id sid tid token lemma pos cord-351472-ch004jxy 1 1 key key JJ cord-351472-ch004jxy 2 1 : : : cord-351472-ch004jxy 2 2 cord-351472-ch004jxy cord-351472-ch004jxy CD cord-351472-ch004jxy 2 3 authors author NNS cord-351472-ch004jxy 2 4 : : : cord-351472-ch004jxy 2 5 Vashi Vashi NNP cord-351472-ch004jxy 2 6 , , , cord-351472-ch004jxy 2 7 Yoya Yoya NNP cord-351472-ch004jxy 2 8 ; ; : cord-351472-ch004jxy 2 9 Jagrit Jagrit NNP cord-351472-ch004jxy 2 10 , , , cord-351472-ch004jxy 2 11 Vipin Vipin NNP cord-351472-ch004jxy 2 12 ; ; : cord-351472-ch004jxy 2 13 Kumar Kumar NNP cord-351472-ch004jxy 2 14 , , , cord-351472-ch004jxy 3 1 Sachin Sachin NNP cord-351472-ch004jxy 3 2 title title NN cord-351472-ch004jxy 3 3 : : : cord-351472-ch004jxy 4 1 Understanding understand VBG cord-351472-ch004jxy 4 2 the the DT cord-351472-ch004jxy 4 3 B b NN cord-351472-ch004jxy 4 4 and and CC cord-351472-ch004jxy 4 5 T T NNP cord-351472-ch004jxy 4 6 cells cell NNS cord-351472-ch004jxy 4 7 epitopes epitope NNS cord-351472-ch004jxy 4 8 of of IN cord-351472-ch004jxy 4 9 spike spike NN cord-351472-ch004jxy 4 10 protein protein NN cord-351472-ch004jxy 4 11 of of IN cord-351472-ch004jxy 4 12 severe severe JJ cord-351472-ch004jxy 4 13 respiratory respiratory JJ cord-351472-ch004jxy 4 14 syndrome syndrome NN cord-351472-ch004jxy 4 15 coronavirus-2 coronavirus-2 NN cord-351472-ch004jxy 4 16 : : : cord-351472-ch004jxy 5 1 A a DT cord-351472-ch004jxy 5 2 computational computational JJ cord-351472-ch004jxy 5 3 way way NN cord-351472-ch004jxy 5 4 to to TO cord-351472-ch004jxy 5 5 predict predict VB cord-351472-ch004jxy 5 6 the the DT cord-351472-ch004jxy 5 7 immunogens immunogens JJ cord-351472-ch004jxy 5 8 date date NN cord-351472-ch004jxy 5 9 : : : cord-351472-ch004jxy 5 10 2020 2020 CD cord-351472-ch004jxy 5 11 - - HYPH cord-351472-ch004jxy 5 12 04 04 CD cord-351472-ch004jxy 5 13 - - SYM cord-351472-ch004jxy 5 14 10 10 CD cord-351472-ch004jxy 5 15 journal journal NN cord-351472-ch004jxy 5 16 : : : cord-351472-ch004jxy 6 1 bioRxiv biorxiv IN cord-351472-ch004jxy 6 2 DOI DOI NNP cord-351472-ch004jxy 6 3 : : : cord-351472-ch004jxy 7 1 10.1101/2020.04.08.013516 10.1101/2020.04.08.013516 CD cord-351472-ch004jxy 7 2 sha sha NNP cord-351472-ch004jxy 7 3 : : : cord-351472-ch004jxy 7 4 fa58c3b4973f746a34820f57993b0a8c9d05f076 fa58c3b4973f746a34820f57993b0a8c9d05f076 NNP cord-351472-ch004jxy 7 5 doc_id doc_id NNPS cord-351472-ch004jxy 7 6 : : : cord-351472-ch004jxy 7 7 351472 351472 CD cord-351472-ch004jxy 7 8 cord_uid cord_uid NNS cord-351472-ch004jxy 7 9 : : : cord-351472-ch004jxy 7 10 ch004jxy ch004jxy ADD cord-351472-ch004jxy 8 1 The the DT cord-351472-ch004jxy 8 2 2019 2019 CD cord-351472-ch004jxy 8 3 novel novel NN cord-351472-ch004jxy 8 4 severe severe JJ cord-351472-ch004jxy 8 5 respiratory respiratory JJ cord-351472-ch004jxy 8 6 syndrome syndrome NN cord-351472-ch004jxy 8 7 coronavirus-2 coronavirus-2 NN cord-351472-ch004jxy 9 1 ( ( -LRB- cord-351472-ch004jxy 9 2 SARS SARS NNP cord-351472-ch004jxy 9 3 - - HYPH cord-351472-ch004jxy 9 4 CoV-2 CoV-2 NNP cord-351472-ch004jxy 9 5 ) ) -RRB- cord-351472-ch004jxy 9 6 outbreak outbreak NN cord-351472-ch004jxy 9 7 has have VBZ cord-351472-ch004jxy 9 8 caused cause VBN cord-351472-ch004jxy 9 9 a a DT cord-351472-ch004jxy 9 10 large large JJ cord-351472-ch004jxy 9 11 number number NN cord-351472-ch004jxy 9 12 of of IN cord-351472-ch004jxy 9 13 deaths death NNS cord-351472-ch004jxy 9 14 with with IN cord-351472-ch004jxy 9 15 thousands thousand NNS cord-351472-ch004jxy 9 16 of of IN cord-351472-ch004jxy 9 17 confirmed confirm VBN cord-351472-ch004jxy 9 18 cases case NNS cord-351472-ch004jxy 9 19 worldwide worldwide RB cord-351472-ch004jxy 9 20 . . . cord-351472-ch004jxy 10 1 The the DT cord-351472-ch004jxy 10 2 present present JJ cord-351472-ch004jxy 10 3 study study NN cord-351472-ch004jxy 10 4 followed follow VBD cord-351472-ch004jxy 10 5 computational computational JJ cord-351472-ch004jxy 10 6 approaches approach NNS cord-351472-ch004jxy 10 7 to to TO cord-351472-ch004jxy 10 8 identify identify VB cord-351472-ch004jxy 10 9 B- B- NNP cord-351472-ch004jxy 10 10 and and CC cord-351472-ch004jxy 10 11 T t NN cord-351472-ch004jxy 10 12 - - HYPH cord-351472-ch004jxy 10 13 cell cell NN cord-351472-ch004jxy 10 14 epitopes epitope NNS cord-351472-ch004jxy 10 15 for for IN cord-351472-ch004jxy 10 16 spike spike NN cord-351472-ch004jxy 10 17 glycoprotein glycoprotein NN cord-351472-ch004jxy 10 18 of of IN cord-351472-ch004jxy 10 19 SARS SARS NNP cord-351472-ch004jxy 10 20 - - HYPH cord-351472-ch004jxy 10 21 CoV-2 CoV-2 NNP cord-351472-ch004jxy 10 22 by by IN cord-351472-ch004jxy 10 23 its -PRON- PRP$ cord-351472-ch004jxy 10 24 interactions interaction NNS cord-351472-ch004jxy 10 25 with with IN cord-351472-ch004jxy 10 26 the the DT cord-351472-ch004jxy 10 27 human human JJ cord-351472-ch004jxy 10 28 leukocyte leukocyte NN cord-351472-ch004jxy 10 29 antigen antigen NN cord-351472-ch004jxy 10 30 alleles allele NNS cord-351472-ch004jxy 10 31 . . . cord-351472-ch004jxy 11 1 We -PRON- PRP cord-351472-ch004jxy 11 2 identified identify VBD cord-351472-ch004jxy 11 3 twenty twenty CD cord-351472-ch004jxy 11 4 - - HYPH cord-351472-ch004jxy 11 5 four four CD cord-351472-ch004jxy 11 6 peptide peptide NN cord-351472-ch004jxy 11 7 stretches stretch VBZ cord-351472-ch004jxy 11 8 on on IN cord-351472-ch004jxy 11 9 the the DT cord-351472-ch004jxy 11 10 SARS SARS NNP cord-351472-ch004jxy 11 11 - - HYPH cord-351472-ch004jxy 11 12 CoV-2 CoV-2 NNP cord-351472-ch004jxy 11 13 spike spike NN cord-351472-ch004jxy 11 14 protein protein NN cord-351472-ch004jxy 11 15 that that WDT cord-351472-ch004jxy 11 16 are be VBP cord-351472-ch004jxy 11 17 well well RB cord-351472-ch004jxy 11 18 conserved conserve VBN cord-351472-ch004jxy 11 19 among among IN cord-351472-ch004jxy 11 20 the the DT cord-351472-ch004jxy 11 21 reported report VBN cord-351472-ch004jxy 11 22 strains strain NNS cord-351472-ch004jxy 11 23 . . . cord-351472-ch004jxy 12 1 The the DT cord-351472-ch004jxy 12 2 S S NNP cord-351472-ch004jxy 12 3 protein protein NN cord-351472-ch004jxy 12 4 structure structure NN cord-351472-ch004jxy 12 5 further further RB cord-351472-ch004jxy 12 6 validated validate VBD cord-351472-ch004jxy 12 7 the the DT cord-351472-ch004jxy 12 8 presence presence NN cord-351472-ch004jxy 12 9 of of IN cord-351472-ch004jxy 12 10 predicted predict VBN cord-351472-ch004jxy 12 11 peptides peptide NNS cord-351472-ch004jxy 12 12 on on IN cord-351472-ch004jxy 12 13 the the DT cord-351472-ch004jxy 12 14 surface surface NN cord-351472-ch004jxy 12 15 . . . cord-351472-ch004jxy 13 1 Out out IN cord-351472-ch004jxy 13 2 of of IN cord-351472-ch004jxy 13 3 which which WDT cord-351472-ch004jxy 13 4 twenty twenty CD cord-351472-ch004jxy 13 5 are be VBP cord-351472-ch004jxy 13 6 surface surface NN cord-351472-ch004jxy 13 7 exposed expose VBN cord-351472-ch004jxy 13 8 and and CC cord-351472-ch004jxy 13 9 predicted predict VBN cord-351472-ch004jxy 13 10 to to TO cord-351472-ch004jxy 13 11 have have VB cord-351472-ch004jxy 13 12 reasonable reasonable JJ cord-351472-ch004jxy 13 13 epitope epitope NN cord-351472-ch004jxy 13 14 binding bind VBG cord-351472-ch004jxy 13 15 efficiency efficiency NN cord-351472-ch004jxy 13 16 . . . cord-351472-ch004jxy 14 1 The the DT cord-351472-ch004jxy 14 2 work work NN cord-351472-ch004jxy 14 3 could could MD cord-351472-ch004jxy 14 4 be be VB cord-351472-ch004jxy 14 5 useful useful JJ cord-351472-ch004jxy 14 6 for for IN cord-351472-ch004jxy 14 7 understanding understand VBG cord-351472-ch004jxy 14 8 the the DT cord-351472-ch004jxy 14 9 immunodominant immunodominant JJ cord-351472-ch004jxy 14 10 regions region NNS cord-351472-ch004jxy 14 11 in in IN cord-351472-ch004jxy 14 12 the the DT cord-351472-ch004jxy 14 13 surface surface NN cord-351472-ch004jxy 14 14 protein protein NN cord-351472-ch004jxy 14 15 of of IN cord-351472-ch004jxy 14 16 SARS SARS NNP cord-351472-ch004jxy 14 17 - - HYPH cord-351472-ch004jxy 14 18 CoV-2 CoV-2 NNP cord-351472-ch004jxy 14 19 and and CC cord-351472-ch004jxy 14 20 could could MD cord-351472-ch004jxy 14 21 potentially potentially RB cord-351472-ch004jxy 14 22 help help VB cord-351472-ch004jxy 14 23 in in IN cord-351472-ch004jxy 14 24 designing design VBG cord-351472-ch004jxy 14 25 some some DT cord-351472-ch004jxy 14 26 peptide peptide NN cord-351472-ch004jxy 14 27 - - HYPH cord-351472-ch004jxy 14 28 based base VBN cord-351472-ch004jxy 14 29 diagnostics diagnostic NNS cord-351472-ch004jxy 14 30 . . . cord-351472-ch004jxy 15 1 binding bind VBG cord-351472-ch004jxy 15 2 domains domain NNS cord-351472-ch004jxy 15 3 of of IN cord-351472-ch004jxy 15 4 S s NN cord-351472-ch004jxy 15 5 proteins protein NNS cord-351472-ch004jxy 15 6 of of IN cord-351472-ch004jxy 15 7 SARS SARS NNP cord-351472-ch004jxy 15 8 - - HYPH cord-351472-ch004jxy 15 9 CoV-2 CoV-2 NNP cord-351472-ch004jxy 15 10 and and CC cord-351472-ch004jxy 15 11 SARS SARS NNP cord-351472-ch004jxy 15 12 - - HYPH cord-351472-ch004jxy 15 13 CoV CoV NNP cord-351472-ch004jxy 15 14 bind bind NN cord-351472-ch004jxy 15 15 with with IN cord-351472-ch004jxy 15 16 similar similar JJ cord-351472-ch004jxy 15 17 affinities affinity NNS cord-351472-ch004jxy 15 18 to to IN cord-351472-ch004jxy 15 19 74 74 CD cord-351472-ch004jxy 15 20 human human NN cord-351472-ch004jxy 15 21 ACE2 ACE2 NNP cord-351472-ch004jxy 15 22 11,12 11,12 CD cord-351472-ch004jxy 15 23 . . . cord-351472-ch004jxy 16 1 75 75 CD cord-351472-ch004jxy 17 1 As as IN cord-351472-ch004jxy 17 2 the the DT cord-351472-ch004jxy 17 3 situation situation NN cord-351472-ch004jxy 17 4 worsens worsen VBZ cord-351472-ch004jxy 17 5 , , , cord-351472-ch004jxy 17 6 there there EX cord-351472-ch004jxy 17 7 is be VBZ cord-351472-ch004jxy 17 8 a a DT cord-351472-ch004jxy 17 9 growing grow VBG cord-351472-ch004jxy 17 10 need need NN cord-351472-ch004jxy 17 11 for for IN cord-351472-ch004jxy 17 12 the the DT cord-351472-ch004jxy 17 13 development development NN cord-351472-ch004jxy 17 14 of of IN cord-351472-ch004jxy 17 15 suitable suitable JJ cord-351472-ch004jxy 17 16 76 76 CD cord-351472-ch004jxy 17 17 therapeutics therapeutic NNS cord-351472-ch004jxy 17 18 and and CC cord-351472-ch004jxy 17 19 alternate alternate JJ cord-351472-ch004jxy 17 20 diagnostics diagnostic NNS cord-351472-ch004jxy 17 21 against against IN cord-351472-ch004jxy 17 22 SARS SARS NNP cord-351472-ch004jxy 17 23 - - HYPH cord-351472-ch004jxy 17 24 CoV-2 CoV-2 NNP cord-351472-ch004jxy 17 25 for for IN cord-351472-ch004jxy 17 26 effective effective JJ cord-351472-ch004jxy 17 27 disease disease NN cord-351472-ch004jxy 17 28 management management NN cord-351472-ch004jxy 17 29 77 77 CD cord-351472-ch004jxy 17 30 strategies strategy NNS cord-351472-ch004jxy 17 31 . . . cord-351472-ch004jxy 18 1 Diagnostic diagnostic JJ cord-351472-ch004jxy 18 2 assays assay NNS cord-351472-ch004jxy 18 3 based base VBN cord-351472-ch004jxy 18 4 on on IN cord-351472-ch004jxy 18 5 peptides peptide NNS cord-351472-ch004jxy 18 6 have have VBP cord-351472-ch004jxy 18 7 become become VBN cord-351472-ch004jxy 18 8 increasingly increasingly RB cord-351472-ch004jxy 18 9 substantial substantial JJ cord-351472-ch004jxy 18 10 and and CC cord-351472-ch004jxy 18 11 78 78 CD cord-351472-ch004jxy 18 12 indispensable indispensable JJ cord-351472-ch004jxy 18 13 for for IN cord-351472-ch004jxy 18 14 its -PRON- PRP$ cord-351472-ch004jxy 18 15 advantages advantage NNS cord-351472-ch004jxy 18 16 over over IN cord-351472-ch004jxy 18 17 conventional conventional JJ cord-351472-ch004jxy 18 18 methods method NNS cord-351472-ch004jxy 18 19 13 13 CD cord-351472-ch004jxy 18 20 . . . cord-351472-ch004jxy 19 1 The the DT cord-351472-ch004jxy 19 2 present present JJ cord-351472-ch004jxy 19 3 study study NN cord-351472-ch004jxy 19 4 aimed aim VBN cord-351472-ch004jxy 19 5 to to IN cord-351472-ch004jxy 19 6 79 79 CD cord-351472-ch004jxy 19 7 locate locate VB cord-351472-ch004jxy 19 8 appropriate appropriate JJ cord-351472-ch004jxy 19 9 epitopes epitope NNS cord-351472-ch004jxy 19 10 within within IN cord-351472-ch004jxy 19 11 a a DT cord-351472-ch004jxy 19 12 particular particular JJ cord-351472-ch004jxy 19 13 protein protein NN cord-351472-ch004jxy 19 14 antigen antigen NN cord-351472-ch004jxy 19 15 , , , cord-351472-ch004jxy 19 16 which which WDT cord-351472-ch004jxy 19 17 can can MD cord-351472-ch004jxy 19 18 elicit elicit VB cord-351472-ch004jxy 19 19 an an DT cord-351472-ch004jxy 19 20 immune immune JJ cord-351472-ch004jxy 19 21 80 80 CD cord-351472-ch004jxy 19 22 response response NN cord-351472-ch004jxy 19 23 that that WDT cord-351472-ch004jxy 19 24 could could MD cord-351472-ch004jxy 19 25 be be VB cord-351472-ch004jxy 19 26 selected select VBN cord-351472-ch004jxy 19 27 for for IN cord-351472-ch004jxy 19 28 the the DT cord-351472-ch004jxy 19 29 synthesis synthesis NN cord-351472-ch004jxy 19 30 of of IN cord-351472-ch004jxy 19 31 the the DT cord-351472-ch004jxy 19 32 immunogenic immunogenic JJ cord-351472-ch004jxy 19 33 peptide peptide NN cord-351472-ch004jxy 19 34 . . . cord-351472-ch004jxy 20 1 Using use VBG cord-351472-ch004jxy 20 2 81 81 CD cord-351472-ch004jxy 20 3 computational computational JJ cord-351472-ch004jxy 20 4 approach approach NN cord-351472-ch004jxy 20 5 , , , cord-351472-ch004jxy 20 6 S S NNP cord-351472-ch004jxy 20 7 glycoprotein glycoprotein NN cord-351472-ch004jxy 20 8 of of IN cord-351472-ch004jxy 20 9 SARS SARS NNP cord-351472-ch004jxy 20 10 - - HYPH cord-351472-ch004jxy 20 11 CoV-2 CoV-2 NNP cord-351472-ch004jxy 20 12 was be VBD cord-351472-ch004jxy 20 13 explored explore VBN cord-351472-ch004jxy 20 14 to to TO cord-351472-ch004jxy 20 15 identify identify VB cord-351472-ch004jxy 20 16 various various JJ cord-351472-ch004jxy 20 17 82 82 CD cord-351472-ch004jxy 20 18 immunodominant immunodominant JJ cord-351472-ch004jxy 20 19 epitopes epitope NNS cord-351472-ch004jxy 20 20 for for IN cord-351472-ch004jxy 20 21 the the DT cord-351472-ch004jxy 20 22 development development NN cord-351472-ch004jxy 20 23 of of IN cord-351472-ch004jxy 20 24 diagnostics diagnostic NNS cord-351472-ch004jxy 20 25 . . . cord-351472-ch004jxy 21 1 Besides besides RB cord-351472-ch004jxy 21 2 , , , cord-351472-ch004jxy 21 3 the the DT cord-351472-ch004jxy 21 4 results result NNS cord-351472-ch004jxy 21 5 could could MD cord-351472-ch004jxy 21 6 also also RB cord-351472-ch004jxy 21 7 83 83 CD cord-351472-ch004jxy 21 8 help help VB cord-351472-ch004jxy 21 9 us -PRON- PRP cord-351472-ch004jxy 21 10 to to TO cord-351472-ch004jxy 21 11 understand understand VB cord-351472-ch004jxy 21 12 the the DT cord-351472-ch004jxy 21 13 SARS SARS NNP cord-351472-ch004jxy 21 14 - - HYPH cord-351472-ch004jxy 21 15 CoV-2 CoV-2 NNP cord-351472-ch004jxy 21 16 surface surface NN cord-351472-ch004jxy 21 17 protein protein NN cord-351472-ch004jxy 21 18 response response NN cord-351472-ch004jxy 21 19 towards towards IN cord-351472-ch004jxy 21 20 T T NNP cord-351472-ch004jxy 21 21 and and CC cord-351472-ch004jxy 21 22 B b NN cord-351472-ch004jxy 21 23 cells cell NNS cord-351472-ch004jxy 21 24 . . . cord-351472-ch004jxy 21 25 _SP cord-351472-ch004jxy 22 1 Collection collection NN cord-351472-ch004jxy 22 2 of of IN cord-351472-ch004jxy 22 3 targeted target VBN cord-351472-ch004jxy 22 4 protein protein NN cord-351472-ch004jxy 22 5 sequence sequence NN cord-351472-ch004jxy 22 6 87 87 CD cord-351472-ch004jxy 23 1 We -PRON- PRP cord-351472-ch004jxy 23 2 downloaded download VBD cord-351472-ch004jxy 23 3 amino amino NN cord-351472-ch004jxy 23 4 acid acid NN cord-351472-ch004jxy 23 5 sequences sequence NNS cord-351472-ch004jxy 23 6 ( ( -LRB- cord-351472-ch004jxy 23 7 n=98 n=98 NNP cord-351472-ch004jxy 23 8 ) ) -RRB- cord-351472-ch004jxy 23 9 of of IN cord-351472-ch004jxy 23 10 S S NNP cord-351472-ch004jxy 23 11 protein protein NN cord-351472-ch004jxy 23 12 available available JJ cord-351472-ch004jxy 23 13 at at IN cord-351472-ch004jxy 23 14 the the DT cord-351472-ch004jxy 23 15 time time NN cord-351472-ch004jxy 23 16 of of IN cord-351472-ch004jxy 23 17 study study NN cord-351472-ch004jxy 23 18 88 88 CD cord-351472-ch004jxy 23 19 on on IN cord-351472-ch004jxy 23 20 targeted target VBN cord-351472-ch004jxy 23 21 SARS SARS NNP cord-351472-ch004jxy 23 22 - - HYPH cord-351472-ch004jxy 23 23 CoV-2 CoV-2 NNP cord-351472-ch004jxy 23 24 from from IN cord-351472-ch004jxy 23 25 the the DT cord-351472-ch004jxy 23 26 National National NNP cord-351472-ch004jxy 23 27 Centre Centre NNP cord-351472-ch004jxy 23 28 for for IN cord-351472-ch004jxy 23 29 Biotechnological Biotechnological NNP cord-351472-ch004jxy 23 30 Information Information NNP cord-351472-ch004jxy 23 31 ( ( -LRB- cord-351472-ch004jxy 23 32 NCBI NCBI NNP cord-351472-ch004jxy 23 33 ) ) -RRB- cord-351472-ch004jxy 23 34 89 89 CD cord-351472-ch004jxy 23 35 database database NN cord-351472-ch004jxy 23 36 . . . cord-351472-ch004jxy 24 1 90 90 CD cord-351472-ch004jxy 24 2 Identification identification NN cord-351472-ch004jxy 24 3 of of IN cord-351472-ch004jxy 24 4 potential potential JJ cord-351472-ch004jxy 24 5 peptides peptide NNS cord-351472-ch004jxy 24 6 91 91 CD cord-351472-ch004jxy 25 1 To to TO cord-351472-ch004jxy 25 2 identify identify VB cord-351472-ch004jxy 25 3 an an DT cord-351472-ch004jxy 25 4 immunodominant immunodominant JJ cord-351472-ch004jxy 25 5 region region NN cord-351472-ch004jxy 25 6 , , , cord-351472-ch004jxy 25 7 it -PRON- PRP cord-351472-ch004jxy 25 8 is be VBZ cord-351472-ch004jxy 25 9 of of IN cord-351472-ch004jxy 25 10 extreme extreme JJ cord-351472-ch004jxy 25 11 importance importance NN cord-351472-ch004jxy 25 12 to to TO cord-351472-ch004jxy 25 13 select select VB cord-351472-ch004jxy 25 14 the the DT cord-351472-ch004jxy 25 15 92 92 CD cord-351472-ch004jxy 25 16 conserved conserve VBN cord-351472-ch004jxy 25 17 region region NN cord-351472-ch004jxy 25 18 within within IN cord-351472-ch004jxy 25 19 the the DT cord-351472-ch004jxy 25 20 S S NNP cord-351472-ch004jxy 25 21 protein protein NN cord-351472-ch004jxy 25 22 of of IN cord-351472-ch004jxy 25 23 SARS SARS NNP cord-351472-ch004jxy 25 24 - - HYPH cord-351472-ch004jxy 25 25 CoV-2 CoV-2 NNP cord-351472-ch004jxy 25 26 . . . cord-351472-ch004jxy 26 1 All all PDT cord-351472-ch004jxy 26 2 the the DT cord-351472-ch004jxy 26 3 sequences sequence NNS cord-351472-ch004jxy 26 4 were be VBD cord-351472-ch004jxy 26 5 compared compare VBN cord-351472-ch004jxy 26 6 93 93 CD cord-351472-ch004jxy 26 7 among among IN cord-351472-ch004jxy 26 8 themselves -PRON- PRP cord-351472-ch004jxy 26 9 for for IN cord-351472-ch004jxy 26 10 variability variability NN cord-351472-ch004jxy 26 11 using use VBG cord-351472-ch004jxy 26 12 protein protein NN cord-351472-ch004jxy 26 13 variability variability NN cord-351472-ch004jxy 26 14 server server NN cord-351472-ch004jxy 26 15 by by IN cord-351472-ch004jxy 26 16 Shannon Shannon NNP cord-351472-ch004jxy 26 17 method method NN cord-351472-ch004jxy 26 18 14 14 CD cord-351472-ch004jxy 26 19 . . . cord-351472-ch004jxy 27 1 The the DT cord-351472-ch004jxy 27 2 94 94 CD cord-351472-ch004jxy 27 3 average average JJ cord-351472-ch004jxy 27 4 solvent solvent NN cord-351472-ch004jxy 27 5 accessibility accessibility NN cord-351472-ch004jxy 27 6 ( ( -LRB- cord-351472-ch004jxy 27 7 ASA ASA NNP cord-351472-ch004jxy 27 8 ) ) -RRB- cord-351472-ch004jxy 27 9 profile profile NN cord-351472-ch004jxy 27 10 was be VBD cord-351472-ch004jxy 27 11 predicted predict VBN cord-351472-ch004jxy 27 12 for for IN cord-351472-ch004jxy 27 13 each each DT cord-351472-ch004jxy 27 14 sequence sequence NN cord-351472-ch004jxy 27 15 using use VBG cord-351472-ch004jxy 27 16 SABLE SABLE NNP cord-351472-ch004jxy 27 17 95 95 CD cord-351472-ch004jxy 27 18 server server NN cord-351472-ch004jxy 27 19 15 15 CD cord-351472-ch004jxy 27 20 . . . cord-351472-ch004jxy 28 1 BepiPred BepiPred NNP cord-351472-ch004jxy 28 2 1.0 1.0 CD cord-351472-ch004jxy 28 3 Linear Linear NNP cord-351472-ch004jxy 28 4 Epitope Epitope NNP cord-351472-ch004jxy 28 5 Prediction Prediction NNP cord-351472-ch004jxy 28 6 module module NN cord-351472-ch004jxy 28 7 [ [ -LRB- cord-351472-ch004jxy 28 8 16 16 CD cord-351472-ch004jxy 28 9 ] ] -RRB- cord-351472-ch004jxy 29 1 [ [ -LRB- cord-351472-ch004jxy 29 2 17 17 CD cord-351472-ch004jxy 29 3 ] ] -RRB- cord-351472-ch004jxy 29 4 [ [ -LRB- cord-351472-ch004jxy 29 5 18 18 CD cord-351472-ch004jxy 29 6 ] ] -RRB- cord-351472-ch004jxy 29 7 incorporated incorporate VBN cord-351472-ch004jxy 29 8 in in IN cord-351472-ch004jxy 29 9 Immune Immune NNP cord-351472-ch004jxy 29 10 Epitope Epitope NNP cord-351472-ch004jxy 29 11 96 96 CD cord-351472-ch004jxy 29 12 Database database NN cord-351472-ch004jxy 29 13 ( ( -LRB- cord-351472-ch004jxy 29 14 IEDB IEDB NNP cord-351472-ch004jxy 29 15 ) ) -RRB- cord-351472-ch004jxy 30 1 19 19 CD cord-351472-ch004jxy 30 2 was be VBD cord-351472-ch004jxy 30 3 used use VBN cord-351472-ch004jxy 30 4 to to TO cord-351472-ch004jxy 30 5 predict predict VB cord-351472-ch004jxy 30 6 potential potential JJ cord-351472-ch004jxy 30 7 epitopes epitope NNS cord-351472-ch004jxy 30 8 within within IN cord-351472-ch004jxy 30 9 the the DT cord-351472-ch004jxy 30 10 S S NNP cord-351472-ch004jxy 30 11 protein protein NN cord-351472-ch004jxy 30 12 . . . cord-351472-ch004jxy 31 1 The the DT cord-351472-ch004jxy 31 2 FASTA FASTA NNP cord-351472-ch004jxy 31 3 97 97 CD cord-351472-ch004jxy 31 4 sequence sequence NN cord-351472-ch004jxy 31 5 of of IN cord-351472-ch004jxy 31 6 the the DT cord-351472-ch004jxy 31 7 targeted target VBN cord-351472-ch004jxy 31 8 protein protein NN cord-351472-ch004jxy 31 9 was be VBD cord-351472-ch004jxy 31 10 used use VBN cord-351472-ch004jxy 31 11 as as IN cord-351472-ch004jxy 31 12 an an DT cord-351472-ch004jxy 31 13 input input NN cord-351472-ch004jxy 31 14 for for IN cord-351472-ch004jxy 31 15 all all PDT cord-351472-ch004jxy 31 16 the the DT cord-351472-ch004jxy 31 17 default default NN cord-351472-ch004jxy 31 18 parameters parameter NNS cord-351472-ch004jxy 31 19 . . . cord-351472-ch004jxy 32 1 98 98 CD cord-351472-ch004jxy 33 1 The the DT cord-351472-ch004jxy 33 2 potential potential JJ cord-351472-ch004jxy 33 3 epitopes epitope NNS cord-351472-ch004jxy 33 4 are be VBP cord-351472-ch004jxy 33 5 represented represent VBN cord-351472-ch004jxy 33 6 by by IN cord-351472-ch004jxy 33 7 blue blue JJ cord-351472-ch004jxy 33 8 peaks peak NNS cord-351472-ch004jxy 33 9 , , , cord-351472-ch004jxy 33 10 while while IN cord-351472-ch004jxy 33 11 green green JJ cord-351472-ch004jxy 33 12 - - HYPH cord-351472-ch004jxy 33 13 colored colored JJ cord-351472-ch004jxy 33 14 slopes slope NNS cord-351472-ch004jxy 33 15 represent represent VBP cord-351472-ch004jxy 33 16 non-124 non-124 NNP cord-351472-ch004jxy 33 17 epitopic epitopic JJ cord-351472-ch004jxy 33 18 regions region NNS cord-351472-ch004jxy 33 19 ( ( -LRB- cord-351472-ch004jxy 33 20 Figure figure NN cord-351472-ch004jxy 33 21 2 2 CD cord-351472-ch004jxy 33 22 ) ) -RRB- cord-351472-ch004jxy 33 23 . . . cord-351472-ch004jxy 34 1 125 125 CD cord-351472-ch004jxy 35 1 The the DT cord-351472-ch004jxy 35 2 existence existence NN cord-351472-ch004jxy 35 3 of of IN cord-351472-ch004jxy 35 4 B b NN cord-351472-ch004jxy 35 5 - - HYPH cord-351472-ch004jxy 35 6 cell cell NN cord-351472-ch004jxy 35 7 linear linear JJ cord-351472-ch004jxy 35 8 and and CC cord-351472-ch004jxy 35 9 discontinuous discontinuous JJ cord-351472-ch004jxy 35 10 ( ( -LRB- cord-351472-ch004jxy 35 11 conformational conformational JJ cord-351472-ch004jxy 35 12 ) ) -RRB- cord-351472-ch004jxy 35 13 epitopes epitope NNS cord-351472-ch004jxy 35 14 within within IN cord-351472-ch004jxy 35 15 the the DT cord-351472-ch004jxy 35 16 126 126 CD cord-351472-ch004jxy 35 17 identified identify VBN cord-351472-ch004jxy 35 18 segments segment NNS cord-351472-ch004jxy 35 19 could could MD cord-351472-ch004jxy 35 20 help help VB cord-351472-ch004jxy 35 21 us -PRON- PRP cord-351472-ch004jxy 35 22 to to TO cord-351472-ch004jxy 35 23 identify identify VB cord-351472-ch004jxy 35 24 the the DT cord-351472-ch004jxy 35 25 peptides peptide NNS cord-351472-ch004jxy 35 26 , , , cord-351472-ch004jxy 35 27 which which WDT cord-351472-ch004jxy 35 28 can can MD cord-351472-ch004jxy 35 29 elicit elicit VB cord-351472-ch004jxy 35 30 immune immune JJ cord-351472-ch004jxy 35 31 response response NN cord-351472-ch004jxy 35 32 127 127 CD cord-351472-ch004jxy 35 33 28 28 CD cord-351472-ch004jxy 35 34 . . . cord-351472-ch004jxy 36 1 We -PRON- PRP cord-351472-ch004jxy 36 2 identified identify VBD cord-351472-ch004jxy 36 3 18 18 CD cord-351472-ch004jxy 36 4 linear linear JJ cord-351472-ch004jxy 36 5 epitopes epitope NNS cord-351472-ch004jxy 36 6 , , , cord-351472-ch004jxy 36 7 predicted predict VBN cord-351472-ch004jxy 36 8 by by IN cord-351472-ch004jxy 36 9 ElliPro ElliPro NNP cord-351472-ch004jxy 36 10 ( ( -LRB- cord-351472-ch004jxy 36 11 IEDB IEDB NNP cord-351472-ch004jxy 36 12 ) ) -RRB- cord-351472-ch004jxy 36 13 , , , cord-351472-ch004jxy 36 14 which which WDT cord-351472-ch004jxy 36 15 contains contain VBZ cord-351472-ch004jxy 36 16 regions region NNS cord-351472-ch004jxy 36 17 from from IN cord-351472-ch004jxy 36 18 128 128 CD cord-351472-ch004jxy 36 19 19 19 CD cord-351472-ch004jxy 36 20 of of IN cord-351472-ch004jxy 36 21 our -PRON- PRP$ cord-351472-ch004jxy 36 22 selected select VBN cord-351472-ch004jxy 36 23 peptides peptide NNS cord-351472-ch004jxy 36 24 highlighted highlight VBN cord-351472-ch004jxy 36 25 in in IN cord-351472-ch004jxy 36 26 red red NN cord-351472-ch004jxy 36 27 in in IN cord-351472-ch004jxy 36 28 Table Table NNP cord-351472-ch004jxy 36 29 2 2 CD cord-351472-ch004jxy 36 30 . . . cord-351472-ch004jxy 37 1 These these DT cord-351472-ch004jxy 37 2 identified identify VBN cord-351472-ch004jxy 37 3 B b NN cord-351472-ch004jxy 37 4 - - HYPH cord-351472-ch004jxy 37 5 cell cell NN cord-351472-ch004jxy 37 6 linear linear JJ cord-351472-ch004jxy 37 7 epitopes epitope NNS cord-351472-ch004jxy 37 8 129 129 CD cord-351472-ch004jxy 37 9 are be VBP cord-351472-ch004jxy 37 10 placed place VBN cord-351472-ch004jxy 37 11 based base VBN cord-351472-ch004jxy 37 12 on on IN cord-351472-ch004jxy 37 13 their -PRON- PRP$ cord-351472-ch004jxy 37 14 positional positional JJ cord-351472-ch004jxy 37 15 value value NN cord-351472-ch004jxy 37 16 , , , cord-351472-ch004jxy 37 17 and and CC cord-351472-ch004jxy 37 18 scores score NNS cord-351472-ch004jxy 37 19 . . . cord-351472-ch004jxy 38 1 Epitopes epitope NNS cord-351472-ch004jxy 38 2 with with IN cord-351472-ch004jxy 38 3 high high JJ cord-351472-ch004jxy 38 4 scores score NNS cord-351472-ch004jxy 38 5 have have VBP cord-351472-ch004jxy 38 6 more more JJR cord-351472-ch004jxy 38 7 130 130 CD cord-351472-ch004jxy 38 8 potential potential NN cord-351472-ch004jxy 38 9 for for IN cord-351472-ch004jxy 38 10 antibody antibody NN cord-351472-ch004jxy 38 11 binding binding NN cord-351472-ch004jxy 38 12 . . . cord-351472-ch004jxy 39 1 Five five CD cord-351472-ch004jxy 39 2 of of IN cord-351472-ch004jxy 39 3 our -PRON- PRP$ cord-351472-ch004jxy 39 4 selected select VBN cord-351472-ch004jxy 39 5 peptides peptide NNS cord-351472-ch004jxy 39 6 ( ( -LRB- cord-351472-ch004jxy 39 7 peptide peptide NN cord-351472-ch004jxy 39 8 numbers number NNS cord-351472-ch004jxy 39 9 3 3 CD cord-351472-ch004jxy 39 10 , , , cord-351472-ch004jxy 39 11 5 5 CD cord-351472-ch004jxy 39 12 , , , cord-351472-ch004jxy 39 13 19 19 CD cord-351472-ch004jxy 39 14 , , , cord-351472-ch004jxy 39 15 23 23 CD cord-351472-ch004jxy 39 16 , , , cord-351472-ch004jxy 39 17 and and CC cord-351472-ch004jxy 39 18 131 131 CD cord-351472-ch004jxy 39 19 24 24 CD cord-351472-ch004jxy 39 20 in in IN cord-351472-ch004jxy 39 21 Table Table NNP cord-351472-ch004jxy 39 22 1 1 CD cord-351472-ch004jxy 39 23 ) ) -RRB- cord-351472-ch004jxy 39 24 were be VBD cord-351472-ch004jxy 39 25 not not RB cord-351472-ch004jxy 39 26 considered consider VBN cord-351472-ch004jxy 39 27 as as IN cord-351472-ch004jxy 39 28 potential potential JJ cord-351472-ch004jxy 39 29 linear linear JJ cord-351472-ch004jxy 39 30 B b NN cord-351472-ch004jxy 39 31 - - HYPH cord-351472-ch004jxy 39 32 cell cell NN cord-351472-ch004jxy 39 33 epitopes epitope NNS cord-351472-ch004jxy 39 34 . . . cord-351472-ch004jxy 40 1 Using use VBG cord-351472-ch004jxy 40 2 the the DT cord-351472-ch004jxy 40 3 same same JJ cord-351472-ch004jxy 40 4 module module NN cord-351472-ch004jxy 40 5 , , , cord-351472-ch004jxy 40 6 B b NN cord-351472-ch004jxy 40 7 - - HYPH cord-351472-ch004jxy 40 8 cell cell NN cord-351472-ch004jxy 40 9 discontinuous discontinuous JJ cord-351472-ch004jxy 40 10 epitopes epitope NNS cord-351472-ch004jxy 40 11 were be VBD cord-351472-ch004jxy 40 12 predicted predict VBN cord-351472-ch004jxy 40 13 , , , cord-351472-ch004jxy 40 14 which which WDT cord-351472-ch004jxy 40 15 gave give VBD cord-351472-ch004jxy 40 16 16 16 CD cord-351472-ch004jxy 40 17 133 133 CD cord-351472-ch004jxy 40 18 epitope epitope NN cord-351472-ch004jxy 40 19 regions region NNS cord-351472-ch004jxy 40 20 that that WDT cord-351472-ch004jxy 40 21 contained contain VBD cord-351472-ch004jxy 40 22 regions region NNS cord-351472-ch004jxy 40 23 from from IN cord-351472-ch004jxy 40 24 18 18 CD cord-351472-ch004jxy 40 25 of of IN cord-351472-ch004jxy 40 26 our -PRON- PRP$ cord-351472-ch004jxy 40 27 selected select VBN cord-351472-ch004jxy 40 28 peptides peptide NNS cord-351472-ch004jxy 40 29 highlighted highlight VBN cord-351472-ch004jxy 40 30 in in IN cord-351472-ch004jxy 40 31 red red JJ cord-351472-ch004jxy 40 32 134 134 CD cord-351472-ch004jxy 40 33 ( ( -LRB- cord-351472-ch004jxy 40 34 Table Table NNP cord-351472-ch004jxy 40 35 3 3 CD cord-351472-ch004jxy 40 36 ) ) -RRB- cord-351472-ch004jxy 40 37 . . . cord-351472-ch004jxy 41 1 Six six CD cord-351472-ch004jxy 41 2 peptides peptide NNS cord-351472-ch004jxy 41 3 ( ( -LRB- cord-351472-ch004jxy 41 4 peptide peptide NN cord-351472-ch004jxy 41 5 numbers number NNS cord-351472-ch004jxy 41 6 3 3 CD cord-351472-ch004jxy 41 7 , , , cord-351472-ch004jxy 41 8 5 5 CD cord-351472-ch004jxy 41 9 , , , cord-351472-ch004jxy 41 10 14 14 CD cord-351472-ch004jxy 41 11 , , , cord-351472-ch004jxy 41 12 19 19 CD cord-351472-ch004jxy 41 13 , , , cord-351472-ch004jxy 41 14 23 23 CD cord-351472-ch004jxy 41 15 , , , cord-351472-ch004jxy 41 16 and and CC cord-351472-ch004jxy 41 17 24 24 CD cord-351472-ch004jxy 41 18 in in IN cord-351472-ch004jxy 41 19 Table Table NNP cord-351472-ch004jxy 41 20 1 1 CD cord-351472-ch004jxy 41 21 ) ) -RRB- cord-351472-ch004jxy 41 22 were be VBD cord-351472-ch004jxy 41 23 not not RB cord-351472-ch004jxy 41 24 predicted predict VBN cord-351472-ch004jxy 41 25 135 135 CD cord-351472-ch004jxy 41 26 as as IN cord-351472-ch004jxy 41 27 discontinuous discontinuous JJ cord-351472-ch004jxy 41 28 B b NN cord-351472-ch004jxy 41 29 - - HYPH cord-351472-ch004jxy 41 30 cell cell NN cord-351472-ch004jxy 41 31 epitopes epitope NNS cord-351472-ch004jxy 41 32 . . . cord-351472-ch004jxy 42 1 To to TO cord-351472-ch004jxy 42 2 further further RB cord-351472-ch004jxy 42 3 confirm confirm VB cord-351472-ch004jxy 42 4 , , , cord-351472-ch004jxy 42 5 we -PRON- PRP cord-351472-ch004jxy 42 6 used use VBD cord-351472-ch004jxy 42 7 ABCpred abcpred JJ cord-351472-ch004jxy 42 8 server server NN cord-351472-ch004jxy 42 9 to to TO cord-351472-ch004jxy 42 10 detect detect VB cord-351472-ch004jxy 42 11 B b NN cord-351472-ch004jxy 42 12 - - HYPH cord-351472-ch004jxy 42 13 cell cell NN cord-351472-ch004jxy 42 14 136 136 CD cord-351472-ch004jxy 42 15 epitopes epitope NNS cord-351472-ch004jxy 42 16 , , , cord-351472-ch004jxy 42 17 with with IN cord-351472-ch004jxy 42 18 default default NN cord-351472-ch004jxy 42 19 threshold threshold NN cord-351472-ch004jxy 42 20 of of IN cord-351472-ch004jxy 42 21 0.51 0.51 CD cord-351472-ch004jxy 42 22 . . . cord-351472-ch004jxy 43 1 It -PRON- PRP cord-351472-ch004jxy 43 2 identified identify VBD cord-351472-ch004jxy 43 3 various various JJ cord-351472-ch004jxy 43 4 epitopes epitope NNS cord-351472-ch004jxy 43 5 with with IN cord-351472-ch004jxy 43 6 different different JJ cord-351472-ch004jxy 43 7 length length NN cord-351472-ch004jxy 43 8 and and CC cord-351472-ch004jxy 43 9 137 137 CD cord-351472-ch004jxy 43 10 scores score NNS cord-351472-ch004jxy 43 11 ; ; : cord-351472-ch004jxy 43 12 out out IN cord-351472-ch004jxy 43 13 of of IN cord-351472-ch004jxy 43 14 those those DT cord-351472-ch004jxy 43 15 , , , cord-351472-ch004jxy 43 16 the the DT cord-351472-ch004jxy 43 17 regions region NNS cord-351472-ch004jxy 43 18 which which WDT cord-351472-ch004jxy 43 19 contained contain VBD cord-351472-ch004jxy 43 20 our -PRON- PRP$ cord-351472-ch004jxy 43 21 selected select VBN cord-351472-ch004jxy 43 22 peptides peptide NNS cord-351472-ch004jxy 43 23 are be VBP cord-351472-ch004jxy 43 24 highlighted highlight VBN cord-351472-ch004jxy 43 25 in in IN cord-351472-ch004jxy 43 26 red red NN cord-351472-ch004jxy 43 27 138 138 CD cord-351472-ch004jxy 44 1 ( ( -LRB- cord-351472-ch004jxy 44 2 Table table NN cord-351472-ch004jxy 44 3 4 4 CD cord-351472-ch004jxy 44 4 ) ) -RRB- cord-351472-ch004jxy 44 5 . . . cord-351472-ch004jxy 45 1 A a DT cord-351472-ch004jxy 45 2 high high JJ cord-351472-ch004jxy 45 3 score score NN cord-351472-ch004jxy 45 4 represents represent VBZ cord-351472-ch004jxy 45 5 a a DT cord-351472-ch004jxy 45 6 good good JJ cord-351472-ch004jxy 45 7 binding bind VBG cord-351472-ch004jxy 45 8 affinity affinity NN cord-351472-ch004jxy 45 9 with with IN cord-351472-ch004jxy 45 10 epitopes epitope NNS cord-351472-ch004jxy 45 11 , , , cord-351472-ch004jxy 45 12 and and CC cord-351472-ch004jxy 45 13 most most JJS cord-351472-ch004jxy 45 14 of of IN cord-351472-ch004jxy 45 15 our -PRON- PRP$ cord-351472-ch004jxy 45 16 139 139 CD cord-351472-ch004jxy 45 17 peptides peptide NNS cord-351472-ch004jxy 45 18 scored score VBD cord-351472-ch004jxy 45 19 more more JJR cord-351472-ch004jxy 45 20 than than IN cord-351472-ch004jxy 45 21 0.7 0.7 CD cord-351472-ch004jxy 45 22 and and CC cord-351472-ch004jxy 45 23 were be VBD cord-351472-ch004jxy 45 24 predicted predict VBN cord-351472-ch004jxy 45 25 as as IN cord-351472-ch004jxy 45 26 linear linear NNP cord-351472-ch004jxy 45 27 B b NN cord-351472-ch004jxy 45 28 - - HYPH cord-351472-ch004jxy 45 29 cell cell NN cord-351472-ch004jxy 45 30 epitopes epitope NNS cord-351472-ch004jxy 45 31 . . . cord-351472-ch004jxy 46 1 140 140 CD cord-351472-ch004jxy 47 1 We -PRON- PRP cord-351472-ch004jxy 47 2 used use VBD cord-351472-ch004jxy 47 3 the the DT cord-351472-ch004jxy 47 4 IEDB IEDB NNP cord-351472-ch004jxy 47 5 server server NN cord-351472-ch004jxy 47 6 to to TO cord-351472-ch004jxy 47 7 determine determine VB cord-351472-ch004jxy 47 8 the the DT cord-351472-ch004jxy 47 9 binding bind VBG cord-351472-ch004jxy 47 10 affinity affinity NN cord-351472-ch004jxy 47 11 for for IN cord-351472-ch004jxy 47 12 human human JJ cord-351472-ch004jxy 47 13 leucocyte leucocyte NNP cord-351472-ch004jxy 47 14 antigen antigen NNP cord-351472-ch004jxy 47 15 141 141 CD cord-351472-ch004jxy 47 16 ( ( -LRB- cord-351472-ch004jxy 47 17 HLA HLA NNP cord-351472-ch004jxy 47 18 ) ) -RRB- cord-351472-ch004jxy 47 19 with with IN cord-351472-ch004jxy 47 20 our -PRON- PRP$ cord-351472-ch004jxy 47 21 selected select VBN cord-351472-ch004jxy 47 22 peptides peptide NNS cord-351472-ch004jxy 47 23 from from IN cord-351472-ch004jxy 47 24 Table table NN cord-351472-ch004jxy 47 25 1 1 CD cord-351472-ch004jxy 47 26 . . . cord-351472-ch004jxy 48 1 As as IN cord-351472-ch004jxy 48 2 recommended recommend VBN cord-351472-ch004jxy 48 3 by by IN cord-351472-ch004jxy 48 4 the the DT cord-351472-ch004jxy 48 5 IEDB IEDB NNP cord-351472-ch004jxy 48 6 server server NN cord-351472-ch004jxy 48 7 , , , cord-351472-ch004jxy 48 8 142 142 CD cord-351472-ch004jxy 48 9 reference reference NN cord-351472-ch004jxy 48 10 HLA HLA NNP cord-351472-ch004jxy 48 11 allele allele NN cord-351472-ch004jxy 48 12 sets set NNS cord-351472-ch004jxy 48 13 were be VBD cord-351472-ch004jxy 48 14 used use VBN cord-351472-ch004jxy 48 15 for for IN cord-351472-ch004jxy 48 16 the the DT cord-351472-ch004jxy 48 17 prediction prediction NN cord-351472-ch004jxy 48 18 of of IN cord-351472-ch004jxy 48 19 MHC MHC NNP cord-351472-ch004jxy 48 20 - - HYPH cord-351472-ch004jxy 48 21 I I NNP cord-351472-ch004jxy 48 22 and and CC cord-351472-ch004jxy 48 23 MHC MHC NNP cord-351472-ch004jxy 48 24 - - HYPH cord-351472-ch004jxy 48 25 II II NNP cord-351472-ch004jxy 48 26 T T NNP cord-351472-ch004jxy 48 27 - - HYPH cord-351472-ch004jxy 48 28 cell cell NN cord-351472-ch004jxy 48 29 epitopes epitope NNS cord-351472-ch004jxy 48 30 , , , cord-351472-ch004jxy 48 31 143 143 CD cord-351472-ch004jxy 48 32 as as IN cord-351472-ch004jxy 48 33 they -PRON- PRP cord-351472-ch004jxy 48 34 provide provide VBP cord-351472-ch004jxy 48 35 comprehensive comprehensive JJ cord-351472-ch004jxy 48 36 coverage coverage NN cord-351472-ch004jxy 48 37 of of IN cord-351472-ch004jxy 48 38 the the DT cord-351472-ch004jxy 48 39 population population NN cord-351472-ch004jxy 48 40 . . . cord-351472-ch004jxy 49 1 All all PDT cord-351472-ch004jxy 49 2 the the DT cord-351472-ch004jxy 49 3 predictions prediction NNS cord-351472-ch004jxy 49 4 were be VBD cord-351472-ch004jxy 49 5 made make VBN cord-351472-ch004jxy 49 6 using use VBG cord-351472-ch004jxy 49 7 144 144 CD cord-351472-ch004jxy 49 8 IEDB IEDB NNP cord-351472-ch004jxy 49 9 recommended recommend VBD cord-351472-ch004jxy 49 10 procedures procedure NNS cord-351472-ch004jxy 49 11 . . . cord-351472-ch004jxy 50 1 We -PRON- PRP cord-351472-ch004jxy 50 2 observed observe VBD cord-351472-ch004jxy 50 3 good good JJ cord-351472-ch004jxy 50 4 binding bind VBG cord-351472-ch004jxy 50 5 affinities affinity NNS cord-351472-ch004jxy 50 6 for for IN cord-351472-ch004jxy 50 7 our -PRON- PRP$ cord-351472-ch004jxy 50 8 selected select VBN cord-351472-ch004jxy 50 9 peptides peptide NNS cord-351472-ch004jxy 50 10 . . . cord-351472-ch004jxy 51 1 The the DT cord-351472-ch004jxy 51 2 list list NN cord-351472-ch004jxy 51 3 of of IN cord-351472-ch004jxy 51 4 binding bind VBG cord-351472-ch004jxy 51 5 affinities affinity NNS cord-351472-ch004jxy 51 6 for for IN cord-351472-ch004jxy 51 7 MHC MHC NNP cord-351472-ch004jxy 51 8 - - HYPH cord-351472-ch004jxy 51 9 I I NNP cord-351472-ch004jxy 51 10 T t NN cord-351472-ch004jxy 51 11 - - HYPH cord-351472-ch004jxy 51 12 cell cell NN cord-351472-ch004jxy 51 13 epitopes epitope NNS cord-351472-ch004jxy 51 14 is be VBZ cord-351472-ch004jxy 51 15 given give VBN cord-351472-ch004jxy 51 16 in in IN cord-351472-ch004jxy 51 17 Table Table NNP cord-351472-ch004jxy 51 18 5 5 CD cord-351472-ch004jxy 51 19 , , , cord-351472-ch004jxy 51 20 where where WRB cord-351472-ch004jxy 51 21 low low JJ cord-351472-ch004jxy 51 22 rank rank NN cord-351472-ch004jxy 51 23 146 146 CD cord-351472-ch004jxy 51 24 represents represent VBZ cord-351472-ch004jxy 51 25 high high JJ cord-351472-ch004jxy 51 26 binding bind VBG cord-351472-ch004jxy 51 27 affinity affinity NN cord-351472-ch004jxy 51 28 . . . cord-351472-ch004jxy 52 1 The the DT cord-351472-ch004jxy 52 2 epitopes epitope NNS cord-351472-ch004jxy 52 3 with with IN cord-351472-ch004jxy 52 4 rank rank NN cord-351472-ch004jxy 52 5 < < XX cord-351472-ch004jxy 52 6 1 1 CD cord-351472-ch004jxy 52 7 % % NN cord-351472-ch004jxy 52 8 for for IN cord-351472-ch004jxy 52 9 very very RB cord-351472-ch004jxy 52 10 high high JJ cord-351472-ch004jxy 52 11 binding bind VBG cord-351472-ch004jxy 52 12 affinity affinity NN cord-351472-ch004jxy 52 13 147 147 CD cord-351472-ch004jxy 52 14 were be VBD cord-351472-ch004jxy 52 15 selected select VBN cord-351472-ch004jxy 52 16 . . . cord-351472-ch004jxy 53 1 Regions region NNS cord-351472-ch004jxy 53 2 from from IN cord-351472-ch004jxy 53 3 all all DT cord-351472-ch004jxy 53 4 of of IN cord-351472-ch004jxy 53 5 our -PRON- PRP$ cord-351472-ch004jxy 53 6 selected select VBN cord-351472-ch004jxy 53 7 peptides peptide NNS cord-351472-ch004jxy 53 8 were be VBD cord-351472-ch004jxy 53 9 found find VBN cord-351472-ch004jxy 53 10 to to TO cord-351472-ch004jxy 53 11 be be VB cord-351472-ch004jxy 53 12 potential potential JJ cord-351472-ch004jxy 53 13 T t NN cord-351472-ch004jxy 53 14 - - HYPH cord-351472-ch004jxy 53 15 cell cell NN cord-351472-ch004jxy 53 16 7 7 CD cord-351472-ch004jxy 53 17 epitope(s epitope(s NNP cord-351472-ch004jxy 53 18 ) ) -RRB- cord-351472-ch004jxy 53 19 with with IN cord-351472-ch004jxy 53 20 high high JJ cord-351472-ch004jxy 53 21 binding binding NN cord-351472-ch004jxy 53 22 affinity affinity NN cord-351472-ch004jxy 53 23 with with IN cord-351472-ch004jxy 53 24 HLA HLA NNP cord-351472-ch004jxy 53 25 - - HYPH cord-351472-ch004jxy 53 26 A A NNP cord-351472-ch004jxy 53 27 and and CC cord-351472-ch004jxy 53 28 HLA HLA NNP cord-351472-ch004jxy 53 29 - - HYPH cord-351472-ch004jxy 53 30 B B NNP cord-351472-ch004jxy 53 31 alleles allele NNS cord-351472-ch004jxy 53 32 , , , cord-351472-ch004jxy 53 33 except except IN cord-351472-ch004jxy 53 34 one one CD cord-351472-ch004jxy 53 35 . . . cord-351472-ch004jxy 54 1 Similarly similarly RB cord-351472-ch004jxy 54 2 , , , cord-351472-ch004jxy 54 3 149 149 CD cord-351472-ch004jxy 54 4 the the DT cord-351472-ch004jxy 54 5 list list NN cord-351472-ch004jxy 54 6 of of IN cord-351472-ch004jxy 54 7 binding bind VBG cord-351472-ch004jxy 54 8 affinities affinity NNS cord-351472-ch004jxy 54 9 for for IN cord-351472-ch004jxy 54 10 MHC MHC NNP cord-351472-ch004jxy 54 11 - - HYPH cord-351472-ch004jxy 54 12 II II NNP cord-351472-ch004jxy 54 13 T T NNP cord-351472-ch004jxy 54 14 - - HYPH cord-351472-ch004jxy 54 15 cell cell NN cord-351472-ch004jxy 54 16 epitopes epitope NNS cord-351472-ch004jxy 54 17 are be VBP cord-351472-ch004jxy 54 18 given give VBN cord-351472-ch004jxy 54 19 in in IN cord-351472-ch004jxy 54 20 Table Table NNP cord-351472-ch004jxy 54 21 6 6 CD cord-351472-ch004jxy 54 22 . . . cord-351472-ch004jxy 55 1 Regions region NNS cord-351472-ch004jxy 55 2 from from IN cord-351472-ch004jxy 55 3 our -PRON- PRP$ cord-351472-ch004jxy 55 4 150 150 CD cord-351472-ch004jxy 55 5 selected select VBN cord-351472-ch004jxy 55 6 peptides peptide NNS cord-351472-ch004jxy 55 7 are be VBP cord-351472-ch004jxy 55 8 highlighted highlight VBN cord-351472-ch004jxy 55 9 in in IN cord-351472-ch004jxy 55 10 red red NN cord-351472-ch004jxy 55 11 . . . cord-351472-ch004jxy 56 1 The the DT cord-351472-ch004jxy 56 2 results result NNS cord-351472-ch004jxy 56 3 revealed reveal VBD cord-351472-ch004jxy 56 4 that that IN cord-351472-ch004jxy 56 5 around around IN cord-351472-ch004jxy 56 6 half half NN cord-351472-ch004jxy 56 7 of of IN cord-351472-ch004jxy 56 8 our -PRON- PRP$ cord-351472-ch004jxy 56 9 selected select VBN cord-351472-ch004jxy 56 10 151 151 CD cord-351472-ch004jxy 56 11 peptides peptide NNS cord-351472-ch004jxy 56 12 are be VBP cord-351472-ch004jxy 56 13 potential potential JJ cord-351472-ch004jxy 56 14 T t NN cord-351472-ch004jxy 56 15 - - HYPH cord-351472-ch004jxy 56 16 cell cell NN cord-351472-ch004jxy 56 17 epitope(s epitope(s NNP cord-351472-ch004jxy 56 18 ) ) -RRB- cord-351472-ch004jxy 56 19 with with IN cord-351472-ch004jxy 56 20 high high JJ cord-351472-ch004jxy 56 21 binding binding NN cord-351472-ch004jxy 56 22 affinity affinity NN cord-351472-ch004jxy 56 23 with with IN cord-351472-ch004jxy 56 24 HLA HLA NNP cord-351472-ch004jxy 56 25 - - HYPH cord-351472-ch004jxy 56 26 DRB DRB NNP cord-351472-ch004jxy 56 27 and and CC cord-351472-ch004jxy 56 28 HLA-152 HLA-152 NNP cord-351472-ch004jxy 56 29 DP DP NNP cord-351472-ch004jxy 56 30 / / SYM cord-351472-ch004jxy 56 31 DQ DQ NNP cord-351472-ch004jxy 56 32 alleles allele NNS cord-351472-ch004jxy 56 33 . . . cord-351472-ch004jxy 57 1 Overall overall RB cord-351472-ch004jxy 57 2 , , , cord-351472-ch004jxy 57 3 it -PRON- PRP cord-351472-ch004jxy 57 4 was be VBD cord-351472-ch004jxy 57 5 found find VBN cord-351472-ch004jxy 57 6 that that IN cord-351472-ch004jxy 57 7 the the DT cord-351472-ch004jxy 57 8 regions region NNS cord-351472-ch004jxy 57 9 identified identify VBN cord-351472-ch004jxy 57 10 in in IN cord-351472-ch004jxy 57 11 Table Table NNP cord-351472-ch004jxy 57 12 1 1 CD cord-351472-ch004jxy 57 13 not not RB cord-351472-ch004jxy 57 14 only only RB cord-351472-ch004jxy 57 15 had have VBD cord-351472-ch004jxy 57 16 good good JJ cord-351472-ch004jxy 57 17 B b NN cord-351472-ch004jxy 57 18 - - HYPH cord-351472-ch004jxy 57 19 cell cell NN cord-351472-ch004jxy 57 20 and and CC cord-351472-ch004jxy 57 21 154 154 CD cord-351472-ch004jxy 57 22 T t NN cord-351472-ch004jxy 57 23 - - HYPH cord-351472-ch004jxy 57 24 cell cell NN cord-351472-ch004jxy 57 25 affinities affinity NNS cord-351472-ch004jxy 57 26 , , , cord-351472-ch004jxy 57 27 but but CC cord-351472-ch004jxy 57 28 the the DT cord-351472-ch004jxy 57 29 majority majority NN cord-351472-ch004jxy 57 30 of of IN cord-351472-ch004jxy 57 31 them -PRON- PRP cord-351472-ch004jxy 57 32 had have VBD cord-351472-ch004jxy 57 33 overlaps overlap NNS cord-351472-ch004jxy 57 34 with with IN cord-351472-ch004jxy 57 35 discontinuous discontinuous JJ cord-351472-ch004jxy 57 36 epitopes epitope NNS cord-351472-ch004jxy 57 37 also also RB cord-351472-ch004jxy 57 38 ( ( -LRB- cord-351472-ch004jxy 57 39 Table table NN cord-351472-ch004jxy 57 40 _SP cord-351472-ch004jxy 57 41 155 155 CD cord-351472-ch004jxy 57 42 3 3 CD cord-351472-ch004jxy 57 43 ) ) -RRB- cord-351472-ch004jxy 57 44 . . . cord-351472-ch004jxy 58 1 The the DT cord-351472-ch004jxy 58 2 peptide peptide NN cord-351472-ch004jxy 58 3 segments segment NNS cord-351472-ch004jxy 58 4 identified identify VBN cord-351472-ch004jxy 58 5 from from IN cord-351472-ch004jxy 58 6 the the DT cord-351472-ch004jxy 58 7 set set NN cord-351472-ch004jxy 58 8 of of IN cord-351472-ch004jxy 58 9 98 98 CD cord-351472-ch004jxy 58 10 sequences sequence NNS cord-351472-ch004jxy 58 11 of of IN cord-351472-ch004jxy 58 12 the the DT cord-351472-ch004jxy 58 13 SARS SARS NNP cord-351472-ch004jxy 58 14 - - HYPH cord-351472-ch004jxy 58 15 CoV-2 CoV-2 NNP cord-351472-ch004jxy 58 16 S S NNP cord-351472-ch004jxy 58 17 156 156 CD cord-351472-ch004jxy 58 18 glycoprotein glycoprotein NN cord-351472-ch004jxy 58 19 appear appear VBP cord-351472-ch004jxy 58 20 to to TO cord-351472-ch004jxy 58 21 hold hold VB cord-351472-ch004jxy 58 22 reasonable reasonable JJ cord-351472-ch004jxy 58 23 potential potential NN cord-351472-ch004jxy 58 24 to to TO cord-351472-ch004jxy 58 25 act act VB cord-351472-ch004jxy 58 26 as as IN cord-351472-ch004jxy 58 27 immunogens immunogen NNS cord-351472-ch004jxy 58 28 . . . cord-351472-ch004jxy 59 1 Peptide peptide NN cord-351472-ch004jxy 59 2 - - HYPH cord-351472-ch004jxy 59 3 based base VBN cord-351472-ch004jxy 59 4 success success NN cord-351472-ch004jxy 59 5 36 36 CD cord-351472-ch004jxy 59 6 . . . cord-351472-ch004jxy 60 1 In in IN cord-351472-ch004jxy 60 2 our -PRON- PRP$ cord-351472-ch004jxy 60 3 study study NN cord-351472-ch004jxy 60 4 , , , cord-351472-ch004jxy 60 5 we -PRON- PRP cord-351472-ch004jxy 60 6 predicted predict VBD cord-351472-ch004jxy 60 7 both both DT cord-351472-ch004jxy 60 8 B b NN cord-351472-ch004jxy 60 9 - - HYPH cord-351472-ch004jxy 60 10 cell cell NN cord-351472-ch004jxy 60 11 and and CC cord-351472-ch004jxy 60 12 T t NN cord-351472-ch004jxy 60 13 - - HYPH cord-351472-ch004jxy 60 14 cell cell NN cord-351472-ch004jxy 60 15 epitopes epitope NNS cord-351472-ch004jxy 60 16 for for IN cord-351472-ch004jxy 60 17 conferring confer VBG cord-351472-ch004jxy 60 18 immunity immunity NN cord-351472-ch004jxy 60 19 172 172 CD cord-351472-ch004jxy 60 20 in in IN cord-351472-ch004jxy 60 21 different different JJ cord-351472-ch004jxy 60 22 ways way NNS cord-351472-ch004jxy 60 23 . . . cord-351472-ch004jxy 61 1 We -PRON- PRP cord-351472-ch004jxy 61 2 speculate speculate VBP cord-351472-ch004jxy 61 3 that that IN cord-351472-ch004jxy 61 4 the the DT cord-351472-ch004jxy 61 5 identified identify VBN cord-351472-ch004jxy 61 6 epitopes epitope NNS cord-351472-ch004jxy 61 7 with with IN cord-351472-ch004jxy 61 8 considerably considerably RB cord-351472-ch004jxy 61 9 good good JJ cord-351472-ch004jxy 61 10 epitope epitope NN cord-351472-ch004jxy 61 11 8 8 CD cord-351472-ch004jxy 61 12 binding binding NN cord-351472-ch004jxy 61 13 efficiency efficiency NN cord-351472-ch004jxy 61 14 have have VBP cord-351472-ch004jxy 61 15 the the DT cord-351472-ch004jxy 61 16 potential potential NN cord-351472-ch004jxy 61 17 to to TO cord-351472-ch004jxy 61 18 be be VB cord-351472-ch004jxy 61 19 an an DT cord-351472-ch004jxy 61 20 immunodominant immunodominant JJ cord-351472-ch004jxy 61 21 peptide peptide NN cord-351472-ch004jxy 61 22 . . . cord-351472-ch004jxy 62 1 Peptide peptide NN cord-351472-ch004jxy 62 2 - - HYPH cord-351472-ch004jxy 62 3 based base VBN cord-351472-ch004jxy 62 4 174 174 CD cord-351472-ch004jxy 62 5 sensitive sensitive JJ cord-351472-ch004jxy 62 6 and and CC cord-351472-ch004jxy 62 7 rapid rapid JJ cord-351472-ch004jxy 62 8 diagnostic diagnostic JJ cord-351472-ch004jxy 62 9 kits kit NNS cord-351472-ch004jxy 62 10 are be VBP cord-351472-ch004jxy 62 11 considered consider VBN cord-351472-ch004jxy 62 12 as as IN cord-351472-ch004jxy 62 13 a a DT cord-351472-ch004jxy 62 14 better well JJR cord-351472-ch004jxy 62 15 alternative alternative NN cord-351472-ch004jxy 62 16 to to IN cord-351472-ch004jxy 62 17 the the DT cord-351472-ch004jxy 62 18 conventional conventional JJ cord-351472-ch004jxy 62 19 175 175 CD cord-351472-ch004jxy 62 20 serological serological JJ cord-351472-ch004jxy 62 21 tests test NNS cord-351472-ch004jxy 62 22 including include VBG cord-351472-ch004jxy 62 23 whole whole JJ cord-351472-ch004jxy 62 24 antigenic antigenic JJ cord-351472-ch004jxy 62 25 protein protein NN cord-351472-ch004jxy 62 26 13 13 CD cord-351472-ch004jxy 62 27 . . . cord-351472-ch004jxy 63 1 The the DT cord-351472-ch004jxy 63 2 study study NN cord-351472-ch004jxy 63 3 could could MD cord-351472-ch004jxy 63 4 help help VB cord-351472-ch004jxy 63 5 us -PRON- PRP cord-351472-ch004jxy 63 6 to to TO cord-351472-ch004jxy 63 7 use use VB cord-351472-ch004jxy 63 8 the the DT cord-351472-ch004jxy 63 9 176 176 CD cord-351472-ch004jxy 63 10 predicted predict VBN cord-351472-ch004jxy 63 11 peptide peptide NN cord-351472-ch004jxy 63 12 as as IN cord-351472-ch004jxy 63 13 an an DT cord-351472-ch004jxy 63 14 immunogen immunogen NN cord-351472-ch004jxy 63 15 for for IN cord-351472-ch004jxy 63 16 the the DT cord-351472-ch004jxy 63 17 development development NN cord-351472-ch004jxy 63 18 of of IN cord-351472-ch004jxy 63 19 diagnostics diagnostic NNS cord-351472-ch004jxy 63 20 against against IN cord-351472-ch004jxy 63 21 SARS SARS NNP cord-351472-ch004jxy 63 22 - - HYPH cord-351472-ch004jxy 63 23 CoV-2 CoV-2 NNP cord-351472-ch004jxy 63 24 . . . cord-351472-ch004jxy 64 1 Figure figure NN cord-351472-ch004jxy 64 2 3 3 CD cord-351472-ch004jxy 64 3 . . . cord-351472-ch004jxy 65 1 Table table NN cord-351472-ch004jxy 65 2 3 3 CD cord-351472-ch004jxy 65 3 . . . cord-351472-ch004jxy 66 1 IEDB IEDB NNP cord-351472-ch004jxy 66 2 ElliPro ElliPro NNP cord-351472-ch004jxy 66 3 predicted predict VBD cord-351472-ch004jxy 66 4 discontinuous discontinuous JJ cord-351472-ch004jxy 66 5 epitopes epitope NNS cord-351472-ch004jxy 66 6 for for IN cord-351472-ch004jxy 66 7 spike spike NN cord-351472-ch004jxy 66 8 protein protein NN cord-351472-ch004jxy 66 9 of of IN cord-351472-ch004jxy 66 10 SARS SARS NNP cord-351472-ch004jxy 66 11 - - HYPH cord-351472-ch004jxy 66 12 CoV-2 CoV-2 NNP cord-351472-ch004jxy 66 13 . . . cord-351472-ch004jxy 67 1 Sequences sequence NNS cord-351472-ch004jxy 67 2 that that WDT cord-351472-ch004jxy 67 3 match match VBP cord-351472-ch004jxy 67 4 our -PRON- PRP$ cord-351472-ch004jxy 67 5 selected select VBN cord-351472-ch004jxy 67 6 peptides peptide NNS cord-351472-ch004jxy 67 7 are be VBP cord-351472-ch004jxy 67 8 marked mark VBN cord-351472-ch004jxy 67 9 in in IN cord-351472-ch004jxy 67 10 red red NN cord-351472-ch004jxy 67 11 . . . cord-351472-ch004jxy 68 1 Table table NN cord-351472-ch004jxy 68 2 5 5 CD cord-351472-ch004jxy 68 3 . . . cord-351472-ch004jxy 69 1 IEDB IEDB NNP cord-351472-ch004jxy 69 2 prediction prediction NN cord-351472-ch004jxy 69 3 of of IN cord-351472-ch004jxy 69 4 binding bind VBG cord-351472-ch004jxy 69 5 affinity affinity NN cord-351472-ch004jxy 69 6 with with IN cord-351472-ch004jxy 69 7 MHC MHC NNP cord-351472-ch004jxy 69 8 - - : cord-351472-ch004jxy 69 9 I -PRON- PRP cord-351472-ch004jxy 69 10 alleles allele NNS cord-351472-ch004jxy 69 11 , , , cord-351472-ch004jxy 69 12 only only RB cord-351472-ch004jxy 69 13 our -PRON- PRP$ cord-351472-ch004jxy 69 14 selected select VBN cord-351472-ch004jxy 69 15 peptides peptide NNS cord-351472-ch004jxy 69 16 with with IN cord-351472-ch004jxy 69 17 percentile percentile JJ cord-351472-ch004jxy 69 18 rank rank NN cord-351472-ch004jxy 69 19 less less JJR cord-351472-ch004jxy 69 20 than than IN cord-351472-ch004jxy 69 21 1.00 1.00 CD cord-351472-ch004jxy 69 22 are be VBP cord-351472-ch004jxy 69 23 shown show VBN cord-351472-ch004jxy 69 24 here here RB cord-351472-ch004jxy 69 25 . . . cord-351472-ch004jxy 70 1 The the DT cord-351472-ch004jxy 70 2 binding bind VBG cord-351472-ch004jxy 70 3 affinity affinity NN cord-351472-ch004jxy 70 4 is be VBZ cord-351472-ch004jxy 70 5 considered consider VBN cord-351472-ch004jxy 70 6 higher high JJR cord-351472-ch004jxy 70 7 for for IN cord-351472-ch004jxy 70 8 low low JJ cord-351472-ch004jxy 70 9 percentile percentile JJ cord-351472-ch004jxy 70 10 rank rank NN cord-351472-ch004jxy 70 11 . . . cord-351472-ch004jxy 71 1 Sequences sequence NNS cord-351472-ch004jxy 71 2 that that WDT cord-351472-ch004jxy 71 3 match match VBP cord-351472-ch004jxy 71 4 our -PRON- PRP$ cord-351472-ch004jxy 71 5 selected select VBN cord-351472-ch004jxy 71 6 peptides peptide NNS cord-351472-ch004jxy 71 7 are be VBP cord-351472-ch004jxy 71 8 marked mark VBN cord-351472-ch004jxy 71 9 in in IN cord-351472-ch004jxy 71 10 red red NN cord-351472-ch004jxy 71 11 . . . cord-351472-ch004jxy 71 12 _SP cord-351472-ch004jxy 72 1 T1105 T1105 NNP cord-351472-ch004jxy 72 2 , , , cord-351472-ch004jxy 73 1 B b NN cord-351472-ch004jxy 73 2 : : : cord-351472-ch004jxy 74 1 Q1106 Q1106 NNP cord-351472-ch004jxy 74 2 , , , cord-351472-ch004jxy 74 3 B b NN cord-351472-ch004jxy 74 4 : : : cord-351472-ch004jxy 74 5 R1107 R1107 NNP cord-351472-ch004jxy 74 6 , , , cord-351472-ch004jxy 74 7 B b NN cord-351472-ch004jxy 74 8 : : : cord-351472-ch004jxy 75 1 N1108 N1108 NNP cord-351472-ch004jxy 75 2 , , , cord-351472-ch004jxy 76 1 B b NN cord-351472-ch004jxy 76 2 : : : cord-351472-ch004jxy 76 3 F1109 F1109 NNP cord-351472-ch004jxy 76 4 , , , cord-351472-ch004jxy 76 5 B b NN cord-351472-ch004jxy 76 6 : : : cord-351472-ch004jxy 76 7 Y1110 Y1110 NNP cord-351472-ch004jxy 76 8 , , , cord-351472-ch004jxy 77 1 B b NN cord-351472-ch004jxy 77 2 : : : cord-351472-ch004jxy 78 1 E1111 E1111 NNP cord-351472-ch004jxy 78 2 , , , cord-351472-ch004jxy 78 3 B b NN cord-351472-ch004jxy 78 4 : : : cord-351472-ch004jxy 78 5 P1112 P1112 NNP cord-351472-ch004jxy 78 6 , , , cord-351472-ch004jxy 78 7 B b NN cord-351472-ch004jxy 78 8 : : : cord-351472-ch004jxy 78 9 Q1113 Q1113 NNP cord-351472-ch004jxy 78 10 , , , cord-351472-ch004jxy 78 11 B b NN cord-351472-ch004jxy 78 12 : : : cord-351472-ch004jxy 78 13 I1114 I1114 NNP cord-351472-ch004jxy 78 14 , , , cord-351472-ch004jxy 78 15 B b NN cord-351472-ch004jxy 78 16 : : : cord-351472-ch004jxy 78 17 I1115 I1115 NNP cord-351472-ch004jxy 78 18 , , , cord-351472-ch004jxy 78 19 B b NN cord-351472-ch004jxy 78 20 : : : cord-351472-ch004jxy 79 1 T1116 T1116 NNP cord-351472-ch004jxy 79 2 , , , cord-351472-ch004jxy 79 3 B b NN cord-351472-ch004jxy 79 4 : : : cord-351472-ch004jxy 80 1 T1117 T1117 NNP cord-351472-ch004jxy 80 2 , , , cord-351472-ch004jxy 80 3 B b NN cord-351472-ch004jxy 80 4 : : : cord-351472-ch004jxy 81 1 D1118 D1118 NNP cord-351472-ch004jxy 81 2 , , , cord-351472-ch004jxy 81 3 B b NN cord-351472-ch004jxy 81 4 : : : cord-351472-ch004jxy 81 5 N1119 N1119 NNP cord-351472-ch004jxy 81 6 , , , cord-351472-ch004jxy 81 7 B b NN cord-351472-ch004jxy 81 8 : : : cord-351472-ch004jxy 81 9 T1120 T1120 NNP cord-351472-ch004jxy 81 10 , , , cord-351472-ch004jxy 81 11 B b NN cord-351472-ch004jxy 81 12 : : : cord-351472-ch004jxy 81 13 F1121 F1121 NNP cord-351472-ch004jxy 81 14 , , , cord-351472-ch004jxy 82 1 B b NN cord-351472-ch004jxy 82 2 : : : cord-351472-ch004jxy 82 3 V1122 v1122 UH cord-351472-ch004jxy 82 4 , , , cord-351472-ch004jxy 82 5 B b NN cord-351472-ch004jxy 82 6 : : : cord-351472-ch004jxy 82 7 S1123 s1123 NN cord-351472-ch004jxy 82 8 , , , cord-351472-ch004jxy 83 1 B b NN cord-351472-ch004jxy 83 2 : : : cord-351472-ch004jxy 83 3 G1124 G1124 NNP cord-351472-ch004jxy 83 4 , , , cord-351472-ch004jxy 84 1 B b NN cord-351472-ch004jxy 84 2 : : : cord-351472-ch004jxy 84 3 N1125 N1125 NNP cord-351472-ch004jxy 84 4 , , , cord-351472-ch004jxy 84 5 B b NN cord-351472-ch004jxy 84 6 : : : cord-351472-ch004jxy 85 1 C1126 C1126 NNP cord-351472-ch004jxy 85 2 , , , cord-351472-ch004jxy 85 3 B b NN cord-351472-ch004jxy 85 4 : : : cord-351472-ch004jxy 85 5 D1127 D1127 NNP cord-351472-ch004jxy 85 6 , , , cord-351472-ch004jxy 85 7 B b NN cord-351472-ch004jxy 85 8 : : : cord-351472-ch004jxy 85 9 V1128 v1128 NN cord-351472-ch004jxy 85 10 , , , cord-351472-ch004jxy 85 11 B b NN cord-351472-ch004jxy 85 12 : : : cord-351472-ch004jxy 85 13 V1129 V1129 NNP cord-351472-ch004jxy 85 14 , , , cord-351472-ch004jxy 86 1 B b NN cord-351472-ch004jxy 86 2 : : : cord-351472-ch004jxy 87 1 I1130 I1130 NNP cord-351472-ch004jxy 88 1 , , , cord-351472-ch004jxy 88 2 B b NN cord-351472-ch004jxy 88 3 : : : cord-351472-ch004jxy 88 4 G1131 G1131 NNP cord-351472-ch004jxy 88 5 , , , cord-351472-ch004jxy 88 6 B b NN cord-351472-ch004jxy 88 7 : : : cord-351472-ch004jxy 89 1 I1132 I1132 NNP cord-351472-ch004jxy 89 2 , , , cord-351472-ch004jxy 89 3 B b NN cord-351472-ch004jxy 89 4 : : : cord-351472-ch004jxy 90 1 V1133 V1133 NNP cord-351472-ch004jxy 90 2 , , , cord-351472-ch004jxy 90 3 B b NN cord-351472-ch004jxy 90 4 : : : cord-351472-ch004jxy 90 5 N1134 n1134 NN cord-351472-ch004jxy 90 6 , , , cord-351472-ch004jxy 90 7 B b NN cord-351472-ch004jxy 90 8 : : : cord-351472-ch004jxy 90 9 N1135 n1135 NN cord-351472-ch004jxy 90 10 , , , cord-351472-ch004jxy 90 11 B b NN cord-351472-ch004jxy 90 12 : : : cord-351472-ch004jxy 91 1 T1136 T1136 NNP cord-351472-ch004jxy 91 2 , , , cord-351472-ch004jxy 91 3 B b NN cord-351472-ch004jxy 91 4 : : : cord-351472-ch004jxy 91 5 V1137 V1137 NNP cord-351472-ch004jxy 91 6 , , , cord-351472-ch004jxy 92 1 B b NN cord-351472-ch004jxy 92 2 : : : cord-351472-ch004jxy 93 1 Y1138 Y1138 NNP cord-351472-ch004jxy 93 2 C C NNP cord-351472-ch004jxy 93 3 : : : cord-351472-ch004jxy 93 4 A1087 a1087 NN cord-351472-ch004jxy 93 5 , , , cord-351472-ch004jxy 93 6 C c NN cord-351472-ch004jxy 93 7 : : : cord-351472-ch004jxy 93 8 H1088 H1088 NNP cord-351472-ch004jxy 93 9 , , , cord-351472-ch004jxy 93 10 C c NN cord-351472-ch004jxy 93 11 : : : cord-351472-ch004jxy 93 12 F1089 f1089 NN cord-351472-ch004jxy 93 13 , , , cord-351472-ch004jxy 93 14 C c NN cord-351472-ch004jxy 93 15 : : : cord-351472-ch004jxy 93 16 P1090 P1090 NNP cord-351472-ch004jxy 93 17 , , , cord-351472-ch004jxy 93 18 C C NNP cord-351472-ch004jxy 93 19 : : : cord-351472-ch004jxy 93 20 R1091 R1091 NNP cord-351472-ch004jxy 93 21 , , , cord-351472-ch004jxy 93 22 C c NN cord-351472-ch004jxy 93 23 : : : cord-351472-ch004jxy 93 24 E1092 E1092 NNP cord-351472-ch004jxy 93 25 , , , cord-351472-ch004jxy 93 26 C C NNP cord-351472-ch004jxy 93 27 : : : cord-351472-ch004jxy 93 28 G1093 G1093 NNP cord-351472-ch004jxy 93 29 , , , cord-351472-ch004jxy 93 30 C c NN cord-351472-ch004jxy 93 31 : : : cord-351472-ch004jxy 93 32 V1094 V1094 NNP cord-351472-ch004jxy 93 33 , , , cord-351472-ch004jxy 93 34 C C NNP cord-351472-ch004jxy 93 35 : : : cord-351472-ch004jxy 93 36 F1095 F1095 NNP cord-351472-ch004jxy 94 1 , , , cord-351472-ch004jxy 94 2 C C NNP cord-351472-ch004jxy 94 3 : : : cord-351472-ch004jxy 95 1 V1096 V1096 NNP cord-351472-ch004jxy 95 2 , , , cord-351472-ch004jxy 95 3 C c NN cord-351472-ch004jxy 95 4 : : : cord-351472-ch004jxy 95 5 S1097 s1097 NN cord-351472-ch004jxy 95 6 , , , cord-351472-ch004jxy 95 7 C c NN cord-351472-ch004jxy 95 8 : : : cord-351472-ch004jxy 95 9 N1098 N1098 NNP cord-351472-ch004jxy 95 10 , , , cord-351472-ch004jxy 95 11 C c NN cord-351472-ch004jxy 95 12 : : : cord-351472-ch004jxy 95 13 G1099 G1099 NNP cord-351472-ch004jxy 95 14 , , , cord-351472-ch004jxy 95 15 C c NN cord-351472-ch004jxy 95 16 : : : cord-351472-ch004jxy 96 1 T1100 T1100 NNP cord-351472-ch004jxy 97 1 , , , cord-351472-ch004jxy 97 2 C C NNP cord-351472-ch004jxy 97 3 : : : cord-351472-ch004jxy 97 4 H1101 H1101 NNP cord-351472-ch004jxy 97 5 , , , cord-351472-ch004jxy 97 6 C c NN cord-351472-ch004jxy 97 7 : : : cord-351472-ch004jxy 98 1 W1102 W1102 NNP cord-351472-ch004jxy 98 2 , , , cord-351472-ch004jxy 98 3 C c NN cord-351472-ch004jxy 98 4 : : : cord-351472-ch004jxy 98 5 F1103 F1103 NNP cord-351472-ch004jxy 98 6 , , , cord-351472-ch004jxy 98 7 C c NN cord-351472-ch004jxy 98 8 : : : cord-351472-ch004jxy 98 9 V1104 V1104 NNP cord-351472-ch004jxy 98 10 , , , cord-351472-ch004jxy 99 1 C C NNP cord-351472-ch004jxy 99 2 : : : cord-351472-ch004jxy 99 3 T1105 T1105 NNP cord-351472-ch004jxy 100 1 , , , cord-351472-ch004jxy 100 2 C C NNP cord-351472-ch004jxy 100 3 : : : cord-351472-ch004jxy 100 4 Q1106 Q1106 NNP cord-351472-ch004jxy 100 5 , , , cord-351472-ch004jxy 100 6 C C NNP cord-351472-ch004jxy 100 7 : : : cord-351472-ch004jxy 100 8 R1107 R1107 NNP cord-351472-ch004jxy 100 9 , , , cord-351472-ch004jxy 100 10 C c NN cord-351472-ch004jxy 100 11 : : : cord-351472-ch004jxy 101 1 N1108 N1108 NNP cord-351472-ch004jxy 102 1 , , , cord-351472-ch004jxy 102 2 C C NNP cord-351472-ch004jxy 102 3 : : : cord-351472-ch004jxy 102 4 F1109 F1109 NNP cord-351472-ch004jxy 102 5 , , , cord-351472-ch004jxy 102 6 C C NNP cord-351472-ch004jxy 102 7 : : : cord-351472-ch004jxy 102 8 Y1110 Y1110 NNP cord-351472-ch004jxy 102 9 , , , cord-351472-ch004jxy 102 10 C C NNP cord-351472-ch004jxy 102 11 : : : cord-351472-ch004jxy 102 12 E1111 E1111 NNP cord-351472-ch004jxy 102 13 , , , cord-351472-ch004jxy 102 14 C c NN cord-351472-ch004jxy 102 15 : : : cord-351472-ch004jxy 102 16 P1112 P1112 NNP cord-351472-ch004jxy 102 17 , , , cord-351472-ch004jxy 102 18 C c NN cord-351472-ch004jxy 102 19 : : : cord-351472-ch004jxy 102 20 Q1113 Q1113 NNP cord-351472-ch004jxy 102 21 , , , cord-351472-ch004jxy 102 22 C c NN cord-351472-ch004jxy 102 23 : : : cord-351472-ch004jxy 102 24 I1114 I1114 NNP cord-351472-ch004jxy 102 25 , , , cord-351472-ch004jxy 102 26 C C NNP cord-351472-ch004jxy 102 27 : : : cord-351472-ch004jxy 102 28 I1115 I1115 NNP cord-351472-ch004jxy 102 29 , , , cord-351472-ch004jxy 102 30 C C NNP cord-351472-ch004jxy 102 31 : : : cord-351472-ch004jxy 102 32 T1116 T1116 NNP cord-351472-ch004jxy 102 33 , , , cord-351472-ch004jxy 102 34 C c NN cord-351472-ch004jxy 102 35 : : : cord-351472-ch004jxy 103 1 T1117 T1117 NNP cord-351472-ch004jxy 103 2 , , , cord-351472-ch004jxy 103 3 C c NN cord-351472-ch004jxy 103 4 : : : cord-351472-ch004jxy 103 5 D1118 D1118 NNP cord-351472-ch004jxy 103 6 , , , cord-351472-ch004jxy 103 7 C c NN cord-351472-ch004jxy 103 8 : : : cord-351472-ch004jxy 103 9 N1119 N1119 NNP cord-351472-ch004jxy 103 10 , , , cord-351472-ch004jxy 103 11 C c NN cord-351472-ch004jxy 103 12 : : : cord-351472-ch004jxy 103 13 T1120 T1120 NNP cord-351472-ch004jxy 103 14 , , , cord-351472-ch004jxy 103 15 C c NN cord-351472-ch004jxy 103 16 : : : cord-351472-ch004jxy 103 17 F1121 F1121 NNP cord-351472-ch004jxy 103 18 , , , cord-351472-ch004jxy 103 19 C c NN cord-351472-ch004jxy 103 20 : : : cord-351472-ch004jxy 103 21 V1122 v1122 UH cord-351472-ch004jxy 103 22 , , , cord-351472-ch004jxy 103 23 C c NN cord-351472-ch004jxy 103 24 : : : cord-351472-ch004jxy 103 25 S1123 S1123 NNP cord-351472-ch004jxy 103 26 , , , cord-351472-ch004jxy 103 27 C c NN cord-351472-ch004jxy 103 28 : : : cord-351472-ch004jxy 103 29 G1124 G1124 NNP cord-351472-ch004jxy 103 30 , , , cord-351472-ch004jxy 103 31 C c NN cord-351472-ch004jxy 103 32 : : : cord-351472-ch004jxy 103 33 N1125 N1125 NNP cord-351472-ch004jxy 103 34 , , , cord-351472-ch004jxy 103 35 C c NN cord-351472-ch004jxy 103 36 : : : cord-351472-ch004jxy 103 37 C1126 C1126 NNP cord-351472-ch004jxy 103 38 , , , cord-351472-ch004jxy 103 39 C c NN cord-351472-ch004jxy 103 40 : : : cord-351472-ch004jxy 104 1 D1127 D1127 NNP cord-351472-ch004jxy 104 2 , , , cord-351472-ch004jxy 104 3 C C NNP cord-351472-ch004jxy 104 4 : : : cord-351472-ch004jxy 104 5 V1128 v1128 NN cord-351472-ch004jxy 104 6 , , , cord-351472-ch004jxy 104 7 C c NN cord-351472-ch004jxy 104 8 : : : cord-351472-ch004jxy 104 9 V1129 V1129 NNP cord-351472-ch004jxy 104 10 , , , cord-351472-ch004jxy 104 11 C c NN cord-351472-ch004jxy 104 12 : : : cord-351472-ch004jxy 105 1 I1130 I1130 NNP cord-351472-ch004jxy 105 2 _SP cord-351472-ch004jxy 106 1 Table table NN cord-351472-ch004jxy 106 2 6 6 CD cord-351472-ch004jxy 106 3 . . . cord-351472-ch004jxy 107 1 IEDB IEDB NNP cord-351472-ch004jxy 107 2 prediction prediction NN cord-351472-ch004jxy 107 3 of of IN cord-351472-ch004jxy 107 4 binding bind VBG cord-351472-ch004jxy 107 5 affinity affinity NN cord-351472-ch004jxy 107 6 with with IN cord-351472-ch004jxy 107 7 MHC MHC NNP cord-351472-ch004jxy 107 8 - - HYPH cord-351472-ch004jxy 107 9 II II NNP cord-351472-ch004jxy 107 10 alleles allele NNS cord-351472-ch004jxy 107 11 , , , cord-351472-ch004jxy 107 12 only only RB cord-351472-ch004jxy 107 13 our -PRON- PRP$ cord-351472-ch004jxy 107 14 selected select VBN cord-351472-ch004jxy 107 15 peptides peptide NNS cord-351472-ch004jxy 107 16 with with IN cord-351472-ch004jxy 107 17 percentile percentile JJ cord-351472-ch004jxy 107 18 rank rank NN cord-351472-ch004jxy 107 19 less less JJR cord-351472-ch004jxy 107 20 than than IN cord-351472-ch004jxy 107 21 1.00 1.00 CD cord-351472-ch004jxy 107 22 are be VBP cord-351472-ch004jxy 107 23 shown show VBN cord-351472-ch004jxy 107 24 here here RB cord-351472-ch004jxy 107 25 . . . cord-351472-ch004jxy 108 1 The the DT cord-351472-ch004jxy 108 2 binding bind VBG cord-351472-ch004jxy 108 3 affinity affinity NN cord-351472-ch004jxy 108 4 is be VBZ cord-351472-ch004jxy 108 5 considered consider VBN cord-351472-ch004jxy 108 6 higher high JJR cord-351472-ch004jxy 108 7 for for IN cord-351472-ch004jxy 108 8 low low JJ cord-351472-ch004jxy 108 9 percentile percentile JJ cord-351472-ch004jxy 108 10 rank rank NN cord-351472-ch004jxy 108 11 . . . cord-351472-ch004jxy 109 1 Sequences sequence NNS cord-351472-ch004jxy 109 2 that that WDT cord-351472-ch004jxy 109 3 match match VBP cord-351472-ch004jxy 109 4 our -PRON- PRP$ cord-351472-ch004jxy 109 5 selected select VBN cord-351472-ch004jxy 109 6 peptides peptide NNS cord-351472-ch004jxy 109 7 are be VBP cord-351472-ch004jxy 109 8 marked mark VBN cord-351472-ch004jxy 109 9 in in IN cord-351472-ch004jxy 109 10 red red NN cord-351472-ch004jxy 109 11 . . . cord-351472-ch004jxy 109 12 _SP