktq8j 7 8 II II NNP cord-015516-hx7ktq8j 7 9 . . . cord-015516-hx7ktq8j 8 1 The the DT cord-015516-hx7ktq8j 8 2 carboxypeptidase carboxypeptidase NN cord-015516-hx7ktq8j 8 3 ACE2 ACE2 NNP cord-015516-hx7ktq8j 8 4 negatively negatively RB cord-015516-hx7ktq8j 8 5 regulates regulate VBZ cord-015516-hx7ktq8j 8 6 angiotensin angiotensin NN cord-015516-hx7ktq8j 8 7 II ii CD cord-015516-hx7ktq8j 8 8 production production NN cord-015516-hx7ktq8j 8 9 by by IN cord-015516-hx7ktq8j 8 10 cleaving cleave VBG cord-015516-hx7ktq8j 8 11 a a DT cord-015516-hx7ktq8j 8 12 single single JJ cord-015516-hx7ktq8j 8 13 residue residue NN cord-015516-hx7ktq8j 8 14 from from IN cord-015516-hx7ktq8j 8 15 both both DT cord-015516-hx7ktq8j 8 16 angiotensin angiotensin NN cord-015516-hx7ktq8j 8 17 I I NNP cord-015516-hx7ktq8j 8 18 and and CC cord-015516-hx7ktq8j 8 19 II II NNP cord-015516-hx7ktq8j 8 20 , , , cord-015516-hx7ktq8j 8 21 thus thus RB cord-015516-hx7ktq8j 8 22 interfering interfere VBG cord-015516-hx7ktq8j 8 23 with with IN cord-015516-hx7ktq8j 8 24 the the DT cord-015516-hx7ktq8j 8 25 renin renin NN cord-015516-hx7ktq8j 8 26 - - HYPH cord-015516-hx7ktq8j 8 27 angiotensin angiotensin NN cord-015516-hx7ktq8j 8 28 cascade cascade NN cord-015516-hx7ktq8j 8 29 . . . cord-015516-hx7ktq8j 9 1 This this DT cord-015516-hx7ktq8j 9 2 cascade cascade NN cord-015516-hx7ktq8j 9 3 has have VBZ cord-015516-hx7ktq8j 9 4 recently recently RB cord-015516-hx7ktq8j 9 5 been be VBN cord-015516-hx7ktq8j 9 6 demonstrated demonstrate VBN cord-015516-hx7ktq8j 9 7 to to TO cord-015516-hx7ktq8j 9 8 play play VB cord-015516-hx7ktq8j 9 9 a a DT cord-015516-hx7ktq8j 9 10 role role NN cord-015516-hx7ktq8j 9 11 in in IN cord-015516-hx7ktq8j 9 12 diffuse diffuse JJ cord-015516-hx7ktq8j 9 13 pulmonary pulmonary JJ cord-015516-hx7ktq8j 9 14 alveolar alveolar NN cord-015516-hx7ktq8j 9 15 injury injury NN cord-015516-hx7ktq8j 9 16 mediated mediate VBN cord-015516-hx7ktq8j 9 17 by by IN cord-015516-hx7ktq8j 9 18 the the DT cord-015516-hx7ktq8j 9 19 interaction interaction NN cord-015516-hx7ktq8j 9 20 of of IN cord-015516-hx7ktq8j 9 21 angiotensin angiotensin NN cord-015516-hx7ktq8j 9 22 II II NNP cord-015516-hx7ktq8j 9 23 with with IN cord-015516-hx7ktq8j 9 24 angiotensin angiotensin NN cord-015516-hx7ktq8j 9 25 II II NNP cord-015516-hx7ktq8j 9 26 receptor receptor NN cord-015516-hx7ktq8j 9 27 type type NN cord-015516-hx7ktq8j 9 28 1 1 CD cord-015516-hx7ktq8j 9 29 . . . cord-015516-hx7ktq8j 10 1 ACE2 ACE2 NNP cord-015516-hx7ktq8j 10 2 has have VBZ cord-015516-hx7ktq8j 10 3 been be VBN cord-015516-hx7ktq8j 10 4 demonstrated demonstrate VBN cord-015516-hx7ktq8j 10 5 in in IN cord-015516-hx7ktq8j 10 6 vitro vitro FW cord-015516-hx7ktq8j 10 7 to to TO cord-015516-hx7ktq8j 10 8 be be VB cord-015516-hx7ktq8j 10 9 a a DT cord-015516-hx7ktq8j 10 10 cell cell NN cord-015516-hx7ktq8j 10 11 - - HYPH cord-015516-hx7ktq8j 10 12 surface surface NN cord-015516-hx7ktq8j 10 13 receptor receptor NN cord-015516-hx7ktq8j 10 14 for for IN cord-015516-hx7ktq8j 10 15 the the DT cord-015516-hx7ktq8j 10 16 surface surface NN cord-015516-hx7ktq8j 10 17 spike spike NN cord-015516-hx7ktq8j 10 18 protein protein NN cord-015516-hx7ktq8j 10 19 of of IN cord-015516-hx7ktq8j 10 20 the the DT cord-015516-hx7ktq8j 10 21 SARS SARS NNP cord-015516-hx7ktq8j 10 22 coronavirus coronavirus NN cord-015516-hx7ktq8j 10 23 . . . cord-015516-hx7ktq8j 11 1 This this DT cord-015516-hx7ktq8j 11 2 suggests suggest VBZ cord-015516-hx7ktq8j 11 3 the the DT cord-015516-hx7ktq8j 11 4 possibility possibility NN cord-015516-hx7ktq8j 11 5 that that IN cord-015516-hx7ktq8j 11 6 the the DT cord-015516-hx7ktq8j 11 7 severe severe JJ cord-015516-hx7ktq8j 11 8 diffuse diffuse JJ cord-015516-hx7ktq8j 11 9 alveolar alveolar NN cord-015516-hx7ktq8j 11 10 damage damage NN cord-015516-hx7ktq8j 11 11 commonly commonly RB cord-015516-hx7ktq8j 11 12 seen see VBN cord-015516-hx7ktq8j 11 13 in in IN cord-015516-hx7ktq8j 11 14 patients patient NNS cord-015516-hx7ktq8j 11 15 with with IN cord-015516-hx7ktq8j 11 16 SARS SARS NNP cord-015516-hx7ktq8j 11 17 may may MD cord-015516-hx7ktq8j 11 18 be be VB cord-015516-hx7ktq8j 11 19 , , , cord-015516-hx7ktq8j 11 20 at at IN cord-015516-hx7ktq8j 11 21 least least JJS cord-015516-hx7ktq8j 11 22 in in IN cord-015516-hx7ktq8j 11 23 part part NN cord-015516-hx7ktq8j 11 24 , , , cord-015516-hx7ktq8j 11 25 the the DT cord-015516-hx7ktq8j 11 26 consequence consequence NN cord-015516-hx7ktq8j 11 27 of of IN cord-015516-hx7ktq8j 11 28 the the DT cord-015516-hx7ktq8j 11 29 effects effect NNS cord-015516-hx7ktq8j 11 30 of of IN cord-015516-hx7ktq8j 11 31 angiotensin angiotensin NN cord-015516-hx7ktq8j 11 32 II II NNP cord-015516-hx7ktq8j 11 33 . . . cord-015516-hx7ktq8j 12 1 If if IN cord-015516-hx7ktq8j 12 2 so so RB cord-015516-hx7ktq8j 12 3 , , , cord-015516-hx7ktq8j 12 4 the the DT cord-015516-hx7ktq8j 12 5 down down JJ cord-015516-hx7ktq8j 12 6 - - HYPH cord-015516-hx7ktq8j 12 7 regulatory regulatory JJ cord-015516-hx7ktq8j 12 8 effects effect NNS cord-015516-hx7ktq8j 12 9 of of IN cord-015516-hx7ktq8j 12 10 ACE2 ACE2 NNP cord-015516-hx7ktq8j 12 11 could could MD cord-015516-hx7ktq8j 12 12 play play VB cord-015516-hx7ktq8j 12 13 a a DT cord-015516-hx7ktq8j 12 14 protective protective JJ cord-015516-hx7ktq8j 12 15 role role NN cord-015516-hx7ktq8j 12 16 . . . cord-015516-hx7ktq8j 13 1 Experimental experimental JJ cord-015516-hx7ktq8j 13 2 pulmonary pulmonary JJ cord-015516-hx7ktq8j 13 3 infection infection NN cord-015516-hx7ktq8j 13 4 with with IN cord-015516-hx7ktq8j 13 5 SARS SARS NNP cord-015516-hx7ktq8j 13 6 coronavirus coronavirus NN cord-015516-hx7ktq8j 13 7 infection infection NN cord-015516-hx7ktq8j 13 8 in in IN cord-015516-hx7ktq8j 13 9 mice mouse NNS cord-015516-hx7ktq8j 13 10 reduced reduce VBD cord-015516-hx7ktq8j 13 11 the the DT cord-015516-hx7ktq8j 13 12 expression expression NN cord-015516-hx7ktq8j 13 13 of of IN cord-015516-hx7ktq8j 13 14 ACE2 ACE2 NNP cord-015516-hx7ktq8j 13 15 in in IN cord-015516-hx7ktq8j 13 16 the the DT cord-015516-hx7ktq8j 13 17 lungs lung NNS cord-015516-hx7ktq8j 13 18 and and CC cord-015516-hx7ktq8j 13 19 , , , cord-015516-hx7ktq8j 13 20 as as IN cord-015516-hx7ktq8j 13 21 also also RB cord-015516-hx7ktq8j 13 22 occurs occur VBZ cord-015516-hx7ktq8j 13 23 in in IN cord-015516-hx7ktq8j 13 24 humans human NNS cord-015516-hx7ktq8j 13 25 , , , cord-015516-hx7ktq8j 13 26 caused cause VBD cord-015516-hx7ktq8j 13 27 diffuse diffuse JJ cord-015516-hx7ktq8j 13 28 lung lung NN cord-015516-hx7ktq8j 13 29 injury injury NN cord-015516-hx7ktq8j 13 30 . . . cord-015516-hx7ktq8j 14 1 These these DT cord-015516-hx7ktq8j 14 2 findings finding NNS cord-015516-hx7ktq8j 14 3 were be VBD cord-015516-hx7ktq8j 14 4 reproduced reproduce VBN cord-015516-hx7ktq8j 14 5 by by IN cord-015516-hx7ktq8j 14 6 exposure exposure NN cord-015516-hx7ktq8j 14 7 to to IN cord-015516-hx7ktq8j 14 8 SARS SARS NNP cord-015516-hx7ktq8j 14 9 coronavirus coronavirus NN cord-015516-hx7ktq8j 14 10 spike spike NN cord-015516-hx7ktq8j 14 11 protein protein NN cord-015516-hx7ktq8j 14 12 in in IN cord-015516-hx7ktq8j 14 13 the the DT cord-015516-hx7ktq8j 14 14 absence absence NN cord-015516-hx7ktq8j 14 15 of of IN cord-015516-hx7ktq8j 14 16 replicative replicative JJ cord-015516-hx7ktq8j 14 17 virus virus NN cord-015516-hx7ktq8j 14 18 . . . cord-015516-hx7ktq8j 15 1 In in IN cord-015516-hx7ktq8j 15 2 a a DT cord-015516-hx7ktq8j 15 3 murine murine JJ cord-015516-hx7ktq8j 15 4 model model NN cord-015516-hx7ktq8j 15 5 of of IN cord-015516-hx7ktq8j 15 6 acute acute JJ cord-015516-hx7ktq8j 15 7 lung lung NN cord-015516-hx7ktq8j 15 8 injury injury NN cord-015516-hx7ktq8j 15 9 due due IN cord-015516-hx7ktq8j 15 10 to to IN cord-015516-hx7ktq8j 15 11 acid acid JJ cord-015516-hx7ktq8j 15 12 aspiration aspiration NN cord-015516-hx7ktq8j 15 13 , , , cord-015516-hx7ktq8j 15 14 SARS SARS NNP cord-015516-hx7ktq8j 15 15 coronavirus coronavirus NN cord-015516-hx7ktq8j 15 16 spike spike NN cord-015516-hx7ktq8j 15 17 protein protein NN cord-015516-hx7ktq8j 15 18 exacerbated exacerbate VBD cord-015516-hx7ktq8j 15 19 lung lung NN cord-015516-hx7ktq8j 15 20 failure failure NN cord-015516-hx7ktq8j 15 21 by by IN cord-015516-hx7ktq8j 15 22 down down NN cord-015516-hx7ktq8j 15 23 - - HYPH cord-015516-hx7ktq8j 15 24 regulation regulation NN cord-015516-hx7ktq8j 15 25 of of IN cord-015516-hx7ktq8j 15 26 the the DT cord-015516-hx7ktq8j 15 27 renin renin NN cord-015516-hx7ktq8j 15 28 - - HYPH cord-015516-hx7ktq8j 15 29 angiotensin angiotensin NN cord-015516-hx7ktq8j 15 30 system system NN cord-015516-hx7ktq8j 15 31 . . . cord-015516-hx7ktq8j 16 1 SARS SARS NNP cord-015516-hx7ktq8j 16 2 coronavirus coronavirus NN cord-015516-hx7ktq8j 16 3 Spike Spike NNP cord-015516-hx7ktq8j 16 4 protein protein NN cord-015516-hx7ktq8j 16 5 - - HYPH cord-015516-hx7ktq8j 16 6 induced induce VBN cord-015516-hx7ktq8j 16 7 lung lung NN cord-015516-hx7ktq8j 16 8 failure failure NN cord-015516-hx7ktq8j 16 9 could could MD cord-015516-hx7ktq8j 16 10 be be VB cord-015516-hx7ktq8j 16 11 mitigated mitigate VBN cord-015516-hx7ktq8j 16 12 by by IN cord-015516-hx7ktq8j 16 13 inhibition inhibition NN cord-015516-hx7ktq8j 16 14 with with IN cord-015516-hx7ktq8j 16 15 angiotensin angiotensin NN cord-015516-hx7ktq8j 16 16 II II NNP cord-015516-hx7ktq8j 16 17 receptor receptor NN cord-015516-hx7ktq8j 16 18 type type NN cord-015516-hx7ktq8j 16 19 1 1 CD cord-015516-hx7ktq8j 16 20 , , , cord-015516-hx7ktq8j 16 21 the the DT cord-015516-hx7ktq8j 16 22 receptor receptor NN cord-015516-hx7ktq8j 16 23 that that WDT cord-015516-hx7ktq8j 16 24 mediates mediate VBZ cord-015516-hx7ktq8j 16 25 angiotensin angiotensin NN cord-015516-hx7ktq8j 16 26 II II NNP cord-015516-hx7ktq8j 16 27 - - HYPH cord-015516-hx7ktq8j 16 28 induced induce VBN cord-015516-hx7ktq8j 16 29 vascular vascular JJ cord-015516-hx7ktq8j 16 30 permeability permeability NN cord-015516-hx7ktq8j 16 31 and and CC cord-015516-hx7ktq8j 16 32 lung lung NN cord-015516-hx7ktq8j 16 33 injury injury NN cord-015516-hx7ktq8j 16 34 . . . cord-015516-hx7ktq8j 17 1 In in IN cord-015516-hx7ktq8j 17 2 a a DT cord-015516-hx7ktq8j 17 3 separate separate JJ cord-015516-hx7ktq8j 17 4 publication publication NN cord-015516-hx7ktq8j 17 5 , , , cord-015516-hx7ktq8j 17 6 the the DT cord-015516-hx7ktq8j 17 7 same same JJ cord-015516-hx7ktq8j 17 8 investigators investigator NNS cord-015516-hx7ktq8j 17 9 demonstrated demonstrate VBD cord-015516-hx7ktq8j 17 10 that that IN cord-015516-hx7ktq8j 17 11 recombinant recombinant JJ cord-015516-hx7ktq8j 17 12 ACE2 ACE2 NNP cord-015516-hx7ktq8j 17 13 protects protect VBZ cord-015516-hx7ktq8j 17 14 mice mouse NNS cord-015516-hx7ktq8j 17 15 from from IN cord-015516-hx7ktq8j 17 16 acid acid JJ cord-015516-hx7ktq8j 17 17 aspiration aspiration NN cord-015516-hx7ktq8j 17 18 - - HYPH cord-015516-hx7ktq8j 17 19 induced induce VBN cord-015516-hx7ktq8j 17 20 lung lung NN cord-015516-hx7ktq8j 17 21 injury injury NN cord-015516-hx7ktq8j 17 22 [ [ -LRB- cord-015516-hx7ktq8j 17 23 1 1 CD cord-015516-hx7ktq8j 17 24 ] ] -RRB- cord-015516-hx7ktq8j 17 25 . . . cord-015516-hx7ktq8j 18 1 The the DT cord-015516-hx7ktq8j 18 2 investigators investigator NNS cord-015516-hx7ktq8j 18 3 also also RB cord-015516-hx7ktq8j 18 4 note note VBP cord-015516-hx7ktq8j 18 5 that that IN cord-015516-hx7ktq8j 18 6 ACE1 ace1 CD cord-015516-hx7ktq8j 18 7 polymorphisms polymorphism NNS cord-015516-hx7ktq8j 18 8 have have VBP cord-015516-hx7ktq8j 18 9 been be VBN cord-015516-hx7ktq8j 18 10 associated associate VBN cord-015516-hx7ktq8j 18 11 with with IN cord-015516-hx7ktq8j 18 12 progression progression NN cord-015516-hx7ktq8j 18 13 of of IN cord-015516-hx7ktq8j 18 14 SARS SARS NNP cord-015516-hx7ktq8j 18 15 [ [ -LRB- cord-015516-hx7ktq8j 18 16 2 2 CD cord-015516-hx7ktq8j 18 17 ] ] -RRB- cord-015516-hx7ktq8j 18 18 . . . cord-015516-hx7ktq8j 19 1 On on IN cord-015516-hx7ktq8j 19 2 the the DT cord-015516-hx7ktq8j 19 3 basis basis NN cord-015516-hx7ktq8j 19 4 of of IN cord-015516-hx7ktq8j 19 5 these these DT cord-015516-hx7ktq8j 19 6 findings finding NNS cord-015516-hx7ktq8j 19 7 , , , cord-015516-hx7ktq8j 19 8 the the DT cord-015516-hx7ktq8j 19 9 investigators investigator NNS cord-015516-hx7ktq8j 19 10 proposed propose VBD cord-015516-hx7ktq8j 19 11 that that IN cord-015516-hx7ktq8j 19 12 the the DT cord-015516-hx7ktq8j 19 13 severe severe JJ cord-015516-hx7ktq8j 19 14 pulmonary pulmonary JJ cord-015516-hx7ktq8j 19 15 alveolar alveolar NN cord-015516-hx7ktq8j 19 16 injury injury NN cord-015516-hx7ktq8j 19 17 seen see VBN cord-015516-hx7ktq8j 19 18 in in IN cord-015516-hx7ktq8j 19 19 patients patient NNS cord-015516-hx7ktq8j 19 20 with with IN cord-015516-hx7ktq8j 19 21 SARS SARS NNP cord-015516-hx7ktq8j 19 22 is be VBZ cord-015516-hx7ktq8j 19 23 the the DT cord-015516-hx7ktq8j 19 24 consequence consequence NN cord-015516-hx7ktq8j 19 25 of of IN cord-015516-hx7ktq8j 19 26 SARS SARS NNP cord-015516-hx7ktq8j 19 27 coronavirus coronavirus NN cord-015516-hx7ktq8j 19 28 spike spike NN cord-015516-hx7ktq8j 19 29 surface surface NN cord-015516-hx7ktq8j 19 30 protein protein NN cord-015516-hx7ktq8j 19 31 - - HYPH cord-015516-hx7ktq8j 19 32 associated associate VBN cord-015516-hx7ktq8j 19 33 down down IN cord-015516-hx7ktq8j 19 34 - - HYPH cord-015516-hx7ktq8j 19 35 regulation regulation NN cord-015516-hx7ktq8j 19 36 of of IN cord-015516-hx7ktq8j 19 37 ACE2 ACE2 NNP cord-015516-hx7ktq8j 19 38 . . . cord-015516-hx7ktq8j 20 1 The the DT cord-015516-hx7ktq8j 20 2 decreased decreased JJ cord-015516-hx7ktq8j 20 3 availability availability NN cord-015516-hx7ktq8j 20 4 of of IN cord-015516-hx7ktq8j 20 5 ACE2 ACE2 NNP cord-015516-hx7ktq8j 20 6 impairs impair VBZ cord-015516-hx7ktq8j 20 7 the the DT cord-015516-hx7ktq8j 20 8 ability ability NN cord-015516-hx7ktq8j 20 9 to to IN cord-015516-hx7ktq8j 20 10 down down RB cord-015516-hx7ktq8j 20 11 - - HYPH cord-015516-hx7ktq8j 20 12 regulate regulate VB cord-015516-hx7ktq8j 20 13 the the DT cord-015516-hx7ktq8j 20 14 renin renin NN cord-015516-hx7ktq8j 20 15 - - HYPH cord-015516-hx7ktq8j 20 16 angiotensin angiotensin NN cord-015516-hx7ktq8j 20 17 system system NN cord-015516-hx7ktq8j 20 18 , , , cord-015516-hx7ktq8j 20 19 exacerbating exacerbate VBG cord-015516-hx7ktq8j 20 20 lung lung NN cord-015516-hx7ktq8j 20 21 injury injury NN cord-015516-hx7ktq8j 20 22 . . . cord-015516-hx7ktq8j 21 1 The the DT cord-015516-hx7ktq8j 21 2 authors author NNS cord-015516-hx7ktq8j 21 3 suggest suggest VBP cord-015516-hx7ktq8j 21 4 that that IN cord-015516-hx7ktq8j 21 5 recombinant recombinant JJ cord-015516-hx7ktq8j 21 6 ACE2 ACE2 NNP cord-015516-hx7ktq8j 21 7 protein protein NN cord-015516-hx7ktq8j 21 8 could could MD cord-015516-hx7ktq8j 21 9 be be VB cord-015516-hx7ktq8j 21 10 a a DT cord-015516-hx7ktq8j 21 11 potential potential JJ cord-015516-hx7ktq8j 21 12 therapeutic therapeutic JJ cord-015516-hx7ktq8j 21 13 agent agent NN cord-015516-hx7ktq8j 21 14 in in IN cord-015516-hx7ktq8j 21 15 this this DT cord-015516-hx7ktq8j 21 16 and and CC cord-015516-hx7ktq8j 21 17 related related JJ cord-015516-hx7ktq8j 21 18 pulmonary pulmonary JJ cord-015516-hx7ktq8j 21 19 infections infection NNS cord-015516-hx7ktq8j 21 20 and and CC cord-015516-hx7ktq8j 21 21 diffuse diffuse VB cord-015516-hx7ktq8j 21 22 alveolar alveolar JJ cord-015516-hx7ktq8j 21 23 injuries injury NNS cord-015516-hx7ktq8j 21 24 . . . cord-015516-hx7ktq8j 22 1 Trim5 Trim5 NNP cord-015516-hx7ktq8j 22 2 is be VBZ cord-015516-hx7ktq8j 22 3 an an DT cord-015516-hx7ktq8j 22 4 intracellular intracellular JJ cord-015516-hx7ktq8j 22 5 retroviral retroviral NN cord-015516-hx7ktq8j 22 6 restriction restriction NN cord-015516-hx7ktq8j 22 7 factor factor NN cord-015516-hx7ktq8j 22 8 that that WDT cord-015516-hx7ktq8j 22 9 effectively effectively RB cord-015516-hx7ktq8j 22 10 binds bind VBZ cord-015516-hx7ktq8j 22 11 to to IN cord-015516-hx7ktq8j 22 12 incoming incoming JJ cord-015516-hx7ktq8j 22 13 retroviral retroviral JJ cord-015516-hx7ktq8j 22 14 capsids capsid NNS cord-015516-hx7ktq8j 22 15 and and CC cord-015516-hx7ktq8j 22 16 inhibits inhibit VBZ cord-015516-hx7ktq8j 22 17 their -PRON- PRP$ cord-015516-hx7ktq8j 22 18 replication replication NN cord-015516-hx7ktq8j 22 19 at at IN cord-015516-hx7ktq8j 22 20 a a DT cord-015516-hx7ktq8j 22 21 stage stage NN cord-015516-hx7ktq8j 22 22 prior prior RB cord-015516-hx7ktq8j 22 23 to to IN cord-015516-hx7ktq8j 22 24 or or CC cord-015516-hx7ktq8j 22 25 concurrent concurrent JJ cord-015516-hx7ktq8j 22 26 with with IN cord-015516-hx7ktq8j 22 27 reverse reverse JJ cord-015516-hx7ktq8j 22 28 transcription transcription NN cord-015516-hx7ktq8j 22 29 . . . cord-015516-hx7ktq8j 23 1 Trim5a trim5a DT cord-015516-hx7ktq8j 23 2 appears appear VBZ cord-015516-hx7ktq8j 23 3 to to TO cord-015516-hx7ktq8j 23 4 account account VB cord-015516-hx7ktq8j 23 5 for for IN cord-015516-hx7ktq8j 23 6 the the DT cord-015516-hx7ktq8j 23 7 resistance resistance NN cord-015516-hx7ktq8j 23 8 of of IN cord-015516-hx7ktq8j 23 9 Old Old NNP cord-015516-hx7ktq8j 23 10 World World NNP cord-015516-hx7ktq8j 23 11 monkeys monkey NNS cord-015516-hx7ktq8j 23 12 to to IN cord-015516-hx7ktq8j 23 13 HIV-1 HIV-1 NNP cord-015516-hx7ktq8j 23 14 infection infection NN cord-015516-hx7ktq8j 23 15 . . . cord-015516-hx7ktq8j 24 1 Human Human NNP cord-015516-hx7ktq8j 24 2 Trim5a Trim5a NNP cord-015516-hx7ktq8j 24 3 , , , cord-015516-hx7ktq8j 24 4 in in IN cord-015516-hx7ktq8j 24 5 contrast contrast NN cord-015516-hx7ktq8j 24 6 , , , cord-015516-hx7ktq8j 24 7 is be VBZ cord-015516-hx7ktq8j 24 8 unable unable JJ cord-015516-hx7ktq8j 24 9 to to TO cord-015516-hx7ktq8j 24 10 abort abort VB cord-015516-hx7ktq8j 24 11 intracellular intracellular JJ cord-015516-hx7ktq8j 24 12 HIV-1 HIV-1 NNP cord-015516-hx7ktq8j 24 13 infection infection NN cord-015516-hx7ktq8j 24 14 , , , cord-015516-hx7ktq8j 24 15 despite despite IN cord-015516-hx7ktq8j 24 16 having have VBG cord-015516-hx7ktq8j 24 17 87 87 CD cord-015516-hx7ktq8j 24 18 % % NN cord-015516-hx7ktq8j 24 19 homology homology NN cord-015516-hx7ktq8j 24 20 at at IN cord-015516-hx7ktq8j 24 21 the the DT cord-015516-hx7ktq8j 24 22 amino amino NN cord-015516-hx7ktq8j 24 23 acid acid NN cord-015516-hx7ktq8j 24 24 level level NN cord-015516-hx7ktq8j 24 25 with with IN cord-015516-hx7ktq8j 24 26 its -PRON- PRP$ cord-015516-hx7ktq8j 24 27 rhesus rhesus NNP cord-015516-hx7ktq8j 24 28 monkey monkey NN cord-015516-hx7ktq8j 24 29 counterpart counterpart NN cord-015516-hx7ktq8j 24 30 . . . cord-015516-hx7ktq8j 25 1 Stoye stoye JJ cord-015516-hx7ktq8j 25 2 and and CC cord-015516-hx7ktq8j 25 3 colleagues colleague NNS cord-015516-hx7ktq8j 25 4 explored explore VBD cord-015516-hx7ktq8j 25 5 the the DT cord-015516-hx7ktq8j 25 6 difference difference NN cord-015516-hx7ktq8j 25 7 between between IN cord-015516-hx7ktq8j 25 8 simian simian JJ cord-015516-hx7ktq8j 25 9 and and CC cord-015516-hx7ktq8j 25 10 human human JJ cord-015516-hx7ktq8j 25 11 Trim5a Trim5a -RRB- cord-015516-hx7ktq8j 25 12 by by IN cord-015516-hx7ktq8j 25 13 constructing construct VBG cord-015516-hx7ktq8j 25 14 chimeras chimera NNS cord-015516-hx7ktq8j 25 15 of of IN cord-015516-hx7ktq8j 25 16 human human NN cord-015516-hx7ktq8j 25 17 and and CC cord-015516-hx7ktq8j 25 18 rhesus rhesu NNS cord-015516-hx7ktq8j 25 19 monkey monkey NN cord-015516-hx7ktq8j 25 20 Trim5a trim5a DT cord-015516-hx7ktq8j 25 21 gene gene NN cord-015516-hx7ktq8j 25 22 se se FW cord-015516-hx7ktq8j 25 23 - - HYPH cord-015516-hx7ktq8j 25 24 quences quence NNS cord-015516-hx7ktq8j 25 25 and and CC cord-015516-hx7ktq8j 25 26 mapping map VBG cord-015516-hx7ktq8j 25 27 the the DT cord-015516-hx7ktq8j 25 28 regions region NNS cord-015516-hx7ktq8j 25 29 required require VBN cord-015516-hx7ktq8j 25 30 for for IN cord-015516-hx7ktq8j 25 31 HIV-1 HIV-1 NNP cord-015516-hx7ktq8j 25 32 restriction restriction NN cord-015516-hx7ktq8j 25 33 . . . cord-015516-hx7ktq8j 26 1 This this DT cord-015516-hx7ktq8j 26 2 approach approach NN cord-015516-hx7ktq8j 26 3 revealed reveal VBD cord-015516-hx7ktq8j 26 4 that that IN cord-015516-hx7ktq8j 26 5 the the DT cord-015516-hx7ktq8j 26 6 region region NN cord-015516-hx7ktq8j 26 7 involved involve VBN cord-015516-hx7ktq8j 26 8 in in IN cord-015516-hx7ktq8j 26 9 this this DT cord-015516-hx7ktq8j 26 10 restriction restriction NN cord-015516-hx7ktq8j 26 11 is be VBZ cord-015516-hx7ktq8j 26 12 the the DT cord-015516-hx7ktq8j 26 13 SPRY spry JJ cord-015516-hx7ktq8j 26 14 domain domain NN cord-015516-hx7ktq8j 26 15 of of IN cord-015516-hx7ktq8j 26 16 Trim5a trim5a CD cord-015516-hx7ktq8j 26 17 and and CC cord-015516-hx7ktq8j 26 18 that that IN cord-015516-hx7ktq8j 26 19 a a DT cord-015516-hx7ktq8j 26 20 single single JJ cord-015516-hx7ktq8j 26 21 amino amino NN cord-015516-hx7ktq8j 26 22 acid acid NN cord-015516-hx7ktq8j 26 23 substitution substitution NN cord-015516-hx7ktq8j 26 24 in in IN cord-015516-hx7ktq8j 26 25 the the DT cord-015516-hx7ktq8j 26 26 human human JJ cord-015516-hx7ktq8j 26 27 gene gene NN cord-015516-hx7ktq8j 26 28 product product NN cord-015516-hx7ktq8j 26 29 ( ( -LRB- cord-015516-hx7ktq8j 26 30 arginine arginine NN cord-015516-hx7ktq8j 26 31 for for IN cord-015516-hx7ktq8j 26 32 proline proline NN cord-015516-hx7ktq8j 26 33 at at IN cord-015516-hx7ktq8j 26 34 amino amino NN cord-015516-hx7ktq8j 26 35 acid acid NN cord-015516-hx7ktq8j 26 36 position position NN cord-015516-hx7ktq8j 26 37 332 332 CD cord-015516-hx7ktq8j 26 38 ) ) -RRB- cord-015516-hx7ktq8j 26 39 enables enable VBZ cord-015516-hx7ktq8j 26 40 human human JJ cord-015516-hx7ktq8j 26 41 cells cell NNS cord-015516-hx7ktq8j 26 42 to to TO cord-015516-hx7ktq8j 26 43 block block VB cord-015516-hx7ktq8j 26 44 HIV-1 HIV-1 NNP cord-015516-hx7ktq8j 26 45 replication replication NN cord-015516-hx7ktq8j 26 46 . . . cord-015516-hx7ktq8j 27 1 These these DT cord-015516-hx7ktq8j 27 2 findings finding NNS cord-015516-hx7ktq8j 27 3 suggest suggest VBP cord-015516-hx7ktq8j 27 4 that that IN cord-015516-hx7ktq8j 27 5 the the DT cord-015516-hx7ktq8j 27 6 vulnerability vulnerability NN cord-015516-hx7ktq8j 27 7 of of IN cord-015516-hx7ktq8j 27 8 the the DT cord-015516-hx7ktq8j 27 9 human human JJ cord-015516-hx7ktq8j 27 10 population population NN cord-015516-hx7ktq8j 27 11 to to IN cord-015516-hx7ktq8j 27 12 HIV-1 HIV-1 NNP cord-015516-hx7ktq8j 27 13 is be VBZ cord-015516-hx7ktq8j 27 14 the the DT cord-015516-hx7ktq8j 27 15 consequence consequence NN cord-015516-hx7ktq8j 27 16 of of IN cord-015516-hx7ktq8j 27 17 mutations mutation NNS cord-015516-hx7ktq8j 27 18 in in IN cord-015516-hx7ktq8j 27 19 Trim5a trim5a DT cord-015516-hx7ktq8j 27 20 during during IN cord-015516-hx7ktq8j 27 21 our -PRON- PRP$ cord-015516-hx7ktq8j 27 22 remote remote JJ cord-015516-hx7ktq8j 27 23 evolutionary evolutionary JJ cord-015516-hx7ktq8j 27 24 history history NN cord-015516-hx7ktq8j 27 25 . . . cord-015516-hx7ktq8j 28 1 Other other JJ cord-015516-hx7ktq8j 28 2 investigators investigator NNS cord-015516-hx7ktq8j 28 3 have have VBP cord-015516-hx7ktq8j 28 4 provided provide VBN cord-015516-hx7ktq8j 28 5 evidence evidence NN cord-015516-hx7ktq8j 28 6 for for IN cord-015516-hx7ktq8j 28 7 positive positive JJ cord-015516-hx7ktq8j 28 8 selection selection NN cord-015516-hx7ktq8j 28 9 within within IN cord-015516-hx7ktq8j 28 10 the the DT cord-015516-hx7ktq8j 28 11 relevant relevant JJ cord-015516-hx7ktq8j 28 12 SPRY spry JJ cord-015516-hx7ktq8j 28 13 domain domain NN cord-015516-hx7ktq8j 28 14 , , , cord-015516-hx7ktq8j 28 15 presumably presumably RB cord-015516-hx7ktq8j 28 16 as as IN cord-015516-hx7ktq8j 28 17 a a DT cord-015516-hx7ktq8j 28 18 consequence consequence NN cord-015516-hx7ktq8j 28 19 of of IN cord-015516-hx7ktq8j 28 20 ancient ancient JJ cord-015516-hx7ktq8j 28 21 exposures exposure NNS cord-015516-hx7ktq8j 28 22 to to IN cord-015516-hx7ktq8j 28 23 retrovirus retrovirus NN cord-015516-hx7ktq8j 28 24 [ [ -LRB- cord-015516-hx7ktq8j 28 25 1 1 CD cord-015516-hx7ktq8j 28 26 ] ] -RRB- cord-015516-hx7ktq8j 28 27 . . . cord-015516-hx7ktq8j 29 1 Finally finally RB cord-015516-hx7ktq8j 29 2 , , , cord-015516-hx7ktq8j 29 3 these these DT cord-015516-hx7ktq8j 29 4 results result NNS cord-015516-hx7ktq8j 29 5 point point VBP cord-015516-hx7ktq8j 29 6 to to IN cord-015516-hx7ktq8j 29 7 the the DT cord-015516-hx7ktq8j 29 8 potential potential JJ cord-015516-hx7ktq8j 29 9 therapeutic therapeutic JJ cord-015516-hx7ktq8j 29 10 value value NN cord-015516-hx7ktq8j 29 11 of of IN cord-015516-hx7ktq8j 29 12 molecules molecule NNS cord-015516-hx7ktq8j 29 13 that that WDT cord-015516-hx7ktq8j 29 14 mimic mimic VBP cord-015516-hx7ktq8j 29 15 Trim5a trim5a DT cord-015516-hx7ktq8j 29 16 , , , cord-015516-hx7ktq8j 29 17 as as RB cord-015516-hx7ktq8j 29 18 well well RB cord-015516-hx7ktq8j 29 19 as as IN cord-015516-hx7ktq8j 29 20 to to IN cord-015516-hx7ktq8j 29 21 the the DT cord-015516-hx7ktq8j 29 22 possibility possibility NN cord-015516-hx7ktq8j 29 23 of of IN cord-015516-hx7ktq8j 29 24 future future JJ cord-015516-hx7ktq8j 29 25 targeted target VBN cord-015516-hx7ktq8j 29 26 gene gene NN cord-015516-hx7ktq8j 29 27 therapy therapy NN cord-015516-hx7ktq8j 29 28 . . . cord-015516-hx7ktq8j 30 1 The the DT cord-015516-hx7ktq8j 30 2 golden golden JJ cord-015516-hx7ktq8j 30 3 pigment pigment NN cord-015516-hx7ktq8j 30 4 produced produce VBN cord-015516-hx7ktq8j 30 5 by by IN cord-015516-hx7ktq8j 30 6 S. S. NNP cord-015516-hx7ktq8j 30 7 aureus aureus NN cord-015516-hx7ktq8j 30 8 is be VBZ cord-015516-hx7ktq8j 30 9 compromised compromise VBN cord-015516-hx7ktq8j 30 10 of of IN cord-015516-hx7ktq8j 30 11 a a DT cord-015516-hx7ktq8j 30 12 group group NN cord-015516-hx7ktq8j 30 13 of of IN cord-015516-hx7ktq8j 30 14 carotenoids carotenoid NNS cord-015516-hx7ktq8j 30 15 . . . cord-015516-hx7ktq8j 31 1 Carotenoids carotenoid NNS cord-015516-hx7ktq8j 31 2 produced produce VBN cord-015516-hx7ktq8j 31 3 by by IN cord-015516-hx7ktq8j 31 4 fruits fruit NNS cord-015516-hx7ktq8j 31 5 and and CC cord-015516-hx7ktq8j 31 6 vegetables vegetable NNS cord-015516-hx7ktq8j 31 7 are be VBP cord-015516-hx7ktq8j 31 8 capable capable JJ cord-015516-hx7ktq8j 31 9 of of IN cord-015516-hx7ktq8j 31 10 scavenging scavenge VBG cord-015516-hx7ktq8j 31 11 free free JJ cord-015516-hx7ktq8j 31 12 radicals radical NNS cord-015516-hx7ktq8j 31 13 and and CC cord-015516-hx7ktq8j 31 14 quenching quench VBG cord-015516-hx7ktq8j 31 15 singlet singlet NN cord-015516-hx7ktq8j 31 16 oxygen oxygen NN cord-015516-hx7ktq8j 31 17 . . . cord-015516-hx7ktq8j 32 1 Liu Liu NNP cord-015516-hx7ktq8j 32 2 and and CC cord-015516-hx7ktq8j 32 3 colleagues colleague NNS cord-015516-hx7ktq8j 32 4 devised devise VBD cord-015516-hx7ktq8j 32 5 a a DT cord-015516-hx7ktq8j 32 6 set set NN cord-015516-hx7ktq8j 32 7 of of IN cord-015516-hx7ktq8j 32 8 experiments experiment NNS cord-015516-hx7ktq8j 32 9 designed design VBN cord-015516-hx7ktq8j 32 10 to to TO cord-015516-hx7ktq8j 32 11 examine examine VB cord-015516-hx7ktq8j 32 12 the the DT cord-015516-hx7ktq8j 32 13 hypothesis hypothesis NN cord-015516-hx7ktq8j 32 14 that that IN cord-015516-hx7ktq8j 32 15 carotenoids carotenoid NNS cord-015516-hx7ktq8j 32 16 produced produce VBN cord-015516-hx7ktq8j 32 17 by by IN cord-015516-hx7ktq8j 32 18 S. S. NNP cord-015516-hx7ktq8j 32 19 aureus aureu NNS cord-015516-hx7ktq8j 32 20 provide provide VBP cord-015516-hx7ktq8j 32 21 a a DT cord-015516-hx7ktq8j 32 22 survival survival NN cord-015516-hx7ktq8j 32 23 advantage advantage NN cord-015516-hx7ktq8j 32 24 to to IN cord-015516-hx7ktq8j 32 25 the the DT cord-015516-hx7ktq8j 32 26 organisms organism NNS cord-015516-hx7ktq8j 32 27 by by IN cord-015516-hx7ktq8j 32 28 allowing allow VBG cord-015516-hx7ktq8j 32 29 them -PRON- PRP cord-015516-hx7ktq8j 32 30 to to TO cord-015516-hx7ktq8j 32 31 resist resist VB cord-015516-hx7ktq8j 32 32 the the DT cord-015516-hx7ktq8j 32 33 oxygen oxygen NN cord-015516-hx7ktq8j 32 34 - - HYPH cord-015516-hx7ktq8j 32 35 dependent dependent JJ cord-015516-hx7ktq8j 32 36 bactericidal bactericidal JJ cord-015516-hx7ktq8j 32 37 activity activity NN cord-015516-hx7ktq8j 32 38 of of IN cord-015516-hx7ktq8j 32 39 phagocytic phagocytic JJ cord-015516-hx7ktq8j 32 40 cells cell NNS cord-015516-hx7ktq8j 32 41 . . . cord-015516-hx7ktq8j 33 1 With with IN cord-015516-hx7ktq8j 33 2 use use NN cord-015516-hx7ktq8j 33 3 of of IN cord-015516-hx7ktq8j 33 4 targeted target VBN cord-015516-hx7ktq8j 33 5 mutagenesis mutagenesis NN cord-015516-hx7ktq8j 33 6 and and CC cord-015516-hx7ktq8j 33 7 heterologous heterologous JJ cord-015516-hx7ktq8j 33 8 expression expression NN cord-015516-hx7ktq8j 33 9 , , , cord-015516-hx7ktq8j 33 10 they -PRON- PRP cord-015516-hx7ktq8j 33 11 demon demon NN cord-015516-hx7ktq8j 33 12 - - , cord-015516-hx7ktq8j 33 13 strated strate VBD cord-015516-hx7ktq8j 33 14 that that IN cord-015516-hx7ktq8j 33 15 mutant mutant JJ cord-015516-hx7ktq8j 33 16 ( ( -LRB- cord-015516-hx7ktq8j 33 17 knockout knockout NN cord-015516-hx7ktq8j 33 18 ) ) -RRB- cord-015516-hx7ktq8j 33 19 S. S. NNP cord-015516-hx7ktq8j 33 20 aureus aureus NN cord-015516-hx7ktq8j 33 21 with with IN cord-015516-hx7ktq8j 33 22 impaired impaired JJ cord-015516-hx7ktq8j 33 23 synthesis synthesis NN cord-015516-hx7ktq8j 33 24 of of IN cord-015516-hx7ktq8j 33 25 carotenoids carotenoid NNS cord-015516-hx7ktq8j 33 26 was be VBD cord-015516-hx7ktq8j 33 27 more more RBR cord-015516-hx7ktq8j 33 28 susceptible susceptible JJ cord-015516-hx7ktq8j 33 29 to to IN cord-015516-hx7ktq8j 33 30 killing kill VBG cord-015516-hx7ktq8j 33 31 by by IN cord-015516-hx7ktq8j 33 32 oxidants oxidant NNS cord-015516-hx7ktq8j 33 33 than than IN cord-015516-hx7ktq8j 33 34 was be VBD cord-015516-hx7ktq8j 33 35 the the DT cord-015516-hx7ktq8j 33 36 wild wild JJ cord-015516-hx7ktq8j 33 37 - - HYPH cord-015516-hx7ktq8j 33 38 type type NN cord-015516-hx7ktq8j 33 39 strain strain NN cord-015516-hx7ktq8j 33 40 . . . cord-015516-hx7ktq8j 34 1 Inhibition inhibition NN cord-015516-hx7ktq8j 34 2 of of IN cord-015516-hx7ktq8j 34 3 the the DT cord-015516-hx7ktq8j 34 4 neutrophil neutrophil NN cord-015516-hx7ktq8j 34 5 oxidative oxidative JJ cord-015516-hx7ktq8j 34 6 burst burst NN cord-015516-hx7ktq8j 34 7 eliminated eliminate VBD cord-015516-hx7ktq8j 34 8 the the DT cord-015516-hx7ktq8j 34 9 relative relative JJ cord-015516-hx7ktq8j 34 10 survival survival NN cord-015516-hx7ktq8j 34 11 advantage advantage NN cord-015516-hx7ktq8j 34 12 of of IN cord-015516-hx7ktq8j 34 13 wild wild JJ cord-015516-hx7ktq8j 34 14 - - HYPH cord-015516-hx7ktq8j 34 15 type type NN cord-015516-hx7ktq8j 34 16 S. S. NNP cord-015516-hx7ktq8j 34 17 aureus aureus NN cord-015516-hx7ktq8j 34 18 strains strain NNS cord-015516-hx7ktq8j 34 19 that that WDT cord-015516-hx7ktq8j 34 20 were be VBD cord-015516-hx7ktq8j 34 21 capable capable JJ cord-015516-hx7ktq8j 34 22 of of IN cord-015516-hx7ktq8j 34 23 normal normal JJ cord-015516-hx7ktq8j 34 24 carotenoid carotenoid NN cord-015516-hx7ktq8j 34 25 biosynthesis biosynthesis NN cord-015516-hx7ktq8j 34 26 . . . cord-015516-hx7ktq8j 35 1 Mutant mutant JJ cord-015516-hx7ktq8j 35 2 S. S. NNP cord-015516-hx7ktq8j 35 3 aureus aureus NN cord-015516-hx7ktq8j 35 4 strains strain NNS cord-015516-hx7ktq8j 35 5 were be VBD cord-015516-hx7ktq8j 35 6 incapable incapable JJ cord-015516-hx7ktq8j 35 7 of of IN cord-015516-hx7ktq8j 35 8 abscess abscess NN cord-015516-hx7ktq8j 35 9 formation formation NN cord-015516-hx7ktq8j 35 10 after after IN cord-015516-hx7ktq8j 35 11 subcutaneous subcutaneous JJ cord-015516-hx7ktq8j 35 12 injection injection NN cord-015516-hx7ktq8j 35 13 in in IN cord-015516-hx7ktq8j 35 14 mice mouse NNS cord-015516-hx7ktq8j 35 15 . . . cord-015516-hx7ktq8j 36 1 Heterologous heterologous JJ cord-015516-hx7ktq8j 36 2 expression expression NN cord-015516-hx7ktq8j 36 3 of of IN cord-015516-hx7ktq8j 36 4 S. S. NNP cord-015516-hx7ktq8j 36 5 aureus aureus NN cord-015516-hx7ktq8j 36 6 carotenoids carotenoid NNS cord-015516-hx7ktq8j 36 7 in in IN cord-015516-hx7ktq8j 36 8 Streptococcus streptococcus NN cord-015516-hx7ktq8j 36 9 pyogenes pyogene NNS cord-015516-hx7ktq8j 36 10 conferred confer VBD cord-015516-hx7ktq8j 36 11 relative relative JJ cord-015516-hx7ktq8j 36 12 resistance resistance NN cord-015516-hx7ktq8j 36 13 to to IN cord-015516-hx7ktq8j 36 14 oxidants oxidant NNS cord-015516-hx7ktq8j 36 15 and and CC cord-015516-hx7ktq8j 36 16 killing kill VBG cord-015516-hx7ktq8j 36 17 by by IN cord-015516-hx7ktq8j 36 18 neutrophils neutrophil NNS cord-015516-hx7ktq8j 36 19 , , , cord-015516-hx7ktq8j 36 20 as as RB cord-015516-hx7ktq8j 36 21 well well RB cord-015516-hx7ktq8j 36 22 as as IN cord-015516-hx7ktq8j 36 23 increased increase VBN cord-015516-hx7ktq8j 36 24 virulence virulence NN cord-015516-hx7ktq8j 36 25 in in IN cord-015516-hx7ktq8j 36 26 an an DT cord-015516-hx7ktq8j 36 27 animal animal NN cord-015516-hx7ktq8j 36 28 model model NN cord-015516-hx7ktq8j 36 29 of of IN cord-015516-hx7ktq8j 36 30 infection infection NN cord-015516-hx7ktq8j 36 31 . . . cord-015516-hx7ktq8j 37 1 A a DT cord-015516-hx7ktq8j 37 2 mixed mixed JJ cord-015516-hx7ktq8j 37 3 - - HYPH cord-015516-hx7ktq8j 37 4 function function NN cord-015516-hx7ktq8j 37 5 oxidase oxidase NN cord-015516-hx7ktq8j 37 6 inhibitor inhibitor NN cord-015516-hx7ktq8j 37 7 known know VBN cord-015516-hx7ktq8j 37 8 to to TO cord-015516-hx7ktq8j 37 9 inhibit inhibit VB cord-015516-hx7ktq8j 37 10 pigment pigment NN cord-015516-hx7ktq8j 37 11 formation formation NN cord-015516-hx7ktq8j 37 12 in in IN cord-015516-hx7ktq8j 37 13 S. S. NNP cord-015516-hx7ktq8j 37 14 aureus aureus NN cord-015516-hx7ktq8j 37 15 did do VBD cord-015516-hx7ktq8j 37 16 so so RB cord-015516-hx7ktq8j 37 17 in in IN cord-015516-hx7ktq8j 37 18 a a DT cord-015516-hx7ktq8j 37 19 dose dose NN cord-015516-hx7ktq8j 37 20 - - HYPH cord-015516-hx7ktq8j 37 21 dependent dependent JJ cord-015516-hx7ktq8j 37 22 fashion fashion NN cord-015516-hx7ktq8j 37 23 that that WDT cord-015516-hx7ktq8j 37 24 paralleled parallel VBD cord-015516-hx7ktq8j 37 25 an an DT cord-015516-hx7ktq8j 37 26 increase increase NN cord-015516-hx7ktq8j 37 27 in in IN cord-015516-hx7ktq8j 37 28 the the DT cord-015516-hx7ktq8j 37 29 susceptibility susceptibility NN cord-015516-hx7ktq8j 37 30 of of IN cord-015516-hx7ktq8j 37 31 the the DT cord-015516-hx7ktq8j 37 32 organism organism NN cord-015516-hx7ktq8j 37 33 to to IN cord-015516-hx7ktq8j 37 34 killing kill VBG cord-015516-hx7ktq8j 37 35 by by IN cord-015516-hx7ktq8j 37 36 singlet singlet NN cord-015516-hx7ktq8j 37 37 oxygen oxygen NN cord-015516-hx7ktq8j 37 38 , , , cord-015516-hx7ktq8j 37 39 as as RB cord-015516-hx7ktq8j 37 40 well well RB cord-015516-hx7ktq8j 37 41 as as IN cord-015516-hx7ktq8j 37 42 a a DT cord-015516-hx7ktq8j 37 43 decreased decrease VBN cord-015516-hx7ktq8j 37 44 survival survival NN cord-015516-hx7ktq8j 37 45 rate rate NN cord-015516-hx7ktq8j 37 46 in in IN cord-015516-hx7ktq8j 37 47 murine murine JJ cord-015516-hx7ktq8j 37 48 whole whole JJ cord-015516-hx7ktq8j 37 49 blood blood NN cord-015516-hx7ktq8j 37 50 . . . cord-015516-hx7ktq8j 38 1 This this DT cord-015516-hx7ktq8j 38 2 observation observation NN cord-015516-hx7ktq8j 38 3 indicates indicate VBZ cord-015516-hx7ktq8j 38 4 that that IN cord-015516-hx7ktq8j 38 5 targeting target VBG cord-015516-hx7ktq8j 38 6 the the DT cord-015516-hx7ktq8j 38 7 carotenoids carotenoid NNS cord-015516-hx7ktq8j 38 8 of of IN cord-015516-hx7ktq8j 38 9 S. S. NNP cord-015516-hx7ktq8j 38 10 aureus aureus NN cord-015516-hx7ktq8j 38 11 may may MD cord-015516-hx7ktq8j 38 12 provide provide VB cord-015516-hx7ktq8j 38 13 a a DT cord-015516-hx7ktq8j 38 14 fruitful fruitful JJ cord-015516-hx7ktq8j 38 15 approach approach NN cord-015516-hx7ktq8j 38 16 to to IN cord-015516-hx7ktq8j 38 17 the the DT cord-015516-hx7ktq8j 38 18 development development NN cord-015516-hx7ktq8j 38 19 of of IN cord-015516-hx7ktq8j 38 20 novel novel JJ cord-015516-hx7ktq8j 38 21 therapeutic therapeutic JJ cord-015516-hx7ktq8j 38 22 agents agent NNS cord-015516-hx7ktq8j 38 23 directed direct VBN cord-015516-hx7ktq8j 38 24 at at IN cord-015516-hx7ktq8j 38 25 this this DT cord-015516-hx7ktq8j 38 26 organism organism NN cord-015516-hx7ktq8j 38 27 . . . cord-015516-hx7ktq8j 39 1 Schwartz Schwartz NNP cord-015516-hx7ktq8j 39 2 and and CC cord-015516-hx7ktq8j 39 3 colleagues colleague NNS cord-015516-hx7ktq8j 39 4 identified identify VBD cord-015516-hx7ktq8j 39 5 81 81 CD cord-015516-hx7ktq8j 39 6 patients patient NNS cord-015516-hx7ktq8j 39 7 with with IN cord-015516-hx7ktq8j 39 8 definite definite JJ cord-015516-hx7ktq8j 39 9 ( ( -LRB- cord-015516-hx7ktq8j 39 10 ) ) -RRB- cord-015516-hx7ktq8j 39 11 or or CC cord-015516-hx7ktq8j 39 12 prob prob JJ cord-015516-hx7ktq8j 39 13 - - HYPH cord-015516-hx7ktq8j 39 14 n n NN cord-015516-hx7ktq8j 39 15 p p NN cord-015516-hx7ktq8j 39 16 48 48 CD cord-015516-hx7ktq8j 39 17 able able JJ cord-015516-hx7ktq8j 39 18 ( ( -LRB- cord-015516-hx7ktq8j 39 19 ) ) -RRB- cord-015516-hx7ktq8j 39 20 CNS CNS NNP cord-015516-hx7ktq8j 39 21 aspergillosis aspergillosis NNP cord-015516-hx7ktq8j 39 22 who who WP cord-015516-hx7ktq8j 39 23 had have VBD cord-015516-hx7ktq8j 39 24 n n NN cord-015516-hx7ktq8j 39 25 p p NN cord-015516-hx7ktq8j 39 26 33 33 CD cord-015516-hx7ktq8j 39 27 received receive VBD cord-015516-hx7ktq8j 39 28 treatment treatment NN cord-015516-hx7ktq8j 39 29 with with IN cord-015516-hx7ktq8j 39 30 voriconazole voriconazole NN cord-015516-hx7ktq8j 39 31 in in IN cord-015516-hx7ktq8j 39 32 either either CC cord-015516-hx7ktq8j 39 33 clinical clinical JJ cord-015516-hx7ktq8j 39 34 trials trial NNS cord-015516-hx7ktq8j 39 35 or or CC cord-015516-hx7ktq8j 39 36 compassionate compassionate JJ cord-015516-hx7ktq8j 39 37 - - HYPH cord-015516-hx7ktq8j 39 38 use use NN cord-015516-hx7ktq8j 39 39 programs program NNS cord-015516-hx7ktq8j 39 40 . . . cord-015516-hx7ktq8j 40 1 All all DT cord-015516-hx7ktq8j 40 2 patients patient NNS cord-015516-hx7ktq8j 40 3 but but CC cord-015516-hx7ktq8j 40 4 3 3 CD cord-015516-hx7ktq8j 40 5 had have VBD cord-015516-hx7ktq8j 40 6 received receive VBN cord-015516-hx7ktq8j 40 7 у1 у1 IN cord-015516-hx7ktq8j 40 8 systemic systemic JJ cord-015516-hx7ktq8j 40 9 antifungal antifungal JJ cord-015516-hx7ktq8j 40 10 agent agent NN cord-015516-hx7ktq8j 40 11 before before IN cord-015516-hx7ktq8j 40 12 receiving receive VBG cord-015516-hx7ktq8j 40 13 voriconazole voriconazole NNP cord-015516-hx7ktq8j 40 14 . . . cord-015516-hx7ktq8j 41 1 Thirty thirty CD cord-015516-hx7ktq8j 41 2 - - HYPH cord-015516-hx7ktq8j 41 3 one one CD cord-015516-hx7ktq8j 41 4 patients patient NNS cord-015516-hx7ktq8j 41 5 ( ( -LRB- cord-015516-hx7ktq8j 41 6 38 38 CD cord-015516-hx7ktq8j 41 7 % % NN cord-015516-hx7ktq8j 41 8 ) ) -RRB- cord-015516-hx7ktq8j 41 9 also also RB cord-015516-hx7ktq8j 41 10 underwent undergo VBD cord-015516-hx7ktq8j 41 11 neurosurgical neurosurgical JJ cord-015516-hx7ktq8j 41 12 procedures procedure NNS cord-015516-hx7ktq8j 41 13 ( ( -LRB- cord-015516-hx7ktq8j 41 14 14 14 CD cord-015516-hx7ktq8j 41 15 underwent undergo VBD cord-015516-hx7ktq8j 41 16 craniotomy craniotomy NN cord-015516-hx7ktq8j 41 17 and and CC cord-015516-hx7ktq8j 41 18 abscess abscess NN cord-015516-hx7ktq8j 41 19 resection resection NN cord-015516-hx7ktq8j 41 20 , , , cord-015516-hx7ktq8j 41 21 and and CC cord-015516-hx7ktq8j 41 22 12 12 CD cord-015516-hx7ktq8j 41 23 underwent undergo VBD cord-015516-hx7ktq8j 41 24 abscess abscess NN cord-015516-hx7ktq8j 41 25 drainage drainage NN cord-015516-hx7ktq8j 41 26 ) ) -RRB- cord-015516-hx7ktq8j 41 27 , , , cord-015516-hx7ktq8j 41 28 4 4 CD cord-015516-hx7ktq8j 41 29 patients patient NNS cord-015516-hx7ktq8j 41 30 underwent undergo VBD cord-015516-hx7ktq8j 41 31 shunting shunt VBG cord-015516-hx7ktq8j 41 32 , , , cord-015516-hx7ktq8j 41 33 and and CC cord-015516-hx7ktq8j 41 34 1 1 CD cord-015516-hx7ktq8j 41 35 patient patient NN cord-015516-hx7ktq8j 41 36 had have VBD cord-015516-hx7ktq8j 41 37 an an DT cord-015516-hx7ktq8j 41 38 Ommaya Ommaya NNP cord-015516-hx7ktq8j 41 39 reservoir reservoir NN cord-015516-hx7ktq8j 41 40 placed place VBN cord-015516-hx7ktq8j 41 41 . . . cord-015516-hx7ktq8j 42 1 Thirty thirty CD cord-015516-hx7ktq8j 42 2 - - HYPH cord-015516-hx7ktq8j 42 3 two two CD cord-015516-hx7ktq8j 42 4 patients patient NNS cord-015516-hx7ktq8j 42 5 were be VBD cord-015516-hx7ktq8j 42 6 recipients recipient NNS cord-015516-hx7ktq8j 42 7 of of IN cord-015516-hx7ktq8j 42 8 hematopoietic hematopoietic JJ cord-015516-hx7ktq8j 42 9 stem stem NN cord-015516-hx7ktq8j 42 10 cell cell NN cord-015516-hx7ktq8j 42 11 transplants transplant NNS cord-015516-hx7ktq8j 42 12 ( ( -LRB- cord-015516-hx7ktq8j 42 13 HSCTs hsct NNS cord-015516-hx7ktq8j 42 14 ) ) -RRB- cord-015516-hx7ktq8j 42 15 , , , cord-015516-hx7ktq8j 42 16 all all DT cord-015516-hx7ktq8j 42 17 but but IN cord-015516-hx7ktq8j 42 18 2 2 CD cord-015516-hx7ktq8j 42 19 of of IN cord-015516-hx7ktq8j 42 20 which which WDT cord-015516-hx7ktq8j 42 21 were be VBD cord-015516-hx7ktq8j 42 22 allogeneic allogeneic JJ cord-015516-hx7ktq8j 42 23 , , , cord-015516-hx7ktq8j 42 24 whereas whereas IN cord-015516-hx7ktq8j 42 25 11 11 CD cord-015516-hx7ktq8j 42 26 had have VBD cord-015516-hx7ktq8j 42 27 received receive VBN cord-015516-hx7ktq8j 42 28 solid solid JJ cord-015516-hx7ktq8j 42 29 organ organ NN cord-015516-hx7ktq8j 42 30 transplants transplant NNS cord-015516-hx7ktq8j 42 31 . . . cord-015516-hx7ktq8j 43 1 All all DT cord-015516-hx7ktq8j 43 2 but but IN cord-015516-hx7ktq8j 43 3 6 6 CD cord-015516-hx7ktq8j 43 4 of of IN cord-015516-hx7ktq8j 43 5 the the DT cord-015516-hx7ktq8j 43 6 50 50 CD cord-015516-hx7ktq8j 43 7 isolates isolate NNS cord-015516-hx7ktq8j 43 8 speciated speciate VBN cord-015516-hx7ktq8j 43 9 were be VBD cord-015516-hx7ktq8j 43 10 found find VBN cord-015516-hx7ktq8j 43 11 to to TO cord-015516-hx7ktq8j 43 12 be be VB cord-015516-hx7ktq8j 43 13 Aspergillus aspergillus NN cord-015516-hx7ktq8j 43 14 fumigatus fumigatus NN cord-015516-hx7ktq8j 43 15 . . . cord-015516-hx7ktq8j 44 1 A a DT cord-015516-hx7ktq8j 44 2 complete complete JJ cord-015516-hx7ktq8j 44 3 or or CC cord-015516-hx7ktq8j 44 4 partial partial JJ cord-015516-hx7ktq8j 44 5 response response NN cord-015516-hx7ktq8j 44 6 to to IN cord-015516-hx7ktq8j 44 7 voriconazole voriconazole NNP cord-015516-hx7ktq8j 44 8 was be VBD cord-015516-hx7ktq8j 44 9 achieved achieve VBN cord-015516-hx7ktq8j 44 10 in in IN cord-015516-hx7ktq8j 44 11 25 25 CD cord-015516-hx7ktq8j 44 12 patients patient NNS cord-015516-hx7ktq8j 44 13 ( ( -LRB- cord-015516-hx7ktq8j 44 14 35 35 CD cord-015516-hx7ktq8j 44 15 % % NN cord-015516-hx7ktq8j 44 16 ) ) -RRB- cord-015516-hx7ktq8j 44 17 overall overall RB cord-015516-hx7ktq8j 44 18 but but CC cord-015516-hx7ktq8j 44 19 in in IN cord-015516-hx7ktq8j 44 20 only only RB cord-015516-hx7ktq8j 44 21 16 16 CD cord-015516-hx7ktq8j 44 22 % % NN cord-015516-hx7ktq8j 44 23 of of IN cord-015516-hx7ktq8j 44 24 HSCT HSCT NNP cord-015516-hx7ktq8j 44 25 recipients recipient NNS cord-015516-hx7ktq8j 44 26 . . . cord-015516-hx7ktq8j 45 1 Thirty thirty CD cord-015516-hx7ktq8j 45 2 - - HYPH cord-015516-hx7ktq8j 45 3 one one CD cord-015516-hx7ktq8j 45 4 percent percent NN cord-015516-hx7ktq8j 45 5 of of IN cord-015516-hx7ktq8j 45 6 patients patient NNS cord-015516-hx7ktq8j 45 7 were be VBD cord-015516-hx7ktq8j 45 8 alive alive JJ cord-015516-hx7ktq8j 45 9 at at IN cord-015516-hx7ktq8j 45 10 the the DT cord-015516-hx7ktq8j 45 11 last last JJ cord-015516-hx7ktq8j 45 12 follow follow NN cord-015516-hx7ktq8j 45 13 - - HYPH cord-015516-hx7ktq8j 45 14 up up NN cord-015516-hx7ktq8j 45 15 visit visit NN cord-015516-hx7ktq8j 45 16 , , , cord-015516-hx7ktq8j 45 17 but but CC cord-015516-hx7ktq8j 45 18 only only RB cord-015516-hx7ktq8j 45 19 22 22 CD cord-015516-hx7ktq8j 45 20 % % NN cord-015516-hx7ktq8j 45 21 of of IN cord-015516-hx7ktq8j 45 22 HSCT HSCT NNP cord-015516-hx7ktq8j 45 23 recipients recipient NNS cord-015516-hx7ktq8j 45 24 and and CC cord-015516-hx7ktq8j 45 25 27 27 CD cord-015516-hx7ktq8j 45 26 % % NN cord-015516-hx7ktq8j 45 27 of of IN cord-015516-hx7ktq8j 45 28 solid solid JJ cord-015516-hx7ktq8j 45 29 organ organ NN cord-015516-hx7ktq8j 45 30 transplant transplant NN cord-015516-hx7ktq8j 45 31 recipients recipient NNS cord-015516-hx7ktq8j 45 32 had have VBD cord-015516-hx7ktq8j 45 33 survived survive VBN cord-015516-hx7ktq8j 45 34 . . . cord-015516-hx7ktq8j 46 1 Multivariate multivariate JJ cord-015516-hx7ktq8j 46 2 analysis analysis NN cord-015516-hx7ktq8j 46 3 found find VBD cord-015516-hx7ktq8j 46 4 that that IN cord-015516-hx7ktq8j 46 5 HSCT HSCT NNP cord-015516-hx7ktq8j 46 6 was be VBD cord-015516-hx7ktq8j 46 7 a a DT cord-015516-hx7ktq8j 46 8 significant significant JJ cord-015516-hx7ktq8j 46 9 predictor predictor NN cord-015516-hx7ktq8j 46 10 of of IN cord-015516-hx7ktq8j 46 11 a a DT cord-015516-hx7ktq8j 46 12 reduced reduce VBN cord-015516-hx7ktq8j 46 13 survival survival NN cord-015516-hx7ktq8j 46 14 rate rate NN cord-015516-hx7ktq8j 46 15 , , , cord-015516-hx7ktq8j 46 16 whereas whereas IN cord-015516-hx7ktq8j 46 17 neurosurgical neurosurgical JJ cord-015516-hx7ktq8j 46 18 procedures procedure NNS cord-015516-hx7ktq8j 46 19 were be VBD cord-015516-hx7ktq8j 46 20 associated associate VBN cord-015516-hx7ktq8j 46 21 with with IN cord-015516-hx7ktq8j 46 22 an an DT cord-015516-hx7ktq8j 46 23 improved improved JJ cord-015516-hx7ktq8j 46 24 survival survival NN cord-015516-hx7ktq8j 46 25 rate rate NN cord-015516-hx7ktq8j 46 26 . . . cord-015516-hx7ktq8j 47 1 However however RB cord-015516-hx7ktq8j 47 2 , , , cord-015516-hx7ktq8j 47 3 patients patient NNS cord-015516-hx7ktq8j 47 4 who who WP cord-015516-hx7ktq8j 47 5 underwent undergo VBD cord-015516-hx7ktq8j 47 6 such such JJ cord-015516-hx7ktq8j 47 7 procedures procedure NNS cord-015516-hx7ktq8j 47 8 were be VBD cord-015516-hx7ktq8j 47 9 less less RBR cord-015516-hx7ktq8j 47 10 likely likely JJ cord-015516-hx7ktq8j 47 11 to to TO cord-015516-hx7ktq8j 47 12 have have VB cord-015516-hx7ktq8j 47 13 multiple multiple JJ cord-015516-hx7ktq8j 47 14 brain brain NN cord-015516-hx7ktq8j 47 15 lesions lesion NNS cord-015516-hx7ktq8j 47 16 . . . cord-015516-hx7ktq8j 48 1 The the DT cord-015516-hx7ktq8j 48 2 potential potential JJ cord-015516-hx7ktq8j 48 3 role role NN cord-015516-hx7ktq8j 48 4 of of IN cord-015516-hx7ktq8j 48 5 surgical surgical JJ cord-015516-hx7ktq8j 48 6 intervention intervention NN cord-015516-hx7ktq8j 48 7 was be VBD cord-015516-hx7ktq8j 48 8 previously previously RB cord-015516-hx7ktq8j 48 9 suggested suggest VBN cord-015516-hx7ktq8j 48 10 in in IN cord-015516-hx7ktq8j 48 11 a a DT cord-015516-hx7ktq8j 48 12 review review NN cord-015516-hx7ktq8j 48 13 of of IN cord-015516-hx7ktq8j 48 14 26 26 CD cord-015516-hx7ktq8j 48 15 survivors survivor NNS cord-015516-hx7ktq8j 48 16 of of IN cord-015516-hx7ktq8j 48 17 cerebral cerebral JJ cord-015516-hx7ktq8j 48 18 aspergillosis aspergillosis NNP cord-015516-hx7ktq8j 48 19 , , , cord-015516-hx7ktq8j 48 20 21 21 CD cord-015516-hx7ktq8j 48 21 of of IN cord-015516-hx7ktq8j 48 22 whom whom WP cord-015516-hx7ktq8j 48 23 had have VBD cord-015516-hx7ktq8j 48 24 undergone undergo VBN cord-015516-hx7ktq8j 48 25 a a DT cord-015516-hx7ktq8j 48 26 neurosurgical neurosurgical JJ cord-015516-hx7ktq8j 48 27 procedure procedure NN cord-015516-hx7ktq8j 48 28 [ [ -LRB- cord-015516-hx7ktq8j 48 29 1 1 CD cord-015516-hx7ktq8j 48 30 ] ] -RRB- cord-015516-hx7ktq8j 48 31 . . . cord-015516-hx7ktq8j 49 1 As as RB cord-015516-hx7ktq8j 49 2 miserable miserable JJ cord-015516-hx7ktq8j 49 3 as as IN cord-015516-hx7ktq8j 49 4 these these DT cord-015516-hx7ktq8j 49 5 results result NNS cord-015516-hx7ktq8j 49 6 seem seem VBP cord-015516-hx7ktq8j 49 7 at at IN cord-015516-hx7ktq8j 49 8 first first JJ cord-015516-hx7ktq8j 49 9 glance glance NN cord-015516-hx7ktq8j 49 10 , , , cord-015516-hx7ktq8j 49 11 they -PRON- PRP cord-015516-hx7ktq8j 49 12 are be VBP cord-015516-hx7ktq8j 49 13 quite quite RB cord-015516-hx7ktq8j 49 14 superior superior JJ cord-015516-hx7ktq8j 49 15 to to IN cord-015516-hx7ktq8j 49 16 previously previously RB cord-015516-hx7ktq8j 49 17 published publish VBN cord-015516-hx7ktq8j 49 18 data datum NNS cord-015516-hx7ktq8j 49 19 , , , cord-015516-hx7ktq8j 49 20 which which WDT cord-015516-hx7ktq8j 49 21 have have VBP cord-015516-hx7ktq8j 49 22 indicated indicate VBN cord-015516-hx7ktq8j 49 23 that that IN cord-015516-hx7ktq8j 49 24 responses response NNS cord-015516-hx7ktq8j 49 25 to to IN cord-015516-hx7ktq8j 49 26 other other JJ cord-015516-hx7ktq8j 49 27 therapies therapy NNS cord-015516-hx7ktq8j 49 28 occur occur VBP cord-015516-hx7ktq8j 49 29 in in IN cord-015516-hx7ktq8j 49 30 as as RB cord-015516-hx7ktq8j 49 31 few few JJ cord-015516-hx7ktq8j 49 32 as as IN cord-015516-hx7ktq8j 49 33 10 10 CD cord-015516-hx7ktq8j 49 34 % % NN cord-015516-hx7ktq8j 49 35 of of IN cord-015516-hx7ktq8j 49 36 patients patient NNS cord-015516-hx7ktq8j 49 37 and and CC cord-015516-hx7ktq8j 49 38 that that IN cord-015516-hx7ktq8j 49 39 the the DT cord-015516-hx7ktq8j 49 40 fatality fatality NN cord-015516-hx7ktq8j 49 41 rate rate NN cord-015516-hx7ktq8j 49 42 for for IN cord-015516-hx7ktq8j 49 43 CNS CNS NNP cord-015516-hx7ktq8j 49 44 aspergillosis aspergillosis NN cord-015516-hx7ktq8j 49 45 in in IN cord-015516-hx7ktq8j 49 46 solid solid JJ cord-015516-hx7ktq8j 49 47 organ organ NN cord-015516-hx7ktq8j 49 48 transplant transplant NN cord-015516-hx7ktq8j 49 49 recipients recipient NNS cord-015516-hx7ktq8j 49 50 approaches approach VBZ cord-015516-hx7ktq8j 49 51 100 100 CD cord-015516-hx7ktq8j 49 52 % % NN cord-015516-hx7ktq8j 49 53 . . . cord-015516-hx7ktq8j 50 1 Although although IN cord-015516-hx7ktq8j 50 2 affected affect VBN cord-015516-hx7ktq8j 50 3 by by IN cord-015516-hx7ktq8j 50 4 the the DT cord-015516-hx7ktq8j 50 5 study study NN cord-015516-hx7ktq8j 50 6 's 's POS cord-015516-hx7ktq8j 50 7 observational observational JJ cord-015516-hx7ktq8j 50 8 nature nature NN cord-015516-hx7ktq8j 50 9 and and CC cord-015516-hx7ktq8j 50 10 likely likely JJ cord-015516-hx7ktq8j 50 11 selection selection NN cord-015516-hx7ktq8j 50 12 bias bias NN cord-015516-hx7ktq8j 50 13 , , , cord-015516-hx7ktq8j 50 14 these these DT cord-015516-hx7ktq8j 50 15 data datum NNS cord-015516-hx7ktq8j 50 16 strongly strongly RB cord-015516-hx7ktq8j 50 17 suggest suggest VBP cord-015516-hx7ktq8j 50 18 that that IN cord-015516-hx7ktq8j 50 19 voriconazole voriconazole NN cord-015516-hx7ktq8j 50 20 therapy therapy NN cord-015516-hx7ktq8j 50 21 is be VBZ cord-015516-hx7ktq8j 50 22 effective effective JJ cord-015516-hx7ktq8j 50 23 for for IN cord-015516-hx7ktq8j 50 24 some some DT cord-015516-hx7ktq8j 50 25 patients patient NNS cord-015516-hx7ktq8j 50 26 with with IN cord-015516-hx7ktq8j 50 27 CNS CNS NNP cord-015516-hx7ktq8j 50 28 aspergillosis aspergillosis NN cord-015516-hx7ktq8j 50 29 . . . cord-015516-hx7ktq8j 51 1 Furthermore furthermore RB cord-015516-hx7ktq8j 51 2 , , , cord-015516-hx7ktq8j 51 3 although although IN cord-015516-hx7ktq8j 51 4 objections objection NNS cord-015516-hx7ktq8j 51 5 can can MD cord-015516-hx7ktq8j 51 6 be be VB cord-015516-hx7ktq8j 51 7 made make VBN cord-015516-hx7ktq8j 51 8 with with IN cord-015516-hx7ktq8j 51 9 regard regard NN cord-015516-hx7ktq8j 51 10 to to IN cord-015516-hx7ktq8j 51 11 the the DT cord-015516-hx7ktq8j 51 12 findings finding NNS cord-015516-hx7ktq8j 51 13 for for IN cord-015516-hx7ktq8j 51 14 neurosurgical neurosurgical JJ cord-015516-hx7ktq8j 51 15 interventions intervention NNS cord-015516-hx7ktq8j 51 16 ( ( -LRB- cord-015516-hx7ktq8j 51 17 i.e. i.e. FW cord-015516-hx7ktq8j 51 18 , , , cord-015516-hx7ktq8j 51 19 patients patient NNS cord-015516-hx7ktq8j 51 20 were be VBD cord-015516-hx7ktq8j 51 21 more more RBR cord-015516-hx7ktq8j 51 22 likely likely JJ cord-015516-hx7ktq8j 51 23 to to TO cord-015516-hx7ktq8j 51 24 have have VB cord-015516-hx7ktq8j 51 25 single single JJ cord-015516-hx7ktq8j 51 26 lesions lesion NNS cord-015516-hx7ktq8j 51 27 and and CC cord-015516-hx7ktq8j 51 28 had have VBD cord-015516-hx7ktq8j 51 29 to to TO cord-015516-hx7ktq8j 51 30 be be VB cord-015516-hx7ktq8j 51 31 considered consider VBN cord-015516-hx7ktq8j 51 32 capable capable JJ cord-015516-hx7ktq8j 51 33 of of IN cord-015516-hx7ktq8j 51 34 surviving survive VBG cord-015516-hx7ktq8j 51 35 the the DT cord-015516-hx7ktq8j 51 36 procedure procedure NN cord-015516-hx7ktq8j 51 37 ) ) -RRB- cord-015516-hx7ktq8j 51 38 , , , cord-015516-hx7ktq8j 51 39 the the DT cord-015516-hx7ktq8j 51 40 availability availability NN cord-015516-hx7ktq8j 51 41 of of IN cord-015516-hx7ktq8j 51 42 an an DT cord-015516-hx7ktq8j 51 43 aggressive aggressive JJ cord-015516-hx7ktq8j 51 44 neurosurgical neurosurgical JJ cord-015516-hx7ktq8j 51 45 colleague colleague NN cord-015516-hx7ktq8j 51 46 may may MD cord-015516-hx7ktq8j 51 47 also also RB cord-015516-hx7ktq8j 51 48 be be VB cord-015516-hx7ktq8j 51 49 invaluable invaluable JJ cord-015516-hx7ktq8j 51 50 in in IN cord-015516-hx7ktq8j 51 51 improving improve VBG cord-015516-hx7ktq8j 51 52 survival survival NN cord-015516-hx7ktq8j 51 53 rates rate NNS cord-015516-hx7ktq8j 51 54 for for IN cord-015516-hx7ktq8j 51 55 this this DT cord-015516-hx7ktq8j 51 56 devastating devastating JJ cord-015516-hx7ktq8j 51 57 infection infection NN cord-015516-hx7ktq8j 51 58 . . . cord-015516-hx7ktq8j 52 1 Crabtree Crabtree NNP cord-015516-hx7ktq8j 52 2 JH JH NNP cord-015516-hx7ktq8j 52 3 , , , cord-015516-hx7ktq8j 52 4 Burchette Burchette NNP cord-015516-hx7ktq8j 52 5 RJ RJ NNP cord-015516-hx7ktq8j 52 6 . . . cord-015516-hx7ktq8j 53 1 Surgical surgical JJ cord-015516-hx7ktq8j 53 2 salvage salvage NN cord-015516-hx7ktq8j 53 3 of of IN cord-015516-hx7ktq8j 53 4 peritoneal peritoneal JJ cord-015516-hx7ktq8j 53 5 dialysis dialysis NN cord-015516-hx7ktq8j 53 6 catheters catheter NNS cord-015516-hx7ktq8j 53 7 from from IN cord-015516-hx7ktq8j 53 8 chronic chronic JJ cord-015516-hx7ktq8j 53 9 exit exit NN cord-015516-hx7ktq8j 53 10 - - HYPH cord-015516-hx7ktq8j 53 11 site site NN cord-015516-hx7ktq8j 53 12 and and CC cord-015516-hx7ktq8j 53 13 tunnel tunnel NN cord-015516-hx7ktq8j 53 14 infections infection NNS cord-015516-hx7ktq8j 53 15 . . . cord-015516-hx7ktq8j 54 1 Am be VBP cord-015516-hx7ktq8j 54 2 J J NNP cord-015516-hx7ktq8j 54 3 Surg Surg NNP cord-015516-hx7ktq8j 54 4 2005 2005 CD cord-015516-hx7ktq8j 54 5 ; ; : cord-015516-hx7ktq8j 54 6 190:4 190:4 CD cord-015516-hx7ktq8j 54 7 - - SYM cord-015516-hx7ktq8j 54 8 8 8 CD cord-015516-hx7ktq8j 54 9 . . . cord-015516-hx7ktq8j 55 1 In in IN cord-015516-hx7ktq8j 55 2 patients patient NNS cord-015516-hx7ktq8j 55 3 with with IN cord-015516-hx7ktq8j 55 4 chronic chronic JJ cord-015516-hx7ktq8j 55 5 infections infection NNS cord-015516-hx7ktq8j 55 6 involving involve VBG cord-015516-hx7ktq8j 55 7 the the DT cord-015516-hx7ktq8j 55 8 exit exit NN cord-015516-hx7ktq8j 55 9 site site NN cord-015516-hx7ktq8j 55 10 or or CC cord-015516-hx7ktq8j 55 11 tunnel tunnel NN cord-015516-hx7ktq8j 55 12 portion portion NN cord-015516-hx7ktq8j 55 13 of of IN cord-015516-hx7ktq8j 55 14 peritoneal peritoneal JJ cord-015516-hx7ktq8j 55 15 dialysis dialysis NN cord-015516-hx7ktq8j 55 16 catheters catheter NNS cord-015516-hx7ktq8j 55 17 , , , cord-015516-hx7ktq8j 55 18 treatment treatment NN cord-015516-hx7ktq8j 55 19 with with IN cord-015516-hx7ktq8j 55 20 antibiotics antibiotic NNS cord-015516-hx7ktq8j 55 21 and and CC cord-015516-hx7ktq8j 55 22 local local JJ cord-015516-hx7ktq8j 55 23 care care NN cord-015516-hx7ktq8j 55 24 is be VBZ cord-015516-hx7ktq8j 55 25 often often RB cord-015516-hx7ktq8j 55 26 unsuccessful unsuccessful JJ cord-015516-hx7ktq8j 55 27 . . . cord-015516-hx7ktq8j 56 1 In in IN cord-015516-hx7ktq8j 56 2 such such JJ cord-015516-hx7ktq8j 56 3 cases case NNS cord-015516-hx7ktq8j 56 4 , , , cord-015516-hx7ktq8j 56 5 removal removal NN cord-015516-hx7ktq8j 56 6 of of IN cord-015516-hx7ktq8j 56 7 the the DT cord-015516-hx7ktq8j 56 8 catheter catheter NN cord-015516-hx7ktq8j 56 9 is be VBZ cord-015516-hx7ktq8j 56 10 usually usually RB cord-015516-hx7ktq8j 56 11 recommended recommend VBN cord-015516-hx7ktq8j 56 12 . . . cord-015516-hx7ktq8j 57 1 One one CD cord-015516-hx7ktq8j 57 2 less less RBR cord-015516-hx7ktq8j 57 3 drastic drastic JJ cord-015516-hx7ktq8j 57 4 method method NN cord-015516-hx7ktq8j 57 5 that that WDT cord-015516-hx7ktq8j 57 6 allows allow VBZ cord-015516-hx7ktq8j 57 7 salvage salvage NN cord-015516-hx7ktq8j 57 8 of of IN cord-015516-hx7ktq8j 57 9 the the DT cord-015516-hx7ktq8j 57 10 infected infected JJ cord-015516-hx7ktq8j 57 11 catheter catheter NN cord-015516-hx7ktq8j 57 12 - - HYPH cord-015516-hx7ktq8j 57 13 unroofing unroofing NN cord-015516-hx7ktq8j 57 14 of of IN cord-015516-hx7ktq8j 57 15 the the DT cord-015516-hx7ktq8j 57 16 tunnel tunnel NN cord-015516-hx7ktq8j 57 17 tract tract NN cord-015516-hx7ktq8j 57 18 and and CC cord-015516-hx7ktq8j 57 19 removal removal NN cord-015516-hx7ktq8j 57 20 of of IN cord-015516-hx7ktq8j 57 21 the the DT cord-015516-hx7ktq8j 57 22 superficial superficial JJ cord-015516-hx7ktq8j 57 23 catheter catheter NN cord-015516-hx7ktq8j 57 24 cuff cuff NN cord-015516-hx7ktq8j 57 25 - - : cord-015516-hx7ktq8j 57 26 has have VBZ cord-015516-hx7ktq8j 57 27 been be VBN cord-015516-hx7ktq8j 57 28 used use VBN cord-015516-hx7ktq8j 57 29 , , , cord-015516-hx7ktq8j 57 30 but but CC cord-015516-hx7ktq8j 57 31 published publish VBN cord-015516-hx7ktq8j 57 32 evidence evidence NN cord-015516-hx7ktq8j 57 33 of of IN cord-015516-hx7ktq8j 57 34 benefit benefit NN cord-015516-hx7ktq8j 57 35 has have VBZ cord-015516-hx7ktq8j 57 36 been be VBN cord-015516-hx7ktq8j 57 37 scanty scanty JJ cord-015516-hx7ktq8j 57 38 . . . cord-015516-hx7ktq8j 58 1 This this DT cord-015516-hx7ktq8j 58 2 procedure procedure NN cord-015516-hx7ktq8j 58 3 was be VBD cord-015516-hx7ktq8j 58 4 used use VBN cord-015516-hx7ktq8j 58 5 by by IN cord-015516-hx7ktq8j 58 6 Crabtree Crabtree NNP cord-015516-hx7ktq8j 58 7 and and CC cord-015516-hx7ktq8j 58 8 Burchette Burchette NNP cord-015516-hx7ktq8j 58 9 in in IN cord-015516-hx7ktq8j 58 10 13 13 CD cord-015516-hx7ktq8j 58 11 consecutive consecutive JJ cord-015516-hx7ktq8j 58 12 patients patient NNS cord-015516-hx7ktq8j 58 13 with with IN cord-015516-hx7ktq8j 58 14 chronic chronic JJ cord-015516-hx7ktq8j 58 15 peritoneal peritoneal JJ cord-015516-hx7ktq8j 58 16 dialysis dialysis NN cord-015516-hx7ktq8j 58 17 catheter catheter NN cord-015516-hx7ktq8j 58 18 infections infection NNS cord-015516-hx7ktq8j 58 19 that that WDT cord-015516-hx7ktq8j 58 20 had have VBD cord-015516-hx7ktq8j 58 21 been be VBN cord-015516-hx7ktq8j 58 22 present present JJ cord-015516-hx7ktq8j 58 23 for for IN cord-015516-hx7ktq8j 58 24 a a DT cord-015516-hx7ktq8j 58 25 mean mean JJ cord-015516-hx7ktq8j 58 26 duration duration NN cord-015516-hx7ktq8j 58 27 of of IN cord-015516-hx7ktq8j 58 28 3.2 3.2 CD cord-015516-hx7ktq8j 58 29 months month NNS cord-015516-hx7ktq8j 58 30 , , , cord-015516-hx7ktq8j 58 31 with with IN cord-015516-hx7ktq8j 58 32 successful successful JJ cord-015516-hx7ktq8j 58 33 results result NNS cord-015516-hx7ktq8j 58 34 for for IN cord-015516-hx7ktq8j 58 35 all all DT cord-015516-hx7ktq8j 58 36 13 13 CD cord-015516-hx7ktq8j 58 37 . . . cord-015516-hx7ktq8j 59 1 The the DT cord-015516-hx7ktq8j 59 2 procedure procedure NN cord-015516-hx7ktq8j 59 3 consisted consist VBD cord-015516-hx7ktq8j 59 4 of of IN cord-015516-hx7ktq8j 59 5 excision excision NN cord-015516-hx7ktq8j 59 6 , , , cord-015516-hx7ktq8j 59 7 by by IN cord-015516-hx7ktq8j 59 8 shaving shaving NN cord-015516-hx7ktq8j 59 9 , , , cord-015516-hx7ktq8j 59 10 of of IN cord-015516-hx7ktq8j 59 11 the the DT cord-015516-hx7ktq8j 59 12 superficial superficial JJ cord-015516-hx7ktq8j 59 13 cuff cuff NN cord-015516-hx7ktq8j 59 14 after after IN cord-015516-hx7ktq8j 59 15 its -PRON- PRP$ cord-015516-hx7ktq8j 59 16 identification identification NN cord-015516-hx7ktq8j 59 17 and and CC cord-015516-hx7ktq8j 59 18 mobilization mobilization NN cord-015516-hx7ktq8j 59 19 through through IN cord-015516-hx7ktq8j 59 20 an an DT cord-015516-hx7ktq8j 59 21 incision incision NN cord-015516-hx7ktq8j 59 22 along along IN cord-015516-hx7ktq8j 59 23 the the DT cord-015516-hx7ktq8j 59 24 course course NN cord-015516-hx7ktq8j 59 25 of of IN cord-015516-hx7ktq8j 59 26 the the DT cord-015516-hx7ktq8j 59 27 catheter catheter NN cord-015516-hx7ktq8j 59 28 . . . cord-015516-hx7ktq8j 60 1 The the DT cord-015516-hx7ktq8j 60 2 exit exit NN cord-015516-hx7ktq8j 60 3 - - HYPH cord-015516-hx7ktq8j 60 4 site site NN cord-015516-hx7ktq8j 60 5 skin skin NN cord-015516-hx7ktq8j 60 6 and and CC cord-015516-hx7ktq8j 60 7 all all DT cord-015516-hx7ktq8j 60 8 inflammatory inflammatory JJ cord-015516-hx7ktq8j 60 9 tissue tissue NN cord-015516-hx7ktq8j 60 10 were be VBD cord-015516-hx7ktq8j 60 11 excised excise VBN cord-015516-hx7ktq8j 60 12 . . . cord-015516-hx7ktq8j 61 1 The the DT cord-015516-hx7ktq8j 61 2 catheter catheter NN cord-015516-hx7ktq8j 61 3 and and CC cord-015516-hx7ktq8j 61 4 shaved shave VBN cord-015516-hx7ktq8j 61 5 tubing tubing NN cord-015516-hx7ktq8j 61 6 segment segment NN cord-015516-hx7ktq8j 61 7 were be VBD cord-015516-hx7ktq8j 61 8 moved move VBN cord-015516-hx7ktq8j 61 9 out out IN cord-015516-hx7ktq8j 61 10 of of IN cord-015516-hx7ktq8j 61 11 the the DT cord-015516-hx7ktq8j 61 12 wound wound NN cord-015516-hx7ktq8j 61 13 and and CC cord-015516-hx7ktq8j 61 14 secured secure VBN cord-015516-hx7ktq8j 61 15 to to IN cord-015516-hx7ktq8j 61 16 the the DT cord-015516-hx7ktq8j 61 17 adjacent adjacent JJ cord-015516-hx7ktq8j 61 18 skin skin NN cord-015516-hx7ktq8j 61 19 surface surface NN cord-015516-hx7ktq8j 61 20 with with IN cord-015516-hx7ktq8j 61 21 tincture tincture NN cord-015516-hx7ktq8j 61 22 of of IN cord-015516-hx7ktq8j 61 23 benzoin benzoin NN cord-015516-hx7ktq8j 61 24 and and CC cord-015516-hx7ktq8j 61 25 sterile sterile JJ cord-015516-hx7ktq8j 61 26 adhesive adhesive JJ cord-015516-hx7ktq8j 61 27 strips strip NNS cord-015516-hx7ktq8j 61 28 . . . cord-015516-hx7ktq8j 62 1 The the DT cord-015516-hx7ktq8j 62 2 wound wound NN cord-015516-hx7ktq8j 62 3 was be VBD cord-015516-hx7ktq8j 62 4 packed pack VBN cord-015516-hx7ktq8j 62 5 open open JJ cord-015516-hx7ktq8j 62 6 and and CC cord-015516-hx7ktq8j 62 7 allowed allow VBN cord-015516-hx7ktq8j 62 8 to to TO cord-015516-hx7ktq8j 62 9 heal heal VB cord-015516-hx7ktq8j 62 10 . . . cord-015516-hx7ktq8j 63 1 Peritoneal peritoneal JJ cord-015516-hx7ktq8j 63 2 dialysis dialysis NN cord-015516-hx7ktq8j 63 3 was be VBD cord-015516-hx7ktq8j 63 4 allowed allow VBN cord-015516-hx7ktq8j 63 5 immediately immediately RB cord-015516-hx7ktq8j 63 6 , , , cord-015516-hx7ktq8j 63 7 and and CC cord-015516-hx7ktq8j 63 8 antibiotics antibiotic NNS cord-015516-hx7ktq8j 63 9 were be VBD cord-015516-hx7ktq8j 63 10 administered administer VBN cord-015516-hx7ktq8j 63 11 orally orally RB cord-015516-hx7ktq8j 63 12 for for IN cord-015516-hx7ktq8j 63 13 2 2 CD cord-015516-hx7ktq8j 63 14 - - SYM cord-015516-hx7ktq8j 63 15 4 4 CD cord-015516-hx7ktq8j 63 16 weeks week NNS cord-015516-hx7ktq8j 63 17 . . . cord-015516-hx7ktq8j 64 1 Wound wound JJ cord-015516-hx7ktq8j 64 2 healing healing NN cord-015516-hx7ktq8j 64 3 was be VBD cord-015516-hx7ktq8j 64 4 complete complete JJ cord-015516-hx7ktq8j 64 5 after after IN cord-015516-hx7ktq8j 64 6 a a DT cord-015516-hx7ktq8j 64 7 mean mean JJ cord-015516-hx7ktq8j 64 8 period period NN cord-015516-hx7ktq8j 64 9 of of IN cord-015516-hx7ktq8j 64 10 1.4 1.4 CD cord-015516-hx7ktq8j 64 11 months month NNS cord-015516-hx7ktq8j 64 12 ( ( -LRB- cord-015516-hx7ktq8j 64 13 range range NN cord-015516-hx7ktq8j 64 14 , , , cord-015516-hx7ktq8j 64 15 0.9 0.9 CD cord-015516-hx7ktq8j 64 16 - - SYM cord-015516-hx7ktq8j 64 17 2.2 2.2 CD cord-015516-hx7ktq8j 64 18 months month NNS cord-015516-hx7ktq8j 64 19 ) ) -RRB- cord-015516-hx7ktq8j 64 20 . . . cord-015516-hx7ktq8j 65 1 During during IN cord-015516-hx7ktq8j 65 2 a a DT cord-015516-hx7ktq8j 65 3 mean mean JJ cord-015516-hx7ktq8j 65 4 follow follow NN cord-015516-hx7ktq8j 65 5 - - HYPH cord-015516-hx7ktq8j 65 6 up up NN cord-015516-hx7ktq8j 65 7 period period NN cord-015516-hx7ktq8j 65 8 of of IN cord-015516-hx7ktq8j 65 9 18.2 18.2 CD cord-015516-hx7ktq8j 65 10 months month NNS cord-015516-hx7ktq8j 65 11 , , , cord-015516-hx7ktq8j 65 12 2 2 CD cord-015516-hx7ktq8j 65 13 persons person NNS cord-015516-hx7ktq8j 65 14 with with IN cord-015516-hx7ktq8j 65 15 nasal nasal NN cord-015516-hx7ktq8j 65 16 carriage carriage NN cord-015516-hx7ktq8j 65 17 of of IN cord-015516-hx7ktq8j 65 18 S. S. NNP cord-015516-hx7ktq8j 65 19 aureus aureus NN cord-015516-hx7ktq8j 65 20 developed develop VBD cord-015516-hx7ktq8j 65 21 infection infection NN cord-015516-hx7ktq8j 65 22 involving involve VBG cord-015516-hx7ktq8j 65 23 the the DT cord-015516-hx7ktq8j 65 24 deep deep JJ cord-015516-hx7ktq8j 65 25 cuff cuff NN cord-015516-hx7ktq8j 65 26 ( ( -LRB- cord-015516-hx7ktq8j 65 27 at at IN cord-015516-hx7ktq8j 65 28 months month NNS cord-015516-hx7ktq8j 65 29 8.9 8.9 CD cord-015516-hx7ktq8j 65 30 and and CC cord-015516-hx7ktq8j 65 31 33.7 33.7 CD cord-015516-hx7ktq8j 65 32 ) ) -RRB- cord-015516-hx7ktq8j 65 33 . . . cord-015516-hx7ktq8j 66 1 Three three CD cord-015516-hx7ktq8j 66 2 patients patient NNS cord-015516-hx7ktq8j 66 3 subsequently subsequently RB cord-015516-hx7ktq8j 66 4 had have VBD cord-015516-hx7ktq8j 66 5 their -PRON- PRP$ cord-015516-hx7ktq8j 66 6 catheters catheter NNS cord-015516-hx7ktq8j 66 7 removed remove VBN cord-015516-hx7ktq8j 66 8 because because IN cord-015516-hx7ktq8j 66 9 of of IN cord-015516-hx7ktq8j 66 10 peritonitis peritonitis NN cord-015516-hx7ktq8j 66 11 without without IN cord-015516-hx7ktq8j 66 12 exit exit NN cord-015516-hx7ktq8j 66 13 - - HYPH cord-015516-hx7ktq8j 66 14 site site NN cord-015516-hx7ktq8j 66 15 or or CC cord-015516-hx7ktq8j 66 16 tunnel tunnel NN cord-015516-hx7ktq8j 66 17 infection infection NN cord-015516-hx7ktq8j 66 18 at at IN cord-015516-hx7ktq8j 66 19 months month NNS cord-015516-hx7ktq8j 66 20 8 8 CD cord-015516-hx7ktq8j 66 21 - - SYM cord-015516-hx7ktq8j 66 22 11 11 CD cord-015516-hx7ktq8j 66 23 . . . cord-015516-hx7ktq8j 67 1 This this DT cord-015516-hx7ktq8j 67 2 procedure procedure NN cord-015516-hx7ktq8j 67 3 - - : cord-015516-hx7ktq8j 67 4 at at RB cord-015516-hx7ktq8j 67 5 least least JJS cord-015516-hx7ktq8j 67 6 , , , cord-015516-hx7ktq8j 67 7 as as IN cord-015516-hx7ktq8j 67 8 performed perform VBN cord-015516-hx7ktq8j 67 9 by by IN cord-015516-hx7ktq8j 67 10 this this DT cord-015516-hx7ktq8j 67 11 team team NN cord-015516-hx7ktq8j 67 12 - - : cord-015516-hx7ktq8j 67 13 appears appear VBZ cord-015516-hx7ktq8j 67 14 to to TO cord-015516-hx7ktq8j 67 15 be be VB cord-015516-hx7ktq8j 67 16 a a DT cord-015516-hx7ktq8j 67 17 highly highly RB cord-015516-hx7ktq8j 67 18 effective effective JJ cord-015516-hx7ktq8j 67 19 means mean NNS cord-015516-hx7ktq8j 67 20 of of IN cord-015516-hx7ktq8j 67 21 catheter catheter NN cord-015516-hx7ktq8j 67 22 preservation preservation NN cord-015516-hx7ktq8j 67 23 that that WDT cord-015516-hx7ktq8j 67 24 allows allow VBZ cord-015516-hx7ktq8j 67 25 continuation continuation NN cord-015516-hx7ktq8j 67 26 of of IN cord-015516-hx7ktq8j 67 27 peritoneal peritoneal JJ cord-015516-hx7ktq8j 67 28 dialysis dialysis NN cord-015516-hx7ktq8j 67 29 without without IN cord-015516-hx7ktq8j 67 30 interruption interruption NN cord-015516-hx7ktq8j 67 31 . . . cord-015516-hx7ktq8j 68 1 Angiotensin angiotensin NN cord-015516-hx7ktq8j 68 2 - - HYPH cord-015516-hx7ktq8j 68 3 converting convert VBG cord-015516-hx7ktq8j 68 4 enzyme enzyme NN cord-015516-hx7ktq8j 68 5 2 2 CD cord-015516-hx7ktq8j 68 6 protects protect VBZ cord-015516-hx7ktq8j 68 7 from from IN cord-015516-hx7ktq8j 68 8 severe severe JJ cord-015516-hx7ktq8j 68 9 acute acute JJ cord-015516-hx7ktq8j 68 10 lung lung NN cord-015516-hx7ktq8j 68 11 failure failure NN cord-015516-hx7ktq8j 68 12 ACE1 ace1 CD cord-015516-hx7ktq8j 68 13 polymorphism polymorphism NN cord-015516-hx7ktq8j 68 14 and and CC cord-015516-hx7ktq8j 68 15 progression progression NN cord-015516-hx7ktq8j 68 16 of of IN cord-015516-hx7ktq8j 68 17 SARS SARS NNP cord-015516-hx7ktq8j 68 18 Aspergillosis Aspergillosis NNP cord-015516-hx7ktq8j 68 19 case case NN cord-015516-hx7ktq8j 68 20 - - HYPH cord-015516-hx7ktq8j 68 21 fatality fatality NN cord-015516-hx7ktq8j 68 22 rate rate NN cord-015516-hx7ktq8j 68 23 : : : cord-015516-hx7ktq8j 68 24 systematic systematic JJ cord-015516-hx7ktq8j 68 25 review review NN cord-015516-hx7ktq8j 68 26 of of IN cord-015516-hx7ktq8j 68 27 the the DT cord-015516-hx7ktq8j 68 28 literature literature NN