id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000963-pwz6rde0	Kalugalage, Thilini	Low serum total nitrite and nitrate levels in severe leptospirosis	2013-05-06		.txt	text/plain	4065	225	53	We previously demonstrated through a preliminary study that serum nitrite levels are elevated in patients with acute leptospirosis compared to healthy controls [20] . The aim of this study was to determine the relationship between NO x (i.e., total nitrite and nitrate) levels in the blood (as a marker of iNOS activity) and disease severity in leptospirosis. The objectives of our study were to a) determine serum NO x (nitrate and nitrite) levels in patients with confirmed leptospirosis, b) compare serum NO x levels in leptospirosis patients with mild and severe disease, healthy controls and non-leptospirosis fever patients (NLFs), and c) seek a correlation between serum NO x levels and disease severity after correcting for impaired renal clearance. Patients with severe leptospirosis were defined as those presenting with acute fever and clinical symptoms compatible with leptospirosis (confirmed serologically by a positive MAT result) with two or more of the following criteria: jaundice (bilirubin> 51.3 μmol/l), oliguria (urine output < 400 ml/day), serum creatinine> 133 μmol/l or blood urea > 25.5 mmol/l [14] , or the presence of acute organ dysfunction.	./cache/cord-000963-pwz6rde0.txt	./txt/cord-000963-pwz6rde0.txt