id author title date pages extension mime words sentences flesch summary cache txt cord-260550-ld9eieik Ng, Man Wai The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese 2007-06-01 .txt text/plain 2839 164 63 title: The association of RANTES polymorphism with severe acute respiratory syndrome in Hong Kong and Beijing Chinese In this study, we investigated the single nucleotide polymorphisms (SNPs) of inflammatory chemokine genes, i.e. RANTES, IP-10 and monokine induced by gamma interferon gene (Mig) in two Chinese cohorts from Hong Kong and Beijing and found that the RANTES -28 G allele was associated with disease susceptibility and severity of SARS. Among them, 20 patients were classified as severe group, which were identified by their admissions to intensive care units or deaths from SARS (mean ± SD age = 39.45 ± 12.8, 11 male and 9 female). After correction by Bonferroni method, the significant P value should be less than 0.007 This study showed that RANTES -28 G allele was a risk factor that associated with severe clinical outcomes in both Hong Kong and Beijing Chinese SARS patients. ./cache/cord-260550-ld9eieik.txt ./txt/cord-260550-ld9eieik.txt