id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-032382-5tp9i9vh	Hackert, Volker H.	Signs and symptoms do not predict, but may help rule out acute Q fever in favour of other respiratory tract infections, and reduce antibiotics overuse in primary care	2020-09-21		.txt	text/plain	5644	230	44	CONCLUSION: Whereas signs and symptoms of disease do not appear to predict acute Q fever, they may help rule it out in favour of other respiratory conditions, prompting a delayed or non-prescribing approach instead of early empiric doxycycline in primary care patients with non-severe presentations. Specifically, we assessed whether signs and symptoms could accurately identify acute Q fever in suspect cases prior to laboratory confirmation, or help rule out the diagnosis in favour of other respiratory infections where, depending on national guidelines, treatment with amoxicillin as a first-line antibiotic or a delayed or non-prescribing approach would be considered more appropriate. We performed a retrospective case-control study assessing the association of acute Q fever case status with signs and symptoms of disease in a sample of questionnaire respondents from the cohort of all individuals tested for acute Q fever by GP's or hospital-based medical specialists in the period from March 2009 through April 2010 (n = 1218).	./cache/cord-032382-5tp9i9vh.txt	./txt/cord-032382-5tp9i9vh.txt