id sid tid token lemma pos cord-354827-ipg1vwmv 1 1 key key NN cord-354827-ipg1vwmv 1 2 : : : cord-354827-ipg1vwmv 1 3 cord-354827-ipg1vwmv cord-354827-ipg1vwmv NNP cord-354827-ipg1vwmv 1 4 authors author NNS cord-354827-ipg1vwmv 1 5 : : : cord-354827-ipg1vwmv 1 6 Baker Baker NNP cord-354827-ipg1vwmv 1 7 , , , cord-354827-ipg1vwmv 1 8 Stephen Stephen NNP cord-354827-ipg1vwmv 1 9 ; ; : cord-354827-ipg1vwmv 1 10 Favorov Favorov NNP cord-354827-ipg1vwmv 1 11 , , , cord-354827-ipg1vwmv 1 12 Michael Michael NNP cord-354827-ipg1vwmv 1 13 ; ; : cord-354827-ipg1vwmv 1 14 Dougan Dougan NNP cord-354827-ipg1vwmv 1 15 , , , cord-354827-ipg1vwmv 1 16 Gordon Gordon NNP cord-354827-ipg1vwmv 1 17 title title NN cord-354827-ipg1vwmv 1 18 : : : cord-354827-ipg1vwmv 2 1 Searching search VBG cord-354827-ipg1vwmv 2 2 for for IN cord-354827-ipg1vwmv 2 3 the the DT cord-354827-ipg1vwmv 2 4 elusive elusive JJ cord-354827-ipg1vwmv 2 5 typhoid typhoid NN cord-354827-ipg1vwmv 2 6 diagnostic diagnostic JJ cord-354827-ipg1vwmv 2 7 date date NN cord-354827-ipg1vwmv 3 1 : : : cord-354827-ipg1vwmv 3 2 2010 2010 CD cord-354827-ipg1vwmv 3 3 - - SYM cord-354827-ipg1vwmv 3 4 03 03 CD cord-354827-ipg1vwmv 3 5 - - HYPH cord-354827-ipg1vwmv 3 6 05 05 CD cord-354827-ipg1vwmv 3 7 journal journal NN cord-354827-ipg1vwmv 3 8 : : : cord-354827-ipg1vwmv 4 1 BMC BMC NNP cord-354827-ipg1vwmv 4 2 Infect infect VB cord-354827-ipg1vwmv 4 3 Dis Dis NNP cord-354827-ipg1vwmv 4 4 DOI doi NN cord-354827-ipg1vwmv 4 5 : : : cord-354827-ipg1vwmv 4 6 10.1186/1471 10.1186/1471 CD cord-354827-ipg1vwmv 4 7 - - HYPH cord-354827-ipg1vwmv 4 8 2334 2334 CD cord-354827-ipg1vwmv 4 9 - - HYPH cord-354827-ipg1vwmv 4 10 10 10 CD cord-354827-ipg1vwmv 4 11 - - SYM cord-354827-ipg1vwmv 4 12 45 45 CD cord-354827-ipg1vwmv 4 13 sha sha NNP cord-354827-ipg1vwmv 4 14 : : : cord-354827-ipg1vwmv 5 1 2a71668dd2b73cbbeb5005a2905688ed276603a9 2a71668dd2b73cbbeb5005a2905688ed276603a9 CD cord-354827-ipg1vwmv 5 2 doc_id doc_id CD cord-354827-ipg1vwmv 5 3 : : : cord-354827-ipg1vwmv 5 4 354827 354827 CD cord-354827-ipg1vwmv 5 5 cord_uid cord_uid NNS cord-354827-ipg1vwmv 5 6 : : : cord-354827-ipg1vwmv 6 1 ipg1vwmv ipg1vwmv DT cord-354827-ipg1vwmv 6 2 Typhoid typhoid NN cord-354827-ipg1vwmv 6 3 ( ( -LRB- cord-354827-ipg1vwmv 6 4 enteric enteric JJ cord-354827-ipg1vwmv 6 5 ) ) -RRB- cord-354827-ipg1vwmv 6 6 fever fever NN cord-354827-ipg1vwmv 6 7 is be VBZ cord-354827-ipg1vwmv 6 8 still still RB cord-354827-ipg1vwmv 6 9 a a DT cord-354827-ipg1vwmv 6 10 common common JJ cord-354827-ipg1vwmv 6 11 disease disease NN cord-354827-ipg1vwmv 6 12 in in IN cord-354827-ipg1vwmv 6 13 many many JJ cord-354827-ipg1vwmv 6 14 developing develop VBG cord-354827-ipg1vwmv 6 15 countries country NNS cord-354827-ipg1vwmv 6 16 but but CC cord-354827-ipg1vwmv 6 17 current current JJ cord-354827-ipg1vwmv 6 18 diagnostic diagnostic JJ cord-354827-ipg1vwmv 6 19 tests test NNS cord-354827-ipg1vwmv 6 20 are be VBP cord-354827-ipg1vwmv 6 21 inadequate inadequate JJ cord-354827-ipg1vwmv 6 22 . . . cord-354827-ipg1vwmv 7 1 Studies study NNS cord-354827-ipg1vwmv 7 2 on on IN cord-354827-ipg1vwmv 7 3 pathogenesis pathogenesis NN cord-354827-ipg1vwmv 7 4 and and CC cord-354827-ipg1vwmv 7 5 genomics genomic NNS cord-354827-ipg1vwmv 7 6 have have VBP cord-354827-ipg1vwmv 7 7 provided provide VBN cord-354827-ipg1vwmv 7 8 new new JJ cord-354827-ipg1vwmv 7 9 insight insight NN cord-354827-ipg1vwmv 7 10 into into IN cord-354827-ipg1vwmv 7 11 the the DT cord-354827-ipg1vwmv 7 12 organisms organism NNS cord-354827-ipg1vwmv 7 13 that that WDT cord-354827-ipg1vwmv 7 14 cause cause VBP cord-354827-ipg1vwmv 7 15 enteric enteric JJ cord-354827-ipg1vwmv 7 16 fever fever NN cord-354827-ipg1vwmv 7 17 . . . cord-354827-ipg1vwmv 8 1 Better well JJR cord-354827-ipg1vwmv 8 2 understanding understanding NN cord-354827-ipg1vwmv 8 3 of of IN cord-354827-ipg1vwmv 8 4 the the DT cord-354827-ipg1vwmv 8 5 microorganisms microorganism NNS cord-354827-ipg1vwmv 8 6 explains explain VBZ cord-354827-ipg1vwmv 8 7 , , , cord-354827-ipg1vwmv 8 8 in in IN cord-354827-ipg1vwmv 8 9 part part NN cord-354827-ipg1vwmv 8 10 , , , cord-354827-ipg1vwmv 8 11 why why WRB cord-354827-ipg1vwmv 8 12 our -PRON- PRP$ cord-354827-ipg1vwmv 8 13 current current JJ cord-354827-ipg1vwmv 8 14 typhoid typhoid NN cord-354827-ipg1vwmv 8 15 methodologies methodology NNS cord-354827-ipg1vwmv 8 16 are be VBP cord-354827-ipg1vwmv 8 17 limited limit VBN cord-354827-ipg1vwmv 8 18 in in IN cord-354827-ipg1vwmv 8 19 their -PRON- PRP$ cord-354827-ipg1vwmv 8 20 diagnostic diagnostic JJ cord-354827-ipg1vwmv 8 21 information information NN cord-354827-ipg1vwmv 8 22 and and CC cord-354827-ipg1vwmv 8 23 why why WRB cord-354827-ipg1vwmv 8 24 developing develop VBG cord-354827-ipg1vwmv 8 25 new new JJ cord-354827-ipg1vwmv 8 26 strategies strategy NNS cord-354827-ipg1vwmv 8 27 may may MD cord-354827-ipg1vwmv 8 28 be be VB cord-354827-ipg1vwmv 8 29 a a DT cord-354827-ipg1vwmv 8 30 considerable considerable JJ cord-354827-ipg1vwmv 8 31 challenge challenge NN cord-354827-ipg1vwmv 8 32 . . . cord-354827-ipg1vwmv 9 1 Here here RB cord-354827-ipg1vwmv 9 2 we -PRON- PRP cord-354827-ipg1vwmv 9 3 discuss discuss VBP cord-354827-ipg1vwmv 9 4 the the DT cord-354827-ipg1vwmv 9 5 current current JJ cord-354827-ipg1vwmv 9 6 position position NN cord-354827-ipg1vwmv 9 7 of of IN cord-354827-ipg1vwmv 9 8 typhoid typhoid NN cord-354827-ipg1vwmv 9 9 diagnostics diagnostic NNS cord-354827-ipg1vwmv 9 10 , , , cord-354827-ipg1vwmv 9 11 highlight highlight VB cord-354827-ipg1vwmv 9 12 the the DT cord-354827-ipg1vwmv 9 13 need need NN cord-354827-ipg1vwmv 9 14 for for IN cord-354827-ipg1vwmv 9 15 technological technological JJ cord-354827-ipg1vwmv 9 16 improvements improvement NNS cord-354827-ipg1vwmv 9 17 and and CC cord-354827-ipg1vwmv 9 18 suggest suggest VBP cord-354827-ipg1vwmv 9 19 potential potential JJ cord-354827-ipg1vwmv 9 20 ways way NNS cord-354827-ipg1vwmv 9 21 of of IN cord-354827-ipg1vwmv 9 22 advancing advance VBG cord-354827-ipg1vwmv 9 23 this this DT cord-354827-ipg1vwmv 9 24 area area NN cord-354827-ipg1vwmv 9 25 . . . cord-354827-ipg1vwmv 10 1 Enteric enteric JJ cord-354827-ipg1vwmv 10 2 ( ( -LRB- cord-354827-ipg1vwmv 10 3 typhoid typhoid NN cord-354827-ipg1vwmv 10 4 ) ) -RRB- cord-354827-ipg1vwmv 10 5 fever fever NN cord-354827-ipg1vwmv 10 6 remains remain VBZ cord-354827-ipg1vwmv 10 7 a a DT cord-354827-ipg1vwmv 10 8 common common JJ cord-354827-ipg1vwmv 10 9 disease disease NN cord-354827-ipg1vwmv 10 10 in in IN cord-354827-ipg1vwmv 10 11 many many JJ cord-354827-ipg1vwmv 10 12 parts part NNS cord-354827-ipg1vwmv 10 13 of of IN cord-354827-ipg1vwmv 10 14 the the DT cord-354827-ipg1vwmv 10 15 world world NN cord-354827-ipg1vwmv 10 16 where where WRB cord-354827-ipg1vwmv 10 17 access access NN cord-354827-ipg1vwmv 10 18 to to IN cord-354827-ipg1vwmv 10 19 clean clean JJ cord-354827-ipg1vwmv 10 20 water water NN cord-354827-ipg1vwmv 10 21 is be VBZ cord-354827-ipg1vwmv 10 22 limited limit VBN cord-354827-ipg1vwmv 10 23 . . . cord-354827-ipg1vwmv 11 1 In in IN cord-354827-ipg1vwmv 11 2 places place NNS cord-354827-ipg1vwmv 11 3 such such JJ cord-354827-ipg1vwmv 11 4 as as IN cord-354827-ipg1vwmv 11 5 India India NNP cord-354827-ipg1vwmv 11 6 , , , cord-354827-ipg1vwmv 11 7 Nepal Nepal NNP cord-354827-ipg1vwmv 11 8 , , , cord-354827-ipg1vwmv 11 9 Pakistan Pakistan NNP cord-354827-ipg1vwmv 11 10 , , , cord-354827-ipg1vwmv 11 11 Indonesia Indonesia NNP cord-354827-ipg1vwmv 11 12 and and CC cord-354827-ipg1vwmv 11 13 parts part NNS cord-354827-ipg1vwmv 11 14 of of IN cord-354827-ipg1vwmv 11 15 sub sub JJ cord-354827-ipg1vwmv 11 16 - - JJ cord-354827-ipg1vwmv 11 17 Saharan saharan JJ cord-354827-ipg1vwmv 11 18 Africa Africa NNP cord-354827-ipg1vwmv 11 19 typhoid typhoid NN cord-354827-ipg1vwmv 11 20 is be VBZ cord-354827-ipg1vwmv 11 21 still still RB cord-354827-ipg1vwmv 11 22 a a DT cord-354827-ipg1vwmv 11 23 substantial substantial JJ cord-354827-ipg1vwmv 11 24 public public JJ cord-354827-ipg1vwmv 11 25 health health NN cord-354827-ipg1vwmv 11 26 problem problem NN cord-354827-ipg1vwmv 11 27 [ [ -LRB- cord-354827-ipg1vwmv 11 28 1 1 CD cord-354827-ipg1vwmv 11 29 ] ] -RRB- cord-354827-ipg1vwmv 11 30 [ [ -LRB- cord-354827-ipg1vwmv 11 31 2 2 CD cord-354827-ipg1vwmv 11 32 ] ] -RRB- cord-354827-ipg1vwmv 11 33 [ [ -LRB- cord-354827-ipg1vwmv 11 34 3 3 CD cord-354827-ipg1vwmv 11 35 ] ] -RRB- cord-354827-ipg1vwmv 11 36 [ [ -LRB- cord-354827-ipg1vwmv 11 37 4 4 CD cord-354827-ipg1vwmv 11 38 ] ] -RRB- cord-354827-ipg1vwmv 11 39 . . . cord-354827-ipg1vwmv 12 1 In in IN cord-354827-ipg1vwmv 12 2 these these DT cord-354827-ipg1vwmv 12 3 areas area NNS cord-354827-ipg1vwmv 12 4 , , , cord-354827-ipg1vwmv 12 5 febrile febrile JJ cord-354827-ipg1vwmv 12 6 disease disease NN cord-354827-ipg1vwmv 12 7 is be VBZ cord-354827-ipg1vwmv 12 8 common common JJ cord-354827-ipg1vwmv 12 9 , , , cord-354827-ipg1vwmv 12 10 so so RB cord-354827-ipg1vwmv 12 11 accurate accurate JJ cord-354827-ipg1vwmv 12 12 diagnosis diagnosis NN cord-354827-ipg1vwmv 12 13 facilitates facilitate VBZ cord-354827-ipg1vwmv 12 14 treatment treatment NN cord-354827-ipg1vwmv 12 15 selection selection NN cord-354827-ipg1vwmv 12 16 , , , cord-354827-ipg1vwmv 12 17 particularly particularly RB cord-354827-ipg1vwmv 12 18 as as IN cord-354827-ipg1vwmv 12 19 antimicrobial antimicrobial JJ cord-354827-ipg1vwmv 12 20 resistance resistance NN cord-354827-ipg1vwmv 12 21 is be VBZ cord-354827-ipg1vwmv 12 22 emerging emerge VBG cord-354827-ipg1vwmv 12 23 [ [ -LRB- cord-354827-ipg1vwmv 12 24 5 5 CD cord-354827-ipg1vwmv 12 25 ] ] -RRB- cord-354827-ipg1vwmv 12 26 . . . cord-354827-ipg1vwmv 13 1 Enteric enteric JJ cord-354827-ipg1vwmv 13 2 fever fever NN cord-354827-ipg1vwmv 13 3 is be VBZ cord-354827-ipg1vwmv 13 4 an an DT cord-354827-ipg1vwmv 13 5 all all DT cord-354827-ipg1vwmv 13 6 encompassing encompassing JJ cord-354827-ipg1vwmv 13 7 term term NN cord-354827-ipg1vwmv 13 8 for for IN cord-354827-ipg1vwmv 13 9 the the DT cord-354827-ipg1vwmv 13 10 disease disease NN cord-354827-ipg1vwmv 13 11 caused cause VBN cord-354827-ipg1vwmv 13 12 by by IN cord-354827-ipg1vwmv 13 13 several several JJ cord-354827-ipg1vwmv 13 14 serovars serovar NNS cord-354827-ipg1vwmv 13 15 of of IN cord-354827-ipg1vwmv 13 16 Salmonella Salmonella NNP cord-354827-ipg1vwmv 13 17 enterica enterica NN cord-354827-ipg1vwmv 13 18 including include VBG cord-354827-ipg1vwmv 13 19 ( ( -LRB- cord-354827-ipg1vwmv 13 20 S. S. NNP cord-354827-ipg1vwmv 13 21 ) ) -RRB- cord-354827-ipg1vwmv 13 22 Typhi Typhi NNP cord-354827-ipg1vwmv 13 23 and and CC cord-354827-ipg1vwmv 13 24 ( ( -LRB- cord-354827-ipg1vwmv 13 25 S.)Paratyphi S.)Paratyphi NNPS cord-354827-ipg1vwmv 13 26 A. a. NN cord-354827-ipg1vwmv 14 1 Although although IN cord-354827-ipg1vwmv 14 2 globally globally RB cord-354827-ipg1vwmv 14 3 S. S. NNP cord-354827-ipg1vwmv 14 4 Typhi Typhi NNP cord-354827-ipg1vwmv 14 5 is be VBZ cord-354827-ipg1vwmv 14 6 the the DT cord-354827-ipg1vwmv 14 7 most most RBS cord-354827-ipg1vwmv 14 8 common common JJ cord-354827-ipg1vwmv 14 9 cause cause NN cord-354827-ipg1vwmv 14 10 , , , cord-354827-ipg1vwmv 14 11 S. S. NNP cord-354827-ipg1vwmv 14 12 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 15 1 A a DT cord-354827-ipg1vwmv 15 2 infections infection NNS cord-354827-ipg1vwmv 15 3 occur occur VBP cord-354827-ipg1vwmv 15 4 in in IN cord-354827-ipg1vwmv 15 5 significant significant JJ cord-354827-ipg1vwmv 15 6 numbers number NNS cord-354827-ipg1vwmv 15 7 in in IN cord-354827-ipg1vwmv 15 8 some some DT cord-354827-ipg1vwmv 15 9 parts part NNS cord-354827-ipg1vwmv 15 10 of of IN cord-354827-ipg1vwmv 15 11 the the DT cord-354827-ipg1vwmv 15 12 world world NN cord-354827-ipg1vwmv 15 13 and and CC cord-354827-ipg1vwmv 15 14 is be VBZ cord-354827-ipg1vwmv 15 15 often often RB cord-354827-ipg1vwmv 15 16 associated associate VBN cord-354827-ipg1vwmv 15 17 with with IN cord-354827-ipg1vwmv 15 18 travelers traveler NNS cord-354827-ipg1vwmv 15 19 [ [ -LRB- cord-354827-ipg1vwmv 15 20 6 6 CD cord-354827-ipg1vwmv 15 21 ] ] -RRB- cord-354827-ipg1vwmv 15 22 [ [ -LRB- cord-354827-ipg1vwmv 15 23 7 7 CD cord-354827-ipg1vwmv 15 24 ] ] -RRB- cord-354827-ipg1vwmv 15 25 [ [ -LRB- cord-354827-ipg1vwmv 15 26 8 8 CD cord-354827-ipg1vwmv 15 27 ] ] -RRB- cord-354827-ipg1vwmv 15 28 [ [ -LRB- cord-354827-ipg1vwmv 15 29 9 9 CD cord-354827-ipg1vwmv 15 30 ] ] -RRB- cord-354827-ipg1vwmv 15 31 . . . cord-354827-ipg1vwmv 16 1 In in IN cord-354827-ipg1vwmv 16 2 contrast contrast NN cord-354827-ipg1vwmv 16 3 , , , cord-354827-ipg1vwmv 16 4 S. S. NNP cord-354827-ipg1vwmv 16 5 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 16 6 B B NNP cord-354827-ipg1vwmv 16 7 and and CC cord-354827-ipg1vwmv 16 8 C C NNP cord-354827-ipg1vwmv 16 9 are be VBP cord-354827-ipg1vwmv 16 10 relatively relatively RB cord-354827-ipg1vwmv 16 11 uncommon uncommon JJ cord-354827-ipg1vwmv 16 12 . . . cord-354827-ipg1vwmv 17 1 This this DT cord-354827-ipg1vwmv 17 2 article article NN cord-354827-ipg1vwmv 17 3 focuses focus VBZ cord-354827-ipg1vwmv 17 4 specifically specifically RB cord-354827-ipg1vwmv 17 5 on on IN cord-354827-ipg1vwmv 17 6 S. S. NNP cord-354827-ipg1vwmv 17 7 Typhi Typhi NNP cord-354827-ipg1vwmv 17 8 and and CC cord-354827-ipg1vwmv 17 9 the the DT cord-354827-ipg1vwmv 17 10 disease disease NN cord-354827-ipg1vwmv 17 11 it -PRON- PRP cord-354827-ipg1vwmv 17 12 causes cause VBZ cord-354827-ipg1vwmv 17 13 ; ; : cord-354827-ipg1vwmv 17 14 typhoid typhoid NN cord-354827-ipg1vwmv 17 15 . . . cord-354827-ipg1vwmv 18 1 With with IN cord-354827-ipg1vwmv 18 2 respect respect NN cord-354827-ipg1vwmv 18 3 to to IN cord-354827-ipg1vwmv 18 4 other other JJ cord-354827-ipg1vwmv 18 5 invasive invasive JJ cord-354827-ipg1vwmv 18 6 Salmonella Salmonella NNP cord-354827-ipg1vwmv 18 7 , , , cord-354827-ipg1vwmv 18 8 S. S. NNP cord-354827-ipg1vwmv 18 9 Typhi Typhi NNP cord-354827-ipg1vwmv 18 10 causes cause VBZ cord-354827-ipg1vwmv 18 11 a a DT cord-354827-ipg1vwmv 18 12 greater great JJR cord-354827-ipg1vwmv 18 13 disease disease NN cord-354827-ipg1vwmv 18 14 burden burden NN cord-354827-ipg1vwmv 18 15 and and CC cord-354827-ipg1vwmv 18 16 there there EX cord-354827-ipg1vwmv 18 17 is be VBZ cord-354827-ipg1vwmv 18 18 a a DT cord-354827-ipg1vwmv 18 19 superior superior JJ cord-354827-ipg1vwmv 18 20 level level NN cord-354827-ipg1vwmv 18 21 of of IN cord-354827-ipg1vwmv 18 22 understanding understanding NN cord-354827-ipg1vwmv 18 23 of of IN cord-354827-ipg1vwmv 18 24 this this DT cord-354827-ipg1vwmv 18 25 organism organism NN cord-354827-ipg1vwmv 18 26 . . . cord-354827-ipg1vwmv 19 1 However however RB cord-354827-ipg1vwmv 19 2 , , , cord-354827-ipg1vwmv 19 3 all all DT cord-354827-ipg1vwmv 19 4 of of IN cord-354827-ipg1vwmv 19 5 the the DT cord-354827-ipg1vwmv 19 6 arguments argument NNS cord-354827-ipg1vwmv 19 7 presented present VBN cord-354827-ipg1vwmv 19 8 here here RB cord-354827-ipg1vwmv 19 9 are be VBP cord-354827-ipg1vwmv 19 10 poignant poignant JJ cord-354827-ipg1vwmv 19 11 for for IN cord-354827-ipg1vwmv 19 12 the the DT cord-354827-ipg1vwmv 19 13 diseases disease NNS cord-354827-ipg1vwmv 19 14 caused cause VBN cord-354827-ipg1vwmv 19 15 by by IN cord-354827-ipg1vwmv 19 16 other other JJ cord-354827-ipg1vwmv 19 17 human human JJ cord-354827-ipg1vwmv 19 18 invasive invasive JJ cord-354827-ipg1vwmv 19 19 Salmonella Salmonella NNP cord-354827-ipg1vwmv 19 20 pathovars pathovar NNS cord-354827-ipg1vwmv 19 21 . . . cord-354827-ipg1vwmv 20 1 Despite despite IN cord-354827-ipg1vwmv 20 2 WHO WHO NNP cord-354827-ipg1vwmv 20 3 recommendations recommendation VBZ cord-354827-ipg1vwmv 20 4 , , , cord-354827-ipg1vwmv 20 5 few few JJ cord-354827-ipg1vwmv 20 6 countries country NNS cord-354827-ipg1vwmv 20 7 have have VBP cord-354827-ipg1vwmv 20 8 taken take VBN cord-354827-ipg1vwmv 20 9 on on RP cord-354827-ipg1vwmv 20 10 typhoid typhoid NN cord-354827-ipg1vwmv 20 11 immunization immunization NN cord-354827-ipg1vwmv 20 12 [ [ -LRB- cord-354827-ipg1vwmv 20 13 10 10 CD cord-354827-ipg1vwmv 20 14 ] ] -RRB- cord-354827-ipg1vwmv 20 15 , , , cord-354827-ipg1vwmv 20 16 this this DT cord-354827-ipg1vwmv 20 17 is be VBZ cord-354827-ipg1vwmv 20 18 in in IN cord-354827-ipg1vwmv 20 19 part part NN cord-354827-ipg1vwmv 20 20 related relate VBN cord-354827-ipg1vwmv 20 21 to to IN cord-354827-ipg1vwmv 20 22 uncertainties uncertainty NNS cord-354827-ipg1vwmv 20 23 about about IN cord-354827-ipg1vwmv 20 24 disease disease NN cord-354827-ipg1vwmv 20 25 burden burden NN cord-354827-ipg1vwmv 20 26 . . . cord-354827-ipg1vwmv 21 1 The the DT cord-354827-ipg1vwmv 21 2 best good JJS cord-354827-ipg1vwmv 21 3 incidence incidence NN cord-354827-ipg1vwmv 21 4 assessment assessment NN cord-354827-ipg1vwmv 21 5 is be VBZ cord-354827-ipg1vwmv 21 6 based base VBN cord-354827-ipg1vwmv 21 7 on on IN cord-354827-ipg1vwmv 21 8 available available JJ cord-354827-ipg1vwmv 21 9 , , , cord-354827-ipg1vwmv 21 10 sparse sparse JJ cord-354827-ipg1vwmv 21 11 surveillance surveillance NN cord-354827-ipg1vwmv 21 12 information information NN cord-354827-ipg1vwmv 21 13 , , , cord-354827-ipg1vwmv 21 14 estimated estimate VBD cord-354827-ipg1vwmv 21 15 that that IN cord-354827-ipg1vwmv 21 16 in in IN cord-354827-ipg1vwmv 21 17 2000 2000 CD cord-354827-ipg1vwmv 21 18 there there EX cord-354827-ipg1vwmv 21 19 were be VBD cord-354827-ipg1vwmv 21 20 21,650,974 21,650,974 CD cord-354827-ipg1vwmv 21 21 illnesses illness NNS cord-354827-ipg1vwmv 21 22 and and CC cord-354827-ipg1vwmv 21 23 216,510 216,510 CD cord-354827-ipg1vwmv 21 24 deaths death NNS cord-354827-ipg1vwmv 21 25 due due JJ cord-354827-ipg1vwmv 21 26 to to IN cord-354827-ipg1vwmv 21 27 typhoid typhoid NN cord-354827-ipg1vwmv 21 28 and and CC cord-354827-ipg1vwmv 21 29 that that IN cord-354827-ipg1vwmv 21 30 paratyphoid paratyphoid NNP cord-354827-ipg1vwmv 21 31 caused cause VBD cord-354827-ipg1vwmv 21 32 5,412,744 5,412,744 CD cord-354827-ipg1vwmv 21 33 illnesses illness NNS cord-354827-ipg1vwmv 21 34 [ [ -LRB- cord-354827-ipg1vwmv 21 35 2 2 CD cord-354827-ipg1vwmv 21 36 ] ] -RRB- cord-354827-ipg1vwmv 21 37 . . . cord-354827-ipg1vwmv 22 1 These these DT cord-354827-ipg1vwmv 22 2 data datum NNS cord-354827-ipg1vwmv 22 3 is be VBZ cord-354827-ipg1vwmv 22 4 extrapolated extrapolate VBN cord-354827-ipg1vwmv 22 5 from from IN cord-354827-ipg1vwmv 22 6 limited limited JJ cord-354827-ipg1vwmv 22 7 studies study NNS cord-354827-ipg1vwmv 22 8 and and CC cord-354827-ipg1vwmv 22 9 such such JJ cord-354827-ipg1vwmv 22 10 figures figure NNS cord-354827-ipg1vwmv 22 11 , , , cord-354827-ipg1vwmv 22 12 therefore therefore RB cord-354827-ipg1vwmv 22 13 , , , cord-354827-ipg1vwmv 22 14 may may MD cord-354827-ipg1vwmv 22 15 be be VB cord-354827-ipg1vwmv 22 16 imprecise imprecise JJ cord-354827-ipg1vwmv 22 17 , , , cord-354827-ipg1vwmv 22 18 this this DT cord-354827-ipg1vwmv 22 19 is be VBZ cord-354827-ipg1vwmv 22 20 compounded compound VBN cord-354827-ipg1vwmv 22 21 by by IN cord-354827-ipg1vwmv 22 22 a a DT cord-354827-ipg1vwmv 22 23 lack lack NN cord-354827-ipg1vwmv 22 24 of of IN cord-354827-ipg1vwmv 22 25 accurate accurate JJ cord-354827-ipg1vwmv 22 26 diagnosis diagnosis NN cord-354827-ipg1vwmv 22 27 . . . cord-354827-ipg1vwmv 23 1 Therefore therefore RB cord-354827-ipg1vwmv 23 2 , , , cord-354827-ipg1vwmv 23 3 new new JJ cord-354827-ipg1vwmv 23 4 diagnostics diagnostic NNS cord-354827-ipg1vwmv 23 5 will will MD cord-354827-ipg1vwmv 23 6 play play VB cord-354827-ipg1vwmv 23 7 a a DT cord-354827-ipg1vwmv 23 8 key key JJ cord-354827-ipg1vwmv 23 9 role role NN cord-354827-ipg1vwmv 23 10 in in IN cord-354827-ipg1vwmv 23 11 decreasing decrease VBG cord-354827-ipg1vwmv 23 12 the the DT cord-354827-ipg1vwmv 23 13 incidence incidence NN cord-354827-ipg1vwmv 23 14 of of IN cord-354827-ipg1vwmv 23 15 typhoid typhoid NN cord-354827-ipg1vwmv 23 16 fever fever NN cord-354827-ipg1vwmv 23 17 , , , cord-354827-ipg1vwmv 23 18 by by IN cord-354827-ipg1vwmv 23 19 permitting permit VBG cord-354827-ipg1vwmv 23 20 governments government NNS cord-354827-ipg1vwmv 23 21 to to TO cord-354827-ipg1vwmv 23 22 accurately accurately RB cord-354827-ipg1vwmv 23 23 assess assess VB cord-354827-ipg1vwmv 23 24 the the DT cord-354827-ipg1vwmv 23 25 particular particular JJ cord-354827-ipg1vwmv 23 26 burden burden NN cord-354827-ipg1vwmv 23 27 of of IN cord-354827-ipg1vwmv 23 28 disease disease NN cord-354827-ipg1vwmv 23 29 and and CC cord-354827-ipg1vwmv 23 30 apply apply VB cord-354827-ipg1vwmv 23 31 vaccination vaccination NN cord-354827-ipg1vwmv 23 32 regimes regime NNS cord-354827-ipg1vwmv 23 33 accordingly accordingly RB cord-354827-ipg1vwmv 23 34 . . . cord-354827-ipg1vwmv 24 1 The the DT cord-354827-ipg1vwmv 24 2 development development NN cord-354827-ipg1vwmv 24 3 of of IN cord-354827-ipg1vwmv 24 4 cheap cheap JJ cord-354827-ipg1vwmv 24 5 and and CC cord-354827-ipg1vwmv 24 6 reliable reliable JJ cord-354827-ipg1vwmv 24 7 enteric enteric JJ cord-354827-ipg1vwmv 24 8 fever fever NN cord-354827-ipg1vwmv 24 9 diagnostics diagnostic NNS cord-354827-ipg1vwmv 24 10 would would MD cord-354827-ipg1vwmv 24 11 undoubtedly undoubtedly RB cord-354827-ipg1vwmv 24 12 benefit benefit VB cord-354827-ipg1vwmv 24 13 long long JJ cord-354827-ipg1vwmv 24 14 term term NN cord-354827-ipg1vwmv 24 15 disease disease NN cord-354827-ipg1vwmv 24 16 control control NN cord-354827-ipg1vwmv 24 17 and and CC cord-354827-ipg1vwmv 24 18 treatment treatment NN cord-354827-ipg1vwmv 24 19 . . . cord-354827-ipg1vwmv 25 1 Presently presently RB cord-354827-ipg1vwmv 25 2 , , , cord-354827-ipg1vwmv 25 3 direct direct JJ cord-354827-ipg1vwmv 25 4 blood blood NN cord-354827-ipg1vwmv 25 5 culture culture NN cord-354827-ipg1vwmv 25 6 , , , cord-354827-ipg1vwmv 25 7 followed follow VBN cord-354827-ipg1vwmv 25 8 by by IN cord-354827-ipg1vwmv 25 9 microbiological microbiological JJ cord-354827-ipg1vwmv 25 10 identification identification NN cord-354827-ipg1vwmv 25 11 is be VBZ cord-354827-ipg1vwmv 25 12 the the DT cord-354827-ipg1vwmv 25 13 gold gold NN cord-354827-ipg1vwmv 25 14 standard standard NN cord-354827-ipg1vwmv 25 15 , , , cord-354827-ipg1vwmv 25 16 any any DT cord-354827-ipg1vwmv 25 17 potential potential JJ cord-354827-ipg1vwmv 25 18 new new JJ cord-354827-ipg1vwmv 25 19 test test NN cord-354827-ipg1vwmv 25 20 needs need VBZ cord-354827-ipg1vwmv 25 21 to to TO cord-354827-ipg1vwmv 25 22 offer offer VB cord-354827-ipg1vwmv 25 23 a a DT cord-354827-ipg1vwmv 25 24 higher high JJR cord-354827-ipg1vwmv 25 25 diagnostic diagnostic JJ cord-354827-ipg1vwmv 25 26 rate rate NN cord-354827-ipg1vwmv 25 27 than than IN cord-354827-ipg1vwmv 25 28 this this DT cord-354827-ipg1vwmv 25 29 procedure procedure NN cord-354827-ipg1vwmv 25 30 [ [ -LRB- cord-354827-ipg1vwmv 25 31 11 11 CD cord-354827-ipg1vwmv 25 32 ] ] -RRB- cord-354827-ipg1vwmv 25 33 . . . cord-354827-ipg1vwmv 26 1 Blood blood NN cord-354827-ipg1vwmv 26 2 culturing culturing NN cord-354827-ipg1vwmv 26 3 of of IN cord-354827-ipg1vwmv 26 4 S. S. NNP cord-354827-ipg1vwmv 26 5 Typhi Typhi NNP cord-354827-ipg1vwmv 26 6 , , , cord-354827-ipg1vwmv 26 7 whilst whilst IN cord-354827-ipg1vwmv 26 8 considered consider VBN cord-354827-ipg1vwmv 26 9 " " `` cord-354827-ipg1vwmv 26 10 routine routine JJ cord-354827-ipg1vwmv 26 11 " " '' cord-354827-ipg1vwmv 26 12 , , , cord-354827-ipg1vwmv 26 13 is be VBZ cord-354827-ipg1vwmv 26 14 expensive expensive JJ cord-354827-ipg1vwmv 26 15 and and CC cord-354827-ipg1vwmv 26 16 requires require VBZ cord-354827-ipg1vwmv 26 17 specialist specialist JJ cord-354827-ipg1vwmv 26 18 facilities facility NNS cord-354827-ipg1vwmv 26 19 and and CC cord-354827-ipg1vwmv 26 20 personnel personnel NNS cord-354827-ipg1vwmv 26 21 . . . cord-354827-ipg1vwmv 27 1 Furthermore furthermore RB cord-354827-ipg1vwmv 27 2 , , , cord-354827-ipg1vwmv 27 3 S. S. NNP cord-354827-ipg1vwmv 27 4 Typhi Typhi NNP cord-354827-ipg1vwmv 27 5 and and CC cord-354827-ipg1vwmv 27 6 S. S. NNP cord-354827-ipg1vwmv 27 7 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 27 8 A A NNP cord-354827-ipg1vwmv 27 9 are be VBP cord-354827-ipg1vwmv 27 10 not not RB cord-354827-ipg1vwmv 27 11 always always RB cord-354827-ipg1vwmv 27 12 culturable culturable JJ cord-354827-ipg1vwmv 27 13 even even RB cord-354827-ipg1vwmv 27 14 if if IN cord-354827-ipg1vwmv 27 15 good good JJ cord-354827-ipg1vwmv 27 16 microbiological microbiological JJ cord-354827-ipg1vwmv 27 17 facilities facility NNS cord-354827-ipg1vwmv 27 18 are be VBP cord-354827-ipg1vwmv 27 19 available available JJ cord-354827-ipg1vwmv 27 20 . . . cord-354827-ipg1vwmv 28 1 Diagnostics diagnostic NNS cord-354827-ipg1vwmv 28 2 based base VBN cord-354827-ipg1vwmv 28 3 on on IN cord-354827-ipg1vwmv 28 4 serology serology NN cord-354827-ipg1vwmv 28 5 , , , cord-354827-ipg1vwmv 28 6 antigen antigen NN cord-354827-ipg1vwmv 28 7 detection detection NN cord-354827-ipg1vwmv 28 8 or or CC cord-354827-ipg1vwmv 28 9 DNA dna NN cord-354827-ipg1vwmv 28 10 are be VBP cord-354827-ipg1vwmv 28 11 available available JJ cord-354827-ipg1vwmv 28 12 but but CC cord-354827-ipg1vwmv 28 13 have have VBP cord-354827-ipg1vwmv 28 14 limitations limitation NNS cord-354827-ipg1vwmv 28 15 . . . cord-354827-ipg1vwmv 29 1 In in IN cord-354827-ipg1vwmv 29 2 the the DT cord-354827-ipg1vwmv 29 3 document document NN cord-354827-ipg1vwmv 29 4 entitled entitle VBN cord-354827-ipg1vwmv 29 5 ' ' '' cord-354827-ipg1vwmv 29 6 The the DT cord-354827-ipg1vwmv 29 7 diagnosis diagnosis NN cord-354827-ipg1vwmv 29 8 , , , cord-354827-ipg1vwmv 29 9 treatment treatment NN cord-354827-ipg1vwmv 29 10 and and CC cord-354827-ipg1vwmv 29 11 prevention prevention NN cord-354827-ipg1vwmv 29 12 of of IN cord-354827-ipg1vwmv 29 13 typhoid typhoid NNP cord-354827-ipg1vwmv 29 14 ' ' '' cord-354827-ipg1vwmv 29 15 , , , cord-354827-ipg1vwmv 29 16 the the DT cord-354827-ipg1vwmv 29 17 WHO WHO NNP cord-354827-ipg1vwmv 29 18 state state NN cord-354827-ipg1vwmv 29 19 that that IN cord-354827-ipg1vwmv 29 20 ' ' '' cord-354827-ipg1vwmv 29 21 the the DT cord-354827-ipg1vwmv 29 22 method method NN cord-354827-ipg1vwmv 29 23 used use VBN cord-354827-ipg1vwmv 29 24 as as IN cord-354827-ipg1vwmv 29 25 the the DT cord-354827-ipg1vwmv 29 26 gold gold NN cord-354827-ipg1vwmv 29 27 standard standard NN cord-354827-ipg1vwmv 29 28 for for IN cord-354827-ipg1vwmv 29 29 the the DT cord-354827-ipg1vwmv 29 30 laboratory laboratory NN cord-354827-ipg1vwmv 29 31 diagnosis diagnosis NN cord-354827-ipg1vwmv 29 32 of of IN cord-354827-ipg1vwmv 29 33 typhoid typhoid NN cord-354827-ipg1vwmv 29 34 should should MD cord-354827-ipg1vwmv 29 35 approach approach VB cord-354827-ipg1vwmv 29 36 100 100 CD cord-354827-ipg1vwmv 29 37 % % NN cord-354827-ipg1vwmv 29 38 each each DT cord-354827-ipg1vwmv 29 39 for for IN cord-354827-ipg1vwmv 29 40 sensitivity sensitivity NN cord-354827-ipg1vwmv 29 41 , , , cord-354827-ipg1vwmv 29 42 specificity specificity NN cord-354827-ipg1vwmv 29 43 , , , cord-354827-ipg1vwmv 29 44 and and CC cord-354827-ipg1vwmv 29 45 positive positive JJ cord-354827-ipg1vwmv 29 46 and and CC cord-354827-ipg1vwmv 29 47 negative negative JJ cord-354827-ipg1vwmv 29 48 predictive predictive JJ cord-354827-ipg1vwmv 29 49 values value NNS cord-354827-ipg1vwmv 29 50 ' ' '' cord-354827-ipg1vwmv 29 51 [ [ -LRB- cord-354827-ipg1vwmv 29 52 11 11 CD cord-354827-ipg1vwmv 29 53 ] ] -RRB- cord-354827-ipg1vwmv 29 54 . . . cord-354827-ipg1vwmv 30 1 However however RB cord-354827-ipg1vwmv 30 2 , , , cord-354827-ipg1vwmv 30 3 current current JJ cord-354827-ipg1vwmv 30 4 tests test NNS cord-354827-ipg1vwmv 30 5 need need VBP cord-354827-ipg1vwmv 30 6 significant significant JJ cord-354827-ipg1vwmv 30 7 improvement improvement NN cord-354827-ipg1vwmv 30 8 to to TO cord-354827-ipg1vwmv 30 9 reach reach VB cord-354827-ipg1vwmv 30 10 such such JJ cord-354827-ipg1vwmv 30 11 rigorous rigorous JJ cord-354827-ipg1vwmv 30 12 standards standard NNS cord-354827-ipg1vwmv 30 13 . . . cord-354827-ipg1vwmv 31 1 In in IN cord-354827-ipg1vwmv 31 2 view view NN cord-354827-ipg1vwmv 31 3 of of IN cord-354827-ipg1vwmv 31 4 these these DT cord-354827-ipg1vwmv 31 5 problems problem NNS cord-354827-ipg1vwmv 31 6 , , , cord-354827-ipg1vwmv 31 7 is be VBZ cord-354827-ipg1vwmv 31 8 the the DT cord-354827-ipg1vwmv 31 9 goal goal NN cord-354827-ipg1vwmv 31 10 set set VBN cord-354827-ipg1vwmv 31 11 by by IN cord-354827-ipg1vwmv 31 12 WHO who WP cord-354827-ipg1vwmv 31 13 achievable achievable JJ cord-354827-ipg1vwmv 31 14 and and CC cord-354827-ipg1vwmv 31 15 what what WP cord-354827-ipg1vwmv 31 16 are be VBP cord-354827-ipg1vwmv 31 17 the the DT cord-354827-ipg1vwmv 31 18 barriers barrier NNS cord-354827-ipg1vwmv 31 19 ? ? . cord-354827-ipg1vwmv 32 1 Significant significant JJ cord-354827-ipg1vwmv 32 2 advances advance NNS cord-354827-ipg1vwmv 32 3 have have VBP cord-354827-ipg1vwmv 32 4 been be VBN cord-354827-ipg1vwmv 32 5 made make VBN cord-354827-ipg1vwmv 32 6 in in IN cord-354827-ipg1vwmv 32 7 our -PRON- PRP$ cord-354827-ipg1vwmv 32 8 understanding understanding NN cord-354827-ipg1vwmv 32 9 of of IN cord-354827-ipg1vwmv 32 10 the the DT cord-354827-ipg1vwmv 32 11 biology biology NN cord-354827-ipg1vwmv 32 12 and and CC cord-354827-ipg1vwmv 32 13 genomics genomic NNS cord-354827-ipg1vwmv 32 14 of of IN cord-354827-ipg1vwmv 32 15 both both CC cord-354827-ipg1vwmv 32 16 S. S. NNP cord-354827-ipg1vwmv 32 17 Typhi Typhi NNP cord-354827-ipg1vwmv 32 18 and and CC cord-354827-ipg1vwmv 32 19 S. S. NNP cord-354827-ipg1vwmv 32 20 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 33 1 A a DT cord-354827-ipg1vwmv 33 2 [ [ -LRB- cord-354827-ipg1vwmv 33 3 12 12 CD cord-354827-ipg1vwmv 33 4 ] ] -RRB- cord-354827-ipg1vwmv 33 5 [ [ -LRB- cord-354827-ipg1vwmv 33 6 13 13 CD cord-354827-ipg1vwmv 33 7 ] ] -RRB- cord-354827-ipg1vwmv 34 1 [ [ -LRB- cord-354827-ipg1vwmv 34 2 14 14 CD cord-354827-ipg1vwmv 34 3 ] ] -RRB- cord-354827-ipg1vwmv 34 4 [ [ -LRB- cord-354827-ipg1vwmv 34 5 15 15 CD cord-354827-ipg1vwmv 34 6 ] ] -RRB- cord-354827-ipg1vwmv 34 7 . . . cord-354827-ipg1vwmv 35 1 Using use VBG cord-354827-ipg1vwmv 35 2 this this DT cord-354827-ipg1vwmv 35 3 information information NN cord-354827-ipg1vwmv 35 4 we -PRON- PRP cord-354827-ipg1vwmv 35 5 can can MD cord-354827-ipg1vwmv 35 6 reassess reassess VB cord-354827-ipg1vwmv 35 7 typhoid typhoid NN cord-354827-ipg1vwmv 35 8 diagnostics diagnostic NNS cord-354827-ipg1vwmv 35 9 and and CC cord-354827-ipg1vwmv 35 10 consider consider VB cord-354827-ipg1vwmv 35 11 the the DT cord-354827-ipg1vwmv 35 12 potential potential NN cord-354827-ipg1vwmv 35 13 and and CC cord-354827-ipg1vwmv 35 14 the the DT cord-354827-ipg1vwmv 35 15 limitations limitation NNS cord-354827-ipg1vwmv 35 16 of of IN cord-354827-ipg1vwmv 35 17 different different JJ cord-354827-ipg1vwmv 35 18 approaches approach NNS cord-354827-ipg1vwmv 35 19 ( ( -LRB- cord-354827-ipg1vwmv 35 20 Figure figure NN cord-354827-ipg1vwmv 35 21 1 1 CD cord-354827-ipg1vwmv 35 22 ) ) -RRB- cord-354827-ipg1vwmv 35 23 . . . cord-354827-ipg1vwmv 36 1 S. S. NNP cord-354827-ipg1vwmv 36 2 Typhi Typhi NNP cord-354827-ipg1vwmv 36 3 causes cause VBZ cord-354827-ipg1vwmv 36 4 typhoid typhoid NN cord-354827-ipg1vwmv 36 5 , , , cord-354827-ipg1vwmv 36 6 a a DT cord-354827-ipg1vwmv 36 7 fecal fecal JJ cord-354827-ipg1vwmv 36 8 - - HYPH cord-354827-ipg1vwmv 36 9 oral oral JJ cord-354827-ipg1vwmv 36 10 infection infection NN cord-354827-ipg1vwmv 36 11 leading lead VBG cord-354827-ipg1vwmv 36 12 to to IN cord-354827-ipg1vwmv 36 13 systemic systemic JJ cord-354827-ipg1vwmv 36 14 disease disease NN cord-354827-ipg1vwmv 36 15 ( ( -LRB- cord-354827-ipg1vwmv 36 16 Figure figure NN cord-354827-ipg1vwmv 36 17 2 2 CD cord-354827-ipg1vwmv 36 18 ) ) -RRB- cord-354827-ipg1vwmv 36 19 . . . cord-354827-ipg1vwmv 37 1 Tissue tissue NN cord-354827-ipg1vwmv 37 2 invasion invasion NN cord-354827-ipg1vwmv 37 3 drives drive VBZ cord-354827-ipg1vwmv 37 4 a a DT cord-354827-ipg1vwmv 37 5 potentially potentially RB cord-354827-ipg1vwmv 37 6 close close JJ cord-354827-ipg1vwmv 37 7 encounter encounter NN cord-354827-ipg1vwmv 37 8 with with IN cord-354827-ipg1vwmv 37 9 the the DT cord-354827-ipg1vwmv 37 10 immune immune JJ cord-354827-ipg1vwmv 37 11 system system NN cord-354827-ipg1vwmv 37 12 . . . cord-354827-ipg1vwmv 38 1 However however RB cord-354827-ipg1vwmv 38 2 , , , cord-354827-ipg1vwmv 38 3 S. S. NNP cord-354827-ipg1vwmv 38 4 Typhi Typhi NNP cord-354827-ipg1vwmv 38 5 is be VBZ cord-354827-ipg1vwmv 38 6 an an DT cord-354827-ipg1vwmv 38 7 immuno immuno JJ cord-354827-ipg1vwmv 38 8 - - HYPH cord-354827-ipg1vwmv 38 9 modulatory modulatory JJ cord-354827-ipg1vwmv 38 10 pathogen pathogen NN cord-354827-ipg1vwmv 38 11 which which WDT cord-354827-ipg1vwmv 38 12 goes go VBZ cord-354827-ipg1vwmv 38 13 to to IN cord-354827-ipg1vwmv 38 14 great great JJ cord-354827-ipg1vwmv 38 15 lengths length NNS cord-354827-ipg1vwmv 38 16 to to TO cord-354827-ipg1vwmv 38 17 avoid avoid VB cord-354827-ipg1vwmv 38 18 detection detection NN cord-354827-ipg1vwmv 38 19 by by IN cord-354827-ipg1vwmv 38 20 the the DT cord-354827-ipg1vwmv 38 21 immune immune JJ cord-354827-ipg1vwmv 38 22 host host NN cord-354827-ipg1vwmv 38 23 defenses defense NNS cord-354827-ipg1vwmv 38 24 . . . cord-354827-ipg1vwmv 39 1 The the DT cord-354827-ipg1vwmv 39 2 pathogenesis pathogenesis NN cord-354827-ipg1vwmv 39 3 of of IN cord-354827-ipg1vwmv 39 4 typhoid typhoid NN cord-354827-ipg1vwmv 39 5 fever fever NN cord-354827-ipg1vwmv 39 6 in in IN cord-354827-ipg1vwmv 39 7 man man NN cord-354827-ipg1vwmv 39 8 has have VBZ cord-354827-ipg1vwmv 39 9 received receive VBN cord-354827-ipg1vwmv 39 10 only only RB cord-354827-ipg1vwmv 39 11 limited limited JJ cord-354827-ipg1vwmv 39 12 attention attention NN cord-354827-ipg1vwmv 39 13 . . . cord-354827-ipg1vwmv 40 1 This this DT cord-354827-ipg1vwmv 40 2 is be VBZ cord-354827-ipg1vwmv 40 3 mainly mainly RB cord-354827-ipg1vwmv 40 4 because because IN cord-354827-ipg1vwmv 40 5 both both CC cord-354827-ipg1vwmv 40 6 S. S. NNP cord-354827-ipg1vwmv 40 7 Typhi Typhi NNP cord-354827-ipg1vwmv 40 8 and and CC cord-354827-ipg1vwmv 40 9 S. S. NNP cord-354827-ipg1vwmv 40 10 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 40 11 A A NNP cord-354827-ipg1vwmv 40 12 are be VBP cord-354827-ipg1vwmv 40 13 host host NN cord-354827-ipg1vwmv 40 14 - - HYPH cord-354827-ipg1vwmv 40 15 restricted restrict VBN cord-354827-ipg1vwmv 40 16 to to IN cord-354827-ipg1vwmv 40 17 humans human NNS cord-354827-ipg1vwmv 40 18 and and CC cord-354827-ipg1vwmv 40 19 there there EX cord-354827-ipg1vwmv 40 20 is be VBZ cord-354827-ipg1vwmv 40 21 no no DT cord-354827-ipg1vwmv 40 22 known know VBN cord-354827-ipg1vwmv 40 23 zoonotic zoonotic JJ cord-354827-ipg1vwmv 40 24 reservoir reservoir NN cord-354827-ipg1vwmv 40 25 . . . cord-354827-ipg1vwmv 41 1 Experimentation experimentation NN cord-354827-ipg1vwmv 41 2 using use VBG cord-354827-ipg1vwmv 41 3 surrogate surrogate JJ cord-354827-ipg1vwmv 41 4 hosts host NNS cord-354827-ipg1vwmv 41 5 and and CC cord-354827-ipg1vwmv 41 6 S. S. NNP cord-354827-ipg1vwmv 41 7 enterica enterica NNP cord-354827-ipg1vwmv 41 8 serotypes serotype NNS cord-354827-ipg1vwmv 41 9 ( ( -LRB- cord-354827-ipg1vwmv 41 10 e.g. e.g. RB cord-354827-ipg1vwmv 41 11 S. S. NNP cord-354827-ipg1vwmv 41 12 Typhimurium Typhimurium NNP cord-354827-ipg1vwmv 41 13 ) ) -RRB- cord-354827-ipg1vwmv 41 14 suggests suggest VBZ cord-354827-ipg1vwmv 41 15 that that IN cord-354827-ipg1vwmv 41 16 tissue tissue NN cord-354827-ipg1vwmv 41 17 invasion invasion NN cord-354827-ipg1vwmv 41 18 occurs occur VBZ cord-354827-ipg1vwmv 41 19 predominantly predominantly RB cord-354827-ipg1vwmv 41 20 through through IN cord-354827-ipg1vwmv 41 21 M M NNP cord-354827-ipg1vwmv 41 22 cells cell NNS cord-354827-ipg1vwmv 41 23 on on IN cord-354827-ipg1vwmv 41 24 Peyer Peyer NNP cord-354827-ipg1vwmv 41 25 's 's POS cord-354827-ipg1vwmv 41 26 patches patch NNS cord-354827-ipg1vwmv 41 27 in in IN cord-354827-ipg1vwmv 41 28 the the DT cord-354827-ipg1vwmv 41 29 terminal terminal JJ cord-354827-ipg1vwmv 41 30 ileum ileum NN cord-354827-ipg1vwmv 41 31 ( ( -LRB- cord-354827-ipg1vwmv 41 32 Figure figure NN cord-354827-ipg1vwmv 41 33 2 2 CD cord-354827-ipg1vwmv 41 34 ) ) -RRB- cord-354827-ipg1vwmv 41 35 [ [ -LRB- cord-354827-ipg1vwmv 41 36 16 16 CD cord-354827-ipg1vwmv 41 37 , , , cord-354827-ipg1vwmv 41 38 17 17 CD cord-354827-ipg1vwmv 41 39 ] ] -RRB- cord-354827-ipg1vwmv 41 40 . . . cord-354827-ipg1vwmv 42 1 Whilst whilst IN cord-354827-ipg1vwmv 42 2 these these DT cord-354827-ipg1vwmv 42 3 mechanisms mechanism NNS cord-354827-ipg1vwmv 42 4 have have VBP cord-354827-ipg1vwmv 42 5 never never RB cord-354827-ipg1vwmv 42 6 been be VBN cord-354827-ipg1vwmv 42 7 directly directly RB cord-354827-ipg1vwmv 42 8 proven prove VBN cord-354827-ipg1vwmv 42 9 for for IN cord-354827-ipg1vwmv 42 10 typhoid typhoid NN cord-354827-ipg1vwmv 42 11 , , , cord-354827-ipg1vwmv 42 12 it -PRON- PRP cord-354827-ipg1vwmv 42 13 is be VBZ cord-354827-ipg1vwmv 42 14 clear clear JJ cord-354827-ipg1vwmv 42 15 that that IN cord-354827-ipg1vwmv 42 16 S. S. NNP cord-354827-ipg1vwmv 42 17 Typhi Typhi NNP cord-354827-ipg1vwmv 42 18 has have VBZ cord-354827-ipg1vwmv 42 19 predominantly predominantly RB cord-354827-ipg1vwmv 42 20 forsaken forsake VBN cord-354827-ipg1vwmv 42 21 ongoing ongoing JJ cord-354827-ipg1vwmv 42 22 transmission transmission NN cord-354827-ipg1vwmv 42 23 in in IN cord-354827-ipg1vwmv 42 24 the the DT cord-354827-ipg1vwmv 42 25 habitat habitat NN cord-354827-ipg1vwmv 42 26 of of IN cord-354827-ipg1vwmv 42 27 the the DT cord-354827-ipg1vwmv 42 28 mammalian mammalian JJ cord-354827-ipg1vwmv 42 29 gastrointestinal gastrointestinal JJ cord-354827-ipg1vwmv 42 30 tract tract NN cord-354827-ipg1vwmv 42 31 of of IN cord-354827-ipg1vwmv 42 32 most most JJS cord-354827-ipg1vwmv 42 33 enteric enteric JJ cord-354827-ipg1vwmv 42 34 bacteria bacteria NNS cord-354827-ipg1vwmv 42 35 , , , cord-354827-ipg1vwmv 42 36 in in IN cord-354827-ipg1vwmv 42 37 the the DT cord-354827-ipg1vwmv 42 38 favor favor NN cord-354827-ipg1vwmv 42 39 of of IN cord-354827-ipg1vwmv 42 40 systemic systemic JJ cord-354827-ipg1vwmv 42 41 dissemination dissemination NN cord-354827-ipg1vwmv 42 42 . . . cord-354827-ipg1vwmv 43 1 The the DT cord-354827-ipg1vwmv 43 2 infection infection NN cord-354827-ipg1vwmv 43 3 eventually eventually RB cord-354827-ipg1vwmv 43 4 localizes localize VBZ cord-354827-ipg1vwmv 43 5 to to IN cord-354827-ipg1vwmv 43 6 the the DT cord-354827-ipg1vwmv 43 7 bone bone NN cord-354827-ipg1vwmv 43 8 marrow marrow NN cord-354827-ipg1vwmv 43 9 and and CC cord-354827-ipg1vwmv 43 10 ultimately ultimately RB cord-354827-ipg1vwmv 43 11 the the DT cord-354827-ipg1vwmv 43 12 gall gall NN cord-354827-ipg1vwmv 43 13 bladder bladder NN cord-354827-ipg1vwmv 43 14 where where WRB cord-354827-ipg1vwmv 43 15 the the DT cord-354827-ipg1vwmv 43 16 internal internal JJ cord-354827-ipg1vwmv 43 17 transmission transmission NN cord-354827-ipg1vwmv 43 18 cycle cycle NN cord-354827-ipg1vwmv 43 19 is be VBZ cord-354827-ipg1vwmv 43 20 completed complete VBN cord-354827-ipg1vwmv 43 21 as as IN cord-354827-ipg1vwmv 43 22 organisms organism NNS cord-354827-ipg1vwmv 43 23 are be VBP cord-354827-ipg1vwmv 43 24 shed shed VBN cord-354827-ipg1vwmv 43 25 in in IN cord-354827-ipg1vwmv 43 26 bile bile NN cord-354827-ipg1vwmv 43 27 , , , cord-354827-ipg1vwmv 43 28 potentially potentially RB cord-354827-ipg1vwmv 43 29 in in IN cord-354827-ipg1vwmv 43 30 high high JJ cord-354827-ipg1vwmv 43 31 numbers number NNS cord-354827-ipg1vwmv 43 32 ( ( -LRB- cord-354827-ipg1vwmv 43 33 Figure figure NN cord-354827-ipg1vwmv 43 34 2 2 CD cord-354827-ipg1vwmv 43 35 ) ) -RRB- cord-354827-ipg1vwmv 43 36 . . . cord-354827-ipg1vwmv 44 1 S. S. NNP cord-354827-ipg1vwmv 44 2 Typhi Typhi NNP cord-354827-ipg1vwmv 44 3 ( ( -LRB- cord-354827-ipg1vwmv 44 4 and and CC cord-354827-ipg1vwmv 44 5 S. S. NNP cord-354827-ipg1vwmv 44 6 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 44 7 A A NNP cord-354827-ipg1vwmv 44 8 ) ) -RRB- cord-354827-ipg1vwmv 44 9 is be VBZ cord-354827-ipg1vwmv 44 10 highly highly RB cord-354827-ipg1vwmv 44 11 clonal clonal JJ cord-354827-ipg1vwmv 44 12 , , , cord-354827-ipg1vwmv 44 13 exhibiting exhibit VBG cord-354827-ipg1vwmv 44 14 limited limited JJ cord-354827-ipg1vwmv 44 15 genome genome NN cord-354827-ipg1vwmv 44 16 variation variation NN cord-354827-ipg1vwmv 44 17 , , , cord-354827-ipg1vwmv 44 18 suggesting suggest VBG cord-354827-ipg1vwmv 44 19 this this DT cord-354827-ipg1vwmv 44 20 organism organism NN cord-354827-ipg1vwmv 44 21 is be VBZ cord-354827-ipg1vwmv 44 22 recently recently RB cord-354827-ipg1vwmv 44 23 evolved evolve VBN cord-354827-ipg1vwmv 44 24 [ [ -LRB- cord-354827-ipg1vwmv 44 25 15 15 CD cord-354827-ipg1vwmv 44 26 , , , cord-354827-ipg1vwmv 44 27 18 18 CD cord-354827-ipg1vwmv 44 28 ] ] -RRB- cord-354827-ipg1vwmv 44 29 . . . cord-354827-ipg1vwmv 45 1 The the DT cord-354827-ipg1vwmv 45 2 genetic genetic JJ cord-354827-ipg1vwmv 45 3 basis basis NN cord-354827-ipg1vwmv 45 4 of of IN cord-354827-ipg1vwmv 45 5 the the DT cord-354827-ipg1vwmv 45 6 switch switch NN cord-354827-ipg1vwmv 45 7 from from IN cord-354827-ipg1vwmv 45 8 an an DT cord-354827-ipg1vwmv 45 9 enteric enteric NN cord-354827-ipg1vwmv 45 10 to to IN cord-354827-ipg1vwmv 45 11 a a DT cord-354827-ipg1vwmv 45 12 systemic systemic JJ cord-354827-ipg1vwmv 45 13 lifestyle lifestyle NN cord-354827-ipg1vwmv 45 14 is be VBZ cord-354827-ipg1vwmv 45 15 imprinted imprint VBN cord-354827-ipg1vwmv 45 16 in in IN cord-354827-ipg1vwmv 45 17 its -PRON- PRP$ cord-354827-ipg1vwmv 45 18 genetic genetic JJ cord-354827-ipg1vwmv 45 19 makeup makeup NN cord-354827-ipg1vwmv 45 20 . . . cord-354827-ipg1vwmv 46 1 Many many JJ cord-354827-ipg1vwmv 46 2 genes gene NNS cord-354827-ipg1vwmv 46 3 associated associate VBN cord-354827-ipg1vwmv 46 4 with with IN cord-354827-ipg1vwmv 46 5 intestinal intestinal JJ cord-354827-ipg1vwmv 46 6 persistence persistence NN cord-354827-ipg1vwmv 46 7 ( ( -LRB- cord-354827-ipg1vwmv 46 8 e.g. e.g. RB cord-354827-ipg1vwmv 46 9 shdA shdA NNP cord-354827-ipg1vwmv 46 10 , , , cord-354827-ipg1vwmv 46 11 ratB ratb NN cord-354827-ipg1vwmv 46 12 ) ) -RRB- cord-354827-ipg1vwmv 46 13 or or CC cord-354827-ipg1vwmv 46 14 interaction interaction NN cord-354827-ipg1vwmv 46 15 with with IN cord-354827-ipg1vwmv 46 16 host host NN cord-354827-ipg1vwmv 46 17 surfaces surface NNS cord-354827-ipg1vwmv 46 18 ( ( -LRB- cord-354827-ipg1vwmv 46 19 e.g. e.g. RB cord-354827-ipg1vwmv 46 20 fimbria fimbria NNP cord-354827-ipg1vwmv 46 21 , , , cord-354827-ipg1vwmv 46 22 pili pili NNP cord-354827-ipg1vwmv 46 23 etc etc FW cord-354827-ipg1vwmv 46 24 . . . cord-354827-ipg1vwmv 46 25 ) ) -RRB- cord-354827-ipg1vwmv 46 26 are be VBP cord-354827-ipg1vwmv 46 27 inactivated inactivate VBN cord-354827-ipg1vwmv 46 28 , , , cord-354827-ipg1vwmv 46 29 limiting limit VBG cord-354827-ipg1vwmv 46 30 potential potential JJ cord-354827-ipg1vwmv 46 31 mechanisms mechanism NNS cord-354827-ipg1vwmv 46 32 for for IN cord-354827-ipg1vwmv 46 33 colonizing colonize VBG cord-354827-ipg1vwmv 46 34 within within IN cord-354827-ipg1vwmv 46 35 and and CC cord-354827-ipg1vwmv 46 36 between between IN cord-354827-ipg1vwmv 46 37 hosts host NNS cord-354827-ipg1vwmv 46 38 . . . cord-354827-ipg1vwmv 47 1 For for IN cord-354827-ipg1vwmv 47 2 example example NN cord-354827-ipg1vwmv 47 3 , , , cord-354827-ipg1vwmv 47 4 genes gene NNS cord-354827-ipg1vwmv 47 5 that that WDT cord-354827-ipg1vwmv 47 6 contribute contribute VBP cord-354827-ipg1vwmv 47 7 to to IN cord-354827-ipg1vwmv 47 8 fluid fluid JJ cord-354827-ipg1vwmv 47 9 release release NN cord-354827-ipg1vwmv 47 10 ( ( -LRB- cord-354827-ipg1vwmv 47 11 e.g. e.g. RB cord-354827-ipg1vwmv 47 12 sopA sopA VBN cord-354827-ipg1vwmv 47 13 ) ) -RRB- cord-354827-ipg1vwmv 47 14 or or CC cord-354827-ipg1vwmv 47 15 intracellular intracellular JJ cord-354827-ipg1vwmv 47 16 survival survival NN cord-354827-ipg1vwmv 47 17 ( ( -LRB- cord-354827-ipg1vwmv 47 18 e.g. e.g. NN cord-354827-ipg1vwmv 47 19 sopE2 sopE2 NNS cord-354827-ipg1vwmv 47 20 , , , cord-354827-ipg1vwmv 47 21 sseJ ssej JJ cord-354827-ipg1vwmv 47 22 , , , cord-354827-ipg1vwmv 47 23 ) ) -RRB- cord-354827-ipg1vwmv 47 24 are be VBP cord-354827-ipg1vwmv 47 25 inactivated inactivate VBN cord-354827-ipg1vwmv 47 26 [ [ -LRB- cord-354827-ipg1vwmv 47 27 13 13 CD cord-354827-ipg1vwmv 47 28 , , , cord-354827-ipg1vwmv 47 29 18 18 CD cord-354827-ipg1vwmv 47 30 ] ] -RRB- cord-354827-ipg1vwmv 47 31 . . . cord-354827-ipg1vwmv 48 1 Thus thus RB cord-354827-ipg1vwmv 48 2 , , , cord-354827-ipg1vwmv 48 3 invading invade VBG cord-354827-ipg1vwmv 48 4 S. S. NNP cord-354827-ipg1vwmv 48 5 Typhi Typhi NNP cord-354827-ipg1vwmv 48 6 may may MD cord-354827-ipg1vwmv 48 7 follow follow VB cord-354827-ipg1vwmv 48 8 a a DT cord-354827-ipg1vwmv 48 9 simple simple JJ cord-354827-ipg1vwmv 48 10 default default NN cord-354827-ipg1vwmv 48 11 pathway pathway NN cord-354827-ipg1vwmv 48 12 favoring favor VBG cord-354827-ipg1vwmv 48 13 limiting limit VBG cord-354827-ipg1vwmv 48 14 activation activation NN cord-354827-ipg1vwmv 48 15 of of IN cord-354827-ipg1vwmv 48 16 the the DT cord-354827-ipg1vwmv 48 17 inflammatory inflammatory JJ cord-354827-ipg1vwmv 48 18 response response NN cord-354827-ipg1vwmv 48 19 . . . cord-354827-ipg1vwmv 49 1 S. S. NNP cord-354827-ipg1vwmv 49 2 Typhi Typhi NNP cord-354827-ipg1vwmv 49 3 ( ( -LRB- cord-354827-ipg1vwmv 49 4 but but CC cord-354827-ipg1vwmv 49 5 not not RB cord-354827-ipg1vwmv 49 6 S. S. NNP cord-354827-ipg1vwmv 49 7 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 49 8 A A NNP cord-354827-ipg1vwmv 49 9 ) ) -RRB- cord-354827-ipg1vwmv 49 10 also also RB cord-354827-ipg1vwmv 49 11 expresses express VBZ cord-354827-ipg1vwmv 49 12 the the DT cord-354827-ipg1vwmv 49 13 Vi Vi NNP cord-354827-ipg1vwmv 49 14 capsular capsular NN cord-354827-ipg1vwmv 49 15 polysaccharide polysaccharide NN cord-354827-ipg1vwmv 49 16 , , , cord-354827-ipg1vwmv 49 17 that that WDT cord-354827-ipg1vwmv 49 18 possesses possess VBZ cord-354827-ipg1vwmv 49 19 immuno immuno JJ cord-354827-ipg1vwmv 49 20 - - JJ cord-354827-ipg1vwmv 49 21 modulatory modulatory JJ cord-354827-ipg1vwmv 49 22 properties property NNS cord-354827-ipg1vwmv 49 23 , , , cord-354827-ipg1vwmv 49 24 potentially potentially RB cord-354827-ipg1vwmv 49 25 further further RB cord-354827-ipg1vwmv 49 26 dampening dampen VBG cord-354827-ipg1vwmv 49 27 the the DT cord-354827-ipg1vwmv 49 28 immune immune JJ cord-354827-ipg1vwmv 49 29 response response NN cord-354827-ipg1vwmv 49 30 [ [ -LRB- cord-354827-ipg1vwmv 49 31 19 19 CD cord-354827-ipg1vwmv 49 32 , , , cord-354827-ipg1vwmv 49 33 20 20 CD cord-354827-ipg1vwmv 49 34 ] ] -RRB- cord-354827-ipg1vwmv 49 35 . . . cord-354827-ipg1vwmv 50 1 One one CD cord-354827-ipg1vwmv 50 2 of of IN cord-354827-ipg1vwmv 50 3 the the DT cord-354827-ipg1vwmv 50 4 consequences consequence NNS cord-354827-ipg1vwmv 50 5 of of IN cord-354827-ipg1vwmv 50 6 minimal minimal JJ cord-354827-ipg1vwmv 50 7 early early JJ cord-354827-ipg1vwmv 50 8 inflammation inflammation NN cord-354827-ipg1vwmv 50 9 is be VBZ cord-354827-ipg1vwmv 50 10 a a DT cord-354827-ipg1vwmv 50 11 lack lack NN cord-354827-ipg1vwmv 50 12 of of IN cord-354827-ipg1vwmv 50 13 the the DT cord-354827-ipg1vwmv 50 14 classical classical JJ cord-354827-ipg1vwmv 50 15 gastroenteritis gastroenteritis NN cord-354827-ipg1vwmv 50 16 associated associate VBN cord-354827-ipg1vwmv 50 17 with with IN cord-354827-ipg1vwmv 50 18 other other JJ cord-354827-ipg1vwmv 50 19 gastrointestinal gastrointestinal JJ cord-354827-ipg1vwmv 50 20 pathogens pathogen NNS cord-354827-ipg1vwmv 50 21 . . . cord-354827-ipg1vwmv 51 1 Additionally additionally RB cord-354827-ipg1vwmv 51 2 , , , cord-354827-ipg1vwmv 51 3 humans human NNS cord-354827-ipg1vwmv 51 4 do do VBP cord-354827-ipg1vwmv 51 5 not not RB cord-354827-ipg1vwmv 51 6 react react VB cord-354827-ipg1vwmv 51 7 clinically clinically RB cord-354827-ipg1vwmv 51 8 to to IN cord-354827-ipg1vwmv 51 9 the the DT cord-354827-ipg1vwmv 51 10 initial initial JJ cord-354827-ipg1vwmv 51 11 invasion invasion NN cord-354827-ipg1vwmv 51 12 step step NN cord-354827-ipg1vwmv 51 13 and and CC cord-354827-ipg1vwmv 51 14 there there EX cord-354827-ipg1vwmv 51 15 is be VBZ cord-354827-ipg1vwmv 51 16 an an DT cord-354827-ipg1vwmv 51 17 incubation incubation NN cord-354827-ipg1vwmv 51 18 period period NN cord-354827-ipg1vwmv 51 19 before before IN cord-354827-ipg1vwmv 51 20 disease disease NN cord-354827-ipg1vwmv 51 21 symptoms symptom NNS cord-354827-ipg1vwmv 51 22 emerge emerge VBP cord-354827-ipg1vwmv 51 23 , , , cord-354827-ipg1vwmv 51 24 which which WDT cord-354827-ipg1vwmv 51 25 occurs occur VBZ cord-354827-ipg1vwmv 51 26 during during IN cord-354827-ipg1vwmv 51 27 the the DT cord-354827-ipg1vwmv 51 28 systemic systemic JJ cord-354827-ipg1vwmv 51 29 phase phase NN cord-354827-ipg1vwmv 51 30 of of IN cord-354827-ipg1vwmv 51 31 infection infection NN cord-354827-ipg1vwmv 51 32 . . . cord-354827-ipg1vwmv 52 1 This this DT cord-354827-ipg1vwmv 52 2 stage stage NN cord-354827-ipg1vwmv 52 3 is be VBZ cord-354827-ipg1vwmv 52 4 one one CD cord-354827-ipg1vwmv 52 5 of of IN cord-354827-ipg1vwmv 52 6 the the DT cord-354827-ipg1vwmv 52 7 early early JJ cord-354827-ipg1vwmv 52 8 confounders confounder NNS cord-354827-ipg1vwmv 52 9 to to IN cord-354827-ipg1vwmv 52 10 typhoid typhoid NN cord-354827-ipg1vwmv 52 11 diagnostics diagnostic NNS cord-354827-ipg1vwmv 52 12 , , , cord-354827-ipg1vwmv 52 13 the the DT cord-354827-ipg1vwmv 52 14 temporal temporal JJ cord-354827-ipg1vwmv 52 15 distance distance NN cord-354827-ipg1vwmv 52 16 between between IN cord-354827-ipg1vwmv 52 17 infection infection NN cord-354827-ipg1vwmv 52 18 and and CC cord-354827-ipg1vwmv 52 19 disease disease NN cord-354827-ipg1vwmv 52 20 hinders hinder VBZ cord-354827-ipg1vwmv 52 21 the the DT cord-354827-ipg1vwmv 52 22 detection detection NN cord-354827-ipg1vwmv 52 23 of of IN cord-354827-ipg1vwmv 52 24 the the DT cord-354827-ipg1vwmv 52 25 organism organism NN cord-354827-ipg1vwmv 52 26 . . . cord-354827-ipg1vwmv 53 1 The the DT cord-354827-ipg1vwmv 53 2 presence presence NN cord-354827-ipg1vwmv 53 3 of of IN cord-354827-ipg1vwmv 53 4 bacteria bacteria NNS cord-354827-ipg1vwmv 53 5 in in IN cord-354827-ipg1vwmv 53 6 any any DT cord-354827-ipg1vwmv 53 7 tissue tissue NN cord-354827-ipg1vwmv 53 8 may may MD cord-354827-ipg1vwmv 53 9 be be VB cord-354827-ipg1vwmv 53 10 transient transient JJ cord-354827-ipg1vwmv 53 11 , , , cord-354827-ipg1vwmv 53 12 as as IN cord-354827-ipg1vwmv 53 13 cells cell NNS cord-354827-ipg1vwmv 53 14 traffic traffic NN cord-354827-ipg1vwmv 53 15 or or CC cord-354827-ipg1vwmv 53 16 become become VB cord-354827-ipg1vwmv 53 17 activated activate VBN cord-354827-ipg1vwmv 53 18 . . . cord-354827-ipg1vwmv 54 1 Thus thus RB cord-354827-ipg1vwmv 54 2 , , , cord-354827-ipg1vwmv 54 3 trafficking traffic VBG cord-354827-ipg1vwmv 54 4 in in IN cord-354827-ipg1vwmv 54 5 blood blood NN cord-354827-ipg1vwmv 54 6 may may MD cord-354827-ipg1vwmv 54 7 only only RB cord-354827-ipg1vwmv 54 8 occur occur VB cord-354827-ipg1vwmv 54 9 during during IN cord-354827-ipg1vwmv 54 10 a a DT cord-354827-ipg1vwmv 54 11 limited limited JJ cord-354827-ipg1vwmv 54 12 window window NN cord-354827-ipg1vwmv 54 13 , , , cord-354827-ipg1vwmv 54 14 making make VBG cord-354827-ipg1vwmv 54 15 a a DT cord-354827-ipg1vwmv 54 16 positive positive JJ cord-354827-ipg1vwmv 54 17 blood blood NN cord-354827-ipg1vwmv 54 18 culture culture NN cord-354827-ipg1vwmv 54 19 challenging challenge VBG cord-354827-ipg1vwmv 54 20 . . . cord-354827-ipg1vwmv 55 1 This this DT cord-354827-ipg1vwmv 55 2 situation situation NN cord-354827-ipg1vwmv 55 3 may may MD cord-354827-ipg1vwmv 55 4 be be VB cord-354827-ipg1vwmv 55 5 exacerbated exacerbate VBN cord-354827-ipg1vwmv 55 6 as as IN cord-354827-ipg1vwmv 55 7 many many JJ cord-354827-ipg1vwmv 55 8 patients patient NNS cord-354827-ipg1vwmv 55 9 reach reach VBP cord-354827-ipg1vwmv 55 10 microbiological microbiological JJ cord-354827-ipg1vwmv 55 11 facilities facility NNS cord-354827-ipg1vwmv 55 12 at at IN cord-354827-ipg1vwmv 55 13 a a DT cord-354827-ipg1vwmv 55 14 later later JJ cord-354827-ipg1vwmv 55 15 stage stage NN cord-354827-ipg1vwmv 55 16 of of IN cord-354827-ipg1vwmv 55 17 infection infection NN cord-354827-ipg1vwmv 55 18 or or CC cord-354827-ipg1vwmv 55 19 may may MD cord-354827-ipg1vwmv 55 20 be be VB cord-354827-ipg1vwmv 55 21 " " `` cord-354827-ipg1vwmv 55 22 self self NN cord-354827-ipg1vwmv 55 23 treated treat VBN cord-354827-ipg1vwmv 55 24 " " '' cord-354827-ipg1vwmv 55 25 with with IN cord-354827-ipg1vwmv 55 26 antimicrobials antimicrobial NNS cord-354827-ipg1vwmv 55 27 . . . cord-354827-ipg1vwmv 56 1 Thus thus RB cord-354827-ipg1vwmv 56 2 , , , cord-354827-ipg1vwmv 56 3 there there EX cord-354827-ipg1vwmv 56 4 are be VBP cord-354827-ipg1vwmv 56 5 a a DT cord-354827-ipg1vwmv 56 6 number number NN cord-354827-ipg1vwmv 56 7 of of IN cord-354827-ipg1vwmv 56 8 characteristics characteristic NNS cord-354827-ipg1vwmv 56 9 of of IN cord-354827-ipg1vwmv 56 10 the the DT cord-354827-ipg1vwmv 56 11 pathogenesis pathogenesis NN cord-354827-ipg1vwmv 56 12 of of IN cord-354827-ipg1vwmv 56 13 typhoid typhoid NN cord-354827-ipg1vwmv 56 14 that that WDT cord-354827-ipg1vwmv 56 15 impinge impinge VBP cord-354827-ipg1vwmv 56 16 on on IN cord-354827-ipg1vwmv 56 17 diagnostics diagnostic NNS cord-354827-ipg1vwmv 56 18 [ [ -LRB- cord-354827-ipg1vwmv 56 19 21 21 CD cord-354827-ipg1vwmv 56 20 , , , cord-354827-ipg1vwmv 56 21 22 22 CD cord-354827-ipg1vwmv 56 22 ] ] -RRB- cord-354827-ipg1vwmv 56 23 . . . cord-354827-ipg1vwmv 57 1 An an DT cord-354827-ipg1vwmv 57 2 obvious obvious JJ cord-354827-ipg1vwmv 57 3 caveat caveat NN cord-354827-ipg1vwmv 57 4 is be VBZ cord-354827-ipg1vwmv 57 5 the the DT cord-354827-ipg1vwmv 57 6 low low JJ cord-354827-ipg1vwmv 57 7 number number NN cord-354827-ipg1vwmv 57 8 of of IN cord-354827-ipg1vwmv 57 9 bacteria bacteria NNS cord-354827-ipg1vwmv 57 10 in in IN cord-354827-ipg1vwmv 57 11 the the DT cord-354827-ipg1vwmv 57 12 blood blood NN cord-354827-ipg1vwmv 57 13 and and CC cord-354827-ipg1vwmv 57 14 other other JJ cord-354827-ipg1vwmv 57 15 tissues tissue NNS cord-354827-ipg1vwmv 57 16 . . . cord-354827-ipg1vwmv 58 1 It -PRON- PRP cord-354827-ipg1vwmv 58 2 is be VBZ cord-354827-ipg1vwmv 58 3 theoretically theoretically RB cord-354827-ipg1vwmv 58 4 possible possible JJ cord-354827-ipg1vwmv 58 5 that that IN cord-354827-ipg1vwmv 58 6 there there EX cord-354827-ipg1vwmv 58 7 are be VBP cord-354827-ipg1vwmv 58 8 actually actually RB cord-354827-ipg1vwmv 58 9 high high JJ cord-354827-ipg1vwmv 58 10 levels level NNS cord-354827-ipg1vwmv 58 11 of of IN cord-354827-ipg1vwmv 58 12 organisms organism NNS cord-354827-ipg1vwmv 58 13 in in IN cord-354827-ipg1vwmv 58 14 the the DT cord-354827-ipg1vwmv 58 15 blood blood NN cord-354827-ipg1vwmv 58 16 but but CC cord-354827-ipg1vwmv 58 17 that that IN cord-354827-ipg1vwmv 58 18 these these DT cord-354827-ipg1vwmv 58 19 are be VBP cord-354827-ipg1vwmv 58 20 present present JJ cord-354827-ipg1vwmv 58 21 in in IN cord-354827-ipg1vwmv 58 22 an an DT cord-354827-ipg1vwmv 58 23 ' ' `` cord-354827-ipg1vwmv 58 24 unculturable unculturable JJ cord-354827-ipg1vwmv 58 25 ' ' '' cord-354827-ipg1vwmv 58 26 form form NN cord-354827-ipg1vwmv 58 27 . . . cord-354827-ipg1vwmv 59 1 For for IN cord-354827-ipg1vwmv 59 2 example example NN cord-354827-ipg1vwmv 59 3 , , , cord-354827-ipg1vwmv 59 4 the the DT cord-354827-ipg1vwmv 59 5 rapid rapid JJ cord-354827-ipg1vwmv 59 6 transfer transfer NN cord-354827-ipg1vwmv 59 7 of of IN cord-354827-ipg1vwmv 59 8 bacteria bacteria NNS cord-354827-ipg1vwmv 59 9 in in IN cord-354827-ipg1vwmv 59 10 a a DT cord-354827-ipg1vwmv 59 11 semi semi JJ cord-354827-ipg1vwmv 59 12 - - JJ cord-354827-ipg1vwmv 59 13 quiescent quiescent JJ cord-354827-ipg1vwmv 59 14 form form NN cord-354827-ipg1vwmv 59 15 from from IN cord-354827-ipg1vwmv 59 16 within within IN cord-354827-ipg1vwmv 59 17 an an DT cord-354827-ipg1vwmv 59 18 intracellular intracellular JJ cord-354827-ipg1vwmv 59 19 vacuole vacuole NN cord-354827-ipg1vwmv 59 20 to to IN cord-354827-ipg1vwmv 59 21 laboratory laboratory NN cord-354827-ipg1vwmv 59 22 media medium NNS cord-354827-ipg1vwmv 59 23 may may MD cord-354827-ipg1vwmv 59 24 kill kill VB cord-354827-ipg1vwmv 59 25 this this DT cord-354827-ipg1vwmv 59 26 fastidious fastidious JJ cord-354827-ipg1vwmv 59 27 and and CC cord-354827-ipg1vwmv 59 28 delicate delicate JJ cord-354827-ipg1vwmv 59 29 organism organism NN cord-354827-ipg1vwmv 59 30 . . . cord-354827-ipg1vwmv 60 1 S. S. NNP cord-354827-ipg1vwmv 60 2 Typhi Typhi NNP cord-354827-ipg1vwmv 60 3 is be VBZ cord-354827-ipg1vwmv 60 4 certainly certainly RB cord-354827-ipg1vwmv 60 5 less less RBR cord-354827-ipg1vwmv 60 6 robust robust JJ cord-354827-ipg1vwmv 60 7 than than IN cord-354827-ipg1vwmv 60 8 many many JJ cord-354827-ipg1vwmv 60 9 other other JJ cord-354827-ipg1vwmv 60 10 Salmonella Salmonella NNP cord-354827-ipg1vwmv 60 11 . . . cord-354827-ipg1vwmv 61 1 Bone bone NN cord-354827-ipg1vwmv 61 2 marrow marrow NN cord-354827-ipg1vwmv 61 3 is be VBZ cord-354827-ipg1vwmv 61 4 the the DT cord-354827-ipg1vwmv 61 5 most most RBS cord-354827-ipg1vwmv 61 6 sensitive sensitive JJ cord-354827-ipg1vwmv 61 7 culture culture NN cord-354827-ipg1vwmv 61 8 route route NN cord-354827-ipg1vwmv 61 9 but but CC cord-354827-ipg1vwmv 61 10 this this DT cord-354827-ipg1vwmv 61 11 is be VBZ cord-354827-ipg1vwmv 61 12 an an DT cord-354827-ipg1vwmv 61 13 invasive invasive JJ cord-354827-ipg1vwmv 61 14 procedure procedure NN cord-354827-ipg1vwmv 61 15 and and CC cord-354827-ipg1vwmv 61 16 is be VBZ cord-354827-ipg1vwmv 61 17 seldom seldom RB cord-354827-ipg1vwmv 61 18 performed perform VBN cord-354827-ipg1vwmv 61 19 outside outside JJ cord-354827-ipg1vwmv 61 20 specialist specialist NN cord-354827-ipg1vwmv 61 21 hospitals hospital NNS cord-354827-ipg1vwmv 61 22 . . . cord-354827-ipg1vwmv 62 1 Volunteers volunteer NNS cord-354827-ipg1vwmv 62 2 challenged challenge VBD cord-354827-ipg1vwmv 62 3 with with IN cord-354827-ipg1vwmv 62 4 virulent virulent JJ cord-354827-ipg1vwmv 62 5 and and CC cord-354827-ipg1vwmv 62 6 attenuated attenuated JJ cord-354827-ipg1vwmv 62 7 S. S. NNP cord-354827-ipg1vwmv 62 8 Typhi Typhi NNP cord-354827-ipg1vwmv 62 9 strains strain NNS cord-354827-ipg1vwmv 62 10 only only RB cord-354827-ipg1vwmv 62 11 shed shed VBD cord-354827-ipg1vwmv 62 12 the the DT cord-354827-ipg1vwmv 62 13 organism organism NN cord-354827-ipg1vwmv 62 14 sporadically sporadically RB cord-354827-ipg1vwmv 62 15 in in IN cord-354827-ipg1vwmv 62 16 stools stool NNS cord-354827-ipg1vwmv 62 17 , , , cord-354827-ipg1vwmv 62 18 potentially potentially RB cord-354827-ipg1vwmv 62 19 compromising compromise VBG cord-354827-ipg1vwmv 62 20 the the DT cord-354827-ipg1vwmv 62 21 stool stool NN cord-354827-ipg1vwmv 62 22 culturing culturing NN cord-354827-ipg1vwmv 62 23 approach approach NN cord-354827-ipg1vwmv 62 24 [ [ -LRB- cord-354827-ipg1vwmv 62 25 23 23 CD cord-354827-ipg1vwmv 62 26 , , , cord-354827-ipg1vwmv 62 27 24 24 CD cord-354827-ipg1vwmv 62 28 ] ] -RRB- cord-354827-ipg1vwmv 62 29 . . . cord-354827-ipg1vwmv 63 1 Many many JJ cord-354827-ipg1vwmv 63 2 systemic systemic JJ cord-354827-ipg1vwmv 63 3 pathogens pathogen NNS cord-354827-ipg1vwmv 63 4 exhibit exhibit VBP cord-354827-ipg1vwmv 63 5 the the DT cord-354827-ipg1vwmv 63 6 ability ability NN cord-354827-ipg1vwmv 63 7 to to TO cord-354827-ipg1vwmv 63 8 undergo undergo VB cord-354827-ipg1vwmv 63 9 antigenic antigenic JJ cord-354827-ipg1vwmv 63 10 variation variation NN cord-354827-ipg1vwmv 63 11 , , , cord-354827-ipg1vwmv 63 12 thus thus RB cord-354827-ipg1vwmv 63 13 allowing allow VBG cord-354827-ipg1vwmv 63 14 the the DT cord-354827-ipg1vwmv 63 15 organism organism NN cord-354827-ipg1vwmv 63 16 to to TO cord-354827-ipg1vwmv 63 17 divert divert VB cord-354827-ipg1vwmv 63 18 the the DT cord-354827-ipg1vwmv 63 19 immune immune JJ cord-354827-ipg1vwmv 63 20 response response NN cord-354827-ipg1vwmv 63 21 . . . cord-354827-ipg1vwmv 64 1 Analysis analysis NN cord-354827-ipg1vwmv 64 2 of of IN cord-354827-ipg1vwmv 64 3 multiple multiple JJ cord-354827-ipg1vwmv 64 4 S. S. NNP cord-354827-ipg1vwmv 64 5 Typhi Typhi NNP cord-354827-ipg1vwmv 64 6 genomes genome NNS cord-354827-ipg1vwmv 64 7 shows show VBZ cord-354827-ipg1vwmv 64 8 a a DT cord-354827-ipg1vwmv 64 9 lack lack NN cord-354827-ipg1vwmv 64 10 of of IN cord-354827-ipg1vwmv 64 11 obvious obvious JJ cord-354827-ipg1vwmv 64 12 evidence evidence NN cord-354827-ipg1vwmv 64 13 for for IN cord-354827-ipg1vwmv 64 14 any any DT cord-354827-ipg1vwmv 64 15 amount amount NN cord-354827-ipg1vwmv 64 16 of of IN cord-354827-ipg1vwmv 64 17 immune immune JJ cord-354827-ipg1vwmv 64 18 selection selection NN cord-354827-ipg1vwmv 64 19 on on IN cord-354827-ipg1vwmv 64 20 the the DT cord-354827-ipg1vwmv 64 21 organism organism NN cord-354827-ipg1vwmv 64 22 . . . cord-354827-ipg1vwmv 65 1 Furthermore furthermore RB cord-354827-ipg1vwmv 65 2 , , , cord-354827-ipg1vwmv 65 3 no no DT cord-354827-ipg1vwmv 65 4 known know VBN cord-354827-ipg1vwmv 65 5 S. S. NNP cord-354827-ipg1vwmv 65 6 Typhi Typhi NNP cord-354827-ipg1vwmv 65 7 antigens antigen NNS cord-354827-ipg1vwmv 65 8 exhibit exhibit VBP cord-354827-ipg1vwmv 65 9 significant significant JJ cord-354827-ipg1vwmv 65 10 evidence evidence NN cord-354827-ipg1vwmv 65 11 for for IN cord-354827-ipg1vwmv 65 12 variation variation NN cord-354827-ipg1vwmv 65 13 , , , cord-354827-ipg1vwmv 65 14 a a DT cord-354827-ipg1vwmv 65 15 fact fact NN cord-354827-ipg1vwmv 65 16 highlighted highlight VBN cord-354827-ipg1vwmv 65 17 by by IN cord-354827-ipg1vwmv 65 18 comparing compare VBG cord-354827-ipg1vwmv 65 19 gene gene NN cord-354827-ipg1vwmv 65 20 sequences sequence NNS cord-354827-ipg1vwmv 65 21 between between IN cord-354827-ipg1vwmv 65 22 phylogenetically phylogenetically RB cord-354827-ipg1vwmv 65 23 representative representative JJ cord-354827-ipg1vwmv 65 24 S. S. NNP cord-354827-ipg1vwmv 65 25 Typhi Typhi NNP cord-354827-ipg1vwmv 65 26 [ [ -LRB- cord-354827-ipg1vwmv 65 27 12 12 CD cord-354827-ipg1vwmv 65 28 ] ] -RRB- cord-354827-ipg1vwmv 65 29 . . . cord-354827-ipg1vwmv 66 1 These these DT cord-354827-ipg1vwmv 66 2 data datum NNS cord-354827-ipg1vwmv 66 3 provide provide VBP cord-354827-ipg1vwmv 66 4 further further JJ cord-354827-ipg1vwmv 66 5 evidence evidence NN cord-354827-ipg1vwmv 66 6 of of IN cord-354827-ipg1vwmv 66 7 the the DT cord-354827-ipg1vwmv 66 8 ability ability NN cord-354827-ipg1vwmv 66 9 of of IN cord-354827-ipg1vwmv 66 10 S. S. NNP cord-354827-ipg1vwmv 66 11 Typhi Typhi NNP cord-354827-ipg1vwmv 66 12 to to TO cord-354827-ipg1vwmv 66 13 cause cause VB cord-354827-ipg1vwmv 66 14 a a DT cord-354827-ipg1vwmv 66 15 systemic systemic JJ cord-354827-ipg1vwmv 66 16 infection infection NN cord-354827-ipg1vwmv 66 17 without without IN cord-354827-ipg1vwmv 66 18 stimulating stimulate VBG cord-354827-ipg1vwmv 66 19 a a DT cord-354827-ipg1vwmv 66 20 significant significant JJ cord-354827-ipg1vwmv 66 21 inflammatory inflammatory JJ cord-354827-ipg1vwmv 66 22 response response NN cord-354827-ipg1vwmv 66 23 and and CC cord-354827-ipg1vwmv 66 24 transfer transfer NN cord-354827-ipg1vwmv 66 25 from from IN cord-354827-ipg1vwmv 66 26 the the DT cord-354827-ipg1vwmv 66 27 gastrointestinal gastrointestinal JJ cord-354827-ipg1vwmv 66 28 lumen lumen NN cord-354827-ipg1vwmv 66 29 to to IN cord-354827-ipg1vwmv 66 30 the the DT cord-354827-ipg1vwmv 66 31 reticuloendothelial reticuloendothelial JJ cord-354827-ipg1vwmv 66 32 system system NN cord-354827-ipg1vwmv 66 33 in in IN cord-354827-ipg1vwmv 66 34 a a DT cord-354827-ipg1vwmv 66 35 relatively relatively RB cord-354827-ipg1vwmv 66 36 undetected undetected JJ cord-354827-ipg1vwmv 66 37 fashion fashion NN cord-354827-ipg1vwmv 66 38 . . . cord-354827-ipg1vwmv 67 1 Indeed indeed RB cord-354827-ipg1vwmv 67 2 , , , cord-354827-ipg1vwmv 67 3 one one PRP cord-354827-ipg1vwmv 67 4 may may MD cord-354827-ipg1vwmv 67 5 argue argue VB cord-354827-ipg1vwmv 67 6 that that IN cord-354827-ipg1vwmv 67 7 the the DT cord-354827-ipg1vwmv 67 8 ability ability NN cord-354827-ipg1vwmv 67 9 of of IN cord-354827-ipg1vwmv 67 10 S. S. NNP cord-354827-ipg1vwmv 67 11 Typhi Typhi NNP cord-354827-ipg1vwmv 67 12 to to TO cord-354827-ipg1vwmv 67 13 avoid avoid VB cord-354827-ipg1vwmv 67 14 immune immune JJ cord-354827-ipg1vwmv 67 15 detection detection NN cord-354827-ipg1vwmv 67 16 constitutes constitute VBZ cord-354827-ipg1vwmv 67 17 the the DT cord-354827-ipg1vwmv 67 18 organism organism NN cord-354827-ipg1vwmv 67 19 as as IN cord-354827-ipg1vwmv 67 20 a a DT cord-354827-ipg1vwmv 67 21 " " `` cord-354827-ipg1vwmv 67 22 stealth stealth JJ cord-354827-ipg1vwmv 67 23 " " '' cord-354827-ipg1vwmv 67 24 pathogen pathogen NN cord-354827-ipg1vwmv 67 25 and and CC cord-354827-ipg1vwmv 67 26 this this DT cord-354827-ipg1vwmv 67 27 has have VBZ cord-354827-ipg1vwmv 67 28 significant significant JJ cord-354827-ipg1vwmv 67 29 implications implication NNS cord-354827-ipg1vwmv 67 30 for for IN cord-354827-ipg1vwmv 67 31 diagnostics diagnostic NNS cord-354827-ipg1vwmv 67 32 . . . cord-354827-ipg1vwmv 68 1 The the DT cord-354827-ipg1vwmv 68 2 lack lack NN cord-354827-ipg1vwmv 68 3 of of IN cord-354827-ipg1vwmv 68 4 immune immune JJ cord-354827-ipg1vwmv 68 5 selection selection NN cord-354827-ipg1vwmv 68 6 on on IN cord-354827-ipg1vwmv 68 7 the the DT cord-354827-ipg1vwmv 68 8 organism organism NN cord-354827-ipg1vwmv 68 9 suggests suggest VBZ cord-354827-ipg1vwmv 68 10 that that IN cord-354827-ipg1vwmv 68 11 S. S. NNP cord-354827-ipg1vwmv 68 12 Typhi Typhi NNP cord-354827-ipg1vwmv 68 13 predominantly predominantly RB cord-354827-ipg1vwmv 68 14 occupies occupy VBZ cord-354827-ipg1vwmv 68 15 an an DT cord-354827-ipg1vwmv 68 16 privileged privileged JJ cord-354827-ipg1vwmv 68 17 niche niche NN cord-354827-ipg1vwmv 68 18 within within IN cord-354827-ipg1vwmv 68 19 the the DT cord-354827-ipg1vwmv 68 20 host host NN cord-354827-ipg1vwmv 68 21 , , , cord-354827-ipg1vwmv 68 22 a a DT cord-354827-ipg1vwmv 68 23 predominantly predominantly RB cord-354827-ipg1vwmv 68 24 intracellular intracellular JJ cord-354827-ipg1vwmv 68 25 pathogen pathogen NN cord-354827-ipg1vwmv 68 26 that that WDT cord-354827-ipg1vwmv 68 27 can can MD cord-354827-ipg1vwmv 68 28 survive survive VB cord-354827-ipg1vwmv 68 29 for for IN cord-354827-ipg1vwmv 68 30 long long JJ cord-354827-ipg1vwmv 68 31 periods period NNS cord-354827-ipg1vwmv 68 32 in in IN cord-354827-ipg1vwmv 68 33 this this DT cord-354827-ipg1vwmv 68 34 state state NN cord-354827-ipg1vwmv 68 35 . . . cord-354827-ipg1vwmv 69 1 Indeed indeed RB cord-354827-ipg1vwmv 69 2 , , , cord-354827-ipg1vwmv 69 3 frequent frequent JJ cord-354827-ipg1vwmv 69 4 relapses relapse NNS cord-354827-ipg1vwmv 69 5 associated associate VBN cord-354827-ipg1vwmv 69 6 with with IN cord-354827-ipg1vwmv 69 7 the the DT cord-354827-ipg1vwmv 69 8 recrudescence recrudescence NN cord-354827-ipg1vwmv 69 9 of of IN cord-354827-ipg1vwmv 69 10 the the DT cord-354827-ipg1vwmv 69 11 pathogen pathogen NN cord-354827-ipg1vwmv 69 12 and and CC cord-354827-ipg1vwmv 69 13 the the DT cord-354827-ipg1vwmv 69 14 lack lack NN cord-354827-ipg1vwmv 69 15 of of IN cord-354827-ipg1vwmv 69 16 immune immune JJ cord-354827-ipg1vwmv 69 17 protection protection NN cord-354827-ipg1vwmv 69 18 in in IN cord-354827-ipg1vwmv 69 19 typhoid typhoid NN cord-354827-ipg1vwmv 69 20 patients patient NNS cord-354827-ipg1vwmv 69 21 to to TO cord-354827-ipg1vwmv 69 22 re re VB cord-354827-ipg1vwmv 69 23 - - NN cord-354827-ipg1vwmv 69 24 infection infection NN cord-354827-ipg1vwmv 69 25 further further RB cord-354827-ipg1vwmv 69 26 supports support VBZ cord-354827-ipg1vwmv 69 27 a a DT cord-354827-ipg1vwmv 69 28 dampening dampening NN cord-354827-ipg1vwmv 69 29 of of IN cord-354827-ipg1vwmv 69 30 immunity immunity NN cord-354827-ipg1vwmv 69 31 [ [ -LRB- cord-354827-ipg1vwmv 69 32 25 25 CD cord-354827-ipg1vwmv 69 33 ] ] -RRB- cord-354827-ipg1vwmv 69 34 . . . cord-354827-ipg1vwmv 70 1 Thus thus RB cord-354827-ipg1vwmv 70 2 , , , cord-354827-ipg1vwmv 70 3 S. S. NNP cord-354827-ipg1vwmv 70 4 Typhi Typhi NNP cord-354827-ipg1vwmv 70 5 may may MD cord-354827-ipg1vwmv 70 6 induce induce VB cord-354827-ipg1vwmv 70 7 only only JJ cord-354827-ipg1vwmv 70 8 weak weak JJ cord-354827-ipg1vwmv 70 9 immunity immunity NN cord-354827-ipg1vwmv 70 10 , , , cord-354827-ipg1vwmv 70 11 including include VBG cord-354827-ipg1vwmv 70 12 a a DT cord-354827-ipg1vwmv 70 13 muted muted JJ cord-354827-ipg1vwmv 70 14 antibody antibody NN cord-354827-ipg1vwmv 70 15 response response NN cord-354827-ipg1vwmv 70 16 . . . cord-354827-ipg1vwmv 71 1 It -PRON- PRP cord-354827-ipg1vwmv 71 2 is be VBZ cord-354827-ipg1vwmv 71 3 worth worth JJ cord-354827-ipg1vwmv 71 4 noting note VBG cord-354827-ipg1vwmv 71 5 that that IN cord-354827-ipg1vwmv 71 6 in in IN cord-354827-ipg1vwmv 71 7 typhoid typhoid NN cord-354827-ipg1vwmv 71 8 endemic endemic JJ cord-354827-ipg1vwmv 71 9 areas area NNS cord-354827-ipg1vwmv 71 10 many many JJ cord-354827-ipg1vwmv 71 11 individuals individual NNS cord-354827-ipg1vwmv 71 12 who who WP cord-354827-ipg1vwmv 71 13 have have VBP cord-354827-ipg1vwmv 71 14 never never RB cord-354827-ipg1vwmv 71 15 reported report VBN cord-354827-ipg1vwmv 71 16 typhoid typhoid NN cord-354827-ipg1vwmv 71 17 exhibit exhibit NN cord-354827-ipg1vwmv 71 18 serological serological JJ cord-354827-ipg1vwmv 71 19 evidence evidence NN cord-354827-ipg1vwmv 71 20 that that IN cord-354827-ipg1vwmv 71 21 they -PRON- PRP cord-354827-ipg1vwmv 71 22 have have VBP cord-354827-ipg1vwmv 71 23 been be VBN cord-354827-ipg1vwmv 71 24 infected infect VBN cord-354827-ipg1vwmv 71 25 by by IN cord-354827-ipg1vwmv 71 26 the the DT cord-354827-ipg1vwmv 71 27 pathogen pathogen NN cord-354827-ipg1vwmv 71 28 [ [ -LRB- cord-354827-ipg1vwmv 71 29 26 26 CD cord-354827-ipg1vwmv 71 30 ] ] -RRB- cord-354827-ipg1vwmv 71 31 . . . cord-354827-ipg1vwmv 72 1 Thus thus RB cord-354827-ipg1vwmv 72 2 , , , cord-354827-ipg1vwmv 72 3 it -PRON- PRP cord-354827-ipg1vwmv 72 4 is be VBZ cord-354827-ipg1vwmv 72 5 highly highly RB cord-354827-ipg1vwmv 72 6 feasible feasible JJ cord-354827-ipg1vwmv 72 7 that that IN cord-354827-ipg1vwmv 72 8 many many JJ cord-354827-ipg1vwmv 72 9 people people NNS cord-354827-ipg1vwmv 72 10 who who WP cord-354827-ipg1vwmv 72 11 get get VBP cord-354827-ipg1vwmv 72 12 exposed expose VBN cord-354827-ipg1vwmv 72 13 by by IN cord-354827-ipg1vwmv 72 14 S. S. NNP cord-354827-ipg1vwmv 72 15 Typhi Typhi NNP cord-354827-ipg1vwmv 72 16 do do VBP cord-354827-ipg1vwmv 72 17 not not RB cord-354827-ipg1vwmv 72 18 progress progress VB cord-354827-ipg1vwmv 72 19 to to TO cord-354827-ipg1vwmv 72 20 develop develop VB cord-354827-ipg1vwmv 72 21 the the DT cord-354827-ipg1vwmv 72 22 recognized recognize VBN cord-354827-ipg1vwmv 72 23 disease disease NN cord-354827-ipg1vwmv 72 24 syndrome syndrome NN cord-354827-ipg1vwmv 72 25 , , , cord-354827-ipg1vwmv 72 26 or or CC cord-354827-ipg1vwmv 72 27 individuals individual NNS cord-354827-ipg1vwmv 72 28 have have VBP cord-354827-ipg1vwmv 72 29 a a DT cord-354827-ipg1vwmv 72 30 small small JJ cord-354827-ipg1vwmv 72 31 amount amount NN cord-354827-ipg1vwmv 72 32 of of IN cord-354827-ipg1vwmv 72 33 constant constant JJ cord-354827-ipg1vwmv 72 34 boosting boosting NN cord-354827-ipg1vwmv 72 35 due due IN cord-354827-ipg1vwmv 72 36 to to IN cord-354827-ipg1vwmv 72 37 prolonged prolong VBN cord-354827-ipg1vwmv 72 38 exposure exposure NN cord-354827-ipg1vwmv 72 39 . . . cord-354827-ipg1vwmv 73 1 An an DT cord-354827-ipg1vwmv 73 2 additional additional JJ cord-354827-ipg1vwmv 73 3 caveat caveat NN cord-354827-ipg1vwmv 73 4 for for IN cord-354827-ipg1vwmv 73 5 an an DT cord-354827-ipg1vwmv 73 6 effective effective JJ cord-354827-ipg1vwmv 73 7 and and CC cord-354827-ipg1vwmv 73 8 appropriate appropriate JJ cord-354827-ipg1vwmv 73 9 diagnostic diagnostic JJ cord-354827-ipg1vwmv 73 10 test test NN cord-354827-ipg1vwmv 73 11 is be VBZ cord-354827-ipg1vwmv 73 12 the the DT cord-354827-ipg1vwmv 73 13 cross cross NN cord-354827-ipg1vwmv 73 14 section section NN cord-354827-ipg1vwmv 73 15 of of IN cord-354827-ipg1vwmv 73 16 organisms organism NNS cord-354827-ipg1vwmv 73 17 that that WDT cord-354827-ipg1vwmv 73 18 can can MD cord-354827-ipg1vwmv 73 19 cause cause VB cord-354827-ipg1vwmv 73 20 a a DT cord-354827-ipg1vwmv 73 21 disease disease NN cord-354827-ipg1vwmv 73 22 syndrome syndrome NN cord-354827-ipg1vwmv 73 23 that that WDT cord-354827-ipg1vwmv 73 24 is be VBZ cord-354827-ipg1vwmv 73 25 , , , cord-354827-ipg1vwmv 73 26 clinically clinically RB cord-354827-ipg1vwmv 73 27 , , , cord-354827-ipg1vwmv 73 28 indistinguishable indistinguishable JJ cord-354827-ipg1vwmv 73 29 from from IN cord-354827-ipg1vwmv 73 30 typhoid typhoid NN cord-354827-ipg1vwmv 73 31 fever fever NN cord-354827-ipg1vwmv 73 32 . . . cord-354827-ipg1vwmv 74 1 Depending depend VBG cord-354827-ipg1vwmv 74 2 on on IN cord-354827-ipg1vwmv 74 3 the the DT cord-354827-ipg1vwmv 74 4 location location NN cord-354827-ipg1vwmv 74 5 , , , cord-354827-ipg1vwmv 74 6 a a DT cord-354827-ipg1vwmv 74 7 number number NN cord-354827-ipg1vwmv 74 8 of of IN cord-354827-ipg1vwmv 74 9 viral viral JJ cord-354827-ipg1vwmv 74 10 , , , cord-354827-ipg1vwmv 74 11 parasitic parasitic JJ cord-354827-ipg1vwmv 74 12 and and CC cord-354827-ipg1vwmv 74 13 bacterial bacterial JJ cord-354827-ipg1vwmv 74 14 pathogens pathogen NNS cord-354827-ipg1vwmv 74 15 can can MD cord-354827-ipg1vwmv 74 16 mimic mimic VB cord-354827-ipg1vwmv 74 17 the the DT cord-354827-ipg1vwmv 74 18 basic basic JJ cord-354827-ipg1vwmv 74 19 features feature NNS cord-354827-ipg1vwmv 74 20 of of IN cord-354827-ipg1vwmv 74 21 typhoid typhoid NN cord-354827-ipg1vwmv 74 22 thus thus RB cord-354827-ipg1vwmv 74 23 confounding confound VBG cord-354827-ipg1vwmv 74 24 the the DT cord-354827-ipg1vwmv 74 25 issues issue NNS cord-354827-ipg1vwmv 74 26 of of IN cord-354827-ipg1vwmv 74 27 sample sample NN cord-354827-ipg1vwmv 74 28 collection collection NN cord-354827-ipg1vwmv 74 29 , , , cord-354827-ipg1vwmv 74 30 clinical clinical JJ cord-354827-ipg1vwmv 74 31 management management NN cord-354827-ipg1vwmv 74 32 and and CC cord-354827-ipg1vwmv 74 33 efficient efficient JJ cord-354827-ipg1vwmv 74 34 diagnosis diagnosis NN cord-354827-ipg1vwmv 74 35 . . . cord-354827-ipg1vwmv 75 1 The the DT cord-354827-ipg1vwmv 75 2 limitations limitation NNS cord-354827-ipg1vwmv 75 3 of of IN cord-354827-ipg1vwmv 75 4 microbiological microbiological JJ cord-354827-ipg1vwmv 75 5 culture culture NN cord-354827-ipg1vwmv 75 6 S. S. NNP cord-354827-ipg1vwmv 75 7 Typhi Typhi NNP cord-354827-ipg1vwmv 75 8 are be VBP cord-354827-ipg1vwmv 75 9 ordinarily ordinarily RB cord-354827-ipg1vwmv 75 10 cultured culture VBN cord-354827-ipg1vwmv 75 11 from from IN cord-354827-ipg1vwmv 75 12 5 5 CD cord-354827-ipg1vwmv 75 13 - - SYM cord-354827-ipg1vwmv 75 14 10 10 CD cord-354827-ipg1vwmv 75 15 ml ml NNS cord-354827-ipg1vwmv 75 16 of of IN cord-354827-ipg1vwmv 75 17 blood blood NN cord-354827-ipg1vwmv 75 18 in in IN cord-354827-ipg1vwmv 75 19 30 30 CD cord-354827-ipg1vwmv 75 20 - - SYM cord-354827-ipg1vwmv 75 21 50 50 CD cord-354827-ipg1vwmv 75 22 ml ml NNS cord-354827-ipg1vwmv 75 23 of of IN cord-354827-ipg1vwmv 75 24 broth broth NN cord-354827-ipg1vwmv 75 25 . . . cord-354827-ipg1vwmv 76 1 The the DT cord-354827-ipg1vwmv 76 2 probability probability NN cord-354827-ipg1vwmv 76 3 of of IN cord-354827-ipg1vwmv 76 4 recovering recover VBG cord-354827-ipg1vwmv 76 5 Typhi Typhi NNP cord-354827-ipg1vwmv 76 6 is be VBZ cord-354827-ipg1vwmv 76 7 transferred transfer VBN cord-354827-ipg1vwmv 76 8 to to IN cord-354827-ipg1vwmv 76 9 monocytic monocytic JJ cord-354827-ipg1vwmv 76 10 cells cell NNS cord-354827-ipg1vwmv 76 11 and and CC cord-354827-ipg1vwmv 76 12 is be VBZ cord-354827-ipg1vwmv 76 13 trafficked traffic VBN cord-354827-ipg1vwmv 76 14 to to IN cord-354827-ipg1vwmv 76 15 the the DT cord-354827-ipg1vwmv 76 16 reticulo reticulo NN cord-354827-ipg1vwmv 76 17 - - HYPH cord-354827-ipg1vwmv 76 18 endothelial endothelial JJ cord-354827-ipg1vwmv 76 19 system system NN cord-354827-ipg1vwmv 76 20 , , , cord-354827-ipg1vwmv 76 21 potentially potentially RB cord-354827-ipg1vwmv 76 22 in in IN cord-354827-ipg1vwmv 76 23 a a DT cord-354827-ipg1vwmv 76 24 semidormant semidormant JJ cord-354827-ipg1vwmv 76 25 state state NN cord-354827-ipg1vwmv 76 26 . . . cord-354827-ipg1vwmv 77 1 E e LS cord-354827-ipg1vwmv 77 2 ; ; : cord-354827-ipg1vwmv 78 1 S. S. NNP cord-354827-ipg1vwmv 78 2 Typhi Typhi NNP cord-354827-ipg1vwmv 78 3 re re NN cord-354827-ipg1vwmv 78 4 - - VBZ cord-354827-ipg1vwmv 78 5 emerges emerge VBZ cord-354827-ipg1vwmv 78 6 at at IN cord-354827-ipg1vwmv 78 7 an an DT cord-354827-ipg1vwmv 78 8 unknown unknown JJ cord-354827-ipg1vwmv 78 9 time time NN cord-354827-ipg1vwmv 78 10 from from IN cord-354827-ipg1vwmv 78 11 the the DT cord-354827-ipg1vwmv 78 12 reticulo reticulo NN cord-354827-ipg1vwmv 78 13 - - HYPH cord-354827-ipg1vwmv 78 14 endothelial endothelial JJ cord-354827-ipg1vwmv 78 15 system system NN cord-354827-ipg1vwmv 78 16 , , , cord-354827-ipg1vwmv 78 17 possibly possibly RB cord-354827-ipg1vwmv 78 18 as as IN cord-354827-ipg1vwmv 78 19 the the DT cord-354827-ipg1vwmv 78 20 acquired acquire VBN cord-354827-ipg1vwmv 78 21 immune immune JJ cord-354827-ipg1vwmv 78 22 response response NN cord-354827-ipg1vwmv 78 23 is be VBZ cord-354827-ipg1vwmv 78 24 activated activate VBN cord-354827-ipg1vwmv 78 25 , , , cord-354827-ipg1vwmv 78 26 and and CC cord-354827-ipg1vwmv 78 27 re re NN cord-354827-ipg1vwmv 78 28 - - NN cord-354827-ipg1vwmv 78 29 enters enter VBZ cord-354827-ipg1vwmv 78 30 the the DT cord-354827-ipg1vwmv 78 31 blood blood NN cord-354827-ipg1vwmv 78 32 stream stream NN cord-354827-ipg1vwmv 78 33 in in IN cord-354827-ipg1vwmv 78 34 low low JJ cord-354827-ipg1vwmv 78 35 numbers number NNS cord-354827-ipg1vwmv 78 36 . . . cord-354827-ipg1vwmv 79 1 F F NNP cord-354827-ipg1vwmv 79 2 ; ; : cord-354827-ipg1vwmv 79 3 S. S. NNP cord-354827-ipg1vwmv 79 4 Typhi Typhi NNP cord-354827-ipg1vwmv 79 5 seeds seed NNS cord-354827-ipg1vwmv 79 6 into into IN cord-354827-ipg1vwmv 79 7 the the DT cord-354827-ipg1vwmv 79 8 liver liver NN cord-354827-ipg1vwmv 79 9 , , , cord-354827-ipg1vwmv 79 10 the the DT cord-354827-ipg1vwmv 79 11 gall gall NN cord-354827-ipg1vwmv 79 12 bladder bladder NN cord-354827-ipg1vwmv 79 13 and and CC cord-354827-ipg1vwmv 79 14 the the DT cord-354827-ipg1vwmv 79 15 bone bone NN cord-354827-ipg1vwmv 79 16 marrow marrow NN cord-354827-ipg1vwmv 79 17 where where WRB cord-354827-ipg1vwmv 79 18 it -PRON- PRP cord-354827-ipg1vwmv 79 19 can can MD cord-354827-ipg1vwmv 79 20 reside reside VB cord-354827-ipg1vwmv 79 21 and and CC cord-354827-ipg1vwmv 79 22 may may MD cord-354827-ipg1vwmv 79 23 be be VB cord-354827-ipg1vwmv 79 24 detected detect VBN cord-354827-ipg1vwmv 79 25 for for IN cord-354827-ipg1vwmv 79 26 months month NNS cord-354827-ipg1vwmv 79 27 or or CC cord-354827-ipg1vwmv 79 28 years year NNS cord-354827-ipg1vwmv 79 29 . . . cord-354827-ipg1vwmv 80 1 G G NNP cord-354827-ipg1vwmv 80 2 ; ; : cord-354827-ipg1vwmv 80 3 S. S. NNP cord-354827-ipg1vwmv 80 4 Typhi Typhi NNP cord-354827-ipg1vwmv 80 5 can can MD cord-354827-ipg1vwmv 80 6 enter enter VB cord-354827-ipg1vwmv 80 7 into into IN cord-354827-ipg1vwmv 80 8 the the DT cord-354827-ipg1vwmv 80 9 bile bile NN cord-354827-ipg1vwmv 80 10 duct duct NN cord-354827-ipg1vwmv 80 11 and and CC cord-354827-ipg1vwmv 80 12 be be VB cord-354827-ipg1vwmv 80 13 shed shed VBN cord-354827-ipg1vwmv 80 14 sporadically sporadically RB cord-354827-ipg1vwmv 80 15 , , , cord-354827-ipg1vwmv 80 16 potentially potentially RB cord-354827-ipg1vwmv 80 17 in in IN cord-354827-ipg1vwmv 80 18 high high JJ cord-354827-ipg1vwmv 80 19 numbers number NNS cord-354827-ipg1vwmv 80 20 into into IN cord-354827-ipg1vwmv 80 21 the the DT cord-354827-ipg1vwmv 80 22 environment environment NN cord-354827-ipg1vwmv 80 23 via via IN cord-354827-ipg1vwmv 80 24 the the DT cord-354827-ipg1vwmv 80 25 intestine intestine NN cord-354827-ipg1vwmv 80 26 . . . cord-354827-ipg1vwmv 81 1 organisms organism NNS cord-354827-ipg1vwmv 81 2 is be VBZ cord-354827-ipg1vwmv 81 3 increased increase VBN cord-354827-ipg1vwmv 81 4 at at IN cord-354827-ipg1vwmv 81 5 greater great JJR cord-354827-ipg1vwmv 81 6 blood blood NN cord-354827-ipg1vwmv 81 7 volumes volume NNS cord-354827-ipg1vwmv 81 8 , , , cord-354827-ipg1vwmv 81 9 compromising compromise VBG cord-354827-ipg1vwmv 81 10 diagnosis diagnosis NN cord-354827-ipg1vwmv 81 11 in in IN cord-354827-ipg1vwmv 81 12 children child NNS cord-354827-ipg1vwmv 81 13 . . . cord-354827-ipg1vwmv 82 1 In in IN cord-354827-ipg1vwmv 82 2 the the DT cord-354827-ipg1vwmv 82 3 developed develop VBN cord-354827-ipg1vwmv 82 4 world world NN cord-354827-ipg1vwmv 82 5 , , , cord-354827-ipg1vwmv 82 6 blood blood NN cord-354827-ipg1vwmv 82 7 culture culture NN cord-354827-ipg1vwmv 82 8 is be VBZ cord-354827-ipg1vwmv 82 9 semi semi RB cord-354827-ipg1vwmv 82 10 - - JJ cord-354827-ipg1vwmv 82 11 automated automated JJ cord-354827-ipg1vwmv 82 12 , , , cord-354827-ipg1vwmv 82 13 exploiting exploit VBG cord-354827-ipg1vwmv 82 14 sophisticated sophisticated JJ cord-354827-ipg1vwmv 82 15 culture culture NN cord-354827-ipg1vwmv 82 16 apparatus apparatus NN cord-354827-ipg1vwmv 82 17 . . . cord-354827-ipg1vwmv 83 1 Blood blood NN cord-354827-ipg1vwmv 83 2 taken take VBN cord-354827-ipg1vwmv 83 3 from from IN cord-354827-ipg1vwmv 83 4 patients patient NNS cord-354827-ipg1vwmv 83 5 is be VBZ cord-354827-ipg1vwmv 83 6 inoculated inoculate VBN cord-354827-ipg1vwmv 83 7 into into IN cord-354827-ipg1vwmv 83 8 vessels vessel NNS cord-354827-ipg1vwmv 83 9 which which WDT cord-354827-ipg1vwmv 83 10 are be VBP cord-354827-ipg1vwmv 83 11 designed design VBN cord-354827-ipg1vwmv 83 12 to to TO cord-354827-ipg1vwmv 83 13 fit fit VB cord-354827-ipg1vwmv 83 14 in in IN cord-354827-ipg1vwmv 83 15 specific specific JJ cord-354827-ipg1vwmv 83 16 machines machine NNS cord-354827-ipg1vwmv 83 17 and and CC cord-354827-ipg1vwmv 83 18 contain contain VB cord-354827-ipg1vwmv 83 19 specialized specialized JJ cord-354827-ipg1vwmv 83 20 media medium NNS cord-354827-ipg1vwmv 83 21 , , , cord-354827-ipg1vwmv 83 22 often often RB cord-354827-ipg1vwmv 83 23 there there EX cord-354827-ipg1vwmv 83 24 is be VBZ cord-354827-ipg1vwmv 83 25 minimal minimal JJ cord-354827-ipg1vwmv 83 26 or or CC cord-354827-ipg1vwmv 83 27 no no DT cord-354827-ipg1vwmv 83 28 dilution dilution NN cord-354827-ipg1vwmv 83 29 of of IN cord-354827-ipg1vwmv 83 30 the the DT cord-354827-ipg1vwmv 83 31 sample sample NN cord-354827-ipg1vwmv 83 32 into into IN cord-354827-ipg1vwmv 83 33 this this DT cord-354827-ipg1vwmv 83 34 media medium NNS cord-354827-ipg1vwmv 83 35 . . . cord-354827-ipg1vwmv 84 1 In in IN cord-354827-ipg1vwmv 84 2 this this DT cord-354827-ipg1vwmv 84 3 way way NN cord-354827-ipg1vwmv 84 4 , , , cord-354827-ipg1vwmv 84 5 the the DT cord-354827-ipg1vwmv 84 6 whole whole JJ cord-354827-ipg1vwmv 84 7 process process NN cord-354827-ipg1vwmv 84 8 can can MD cord-354827-ipg1vwmv 84 9 be be VB cord-354827-ipg1vwmv 84 10 captured capture VBN cord-354827-ipg1vwmv 84 11 by by IN cord-354827-ipg1vwmv 84 12 an an DT cord-354827-ipg1vwmv 84 13 integrated integrated JJ cord-354827-ipg1vwmv 84 14 system system NN cord-354827-ipg1vwmv 84 15 and and CC cord-354827-ipg1vwmv 84 16 a a DT cord-354827-ipg1vwmv 84 17 particular particular JJ cord-354827-ipg1vwmv 84 18 laboratory laboratory NN cord-354827-ipg1vwmv 84 19 may may MD cord-354827-ipg1vwmv 84 20 become become VB cord-354827-ipg1vwmv 84 21 dependent dependent JJ cord-354827-ipg1vwmv 84 22 on on IN cord-354827-ipg1vwmv 84 23 the the DT cord-354827-ipg1vwmv 84 24 same same JJ cord-354827-ipg1vwmv 84 25 supplier supplier NN cord-354827-ipg1vwmv 84 26 , , , cord-354827-ipg1vwmv 84 27 which which WDT cord-354827-ipg1vwmv 84 28 has have VBZ cord-354827-ipg1vwmv 84 29 particular particular JJ cord-354827-ipg1vwmv 84 30 financial financial JJ cord-354827-ipg1vwmv 84 31 constraints constraint NNS cord-354827-ipg1vwmv 84 32 . . . cord-354827-ipg1vwmv 85 1 The the DT cord-354827-ipg1vwmv 85 2 advantage advantage NN cord-354827-ipg1vwmv 85 3 of of IN cord-354827-ipg1vwmv 85 4 this this DT cord-354827-ipg1vwmv 85 5 approach approach NN cord-354827-ipg1vwmv 85 6 is be VBZ cord-354827-ipg1vwmv 85 7 that that IN cord-354827-ipg1vwmv 85 8 it -PRON- PRP cord-354827-ipg1vwmv 85 9 improves improve VBZ cord-354827-ipg1vwmv 85 10 specificity specificity NN cord-354827-ipg1vwmv 85 11 and and CC cord-354827-ipg1vwmv 85 12 standardization standardization NN cord-354827-ipg1vwmv 85 13 . . . cord-354827-ipg1vwmv 86 1 The the DT cord-354827-ipg1vwmv 86 2 main main JJ cord-354827-ipg1vwmv 86 3 limitation limitation NN cord-354827-ipg1vwmv 86 4 to to IN cord-354827-ipg1vwmv 86 5 the the DT cord-354827-ipg1vwmv 86 6 wide wide JJ cord-354827-ipg1vwmv 86 7 spread spread NN cord-354827-ipg1vwmv 86 8 distribution distribution NN cord-354827-ipg1vwmv 86 9 of of IN cord-354827-ipg1vwmv 86 10 semi semi JJ cord-354827-ipg1vwmv 86 11 - - JJ cord-354827-ipg1vwmv 86 12 automated automated JJ cord-354827-ipg1vwmv 86 13 blood blood NN cord-354827-ipg1vwmv 86 14 culture culture NN cord-354827-ipg1vwmv 86 15 systems system NNS cord-354827-ipg1vwmv 86 16 is be VBZ cord-354827-ipg1vwmv 86 17 cost cost VBN cord-354827-ipg1vwmv 86 18 . . . cord-354827-ipg1vwmv 87 1 Blood blood NN cord-354827-ipg1vwmv 87 2 culture culture NN cord-354827-ipg1vwmv 87 3 facilities facility NNS cord-354827-ipg1vwmv 87 4 are be VBP cord-354827-ipg1vwmv 87 5 rare rare JJ cord-354827-ipg1vwmv 87 6 in in IN cord-354827-ipg1vwmv 87 7 many many JJ cord-354827-ipg1vwmv 87 8 developing develop VBG cord-354827-ipg1vwmv 87 9 countries country NNS cord-354827-ipg1vwmv 87 10 , , , cord-354827-ipg1vwmv 87 11 often often RB cord-354827-ipg1vwmv 87 12 limited limit VBN cord-354827-ipg1vwmv 87 13 only only RB cord-354827-ipg1vwmv 87 14 to to IN cord-354827-ipg1vwmv 87 15 major major JJ cord-354827-ipg1vwmv 87 16 hospitals hospital NNS cord-354827-ipg1vwmv 87 17 in in IN cord-354827-ipg1vwmv 87 18 large large JJ cord-354827-ipg1vwmv 87 19 cities city NNS cord-354827-ipg1vwmv 87 20 . . . cord-354827-ipg1vwmv 88 1 Access access NN cord-354827-ipg1vwmv 88 2 to to IN cord-354827-ipg1vwmv 88 3 receiving receive VBG cord-354827-ipg1vwmv 88 4 a a DT cord-354827-ipg1vwmv 88 5 blood blood NN cord-354827-ipg1vwmv 88 6 culture culture NN cord-354827-ipg1vwmv 88 7 becomes become VBZ cord-354827-ipg1vwmv 88 8 , , , cord-354827-ipg1vwmv 88 9 therefore therefore RB cord-354827-ipg1vwmv 88 10 , , , cord-354827-ipg1vwmv 88 11 the the DT cord-354827-ipg1vwmv 88 12 limiting limit VBG cord-354827-ipg1vwmv 88 13 factor factor NN cord-354827-ipg1vwmv 88 14 to to IN cord-354827-ipg1vwmv 88 15 typhoid typhoid NN cord-354827-ipg1vwmv 88 16 diagnosis diagnosis NN cord-354827-ipg1vwmv 88 17 . . . cord-354827-ipg1vwmv 89 1 It -PRON- PRP cord-354827-ipg1vwmv 89 2 is be VBZ cord-354827-ipg1vwmv 89 3 worth worth JJ cord-354827-ipg1vwmv 89 4 speculating speculate VBG cord-354827-ipg1vwmv 89 5 that that IN cord-354827-ipg1vwmv 89 6 alternative alternative JJ cord-354827-ipg1vwmv 89 7 culture culture NN cord-354827-ipg1vwmv 89 8 systems system NNS cord-354827-ipg1vwmv 89 9 , , , cord-354827-ipg1vwmv 89 10 made make VBN cord-354827-ipg1vwmv 89 11 available available JJ cord-354827-ipg1vwmv 89 12 at at IN cord-354827-ipg1vwmv 89 13 a a DT cord-354827-ipg1vwmv 89 14 lower low JJR cord-354827-ipg1vwmv 89 15 cost cost NN cord-354827-ipg1vwmv 89 16 and and CC cord-354827-ipg1vwmv 89 17 less less RBR cord-354827-ipg1vwmv 89 18 dependent dependent JJ cord-354827-ipg1vwmv 89 19 on on IN cord-354827-ipg1vwmv 89 20 expensive expensive JJ cord-354827-ipg1vwmv 89 21 consumables consumable NNS cord-354827-ipg1vwmv 89 22 , , , cord-354827-ipg1vwmv 89 23 could could MD cord-354827-ipg1vwmv 89 24 encourage encourage VB cord-354827-ipg1vwmv 89 25 more more JJR cord-354827-ipg1vwmv 89 26 facilities facility NNS cord-354827-ipg1vwmv 89 27 to to TO cord-354827-ipg1vwmv 89 28 be be VB cord-354827-ipg1vwmv 89 29 established establish VBN cord-354827-ipg1vwmv 89 30 in in IN cord-354827-ipg1vwmv 89 31 poorer poor JJR cord-354827-ipg1vwmv 89 32 regions region NNS cord-354827-ipg1vwmv 89 33 . . . cord-354827-ipg1vwmv 90 1 It -PRON- PRP cord-354827-ipg1vwmv 90 2 is be VBZ cord-354827-ipg1vwmv 90 3 also also RB cord-354827-ipg1vwmv 90 4 worth worth JJ cord-354827-ipg1vwmv 90 5 noting note VBG cord-354827-ipg1vwmv 90 6 that that IN cord-354827-ipg1vwmv 90 7 in in IN cord-354827-ipg1vwmv 90 8 a a DT cord-354827-ipg1vwmv 90 9 single single JJ cord-354827-ipg1vwmv 90 10 tropical tropical JJ cord-354827-ipg1vwmv 90 11 setting set VBG cord-354827-ipg1vwmv 90 12 blood blood NN cord-354827-ipg1vwmv 90 13 infections infection NNS cord-354827-ipg1vwmv 90 14 may may MD cord-354827-ipg1vwmv 90 15 be be VB cord-354827-ipg1vwmv 90 16 caused cause VBN cord-354827-ipg1vwmv 90 17 by by IN cord-354827-ipg1vwmv 90 18 a a DT cord-354827-ipg1vwmv 90 19 wide wide JJ cord-354827-ipg1vwmv 90 20 range range NN cord-354827-ipg1vwmv 90 21 of of IN cord-354827-ipg1vwmv 90 22 other other JJ cord-354827-ipg1vwmv 90 23 gram gram NN cord-354827-ipg1vwmv 90 24 negative negative JJ cord-354827-ipg1vwmv 90 25 and and CC cord-354827-ipg1vwmv 90 26 gram gram JJ cord-354827-ipg1vwmv 90 27 positive positive JJ cord-354827-ipg1vwmv 90 28 organisms organism NNS cord-354827-ipg1vwmv 90 29 ( ( -LRB- cord-354827-ipg1vwmv 91 1 e.g. e.g. RB cord-354827-ipg1vwmv 91 2 S. S. NNP cord-354827-ipg1vwmv 91 3 Typhi Typhi NNP cord-354827-ipg1vwmv 91 4 , , , cord-354827-ipg1vwmv 91 5 Streptococci Streptococci NNP cord-354827-ipg1vwmv 91 6 , , , cord-354827-ipg1vwmv 91 7 Leptospira Leptospira NNP cord-354827-ipg1vwmv 91 8 , , , cord-354827-ipg1vwmv 91 9 etc etc FW cord-354827-ipg1vwmv 91 10 . . . cord-354827-ipg1vwmv 91 11 ) ) -RRB- cord-354827-ipg1vwmv 91 12 , , , cord-354827-ipg1vwmv 91 13 parasites parasite NNS cord-354827-ipg1vwmv 91 14 ( ( -LRB- cord-354827-ipg1vwmv 91 15 e.g. e.g. RB cord-354827-ipg1vwmv 91 16 Plasmodium Plasmodium NNP cord-354827-ipg1vwmv 91 17 ) ) -RRB- cord-354827-ipg1vwmv 91 18 and and CC cord-354827-ipg1vwmv 91 19 viruses virus NNS cord-354827-ipg1vwmv 91 20 ( ( -LRB- cord-354827-ipg1vwmv 91 21 e.g. e.g. IN cord-354827-ipg1vwmv 91 22 dengue dengue NN cord-354827-ipg1vwmv 91 23 ) ) -RRB- cord-354827-ipg1vwmv 91 24 [ [ -LRB- cord-354827-ipg1vwmv 91 25 27 27 CD cord-354827-ipg1vwmv 91 26 , , , cord-354827-ipg1vwmv 91 27 28 28 CD cord-354827-ipg1vwmv 91 28 ] ] -RRB- cord-354827-ipg1vwmv 91 29 . . . cord-354827-ipg1vwmv 92 1 Blood blood NN cord-354827-ipg1vwmv 92 2 culture culture NN cord-354827-ipg1vwmv 92 3 may may MD cord-354827-ipg1vwmv 92 4 or or CC cord-354827-ipg1vwmv 92 5 may may MD cord-354827-ipg1vwmv 92 6 not not RB cord-354827-ipg1vwmv 92 7 be be VB cord-354827-ipg1vwmv 92 8 a a DT cord-354827-ipg1vwmv 92 9 suitable suitable JJ cord-354827-ipg1vwmv 92 10 assay assay NN cord-354827-ipg1vwmv 92 11 for for IN cord-354827-ipg1vwmv 92 12 a a DT cord-354827-ipg1vwmv 92 13 specific specific JJ cord-354827-ipg1vwmv 92 14 infection infection NN cord-354827-ipg1vwmv 92 15 , , , cord-354827-ipg1vwmv 92 16 depending depend VBG cord-354827-ipg1vwmv 92 17 on on IN cord-354827-ipg1vwmv 92 18 the the DT cord-354827-ipg1vwmv 92 19 pathogen pathogen NN cord-354827-ipg1vwmv 92 20 and and CC cord-354827-ipg1vwmv 92 21 the the DT cord-354827-ipg1vwmv 92 22 location location NN cord-354827-ipg1vwmv 92 23 . . . cord-354827-ipg1vwmv 93 1 Taken take VBN cord-354827-ipg1vwmv 93 2 that that IN cord-354827-ipg1vwmv 93 3 there there EX cord-354827-ipg1vwmv 93 4 are be VBP cord-354827-ipg1vwmv 93 5 only only RB cord-354827-ipg1vwmv 93 6 low low JJ cord-354827-ipg1vwmv 93 7 levels level NNS cord-354827-ipg1vwmv 93 8 of of IN cord-354827-ipg1vwmv 93 9 S. S. NNP cord-354827-ipg1vwmv 93 10 Typhi Typhi NNP cord-354827-ipg1vwmv 93 11 present present NN cord-354827-ipg1vwmv 93 12 in in IN cord-354827-ipg1vwmv 93 13 blood blood NN cord-354827-ipg1vwmv 93 14 , , , cord-354827-ipg1vwmv 93 15 how how WRB cord-354827-ipg1vwmv 93 16 might may MD cord-354827-ipg1vwmv 93 17 we -PRON- PRP cord-354827-ipg1vwmv 93 18 improve improve VB cord-354827-ipg1vwmv 93 19 approaches approach NNS cord-354827-ipg1vwmv 93 20 to to TO cord-354827-ipg1vwmv 93 21 direct direct JJ cord-354827-ipg1vwmv 93 22 culture culture NN cord-354827-ipg1vwmv 93 23 ? ? . cord-354827-ipg1vwmv 94 1 Could Could MD cord-354827-ipg1vwmv 94 2 S. S. NNP cord-354827-ipg1vwmv 94 3 Typhi Typhi NNP cord-354827-ipg1vwmv 94 4 culture culture NN cord-354827-ipg1vwmv 94 5 be be VB cord-354827-ipg1vwmv 94 6 further further RB cord-354827-ipg1vwmv 94 7 optimized optimize VBN cord-354827-ipg1vwmv 94 8 , , , cord-354827-ipg1vwmv 94 9 by by IN cord-354827-ipg1vwmv 94 10 taking take VBG cord-354827-ipg1vwmv 94 11 advantage advantage NN cord-354827-ipg1vwmv 94 12 of of IN cord-354827-ipg1vwmv 94 13 some some DT cord-354827-ipg1vwmv 94 14 atypical atypical JJ cord-354827-ipg1vwmv 94 15 biochemical biochemical JJ cord-354827-ipg1vwmv 94 16 properties property NNS cord-354827-ipg1vwmv 94 17 of of IN cord-354827-ipg1vwmv 94 18 the the DT cord-354827-ipg1vwmv 94 19 organism organism NN cord-354827-ipg1vwmv 94 20 ? ? . cord-354827-ipg1vwmv 95 1 Examination examination NN cord-354827-ipg1vwmv 95 2 of of IN cord-354827-ipg1vwmv 95 3 the the DT cord-354827-ipg1vwmv 95 4 S. S. NNP cord-354827-ipg1vwmv 95 5 Typhi Typhi NNP cord-354827-ipg1vwmv 95 6 genome genome NN cord-354827-ipg1vwmv 95 7 highlights highlight VBZ cord-354827-ipg1vwmv 95 8 metabolic metabolic JJ cord-354827-ipg1vwmv 95 9 and and CC cord-354827-ipg1vwmv 95 10 scavenging scavenge VBG cord-354827-ipg1vwmv 95 11 pathways pathway NNS cord-354827-ipg1vwmv 95 12 inactivated inactivate VBN cord-354827-ipg1vwmv 95 13 by by IN cord-354827-ipg1vwmv 95 14 the the DT cord-354827-ipg1vwmv 95 15 accumulation accumulation NN cord-354827-ipg1vwmv 95 16 of of IN cord-354827-ipg1vwmv 95 17 pseudogenes pseudogene NNS cord-354827-ipg1vwmv 95 18 [ [ -LRB- cord-354827-ipg1vwmv 95 19 18 18 CD cord-354827-ipg1vwmv 95 20 ] ] -RRB- cord-354827-ipg1vwmv 95 21 . . . cord-354827-ipg1vwmv 96 1 Examples example NNS cord-354827-ipg1vwmv 96 2 include include VBP cord-354827-ipg1vwmv 96 3 the the DT cord-354827-ipg1vwmv 96 4 cobalamin cobalamin NN cord-354827-ipg1vwmv 96 5 pathway pathway NN cord-354827-ipg1vwmv 96 6 , , , cord-354827-ipg1vwmv 96 7 many many JJ cord-354827-ipg1vwmv 96 8 metabolic metabolic JJ cord-354827-ipg1vwmv 96 9 transporters transporter NNS cord-354827-ipg1vwmv 96 10 and and CC cord-354827-ipg1vwmv 96 11 iron iron NN cord-354827-ipg1vwmv 96 12 uptake uptake NN cord-354827-ipg1vwmv 96 13 systems system NNS cord-354827-ipg1vwmv 96 14 . . . cord-354827-ipg1vwmv 97 1 Understanding understand VBG cord-354827-ipg1vwmv 97 2 specific specific JJ cord-354827-ipg1vwmv 97 3 biochemical biochemical JJ cord-354827-ipg1vwmv 97 4 pathways pathway NNS cord-354827-ipg1vwmv 97 5 that that WDT cord-354827-ipg1vwmv 97 6 are be VBP cord-354827-ipg1vwmv 97 7 up up RB cord-354827-ipg1vwmv 97 8 - - HYPH cord-354827-ipg1vwmv 97 9 regulated regulate VBN cord-354827-ipg1vwmv 97 10 under under IN cord-354827-ipg1vwmv 97 11 defined define VBN cord-354827-ipg1vwmv 97 12 conditions condition NNS cord-354827-ipg1vwmv 97 13 may may MD cord-354827-ipg1vwmv 97 14 permit permit VB cord-354827-ipg1vwmv 97 15 some some DT cord-354827-ipg1vwmv 97 16 modeling modeling NN cord-354827-ipg1vwmv 97 17 of of IN cord-354827-ipg1vwmv 97 18 conditions condition NNS cord-354827-ipg1vwmv 97 19 in in IN cord-354827-ipg1vwmv 97 20 which which WDT cord-354827-ipg1vwmv 97 21 S. S. NNP cord-354827-ipg1vwmv 97 22 Typhi Typhi NNP cord-354827-ipg1vwmv 97 23 can can MD cord-354827-ipg1vwmv 97 24 be be VB cord-354827-ipg1vwmv 97 25 grown grow VBN cord-354827-ipg1vwmv 97 26 more more RBR cord-354827-ipg1vwmv 97 27 efficiently efficiently RB cord-354827-ipg1vwmv 97 28 . . . cord-354827-ipg1vwmv 98 1 In in IN cord-354827-ipg1vwmv 98 2 short short JJ cord-354827-ipg1vwmv 98 3 , , , cord-354827-ipg1vwmv 98 4 could could MD cord-354827-ipg1vwmv 98 5 we -PRON- PRP cord-354827-ipg1vwmv 98 6 use use VB cord-354827-ipg1vwmv 98 7 a a DT cord-354827-ipg1vwmv 98 8 method method NN cord-354827-ipg1vwmv 98 9 that that WDT cord-354827-ipg1vwmv 98 10 we -PRON- PRP cord-354827-ipg1vwmv 98 11 define define VBP cord-354827-ipg1vwmv 98 12 as as IN cord-354827-ipg1vwmv 98 13 " " `` cord-354827-ipg1vwmv 98 14 metabolomic metabolomic NN cord-354827-ipg1vwmv 98 15 modeling modeling NN cord-354827-ipg1vwmv 98 16 " " '' cord-354827-ipg1vwmv 98 17 to to TO cord-354827-ipg1vwmv 98 18 design design VB cord-354827-ipg1vwmv 98 19 recovery recovery NN cord-354827-ipg1vwmv 98 20 media medium NNS cord-354827-ipg1vwmv 98 21 to to TO cord-354827-ipg1vwmv 98 22 enrich enrich VB cord-354827-ipg1vwmv 98 23 for for IN cord-354827-ipg1vwmv 98 24 S. S. NNP cord-354827-ipg1vwmv 98 25 Typhi Typhi NNP cord-354827-ipg1vwmv 98 26 ? ? . cord-354827-ipg1vwmv 99 1 This this DT cord-354827-ipg1vwmv 99 2 approach approach NN cord-354827-ipg1vwmv 99 3 is be VBZ cord-354827-ipg1vwmv 99 4 certainly certainly RB cord-354827-ipg1vwmv 99 5 worth worth JJ cord-354827-ipg1vwmv 99 6 considering consider VBG cord-354827-ipg1vwmv 99 7 but but CC cord-354827-ipg1vwmv 99 8 may may MD cord-354827-ipg1vwmv 99 9 only only RB cord-354827-ipg1vwmv 99 10 have have VB cord-354827-ipg1vwmv 99 11 a a DT cord-354827-ipg1vwmv 99 12 marginal marginal JJ cord-354827-ipg1vwmv 99 13 effect effect NN cord-354827-ipg1vwmv 99 14 on on IN cord-354827-ipg1vwmv 99 15 bacterial bacterial JJ cord-354827-ipg1vwmv 99 16 recovery recovery NN cord-354827-ipg1vwmv 99 17 . . . cord-354827-ipg1vwmv 100 1 Ultimately ultimately RB cord-354827-ipg1vwmv 100 2 , , , cord-354827-ipg1vwmv 100 3 the the DT cord-354827-ipg1vwmv 100 4 low low JJ cord-354827-ipg1vwmv 100 5 level level NN cord-354827-ipg1vwmv 100 6 of of IN cord-354827-ipg1vwmv 100 7 bacteria bacteria NNS cord-354827-ipg1vwmv 100 8 in in IN cord-354827-ipg1vwmv 100 9 the the DT cord-354827-ipg1vwmv 100 10 sample sample NN cord-354827-ipg1vwmv 100 11 may may MD cord-354827-ipg1vwmv 100 12 set set VB cord-354827-ipg1vwmv 100 13 an an DT cord-354827-ipg1vwmv 100 14 impenetrable impenetrable JJ cord-354827-ipg1vwmv 100 15 practical practical JJ cord-354827-ipg1vwmv 100 16 barrier barrier NN cord-354827-ipg1vwmv 100 17 which which WDT cord-354827-ipg1vwmv 100 18 may may MD cord-354827-ipg1vwmv 100 19 only only RB cord-354827-ipg1vwmv 100 20 be be VB cord-354827-ipg1vwmv 100 21 circumvented circumvent VBN cord-354827-ipg1vwmv 100 22 by by IN cord-354827-ipg1vwmv 100 23 purification purification NN cord-354827-ipg1vwmv 100 24 or or CC cord-354827-ipg1vwmv 100 25 enrichment enrichment NN cord-354827-ipg1vwmv 100 26 technology technology NN cord-354827-ipg1vwmv 100 27 . . . cord-354827-ipg1vwmv 101 1 The the DT cord-354827-ipg1vwmv 101 2 culturing culturing NN cord-354827-ipg1vwmv 101 3 of of IN cord-354827-ipg1vwmv 101 4 bone bone NN cord-354827-ipg1vwmv 101 5 marrow marrow NN cord-354827-ipg1vwmv 101 6 biopsies biopsy NNS cord-354827-ipg1vwmv 101 7 is be VBZ cord-354827-ipg1vwmv 101 8 more more RBR cord-354827-ipg1vwmv 101 9 sensitive sensitive JJ cord-354827-ipg1vwmv 101 10 than than IN cord-354827-ipg1vwmv 101 11 that that DT cord-354827-ipg1vwmv 101 12 of of IN cord-354827-ipg1vwmv 101 13 blood blood NN cord-354827-ipg1vwmv 101 14 culture culture NN cord-354827-ipg1vwmv 101 15 and and CC cord-354827-ipg1vwmv 101 16 a a DT cord-354827-ipg1vwmv 101 17 modified modify VBN cord-354827-ipg1vwmv 101 18 technique technique NN cord-354827-ipg1vwmv 101 19 to to TO cord-354827-ipg1vwmv 101 20 take take VB cord-354827-ipg1vwmv 101 21 bone bone NN cord-354827-ipg1vwmv 101 22 marrow marrow NN cord-354827-ipg1vwmv 101 23 in in IN cord-354827-ipg1vwmv 101 24 a a DT cord-354827-ipg1vwmv 101 25 more more RBR cord-354827-ipg1vwmv 101 26 straightforward straightforward JJ cord-354827-ipg1vwmv 101 27 and and CC cord-354827-ipg1vwmv 101 28 somewhat somewhat RB cord-354827-ipg1vwmv 101 29 less less RBR cord-354827-ipg1vwmv 101 30 brutal brutal JJ cord-354827-ipg1vwmv 101 31 manner manner NN cord-354827-ipg1vwmv 101 32 would would MD cord-354827-ipg1vwmv 101 33 be be VB cord-354827-ipg1vwmv 101 34 desirable desirable JJ cord-354827-ipg1vwmv 101 35 [ [ -LRB- cord-354827-ipg1vwmv 101 36 29 29 CD cord-354827-ipg1vwmv 101 37 ] ] -RRB- cord-354827-ipg1vwmv 101 38 . . . cord-354827-ipg1vwmv 102 1 The the DT cord-354827-ipg1vwmv 102 2 first first JJ cord-354827-ipg1vwmv 102 3 typhoid typhoid NN cord-354827-ipg1vwmv 102 4 diagnostic diagnostic JJ cord-354827-ipg1vwmv 102 5 , , , cord-354827-ipg1vwmv 102 6 the the DT cord-354827-ipg1vwmv 102 7 Widal Widal NNP cord-354827-ipg1vwmv 102 8 test test NN cord-354827-ipg1vwmv 102 9 , , , cord-354827-ipg1vwmv 102 10 was be VBD cord-354827-ipg1vwmv 102 11 developed develop VBN cord-354827-ipg1vwmv 102 12 in in IN cord-354827-ipg1vwmv 102 13 1896 1896 CD cord-354827-ipg1vwmv 102 14 . . . cord-354827-ipg1vwmv 103 1 The the DT cord-354827-ipg1vwmv 103 2 methodology methodology NN cord-354827-ipg1vwmv 103 3 is be VBZ cord-354827-ipg1vwmv 103 4 dependent dependent JJ cord-354827-ipg1vwmv 103 5 on on IN cord-354827-ipg1vwmv 103 6 agglutination agglutination NN cord-354827-ipg1vwmv 103 7 ; ; : cord-354827-ipg1vwmv 103 8 S. S. NNP cord-354827-ipg1vwmv 103 9 Typhi Typhi NNP cord-354827-ipg1vwmv 103 10 cells cell NNS cord-354827-ipg1vwmv 103 11 are be VBP cord-354827-ipg1vwmv 103 12 used use VBN cord-354827-ipg1vwmv 103 13 to to TO cord-354827-ipg1vwmv 103 14 detect detect VB cord-354827-ipg1vwmv 103 15 antibodies antibody NNS cord-354827-ipg1vwmv 103 16 in in IN cord-354827-ipg1vwmv 103 17 blood blood NN cord-354827-ipg1vwmv 103 18 . . . cord-354827-ipg1vwmv 104 1 This this DT cord-354827-ipg1vwmv 104 2 crude crude JJ cord-354827-ipg1vwmv 104 3 assay assay NN cord-354827-ipg1vwmv 104 4 is be VBZ cord-354827-ipg1vwmv 104 5 a a DT cord-354827-ipg1vwmv 104 6 visual visual JJ cord-354827-ipg1vwmv 104 7 test test NN cord-354827-ipg1vwmv 104 8 that that WDT cord-354827-ipg1vwmv 104 9 monitors monitor VBZ cord-354827-ipg1vwmv 104 10 agglutinating agglutinate VBG cord-354827-ipg1vwmv 104 11 antibodies antibody NNS cord-354827-ipg1vwmv 104 12 that that WDT cord-354827-ipg1vwmv 104 13 react react VBP cord-354827-ipg1vwmv 104 14 with with IN cord-354827-ipg1vwmv 104 15 S. S. NNP cord-354827-ipg1vwmv 104 16 Typhi Typhi NNP cord-354827-ipg1vwmv 104 17 [ [ -LRB- cord-354827-ipg1vwmv 104 18 30 30 CD cord-354827-ipg1vwmv 104 19 ] ] -RRB- cord-354827-ipg1vwmv 104 20 . . . cord-354827-ipg1vwmv 105 1 Problems problem NNS cord-354827-ipg1vwmv 105 2 associated associate VBN cord-354827-ipg1vwmv 105 3 with with IN cord-354827-ipg1vwmv 105 4 the the DT cord-354827-ipg1vwmv 105 5 use use NN cord-354827-ipg1vwmv 105 6 of of IN cord-354827-ipg1vwmv 105 7 Widal Widal NNP cord-354827-ipg1vwmv 105 8 are be VBP cord-354827-ipg1vwmv 105 9 somewhat somewhat RB cord-354827-ipg1vwmv 105 10 obvious obvious JJ cord-354827-ipg1vwmv 105 11 and and CC cord-354827-ipg1vwmv 105 12 may may MD cord-354827-ipg1vwmv 105 13 apply apply VB cord-354827-ipg1vwmv 105 14 to to IN cord-354827-ipg1vwmv 105 15 other other JJ cord-354827-ipg1vwmv 105 16 serologically serologically RB cord-354827-ipg1vwmv 105 17 based base VBN cord-354827-ipg1vwmv 105 18 assays assay NNS cord-354827-ipg1vwmv 105 19 for for IN cord-354827-ipg1vwmv 105 20 typhoid typhoid NN cord-354827-ipg1vwmv 105 21 . . . cord-354827-ipg1vwmv 106 1 S. S. NNP cord-354827-ipg1vwmv 106 2 Typhi Typhi NNP cord-354827-ipg1vwmv 106 3 is be VBZ cord-354827-ipg1vwmv 106 4 a a DT cord-354827-ipg1vwmv 106 5 relatively relatively RB cord-354827-ipg1vwmv 106 6 invariant invariant JJ cord-354827-ipg1vwmv 106 7 pathogen pathogen NN cord-354827-ipg1vwmv 106 8 so so RB cord-354827-ipg1vwmv 106 9 antigenic antigenic JJ cord-354827-ipg1vwmv 106 10 variation variation NN cord-354827-ipg1vwmv 106 11 per per FW cord-354827-ipg1vwmv 106 12 se se FW cord-354827-ipg1vwmv 106 13 should should MD cord-354827-ipg1vwmv 106 14 not not RB cord-354827-ipg1vwmv 106 15 be be VB cord-354827-ipg1vwmv 106 16 a a DT cord-354827-ipg1vwmv 106 17 significant significant JJ cord-354827-ipg1vwmv 106 18 confounder confounder NN cord-354827-ipg1vwmv 106 19 . . . cord-354827-ipg1vwmv 107 1 However however RB cord-354827-ipg1vwmv 107 2 , , , cord-354827-ipg1vwmv 107 3 S. S. NNP cord-354827-ipg1vwmv 107 4 Typhi Typhi NNP cord-354827-ipg1vwmv 107 5 is be VBZ cord-354827-ipg1vwmv 107 6 a a DT cord-354827-ipg1vwmv 107 7 member member NN cord-354827-ipg1vwmv 107 8 of of IN cord-354827-ipg1vwmv 107 9 the the DT cord-354827-ipg1vwmv 107 10 Enterobacteriaceae Enterobacteriaceae NNP cord-354827-ipg1vwmv 107 11 . . . cord-354827-ipg1vwmv 108 1 Many many JJ cord-354827-ipg1vwmv 108 2 of of IN cord-354827-ipg1vwmv 108 3 the the DT cord-354827-ipg1vwmv 108 4 surface surface NN cord-354827-ipg1vwmv 108 5 antigens antigen NNS cord-354827-ipg1vwmv 108 6 of of IN cord-354827-ipg1vwmv 108 7 the the DT cord-354827-ipg1vwmv 108 8 Enterobacteriaceae Enterobacteriaceae NNP cord-354827-ipg1vwmv 108 9 demonstrate demonstrate VBP cord-354827-ipg1vwmv 108 10 significant significant JJ cord-354827-ipg1vwmv 108 11 conservation conservation NN cord-354827-ipg1vwmv 108 12 and and CC cord-354827-ipg1vwmv 108 13 induce induce VB cord-354827-ipg1vwmv 108 14 antibodies antibody NNS cord-354827-ipg1vwmv 108 15 that that WDT cord-354827-ipg1vwmv 108 16 are be VBP cord-354827-ipg1vwmv 108 17 cross cross JJ cord-354827-ipg1vwmv 108 18 - - JJ cord-354827-ipg1vwmv 108 19 reactive reactive JJ cord-354827-ipg1vwmv 108 20 . . . cord-354827-ipg1vwmv 109 1 Consequently consequently RB cord-354827-ipg1vwmv 109 2 , , , cord-354827-ipg1vwmv 109 3 as as IN cord-354827-ipg1vwmv 109 4 humans human NNS cord-354827-ipg1vwmv 109 5 mature mature VBP cord-354827-ipg1vwmv 109 6 they -PRON- PRP cord-354827-ipg1vwmv 109 7 accumulate accumulate VBP cord-354827-ipg1vwmv 109 8 antibodies antibody NNS cord-354827-ipg1vwmv 109 9 that that WDT cord-354827-ipg1vwmv 109 10 are be VBP cord-354827-ipg1vwmv 109 11 cross cross JJ cord-354827-ipg1vwmv 109 12 - - JJ cord-354827-ipg1vwmv 109 13 reactive reactive JJ cord-354827-ipg1vwmv 109 14 with with IN cord-354827-ipg1vwmv 109 15 S. S. NNP cord-354827-ipg1vwmv 109 16 Typhi Typhi NNP cord-354827-ipg1vwmv 109 17 . . . cord-354827-ipg1vwmv 110 1 Thus thus RB cord-354827-ipg1vwmv 110 2 , , , cord-354827-ipg1vwmv 110 3 it -PRON- PRP cord-354827-ipg1vwmv 110 4 may may MD cord-354827-ipg1vwmv 110 5 be be VB cord-354827-ipg1vwmv 110 6 impossible impossible JJ cord-354827-ipg1vwmv 110 7 to to TO cord-354827-ipg1vwmv 110 8 develop develop VB cord-354827-ipg1vwmv 110 9 a a DT cord-354827-ipg1vwmv 110 10 specific specific JJ cord-354827-ipg1vwmv 110 11 diagnostic diagnostic JJ cord-354827-ipg1vwmv 110 12 kit kit NN cord-354827-ipg1vwmv 110 13 for for IN cord-354827-ipg1vwmv 110 14 typhoid typhoid NN cord-354827-ipg1vwmv 110 15 using use VBG cord-354827-ipg1vwmv 110 16 semi semi RB cord-354827-ipg1vwmv 110 17 - - JJ cord-354827-ipg1vwmv 110 18 purified purify VBN cord-354827-ipg1vwmv 110 19 antigens antigen NNS cord-354827-ipg1vwmv 110 20 . . . cord-354827-ipg1vwmv 111 1 Indeed indeed RB cord-354827-ipg1vwmv 111 2 , , , cord-354827-ipg1vwmv 111 3 any any DT cord-354827-ipg1vwmv 111 4 such such JJ cord-354827-ipg1vwmv 111 5 kit kit NN cord-354827-ipg1vwmv 111 6 would would MD cord-354827-ipg1vwmv 111 7 likely likely RB cord-354827-ipg1vwmv 111 8 yield yield VB cord-354827-ipg1vwmv 111 9 significant significant JJ cord-354827-ipg1vwmv 111 10 false false JJ cord-354827-ipg1vwmv 111 11 positives positive NNS cord-354827-ipg1vwmv 111 12 . . . cord-354827-ipg1vwmv 112 1 S. S. NNP cord-354827-ipg1vwmv 112 2 Typhi Typhi NNP cord-354827-ipg1vwmv 112 3 expresses express VBZ cord-354827-ipg1vwmv 112 4 a a DT cord-354827-ipg1vwmv 112 5 number number NN cord-354827-ipg1vwmv 112 6 of of IN cord-354827-ipg1vwmv 112 7 immunogenic immunogenic JJ cord-354827-ipg1vwmv 112 8 structures structure NNS cord-354827-ipg1vwmv 112 9 on on IN cord-354827-ipg1vwmv 112 10 the the DT cord-354827-ipg1vwmv 112 11 surface surface NN cord-354827-ipg1vwmv 112 12 , , , cord-354827-ipg1vwmv 112 13 some some DT cord-354827-ipg1vwmv 112 14 of of IN cord-354827-ipg1vwmv 112 15 which which WDT cord-354827-ipg1vwmv 112 16 provide provide VBP cord-354827-ipg1vwmv 112 17 a a DT cord-354827-ipg1vwmv 112 18 basis basis NN cord-354827-ipg1vwmv 112 19 for for IN cord-354827-ipg1vwmv 112 20 serology serology NN cord-354827-ipg1vwmv 112 21 identification identification NN cord-354827-ipg1vwmv 112 22 . . . cord-354827-ipg1vwmv 113 1 These these DT cord-354827-ipg1vwmv 113 2 include include VBP cord-354827-ipg1vwmv 113 3 O o NN cord-354827-ipg1vwmv 113 4 ( ( -LRB- cord-354827-ipg1vwmv 113 5 lipopolysaccharide lipopolysaccharide NN cord-354827-ipg1vwmv 113 6 ) ) -RRB- cord-354827-ipg1vwmv 113 7 , , , cord-354827-ipg1vwmv 113 8 H H NNP cord-354827-ipg1vwmv 113 9 ( ( -LRB- cord-354827-ipg1vwmv 113 10 flagella flagellum NNS cord-354827-ipg1vwmv 113 11 ) ) -RRB- cord-354827-ipg1vwmv 113 12 and and CC cord-354827-ipg1vwmv 113 13 the the DT cord-354827-ipg1vwmv 113 14 somewhat somewhat RB cord-354827-ipg1vwmv 113 15 less less RBR cord-354827-ipg1vwmv 113 16 immunogenic immunogenic JJ cord-354827-ipg1vwmv 113 17 Vi Vi NNP cord-354827-ipg1vwmv 113 18 capsule capsule NN cord-354827-ipg1vwmv 113 19 . . . cord-354827-ipg1vwmv 114 1 S. S. NNP cord-354827-ipg1vwmv 114 2 Typhi Typhi NNP cord-354827-ipg1vwmv 114 3 exhibiting exhibit VBG cord-354827-ipg1vwmv 114 4 variation variation NN cord-354827-ipg1vwmv 114 5 in in IN cord-354827-ipg1vwmv 114 6 these these DT cord-354827-ipg1vwmv 114 7 antigens antigen NNS cord-354827-ipg1vwmv 114 8 are be VBP cord-354827-ipg1vwmv 114 9 uncommon uncommon JJ cord-354827-ipg1vwmv 114 10 , , , cord-354827-ipg1vwmv 114 11 with with IN cord-354827-ipg1vwmv 114 12 notable notable JJ cord-354827-ipg1vwmv 114 13 exceptions exception NNS cord-354827-ipg1vwmv 114 14 . . . cord-354827-ipg1vwmv 115 1 S. S. NNP cord-354827-ipg1vwmv 115 2 Typhi Typhi NNP cord-354827-ipg1vwmv 115 3 found find VBD cord-354827-ipg1vwmv 115 4 in in IN cord-354827-ipg1vwmv 115 5 Indonesia Indonesia NNP cord-354827-ipg1vwmv 115 6 express express JJ cord-354827-ipg1vwmv 115 7 variant variant NN cord-354827-ipg1vwmv 115 8 H h NN cord-354827-ipg1vwmv 115 9 antigens antigen NNS cord-354827-ipg1vwmv 115 10 including include VBG cord-354827-ipg1vwmv 115 11 H h NN cord-354827-ipg1vwmv 115 12 : : : cord-354827-ipg1vwmv 115 13 j j NNP cord-354827-ipg1vwmv 115 14 and and CC cord-354827-ipg1vwmv 115 15 H H NNP cord-354827-ipg1vwmv 115 16 : : : cord-354827-ipg1vwmv 115 17 z66 z66 ADD cord-354827-ipg1vwmv 115 18 [ [ -LRB- cord-354827-ipg1vwmv 115 19 31 31 CD cord-354827-ipg1vwmv 115 20 ] ] -RRB- cord-354827-ipg1vwmv 116 1 [ [ -LRB- cord-354827-ipg1vwmv 116 2 32 32 CD cord-354827-ipg1vwmv 116 3 ] ] -RRB- cord-354827-ipg1vwmv 116 4 [ [ -LRB- cord-354827-ipg1vwmv 116 5 33 33 CD cord-354827-ipg1vwmv 116 6 ] ] -RRB- cord-354827-ipg1vwmv 116 7 [ [ -LRB- cord-354827-ipg1vwmv 116 8 34 34 CD cord-354827-ipg1vwmv 116 9 ] ] -RRB- cord-354827-ipg1vwmv 116 10 . . . cord-354827-ipg1vwmv 117 1 Vi Vi NNP cord-354827-ipg1vwmv 117 2 - - HYPH cord-354827-ipg1vwmv 117 3 negative negative JJ cord-354827-ipg1vwmv 117 4 S. S. NNP cord-354827-ipg1vwmv 117 5 Typhi Typhi NNP cord-354827-ipg1vwmv 117 6 isolates isolate NNS cord-354827-ipg1vwmv 117 7 have have VBP cord-354827-ipg1vwmv 117 8 been be VBN cord-354827-ipg1vwmv 117 9 reported report VBN cord-354827-ipg1vwmv 117 10 in in IN cord-354827-ipg1vwmv 117 11 Pakistan Pakistan NNP cord-354827-ipg1vwmv 117 12 but but CC cord-354827-ipg1vwmv 117 13 are be VBP cord-354827-ipg1vwmv 117 14 rare rare JJ cord-354827-ipg1vwmv 117 15 [ [ -LRB- cord-354827-ipg1vwmv 117 16 35 35 CD cord-354827-ipg1vwmv 117 17 , , , cord-354827-ipg1vwmv 117 18 36 36 CD cord-354827-ipg1vwmv 117 19 ] ] -RRB- cord-354827-ipg1vwmv 117 20 . . . cord-354827-ipg1vwmv 118 1 Therefore therefore RB cord-354827-ipg1vwmv 118 2 , , , cord-354827-ipg1vwmv 118 3 S. S. NNP cord-354827-ipg1vwmv 118 4 Typhi Typhi NNP cord-354827-ipg1vwmv 118 5 expressing express VBG cord-354827-ipg1vwmv 118 6 O O NNP cord-354827-ipg1vwmv 118 7 ( ( -LRB- cord-354827-ipg1vwmv 118 8 O9 o9 NN cord-354827-ipg1vwmv 118 9 , , , cord-354827-ipg1vwmv 118 10 O12 O12 NNP cord-354827-ipg1vwmv 118 11 ) ) -RRB- cord-354827-ipg1vwmv 118 12 , , , cord-354827-ipg1vwmv 118 13 Vi Vi NNP cord-354827-ipg1vwmv 118 14 and and CC cord-354827-ipg1vwmv 118 15 H h NN cord-354827-ipg1vwmv 118 16 : : : cord-354827-ipg1vwmv 119 1 d d NNP cord-354827-ipg1vwmv 119 2 are be VBP cord-354827-ipg1vwmv 119 3 ubiquitous ubiquitous JJ cord-354827-ipg1vwmv 119 4 in in IN cord-354827-ipg1vwmv 119 5 most most JJS cord-354827-ipg1vwmv 119 6 endemic endemic JJ cord-354827-ipg1vwmv 119 7 areas area NNS cord-354827-ipg1vwmv 119 8 . . . cord-354827-ipg1vwmv 120 1 Seroprevalence Seroprevalence NNP cord-354827-ipg1vwmv 120 2 studies study NNS cord-354827-ipg1vwmv 120 3 have have VBP cord-354827-ipg1vwmv 120 4 been be VBN cord-354827-ipg1vwmv 120 5 performed perform VBN cord-354827-ipg1vwmv 120 6 in in IN cord-354827-ipg1vwmv 120 7 endemic endemic JJ cord-354827-ipg1vwmv 120 8 regions region NNS cord-354827-ipg1vwmv 120 9 to to TO cord-354827-ipg1vwmv 120 10 determine determine VB cord-354827-ipg1vwmv 120 11 antibody antibody NN cord-354827-ipg1vwmv 120 12 titers titer NNS cord-354827-ipg1vwmv 120 13 to to IN cord-354827-ipg1vwmv 120 14 O o NN cord-354827-ipg1vwmv 120 15 , , , cord-354827-ipg1vwmv 120 16 H H NNP cord-354827-ipg1vwmv 120 17 and and CC cord-354827-ipg1vwmv 120 18 Vi Vi NNP cord-354827-ipg1vwmv 120 19 in in IN cord-354827-ipg1vwmv 120 20 the the DT cord-354827-ipg1vwmv 120 21 general general JJ cord-354827-ipg1vwmv 120 22 population population NN cord-354827-ipg1vwmv 120 23 [ [ -LRB- cord-354827-ipg1vwmv 120 24 26 26 CD cord-354827-ipg1vwmv 120 25 , , , cord-354827-ipg1vwmv 120 26 37 37 CD cord-354827-ipg1vwmv 120 27 ] ] -RRB- cord-354827-ipg1vwmv 120 28 . . . cord-354827-ipg1vwmv 121 1 Many many JJ cord-354827-ipg1vwmv 121 2 individuals individual NNS cord-354827-ipg1vwmv 121 3 in in IN cord-354827-ipg1vwmv 121 4 endemic endemic JJ cord-354827-ipg1vwmv 121 5 areas area NNS cord-354827-ipg1vwmv 121 6 have have VBP cord-354827-ipg1vwmv 121 7 cross cross JJ cord-354827-ipg1vwmv 121 8 - - JJ cord-354827-ipg1vwmv 121 9 reactive reactive JJ cord-354827-ipg1vwmv 121 10 antibodies antibody NNS cord-354827-ipg1vwmv 121 11 even even RB cord-354827-ipg1vwmv 121 12 though though IN cord-354827-ipg1vwmv 121 13 they -PRON- PRP cord-354827-ipg1vwmv 121 14 have have VBP cord-354827-ipg1vwmv 121 15 no no DT cord-354827-ipg1vwmv 121 16 clinical clinical JJ cord-354827-ipg1vwmv 121 17 record record NN cord-354827-ipg1vwmv 121 18 of of IN cord-354827-ipg1vwmv 121 19 typhoid typhoid NN cord-354827-ipg1vwmv 121 20 . . . cord-354827-ipg1vwmv 122 1 Additionally additionally RB cord-354827-ipg1vwmv 122 2 , , , cord-354827-ipg1vwmv 122 3 such such JJ cord-354827-ipg1vwmv 122 4 raised raise VBN cord-354827-ipg1vwmv 122 5 antibody antibody NN cord-354827-ipg1vwmv 122 6 levels level NNS cord-354827-ipg1vwmv 122 7 frequently frequently RB cord-354827-ipg1vwmv 122 8 can can MD cord-354827-ipg1vwmv 122 9 not not RB cord-354827-ipg1vwmv 122 10 be be VB cord-354827-ipg1vwmv 122 11 detected detect VBN cord-354827-ipg1vwmv 122 12 in in IN cord-354827-ipg1vwmv 122 13 patients patient NNS cord-354827-ipg1vwmv 122 14 with with IN cord-354827-ipg1vwmv 122 15 culture culture NN cord-354827-ipg1vwmv 122 16 confirmed confirm VBD cord-354827-ipg1vwmv 122 17 typhoid typhoid NN cord-354827-ipg1vwmv 122 18 . . . cord-354827-ipg1vwmv 123 1 Problems problem NNS cord-354827-ipg1vwmv 123 2 have have VBP cord-354827-ipg1vwmv 123 3 also also RB cord-354827-ipg1vwmv 123 4 been be VBN cord-354827-ipg1vwmv 123 5 encountered encounter VBN cord-354827-ipg1vwmv 123 6 during during IN cord-354827-ipg1vwmv 123 7 the the DT cord-354827-ipg1vwmv 123 8 testing testing NN cord-354827-ipg1vwmv 123 9 of of IN cord-354827-ipg1vwmv 123 10 commercial commercial JJ cord-354827-ipg1vwmv 123 11 serological serological JJ cord-354827-ipg1vwmv 123 12 tests test NNS cord-354827-ipg1vwmv 123 13 , , , cord-354827-ipg1vwmv 123 14 including include VBG cord-354827-ipg1vwmv 123 15 Typhidot Typhidot NNP cord-354827-ipg1vwmv 123 16 and and CC cord-354827-ipg1vwmv 123 17 Tubex Tubex NNP cord-354827-ipg1vwmv 123 18 [ [ -LRB- cord-354827-ipg1vwmv 123 19 38 38 CD cord-354827-ipg1vwmv 123 20 , , , cord-354827-ipg1vwmv 123 21 39 39 CD cord-354827-ipg1vwmv 123 22 ] ] -RRB- cord-354827-ipg1vwmv 123 23 . . . cord-354827-ipg1vwmv 124 1 These these DT cord-354827-ipg1vwmv 124 2 assays assay NNS cord-354827-ipg1vwmv 124 3 were be VBD cord-354827-ipg1vwmv 124 4 assessed assess VBN cord-354827-ipg1vwmv 124 5 in in IN cord-354827-ipg1vwmv 124 6 population population NN cord-354827-ipg1vwmv 124 7 - - HYPH cord-354827-ipg1vwmv 124 8 based base VBN cord-354827-ipg1vwmv 124 9 typhoid typhoid NN cord-354827-ipg1vwmv 124 10 surveillance surveillance NN cord-354827-ipg1vwmv 124 11 studies study NNS cord-354827-ipg1vwmv 124 12 in in IN cord-354827-ipg1vwmv 124 13 several several JJ cord-354827-ipg1vwmv 124 14 countries country NNS cord-354827-ipg1vwmv 124 15 and and CC cord-354827-ipg1vwmv 124 16 in in IN cord-354827-ipg1vwmv 124 17 all all DT cord-354827-ipg1vwmv 124 18 locations location NNS cord-354827-ipg1vwmv 124 19 the the DT cord-354827-ipg1vwmv 124 20 sensitivity sensitivity NN cord-354827-ipg1vwmv 124 21 and and CC cord-354827-ipg1vwmv 124 22 specificity specificity NN cord-354827-ipg1vwmv 124 23 for for IN cord-354827-ipg1vwmv 124 24 Tubex Tubex NNP cord-354827-ipg1vwmv 124 25 and and CC cord-354827-ipg1vwmv 124 26 Typhidot Typhidot NNP cord-354827-ipg1vwmv 124 27 was be VBD cord-354827-ipg1vwmv 124 28 only only RB cord-354827-ipg1vwmv 124 29 around around IN cord-354827-ipg1vwmv 124 30 70 70 CD cord-354827-ipg1vwmv 124 31 % % NN cord-354827-ipg1vwmv 124 32 and and CC cord-354827-ipg1vwmv 124 33 80 80 CD cord-354827-ipg1vwmv 124 34 % % NN cord-354827-ipg1vwmv 124 35 respectively respectively RB cord-354827-ipg1vwmv 124 36 [ [ -LRB- cord-354827-ipg1vwmv 124 37 40 40 CD cord-354827-ipg1vwmv 124 38 , , , cord-354827-ipg1vwmv 124 39 41 41 CD cord-354827-ipg1vwmv 124 40 ] ] -RRB- cord-354827-ipg1vwmv 124 41 . . . cord-354827-ipg1vwmv 125 1 Clearly clearly RB cord-354827-ipg1vwmv 125 2 the the DT cord-354827-ipg1vwmv 125 3 abundance abundance NN cord-354827-ipg1vwmv 125 4 and and CC cord-354827-ipg1vwmv 125 5 avidity avidity NN cord-354827-ipg1vwmv 125 6 of of IN cord-354827-ipg1vwmv 125 7 anti anti JJ cord-354827-ipg1vwmv 125 8 - - NNP cord-354827-ipg1vwmv 125 9 S. S. NNP cord-354827-ipg1vwmv 125 10 Typhi Typhi NNP cord-354827-ipg1vwmv 125 11 antibodies antibody NNS cord-354827-ipg1vwmv 125 12 varies vary VBZ cord-354827-ipg1vwmv 125 13 and and CC cord-354827-ipg1vwmv 125 14 it -PRON- PRP cord-354827-ipg1vwmv 125 15 is be VBZ cord-354827-ipg1vwmv 125 16 difficult difficult JJ cord-354827-ipg1vwmv 125 17 to to TO cord-354827-ipg1vwmv 125 18 imagine imagine VB cord-354827-ipg1vwmv 125 19 how how WRB cord-354827-ipg1vwmv 125 20 a a DT cord-354827-ipg1vwmv 125 21 clean clean JJ cord-354827-ipg1vwmv 125 22 diagnostic diagnostic JJ cord-354827-ipg1vwmv 125 23 assay assay NN cord-354827-ipg1vwmv 125 24 with with IN cord-354827-ipg1vwmv 125 25 high high JJ cord-354827-ipg1vwmv 125 26 specificity specificity NN cord-354827-ipg1vwmv 125 27 could could MD cord-354827-ipg1vwmv 125 28 be be VB cord-354827-ipg1vwmv 125 29 produced produce VBN cord-354827-ipg1vwmv 125 30 targeting target VBG cord-354827-ipg1vwmv 125 31 these these DT cord-354827-ipg1vwmv 125 32 classical classical JJ cord-354827-ipg1vwmv 125 33 antigens antigen NNS cord-354827-ipg1vwmv 125 34 . . . cord-354827-ipg1vwmv 126 1 Can Can MD cord-354827-ipg1vwmv 126 2 other other JJ cord-354827-ipg1vwmv 126 3 antigen antigen NN cord-354827-ipg1vwmv 126 4 / / SYM cord-354827-ipg1vwmv 126 5 antibody antibody NN cord-354827-ipg1vwmv 126 6 complexes complex NNS cord-354827-ipg1vwmv 126 7 be be VB cord-354827-ipg1vwmv 126 8 used use VBN cord-354827-ipg1vwmv 126 9 as as IN cord-354827-ipg1vwmv 126 10 more more RBR cord-354827-ipg1vwmv 126 11 accurate accurate JJ cord-354827-ipg1vwmv 126 12 diagnostics diagnostic NNS cord-354827-ipg1vwmv 126 13 ? ? . cord-354827-ipg1vwmv 127 1 This this DT cord-354827-ipg1vwmv 127 2 is be VBZ cord-354827-ipg1vwmv 127 3 an an DT cord-354827-ipg1vwmv 127 4 under under RB cord-354827-ipg1vwmv 127 5 - - HYPH cord-354827-ipg1vwmv 127 6 studied study VBN cord-354827-ipg1vwmv 127 7 area area NN cord-354827-ipg1vwmv 127 8 with with IN cord-354827-ipg1vwmv 127 9 few few JJ cord-354827-ipg1vwmv 127 10 S. S. NNP cord-354827-ipg1vwmv 127 11 Typhi Typhi NNP cord-354827-ipg1vwmv 127 12 specific specific JJ cord-354827-ipg1vwmv 127 13 antigens antigen NNS cord-354827-ipg1vwmv 127 14 being be VBG cord-354827-ipg1vwmv 127 15 investigated investigate VBN cord-354827-ipg1vwmv 127 16 in in IN cord-354827-ipg1vwmv 127 17 any any DT cord-354827-ipg1vwmv 127 18 detail detail NN cord-354827-ipg1vwmv 127 19 . . . cord-354827-ipg1vwmv 128 1 Experiments experiment NNS cord-354827-ipg1vwmv 128 2 utilizing utilize VBG cord-354827-ipg1vwmv 128 3 convalescent convalescent JJ cord-354827-ipg1vwmv 128 4 serum serum NN cord-354827-ipg1vwmv 128 5 from from IN cord-354827-ipg1vwmv 128 6 typhoid typhoid NN cord-354827-ipg1vwmv 128 7 patients patient NNS cord-354827-ipg1vwmv 128 8 , , , cord-354827-ipg1vwmv 128 9 indicates indicate VBZ cord-354827-ipg1vwmv 128 10 that that IN cord-354827-ipg1vwmv 128 11 individuals individual NNS cord-354827-ipg1vwmv 128 12 can can MD cord-354827-ipg1vwmv 128 13 respond respond VB cord-354827-ipg1vwmv 128 14 to to IN cord-354827-ipg1vwmv 128 15 a a DT cord-354827-ipg1vwmv 128 16 range range NN cord-354827-ipg1vwmv 128 17 of of IN cord-354827-ipg1vwmv 128 18 S. S. NNP cord-354827-ipg1vwmv 128 19 Typhi Typhi NNP cord-354827-ipg1vwmv 128 20 antigens antigen NNS cord-354827-ipg1vwmv 128 21 [ [ -LRB- cord-354827-ipg1vwmv 128 22 26 26 CD cord-354827-ipg1vwmv 128 23 ] ] -RRB- cord-354827-ipg1vwmv 128 24 . . . cord-354827-ipg1vwmv 129 1 However however RB cord-354827-ipg1vwmv 129 2 , , , cord-354827-ipg1vwmv 129 3 such such JJ cord-354827-ipg1vwmv 129 4 responses response NNS cord-354827-ipg1vwmv 129 5 appear appear VBP cord-354827-ipg1vwmv 129 6 to to TO cord-354827-ipg1vwmv 129 7 be be VB cord-354827-ipg1vwmv 129 8 variable variable JJ cord-354827-ipg1vwmv 129 9 and and CC cord-354827-ipg1vwmv 129 10 no no DT cord-354827-ipg1vwmv 129 11 obvious obvious JJ cord-354827-ipg1vwmv 129 12 immuno immuno JJ cord-354827-ipg1vwmv 129 13 - - JJ cord-354827-ipg1vwmv 129 14 dominant dominant JJ cord-354827-ipg1vwmv 129 15 antigens antigen NNS cord-354827-ipg1vwmv 129 16 have have VBP cord-354827-ipg1vwmv 129 17 been be VBN cord-354827-ipg1vwmv 129 18 identified identify VBN cord-354827-ipg1vwmv 129 19 . . . cord-354827-ipg1vwmv 130 1 Studies study NNS cord-354827-ipg1vwmv 130 2 may may MD cord-354827-ipg1vwmv 130 3 be be VB cord-354827-ipg1vwmv 130 4 confounded confound VBN cord-354827-ipg1vwmv 130 5 by by IN cord-354827-ipg1vwmv 130 6 the the DT cord-354827-ipg1vwmv 130 7 fact fact NN cord-354827-ipg1vwmv 130 8 that that IN cord-354827-ipg1vwmv 130 9 in in IN cord-354827-ipg1vwmv 130 10 vitro vitro FW cord-354827-ipg1vwmv 130 11 grown grow VBN cord-354827-ipg1vwmv 131 1 S. S. NNP cord-354827-ipg1vwmv 131 2 Typhi Typhi NNP cord-354827-ipg1vwmv 131 3 are be VBP cord-354827-ipg1vwmv 131 4 used use VBN cord-354827-ipg1vwmv 131 5 to to TO cord-354827-ipg1vwmv 131 6 measure measure VB cord-354827-ipg1vwmv 131 7 responses response NNS cord-354827-ipg1vwmv 131 8 , , , cord-354827-ipg1vwmv 131 9 a a DT cord-354827-ipg1vwmv 131 10 factor factor NN cord-354827-ipg1vwmv 131 11 that that WDT cord-354827-ipg1vwmv 131 12 would would MD cord-354827-ipg1vwmv 131 13 eliminate eliminate VB cord-354827-ipg1vwmv 131 14 the the DT cord-354827-ipg1vwmv 131 15 detection detection NN cord-354827-ipg1vwmv 131 16 of of IN cord-354827-ipg1vwmv 131 17 any any DT cord-354827-ipg1vwmv 131 18 antigen antigen NN cord-354827-ipg1vwmv 131 19 exclusively exclusively RB cord-354827-ipg1vwmv 131 20 expressed express VBN cord-354827-ipg1vwmv 131 21 in in IN cord-354827-ipg1vwmv 131 22 the the DT cord-354827-ipg1vwmv 131 23 host host NN cord-354827-ipg1vwmv 131 24 . . . cord-354827-ipg1vwmv 132 1 This this DT cord-354827-ipg1vwmv 132 2 could could MD cord-354827-ipg1vwmv 132 3 be be VB cord-354827-ipg1vwmv 132 4 an an DT cord-354827-ipg1vwmv 132 5 important important JJ cord-354827-ipg1vwmv 132 6 consideration consideration NN cord-354827-ipg1vwmv 132 7 as as IN cord-354827-ipg1vwmv 132 8 many many JJ cord-354827-ipg1vwmv 132 9 surface surface NN cord-354827-ipg1vwmv 132 10 structures structure NNS cord-354827-ipg1vwmv 132 11 , , , cord-354827-ipg1vwmv 132 12 e.g. e.g. IN cord-354827-ipg1vwmv 132 13 pili pili NNP cord-354827-ipg1vwmv 132 14 , , , cord-354827-ipg1vwmv 132 15 have have VBP cord-354827-ipg1vwmv 132 16 such such JJ cord-354827-ipg1vwmv 132 17 properties property NNS cord-354827-ipg1vwmv 132 18 . . . cord-354827-ipg1vwmv 133 1 A a DT cord-354827-ipg1vwmv 133 2 potentially potentially RB cord-354827-ipg1vwmv 133 3 productive productive JJ cord-354827-ipg1vwmv 133 4 area area NN cord-354827-ipg1vwmv 133 5 may may MD cord-354827-ipg1vwmv 133 6 be be VB cord-354827-ipg1vwmv 133 7 to to TO cord-354827-ipg1vwmv 133 8 search search VB cord-354827-ipg1vwmv 133 9 for for IN cord-354827-ipg1vwmv 133 10 novel novel JJ cord-354827-ipg1vwmv 133 11 antigens antigen NNS cord-354827-ipg1vwmv 133 12 which which WDT cord-354827-ipg1vwmv 133 13 are be VBP cord-354827-ipg1vwmv 133 14 specific specific JJ cord-354827-ipg1vwmv 133 15 for for IN cord-354827-ipg1vwmv 133 16 S. S. NNP cord-354827-ipg1vwmv 133 17 Typhi Typhi NNP cord-354827-ipg1vwmv 133 18 . . . cord-354827-ipg1vwmv 134 1 Candidate candidate NN cord-354827-ipg1vwmv 134 2 targets target NNS cord-354827-ipg1vwmv 134 3 could could MD cord-354827-ipg1vwmv 134 4 be be VB cord-354827-ipg1vwmv 134 5 identified identify VBN cord-354827-ipg1vwmv 134 6 initially initially RB cord-354827-ipg1vwmv 134 7 by by IN cord-354827-ipg1vwmv 134 8 bioinformatics bioinformatic NNS cord-354827-ipg1vwmv 134 9 . . . cord-354827-ipg1vwmv 135 1 Novel novel JJ cord-354827-ipg1vwmv 135 2 candidates candidate NNS cord-354827-ipg1vwmv 135 3 could could MD cord-354827-ipg1vwmv 135 4 be be VB cord-354827-ipg1vwmv 135 5 expressed express VBN cord-354827-ipg1vwmv 135 6 in in IN cord-354827-ipg1vwmv 135 7 systems system NNS cord-354827-ipg1vwmv 135 8 such such JJ cord-354827-ipg1vwmv 135 9 as as IN cord-354827-ipg1vwmv 135 10 yeast yeast NN cord-354827-ipg1vwmv 135 11 to to TO cord-354827-ipg1vwmv 135 12 minimize minimize VB cord-354827-ipg1vwmv 135 13 contamination contamination NN cord-354827-ipg1vwmv 135 14 with with IN cord-354827-ipg1vwmv 135 15 cross cross JJ cord-354827-ipg1vwmv 135 16 - - JJ cord-354827-ipg1vwmv 135 17 reactive reactive JJ cord-354827-ipg1vwmv 135 18 antigens antigen NNS cord-354827-ipg1vwmv 135 19 . . . cord-354827-ipg1vwmv 136 1 A a DT cord-354827-ipg1vwmv 136 2 pool pool NN cord-354827-ipg1vwmv 136 3 of of IN cord-354827-ipg1vwmv 136 4 highly highly RB cord-354827-ipg1vwmv 136 5 purified purify VBN cord-354827-ipg1vwmv 136 6 specific specific JJ cord-354827-ipg1vwmv 136 7 antigens antigen NNS cord-354827-ipg1vwmv 136 8 could could MD cord-354827-ipg1vwmv 136 9 be be VB cord-354827-ipg1vwmv 136 10 screened screen VBN cord-354827-ipg1vwmv 136 11 using use VBG cord-354827-ipg1vwmv 136 12 serum serum NN cord-354827-ipg1vwmv 136 13 from from IN cord-354827-ipg1vwmv 136 14 typhoid typhoid NN cord-354827-ipg1vwmv 136 15 patients patient NNS cord-354827-ipg1vwmv 136 16 and and CC cord-354827-ipg1vwmv 136 17 appropriate appropriate JJ cord-354827-ipg1vwmv 136 18 controls control NNS cord-354827-ipg1vwmv 136 19 . . . cord-354827-ipg1vwmv 137 1 Protein protein NN cord-354827-ipg1vwmv 137 2 microarrays microarray NNS cord-354827-ipg1vwmv 137 3 could could MD cord-354827-ipg1vwmv 137 4 be be VB cord-354827-ipg1vwmv 137 5 exploited exploit VBN cord-354827-ipg1vwmv 137 6 in in IN cord-354827-ipg1vwmv 137 7 the the DT cord-354827-ipg1vwmv 137 8 screening screening NN cord-354827-ipg1vwmv 137 9 [ [ -LRB- cord-354827-ipg1vwmv 137 10 42 42 CD cord-354827-ipg1vwmv 137 11 ] ] -RRB- cord-354827-ipg1vwmv 137 12 . . . cord-354827-ipg1vwmv 138 1 Testing test VBG cord-354827-ipg1vwmv 138 2 in in IN cord-354827-ipg1vwmv 138 3 a a DT cord-354827-ipg1vwmv 138 4 cohort cohort NN cord-354827-ipg1vwmv 138 5 of of IN cord-354827-ipg1vwmv 138 6 patients patient NNS cord-354827-ipg1vwmv 138 7 could could MD cord-354827-ipg1vwmv 138 8 reveal reveal VB cord-354827-ipg1vwmv 138 9 specific specific JJ cord-354827-ipg1vwmv 138 10 patterns pattern NNS cord-354827-ipg1vwmv 138 11 or or CC cord-354827-ipg1vwmv 138 12 quantities quantity NNS cord-354827-ipg1vwmv 138 13 of of IN cord-354827-ipg1vwmv 138 14 antibodies antibody NNS cord-354827-ipg1vwmv 138 15 which which WDT cord-354827-ipg1vwmv 138 16 would would MD cord-354827-ipg1vwmv 138 17 be be VB cord-354827-ipg1vwmv 138 18 indicative indicative JJ cord-354827-ipg1vwmv 138 19 of of IN cord-354827-ipg1vwmv 138 20 typhoid typhoid NN cord-354827-ipg1vwmv 138 21 infection infection NN cord-354827-ipg1vwmv 138 22 . . . cord-354827-ipg1vwmv 139 1 Ultimately ultimately RB cord-354827-ipg1vwmv 139 2 , , , cord-354827-ipg1vwmv 139 3 novel novel JJ cord-354827-ipg1vwmv 139 4 antigen(s antigen(s NNP cord-354827-ipg1vwmv 139 5 ) ) -RRB- cord-354827-ipg1vwmv 139 6 could could MD cord-354827-ipg1vwmv 139 7 be be VB cord-354827-ipg1vwmv 139 8 placed place VBN cord-354827-ipg1vwmv 139 9 onto onto IN cord-354827-ipg1vwmv 139 10 membrane membrane NN cord-354827-ipg1vwmv 139 11 to to TO cord-354827-ipg1vwmv 139 12 form form VB cord-354827-ipg1vwmv 139 13 the the DT cord-354827-ipg1vwmv 139 14 basis basis NN cord-354827-ipg1vwmv 139 15 of of IN cord-354827-ipg1vwmv 139 16 a a DT cord-354827-ipg1vwmv 139 17 low low JJ cord-354827-ipg1vwmv 139 18 cost cost NN cord-354827-ipg1vwmv 139 19 rapid rapid JJ cord-354827-ipg1vwmv 139 20 test test NN cord-354827-ipg1vwmv 139 21 . . . cord-354827-ipg1vwmv 140 1 This this DT cord-354827-ipg1vwmv 140 2 is be VBZ cord-354827-ipg1vwmv 140 3 an an DT cord-354827-ipg1vwmv 140 4 open open JJ cord-354827-ipg1vwmv 140 5 and and CC cord-354827-ipg1vwmv 140 6 uninvestigated uninvestigated JJ cord-354827-ipg1vwmv 140 7 area area NN cord-354827-ipg1vwmv 140 8 and and CC cord-354827-ipg1vwmv 140 9 with with IN cord-354827-ipg1vwmv 140 10 a a DT cord-354827-ipg1vwmv 140 11 suitable suitable JJ cord-354827-ipg1vwmv 140 12 assay assay NN cord-354827-ipg1vwmv 140 13 and and CC cord-354827-ipg1vwmv 140 14 patient patient NN cord-354827-ipg1vwmv 140 15 material material NN cord-354827-ipg1vwmv 140 16 , , , cord-354827-ipg1vwmv 140 17 it -PRON- PRP cord-354827-ipg1vwmv 140 18 may may MD cord-354827-ipg1vwmv 140 19 be be VB cord-354827-ipg1vwmv 140 20 one one CD cord-354827-ipg1vwmv 140 21 of of IN cord-354827-ipg1vwmv 140 22 the the DT cord-354827-ipg1vwmv 140 23 most most RBS cord-354827-ipg1vwmv 140 24 straightforward straightforward JJ cord-354827-ipg1vwmv 140 25 ways way NNS cord-354827-ipg1vwmv 140 26 to to TO cord-354827-ipg1vwmv 140 27 initially initially RB cord-354827-ipg1vwmv 140 28 develop develop VB cord-354827-ipg1vwmv 140 29 a a DT cord-354827-ipg1vwmv 140 30 low low JJ cord-354827-ipg1vwmv 140 31 cost cost NN cord-354827-ipg1vwmv 140 32 and and CC cord-354827-ipg1vwmv 140 33 highly highly RB cord-354827-ipg1vwmv 140 34 specific specific JJ cord-354827-ipg1vwmv 140 35 test test NN cord-354827-ipg1vwmv 140 36 . . . cord-354827-ipg1vwmv 141 1 The the DT cord-354827-ipg1vwmv 141 2 detection detection NN cord-354827-ipg1vwmv 141 3 of of IN cord-354827-ipg1vwmv 141 4 specific specific JJ cord-354827-ipg1vwmv 141 5 DNA dna NN cord-354827-ipg1vwmv 141 6 sequences sequence NNS cord-354827-ipg1vwmv 141 7 within within IN cord-354827-ipg1vwmv 141 8 the the DT cord-354827-ipg1vwmv 141 9 genome genome NN cord-354827-ipg1vwmv 141 10 of of IN cord-354827-ipg1vwmv 141 11 S. S. NNP cord-354827-ipg1vwmv 141 12 Typhi Typhi NNP cord-354827-ipg1vwmv 141 13 would would MD cord-354827-ipg1vwmv 141 14 appear appear VB cord-354827-ipg1vwmv 141 15 to to TO cord-354827-ipg1vwmv 141 16 be be VB cord-354827-ipg1vwmv 141 17 an an DT cord-354827-ipg1vwmv 141 18 attractive attractive JJ cord-354827-ipg1vwmv 141 19 proposition proposition NN cord-354827-ipg1vwmv 141 20 . . . cord-354827-ipg1vwmv 142 1 Is be VBZ cord-354827-ipg1vwmv 142 2 a a DT cord-354827-ipg1vwmv 142 3 robust robust JJ cord-354827-ipg1vwmv 142 4 DNA dna NN cord-354827-ipg1vwmv 142 5 - - HYPH cord-354827-ipg1vwmv 142 6 based base VBN cord-354827-ipg1vwmv 142 7 test test NN cord-354827-ipg1vwmv 142 8 a a DT cord-354827-ipg1vwmv 142 9 real real JJ cord-354827-ipg1vwmv 142 10 option option NN cord-354827-ipg1vwmv 142 11 for for IN cord-354827-ipg1vwmv 142 12 routine routine JJ cord-354827-ipg1vwmv 142 13 typhoid typhoid NN cord-354827-ipg1vwmv 142 14 diagnostics diagnostic NNS cord-354827-ipg1vwmv 142 15 ? ? . cord-354827-ipg1vwmv 143 1 Many many JJ cord-354827-ipg1vwmv 143 2 S. S. NNP cord-354827-ipg1vwmv 143 3 Typhi Typhi NNP cord-354827-ipg1vwmv 143 4 PCRbased pcrbase VBN cord-354827-ipg1vwmv 143 5 assays assay NNS cord-354827-ipg1vwmv 143 6 have have VBP cord-354827-ipg1vwmv 143 7 targeted target VBN cord-354827-ipg1vwmv 143 8 the the DT cord-354827-ipg1vwmv 143 9 fliC flic NN cord-354827-ipg1vwmv 143 10 gene gene NN cord-354827-ipg1vwmv 143 11 , , , cord-354827-ipg1vwmv 143 12 utilizing utilize VBG cord-354827-ipg1vwmv 143 13 nested nest VBN cord-354827-ipg1vwmv 143 14 primers primer NNS cord-354827-ipg1vwmv 143 15 to to TO cord-354827-ipg1vwmv 143 16 improve improve VB cord-354827-ipg1vwmv 143 17 sensitivity sensitivity NN cord-354827-ipg1vwmv 143 18 [ [ -LRB- cord-354827-ipg1vwmv 143 19 43 43 CD cord-354827-ipg1vwmv 143 20 ] ] -RRB- cord-354827-ipg1vwmv 143 21 [ [ -LRB- cord-354827-ipg1vwmv 143 22 44 44 CD cord-354827-ipg1vwmv 143 23 ] ] -RRB- cord-354827-ipg1vwmv 143 24 [ [ -LRB- cord-354827-ipg1vwmv 143 25 45 45 CD cord-354827-ipg1vwmv 143 26 ] ] -RRB- cord-354827-ipg1vwmv 144 1 [ [ -LRB- cord-354827-ipg1vwmv 144 2 46 46 CD cord-354827-ipg1vwmv 144 3 ] ] -RRB- cord-354827-ipg1vwmv 144 4 [ [ -LRB- cord-354827-ipg1vwmv 144 5 47 47 CD cord-354827-ipg1vwmv 144 6 ] ] -RRB- cord-354827-ipg1vwmv 144 7 . . . cord-354827-ipg1vwmv 145 1 There there EX cord-354827-ipg1vwmv 145 2 is be VBZ cord-354827-ipg1vwmv 145 3 an an DT cord-354827-ipg1vwmv 145 4 additional additional JJ cord-354827-ipg1vwmv 145 5 sensitivity sensitivity NN cord-354827-ipg1vwmv 145 6 benefit benefit NN cord-354827-ipg1vwmv 145 7 of of IN cord-354827-ipg1vwmv 145 8 PCR PCR NNP cord-354827-ipg1vwmv 145 9 , , , cord-354827-ipg1vwmv 145 10 in in IN cord-354827-ipg1vwmv 145 11 that that IN cord-354827-ipg1vwmv 145 12 it -PRON- PRP cord-354827-ipg1vwmv 145 13 can can MD cord-354827-ipg1vwmv 145 14 theoretically theoretically RB cord-354827-ipg1vwmv 145 15 amplify amplify VB cord-354827-ipg1vwmv 145 16 DNA DNA NNP cord-354827-ipg1vwmv 145 17 from from IN cord-354827-ipg1vwmv 145 18 dead dead JJ cord-354827-ipg1vwmv 145 19 or or CC cord-354827-ipg1vwmv 145 20 unculturable unculturable JJ cord-354827-ipg1vwmv 145 21 bacteria bacteria NNS cord-354827-ipg1vwmv 145 22 . . . cord-354827-ipg1vwmv 146 1 Various various JJ cord-354827-ipg1vwmv 146 2 PCR PCR NNP cord-354827-ipg1vwmv 146 3 - - HYPH cord-354827-ipg1vwmv 146 4 based base VBN cord-354827-ipg1vwmv 146 5 studies study NNS cord-354827-ipg1vwmv 146 6 on on IN cord-354827-ipg1vwmv 146 7 typhoid typhoid NN cord-354827-ipg1vwmv 146 8 suggest suggest VBP cord-354827-ipg1vwmv 146 9 that that IN cord-354827-ipg1vwmv 146 10 the the DT cord-354827-ipg1vwmv 146 11 assay assay NN cord-354827-ipg1vwmv 146 12 is be VBZ cord-354827-ipg1vwmv 146 13 specific specific JJ cord-354827-ipg1vwmv 146 14 and and CC cord-354827-ipg1vwmv 146 15 sensitive sensitive JJ cord-354827-ipg1vwmv 146 16 and and CC cord-354827-ipg1vwmv 146 17 relatively relatively RB cord-354827-ipg1vwmv 146 18 straight straight RB cord-354827-ipg1vwmv 146 19 forward forward RB cord-354827-ipg1vwmv 146 20 to to TO cord-354827-ipg1vwmv 146 21 perform perform VB cord-354827-ipg1vwmv 146 22 . . . cord-354827-ipg1vwmv 147 1 Indeed indeed RB cord-354827-ipg1vwmv 147 2 , , , cord-354827-ipg1vwmv 147 3 such such JJ cord-354827-ipg1vwmv 147 4 studies study NNS cord-354827-ipg1vwmv 147 5 have have VBP cord-354827-ipg1vwmv 147 6 yielded yield VBN cord-354827-ipg1vwmv 147 7 sensitivities sensitivity NNS cord-354827-ipg1vwmv 147 8 > > XX cord-354827-ipg1vwmv 147 9 90 90 CD cord-354827-ipg1vwmv 147 10 % % NN cord-354827-ipg1vwmv 147 11 . . . cord-354827-ipg1vwmv 148 1 However however RB cord-354827-ipg1vwmv 148 2 , , , cord-354827-ipg1vwmv 148 3 we -PRON- PRP cord-354827-ipg1vwmv 148 4 believe believe VBP cord-354827-ipg1vwmv 148 5 PCR PCR NNP cord-354827-ipg1vwmv 148 6 offers offer VBZ cord-354827-ipg1vwmv 148 7 only only RB cord-354827-ipg1vwmv 148 8 limited limited JJ cord-354827-ipg1vwmv 148 9 potential potential NN cord-354827-ipg1vwmv 148 10 for for IN cord-354827-ipg1vwmv 148 11 typhoid typhoid NN cord-354827-ipg1vwmv 148 12 diagnostics diagnostic NNS cord-354827-ipg1vwmv 148 13 . . . cord-354827-ipg1vwmv 149 1 Currently currently RB cord-354827-ipg1vwmv 149 2 there there EX cord-354827-ipg1vwmv 149 3 is be VBZ cord-354827-ipg1vwmv 149 4 no no DT cord-354827-ipg1vwmv 149 5 validated validate VBN cord-354827-ipg1vwmv 149 6 PCR PCR NNP cord-354827-ipg1vwmv 149 7 test test NN cord-354827-ipg1vwmv 149 8 in in IN cord-354827-ipg1vwmv 149 9 common common JJ cord-354827-ipg1vwmv 149 10 use use NN cord-354827-ipg1vwmv 149 11 , , , cord-354827-ipg1vwmv 149 12 only only RB cord-354827-ipg1vwmv 149 13 in in IN cord-354827-ipg1vwmv 149 14 - - HYPH cord-354827-ipg1vwmv 149 15 house house NN cord-354827-ipg1vwmv 149 16 systems system NNS cord-354827-ipg1vwmv 149 17 which which WDT cord-354827-ipg1vwmv 149 18 are be VBP cord-354827-ipg1vwmv 149 19 open open JJ cord-354827-ipg1vwmv 149 20 to to IN cord-354827-ipg1vwmv 149 21 differing differ VBG cord-354827-ipg1vwmv 149 22 interpretation interpretation NN cord-354827-ipg1vwmv 149 23 and and CC cord-354827-ipg1vwmv 149 24 none none NN cord-354827-ipg1vwmv 149 25 would would MD cord-354827-ipg1vwmv 149 26 meet meet VB cord-354827-ipg1vwmv 149 27 the the DT cord-354827-ipg1vwmv 149 28 rigors rigor NNS cord-354827-ipg1vwmv 149 29 of of IN cord-354827-ipg1vwmv 149 30 quality quality NN cord-354827-ipg1vwmv 149 31 control control NN cord-354827-ipg1vwmv 149 32 to to TO cord-354827-ipg1vwmv 149 33 make make VB cord-354827-ipg1vwmv 149 34 this this DT cord-354827-ipg1vwmv 149 35 assay assay NN cord-354827-ipg1vwmv 149 36 used use VBN cord-354827-ipg1vwmv 149 37 worldwide worldwide RB cord-354827-ipg1vwmv 149 38 . . . cord-354827-ipg1vwmv 150 1 Massi Massi NNP cord-354827-ipg1vwmv 150 2 et et NNP cord-354827-ipg1vwmv 150 3 al al NNP cord-354827-ipg1vwmv 150 4 . . . cord-354827-ipg1vwmv 150 5 utilized utilize VBN cord-354827-ipg1vwmv 150 6 a a DT cord-354827-ipg1vwmv 150 7 real real JJ cord-354827-ipg1vwmv 150 8 - - HYPH cord-354827-ipg1vwmv 150 9 time time NN cord-354827-ipg1vwmv 150 10 system system NN cord-354827-ipg1vwmv 150 11 based base VBN cord-354827-ipg1vwmv 150 12 on on IN cord-354827-ipg1vwmv 150 13 fliC flic PRP cord-354827-ipg1vwmv 150 14 to to TO cord-354827-ipg1vwmv 150 15 detect detect VB cord-354827-ipg1vwmv 150 16 S. S. NNP cord-354827-ipg1vwmv 150 17 Typhi Typhi NNP cord-354827-ipg1vwmv 150 18 in in IN cord-354827-ipg1vwmv 150 19 patients patient NNS cord-354827-ipg1vwmv 150 20 with with IN cord-354827-ipg1vwmv 150 21 clinically clinically RB cord-354827-ipg1vwmv 150 22 diagnosed diagnose VBN cord-354827-ipg1vwmv 150 23 typhoid typhoid NN cord-354827-ipg1vwmv 150 24 [ [ -LRB- cord-354827-ipg1vwmv 150 25 48 48 CD cord-354827-ipg1vwmv 150 26 ] ] -RRB- cord-354827-ipg1vwmv 150 27 . . . cord-354827-ipg1vwmv 151 1 They -PRON- PRP cord-354827-ipg1vwmv 151 2 were be VBD cord-354827-ipg1vwmv 151 3 able able JJ cord-354827-ipg1vwmv 151 4 to to TO cord-354827-ipg1vwmv 151 5 amplify amplify VB cord-354827-ipg1vwmv 151 6 fliC flic NN cord-354827-ipg1vwmv 151 7 from from IN cord-354827-ipg1vwmv 151 8 all all DT cord-354827-ipg1vwmv 151 9 culture culture NN cord-354827-ipg1vwmv 151 10 - - HYPH cord-354827-ipg1vwmv 151 11 positive positive JJ cord-354827-ipg1vwmv 151 12 and and CC cord-354827-ipg1vwmv 151 13 negative negative JJ cord-354827-ipg1vwmv 151 14 blood blood NN cord-354827-ipg1vwmv 151 15 samples sample NNS cord-354827-ipg1vwmv 151 16 tested test VBN cord-354827-ipg1vwmv 151 17 but but CC cord-354827-ipg1vwmv 151 18 reported report VBD cord-354827-ipg1vwmv 151 19 a a DT cord-354827-ipg1vwmv 151 20 higher high JJR cord-354827-ipg1vwmv 151 21 gene gene NN cord-354827-ipg1vwmv 151 22 copy copy NN cord-354827-ipg1vwmv 151 23 number number NN cord-354827-ipg1vwmv 151 24 in in IN cord-354827-ipg1vwmv 151 25 culture culture NN cord-354827-ipg1vwmv 151 26 positives positive NNS cord-354827-ipg1vwmv 151 27 ( ( -LRB- cord-354827-ipg1vwmv 151 28 1,000 1,000 CD cord-354827-ipg1vwmv 151 29 -45,000 -45,000 NNP cord-354827-ipg1vwmv 151 30 ) ) -RRB- cord-354827-ipg1vwmv 151 31 , , , cord-354827-ipg1vwmv 151 32 compared compare VBN cord-354827-ipg1vwmv 151 33 to to IN cord-354827-ipg1vwmv 151 34 negatives negative NNS cord-354827-ipg1vwmv 151 35 ( ( -LRB- cord-354827-ipg1vwmv 151 36 < < NNP cord-354827-ipg1vwmv 151 37 1000 1000 CD cord-354827-ipg1vwmv 151 38 ) ) -RRB- cord-354827-ipg1vwmv 151 39 . . . cord-354827-ipg1vwmv 152 1 However however RB cord-354827-ipg1vwmv 152 2 , , , cord-354827-ipg1vwmv 152 3 this this DT cord-354827-ipg1vwmv 152 4 real real JJ cord-354827-ipg1vwmv 152 5 - - HYPH cord-354827-ipg1vwmv 152 6 time time NN cord-354827-ipg1vwmv 152 7 PCR PCR NNP cord-354827-ipg1vwmv 152 8 data datum NNS cord-354827-ipg1vwmv 152 9 is be VBZ cord-354827-ipg1vwmv 152 10 somewhat somewhat RB cord-354827-ipg1vwmv 152 11 contradictory contradictory JJ cord-354827-ipg1vwmv 152 12 with with IN cord-354827-ipg1vwmv 152 13 the the DT cord-354827-ipg1vwmv 152 14 microbiological microbiological JJ cord-354827-ipg1vwmv 152 15 data datum NNS cord-354827-ipg1vwmv 152 16 , , , cord-354827-ipg1vwmv 152 17 which which WDT cord-354827-ipg1vwmv 152 18 demonstrates demonstrate VBZ cord-354827-ipg1vwmv 152 19 that that IN cord-354827-ipg1vwmv 152 20 bacteria bacteria NNS cord-354827-ipg1vwmv 152 21 / / SYM cord-354827-ipg1vwmv 152 22 ml ml NNS cord-354827-ipg1vwmv 152 23 of of IN cord-354827-ipg1vwmv 152 24 blood blood NN cord-354827-ipg1vwmv 152 25 is be VBZ cord-354827-ipg1vwmv 152 26 generally generally RB cord-354827-ipg1vwmv 152 27 low low JJ cord-354827-ipg1vwmv 152 28 with with IN cord-354827-ipg1vwmv 152 29 the the DT cord-354827-ipg1vwmv 152 30 majority majority NN cord-354827-ipg1vwmv 152 31 of of IN cord-354827-ipg1vwmv 152 32 patients patient NNS cord-354827-ipg1vwmv 152 33 having have VBG cord-354827-ipg1vwmv 152 34 < < XX cord-354827-ipg1vwmv 152 35 1 1 CD cord-354827-ipg1vwmv 152 36 organism organism NN cord-354827-ipg1vwmv 152 37 / / SYM cord-354827-ipg1vwmv 152 38 ml ml NNS cord-354827-ipg1vwmv 152 39 of of IN cord-354827-ipg1vwmv 152 40 blood blood NN cord-354827-ipg1vwmv 153 1 [ [ -LRB- cord-354827-ipg1vwmv 153 2 21 21 CD cord-354827-ipg1vwmv 153 3 ] ] -RRB- cord-354827-ipg1vwmv 153 4 . . . cord-354827-ipg1vwmv 154 1 It -PRON- PRP cord-354827-ipg1vwmv 154 2 is be VBZ cord-354827-ipg1vwmv 154 3 somewhat somewhat RB cord-354827-ipg1vwmv 154 4 surprising surprising JJ cord-354827-ipg1vwmv 154 5 that that IN cord-354827-ipg1vwmv 154 6 typhoid typhoid NN cord-354827-ipg1vwmv 154 7 patients patient NNS cord-354827-ipg1vwmv 154 8 may may MD cord-354827-ipg1vwmv 154 9 have have VB cord-354827-ipg1vwmv 154 10 between between IN cord-354827-ipg1vwmv 154 11 a a DT cord-354827-ipg1vwmv 154 12 1,000 1,000 CD cord-354827-ipg1vwmv 154 13 to to TO cord-354827-ipg1vwmv 154 14 45,000 45,000 CD cord-354827-ipg1vwmv 154 15 times time NNS cord-354827-ipg1vwmv 154 16 more more JJR cord-354827-ipg1vwmv 154 17 dead dead JJ cord-354827-ipg1vwmv 154 18 bacteria bacteria NNS cord-354827-ipg1vwmv 154 19 than than IN cord-354827-ipg1vwmv 154 20 live live JJ cord-354827-ipg1vwmv 154 21 bacteria bacteria NNS cord-354827-ipg1vwmv 154 22 in in IN cord-354827-ipg1vwmv 154 23 the the DT cord-354827-ipg1vwmv 154 24 blood blood NN cord-354827-ipg1vwmv 154 25 . . . cord-354827-ipg1vwmv 155 1 We -PRON- PRP cord-354827-ipg1vwmv 155 2 recently recently RB cord-354827-ipg1vwmv 155 3 found find VBD cord-354827-ipg1vwmv 155 4 disappointingly disappointingly RB cord-354827-ipg1vwmv 155 5 poor poor JJ cord-354827-ipg1vwmv 155 6 PCR pcr NN cord-354827-ipg1vwmv 155 7 sensitivity sensitivity NN cord-354827-ipg1vwmv 155 8 using use VBG cord-354827-ipg1vwmv 155 9 a a DT cord-354827-ipg1vwmv 155 10 three three CD cord-354827-ipg1vwmv 155 11 color color NN cord-354827-ipg1vwmv 155 12 real real JJ cord-354827-ipg1vwmv 155 13 - - HYPH cord-354827-ipg1vwmv 155 14 time time NN cord-354827-ipg1vwmv 155 15 PCR pcr NN cord-354827-ipg1vwmv 155 16 assay assay NN cord-354827-ipg1vwmv 155 17 that that WDT cord-354827-ipg1vwmv 155 18 was be VBD cord-354827-ipg1vwmv 155 19 capable capable JJ cord-354827-ipg1vwmv 155 20 of of IN cord-354827-ipg1vwmv 155 21 detecting detect VBG cord-354827-ipg1vwmv 155 22 S. S. NNP cord-354827-ipg1vwmv 155 23 Typhi Typhi NNP cord-354827-ipg1vwmv 155 24 , , , cord-354827-ipg1vwmv 155 25 S. S. NNP cord-354827-ipg1vwmv 155 26 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 155 27 A A NNP cord-354827-ipg1vwmv 155 28 and and CC cord-354827-ipg1vwmv 155 29 an an DT cord-354827-ipg1vwmv 155 30 incorporated incorporate VBN cord-354827-ipg1vwmv 155 31 internal internal JJ cord-354827-ipg1vwmv 155 32 control control NN cord-354827-ipg1vwmv 155 33 [ [ -LRB- cord-354827-ipg1vwmv 155 34 49 49 CD cord-354827-ipg1vwmv 155 35 ] ] -RRB- cord-354827-ipg1vwmv 155 36 . . . cord-354827-ipg1vwmv 156 1 When when WRB cord-354827-ipg1vwmv 156 2 tested test VBN cord-354827-ipg1vwmv 156 3 on on IN cord-354827-ipg1vwmv 156 4 spiked spiked JJ cord-354827-ipg1vwmv 156 5 and and CC cord-354827-ipg1vwmv 156 6 control control NN cord-354827-ipg1vwmv 156 7 samples sample NNS cord-354827-ipg1vwmv 156 8 the the DT cord-354827-ipg1vwmv 156 9 assay assay NN cord-354827-ipg1vwmv 156 10 demonstrated demonstrate VBD cord-354827-ipg1vwmv 156 11 high high JJ cord-354827-ipg1vwmv 156 12 specificity specificity NN cord-354827-ipg1vwmv 156 13 and and CC cord-354827-ipg1vwmv 156 14 sensitivity sensitivity NN cord-354827-ipg1vwmv 156 15 . . . cord-354827-ipg1vwmv 157 1 However however RB cord-354827-ipg1vwmv 157 2 , , , cord-354827-ipg1vwmv 157 3 when when WRB cord-354827-ipg1vwmv 157 4 tested test VBN cord-354827-ipg1vwmv 157 5 on on IN cord-354827-ipg1vwmv 157 6 DNA DNA NNP cord-354827-ipg1vwmv 157 7 extracted extract VBN cord-354827-ipg1vwmv 157 8 from from IN cord-354827-ipg1vwmv 157 9 2 2 CD cord-354827-ipg1vwmv 157 10 ml ml NNS cord-354827-ipg1vwmv 157 11 of of IN cord-354827-ipg1vwmv 157 12 blood blood NN cord-354827-ipg1vwmv 157 13 taken take VBN cord-354827-ipg1vwmv 157 14 from from IN cord-354827-ipg1vwmv 157 15 100 100 CD cord-354827-ipg1vwmv 157 16 culture culture NN cord-354827-ipg1vwmv 157 17 confirmed confirm VBD cord-354827-ipg1vwmv 157 18 typhoid typhoid NN cord-354827-ipg1vwmv 157 19 patients patient NNS cord-354827-ipg1vwmv 157 20 the the DT cord-354827-ipg1vwmv 157 21 sensitivity sensitivity NN cord-354827-ipg1vwmv 157 22 rate rate NN cord-354827-ipg1vwmv 157 23 was be VBD cord-354827-ipg1vwmv 157 24 less less JJR cord-354827-ipg1vwmv 157 25 that that IN cord-354827-ipg1vwmv 157 26 50 50 CD cord-354827-ipg1vwmv 157 27 % % NN cord-354827-ipg1vwmv 157 28 . . . cord-354827-ipg1vwmv 158 1 Thus thus RB cord-354827-ipg1vwmv 158 2 confirming confirm VBG cord-354827-ipg1vwmv 158 3 that that IN cord-354827-ipg1vwmv 158 4 PCR PCR NNP cord-354827-ipg1vwmv 158 5 results result NNS cord-354827-ipg1vwmv 158 6 are be VBP cord-354827-ipg1vwmv 158 7 related relate VBN cord-354827-ipg1vwmv 158 8 to to IN cord-354827-ipg1vwmv 158 9 the the DT cord-354827-ipg1vwmv 158 10 actual actual JJ cord-354827-ipg1vwmv 158 11 colony colony NN cord-354827-ipg1vwmv 158 12 forming form VBG cord-354827-ipg1vwmv 158 13 units unit NNS cord-354827-ipg1vwmv 158 14 found find VBN cord-354827-ipg1vwmv 158 15 in in IN cord-354827-ipg1vwmv 158 16 the the DT cord-354827-ipg1vwmv 158 17 blood blood NN cord-354827-ipg1vwmv 158 18 . . . cord-354827-ipg1vwmv 159 1 The the DT cord-354827-ipg1vwmv 159 2 assay assay NN cord-354827-ipg1vwmv 159 3 did do VBD cord-354827-ipg1vwmv 159 4 , , , cord-354827-ipg1vwmv 159 5 however however RB cord-354827-ipg1vwmv 159 6 , , , cord-354827-ipg1vwmv 159 7 demonstrate demonstrate VBP cord-354827-ipg1vwmv 159 8 100 100 CD cord-354827-ipg1vwmv 159 9 % % NN cord-354827-ipg1vwmv 159 10 sensitivity sensitivity NN cord-354827-ipg1vwmv 159 11 on on IN cord-354827-ipg1vwmv 159 12 culture culture NN cord-354827-ipg1vwmv 159 13 positive positive JJ cord-354827-ipg1vwmv 159 14 bone bone NN cord-354827-ipg1vwmv 159 15 marrow marrow NN cord-354827-ipg1vwmv 159 16 samples sample NNS cord-354827-ipg1vwmv 159 17 , , , cord-354827-ipg1vwmv 159 18 which which WDT cord-354827-ipg1vwmv 159 19 are be VBP cord-354827-ipg1vwmv 159 20 known know VBN cord-354827-ipg1vwmv 159 21 to to TO cord-354827-ipg1vwmv 159 22 harbor harbor VB cord-354827-ipg1vwmv 159 23 significantly significantly RB cord-354827-ipg1vwmv 159 24 more more JJR cord-354827-ipg1vwmv 159 25 bacteria bacteria NNS cord-354827-ipg1vwmv 159 26 [ [ -LRB- cord-354827-ipg1vwmv 159 27 22 22 CD cord-354827-ipg1vwmv 159 28 ] ] -RRB- cord-354827-ipg1vwmv 159 29 . . . cord-354827-ipg1vwmv 160 1 For for IN cord-354827-ipg1vwmv 160 2 these these DT cord-354827-ipg1vwmv 160 3 reasons reason NNS cord-354827-ipg1vwmv 160 4 we -PRON- PRP cord-354827-ipg1vwmv 160 5 believe believe VBP cord-354827-ipg1vwmv 160 6 that that IN cord-354827-ipg1vwmv 160 7 DNA dna NN cord-354827-ipg1vwmv 160 8 amplification amplification NN cord-354827-ipg1vwmv 160 9 may may MD cord-354827-ipg1vwmv 160 10 not not RB cord-354827-ipg1vwmv 160 11 be be VB cord-354827-ipg1vwmv 160 12 an an DT cord-354827-ipg1vwmv 160 13 easy easy JJ cord-354827-ipg1vwmv 160 14 route route NN cord-354827-ipg1vwmv 160 15 towards towards IN cord-354827-ipg1vwmv 160 16 developing develop VBG cord-354827-ipg1vwmv 160 17 a a DT cord-354827-ipg1vwmv 160 18 robust robust JJ cord-354827-ipg1vwmv 160 19 diagnostic diagnostic JJ cord-354827-ipg1vwmv 160 20 . . . cord-354827-ipg1vwmv 161 1 Collecting collect VBG cord-354827-ipg1vwmv 161 2 and and CC cord-354827-ipg1vwmv 161 3 then then RB cord-354827-ipg1vwmv 161 4 extracting extract VBG cord-354827-ipg1vwmv 161 5 DNA dna NN cord-354827-ipg1vwmv 161 6 from from IN cord-354827-ipg1vwmv 161 7 a a DT cord-354827-ipg1vwmv 161 8 large large JJ cord-354827-ipg1vwmv 161 9 volume volume NN cord-354827-ipg1vwmv 161 10 of of IN cord-354827-ipg1vwmv 161 11 blood blood NN cord-354827-ipg1vwmv 161 12 is be VBZ cord-354827-ipg1vwmv 161 13 not not RB cord-354827-ipg1vwmv 161 14 a a DT cord-354827-ipg1vwmv 161 15 straightforward straightforward JJ cord-354827-ipg1vwmv 161 16 option option NN cord-354827-ipg1vwmv 161 17 , , , cord-354827-ipg1vwmv 161 18 due due IN cord-354827-ipg1vwmv 161 19 to to IN cord-354827-ipg1vwmv 161 20 large large JJ cord-354827-ipg1vwmv 161 21 concentrations concentration NNS cord-354827-ipg1vwmv 161 22 of of IN cord-354827-ipg1vwmv 161 23 human human JJ cord-354827-ipg1vwmv 161 24 DNA dna NN cord-354827-ipg1vwmv 161 25 . . . cord-354827-ipg1vwmv 162 1 Analyzing analyze VBG cord-354827-ipg1vwmv 162 2 stool stool NN cord-354827-ipg1vwmv 162 3 or or CC cord-354827-ipg1vwmv 162 4 urine urine NN cord-354827-ipg1vwmv 162 5 samples sample NNS cord-354827-ipg1vwmv 162 6 may may MD cord-354827-ipg1vwmv 162 7 be be VB cord-354827-ipg1vwmv 162 8 an an DT cord-354827-ipg1vwmv 162 9 alternative alternative JJ cord-354827-ipg1vwmv 162 10 approach approach NN cord-354827-ipg1vwmv 162 11 . . . cord-354827-ipg1vwmv 163 1 A a DT cord-354827-ipg1vwmv 163 2 DNA dna NN cord-354827-ipg1vwmv 163 3 or or CC cord-354827-ipg1vwmv 163 4 bacterial bacterial JJ cord-354827-ipg1vwmv 163 5 capture capture NN cord-354827-ipg1vwmv 163 6 system system NN cord-354827-ipg1vwmv 163 7 or or CC cord-354827-ipg1vwmv 163 8 even even RB cord-354827-ipg1vwmv 163 9 a a DT cord-354827-ipg1vwmv 163 10 culture culture NN cord-354827-ipg1vwmv 163 11 enrichment enrichment NN cord-354827-ipg1vwmv 163 12 step step NN cord-354827-ipg1vwmv 163 13 prior prior RB cord-354827-ipg1vwmv 163 14 to to IN cord-354827-ipg1vwmv 163 15 amplification amplification NN cord-354827-ipg1vwmv 163 16 may may MD cord-354827-ipg1vwmv 163 17 improve improve VB cord-354827-ipg1vwmv 163 18 molecular molecular JJ cord-354827-ipg1vwmv 163 19 sensitivity sensitivity NN cord-354827-ipg1vwmv 163 20 . . . cord-354827-ipg1vwmv 164 1 However however RB cord-354827-ipg1vwmv 164 2 , , , cord-354827-ipg1vwmv 164 3 molecular molecular JJ cord-354827-ipg1vwmv 164 4 diagnostics diagnostic NNS cord-354827-ipg1vwmv 164 5 are be VBP cord-354827-ipg1vwmv 164 6 not not RB cord-354827-ipg1vwmv 164 7 a a DT cord-354827-ipg1vwmv 164 8 cost cost NN cord-354827-ipg1vwmv 164 9 effective effective JJ cord-354827-ipg1vwmv 164 10 or or CC cord-354827-ipg1vwmv 164 11 a a DT cord-354827-ipg1vwmv 164 12 straightforward straightforward NN cord-354827-ipg1vwmv 164 13 to to TO cord-354827-ipg1vwmv 164 14 perform perform VB cord-354827-ipg1vwmv 164 15 as as IN cord-354827-ipg1vwmv 164 16 other other JJ cord-354827-ipg1vwmv 164 17 methods method NNS cord-354827-ipg1vwmv 164 18 , , , cord-354827-ipg1vwmv 164 19 not not RB cord-354827-ipg1vwmv 164 20 every every DT cord-354827-ipg1vwmv 164 21 diagnostic diagnostic JJ cord-354827-ipg1vwmv 164 22 laboratory laboratory NN cord-354827-ipg1vwmv 164 23 in in IN cord-354827-ipg1vwmv 164 24 an an DT cord-354827-ipg1vwmv 164 25 endemic endemic JJ cord-354827-ipg1vwmv 164 26 setting setting NN cord-354827-ipg1vwmv 164 27 would would MD cord-354827-ipg1vwmv 164 28 be be VB cord-354827-ipg1vwmv 164 29 able able JJ cord-354827-ipg1vwmv 164 30 to to TO cord-354827-ipg1vwmv 164 31 perform perform VB cord-354827-ipg1vwmv 164 32 such such PDT cord-354827-ipg1vwmv 164 33 an an DT cord-354827-ipg1vwmv 164 34 assay assay NN cord-354827-ipg1vwmv 164 35 . . . cord-354827-ipg1vwmv 165 1 However however RB cord-354827-ipg1vwmv 165 2 , , , cord-354827-ipg1vwmv 165 3 if if IN cord-354827-ipg1vwmv 165 4 simplified simplified JJ cord-354827-ipg1vwmv 165 5 and and CC cord-354827-ipg1vwmv 165 6 new new JJ cord-354827-ipg1vwmv 165 7 technology technology NN cord-354827-ipg1vwmv 165 8 is be VBZ cord-354827-ipg1vwmv 165 9 applied apply VBN cord-354827-ipg1vwmv 165 10 it -PRON- PRP cord-354827-ipg1vwmv 165 11 an an DT cord-354827-ipg1vwmv 165 12 area area NN cord-354827-ipg1vwmv 165 13 that that WDT cord-354827-ipg1vwmv 165 14 warrants warrant VBZ cord-354827-ipg1vwmv 165 15 further further JJ cord-354827-ipg1vwmv 165 16 independent independent JJ cord-354827-ipg1vwmv 165 17 studies study NNS cord-354827-ipg1vwmv 165 18 . . . cord-354827-ipg1vwmv 166 1 Is be VBZ cord-354827-ipg1vwmv 166 2 it -PRON- PRP cord-354827-ipg1vwmv 166 3 possible possible JJ cord-354827-ipg1vwmv 166 4 to to TO cord-354827-ipg1vwmv 166 5 identify identify VB cord-354827-ipg1vwmv 166 6 host host NN cord-354827-ipg1vwmv 166 7 specific specific JJ cord-354827-ipg1vwmv 166 8 responses response NNS cord-354827-ipg1vwmv 166 9 to to IN cord-354827-ipg1vwmv 166 10 typhoid typhoid NN cord-354827-ipg1vwmv 166 11 that that WDT cord-354827-ipg1vwmv 166 12 are be VBP cord-354827-ipg1vwmv 166 13 distinct distinct JJ cord-354827-ipg1vwmv 166 14 from from IN cord-354827-ipg1vwmv 166 15 other other JJ cord-354827-ipg1vwmv 166 16 febrile febrile JJ cord-354827-ipg1vwmv 166 17 diseases disease NNS cord-354827-ipg1vwmv 166 18 such such JJ cord-354827-ipg1vwmv 166 19 as as IN cord-354827-ipg1vwmv 166 20 malaria malaria NN cord-354827-ipg1vwmv 166 21 or or CC cord-354827-ipg1vwmv 166 22 dengue dengue NN cord-354827-ipg1vwmv 166 23 ? ? . cord-354827-ipg1vwmv 167 1 If if IN cord-354827-ipg1vwmv 167 2 so so RB cord-354827-ipg1vwmv 167 3 , , , cord-354827-ipg1vwmv 167 4 what what WP cord-354827-ipg1vwmv 167 5 sort sort NN cord-354827-ipg1vwmv 167 6 of of IN cord-354827-ipg1vwmv 167 7 responses response NNS cord-354827-ipg1vwmv 167 8 should should MD cord-354827-ipg1vwmv 167 9 we -PRON- PRP cord-354827-ipg1vwmv 167 10 look look VB cord-354827-ipg1vwmv 167 11 for for IN cord-354827-ipg1vwmv 167 12 ? ? . cord-354827-ipg1vwmv 168 1 Typhoid typhoid NN cord-354827-ipg1vwmv 168 2 patients patient NNS cord-354827-ipg1vwmv 168 3 display display VBP cord-354827-ipg1vwmv 168 4 a a DT cord-354827-ipg1vwmv 168 5 number number NN cord-354827-ipg1vwmv 168 6 of of IN cord-354827-ipg1vwmv 168 7 symptoms symptom NNS cord-354827-ipg1vwmv 168 8 including include VBG cord-354827-ipg1vwmv 168 9 fever fever NN cord-354827-ipg1vwmv 168 10 and and CC cord-354827-ipg1vwmv 168 11 mount mount VB cord-354827-ipg1vwmv 168 12 a a DT cord-354827-ipg1vwmv 168 13 number number NN cord-354827-ipg1vwmv 168 14 of of IN cord-354827-ipg1vwmv 168 15 immune immune JJ cord-354827-ipg1vwmv 168 16 and and CC cord-354827-ipg1vwmv 168 17 physiological physiological JJ cord-354827-ipg1vwmv 168 18 responses response NNS cord-354827-ipg1vwmv 168 19 . . . cord-354827-ipg1vwmv 169 1 Such such JJ cord-354827-ipg1vwmv 169 2 responses response NNS cord-354827-ipg1vwmv 169 3 can can MD cord-354827-ipg1vwmv 169 4 be be VB cord-354827-ipg1vwmv 169 5 examined examine VBN cord-354827-ipg1vwmv 169 6 by by IN cord-354827-ipg1vwmv 169 7 simple simple JJ cord-354827-ipg1vwmv 169 8 stimulation stimulation NN cord-354827-ipg1vwmv 169 9 assays assay NNS cord-354827-ipg1vwmv 169 10 , , , cord-354827-ipg1vwmv 169 11 exploiting exploit VBG cord-354827-ipg1vwmv 169 12 whole whole JJ cord-354827-ipg1vwmv 169 13 blood blood NN cord-354827-ipg1vwmv 169 14 , , , cord-354827-ipg1vwmv 169 15 cell cell NN cord-354827-ipg1vwmv 169 16 fractions fraction NNS cord-354827-ipg1vwmv 169 17 or or CC cord-354827-ipg1vwmv 169 18 serum serum NN cord-354827-ipg1vwmv 169 19 . . . cord-354827-ipg1vwmv 170 1 Currently currently RB cord-354827-ipg1vwmv 170 2 , , , cord-354827-ipg1vwmv 170 3 there there EX cord-354827-ipg1vwmv 170 4 has have VBZ cord-354827-ipg1vwmv 170 5 been be VBN cord-354827-ipg1vwmv 170 6 no no DT cord-354827-ipg1vwmv 170 7 precise precise JJ cord-354827-ipg1vwmv 170 8 correlate correlate NN cord-354827-ipg1vwmv 170 9 of of IN cord-354827-ipg1vwmv 170 10 infection infection NN cord-354827-ipg1vwmv 170 11 or or CC cord-354827-ipg1vwmv 170 12 biomarker biomarker NN cord-354827-ipg1vwmv 170 13 for for IN cord-354827-ipg1vwmv 170 14 typhoid typhoid NN cord-354827-ipg1vwmv 170 15 identified identify VBN cord-354827-ipg1vwmv 170 16 . . . cord-354827-ipg1vwmv 171 1 An an DT cord-354827-ipg1vwmv 171 2 expansive expansive JJ cord-354827-ipg1vwmv 171 3 , , , cord-354827-ipg1vwmv 171 4 yet yet CC cord-354827-ipg1vwmv 171 5 costly costly JJ cord-354827-ipg1vwmv 171 6 option option NN cord-354827-ipg1vwmv 171 7 would would MD cord-354827-ipg1vwmv 171 8 be be VB cord-354827-ipg1vwmv 171 9 to to TO cord-354827-ipg1vwmv 171 10 take take VB cord-354827-ipg1vwmv 171 11 an an DT cord-354827-ipg1vwmv 171 12 approach approach NN cord-354827-ipg1vwmv 171 13 based base VBN cord-354827-ipg1vwmv 171 14 on on IN cord-354827-ipg1vwmv 171 15 human human JJ cord-354827-ipg1vwmv 171 16 microarrays microarray NNS cord-354827-ipg1vwmv 171 17 [ [ -LRB- cord-354827-ipg1vwmv 171 18 50 50 CD cord-354827-ipg1vwmv 171 19 ] ] -RRB- cord-354827-ipg1vwmv 171 20 . . . cord-354827-ipg1vwmv 172 1 Transcriptional transcriptional JJ cord-354827-ipg1vwmv 172 2 analysis analysis NN cord-354827-ipg1vwmv 172 3 of of IN cord-354827-ipg1vwmv 172 4 RNA RNA NNP cord-354827-ipg1vwmv 172 5 extracted extract VBN cord-354827-ipg1vwmv 172 6 from from IN cord-354827-ipg1vwmv 172 7 the the DT cord-354827-ipg1vwmv 172 8 blood blood NN cord-354827-ipg1vwmv 172 9 of of IN cord-354827-ipg1vwmv 172 10 typhoid typhoid NN cord-354827-ipg1vwmv 172 11 patients patient NNS cord-354827-ipg1vwmv 172 12 could could MD cord-354827-ipg1vwmv 172 13 be be VB cord-354827-ipg1vwmv 172 14 performed perform VBN cord-354827-ipg1vwmv 172 15 to to TO cord-354827-ipg1vwmv 172 16 identify identify VB cord-354827-ipg1vwmv 172 17 specific specific JJ cord-354827-ipg1vwmv 172 18 genes gene NNS cord-354827-ipg1vwmv 172 19 , , , cord-354827-ipg1vwmv 172 20 pathways pathway NNS cord-354827-ipg1vwmv 172 21 , , , cord-354827-ipg1vwmv 172 22 interactions interaction NNS cord-354827-ipg1vwmv 172 23 or or CC cord-354827-ipg1vwmv 172 24 transcriptional transcriptional JJ cord-354827-ipg1vwmv 172 25 regulatory regulatory JJ cord-354827-ipg1vwmv 172 26 hubs hub NNS cord-354827-ipg1vwmv 172 27 that that WDT cord-354827-ipg1vwmv 172 28 are be VBP cord-354827-ipg1vwmv 172 29 activated activate VBN cord-354827-ipg1vwmv 172 30 in in IN cord-354827-ipg1vwmv 172 31 the the DT cord-354827-ipg1vwmv 172 32 host host NN cord-354827-ipg1vwmv 172 33 during during IN cord-354827-ipg1vwmv 172 34 infection infection NN cord-354827-ipg1vwmv 172 35 . . . cord-354827-ipg1vwmv 173 1 Microarray Microarray NNP cord-354827-ipg1vwmv 173 2 data datum NNS cord-354827-ipg1vwmv 173 3 is be VBZ cord-354827-ipg1vwmv 173 4 often often RB cord-354827-ipg1vwmv 173 5 publicly publicly RB cord-354827-ipg1vwmv 173 6 available available JJ cord-354827-ipg1vwmv 173 7 and and CC cord-354827-ipg1vwmv 173 8 comparative comparative JJ cord-354827-ipg1vwmv 173 9 analysis analysis NN cord-354827-ipg1vwmv 173 10 with with IN cord-354827-ipg1vwmv 173 11 the the DT cord-354827-ipg1vwmv 173 12 transcriptional transcriptional JJ cord-354827-ipg1vwmv 173 13 profile profile NN cord-354827-ipg1vwmv 173 14 from from IN cord-354827-ipg1vwmv 173 15 patients patient NNS cord-354827-ipg1vwmv 173 16 with with IN cord-354827-ipg1vwmv 173 17 other other JJ cord-354827-ipg1vwmv 173 18 diseases disease NNS cord-354827-ipg1vwmv 173 19 could could MD cord-354827-ipg1vwmv 173 20 be be VB cord-354827-ipg1vwmv 173 21 studied study VBN cord-354827-ipg1vwmv 173 22 at at IN cord-354827-ipg1vwmv 173 23 databases database NNS cord-354827-ipg1vwmv 173 24 such such JJ cord-354827-ipg1vwmv 173 25 as as IN cord-354827-ipg1vwmv 173 26 InnateDB InnateDB NNP cord-354827-ipg1vwmv 173 27 http://www.innatedb.ca/. http://www.innatedb.ca/. DT cord-354827-ipg1vwmv 174 1 Such such JJ cord-354827-ipg1vwmv 174 2 analysis analysis NN cord-354827-ipg1vwmv 174 3 may may MD cord-354827-ipg1vwmv 174 4 highlight highlight VB cord-354827-ipg1vwmv 174 5 suitable suitable JJ cord-354827-ipg1vwmv 174 6 targets target NNS cord-354827-ipg1vwmv 174 7 that that WDT cord-354827-ipg1vwmv 174 8 could could MD cord-354827-ipg1vwmv 174 9 be be VB cord-354827-ipg1vwmv 174 10 tracked track VBN cord-354827-ipg1vwmv 174 11 in in IN cord-354827-ipg1vwmv 174 12 patients patient NNS cord-354827-ipg1vwmv 174 13 [ [ -LRB- cord-354827-ipg1vwmv 174 14 51 51 CD cord-354827-ipg1vwmv 174 15 ] ] -RRB- cord-354827-ipg1vwmv 174 16 . . . cord-354827-ipg1vwmv 175 1 Mass mass NN cord-354827-ipg1vwmv 175 2 spectrometry spectrometry NN cord-354827-ipg1vwmv 175 3 , , , cord-354827-ipg1vwmv 175 4 proteomics proteomic NNS cord-354827-ipg1vwmv 175 5 or or CC cord-354827-ipg1vwmv 175 6 similar similar JJ cord-354827-ipg1vwmv 175 7 expression expression NN cord-354827-ipg1vwmv 175 8 monitoring monitor VBG cord-354827-ipg1vwmv 175 9 technologies technology NNS cord-354827-ipg1vwmv 175 10 could could MD cord-354827-ipg1vwmv 175 11 be be VB cord-354827-ipg1vwmv 175 12 applied apply VBN cord-354827-ipg1vwmv 175 13 to to TO cord-354827-ipg1vwmv 175 14 identify identify VB cord-354827-ipg1vwmv 175 15 particular particular JJ cord-354827-ipg1vwmv 175 16 genes gene NNS cord-354827-ipg1vwmv 175 17 or or CC cord-354827-ipg1vwmv 175 18 pathways pathway NNS cord-354827-ipg1vwmv 175 19 that that WDT cord-354827-ipg1vwmv 175 20 are be VBP cord-354827-ipg1vwmv 175 21 functionally functionally RB cord-354827-ipg1vwmv 175 22 activated activate VBN cord-354827-ipg1vwmv 175 23 during during IN cord-354827-ipg1vwmv 175 24 typhoid typhoid NN cord-354827-ipg1vwmv 175 25 . . . cord-354827-ipg1vwmv 176 1 Once once RB cord-354827-ipg1vwmv 176 2 a a DT cord-354827-ipg1vwmv 176 3 gene gene NN cord-354827-ipg1vwmv 176 4 or or CC cord-354827-ipg1vwmv 176 5 transcriptional transcriptional JJ cord-354827-ipg1vwmv 176 6 pathway pathway NN cord-354827-ipg1vwmv 176 7 is be VBZ cord-354827-ipg1vwmv 176 8 identified identify VBN cord-354827-ipg1vwmv 176 9 , , , cord-354827-ipg1vwmv 176 10 expression expression NN cord-354827-ipg1vwmv 176 11 could could MD cord-354827-ipg1vwmv 176 12 be be VB cord-354827-ipg1vwmv 176 13 monitored monitor VBN cord-354827-ipg1vwmv 176 14 using use VBG cord-354827-ipg1vwmv 176 15 DNA dna NN cord-354827-ipg1vwmv 176 16 or or CC cord-354827-ipg1vwmv 176 17 protein protein NN cord-354827-ipg1vwmv 176 18 probes probe NNS cord-354827-ipg1vwmv 176 19 . . . cord-354827-ipg1vwmv 177 1 This this DT cord-354827-ipg1vwmv 177 2 approach approach NN cord-354827-ipg1vwmv 177 3 may may MD cord-354827-ipg1vwmv 177 4 be be VB cord-354827-ipg1vwmv 177 5 a a DT cord-354827-ipg1vwmv 177 6 long long JJ cord-354827-ipg1vwmv 177 7 term term NN cord-354827-ipg1vwmv 177 8 aim aim NN cord-354827-ipg1vwmv 177 9 and and CC cord-354827-ipg1vwmv 177 10 comparative comparative JJ cord-354827-ipg1vwmv 177 11 analysis analysis NN cord-354827-ipg1vwmv 177 12 with with IN cord-354827-ipg1vwmv 177 13 similar similar JJ cord-354827-ipg1vwmv 177 14 materials material NNS cord-354827-ipg1vwmv 177 15 from from IN cord-354827-ipg1vwmv 177 16 other other JJ cord-354827-ipg1vwmv 177 17 diseases disease NNS cord-354827-ipg1vwmv 177 18 would would MD cord-354827-ipg1vwmv 177 19 be be VB cord-354827-ipg1vwmv 177 20 an an DT cord-354827-ipg1vwmv 177 21 essential essential JJ cord-354827-ipg1vwmv 177 22 requirement requirement NN cord-354827-ipg1vwmv 177 23 . . . cord-354827-ipg1vwmv 178 1 Blood blood NN cord-354827-ipg1vwmv 178 2 would would MD cord-354827-ipg1vwmv 178 3 most most RBS cord-354827-ipg1vwmv 178 4 likely likely RB cord-354827-ipg1vwmv 178 5 be be VB cord-354827-ipg1vwmv 178 6 the the DT cord-354827-ipg1vwmv 178 7 assay assay NN cord-354827-ipg1vwmv 178 8 material material NN cord-354827-ipg1vwmv 178 9 of of IN cord-354827-ipg1vwmv 178 10 choice choice NN cord-354827-ipg1vwmv 178 11 and and CC cord-354827-ipg1vwmv 178 12 this this DT cord-354827-ipg1vwmv 178 13 in in IN cord-354827-ipg1vwmv 178 14 itself -PRON- PRP cord-354827-ipg1vwmv 178 15 may may MD cord-354827-ipg1vwmv 178 16 present present VB cord-354827-ipg1vwmv 178 17 limitations limitation NNS cord-354827-ipg1vwmv 178 18 if if IN cord-354827-ipg1vwmv 178 19 responses response NNS cord-354827-ipg1vwmv 178 20 are be VBP cord-354827-ipg1vwmv 178 21 localized localize VBN cord-354827-ipg1vwmv 178 22 to to IN cord-354827-ipg1vwmv 178 23 deeper deep JJR cord-354827-ipg1vwmv 178 24 tissues tissue NNS cord-354827-ipg1vwmv 178 25 . . . cord-354827-ipg1vwmv 179 1 However however RB cord-354827-ipg1vwmv 179 2 , , , cord-354827-ipg1vwmv 179 3 this this DT cord-354827-ipg1vwmv 179 4 approach approach NN cord-354827-ipg1vwmv 179 5 is be VBZ cord-354827-ipg1vwmv 179 6 highly highly RB cord-354827-ipg1vwmv 179 7 novel novel JJ cord-354827-ipg1vwmv 179 8 , , , cord-354827-ipg1vwmv 179 9 powerful powerful JJ cord-354827-ipg1vwmv 179 10 and and CC cord-354827-ipg1vwmv 179 11 worthy worthy JJ cord-354827-ipg1vwmv 179 12 of of IN cord-354827-ipg1vwmv 179 13 further further JJ cord-354827-ipg1vwmv 179 14 investigation investigation NN cord-354827-ipg1vwmv 179 15 and and CC cord-354827-ipg1vwmv 179 16 investment investment NN cord-354827-ipg1vwmv 179 17 . . . cord-354827-ipg1vwmv 180 1 An an DT cord-354827-ipg1vwmv 180 2 further further JJ cord-354827-ipg1vwmv 180 3 alternative alternative JJ cord-354827-ipg1vwmv 180 4 approach approach NN cord-354827-ipg1vwmv 180 5 would would MD cord-354827-ipg1vwmv 180 6 be be VB cord-354827-ipg1vwmv 180 7 to to TO cord-354827-ipg1vwmv 180 8 identify identify VB cord-354827-ipg1vwmv 180 9 potential potential JJ cord-354827-ipg1vwmv 180 10 biomarkers biomarker NNS cord-354827-ipg1vwmv 180 11 , , , cord-354827-ipg1vwmv 180 12 i.e. i.e. FW cord-354827-ipg1vwmv 180 13 discover discover VBP cord-354827-ipg1vwmv 180 14 a a DT cord-354827-ipg1vwmv 180 15 physiological physiological JJ cord-354827-ipg1vwmv 180 16 signature signature NN cord-354827-ipg1vwmv 180 17 or or CC cord-354827-ipg1vwmv 180 18 metabolic metabolic JJ cord-354827-ipg1vwmv 180 19 product product NN cord-354827-ipg1vwmv 180 20 associated associate VBN cord-354827-ipg1vwmv 180 21 with with IN cord-354827-ipg1vwmv 180 22 typhoid typhoid NN cord-354827-ipg1vwmv 180 23 . . . cord-354827-ipg1vwmv 181 1 The the DT cord-354827-ipg1vwmv 181 2 signature signature NN cord-354827-ipg1vwmv 181 3 could could MD cord-354827-ipg1vwmv 181 4 be be VB cord-354827-ipg1vwmv 181 5 of of IN cord-354827-ipg1vwmv 181 6 host host NN cord-354827-ipg1vwmv 181 7 or or CC cord-354827-ipg1vwmv 181 8 bacterial bacterial JJ cord-354827-ipg1vwmv 181 9 origin origin NN cord-354827-ipg1vwmv 181 10 or or CC cord-354827-ipg1vwmv 181 11 a a DT cord-354827-ipg1vwmv 181 12 combination combination NN cord-354827-ipg1vwmv 181 13 of of IN cord-354827-ipg1vwmv 181 14 both both DT cord-354827-ipg1vwmv 181 15 that that DT cord-354827-ipg1vwmv 181 16 is be VBZ cord-354827-ipg1vwmv 181 17 / / , cord-354827-ipg1vwmv 181 18 are be VBP cord-354827-ipg1vwmv 181 19 produced produce VBN cord-354827-ipg1vwmv 181 20 in in IN cord-354827-ipg1vwmv 181 21 real real JJ cord-354827-ipg1vwmv 181 22 time time NN cord-354827-ipg1vwmv 181 23 during during IN cord-354827-ipg1vwmv 181 24 infection infection NN cord-354827-ipg1vwmv 181 25 . . . cord-354827-ipg1vwmv 182 1 The the DT cord-354827-ipg1vwmv 182 2 science science NN cord-354827-ipg1vwmv 182 3 of of IN cord-354827-ipg1vwmv 182 4 host host NN cord-354827-ipg1vwmv 182 5 metabolomics metabolomic NNS cord-354827-ipg1vwmv 182 6 is be VBZ cord-354827-ipg1vwmv 182 7 growing grow VBG cord-354827-ipg1vwmv 182 8 with with IN cord-354827-ipg1vwmv 182 9 the the DT cord-354827-ipg1vwmv 182 10 development development NN cord-354827-ipg1vwmv 182 11 of of IN cord-354827-ipg1vwmv 182 12 applications application NNS cord-354827-ipg1vwmv 182 13 such such JJ cord-354827-ipg1vwmv 182 14 as as IN cord-354827-ipg1vwmv 182 15 NMR NMR NNP cord-354827-ipg1vwmv 182 16 and and CC cord-354827-ipg1vwmv 182 17 Mass Mass NNP cord-354827-ipg1vwmv 182 18 Spectrometric Spectrometric NNP cord-354827-ipg1vwmv 182 19 technologies technology NNS cord-354827-ipg1vwmv 182 20 . . . cord-354827-ipg1vwmv 183 1 Metabolomics metabolomic NNS cord-354827-ipg1vwmv 183 2 could could MD cord-354827-ipg1vwmv 183 3 , , , cord-354827-ipg1vwmv 183 4 theoretically theoretically RB cord-354827-ipg1vwmv 183 5 , , , cord-354827-ipg1vwmv 183 6 work work VB cord-354827-ipg1vwmv 183 7 on on IN cord-354827-ipg1vwmv 183 8 a a DT cord-354827-ipg1vwmv 183 9 range range NN cord-354827-ipg1vwmv 183 10 of of IN cord-354827-ipg1vwmv 183 11 bodily bodily JJ cord-354827-ipg1vwmv 183 12 fluids fluid NNS cord-354827-ipg1vwmv 183 13 , , , cord-354827-ipg1vwmv 183 14 including include VBG cord-354827-ipg1vwmv 183 15 blood blood NN cord-354827-ipg1vwmv 183 16 and and CC cord-354827-ipg1vwmv 183 17 urine urine NN cord-354827-ipg1vwmv 183 18 and and CC cord-354827-ipg1vwmv 183 19 may may MD cord-354827-ipg1vwmv 183 20 detect detect VB cord-354827-ipg1vwmv 183 21 specific specific JJ cord-354827-ipg1vwmv 183 22 small small JJ cord-354827-ipg1vwmv 183 23 or or CC cord-354827-ipg1vwmv 183 24 complex complex JJ cord-354827-ipg1vwmv 183 25 macromolecules macromolecule NNS cord-354827-ipg1vwmv 183 26 . . . cord-354827-ipg1vwmv 184 1 Some some DT cord-354827-ipg1vwmv 184 2 research research NN cord-354827-ipg1vwmv 184 3 groups group NNS cord-354827-ipg1vwmv 184 4 have have VBP cord-354827-ipg1vwmv 184 5 developed develop VBN cord-354827-ipg1vwmv 184 6 systems system NNS cord-354827-ipg1vwmv 184 7 for for IN cord-354827-ipg1vwmv 184 8 identifying identify VBG cord-354827-ipg1vwmv 184 9 biomarkers biomarker NNS cord-354827-ipg1vwmv 184 10 in in IN cord-354827-ipg1vwmv 184 11 biological biological JJ cord-354827-ipg1vwmv 184 12 material material NN cord-354827-ipg1vwmv 184 13 from from IN cord-354827-ipg1vwmv 184 14 patients patient NNS cord-354827-ipg1vwmv 184 15 infected infect VBN cord-354827-ipg1vwmv 184 16 with with IN cord-354827-ipg1vwmv 184 17 various various JJ cord-354827-ipg1vwmv 184 18 pathogens pathogen NNS cord-354827-ipg1vwmv 184 19 such such JJ cord-354827-ipg1vwmv 184 20 as as IN cord-354827-ipg1vwmv 184 21 Tuberculosis Tuberculosis NNP cord-354827-ipg1vwmv 184 22 [ [ -LRB- cord-354827-ipg1vwmv 184 23 52 52 CD cord-354827-ipg1vwmv 184 24 , , , cord-354827-ipg1vwmv 184 25 53 53 CD cord-354827-ipg1vwmv 184 26 ] ] -RRB- cord-354827-ipg1vwmv 184 27 . . . cord-354827-ipg1vwmv 185 1 Surface surface NN cord-354827-ipg1vwmv 185 2 - - HYPH cord-354827-ipg1vwmv 185 3 enhanced enhance VBN cord-354827-ipg1vwmv 185 4 laser laser NN cord-354827-ipg1vwmv 185 5 desorption desorption NN cord-354827-ipg1vwmv 185 6 / / SYM cord-354827-ipg1vwmv 185 7 ionization ionization NN cord-354827-ipg1vwmv 185 8 time time NN cord-354827-ipg1vwmv 185 9 - - HYPH cord-354827-ipg1vwmv 185 10 of of IN cord-354827-ipg1vwmv 185 11 - - HYPH cord-354827-ipg1vwmv 185 12 flight flight NN cord-354827-ipg1vwmv 185 13 ( ( -LRB- cord-354827-ipg1vwmv 185 14 SELDI SELDI NNP cord-354827-ipg1vwmv 185 15 - - HYPH cord-354827-ipg1vwmv 185 16 TOF TOF NNP cord-354827-ipg1vwmv 185 17 ) ) -RRB- cord-354827-ipg1vwmv 185 18 mass mass NN cord-354827-ipg1vwmv 185 19 spectroscopy spectroscopy NN cord-354827-ipg1vwmv 185 20 has have VBZ cord-354827-ipg1vwmv 185 21 also also RB cord-354827-ipg1vwmv 185 22 been be VBN cord-354827-ipg1vwmv 185 23 utilized utilize VBN cord-354827-ipg1vwmv 185 24 in in IN cord-354827-ipg1vwmv 185 25 studying study VBG cord-354827-ipg1vwmv 185 26 SARS SARS NNP cord-354827-ipg1vwmv 185 27 protein protein NN cord-354827-ipg1vwmv 185 28 biomarkers biomarker NNS cord-354827-ipg1vwmv 185 29 , , , cord-354827-ipg1vwmv 185 30 as as IN cord-354827-ipg1vwmv 185 31 reviewed review VBN cord-354827-ipg1vwmv 185 32 by by IN cord-354827-ipg1vwmv 185 33 Mazzulli Mazzulli NNP cord-354827-ipg1vwmv 185 34 et et FW cord-354827-ipg1vwmv 185 35 al al NNP cord-354827-ipg1vwmv 185 36 . . . cord-354827-ipg1vwmv 186 1 [ [ -LRB- cord-354827-ipg1vwmv 186 2 54 54 CD cord-354827-ipg1vwmv 186 3 ] ] -RRB- cord-354827-ipg1vwmv 186 4 . . . cord-354827-ipg1vwmv 187 1 SELDI SELDI NNP cord-354827-ipg1vwmv 187 2 - - HYPH cord-354827-ipg1vwmv 187 3 TOF TOF NNP cord-354827-ipg1vwmv 187 4 may may MD cord-354827-ipg1vwmv 187 5 add add VB cord-354827-ipg1vwmv 187 6 insight insight NN cord-354827-ipg1vwmv 187 7 into into IN cord-354827-ipg1vwmv 187 8 those those DT cord-354827-ipg1vwmv 187 9 proteins protein NNS cord-354827-ipg1vwmv 187 10 that that WDT cord-354827-ipg1vwmv 187 11 are be VBP cord-354827-ipg1vwmv 187 12 expressed express VBN cord-354827-ipg1vwmv 187 13 in in IN cord-354827-ipg1vwmv 187 14 serum serum NN cord-354827-ipg1vwmv 187 15 , , , cord-354827-ipg1vwmv 187 16 blood blood NN cord-354827-ipg1vwmv 187 17 , , , cord-354827-ipg1vwmv 187 18 saliva saliva NN cord-354827-ipg1vwmv 187 19 , , , cord-354827-ipg1vwmv 187 20 urine urine NN cord-354827-ipg1vwmv 187 21 or or CC cord-354827-ipg1vwmv 187 22 any any DT cord-354827-ipg1vwmv 187 23 other other JJ cord-354827-ipg1vwmv 187 24 biological biological JJ cord-354827-ipg1vwmv 187 25 material material NN cord-354827-ipg1vwmv 187 26 that that WDT cord-354827-ipg1vwmv 187 27 may may MD cord-354827-ipg1vwmv 187 28 harbor harbor VB cord-354827-ipg1vwmv 187 29 specific specific JJ cord-354827-ipg1vwmv 187 30 markers marker NNS cord-354827-ipg1vwmv 187 31 for for IN cord-354827-ipg1vwmv 187 32 typhoid typhoid NN cord-354827-ipg1vwmv 187 33 infections infection NNS cord-354827-ipg1vwmv 187 34 . . . cord-354827-ipg1vwmv 188 1 Some some DT cord-354827-ipg1vwmv 188 2 early early JJ cord-354827-ipg1vwmv 188 3 studies study NNS cord-354827-ipg1vwmv 188 4 on on IN cord-354827-ipg1vwmv 188 5 pathogenesis pathogenesis NN cord-354827-ipg1vwmv 188 6 and and CC cord-354827-ipg1vwmv 188 7 diagnostics diagnostic NNS cord-354827-ipg1vwmv 188 8 did do VBD cord-354827-ipg1vwmv 188 9 focus focus VB cord-354827-ipg1vwmv 188 10 on on IN cord-354827-ipg1vwmv 188 11 the the DT cord-354827-ipg1vwmv 188 12 detection detection NN cord-354827-ipg1vwmv 188 13 of of IN cord-354827-ipg1vwmv 188 14 S. S. NNP cord-354827-ipg1vwmv 188 15 Typhi Typhi NNP cord-354827-ipg1vwmv 188 16 antigens antigen NNS cord-354827-ipg1vwmv 188 17 such such JJ cord-354827-ipg1vwmv 188 18 as as IN cord-354827-ipg1vwmv 188 19 Vi Vi NNP cord-354827-ipg1vwmv 188 20 in in IN cord-354827-ipg1vwmv 188 21 the the DT cord-354827-ipg1vwmv 188 22 urine urine NN cord-354827-ipg1vwmv 188 23 of of IN cord-354827-ipg1vwmv 188 24 patients patient NNS cord-354827-ipg1vwmv 188 25 and and CC cord-354827-ipg1vwmv 188 26 this this DT cord-354827-ipg1vwmv 188 27 is be VBZ cord-354827-ipg1vwmv 188 28 worth worth JJ cord-354827-ipg1vwmv 188 29 revisiting revisit VBG cord-354827-ipg1vwmv 188 30 in in IN cord-354827-ipg1vwmv 188 31 view view NN cord-354827-ipg1vwmv 188 32 of of IN cord-354827-ipg1vwmv 188 33 a a DT cord-354827-ipg1vwmv 188 34 substantial substantial JJ cord-354827-ipg1vwmv 188 35 increase increase NN cord-354827-ipg1vwmv 188 36 in in IN cord-354827-ipg1vwmv 188 37 the the DT cord-354827-ipg1vwmv 188 38 sensitivity sensitivity NN cord-354827-ipg1vwmv 188 39 of of IN cord-354827-ipg1vwmv 188 40 detection detection NN cord-354827-ipg1vwmv 188 41 technologies technology NNS cord-354827-ipg1vwmv 188 42 [ [ -LRB- cord-354827-ipg1vwmv 188 43 55 55 CD cord-354827-ipg1vwmv 188 44 , , , cord-354827-ipg1vwmv 188 45 56 56 CD cord-354827-ipg1vwmv 188 46 ] ] -RRB- cord-354827-ipg1vwmv 188 47 . . . cord-354827-ipg1vwmv 189 1 What what WP cord-354827-ipg1vwmv 189 2 about about IN cord-354827-ipg1vwmv 189 3 the the DT cord-354827-ipg1vwmv 189 4 diagnosis diagnosis NN cord-354827-ipg1vwmv 189 5 of of IN cord-354827-ipg1vwmv 189 6 typhoid typhoid NN cord-354827-ipg1vwmv 189 7 in in IN cord-354827-ipg1vwmv 189 8 carriers carrier NNS cord-354827-ipg1vwmv 189 9 infected infect VBN cord-354827-ipg1vwmv 189 10 with with IN cord-354827-ipg1vwmv 189 11 S. S. NNP cord-354827-ipg1vwmv 189 12 Typhi Typhi NNP cord-354827-ipg1vwmv 189 13 or or CC cord-354827-ipg1vwmv 189 14 S. S. NNP cord-354827-ipg1vwmv 189 15 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 190 1 A a DT cord-354827-ipg1vwmv 190 2 [ [ -LRB- cord-354827-ipg1vwmv 190 3 57 57 CD cord-354827-ipg1vwmv 190 4 , , , cord-354827-ipg1vwmv 190 5 58 58 CD cord-354827-ipg1vwmv 190 6 ] ] -RRB- cord-354827-ipg1vwmv 190 7 ? ? . cord-354827-ipg1vwmv 191 1 Clearly clearly RB cord-354827-ipg1vwmv 191 2 , , , cord-354827-ipg1vwmv 191 3 such such JJ cord-354827-ipg1vwmv 191 4 individuals individual NNS cord-354827-ipg1vwmv 191 5 warrant warrant VBP cord-354827-ipg1vwmv 191 6 special special JJ cord-354827-ipg1vwmv 191 7 consideration consideration NN cord-354827-ipg1vwmv 191 8 as as IN cord-354827-ipg1vwmv 191 9 they -PRON- PRP cord-354827-ipg1vwmv 191 10 are be VBP cord-354827-ipg1vwmv 191 11 a a DT cord-354827-ipg1vwmv 191 12 silent silent JJ cord-354827-ipg1vwmv 191 13 threat threat NN cord-354827-ipg1vwmv 191 14 to to IN cord-354827-ipg1vwmv 191 15 others other NNS cord-354827-ipg1vwmv 191 16 in in IN cord-354827-ipg1vwmv 191 17 the the DT cord-354827-ipg1vwmv 191 18 population population NN cord-354827-ipg1vwmv 191 19 . . . cord-354827-ipg1vwmv 192 1 Monitoring Monitoring NNP cord-354827-ipg1vwmv 192 2 S. S. NNP cord-354827-ipg1vwmv 192 3 Typhi Typhi NNP cord-354827-ipg1vwmv 192 4 in in IN cord-354827-ipg1vwmv 192 5 the the DT cord-354827-ipg1vwmv 192 6 stool stool NN cord-354827-ipg1vwmv 192 7 is be VBZ cord-354827-ipg1vwmv 192 8 one one CD cord-354827-ipg1vwmv 192 9 option option NN cord-354827-ipg1vwmv 192 10 but but CC cord-354827-ipg1vwmv 192 11 shedding shedding NN cord-354827-ipg1vwmv 192 12 may may MD cord-354827-ipg1vwmv 192 13 be be VB cord-354827-ipg1vwmv 192 14 low low JJ cord-354827-ipg1vwmv 192 15 level level NN cord-354827-ipg1vwmv 192 16 or or CC cord-354827-ipg1vwmv 192 17 sporadic sporadic JJ cord-354827-ipg1vwmv 192 18 . . . cord-354827-ipg1vwmv 193 1 Further further RB cord-354827-ipg1vwmv 193 2 , , , cord-354827-ipg1vwmv 193 3 stool stool NN cord-354827-ipg1vwmv 193 4 sampling sampling NN cord-354827-ipg1vwmv 193 5 at at IN cord-354827-ipg1vwmv 193 6 a a DT cord-354827-ipg1vwmv 193 7 routine routine JJ cord-354827-ipg1vwmv 193 8 level level NN cord-354827-ipg1vwmv 193 9 is be VBZ cord-354827-ipg1vwmv 193 10 expensive expensive JJ cord-354827-ipg1vwmv 193 11 , , , cord-354827-ipg1vwmv 193 12 time time NN cord-354827-ipg1vwmv 193 13 consuming consume VBG cord-354827-ipg1vwmv 193 14 and and CC cord-354827-ipg1vwmv 193 15 unpopular unpopular JJ cord-354827-ipg1vwmv 193 16 , , , cord-354827-ipg1vwmv 193 17 although although IN cord-354827-ipg1vwmv 193 18 improved improve VBN cord-354827-ipg1vwmv 193 19 bacterial bacterial JJ cord-354827-ipg1vwmv 193 20 recovery recovery NN cord-354827-ipg1vwmv 193 21 methods method NNS cord-354827-ipg1vwmv 193 22 could could MD cord-354827-ipg1vwmv 193 23 be be VB cord-354827-ipg1vwmv 193 24 one one CD cord-354827-ipg1vwmv 193 25 approach approach NN cord-354827-ipg1vwmv 193 26 . . . cord-354827-ipg1vwmv 194 1 We -PRON- PRP cord-354827-ipg1vwmv 194 2 know know VBP cord-354827-ipg1vwmv 194 3 of of IN cord-354827-ipg1vwmv 194 4 no no DT cord-354827-ipg1vwmv 194 5 obvious obvious JJ cord-354827-ipg1vwmv 194 6 signature signature NN cord-354827-ipg1vwmv 194 7 that that WDT cord-354827-ipg1vwmv 194 8 can can MD cord-354827-ipg1vwmv 194 9 be be VB cord-354827-ipg1vwmv 194 10 used use VBN cord-354827-ipg1vwmv 194 11 to to TO cord-354827-ipg1vwmv 194 12 categorically categorically RB cord-354827-ipg1vwmv 194 13 identify identify VB cord-354827-ipg1vwmv 194 14 S. S. NNP cord-354827-ipg1vwmv 194 15 Typhi Typhi NNP cord-354827-ipg1vwmv 194 16 carriers carrier NNS cord-354827-ipg1vwmv 194 17 . . . cord-354827-ipg1vwmv 195 1 However however RB cord-354827-ipg1vwmv 195 2 , , , cord-354827-ipg1vwmv 195 3 important important JJ cord-354827-ipg1vwmv 195 4 studies study NNS cord-354827-ipg1vwmv 195 5 have have VBP cord-354827-ipg1vwmv 195 6 indicated indicate VBN cord-354827-ipg1vwmv 195 7 that that IN cord-354827-ipg1vwmv 195 8 typhoid typhoid NN cord-354827-ipg1vwmv 195 9 carriers carrier NNS cord-354827-ipg1vwmv 195 10 may may MD cord-354827-ipg1vwmv 195 11 produce produce VB cord-354827-ipg1vwmv 195 12 higher high JJR cord-354827-ipg1vwmv 195 13 levels level NNS cord-354827-ipg1vwmv 195 14 of of IN cord-354827-ipg1vwmv 195 15 Vi Vi NNP cord-354827-ipg1vwmv 195 16 antibodies antibody NNS cord-354827-ipg1vwmv 195 17 over over IN cord-354827-ipg1vwmv 195 18 extended extend VBN cord-354827-ipg1vwmv 195 19 periods period NNS cord-354827-ipg1vwmv 195 20 compared compare VBN cord-354827-ipg1vwmv 195 21 to to IN cord-354827-ipg1vwmv 195 22 acutely acutely RB cord-354827-ipg1vwmv 195 23 infected infect VBN cord-354827-ipg1vwmv 195 24 patients patient NNS cord-354827-ipg1vwmv 195 25 [ [ -LRB- cord-354827-ipg1vwmv 195 26 59 59 CD cord-354827-ipg1vwmv 195 27 , , , cord-354827-ipg1vwmv 195 28 60 60 CD cord-354827-ipg1vwmv 195 29 ] ] -RRB- cord-354827-ipg1vwmv 195 30 . . . cord-354827-ipg1vwmv 196 1 This this DT cord-354827-ipg1vwmv 196 2 may may MD cord-354827-ipg1vwmv 196 3 be be VB cord-354827-ipg1vwmv 196 4 in in IN cord-354827-ipg1vwmv 196 5 part part NN cord-354827-ipg1vwmv 196 6 because because IN cord-354827-ipg1vwmv 196 7 Vi Vi NNP cord-354827-ipg1vwmv 196 8 is be VBZ cord-354827-ipg1vwmv 196 9 a a DT cord-354827-ipg1vwmv 196 10 polysaccharide polysaccharide NN cord-354827-ipg1vwmv 196 11 and and CC cord-354827-ipg1vwmv 196 12 the the DT cord-354827-ipg1vwmv 196 13 immune immune JJ cord-354827-ipg1vwmv 196 14 response response NN cord-354827-ipg1vwmv 196 15 to to IN cord-354827-ipg1vwmv 196 16 Vi Vi NNP cord-354827-ipg1vwmv 196 17 is be VBZ cord-354827-ipg1vwmv 196 18 T T NNP cord-354827-ipg1vwmv 196 19 cell cell NN cord-354827-ipg1vwmv 196 20 - - HYPH cord-354827-ipg1vwmv 196 21 independent independent JJ cord-354827-ipg1vwmv 196 22 , , , cord-354827-ipg1vwmv 196 23 stimulating stimulate VBG cord-354827-ipg1vwmv 196 24 poor poor JJ cord-354827-ipg1vwmv 196 25 memory memory NN cord-354827-ipg1vwmv 196 26 . . . cord-354827-ipg1vwmv 197 1 However however RB cord-354827-ipg1vwmv 197 2 , , , cord-354827-ipg1vwmv 197 3 carriers carrier NNS cord-354827-ipg1vwmv 197 4 may may MD cord-354827-ipg1vwmv 197 5 receive receive VB cord-354827-ipg1vwmv 197 6 continual continual JJ cord-354827-ipg1vwmv 197 7 , , , cord-354827-ipg1vwmv 197 8 natural natural JJ cord-354827-ipg1vwmv 197 9 boosting boosting NN cord-354827-ipg1vwmv 197 10 when when WRB cord-354827-ipg1vwmv 197 11 the the DT cord-354827-ipg1vwmv 197 12 organisms organism NNS cord-354827-ipg1vwmv 197 13 are be VBP cord-354827-ipg1vwmv 197 14 reseeded reseed VBN cord-354827-ipg1vwmv 197 15 , , , cord-354827-ipg1vwmv 197 16 potentially potentially RB cord-354827-ipg1vwmv 197 17 in in IN cord-354827-ipg1vwmv 197 18 high high JJ cord-354827-ipg1vwmv 197 19 numbers number NNS cord-354827-ipg1vwmv 197 20 ( ( -LRB- cord-354827-ipg1vwmv 197 21 Figure figure NN cord-354827-ipg1vwmv 197 22 2 2 CD cord-354827-ipg1vwmv 197 23 ) ) -RRB- cord-354827-ipg1vwmv 197 24 , , , cord-354827-ipg1vwmv 197 25 back back RB cord-354827-ipg1vwmv 197 26 into into IN cord-354827-ipg1vwmv 197 27 the the DT cord-354827-ipg1vwmv 197 28 intestinal intestinal JJ cord-354827-ipg1vwmv 197 29 tract tract NN cord-354827-ipg1vwmv 197 30 . . . cord-354827-ipg1vwmv 198 1 If if IN cord-354827-ipg1vwmv 198 2 we -PRON- PRP cord-354827-ipg1vwmv 198 3 could could MD cord-354827-ipg1vwmv 198 4 develop develop VB cord-354827-ipg1vwmv 198 5 simple simple JJ cord-354827-ipg1vwmv 198 6 , , , cord-354827-ipg1vwmv 198 7 cheap cheap JJ cord-354827-ipg1vwmv 198 8 and and CC cord-354827-ipg1vwmv 198 9 none none NN cord-354827-ipg1vwmv 198 10 invasive invasive JJ cord-354827-ipg1vwmv 198 11 Vi Vi NNP cord-354827-ipg1vwmv 198 12 antibody antibody NN cord-354827-ipg1vwmv 198 13 assays assay NNS cord-354827-ipg1vwmv 198 14 these these DT cord-354827-ipg1vwmv 198 15 may may MD cord-354827-ipg1vwmv 198 16 prove prove VB cord-354827-ipg1vwmv 198 17 valuable valuable JJ cord-354827-ipg1vwmv 198 18 in in IN cord-354827-ipg1vwmv 198 19 identifying identify VBG cord-354827-ipg1vwmv 198 20 carriers carrier NNS cord-354827-ipg1vwmv 198 21 . . . cord-354827-ipg1vwmv 199 1 The the DT cord-354827-ipg1vwmv 199 2 ultimate ultimate JJ cord-354827-ipg1vwmv 199 3 question question NN cord-354827-ipg1vwmv 199 4 is be VBZ cord-354827-ipg1vwmv 199 5 which which WDT cord-354827-ipg1vwmv 199 6 direction direction NN cord-354827-ipg1vwmv 199 7 do do VBP cord-354827-ipg1vwmv 199 8 we -PRON- PRP cord-354827-ipg1vwmv 199 9 follow follow VB cord-354827-ipg1vwmv 199 10 in in IN cord-354827-ipg1vwmv 199 11 terms term NNS cord-354827-ipg1vwmv 199 12 of of IN cord-354827-ipg1vwmv 199 13 developing develop VBG cord-354827-ipg1vwmv 199 14 typhoid typhoid NN cord-354827-ipg1vwmv 199 15 diagnostics diagnostic NNS cord-354827-ipg1vwmv 199 16 and and CC cord-354827-ipg1vwmv 199 17 how how WRB cord-354827-ipg1vwmv 199 18 can can MD cord-354827-ipg1vwmv 199 19 these these DT cord-354827-ipg1vwmv 199 20 be be VB cord-354827-ipg1vwmv 199 21 applied apply VBN cord-354827-ipg1vwmv 199 22 to to IN cord-354827-ipg1vwmv 199 23 location location NN cord-354827-ipg1vwmv 199 24 with with IN cord-354827-ipg1vwmv 199 25 limited limited JJ cord-354827-ipg1vwmv 199 26 resources resource NNS cord-354827-ipg1vwmv 199 27 ? ? . cord-354827-ipg1vwmv 200 1 In in IN cord-354827-ipg1vwmv 200 2 the the DT cord-354827-ipg1vwmv 200 3 short short JJ cord-354827-ipg1vwmv 200 4 term term NN cord-354827-ipg1vwmv 200 5 , , , cord-354827-ipg1vwmv 200 6 it -PRON- PRP cord-354827-ipg1vwmv 200 7 appears appear VBZ cord-354827-ipg1vwmv 200 8 that that IN cord-354827-ipg1vwmv 200 9 whilst whilst IN cord-354827-ipg1vwmv 200 10 current current JJ cord-354827-ipg1vwmv 200 11 techniques technique NNS cord-354827-ipg1vwmv 200 12 are be VBP cord-354827-ipg1vwmv 200 13 limited limit VBN cord-354827-ipg1vwmv 200 14 there there EX cord-354827-ipg1vwmv 200 15 is be VBZ cord-354827-ipg1vwmv 200 16 no no DT cord-354827-ipg1vwmv 200 17 real real JJ cord-354827-ipg1vwmv 200 18 alternative alternative NN cord-354827-ipg1vwmv 200 19 without without IN cord-354827-ipg1vwmv 200 20 extensive extensive JJ cord-354827-ipg1vwmv 200 21 research research NN cord-354827-ipg1vwmv 200 22 and and CC cord-354827-ipg1vwmv 200 23 culturing culturing NN cord-354827-ipg1vwmv 200 24 remains remain VBZ cord-354827-ipg1vwmv 200 25 the the DT cord-354827-ipg1vwmv 200 26 inadequate inadequate JJ cord-354827-ipg1vwmv 200 27 gold gold NN cord-354827-ipg1vwmv 200 28 standard standard NN cord-354827-ipg1vwmv 200 29 . . . cord-354827-ipg1vwmv 201 1 However however RB cord-354827-ipg1vwmv 201 2 , , , cord-354827-ipg1vwmv 201 3 laboratories laboratory NNS cord-354827-ipg1vwmv 201 4 in in IN cord-354827-ipg1vwmv 201 5 developing develop VBG cord-354827-ipg1vwmv 201 6 countries country NNS cord-354827-ipg1vwmv 201 7 with with IN cord-354827-ipg1vwmv 201 8 typhoid typhoid NN cord-354827-ipg1vwmv 201 9 should should MD cord-354827-ipg1vwmv 201 10 be be VB cord-354827-ipg1vwmv 201 11 prepared prepared JJ cord-354827-ipg1vwmv 201 12 to to TO cord-354827-ipg1vwmv 201 13 evaluate evaluate VB cord-354827-ipg1vwmv 201 14 new new JJ cord-354827-ipg1vwmv 201 15 diagnostics diagnostic NNS cord-354827-ipg1vwmv 201 16 as as IN cord-354827-ipg1vwmv 201 17 they -PRON- PRP cord-354827-ipg1vwmv 201 18 evolve evolve VBP cord-354827-ipg1vwmv 201 19 . . . cord-354827-ipg1vwmv 202 1 As as IN cord-354827-ipg1vwmv 202 2 a a DT cord-354827-ipg1vwmv 202 3 way way NN cord-354827-ipg1vwmv 202 4 forward forward RB cord-354827-ipg1vwmv 202 5 for for IN cord-354827-ipg1vwmv 202 6 culture culture NN cord-354827-ipg1vwmv 202 7 , , , cord-354827-ipg1vwmv 202 8 it -PRON- PRP cord-354827-ipg1vwmv 202 9 may may MD cord-354827-ipg1vwmv 202 10 be be VB cord-354827-ipg1vwmv 202 11 prudent prudent JJ cord-354827-ipg1vwmv 202 12 to to TO cord-354827-ipg1vwmv 202 13 investigate investigate VB cord-354827-ipg1vwmv 202 14 specialized specialized JJ cord-354827-ipg1vwmv 202 15 growth growth NN cord-354827-ipg1vwmv 202 16 media medium NNS cord-354827-ipg1vwmv 202 17 that that WDT cord-354827-ipg1vwmv 202 18 would would MD cord-354827-ipg1vwmv 202 19 favor favor VB cord-354827-ipg1vwmv 202 20 the the DT cord-354827-ipg1vwmv 202 21 regeneration regeneration NN cord-354827-ipg1vwmv 202 22 of of IN cord-354827-ipg1vwmv 202 23 S. S. NNP cord-354827-ipg1vwmv 202 24 Typhi Typhi NNP cord-354827-ipg1vwmv 202 25 from from IN cord-354827-ipg1vwmv 202 26 blood blood NN cord-354827-ipg1vwmv 202 27 . . . cord-354827-ipg1vwmv 203 1 Simple simple JJ cord-354827-ipg1vwmv 203 2 methods method NNS cord-354827-ipg1vwmv 203 3 for for IN cord-354827-ipg1vwmv 203 4 enriching enrich VBG cord-354827-ipg1vwmv 203 5 the the DT cord-354827-ipg1vwmv 203 6 small small JJ cord-354827-ipg1vwmv 203 7 population population NN cord-354827-ipg1vwmv 203 8 of of IN cord-354827-ipg1vwmv 203 9 bacteria bacteria NNS cord-354827-ipg1vwmv 203 10 present present JJ cord-354827-ipg1vwmv 203 11 in in IN cord-354827-ipg1vwmv 203 12 blood blood NN cord-354827-ipg1vwmv 203 13 using use VBG cord-354827-ipg1vwmv 203 14 simple simple JJ cord-354827-ipg1vwmv 203 15 direct direct JJ cord-354827-ipg1vwmv 203 16 enrichment enrichment NN cord-354827-ipg1vwmv 203 17 procedures procedure NNS cord-354827-ipg1vwmv 203 18 that that WDT cord-354827-ipg1vwmv 203 19 do do VBP cord-354827-ipg1vwmv 203 20 not not RB cord-354827-ipg1vwmv 203 21 rely rely VB cord-354827-ipg1vwmv 203 22 on on IN cord-354827-ipg1vwmv 203 23 growth growth NN cord-354827-ipg1vwmv 203 24 could could MD cord-354827-ipg1vwmv 203 25 be be VB cord-354827-ipg1vwmv 203 26 considered consider VBN cord-354827-ipg1vwmv 203 27 . . . cord-354827-ipg1vwmv 204 1 DNA dna NN cord-354827-ipg1vwmv 204 2 methodology methodology NN cord-354827-ipg1vwmv 204 3 has have VBZ cord-354827-ipg1vwmv 204 4 specific specific JJ cord-354827-ipg1vwmv 204 5 limitations limitation NNS cord-354827-ipg1vwmv 204 6 that that WDT cord-354827-ipg1vwmv 204 7 are be VBP cord-354827-ipg1vwmv 204 8 similar similar JJ cord-354827-ipg1vwmv 204 9 to to IN cord-354827-ipg1vwmv 204 10 those those DT cord-354827-ipg1vwmv 204 11 presented present VBN cord-354827-ipg1vwmv 204 12 with with IN cord-354827-ipg1vwmv 204 13 bacterial bacterial JJ cord-354827-ipg1vwmv 204 14 culture culture NN cord-354827-ipg1vwmv 204 15 . . . cord-354827-ipg1vwmv 205 1 Advancement advancement NN cord-354827-ipg1vwmv 205 2 in in IN cord-354827-ipg1vwmv 205 3 this this DT cord-354827-ipg1vwmv 205 4 field field NN cord-354827-ipg1vwmv 205 5 would would MD cord-354827-ipg1vwmv 205 6 require require VB cord-354827-ipg1vwmv 205 7 the the DT cord-354827-ipg1vwmv 205 8 capture capture NN cord-354827-ipg1vwmv 205 9 and and CC cord-354827-ipg1vwmv 205 10 amplification amplification NN cord-354827-ipg1vwmv 205 11 from from IN cord-354827-ipg1vwmv 205 12 a a DT cord-354827-ipg1vwmv 205 13 smaller small JJR cord-354827-ipg1vwmv 205 14 number number NN cord-354827-ipg1vwmv 205 15 ( ( -LRB- cord-354827-ipg1vwmv 205 16 maybe maybe RB cord-354827-ipg1vwmv 205 17 even even RB cord-354827-ipg1vwmv 205 18 a a DT cord-354827-ipg1vwmv 205 19 single single JJ cord-354827-ipg1vwmv 205 20 organism organism NN cord-354827-ipg1vwmv 205 21 ) ) -RRB- cord-354827-ipg1vwmv 205 22 from from IN cord-354827-ipg1vwmv 205 23 blood blood NN cord-354827-ipg1vwmv 205 24 or or CC cord-354827-ipg1vwmv 205 25 other other JJ cord-354827-ipg1vwmv 205 26 bodily bodily JJ cord-354827-ipg1vwmv 205 27 fluids fluid NNS cord-354827-ipg1vwmv 205 28 . . . cord-354827-ipg1vwmv 206 1 Such such JJ cord-354827-ipg1vwmv 206 2 a a DT cord-354827-ipg1vwmv 206 3 task task NN cord-354827-ipg1vwmv 206 4 is be VBZ cord-354827-ipg1vwmv 206 5 not not RB cord-354827-ipg1vwmv 206 6 insurmountable insurmountable JJ cord-354827-ipg1vwmv 206 7 but but CC cord-354827-ipg1vwmv 206 8 it -PRON- PRP cord-354827-ipg1vwmv 206 9 will will MD cord-354827-ipg1vwmv 206 10 be be VB cord-354827-ipg1vwmv 206 11 a a DT cord-354827-ipg1vwmv 206 12 challenge challenge NN cord-354827-ipg1vwmv 206 13 to to TO cord-354827-ipg1vwmv 206 14 make make VB cord-354827-ipg1vwmv 206 15 it -PRON- PRP cord-354827-ipg1vwmv 206 16 cost cost VB cord-354827-ipg1vwmv 206 17 effective effective JJ cord-354827-ipg1vwmv 206 18 . . . cord-354827-ipg1vwmv 207 1 Serological serological JJ cord-354827-ipg1vwmv 207 2 advancements advancement NNS cord-354827-ipg1vwmv 207 3 will will MD cord-354827-ipg1vwmv 207 4 rely rely VB cord-354827-ipg1vwmv 207 5 on on IN cord-354827-ipg1vwmv 207 6 the the DT cord-354827-ipg1vwmv 207 7 identification identification NN cord-354827-ipg1vwmv 207 8 of of IN cord-354827-ipg1vwmv 207 9 novel novel NN cord-354827-ipg1vwmv 207 10 S. S. NNP cord-354827-ipg1vwmv 207 11 Typhi Typhi NNP cord-354827-ipg1vwmv 207 12 - - HYPH cord-354827-ipg1vwmv 207 13 specific specific JJ cord-354827-ipg1vwmv 207 14 antigens antigen NNS cord-354827-ipg1vwmv 207 15 that that WDT cord-354827-ipg1vwmv 207 16 are be VBP cord-354827-ipg1vwmv 207 17 conserved conserve VBN cord-354827-ipg1vwmv 207 18 and and CC cord-354827-ipg1vwmv 207 19 highly highly RB cord-354827-ipg1vwmv 207 20 immunogenic immunogenic JJ cord-354827-ipg1vwmv 207 21 in in IN cord-354827-ipg1vwmv 207 22 the the DT cord-354827-ipg1vwmv 207 23 human human JJ cord-354827-ipg1vwmv 207 24 host host NN cord-354827-ipg1vwmv 207 25 . . . cord-354827-ipg1vwmv 208 1 We -PRON- PRP cord-354827-ipg1vwmv 208 2 will will MD cord-354827-ipg1vwmv 208 3 need need VB cord-354827-ipg1vwmv 208 4 simple simple JJ cord-354827-ipg1vwmv 208 5 methods method NNS cord-354827-ipg1vwmv 208 6 to to TO cord-354827-ipg1vwmv 208 7 prepare prepare VB cord-354827-ipg1vwmv 208 8 highly highly RB cord-354827-ipg1vwmv 208 9 purified purify VBN cord-354827-ipg1vwmv 208 10 antigens antigen NNS cord-354827-ipg1vwmv 208 11 free free JJ cord-354827-ipg1vwmv 208 12 of of IN cord-354827-ipg1vwmv 208 13 potentially potentially RB cord-354827-ipg1vwmv 208 14 cross cross NN cord-354827-ipg1vwmv 208 15 reacting react VBG cord-354827-ipg1vwmv 208 16 materials material NNS cord-354827-ipg1vwmv 208 17 and and CC cord-354827-ipg1vwmv 208 18 antigen antigen NN cord-354827-ipg1vwmv 208 19 pools pool NNS cord-354827-ipg1vwmv 208 20 may may MD cord-354827-ipg1vwmv 208 21 be be VB cord-354827-ipg1vwmv 208 22 needed need VBN cord-354827-ipg1vwmv 208 23 to to TO cord-354827-ipg1vwmv 208 24 increase increase VB cord-354827-ipg1vwmv 208 25 sensitivity sensitivity NN cord-354827-ipg1vwmv 208 26 . . . cord-354827-ipg1vwmv 209 1 Serological serological JJ cord-354827-ipg1vwmv 209 2 approaches approach NNS cord-354827-ipg1vwmv 209 3 may may MD cord-354827-ipg1vwmv 209 4 be be VB cord-354827-ipg1vwmv 209 5 more more RBR cord-354827-ipg1vwmv 209 6 tractable tractable JJ cord-354827-ipg1vwmv 209 7 to to TO cord-354827-ipg1vwmv 209 8 convert convert VB cord-354827-ipg1vwmv 209 9 into into IN cord-354827-ipg1vwmv 209 10 a a DT cord-354827-ipg1vwmv 209 11 simple simple JJ cord-354827-ipg1vwmv 209 12 , , , cord-354827-ipg1vwmv 209 13 cheap cheap JJ cord-354827-ipg1vwmv 209 14 and and CC cord-354827-ipg1vwmv 209 15 rapid rapid JJ cord-354827-ipg1vwmv 209 16 test test NN cord-354827-ipg1vwmv 209 17 . . . cord-354827-ipg1vwmv 210 1 Host host NN cord-354827-ipg1vwmv 210 2 response response NN cord-354827-ipg1vwmv 210 3 assays assay NNS cord-354827-ipg1vwmv 210 4 will will MD cord-354827-ipg1vwmv 210 5 have have VB cord-354827-ipg1vwmv 210 6 to to TO cord-354827-ipg1vwmv 210 7 be be VB cord-354827-ipg1vwmv 210 8 developed develop VBN cord-354827-ipg1vwmv 210 9 through through IN cord-354827-ipg1vwmv 210 10 the the DT cord-354827-ipg1vwmv 210 11 application application NN cord-354827-ipg1vwmv 210 12 of of IN cord-354827-ipg1vwmv 210 13 genomics genomic NNS cord-354827-ipg1vwmv 210 14 and and CC cord-354827-ipg1vwmv 210 15 highly highly RB cord-354827-ipg1vwmv 210 16 sensitive sensitive JJ cord-354827-ipg1vwmv 210 17 Mass Mass NNP cord-354827-ipg1vwmv 210 18 Spectrometric Spectrometric NNP cord-354827-ipg1vwmv 210 19 , , , cord-354827-ipg1vwmv 210 20 NMR NMR NNP cord-354827-ipg1vwmv 210 21 or or CC cord-354827-ipg1vwmv 210 22 similar similar JJ cord-354827-ipg1vwmv 210 23 sensitive sensitive JJ cord-354827-ipg1vwmv 210 24 physical physical JJ cord-354827-ipg1vwmv 210 25 assays assay NNS cord-354827-ipg1vwmv 210 26 . . . cord-354827-ipg1vwmv 211 1 Looking look VBG cord-354827-ipg1vwmv 211 2 for for IN cord-354827-ipg1vwmv 211 3 host host NN cord-354827-ipg1vwmv 211 4 or or CC cord-354827-ipg1vwmv 211 5 pathogen pathogen NN cord-354827-ipg1vwmv 211 6 material material NN cord-354827-ipg1vwmv 211 7 in in IN cord-354827-ipg1vwmv 211 8 biological biological JJ cord-354827-ipg1vwmv 211 9 samples sample NNS cord-354827-ipg1vwmv 211 10 is be VBZ cord-354827-ipg1vwmv 211 11 an an DT cord-354827-ipg1vwmv 211 12 area area NN cord-354827-ipg1vwmv 211 13 that that WDT cord-354827-ipg1vwmv 211 14 clearly clearly RB cord-354827-ipg1vwmv 211 15 warrants warrant VBZ cord-354827-ipg1vwmv 211 16 further further JJ cord-354827-ipg1vwmv 211 17 investigation investigation NN cord-354827-ipg1vwmv 211 18 . . . cord-354827-ipg1vwmv 212 1 Once once IN cord-354827-ipg1vwmv 212 2 targets target NNS cord-354827-ipg1vwmv 212 3 have have VBP cord-354827-ipg1vwmv 212 4 been be VBN cord-354827-ipg1vwmv 212 5 identified identify VBN cord-354827-ipg1vwmv 212 6 , , , cord-354827-ipg1vwmv 212 7 the the DT cord-354827-ipg1vwmv 212 8 next next JJ cord-354827-ipg1vwmv 212 9 limiting limit VBG cord-354827-ipg1vwmv 212 10 step step NN cord-354827-ipg1vwmv 212 11 , , , cord-354827-ipg1vwmv 212 12 with with IN cord-354827-ipg1vwmv 212 13 respect respect NN cord-354827-ipg1vwmv 212 14 to to IN cord-354827-ipg1vwmv 212 15 locations location NNS cord-354827-ipg1vwmv 212 16 with with IN cord-354827-ipg1vwmv 212 17 limited limited JJ cord-354827-ipg1vwmv 212 18 resources resource NNS cord-354827-ipg1vwmv 212 19 is be VBZ cord-354827-ipg1vwmv 212 20 developing develop VBG cord-354827-ipg1vwmv 212 21 a a DT cord-354827-ipg1vwmv 212 22 reliable reliable JJ cord-354827-ipg1vwmv 212 23 test test NN cord-354827-ipg1vwmv 212 24 that that WDT cord-354827-ipg1vwmv 212 25 is be VBZ cord-354827-ipg1vwmv 212 26 affordable affordable JJ cord-354827-ipg1vwmv 212 27 . . . cord-354827-ipg1vwmv 213 1 With with IN cord-354827-ipg1vwmv 213 2 the the DT cord-354827-ipg1vwmv 213 3 identification identification NN cord-354827-ipg1vwmv 213 4 of of IN cord-354827-ipg1vwmv 213 5 novel novel JJ cord-354827-ipg1vwmv 213 6 targets target NNS cord-354827-ipg1vwmv 213 7 is be VBZ cord-354827-ipg1vwmv 213 8 should should MD cord-354827-ipg1vwmv 213 9 be be VB cord-354827-ipg1vwmv 213 10 feasible feasible JJ cord-354827-ipg1vwmv 213 11 to to TO cord-354827-ipg1vwmv 213 12 create create VB cord-354827-ipg1vwmv 213 13 simple simple JJ cord-354827-ipg1vwmv 213 14 point point NN cord-354827-ipg1vwmv 213 15 of of IN cord-354827-ipg1vwmv 213 16 care care NN cord-354827-ipg1vwmv 213 17 assays assay NNS cord-354827-ipg1vwmv 213 18 aimed aim VBN cord-354827-ipg1vwmv 213 19 at at IN cord-354827-ipg1vwmv 213 20 these these DT cord-354827-ipg1vwmv 213 21 specific specific JJ cord-354827-ipg1vwmv 213 22 targets target NNS cord-354827-ipg1vwmv 213 23 . . . cord-354827-ipg1vwmv 214 1 However however RB cord-354827-ipg1vwmv 214 2 , , , cord-354827-ipg1vwmv 214 3 making make VBG cord-354827-ipg1vwmv 214 4 such such JJ cord-354827-ipg1vwmv 214 5 tests test NNS cord-354827-ipg1vwmv 214 6 that that WDT cord-354827-ipg1vwmv 214 7 can can MD cord-354827-ipg1vwmv 214 8 be be VB cord-354827-ipg1vwmv 214 9 manufactured manufacture VBN cord-354827-ipg1vwmv 214 10 at at IN cord-354827-ipg1vwmv 214 11 a a DT cord-354827-ipg1vwmv 214 12 reasonable reasonable JJ cord-354827-ipg1vwmv 214 13 cost cost NN cord-354827-ipg1vwmv 214 14 that that WDT cord-354827-ipg1vwmv 214 15 can can MD cord-354827-ipg1vwmv 214 16 aid aid VB cord-354827-ipg1vwmv 214 17 typhoid typhoid NN cord-354827-ipg1vwmv 214 18 diagnostics diagnostic NNS cord-354827-ipg1vwmv 214 19 in in IN cord-354827-ipg1vwmv 214 20 the the DT cord-354827-ipg1vwmv 214 21 locations location NNS cord-354827-ipg1vwmv 214 22 where where WRB cord-354827-ipg1vwmv 214 23 they -PRON- PRP cord-354827-ipg1vwmv 214 24 are be VBP cord-354827-ipg1vwmv 214 25 required require VBN cord-354827-ipg1vwmv 214 26 most most RBS cord-354827-ipg1vwmv 214 27 may may MD cord-354827-ipg1vwmv 214 28 add add VB cord-354827-ipg1vwmv 214 29 an an DT cord-354827-ipg1vwmv 214 30 additional additional JJ cord-354827-ipg1vwmv 214 31 hurdle hurdle NN cord-354827-ipg1vwmv 214 32 . . . cord-354827-ipg1vwmv 215 1 Typhoid typhoid NN cord-354827-ipg1vwmv 215 2 and and CC cord-354827-ipg1vwmv 215 3 paratyphoid paratyphoid NN cord-354827-ipg1vwmv 215 4 fever fever NN cord-354827-ipg1vwmv 216 1 The the DT cord-354827-ipg1vwmv 216 2 global global JJ cord-354827-ipg1vwmv 216 3 burden burden NN cord-354827-ipg1vwmv 216 4 of of IN cord-354827-ipg1vwmv 216 5 typhoid typhoid NN cord-354827-ipg1vwmv 216 6 fever fever NN cord-354827-ipg1vwmv 217 1 Still still RB cord-354827-ipg1vwmv 217 2 an an DT cord-354827-ipg1vwmv 217 3 Enteric Enteric NNP cord-354827-ipg1vwmv 217 4 Fever Fever NNP cord-354827-ipg1vwmv 217 5 Capital Capital NNP cord-354827-ipg1vwmv 217 6 of of IN cord-354827-ipg1vwmv 217 7 the the DT cord-354827-ipg1vwmv 217 8 World World NNP cord-354827-ipg1vwmv 217 9 Typhoid Typhoid NNP cord-354827-ipg1vwmv 217 10 fever fever NN cord-354827-ipg1vwmv 217 11 Antimicrobial Antimicrobial NNP cord-354827-ipg1vwmv 217 12 drug drug NN cord-354827-ipg1vwmv 217 13 resistance resistance NN cord-354827-ipg1vwmv 217 14 of of IN cord-354827-ipg1vwmv 217 15 Salmonella Salmonella NNP cord-354827-ipg1vwmv 217 16 enterica enterica NNP cord-354827-ipg1vwmv 217 17 serovar serovar NNP cord-354827-ipg1vwmv 217 18 typhi typhi NNP cord-354827-ipg1vwmv 217 19 in in IN cord-354827-ipg1vwmv 217 20 asia asia NNP cord-354827-ipg1vwmv 217 21 and and CC cord-354827-ipg1vwmv 217 22 molecular molecular JJ cord-354827-ipg1vwmv 217 23 mechanism mechanism NN cord-354827-ipg1vwmv 217 24 of of IN cord-354827-ipg1vwmv 217 25 reduced reduce VBN cord-354827-ipg1vwmv 217 26 susceptibility susceptibility NN cord-354827-ipg1vwmv 217 27 to to IN cord-354827-ipg1vwmv 217 28 the the DT cord-354827-ipg1vwmv 217 29 fluoroquinolones fluoroquinolone NNS cord-354827-ipg1vwmv 217 30 Typhoid Typhoid NNP cord-354827-ipg1vwmv 217 31 and and CC cord-354827-ipg1vwmv 217 32 paratyphoid paratyphoid NN cord-354827-ipg1vwmv 217 33 fever fever NN cord-354827-ipg1vwmv 217 34 in in IN cord-354827-ipg1vwmv 217 35 travellers traveller NNS cord-354827-ipg1vwmv 217 36 Salmonella Salmonella NNP cord-354827-ipg1vwmv 217 37 paratyphi paratyphi JJ cord-354827-ipg1vwmv 218 1 A a DT cord-354827-ipg1vwmv 218 2 rates rate NNS cord-354827-ipg1vwmv 219 1 Paratyphoid Paratyphoid NNP cord-354827-ipg1vwmv 219 2 fever fever NN cord-354827-ipg1vwmv 219 3 in in IN cord-354827-ipg1vwmv 219 4 India India NNP cord-354827-ipg1vwmv 219 5 : : : cord-354827-ipg1vwmv 220 1 An an DT cord-354827-ipg1vwmv 220 2 emerging emerge VBG cord-354827-ipg1vwmv 220 3 problem problem NN cord-354827-ipg1vwmv 220 4 Emergence Emergence NNP cord-354827-ipg1vwmv 220 5 of of IN cord-354827-ipg1vwmv 220 6 Salmonella Salmonella NNP cord-354827-ipg1vwmv 220 7 enterica enterica NN cord-354827-ipg1vwmv 220 8 serotype serotype NN cord-354827-ipg1vwmv 220 9 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 220 10 A A NNP cord-354827-ipg1vwmv 220 11 as as IN cord-354827-ipg1vwmv 220 12 a a DT cord-354827-ipg1vwmv 220 13 major major JJ cord-354827-ipg1vwmv 220 14 cause cause NN cord-354827-ipg1vwmv 220 15 of of IN cord-354827-ipg1vwmv 220 16 enteric enteric JJ cord-354827-ipg1vwmv 220 17 fever fever NN cord-354827-ipg1vwmv 220 18 in in IN cord-354827-ipg1vwmv 220 19 Kathmandu Kathmandu NNP cord-354827-ipg1vwmv 220 20 WHO who WP cord-354827-ipg1vwmv 220 21 : : : cord-354827-ipg1vwmv 220 22 The the DT cord-354827-ipg1vwmv 220 23 diagnosis diagnosis NN cord-354827-ipg1vwmv 220 24 , , , cord-354827-ipg1vwmv 220 25 treatment treatment NN cord-354827-ipg1vwmv 220 26 and and CC cord-354827-ipg1vwmv 220 27 prevention prevention NN cord-354827-ipg1vwmv 220 28 of of IN cord-354827-ipg1vwmv 220 29 typhoid typhoid NN cord-354827-ipg1vwmv 220 30 fever fever NN cord-354827-ipg1vwmv 220 31 . . . cord-354827-ipg1vwmv 221 1 Communicable communicable JJ cord-354827-ipg1vwmv 221 2 Disease Disease NNP cord-354827-ipg1vwmv 221 3 Surveillance Surveillance NNP cord-354827-ipg1vwmv 221 4 and and CC cord-354827-ipg1vwmv 221 5 Response Response NNP cord-354827-ipg1vwmv 221 6 Vaccine Vaccine NNP cord-354827-ipg1vwmv 221 7 and and CC cord-354827-ipg1vwmv 221 8 Biologicals Biologicals NNP cord-354827-ipg1vwmv 221 9 High high JJ cord-354827-ipg1vwmv 221 10 - - HYPH cord-354827-ipg1vwmv 221 11 throughput throughput NN cord-354827-ipg1vwmv 221 12 sequencing sequencing NN cord-354827-ipg1vwmv 221 13 provides provide VBZ cord-354827-ipg1vwmv 221 14 insights insight NNS cord-354827-ipg1vwmv 221 15 into into IN cord-354827-ipg1vwmv 221 16 genome genome NN cord-354827-ipg1vwmv 221 17 variation variation NN cord-354827-ipg1vwmv 221 18 and and CC cord-354827-ipg1vwmv 221 19 evolution evolution NN cord-354827-ipg1vwmv 221 20 in in IN cord-354827-ipg1vwmv 221 21 Salmonella Salmonella NNP cord-354827-ipg1vwmv 221 22 Typhi Typhi NNP cord-354827-ipg1vwmv 221 23 Comparison Comparison NNP cord-354827-ipg1vwmv 221 24 of of IN cord-354827-ipg1vwmv 221 25 genome genome NN cord-354827-ipg1vwmv 221 26 degradation degradation NN cord-354827-ipg1vwmv 221 27 in in IN cord-354827-ipg1vwmv 221 28 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 221 29 A A NNP cord-354827-ipg1vwmv 221 30 and and CC cord-354827-ipg1vwmv 221 31 Typhi Typhi NNP cord-354827-ipg1vwmv 221 32 , , , cord-354827-ipg1vwmv 221 33 human human NN cord-354827-ipg1vwmv 221 34 - - HYPH cord-354827-ipg1vwmv 221 35 restricted restrict VBN cord-354827-ipg1vwmv 221 36 serovars serovar NNS cord-354827-ipg1vwmv 221 37 of of IN cord-354827-ipg1vwmv 221 38 Salmonella Salmonella NNP cord-354827-ipg1vwmv 221 39 enterica enterica NNP cord-354827-ipg1vwmv 221 40 that that WDT cord-354827-ipg1vwmv 221 41 cause cause VBP cord-354827-ipg1vwmv 221 42 typhoid typhoid NN cord-354827-ipg1vwmv 221 43 Complete complete JJ cord-354827-ipg1vwmv 221 44 genome genome NN cord-354827-ipg1vwmv 221 45 sequence sequence NN cord-354827-ipg1vwmv 221 46 of of IN cord-354827-ipg1vwmv 221 47 a a DT cord-354827-ipg1vwmv 221 48 multiple multiple JJ cord-354827-ipg1vwmv 221 49 drug drug NN cord-354827-ipg1vwmv 221 50 resistant resistant JJ cord-354827-ipg1vwmv 221 51 Salmonella Salmonella NNP cord-354827-ipg1vwmv 221 52 enterica enterica NN cord-354827-ipg1vwmv 222 1 serovar serovar NNP cord-354827-ipg1vwmv 222 2 Typhi Typhi NNP cord-354827-ipg1vwmv 222 3 CT18 CT18 NNP cord-354827-ipg1vwmv 222 4 Evolutionary Evolutionary NNP cord-354827-ipg1vwmv 222 5 history history NN cord-354827-ipg1vwmv 222 6 of of IN cord-354827-ipg1vwmv 222 7 Salmonella Salmonella NNP cord-354827-ipg1vwmv 222 8 typhi typhi NNS cord-354827-ipg1vwmv 222 9 Cloning cloning NN cord-354827-ipg1vwmv 222 10 and and CC cord-354827-ipg1vwmv 222 11 molecular molecular JJ cord-354827-ipg1vwmv 222 12 characterization characterization NN cord-354827-ipg1vwmv 222 13 of of IN cord-354827-ipg1vwmv 222 14 genes gene NNS cord-354827-ipg1vwmv 222 15 whose whose WP$ cord-354827-ipg1vwmv 222 16 products product NNS cord-354827-ipg1vwmv 222 17 allow allow VBP cord-354827-ipg1vwmv 222 18 Salmonella salmonella NN cord-354827-ipg1vwmv 222 19 typhimurium typhimurium NN cord-354827-ipg1vwmv 222 20 to to TO cord-354827-ipg1vwmv 222 21 penetrate penetrate VB cord-354827-ipg1vwmv 222 22 tissue tissue NN cord-354827-ipg1vwmv 222 23 culture culture NN cord-354827-ipg1vwmv 222 24 cells cell NNS cord-354827-ipg1vwmv 222 25 Entry entry NN cord-354827-ipg1vwmv 222 26 of of IN cord-354827-ipg1vwmv 222 27 microbes microbe NNS cord-354827-ipg1vwmv 222 28 into into IN cord-354827-ipg1vwmv 222 29 the the DT cord-354827-ipg1vwmv 222 30 host host NN cord-354827-ipg1vwmv 223 1 : : : cord-354827-ipg1vwmv 223 2 using use VBG cord-354827-ipg1vwmv 223 3 M M NNP cord-354827-ipg1vwmv 223 4 cells cell NNS cord-354827-ipg1vwmv 223 5 to to TO cord-354827-ipg1vwmv 223 6 break break VB cord-354827-ipg1vwmv 223 7 the the DT cord-354827-ipg1vwmv 223 8 mucosal mucosal JJ cord-354827-ipg1vwmv 223 9 barrier barrier NN cord-354827-ipg1vwmv 223 10 Pseudogene Pseudogene NNP cord-354827-ipg1vwmv 223 11 accumulation accumulation NN cord-354827-ipg1vwmv 223 12 in in IN cord-354827-ipg1vwmv 223 13 the the DT cord-354827-ipg1vwmv 223 14 evolutionary evolutionary JJ cord-354827-ipg1vwmv 223 15 histories history NNS cord-354827-ipg1vwmv 223 16 of of IN cord-354827-ipg1vwmv 223 17 Salmonella Salmonella NNP cord-354827-ipg1vwmv 223 18 enterica enterica NNP cord-354827-ipg1vwmv 223 19 serovars serovar NNS cord-354827-ipg1vwmv 224 1 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 224 2 A A NNP cord-354827-ipg1vwmv 224 3 and and CC cord-354827-ipg1vwmv 224 4 Typhi Typhi NNP cord-354827-ipg1vwmv 224 5 The the DT cord-354827-ipg1vwmv 224 6 Vi Vi NNP cord-354827-ipg1vwmv 224 7 capsular capsular NN cord-354827-ipg1vwmv 224 8 antigen antigen NN cord-354827-ipg1vwmv 224 9 of of IN cord-354827-ipg1vwmv 224 10 Salmonella Salmonella NNP cord-354827-ipg1vwmv 224 11 enterica enterica NN cord-354827-ipg1vwmv 224 12 serotype serotype NN cord-354827-ipg1vwmv 224 13 Typhi Typhi NNP cord-354827-ipg1vwmv 224 14 reduces reduce VBZ cord-354827-ipg1vwmv 224 15 Toll Toll NNP cord-354827-ipg1vwmv 224 16 - - HYPH cord-354827-ipg1vwmv 224 17 like like JJ cord-354827-ipg1vwmv 224 18 receptor receptor NN cord-354827-ipg1vwmv 224 19 - - HYPH cord-354827-ipg1vwmv 224 20 dependent dependent JJ cord-354827-ipg1vwmv 224 21 interleukin-8 interleukin-8 JJ cord-354827-ipg1vwmv 224 22 expression expression NN cord-354827-ipg1vwmv 224 23 in in IN cord-354827-ipg1vwmv 224 24 the the DT cord-354827-ipg1vwmv 224 25 intestinal intestinal JJ cord-354827-ipg1vwmv 224 26 mucosa mucosa JJ cord-354827-ipg1vwmv 224 27 Capsulemediated Capsulemediated NNP cord-354827-ipg1vwmv 224 28 immune immune JJ cord-354827-ipg1vwmv 224 29 evasion evasion NN cord-354827-ipg1vwmv 224 30 : : : cord-354827-ipg1vwmv 224 31 a a DT cord-354827-ipg1vwmv 224 32 new new JJ cord-354827-ipg1vwmv 224 33 hypothesis hypothesis NN cord-354827-ipg1vwmv 224 34 explaining explain VBG cord-354827-ipg1vwmv 224 35 aspects aspect NNS cord-354827-ipg1vwmv 224 36 of of IN cord-354827-ipg1vwmv 224 37 typhoid typhoid NN cord-354827-ipg1vwmv 224 38 fever fever NN cord-354827-ipg1vwmv 224 39 pathogenesis pathogenesis NN cord-354827-ipg1vwmv 224 40 Quantitation Quantitation NNP cord-354827-ipg1vwmv 224 41 of of IN cord-354827-ipg1vwmv 224 42 bacteria bacteria NNS cord-354827-ipg1vwmv 224 43 in in IN cord-354827-ipg1vwmv 224 44 blood blood NN cord-354827-ipg1vwmv 224 45 of of IN cord-354827-ipg1vwmv 224 46 typhoid typhoid NN cord-354827-ipg1vwmv 224 47 fever fever NN cord-354827-ipg1vwmv 224 48 patients patient NNS cord-354827-ipg1vwmv 224 49 and and CC cord-354827-ipg1vwmv 224 50 relationship relationship NN cord-354827-ipg1vwmv 224 51 between between IN cord-354827-ipg1vwmv 224 52 counts count NNS cord-354827-ipg1vwmv 224 53 and and CC cord-354827-ipg1vwmv 224 54 clinical clinical JJ cord-354827-ipg1vwmv 224 55 features feature NNS cord-354827-ipg1vwmv 224 56 , , , cord-354827-ipg1vwmv 224 57 transmissibility transmissibility NN cord-354827-ipg1vwmv 224 58 , , , cord-354827-ipg1vwmv 224 59 and and CC cord-354827-ipg1vwmv 224 60 antibiotic antibiotic JJ cord-354827-ipg1vwmv 224 61 resistance resistance NN cord-354827-ipg1vwmv 224 62 Quantitation Quantitation NNP cord-354827-ipg1vwmv 224 63 of of IN cord-354827-ipg1vwmv 224 64 bacteria bacteria NNS cord-354827-ipg1vwmv 224 65 in in IN cord-354827-ipg1vwmv 224 66 bone bone NN cord-354827-ipg1vwmv 224 67 marrow marrow NN cord-354827-ipg1vwmv 224 68 from from IN cord-354827-ipg1vwmv 224 69 patients patient NNS cord-354827-ipg1vwmv 224 70 with with IN cord-354827-ipg1vwmv 224 71 typhoid typhoid NN cord-354827-ipg1vwmv 224 72 fever fever NN cord-354827-ipg1vwmv 224 73 : : : cord-354827-ipg1vwmv 224 74 relationship relationship NN cord-354827-ipg1vwmv 224 75 between between IN cord-354827-ipg1vwmv 224 76 counts count NNS cord-354827-ipg1vwmv 224 77 and and CC cord-354827-ipg1vwmv 224 78 clinical clinical JJ cord-354827-ipg1vwmv 224 79 features feature NNS cord-354827-ipg1vwmv 224 80 Safety Safety NNP cord-354827-ipg1vwmv 224 81 of of IN cord-354827-ipg1vwmv 224 82 live live JJ cord-354827-ipg1vwmv 224 83 oral oral JJ cord-354827-ipg1vwmv 224 84 Salmonella Salmonella NNP cord-354827-ipg1vwmv 224 85 typhi typhi NNP cord-354827-ipg1vwmv 224 86 vaccine vaccine NN cord-354827-ipg1vwmv 224 87 strains strain VBZ cord-354827-ipg1vwmv 224 88 with with IN cord-354827-ipg1vwmv 224 89 deletions deletion NNS cord-354827-ipg1vwmv 224 90 in in IN cord-354827-ipg1vwmv 224 91 htrA htra JJ cord-354827-ipg1vwmv 224 92 and and CC cord-354827-ipg1vwmv 224 93 aroC aroC NNP cord-354827-ipg1vwmv 224 94 aroD aroD NNS cord-354827-ipg1vwmv 224 95 and and CC cord-354827-ipg1vwmv 224 96 immune immune JJ cord-354827-ipg1vwmv 224 97 response response NN cord-354827-ipg1vwmv 224 98 in in IN cord-354827-ipg1vwmv 224 99 humans human NNS cord-354827-ipg1vwmv 224 100 Volunteer Volunteer NNP cord-354827-ipg1vwmv 224 101 studies study NNS cord-354827-ipg1vwmv 224 102 of of IN cord-354827-ipg1vwmv 224 103 typhoid typhoid NN cord-354827-ipg1vwmv 224 104 fever fever NN cord-354827-ipg1vwmv 224 105 and and CC cord-354827-ipg1vwmv 224 106 vaccines vaccine NNS cord-354827-ipg1vwmv 225 1 Molecular molecular JJ cord-354827-ipg1vwmv 225 2 typing typing NN cord-354827-ipg1vwmv 225 3 of of IN cord-354827-ipg1vwmv 225 4 multiple multiple JJ cord-354827-ipg1vwmv 225 5 - - HYPH cord-354827-ipg1vwmv 225 6 antibioticresistant antibioticresistant JJ cord-354827-ipg1vwmv 225 7 Salmonella Salmonella NNP cord-354827-ipg1vwmv 225 8 enterica enterica NNP cord-354827-ipg1vwmv 225 9 serovar serovar NNP cord-354827-ipg1vwmv 225 10 Typhi Typhi NNP cord-354827-ipg1vwmv 225 11 from from IN cord-354827-ipg1vwmv 225 12 Vietnam Vietnam NNP cord-354827-ipg1vwmv 225 13 : : : cord-354827-ipg1vwmv 225 14 application application NN cord-354827-ipg1vwmv 225 15 to to IN cord-354827-ipg1vwmv 225 16 acute acute JJ cord-354827-ipg1vwmv 225 17 and and CC cord-354827-ipg1vwmv 225 18 relapse relapse NN cord-354827-ipg1vwmv 225 19 cases case NNS cord-354827-ipg1vwmv 225 20 of of IN cord-354827-ipg1vwmv 225 21 typhoid typhoid NN cord-354827-ipg1vwmv 225 22 fever fever NN cord-354827-ipg1vwmv 225 23 Serology serology NN cord-354827-ipg1vwmv 225 24 of of IN cord-354827-ipg1vwmv 225 25 typhoid typhoid NN cord-354827-ipg1vwmv 225 26 fever fever NN cord-354827-ipg1vwmv 225 27 in in IN cord-354827-ipg1vwmv 225 28 an an DT cord-354827-ipg1vwmv 225 29 area area NN cord-354827-ipg1vwmv 225 30 of of IN cord-354827-ipg1vwmv 225 31 endemicity endemicity NN cord-354827-ipg1vwmv 225 32 and and CC cord-354827-ipg1vwmv 225 33 its -PRON- PRP$ cord-354827-ipg1vwmv 225 34 relevance relevance NN cord-354827-ipg1vwmv 225 35 to to IN cord-354827-ipg1vwmv 225 36 diagnosis diagnosis NN cord-354827-ipg1vwmv 225 37 Murine murine IN cord-354827-ipg1vwmv 225 38 typhus typhus NN cord-354827-ipg1vwmv 225 39 and and CC cord-354827-ipg1vwmv 225 40 febrile febrile JJ cord-354827-ipg1vwmv 225 41 illness illness NN cord-354827-ipg1vwmv 226 1 The the DT cord-354827-ipg1vwmv 226 2 etiology etiology NN cord-354827-ipg1vwmv 226 3 of of IN cord-354827-ipg1vwmv 226 4 febrile febrile JJ cord-354827-ipg1vwmv 226 5 illness illness NN cord-354827-ipg1vwmv 226 6 in in IN cord-354827-ipg1vwmv 226 7 adults adult NNS cord-354827-ipg1vwmv 226 8 presenting present VBG cord-354827-ipg1vwmv 226 9 to to IN cord-354827-ipg1vwmv 226 10 Patan Patan NNP cord-354827-ipg1vwmv 226 11 hospital hospital NN cord-354827-ipg1vwmv 226 12 in in IN cord-354827-ipg1vwmv 226 13 Kathmandu Kathmandu NNP cord-354827-ipg1vwmv 226 14 , , , cord-354827-ipg1vwmv 226 15 Nepal Nepal NNP cord-354827-ipg1vwmv 226 16 Relative Relative NNP cord-354827-ipg1vwmv 226 17 efficacy efficacy NN cord-354827-ipg1vwmv 226 18 of of IN cord-354827-ipg1vwmv 226 19 blood blood NN cord-354827-ipg1vwmv 226 20 , , , cord-354827-ipg1vwmv 226 21 urine urine NN cord-354827-ipg1vwmv 226 22 , , , cord-354827-ipg1vwmv 226 23 rectal rectal JJ cord-354827-ipg1vwmv 226 24 swab swab NN cord-354827-ipg1vwmv 226 25 , , , cord-354827-ipg1vwmv 226 26 bone bone NN cord-354827-ipg1vwmv 226 27 - - HYPH cord-354827-ipg1vwmv 226 28 marrow marrow NN cord-354827-ipg1vwmv 226 29 , , , cord-354827-ipg1vwmv 226 30 and and CC cord-354827-ipg1vwmv 226 31 rosespot rosespot NN cord-354827-ipg1vwmv 226 32 cultures culture NNS cord-354827-ipg1vwmv 226 33 for for IN cord-354827-ipg1vwmv 226 34 recovery recovery NN cord-354827-ipg1vwmv 226 35 of of IN cord-354827-ipg1vwmv 226 36 Salmonella Salmonella NNP cord-354827-ipg1vwmv 226 37 typhi typhi NNS cord-354827-ipg1vwmv 226 38 in in IN cord-354827-ipg1vwmv 226 39 typhoid typhoid NN cord-354827-ipg1vwmv 226 40 fever fever NN cord-354827-ipg1vwmv 226 41 Value Value NNP cord-354827-ipg1vwmv 226 42 of of IN cord-354827-ipg1vwmv 226 43 a a DT cord-354827-ipg1vwmv 226 44 single single JJ cord-354827-ipg1vwmv 226 45 - - HYPH cord-354827-ipg1vwmv 226 46 tube tube NN cord-354827-ipg1vwmv 226 47 widal widal JJ cord-354827-ipg1vwmv 226 48 test test NN cord-354827-ipg1vwmv 226 49 in in IN cord-354827-ipg1vwmv 226 50 diagnosis diagnosis NN cord-354827-ipg1vwmv 226 51 of of IN cord-354827-ipg1vwmv 226 52 typhoid typhoid NN cord-354827-ipg1vwmv 226 53 fever fever NN cord-354827-ipg1vwmv 226 54 in in IN cord-354827-ipg1vwmv 226 55 Vietnam Vietnam NNP cord-354827-ipg1vwmv 226 56 High high JJ cord-354827-ipg1vwmv 226 57 - - HYPH cord-354827-ipg1vwmv 226 58 throughput throughput NN cord-354827-ipg1vwmv 226 59 genotyping genotyping NN cord-354827-ipg1vwmv 226 60 of of IN cord-354827-ipg1vwmv 226 61 Salmonella Salmonella NNP cord-354827-ipg1vwmv 226 62 enterica enterica NNP cord-354827-ipg1vwmv 227 1 serovar serovar NNP cord-354827-ipg1vwmv 227 2 Typhi Typhi NNP cord-354827-ipg1vwmv 227 3 allowing allow VBG cord-354827-ipg1vwmv 227 4 geographical geographical JJ cord-354827-ipg1vwmv 227 5 assignment assignment NN cord-354827-ipg1vwmv 227 6 of of IN cord-354827-ipg1vwmv 227 7 haplotypes haplotype NNS cord-354827-ipg1vwmv 227 8 and and CC cord-354827-ipg1vwmv 227 9 pathotypes pathotype NNS cord-354827-ipg1vwmv 227 10 within within IN cord-354827-ipg1vwmv 227 11 an an DT cord-354827-ipg1vwmv 227 12 urban urban JJ cord-354827-ipg1vwmv 227 13 District District NNP cord-354827-ipg1vwmv 227 14 of of IN cord-354827-ipg1vwmv 227 15 Jakarta Jakarta NNP cord-354827-ipg1vwmv 227 16 , , , cord-354827-ipg1vwmv 227 17 Indonesia Indonesia NNP cord-354827-ipg1vwmv 228 1 A a DT cord-354827-ipg1vwmv 228 2 novel novel JJ cord-354827-ipg1vwmv 228 3 linear linear JJ cord-354827-ipg1vwmv 228 4 plasmid plasmid NN cord-354827-ipg1vwmv 228 5 mediates mediate VBZ cord-354827-ipg1vwmv 228 6 flagellar flagellar JJ cord-354827-ipg1vwmv 228 7 variation variation NN cord-354827-ipg1vwmv 228 8 in in IN cord-354827-ipg1vwmv 228 9 Salmonella Salmonella NNP cord-354827-ipg1vwmv 228 10 Typhi Typhi NNP cord-354827-ipg1vwmv 228 11 Mono Mono NNP cord-354827-ipg1vwmv 228 12 - - HYPH cord-354827-ipg1vwmv 228 13 and and CC cord-354827-ipg1vwmv 228 14 bi bi JJ cord-354827-ipg1vwmv 228 15 - - JJ cord-354827-ipg1vwmv 228 16 phasic phasic JJ cord-354827-ipg1vwmv 228 17 Salmonella Salmonella NNP cord-354827-ipg1vwmv 228 18 typhi typhi NNS cord-354827-ipg1vwmv 228 19 : : : cord-354827-ipg1vwmv 228 20 genetic genetic JJ cord-354827-ipg1vwmv 228 21 homogeneity homogeneity NN cord-354827-ipg1vwmv 228 22 and and CC cord-354827-ipg1vwmv 228 23 distinguishing distinguish VBG cord-354827-ipg1vwmv 228 24 characteristics characteristic NNS cord-354827-ipg1vwmv 229 1 Unique unique JJ cord-354827-ipg1vwmv 229 2 sequences sequence NNS cord-354827-ipg1vwmv 229 3 in in IN cord-354827-ipg1vwmv 229 4 region region NN cord-354827-ipg1vwmv 229 5 VI VI NNP cord-354827-ipg1vwmv 229 6 of of IN cord-354827-ipg1vwmv 229 7 the the DT cord-354827-ipg1vwmv 229 8 flagellin flagellin JJ cord-354827-ipg1vwmv 229 9 gene gene NN cord-354827-ipg1vwmv 229 10 of of IN cord-354827-ipg1vwmv 229 11 Salmonella Salmonella NNP cord-354827-ipg1vwmv 229 12 typhi typhi NNP cord-354827-ipg1vwmv 229 13 Detection Detection NNP cord-354827-ipg1vwmv 229 14 of of IN cord-354827-ipg1vwmv 229 15 Vi Vi NNP cord-354827-ipg1vwmv 229 16 - - HYPH cord-354827-ipg1vwmv 229 17 negative negative JJ cord-354827-ipg1vwmv 229 18 Salmonella Salmonella NNP cord-354827-ipg1vwmv 229 19 enterica enterica NN cord-354827-ipg1vwmv 230 1 serovar serovar NNP cord-354827-ipg1vwmv 230 2 typhi typhi NNP cord-354827-ipg1vwmv 230 3 in in IN cord-354827-ipg1vwmv 230 4 the the DT cord-354827-ipg1vwmv 230 5 Baker Baker NNP cord-354827-ipg1vwmv 230 6 et et NNP cord-354827-ipg1vwmv 230 7 al al NNP cord-354827-ipg1vwmv 230 8 . . . cord-354827-ipg1vwmv 231 1 BMC BMC NNP cord-354827-ipg1vwmv 231 2 Infectious Infectious NNP cord-354827-ipg1vwmv 231 3 Diseases Diseases NNPS cord-354827-ipg1vwmv 231 4 peripheral peripheral JJ cord-354827-ipg1vwmv 231 5 blood blood NN cord-354827-ipg1vwmv 231 6 of of IN cord-354827-ipg1vwmv 231 7 patients patient NNS cord-354827-ipg1vwmv 231 8 with with IN cord-354827-ipg1vwmv 231 9 typhoid typhoid NN cord-354827-ipg1vwmv 231 10 fever fever NN cord-354827-ipg1vwmv 231 11 in in IN cord-354827-ipg1vwmv 231 12 the the DT cord-354827-ipg1vwmv 231 13 Faisalabad Faisalabad NNP cord-354827-ipg1vwmv 231 14 region region NN cord-354827-ipg1vwmv 231 15 of of IN cord-354827-ipg1vwmv 231 16 Pakistan Pakistan NNP cord-354827-ipg1vwmv 231 17 Vi Vi NNP cord-354827-ipg1vwmv 231 18 antigen antigen NN cord-354827-ipg1vwmv 231 19 expression expression NN cord-354827-ipg1vwmv 231 20 in in IN cord-354827-ipg1vwmv 231 21 Salmonella Salmonella NNP cord-354827-ipg1vwmv 231 22 enterica enterica NNP cord-354827-ipg1vwmv 232 1 serovar serovar NNP cord-354827-ipg1vwmv 233 1 Typhi Typhi NNP cord-354827-ipg1vwmv 233 2 clinical clinical JJ cord-354827-ipg1vwmv 233 3 isolates isolate NNS cord-354827-ipg1vwmv 233 4 from from IN cord-354827-ipg1vwmv 233 5 Pakistan Pakistan NNP cord-354827-ipg1vwmv 233 6 Use Use NNP cord-354827-ipg1vwmv 233 7 of of IN cord-354827-ipg1vwmv 233 8 paired paired JJ cord-354827-ipg1vwmv 233 9 serum serum NN cord-354827-ipg1vwmv 233 10 samples sample NNS cord-354827-ipg1vwmv 233 11 for for IN cord-354827-ipg1vwmv 233 12 serodiagnosis serodiagnosis NN cord-354827-ipg1vwmv 233 13 of of IN cord-354827-ipg1vwmv 233 14 typhoid typhoid NNP cord-354827-ipg1vwmv 233 15 fever fever NNP cord-354827-ipg1vwmv 233 16 One one CD cord-354827-ipg1vwmv 233 17 - - HYPH cord-354827-ipg1vwmv 233 18 step step NN cord-354827-ipg1vwmv 233 19 2-minute 2-minute NN cord-354827-ipg1vwmv 233 20 test test NN cord-354827-ipg1vwmv 233 21 to to TO cord-354827-ipg1vwmv 233 22 detect detect VB cord-354827-ipg1vwmv 233 23 typhoid typhoid NN cord-354827-ipg1vwmv 233 24 - - HYPH cord-354827-ipg1vwmv 233 25 specific specific JJ cord-354827-ipg1vwmv 233 26 antibodies antibody NNS cord-354827-ipg1vwmv 233 27 based base VBN cord-354827-ipg1vwmv 233 28 on on IN cord-354827-ipg1vwmv 233 29 particle particle NN cord-354827-ipg1vwmv 233 30 separation separation NN cord-354827-ipg1vwmv 233 31 in in IN cord-354827-ipg1vwmv 233 32 tubes tube NNS cord-354827-ipg1vwmv 233 33 Dot dot NN cord-354827-ipg1vwmv 233 34 enzyme enzyme NN cord-354827-ipg1vwmv 233 35 immunoassay immunoassay NN cord-354827-ipg1vwmv 233 36 ( ( -LRB- cord-354827-ipg1vwmv 233 37 Typhidot Typhidot NNP cord-354827-ipg1vwmv 233 38 ) ) -RRB- cord-354827-ipg1vwmv 233 39 in in IN cord-354827-ipg1vwmv 233 40 diagnosis diagnosis NN cord-354827-ipg1vwmv 233 41 of of IN cord-354827-ipg1vwmv 233 42 typhoid typhoid NN cord-354827-ipg1vwmv 233 43 fever fever NN cord-354827-ipg1vwmv 233 44 in in IN cord-354827-ipg1vwmv 233 45 children child NNS cord-354827-ipg1vwmv 233 46 Evaluation Evaluation NNP cord-354827-ipg1vwmv 233 47 of of IN cord-354827-ipg1vwmv 233 48 new new JJ cord-354827-ipg1vwmv 233 49 - - HYPH cord-354827-ipg1vwmv 233 50 generation generation NN cord-354827-ipg1vwmv 233 51 serologic serologic NNP cord-354827-ipg1vwmv 233 52 tests test NNS cord-354827-ipg1vwmv 233 53 for for IN cord-354827-ipg1vwmv 233 54 the the DT cord-354827-ipg1vwmv 233 55 diagnosis diagnosis NN cord-354827-ipg1vwmv 233 56 of of IN cord-354827-ipg1vwmv 233 57 typhoid typhoid NN cord-354827-ipg1vwmv 233 58 fever fever NN cord-354827-ipg1vwmv 233 59 : : : cord-354827-ipg1vwmv 233 60 data datum NNS cord-354827-ipg1vwmv 233 61 from from IN cord-354827-ipg1vwmv 233 62 a a DT cord-354827-ipg1vwmv 233 63 community community NN cord-354827-ipg1vwmv 233 64 - - HYPH cord-354827-ipg1vwmv 233 65 based base VBN cord-354827-ipg1vwmv 233 66 surveillance surveillance NN cord-354827-ipg1vwmv 233 67 in in IN cord-354827-ipg1vwmv 233 68 Calcutta Calcutta NNP cord-354827-ipg1vwmv 234 1 A a DT cord-354827-ipg1vwmv 234 2 study study NN cord-354827-ipg1vwmv 234 3 of of IN cord-354827-ipg1vwmv 234 4 typhoid typhoid NN cord-354827-ipg1vwmv 234 5 fever fever NN cord-354827-ipg1vwmv 234 6 in in IN cord-354827-ipg1vwmv 234 7 five five CD cord-354827-ipg1vwmv 234 8 Asian asian JJ cord-354827-ipg1vwmv 234 9 countries country NNS cord-354827-ipg1vwmv 234 10 : : : cord-354827-ipg1vwmv 234 11 disease disease NN cord-354827-ipg1vwmv 234 12 burden burden NN cord-354827-ipg1vwmv 234 13 and and CC cord-354827-ipg1vwmv 234 14 implications implication NNS cord-354827-ipg1vwmv 234 15 for for IN cord-354827-ipg1vwmv 234 16 controls control NNS cord-354827-ipg1vwmv 235 1 A a DT cord-354827-ipg1vwmv 235 2 genome genome NN cord-354827-ipg1vwmv 235 3 - - HYPH cord-354827-ipg1vwmv 235 4 wide wide JJ cord-354827-ipg1vwmv 235 5 proteome proteome NN cord-354827-ipg1vwmv 235 6 array array NN cord-354827-ipg1vwmv 235 7 reveals reveal VBZ cord-354827-ipg1vwmv 235 8 a a DT cord-354827-ipg1vwmv 235 9 limited limited JJ cord-354827-ipg1vwmv 235 10 set set NN cord-354827-ipg1vwmv 235 11 of of IN cord-354827-ipg1vwmv 235 12 immunogens immunogen NNS cord-354827-ipg1vwmv 235 13 in in IN cord-354827-ipg1vwmv 235 14 natural natural JJ cord-354827-ipg1vwmv 235 15 infections infection NNS cord-354827-ipg1vwmv 235 16 of of IN cord-354827-ipg1vwmv 235 17 humans human NNS cord-354827-ipg1vwmv 235 18 and and CC cord-354827-ipg1vwmv 235 19 white white JJ cord-354827-ipg1vwmv 235 20 - - HYPH cord-354827-ipg1vwmv 235 21 footed footed JJ cord-354827-ipg1vwmv 235 22 mice mouse NNS cord-354827-ipg1vwmv 235 23 with with IN cord-354827-ipg1vwmv 235 24 Borrelia Borrelia NNP cord-354827-ipg1vwmv 235 25 burgdorferi burgdorferi NN cord-354827-ipg1vwmv 235 26 Multiplex Multiplex NNP cord-354827-ipg1vwmv 235 27 PCR PCR NNP cord-354827-ipg1vwmv 235 28 for for IN cord-354827-ipg1vwmv 235 29 differential differential JJ cord-354827-ipg1vwmv 235 30 diagnosis diagnosis NN cord-354827-ipg1vwmv 235 31 of of IN cord-354827-ipg1vwmv 235 32 emerging emerge VBG cord-354827-ipg1vwmv 235 33 typhoidal typhoidal JJ cord-354827-ipg1vwmv 235 34 pathogens pathogen NNS cord-354827-ipg1vwmv 235 35 directly directly RB cord-354827-ipg1vwmv 235 36 from from IN cord-354827-ipg1vwmv 235 37 blood blood NN cord-354827-ipg1vwmv 235 38 samples sample NNS cord-354827-ipg1vwmv 235 39 Development Development NNP cord-354827-ipg1vwmv 235 40 of of IN cord-354827-ipg1vwmv 235 41 an an DT cord-354827-ipg1vwmv 235 42 ultra ultra JJ cord-354827-ipg1vwmv 235 43 rapid rapid JJ cord-354827-ipg1vwmv 235 44 and and CC cord-354827-ipg1vwmv 235 45 simple simple JJ cord-354827-ipg1vwmv 235 46 multiplex multiplex NN cord-354827-ipg1vwmv 235 47 polymerase polymerase NN cord-354827-ipg1vwmv 235 48 chain chain NN cord-354827-ipg1vwmv 235 49 reaction reaction NN cord-354827-ipg1vwmv 235 50 technique technique NN cord-354827-ipg1vwmv 235 51 for for IN cord-354827-ipg1vwmv 235 52 detection detection NN cord-354827-ipg1vwmv 235 53 of of IN cord-354827-ipg1vwmv 235 54 Salmonella Salmonella NNP cord-354827-ipg1vwmv 235 55 typhi typhi NNP cord-354827-ipg1vwmv 235 56 PCR PCR NNP cord-354827-ipg1vwmv 235 57 method method NN cord-354827-ipg1vwmv 235 58 to to TO cord-354827-ipg1vwmv 235 59 identify identify VB cord-354827-ipg1vwmv 235 60 Salmonella Salmonella NNP cord-354827-ipg1vwmv 235 61 enterica enterica NNP cord-354827-ipg1vwmv 235 62 serovars serovars NNP cord-354827-ipg1vwmv 235 63 Typhi Typhi NNP cord-354827-ipg1vwmv 235 64 , , , cord-354827-ipg1vwmv 235 65 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 235 66 A A NNP cord-354827-ipg1vwmv 235 67 , , , cord-354827-ipg1vwmv 235 68 and and CC cord-354827-ipg1vwmv 235 69 Paratyphi Paratyphi NNP cord-354827-ipg1vwmv 235 70 B B NNP cord-354827-ipg1vwmv 235 71 among among IN cord-354827-ipg1vwmv 235 72 Salmonella Salmonella NNP cord-354827-ipg1vwmv 235 73 Isolates Isolates NNPS cord-354827-ipg1vwmv 235 74 from from IN cord-354827-ipg1vwmv 235 75 the the DT cord-354827-ipg1vwmv 235 76 blood blood NN cord-354827-ipg1vwmv 235 77 of of IN cord-354827-ipg1vwmv 235 78 patients patient NNS cord-354827-ipg1vwmv 235 79 with with IN cord-354827-ipg1vwmv 235 80 clinical clinical JJ cord-354827-ipg1vwmv 235 81 enteric enteric JJ cord-354827-ipg1vwmv 235 82 fever fever NN cord-354827-ipg1vwmv 235 83 Rapid rapid JJ cord-354827-ipg1vwmv 235 84 diagnosis diagnosis NN cord-354827-ipg1vwmv 235 85 of of IN cord-354827-ipg1vwmv 235 86 typhoid typhoid NN cord-354827-ipg1vwmv 235 87 fever fever NN cord-354827-ipg1vwmv 235 88 by by IN cord-354827-ipg1vwmv 235 89 PCR PCR NNP cord-354827-ipg1vwmv 235 90 assay assay NN cord-354827-ipg1vwmv 235 91 using use VBG cord-354827-ipg1vwmv 235 92 one one CD cord-354827-ipg1vwmv 235 93 pair pair NN cord-354827-ipg1vwmv 235 94 of of IN cord-354827-ipg1vwmv 235 95 primers primer NNS cord-354827-ipg1vwmv 235 96 from from IN cord-354827-ipg1vwmv 235 97 flagellin flagellin JJ cord-354827-ipg1vwmv 235 98 gene gene NN cord-354827-ipg1vwmv 235 99 of of IN cord-354827-ipg1vwmv 235 100 Salmonella Salmonella NNP cord-354827-ipg1vwmv 235 101 typhi typhi NNP cord-354827-ipg1vwmv 235 102 Diagnosis Diagnosis NNP cord-354827-ipg1vwmv 235 103 of of IN cord-354827-ipg1vwmv 235 104 typhoid typhoid NN cord-354827-ipg1vwmv 235 105 fever fever NN cord-354827-ipg1vwmv 235 106 by by IN cord-354827-ipg1vwmv 235 107 polymerase polymerase NN cord-354827-ipg1vwmv 235 108 chain chain NN cord-354827-ipg1vwmv 235 109 reaction reaction NN cord-354827-ipg1vwmv 235 110 Quantitative quantitative JJ cord-354827-ipg1vwmv 235 111 detection detection NN cord-354827-ipg1vwmv 235 112 of of IN cord-354827-ipg1vwmv 235 113 Salmonella Salmonella NNP cord-354827-ipg1vwmv 235 114 enterica enterica NNP cord-354827-ipg1vwmv 235 115 serovar serovar NNP cord-354827-ipg1vwmv 235 116 Typhi Typhi NNP cord-354827-ipg1vwmv 235 117 from from IN cord-354827-ipg1vwmv 235 118 blood blood NN cord-354827-ipg1vwmv 235 119 of of IN cord-354827-ipg1vwmv 235 120 suspected suspect VBN cord-354827-ipg1vwmv 235 121 typhoid typhoid NN cord-354827-ipg1vwmv 235 122 fever fever NN cord-354827-ipg1vwmv 235 123 patients patient NNS cord-354827-ipg1vwmv 235 124 by by IN cord-354827-ipg1vwmv 235 125 real real JJ cord-354827-ipg1vwmv 235 126 - - HYPH cord-354827-ipg1vwmv 235 127 time time NN cord-354827-ipg1vwmv 235 128 PCR PCR NNP cord-354827-ipg1vwmv 235 129 Comparison comparison NN cord-354827-ipg1vwmv 235 130 of of IN cord-354827-ipg1vwmv 235 131 blood blood NN cord-354827-ipg1vwmv 235 132 culture culture NN cord-354827-ipg1vwmv 235 133 and and CC cord-354827-ipg1vwmv 235 134 realtime realtime NN cord-354827-ipg1vwmv 235 135 PCR PCR NNP cord-354827-ipg1vwmv 235 136 for for IN cord-354827-ipg1vwmv 235 137 the the DT cord-354827-ipg1vwmv 235 138 detection detection NN cord-354827-ipg1vwmv 235 139 of of IN cord-354827-ipg1vwmv 235 140 Invasive invasive JJ cord-354827-ipg1vwmv 235 141 Salmonella Salmonella NNP cord-354827-ipg1vwmv 235 142 serovars serovar NNS cord-354827-ipg1vwmv 235 143 in in IN cord-354827-ipg1vwmv 235 144 blood blood NN cord-354827-ipg1vwmv 235 145 and and CC cord-354827-ipg1vwmv 235 146 bone bone NN cord-354827-ipg1vwmv 235 147 marrow marrow NN cord-354827-ipg1vwmv 235 148 specimens specimen NNS cord-354827-ipg1vwmv 235 149 from from IN cord-354827-ipg1vwmv 235 150 enteric enteric JJ cord-354827-ipg1vwmv 235 151 fever fever NN cord-354827-ipg1vwmv 235 152 patients patient NNS cord-354827-ipg1vwmv 235 153 Using use VBG cord-354827-ipg1vwmv 235 154 DNA dna NN cord-354827-ipg1vwmv 235 155 microarrays microarray NNS cord-354827-ipg1vwmv 235 156 to to TO cord-354827-ipg1vwmv 235 157 study study VB cord-354827-ipg1vwmv 235 158 host host NN cord-354827-ipg1vwmv 235 159 - - HYPH cord-354827-ipg1vwmv 235 160 microbe microbe NN cord-354827-ipg1vwmv 235 161 interactions interaction NNS cord-354827-ipg1vwmv 235 162 InnateDB InnateDB NNP cord-354827-ipg1vwmv 235 163 : : : cord-354827-ipg1vwmv 235 164 facilitating facilitate VBG cord-354827-ipg1vwmv 235 165 systems system NNS cord-354827-ipg1vwmv 235 166 - - HYPH cord-354827-ipg1vwmv 235 167 level level NN cord-354827-ipg1vwmv 235 168 analyses analysis NNS cord-354827-ipg1vwmv 235 169 of of IN cord-354827-ipg1vwmv 235 170 the the DT cord-354827-ipg1vwmv 235 171 mammalian mammalian JJ cord-354827-ipg1vwmv 235 172 innate innate JJ cord-354827-ipg1vwmv 235 173 immune immune JJ cord-354827-ipg1vwmv 235 174 response response NN cord-354827-ipg1vwmv 235 175 Biomarker Biomarker NNP cord-354827-ipg1vwmv 235 176 discovery discovery NN cord-354827-ipg1vwmv 235 177 in in IN cord-354827-ipg1vwmv 235 178 infectious infectious JJ cord-354827-ipg1vwmv 235 179 diseases disease NNS cord-354827-ipg1vwmv 235 180 using use VBG cord-354827-ipg1vwmv 235 181 SELDI SELDI NNP cord-354827-ipg1vwmv 235 182 Identification Identification NNP cord-354827-ipg1vwmv 235 183 and and CC cord-354827-ipg1vwmv 235 184 characterization characterization NN cord-354827-ipg1vwmv 235 185 of of IN cord-354827-ipg1vwmv 235 186 Mycobacterium Mycobacterium NNP cord-354827-ipg1vwmv 235 187 tuberculosis tuberculosis NN cord-354827-ipg1vwmv 235 188 antigens antigen NNS cord-354827-ipg1vwmv 235 189 in in IN cord-354827-ipg1vwmv 235 190 urine urine NN cord-354827-ipg1vwmv 235 191 of of IN cord-354827-ipg1vwmv 235 192 patients patient NNS cord-354827-ipg1vwmv 235 193 with with IN cord-354827-ipg1vwmv 235 194 active active JJ cord-354827-ipg1vwmv 235 195 pulmonary pulmonary JJ cord-354827-ipg1vwmv 235 196 tuberculosis tuberculosis NN cord-354827-ipg1vwmv 235 197 : : : cord-354827-ipg1vwmv 235 198 an an DT cord-354827-ipg1vwmv 235 199 innovative innovative JJ cord-354827-ipg1vwmv 235 200 and and CC cord-354827-ipg1vwmv 235 201 alternative alternative JJ cord-354827-ipg1vwmv 235 202 approach approach NN cord-354827-ipg1vwmv 235 203 of of IN cord-354827-ipg1vwmv 235 204 antigen antigen NN cord-354827-ipg1vwmv 235 205 discovery discovery NN cord-354827-ipg1vwmv 235 206 of of IN cord-354827-ipg1vwmv 235 207 useful useful JJ cord-354827-ipg1vwmv 235 208 microbial microbial JJ cord-354827-ipg1vwmv 235 209 molecules molecule NNS cord-354827-ipg1vwmv 235 210 Proteomics Proteomics NNP cord-354827-ipg1vwmv 235 211 and and CC cord-354827-ipg1vwmv 235 212 severe severe JJ cord-354827-ipg1vwmv 235 213 acute acute JJ cord-354827-ipg1vwmv 235 214 respiratory respiratory JJ cord-354827-ipg1vwmv 235 215 syndrome syndrome NN cord-354827-ipg1vwmv 235 216 ( ( -LRB- cord-354827-ipg1vwmv 235 217 SARS SARS NNP cord-354827-ipg1vwmv 235 218 ) ) -RRB- cord-354827-ipg1vwmv 235 219 : : : cord-354827-ipg1vwmv 235 220 emerging emerge VBG cord-354827-ipg1vwmv 235 221 technology technology NN cord-354827-ipg1vwmv 235 222 meets meet VBZ cord-354827-ipg1vwmv 235 223 emerging emerge VBG cord-354827-ipg1vwmv 235 224 pathogen pathogen NN cord-354827-ipg1vwmv 235 225 Enzyme Enzyme NNP cord-354827-ipg1vwmv 235 226 - - HYPH cord-354827-ipg1vwmv 235 227 linked link VBN cord-354827-ipg1vwmv 235 228 immunosorbent immunosorbent JJ cord-354827-ipg1vwmv 235 229 assay assay NN cord-354827-ipg1vwmv 235 230 for for IN cord-354827-ipg1vwmv 235 231 detection detection NN cord-354827-ipg1vwmv 235 232 of of IN cord-354827-ipg1vwmv 235 233 Salmonella Salmonella NNP cord-354827-ipg1vwmv 235 234 typhi typhi NNP cord-354827-ipg1vwmv 235 235 Vi Vi NNP cord-354827-ipg1vwmv 235 236 antigen antigen NN cord-354827-ipg1vwmv 235 237 in in IN cord-354827-ipg1vwmv 235 238 urine urine NN cord-354827-ipg1vwmv 235 239 from from IN cord-354827-ipg1vwmv 235 240 typhoid typhoid NN cord-354827-ipg1vwmv 235 241 patients patient NNS cord-354827-ipg1vwmv 235 242 Rapid rapid JJ cord-354827-ipg1vwmv 235 243 diagnosis diagnosis NN cord-354827-ipg1vwmv 235 244 of of IN cord-354827-ipg1vwmv 235 245 typhoid typhoid NN cord-354827-ipg1vwmv 235 246 fever fever NN cord-354827-ipg1vwmv 235 247 by by IN cord-354827-ipg1vwmv 235 248 enzyme enzyme NN cord-354827-ipg1vwmv 235 249 - - HYPH cord-354827-ipg1vwmv 235 250 linked link VBN cord-354827-ipg1vwmv 235 251 immunosorbent immunosorbent JJ cord-354827-ipg1vwmv 235 252 assay assay NN cord-354827-ipg1vwmv 235 253 detection detection NN cord-354827-ipg1vwmv 235 254 of of IN cord-354827-ipg1vwmv 235 255 Salmonella Salmonella NNP cord-354827-ipg1vwmv 235 256 serotype serotype NN cord-354827-ipg1vwmv 235 257 typhi typhi NN cord-354827-ipg1vwmv 235 258 antigens antigen NNS cord-354827-ipg1vwmv 235 259 in in IN cord-354827-ipg1vwmv 235 260 urine urine NN cord-354827-ipg1vwmv 235 261 Precise precise JJ cord-354827-ipg1vwmv 235 262 estimation estimation NN cord-354827-ipg1vwmv 235 263 of of IN cord-354827-ipg1vwmv 235 264 the the DT cord-354827-ipg1vwmv 235 265 numbers number NNS cord-354827-ipg1vwmv 235 266 of of IN cord-354827-ipg1vwmv 235 267 chronic chronic JJ cord-354827-ipg1vwmv 235 268 carriers carrier NNS cord-354827-ipg1vwmv 235 269 of of IN cord-354827-ipg1vwmv 235 270 Salmonella Salmonella NNP cord-354827-ipg1vwmv 235 271 typhi typhi NNS cord-354827-ipg1vwmv 235 272 in in IN cord-354827-ipg1vwmv 235 273 Santiago Santiago NNP cord-354827-ipg1vwmv 235 274 , , , cord-354827-ipg1vwmv 235 275 Chile Chile NNP cord-354827-ipg1vwmv 235 276 , , , cord-354827-ipg1vwmv 235 277 an an DT cord-354827-ipg1vwmv 235 278 endemic endemic JJ cord-354827-ipg1vwmv 235 279 area area NN cord-354827-ipg1vwmv 235 280 Gallbladder gallbladder NN cord-354827-ipg1vwmv 235 281 carriage carriage NN cord-354827-ipg1vwmv 235 282 of of IN cord-354827-ipg1vwmv 235 283 Salmonella Salmonella NNP cord-354827-ipg1vwmv 235 284 paratyphi paratyphi NNP cord-354827-ipg1vwmv 236 1 A a DT cord-354827-ipg1vwmv 236 2 may may MD cord-354827-ipg1vwmv 236 3 be be VB cord-354827-ipg1vwmv 236 4 an an DT cord-354827-ipg1vwmv 236 5 important important JJ cord-354827-ipg1vwmv 236 6 factor factor NN cord-354827-ipg1vwmv 236 7 in in IN cord-354827-ipg1vwmv 236 8 the the DT cord-354827-ipg1vwmv 236 9 increasing increase VBG cord-354827-ipg1vwmv 236 10 incidence incidence NN cord-354827-ipg1vwmv 236 11 of of IN cord-354827-ipg1vwmv 236 12 this this DT cord-354827-ipg1vwmv 236 13 infection infection NN cord-354827-ipg1vwmv 236 14 in in IN cord-354827-ipg1vwmv 236 15 South South NNP cord-354827-ipg1vwmv 236 16 Asia Asia NNP cord-354827-ipg1vwmv 236 17 Vi Vi NNP cord-354827-ipg1vwmv 236 18 serology serology NN cord-354827-ipg1vwmv 236 19 in in IN cord-354827-ipg1vwmv 236 20 detection detection NN cord-354827-ipg1vwmv 236 21 of of IN cord-354827-ipg1vwmv 236 22 chronic chronic JJ cord-354827-ipg1vwmv 236 23 Salmonella Salmonella NNP cord-354827-ipg1vwmv 236 24 typhi typhi NN cord-354827-ipg1vwmv 236 25 carriers carrier NNS cord-354827-ipg1vwmv 236 26 in in IN cord-354827-ipg1vwmv 236 27 an an DT cord-354827-ipg1vwmv 236 28 endemic endemic JJ cord-354827-ipg1vwmv 236 29 area area NN cord-354827-ipg1vwmv 236 30 Pre pre NN cord-354827-ipg1vwmv 236 31 - - JJ cord-354827-ipg1vwmv 236 32 publication publication JJ cord-354827-ipg1vwmv 236 33 history history NN cord-354827-ipg1vwmv 237 1 The the DT cord-354827-ipg1vwmv 237 2 pre pre JJ cord-354827-ipg1vwmv 237 3 - - JJ cord-354827-ipg1vwmv 237 4 publication publication JJ cord-354827-ipg1vwmv 237 5 history history NN cord-354827-ipg1vwmv 237 6 for for IN cord-354827-ipg1vwmv 237 7 this this DT cord-354827-ipg1vwmv 237 8 paper paper NN cord-354827-ipg1vwmv 237 9 can can MD cord-354827-ipg1vwmv 237 10 be be VB cord-354827-ipg1vwmv 237 11 accessed access VBN cord-354827-ipg1vwmv 237 12 here here RB cord-354827-ipg1vwmv 237 13 Searching search VBG cord-354827-ipg1vwmv 237 14 for for IN cord-354827-ipg1vwmv 237 15 the the DT cord-354827-ipg1vwmv 237 16 elusive elusive JJ cord-354827-ipg1vwmv 237 17 typhoid typhoid NN cord-354827-ipg1vwmv 237 18 diagnostic diagnostic JJ cord-354827-ipg1vwmv 238 1 This this DT cord-354827-ipg1vwmv 238 2 was be VBD cord-354827-ipg1vwmv 238 3 supported support VBN cord-354827-ipg1vwmv 238 4 by by IN cord-354827-ipg1vwmv 238 5 the the DT cord-354827-ipg1vwmv 238 6 Wellcome Wellcome NNP cord-354827-ipg1vwmv 238 7 Trust Trust NNP cord-354827-ipg1vwmv 238 8 and and CC cord-354827-ipg1vwmv 238 9 the the DT cord-354827-ipg1vwmv 238 10 International International NNP cord-354827-ipg1vwmv 238 11 Vaccine Vaccine NNP cord-354827-ipg1vwmv 238 12 Institute Institute NNP cord-354827-ipg1vwmv 238 13 , , , cord-354827-ipg1vwmv 238 14 Seoul Seoul NNP cord-354827-ipg1vwmv 238 15 , , , cord-354827-ipg1vwmv 238 16 Korea Korea NNP cord-354827-ipg1vwmv 238 17 . . . cord-354827-ipg1vwmv 239 1 SB SB NNP cord-354827-ipg1vwmv 239 2 is be VBZ cord-354827-ipg1vwmv 239 3 supported support VBN cord-354827-ipg1vwmv 239 4 by by IN cord-354827-ipg1vwmv 239 5 an an DT cord-354827-ipg1vwmv 239 6 OAK OAK NNP cord-354827-ipg1vwmv 239 7 foundation foundation NN cord-354827-ipg1vwmv 239 8 fellowship fellowship NN cord-354827-ipg1vwmv 239 9 through through IN cord-354827-ipg1vwmv 239 10 Oxford Oxford NNP cord-354827-ipg1vwmv 239 11 University University NNP cord-354827-ipg1vwmv 239 12 . . . cord-354827-ipg1vwmv 240 1 Authors author NNS cord-354827-ipg1vwmv 240 2 ' ' POS cord-354827-ipg1vwmv 240 3 contributions contribution NNS cord-354827-ipg1vwmv 240 4 SB SB NNP cord-354827-ipg1vwmv 240 5 , , , cord-354827-ipg1vwmv 240 6 MF MF NNP cord-354827-ipg1vwmv 240 7 and and CC cord-354827-ipg1vwmv 240 8 GD GD NNP cord-354827-ipg1vwmv 240 9 were be VBD cord-354827-ipg1vwmv 240 10 responsible responsible JJ cord-354827-ipg1vwmv 240 11 for for IN cord-354827-ipg1vwmv 240 12 the the DT cord-354827-ipg1vwmv 240 13 concept concept NN cord-354827-ipg1vwmv 240 14 , , , cord-354827-ipg1vwmv 240 15 the the DT cord-354827-ipg1vwmv 240 16 content content NN cord-354827-ipg1vwmv 240 17 and and CC cord-354827-ipg1vwmv 240 18 the the DT cord-354827-ipg1vwmv 240 19 writing writing NN cord-354827-ipg1vwmv 240 20 of of IN cord-354827-ipg1vwmv 240 21 the the DT cord-354827-ipg1vwmv 240 22 manuscript manuscript NN cord-354827-ipg1vwmv 240 23 . . . cord-354827-ipg1vwmv 241 1 All all DT cord-354827-ipg1vwmv 241 2 authors author NNS cord-354827-ipg1vwmv 241 3 have have VBP cord-354827-ipg1vwmv 241 4 read read VBN cord-354827-ipg1vwmv 241 5 and and CC cord-354827-ipg1vwmv 241 6 approved approve VBD cord-354827-ipg1vwmv 241 7 this this DT cord-354827-ipg1vwmv 241 8 manuscript manuscript NN cord-354827-ipg1vwmv 241 9 . . . cord-354827-ipg1vwmv 242 1 The the DT cord-354827-ipg1vwmv 242 2 authors author NNS cord-354827-ipg1vwmv 242 3 declare declare VBP cord-354827-ipg1vwmv 242 4 that that IN cord-354827-ipg1vwmv 242 5 they -PRON- PRP cord-354827-ipg1vwmv 242 6 have have VBP cord-354827-ipg1vwmv 242 7 no no DT cord-354827-ipg1vwmv 242 8 competing compete VBG cord-354827-ipg1vwmv 242 9 interests interest NNS cord-354827-ipg1vwmv 242 10 . . . cord-354827-ipg1vwmv 242 11 _SP