id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-348350-pac9ha4q	Martin-Blondel, G	Hydroxychloroquine in COVID-19 patients: what still needs to be known about the kinetics	2020-05-11		.txt	text/plain	1824	136	59	Different dosage regimens of hydroxychloroquine are used to manage COVID-19 patients, without information on the pharmacokinetics in this population.Blood samples (n=101) were collected from 57 COVID-19 patients for 7 days and concentrations were compared with simulated kinetic profiles.Hydroxychloroquine exposure is low and cannot be predicted by other populations. Because of the severity of COVID-19 and the pharmacokinetics of hydroxychloroquine in SLE patients [5] , a loading dose was rapidly included in the new hospital regimens to optimize drug distribution in tissues and more precisely in the lungs. For each regimen applied at the Toulouse University Hospital, an example of the expected kinetic profiles for a body weight of 80 kg (the median weight in our population) are presented in Figure 1 with the corresponding serum concentration for each patient.	./cache/cord-348350-pac9ha4q.txt	./txt/cord-348350-pac9ha4q.txt