id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260274-c3586tp6	Somers, Emily C	Tocilizumab for treatment of mechanically ventilated patients with COVID-19	2020-07-11		.txt	text/plain	3645	218	37	CONCLUSIONS: In this cohort of mechanically ventilated COVID-19 patients, tocilizumab was associated with lower mortality despite higher superinfection occurrence. At our institution, IL-6 blockade with tocilizumab is considered for patients with severe COVID-19 and suspected hyperinflammation based on rapidly worsening respiratory status and elevated inflammatory markers, with the majority of usage occurring in patients requiring mechanical ventilation. Using our COVID-19 Rapid Response Registry infrastructure, we performed an observational study of outcomes in patients with COVID-19 requiring mechanical ventilation, comparing those treated with tocilizumab with those who were not. In this observational, controlled study of patients with severe COVID-19 necessitating mechanical ventilation, receipt of tocilizumab was independently associated with improved survival. To date, the risk of superinfection in mechanically ventilated patients with severe COVID-19 remains poorly described and the incremental risk associated with a single dose of tocilizumab is not well characterized.	./cache/cord-260274-c3586tp6.txt	./txt/cord-260274-c3586tp6.txt