id	sid	tid	token	lemma	pos
cord-329840-f3dsu36p	1	1	key	key	NN
cord-329840-f3dsu36p	1	2	:	:	:
cord-329840-f3dsu36p	2	1	cord-329840-f3dsu36p	cord-329840-f3dsu36p	NNP
cord-329840-f3dsu36p	2	2	authors	author	NNS
cord-329840-f3dsu36p	2	3	:	:	:
cord-329840-f3dsu36p	2	4	Hati	Hati	NNP
cord-329840-f3dsu36p	2	5	,	,	,
cord-329840-f3dsu36p	2	6	Sanchita	Sanchita	NNP
cord-329840-f3dsu36p	2	7	;	;	:
cord-329840-f3dsu36p	2	8	Bhattacharyya	Bhattacharyya	NNP
cord-329840-f3dsu36p	2	9	,	,	,
cord-329840-f3dsu36p	2	10	Sudeep	Sudeep	NNP
cord-329840-f3dsu36p	2	11	title	title	NN
cord-329840-f3dsu36p	2	12	:	:	:
cord-329840-f3dsu36p	2	13	Impact	impact	NN
cord-329840-f3dsu36p	2	14	of	of	IN
cord-329840-f3dsu36p	2	15	Thiol	Thiol	NNP
cord-329840-f3dsu36p	2	16	-	-	HYPH
cord-329840-f3dsu36p	2	17	Disulfide	Disulfide	NNP
cord-329840-f3dsu36p	2	18	Balance	Balance	NNP
cord-329840-f3dsu36p	2	19	on	on	IN
cord-329840-f3dsu36p	2	20	the	the	DT
cord-329840-f3dsu36p	2	21	Binding	Binding	NNP
cord-329840-f3dsu36p	2	22	of	of	IN
cord-329840-f3dsu36p	2	23	Covid-19	Covid-19	NNP
cord-329840-f3dsu36p	2	24	Spike	Spike	NNP
cord-329840-f3dsu36p	2	25	Protein	Protein	NNP
cord-329840-f3dsu36p	2	26	with	with	IN
cord-329840-f3dsu36p	2	27	Angiotensin	Angiotensin	NNP
cord-329840-f3dsu36p	2	28	Converting	Converting	NNP
cord-329840-f3dsu36p	2	29	Enzyme	Enzyme	NNP
cord-329840-f3dsu36p	2	30	2	2	CD
cord-329840-f3dsu36p	2	31	Receptor	Receptor	NNP
cord-329840-f3dsu36p	2	32	date	date	NN
cord-329840-f3dsu36p	2	33	:	:	:
cord-329840-f3dsu36p	2	34	2020	2020	CD
cord-329840-f3dsu36p	2	35	-	-	HYPH
cord-329840-f3dsu36p	2	36	05	05	CD
cord-329840-f3dsu36p	2	37	-	-	HYPH
cord-329840-f3dsu36p	2	38	11	11	CD
cord-329840-f3dsu36p	2	39	journal	journal	NN
cord-329840-f3dsu36p	2	40	:	:	:
cord-329840-f3dsu36p	3	1	bioRxiv	biorxiv	IN
cord-329840-f3dsu36p	3	2	DOI	DOI	NNP
cord-329840-f3dsu36p	3	3	:	:	:
cord-329840-f3dsu36p	4	1	10.1101/2020.05.07.083147	10.1101/2020.05.07.083147	CD
cord-329840-f3dsu36p	4	2	sha	sha	NNP
cord-329840-f3dsu36p	4	3	:	:	:
cord-329840-f3dsu36p	4	4	69fdc051472b7160bc31f79f8aa04a6489ee8dfc	69fdc051472b7160bc31f79f8aa04a6489ee8dfc	CD
cord-329840-f3dsu36p	4	5	doc_id	doc_id	CD
cord-329840-f3dsu36p	4	6	:	:	:
cord-329840-f3dsu36p	4	7	329840	329840	CD
cord-329840-f3dsu36p	4	8	cord_uid	cord_uid	NNS
cord-329840-f3dsu36p	4	9	:	:	:
cord-329840-f3dsu36p	4	10	f3dsu36p	f3dsu36p	PDT
cord-329840-f3dsu36p	4	11	The	the	DT
cord-329840-f3dsu36p	4	12	novel	novel	JJ
cord-329840-f3dsu36p	4	13	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	4	14	,	,	,
cord-329840-f3dsu36p	4	15	severe	severe	JJ
cord-329840-f3dsu36p	4	16	acute	acute	JJ
cord-329840-f3dsu36p	4	17	respiratory	respiratory	JJ
cord-329840-f3dsu36p	4	18	syndrome	syndrome	NN
cord-329840-f3dsu36p	4	19	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	4	20	2	2	CD
cord-329840-f3dsu36p	4	21	(	(	-LRB-
cord-329840-f3dsu36p	4	22	SARS	SARS	NNP
cord-329840-f3dsu36p	4	23	-	-	HYPH
cord-329840-f3dsu36p	4	24	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	4	25	)	)	-RRB-
cord-329840-f3dsu36p	4	26	,	,	,
cord-329840-f3dsu36p	4	27	has	have	VBZ
cord-329840-f3dsu36p	4	28	led	lead	VBN
cord-329840-f3dsu36p	4	29	to	to	IN
cord-329840-f3dsu36p	4	30	an	an	DT
cord-329840-f3dsu36p	4	31	ongoing	ongoing	JJ
cord-329840-f3dsu36p	4	32	pandemic	pandemic	NN
cord-329840-f3dsu36p	4	33	of	of	IN
cord-329840-f3dsu36p	4	34	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	4	35	disease	disease	NN
cord-329840-f3dsu36p	4	36	(	(	-LRB-
cord-329840-f3dsu36p	4	37	COVID-19	COVID-19	NNP
cord-329840-f3dsu36p	4	38	)	)	-RRB-
cord-329840-f3dsu36p	4	39	,	,	,
cord-329840-f3dsu36p	4	40	which	which	WDT
cord-329840-f3dsu36p	4	41	started	start	VBD
cord-329840-f3dsu36p	4	42	in	in	IN
cord-329840-f3dsu36p	4	43	2019	2019	CD
cord-329840-f3dsu36p	4	44	.	.	.
cord-329840-f3dsu36p	5	1	This	this	DT
cord-329840-f3dsu36p	5	2	is	be	VBZ
cord-329840-f3dsu36p	5	3	a	a	DT
cord-329840-f3dsu36p	5	4	member	member	NN
cord-329840-f3dsu36p	5	5	of	of	IN
cord-329840-f3dsu36p	5	6	Coronaviridae	Coronaviridae	NNP
cord-329840-f3dsu36p	5	7	family	family	NN
cord-329840-f3dsu36p	5	8	in	in	IN
cord-329840-f3dsu36p	5	9	the	the	DT
cord-329840-f3dsu36p	5	10	genus	genus	NN
cord-329840-f3dsu36p	5	11	Betacoronavirus	Betacoronavirus	NNP
cord-329840-f3dsu36p	5	12	,	,	,
cord-329840-f3dsu36p	5	13	which	which	WDT
cord-329840-f3dsu36p	5	14	also	also	RB
cord-329840-f3dsu36p	5	15	includes	include	VBZ
cord-329840-f3dsu36p	5	16	SARS	SARS	NNP
cord-329840-f3dsu36p	5	17	-	-	HYPH
cord-329840-f3dsu36p	5	18	CoV	CoV	NNP
cord-329840-f3dsu36p	5	19	and	and	CC
cord-329840-f3dsu36p	5	20	Middle	Middle	NNP
cord-329840-f3dsu36p	5	21	East	East	NNP
cord-329840-f3dsu36p	5	22	respiratory	respiratory	JJ
cord-329840-f3dsu36p	5	23	syndrome	syndrome	NN
cord-329840-f3dsu36p	5	24	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	5	25	(	(	-LRB-
cord-329840-f3dsu36p	5	26	MERS	MERS	NNP
cord-329840-f3dsu36p	5	27	-	-	HYPH
cord-329840-f3dsu36p	5	28	CoV	CoV	NNP
cord-329840-f3dsu36p	5	29	)	)	-RRB-
cord-329840-f3dsu36p	5	30	.	.	.
cord-329840-f3dsu36p	6	1	The	the	DT
cord-329840-f3dsu36p	6	2	angiotensin	angiotensin	NN
cord-329840-f3dsu36p	6	3	-	-	HYPH
cord-329840-f3dsu36p	6	4	converting	convert	VBG
cord-329840-f3dsu36p	6	5	enzyme	enzyme	NN
cord-329840-f3dsu36p	6	6	2	2	CD
cord-329840-f3dsu36p	6	7	(	(	-LRB-
cord-329840-f3dsu36p	6	8	ACE2	ACE2	NNP
cord-329840-f3dsu36p	6	9	)	)	-RRB-
cord-329840-f3dsu36p	6	10	is	be	VBZ
cord-329840-f3dsu36p	6	11	the	the	DT
cord-329840-f3dsu36p	6	12	functional	functional	JJ
cord-329840-f3dsu36p	6	13	receptor	receptor	NN
cord-329840-f3dsu36p	6	14	for	for	IN
cord-329840-f3dsu36p	6	15	SARS	SARS	NNP
cord-329840-f3dsu36p	6	16	-	-	HYPH
cord-329840-f3dsu36p	6	17	CoV	CoV	NNP
cord-329840-f3dsu36p	6	18	and	and	CC
cord-329840-f3dsu36p	6	19	SARS	SARS	NNP
cord-329840-f3dsu36p	6	20	-	-	HYPH
cord-329840-f3dsu36p	6	21	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	6	22	to	to	TO
cord-329840-f3dsu36p	6	23	enter	enter	VB
cord-329840-f3dsu36p	6	24	the	the	DT
cord-329840-f3dsu36p	6	25	host	host	NN
cord-329840-f3dsu36p	6	26	cells	cell	NNS
cord-329840-f3dsu36p	6	27	.	.	.
cord-329840-f3dsu36p	7	1	In	in	IN
cord-329840-f3dsu36p	7	2	particular	particular	JJ
cord-329840-f3dsu36p	7	3	,	,	,
cord-329840-f3dsu36p	7	4	the	the	DT
cord-329840-f3dsu36p	7	5	interaction	interaction	NN
cord-329840-f3dsu36p	7	6	of	of	IN
cord-329840-f3dsu36p	7	7	viral	viral	JJ
cord-329840-f3dsu36p	7	8	spike	spike	NN
cord-329840-f3dsu36p	7	9	proteins	protein	NNS
cord-329840-f3dsu36p	7	10	with	with	IN
cord-329840-f3dsu36p	7	11	ACE2	ACE2	NNP
cord-329840-f3dsu36p	7	12	is	be	VBZ
cord-329840-f3dsu36p	7	13	a	a	DT
cord-329840-f3dsu36p	7	14	critical	critical	JJ
cord-329840-f3dsu36p	7	15	step	step	NN
cord-329840-f3dsu36p	7	16	in	in	IN
cord-329840-f3dsu36p	7	17	the	the	DT
cord-329840-f3dsu36p	7	18	viral	viral	JJ
cord-329840-f3dsu36p	7	19	replication	replication	NN
cord-329840-f3dsu36p	7	20	cycle	cycle	NN
cord-329840-f3dsu36p	7	21	.	.	.
cord-329840-f3dsu36p	8	1	The	the	DT
cord-329840-f3dsu36p	8	2	receptor	receptor	NN
cord-329840-f3dsu36p	8	3	binding	bind	VBG
cord-329840-f3dsu36p	8	4	domain	domain	NN
cord-329840-f3dsu36p	8	5	of	of	IN
cord-329840-f3dsu36p	8	6	the	the	DT
cord-329840-f3dsu36p	8	7	viral	viral	JJ
cord-329840-f3dsu36p	8	8	spike	spike	NN
cord-329840-f3dsu36p	8	9	proteins	protein	NNS
cord-329840-f3dsu36p	8	10	and	and	CC
cord-329840-f3dsu36p	8	11	ACE2	ACE2	NNP
cord-329840-f3dsu36p	8	12	have	have	VBP
cord-329840-f3dsu36p	8	13	several	several	JJ
cord-329840-f3dsu36p	8	14	cysteine	cysteine	NN
cord-329840-f3dsu36p	8	15	residues	residue	NNS
cord-329840-f3dsu36p	8	16	.	.	.
cord-329840-f3dsu36p	9	1	In	in	IN
cord-329840-f3dsu36p	9	2	this	this	DT
cord-329840-f3dsu36p	9	3	study	study	NN
cord-329840-f3dsu36p	9	4	,	,	,
cord-329840-f3dsu36p	9	5	the	the	DT
cord-329840-f3dsu36p	9	6	role	role	NN
cord-329840-f3dsu36p	9	7	of	of	IN
cord-329840-f3dsu36p	9	8	thiol	thiol	NN
cord-329840-f3dsu36p	9	9	-	-	HYPH
cord-329840-f3dsu36p	9	10	disulfide	disulfide	NN
cord-329840-f3dsu36p	9	11	balance	balance	NN
cord-329840-f3dsu36p	9	12	on	on	IN
cord-329840-f3dsu36p	9	13	the	the	DT
cord-329840-f3dsu36p	9	14	interactions	interaction	NNS
cord-329840-f3dsu36p	9	15	between	between	IN
cord-329840-f3dsu36p	9	16	SARS	SARS	NNP
cord-329840-f3dsu36p	9	17	-	-	HYPH
cord-329840-f3dsu36p	9	18	CoV	CoV	NNP
cord-329840-f3dsu36p	9	19	/	/	,
cord-329840-f3dsu36p	9	20	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	9	21	spike	spike	NN
cord-329840-f3dsu36p	9	22	proteins	protein	NNS
cord-329840-f3dsu36p	9	23	and	and	CC
cord-329840-f3dsu36p	9	24	ACE2	ACE2	NNP
cord-329840-f3dsu36p	9	25	was	be	VBD
cord-329840-f3dsu36p	9	26	investigated	investigate	VBN
cord-329840-f3dsu36p	9	27	using	use	VBG
cord-329840-f3dsu36p	9	28	molecular	molecular	JJ
cord-329840-f3dsu36p	9	29	dynamic	dynamic	JJ
cord-329840-f3dsu36p	9	30	simulations	simulation	NNS
cord-329840-f3dsu36p	9	31	.	.	.
cord-329840-f3dsu36p	10	1	The	the	DT
cord-329840-f3dsu36p	10	2	study	study	NN
cord-329840-f3dsu36p	10	3	revealed	reveal	VBD
cord-329840-f3dsu36p	10	4	that	that	IN
cord-329840-f3dsu36p	10	5	the	the	DT
cord-329840-f3dsu36p	10	6	binding	bind	VBG
cord-329840-f3dsu36p	10	7	affinity	affinity	NN
cord-329840-f3dsu36p	10	8	was	be	VBD
cord-329840-f3dsu36p	10	9	significantly	significantly	RB
cord-329840-f3dsu36p	10	10	impaired	impair	VBN
cord-329840-f3dsu36p	10	11	when	when	WRB
cord-329840-f3dsu36p	10	12	all	all	PDT
cord-329840-f3dsu36p	10	13	the	the	DT
cord-329840-f3dsu36p	10	14	disulfide	disulfide	JJ
cord-329840-f3dsu36p	10	15	bonds	bond	NNS
cord-329840-f3dsu36p	10	16	of	of	IN
cord-329840-f3dsu36p	10	17	both	both	CC
cord-329840-f3dsu36p	10	18	ACE2	ACE2	NNP
cord-329840-f3dsu36p	10	19	and	and	CC
cord-329840-f3dsu36p	10	20	SARS	SARS	NNP
cord-329840-f3dsu36p	10	21	-	-	HYPH
cord-329840-f3dsu36p	10	22	CoV	CoV	NNP
cord-329840-f3dsu36p	10	23	/	/	,
cord-329840-f3dsu36p	10	24	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	10	25	spike	spike	NN
cord-329840-f3dsu36p	10	26	proteins	protein	NNS
cord-329840-f3dsu36p	10	27	were	be	VBD
cord-329840-f3dsu36p	10	28	reduced	reduce	VBN
cord-329840-f3dsu36p	10	29	to	to	IN
cord-329840-f3dsu36p	10	30	thiol	thiol	NN
cord-329840-f3dsu36p	10	31	groups	group	NNS
cord-329840-f3dsu36p	10	32	.	.	.
cord-329840-f3dsu36p	11	1	The	the	DT
cord-329840-f3dsu36p	11	2	impact	impact	NN
cord-329840-f3dsu36p	11	3	on	on	IN
cord-329840-f3dsu36p	11	4	the	the	DT
cord-329840-f3dsu36p	11	5	binding	bind	VBG
cord-329840-f3dsu36p	11	6	affinity	affinity	NN
cord-329840-f3dsu36p	11	7	was	be	VBD
cord-329840-f3dsu36p	11	8	less	less	RBR
cord-329840-f3dsu36p	11	9	severe	severe	JJ
cord-329840-f3dsu36p	11	10	when	when	WRB
cord-329840-f3dsu36p	11	11	the	the	DT
cord-329840-f3dsu36p	11	12	disulfide	disulfide	JJ
cord-329840-f3dsu36p	11	13	bridges	bridge	NNS
cord-329840-f3dsu36p	11	14	of	of	IN
cord-329840-f3dsu36p	11	15	only	only	RB
cord-329840-f3dsu36p	11	16	one	one	CD
cord-329840-f3dsu36p	11	17	of	of	IN
cord-329840-f3dsu36p	11	18	the	the	DT
cord-329840-f3dsu36p	11	19	binding	bind	VBG
cord-329840-f3dsu36p	11	20	partners	partner	NNS
cord-329840-f3dsu36p	11	21	were	be	VBD
cord-329840-f3dsu36p	11	22	reduced	reduce	VBN
cord-329840-f3dsu36p	11	23	to	to	IN
cord-329840-f3dsu36p	11	24	thiols	thiol	NNS
cord-329840-f3dsu36p	11	25	.	.	.
cord-329840-f3dsu36p	12	1	This	this	DT
cord-329840-f3dsu36p	12	2	computational	computational	JJ
cord-329840-f3dsu36p	12	3	finding	finding	NN
cord-329840-f3dsu36p	12	4	provides	provide	VBZ
cord-329840-f3dsu36p	12	5	a	a	DT
cord-329840-f3dsu36p	12	6	molecular	molecular	JJ
cord-329840-f3dsu36p	12	7	basis	basis	NN
cord-329840-f3dsu36p	12	8	for	for	IN
cord-329840-f3dsu36p	12	9	the	the	DT
cord-329840-f3dsu36p	12	10	severity	severity	NN
cord-329840-f3dsu36p	12	11	of	of	IN
cord-329840-f3dsu36p	12	12	COVID-19	covid-19	JJ
cord-329840-f3dsu36p	12	13	infection	infection	NN
cord-329840-f3dsu36p	12	14	due	due	IN
cord-329840-f3dsu36p	12	15	to	to	IN
cord-329840-f3dsu36p	12	16	the	the	DT
cord-329840-f3dsu36p	12	17	oxidative	oxidative	JJ
cord-329840-f3dsu36p	12	18	stress	stress	NN
cord-329840-f3dsu36p	12	19	.	.	.
cord-329840-f3dsu36p	13	1	The	the	DT
cord-329840-f3dsu36p	13	2	novel	novel	JJ
cord-329840-f3dsu36p	13	3	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	13	4	known	know	VBN
cord-329840-f3dsu36p	13	5	as	as	IN
cord-329840-f3dsu36p	13	6	severe	severe	JJ
cord-329840-f3dsu36p	13	7	acute	acute	JJ
cord-329840-f3dsu36p	13	8	respiratory	respiratory	JJ
cord-329840-f3dsu36p	13	9	syndrome	syndrome	NN
cord-329840-f3dsu36p	13	10	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	13	11	2	2	CD
cord-329840-f3dsu36p	14	1	(	(	-LRB-
cord-329840-f3dsu36p	14	2	SARS	SARS	NNP
cord-329840-f3dsu36p	14	3	-	-	HYPH
cord-329840-f3dsu36p	14	4	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	14	5	)	)	-RRB-
cord-329840-f3dsu36p	14	6	or	or	CC
cord-329840-f3dsu36p	14	7	simply	simply	RB
cord-329840-f3dsu36p	14	8	COVID-19	covid-19	VB
cord-329840-f3dsu36p	14	9	is	be	VBZ
cord-329840-f3dsu36p	14	10	the	the	DT
cord-329840-f3dsu36p	14	11	seventh	seventh	JJ
cord-329840-f3dsu36p	14	12	member	member	NN
cord-329840-f3dsu36p	14	13	of	of	IN
cord-329840-f3dsu36p	14	14	the	the	DT
cord-329840-f3dsu36p	14	15	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	14	16	family	family	NN
cord-329840-f3dsu36p	14	17	.	.	.
cord-329840-f3dsu36p	15	1	1	1	LS
cord-329840-f3dsu36p	16	1	The	the	DT
cord-329840-f3dsu36p	16	2	other	other	JJ
cord-329840-f3dsu36p	16	3	two	two	CD
cord-329840-f3dsu36p	16	4	viruses	virus	NNS
cord-329840-f3dsu36p	16	5	in	in	IN
cord-329840-f3dsu36p	16	6	this	this	DT
cord-329840-f3dsu36p	16	7	family	family	NN
cord-329840-f3dsu36p	16	8	that	that	WDT
cord-329840-f3dsu36p	16	9	infect	infect	VBP
cord-329840-f3dsu36p	16	10	humans	human	NNS
cord-329840-f3dsu36p	16	11	are	be	VBP
cord-329840-f3dsu36p	16	12	severe	severe	JJ
cord-329840-f3dsu36p	16	13	acute	acute	JJ
cord-329840-f3dsu36p	16	14	respiratory	respiratory	JJ
cord-329840-f3dsu36p	16	15	syndrome	syndrome	NN
cord-329840-f3dsu36p	16	16	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	16	17	(	(	-LRB-
cord-329840-f3dsu36p	16	18	SARS	SARS	NNP
cord-329840-f3dsu36p	16	19	-	-	HYPH
cord-329840-f3dsu36p	16	20	CoV	CoV	NNP
cord-329840-f3dsu36p	16	21	)	)	-RRB-
cord-329840-f3dsu36p	16	22	and	and	CC
cord-329840-f3dsu36p	16	23	Middle	Middle	NNP
cord-329840-f3dsu36p	16	24	East	East	NNP
cord-329840-f3dsu36p	16	25	respiratory	respiratory	JJ
cord-329840-f3dsu36p	16	26	syndrome	syndrome	NN
cord-329840-f3dsu36p	16	27	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	16	28	(	(	-LRB-
cord-329840-f3dsu36p	16	29	MERS	MERS	NNP
cord-329840-f3dsu36p	16	30	-	-	HYPH
cord-329840-f3dsu36p	16	31	CoV	CoV	NNP
cord-329840-f3dsu36p	16	32	)	)	-RRB-
cord-329840-f3dsu36p	16	33	.	.	.
cord-329840-f3dsu36p	17	1	These	these	DT
cord-329840-f3dsu36p	17	2	are	be	VBP
cord-329840-f3dsu36p	17	3	positive	positive	JJ
cord-329840-f3dsu36p	17	4	-	-	HYPH
cord-329840-f3dsu36p	17	5	sense	sense	NN
cord-329840-f3dsu36p	17	6	,	,	,
cord-329840-f3dsu36p	17	7	single	single	JJ
cord-329840-f3dsu36p	17	8	-	-	HYPH
cord-329840-f3dsu36p	17	9	strand	strand	NN
cord-329840-f3dsu36p	17	10	enveloped	envelop	VBN
cord-329840-f3dsu36p	17	11	RNA	RNA	NNP
cord-329840-f3dsu36p	17	12	viruses	virus	NNS
cord-329840-f3dsu36p	17	13	.	.	.
cord-329840-f3dsu36p	18	1	The	the	DT
cord-329840-f3dsu36p	18	2	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	18	3	particles	particle	NNS
cord-329840-f3dsu36p	18	4	contain	contain	VBP
cord-329840-f3dsu36p	18	5	four	four	CD
cord-329840-f3dsu36p	18	6	main	main	JJ
cord-329840-f3dsu36p	18	7	structural	structural	JJ
cord-329840-f3dsu36p	18	8	proteins	protein	NNS
cord-329840-f3dsu36p	18	9	:	:	:
cord-329840-f3dsu36p	18	10	the	the	DT
cord-329840-f3dsu36p	18	11	spike	spike	NN
cord-329840-f3dsu36p	18	12	,	,	,
cord-329840-f3dsu36p	18	13	membrane	membrane	NN
cord-329840-f3dsu36p	18	14	,	,	,
cord-329840-f3dsu36p	18	15	envelope	envelope	NN
cord-329840-f3dsu36p	18	16	,	,	,
cord-329840-f3dsu36p	18	17	and	and	CC
cord-329840-f3dsu36p	18	18	nucleocapsid	nucleocapsid	NN
cord-329840-f3dsu36p	18	19	.	.	.
cord-329840-f3dsu36p	19	1	[	[	-LRB-
cord-329840-f3dsu36p	19	2	1	1	CD
cord-329840-f3dsu36p	19	3	]	]	-RRB-
cord-329840-f3dsu36p	19	4	[	[	-LRB-
cord-329840-f3dsu36p	19	5	2	2	CD
cord-329840-f3dsu36p	19	6	]	]	-RRB-
cord-329840-f3dsu36p	20	1	The	the	DT
cord-329840-f3dsu36p	20	2	spike	spike	NN
cord-329840-f3dsu36p	20	3	protein	protein	NN
cord-329840-f3dsu36p	20	4	protrudes	protrude	VBZ
cord-329840-f3dsu36p	20	5	from	from	IN
cord-329840-f3dsu36p	20	6	the	the	DT
cord-329840-f3dsu36p	20	7	envelope	envelope	NN
cord-329840-f3dsu36p	20	8	of	of	IN
cord-329840-f3dsu36p	20	9	the	the	DT
cord-329840-f3dsu36p	20	10	virion	virion	NN
cord-329840-f3dsu36p	20	11	and	and	CC
cord-329840-f3dsu36p	20	12	consists	consist	VBZ
cord-329840-f3dsu36p	20	13	of	of	IN
cord-329840-f3dsu36p	20	14	two	two	CD
cord-329840-f3dsu36p	20	15	subunits	subunit	NNS
cord-329840-f3dsu36p	20	16	;	;	:
cord-329840-f3dsu36p	20	17	a	a	DT
cord-329840-f3dsu36p	20	18	receptor	receptor	NN
cord-329840-f3dsu36p	20	19	-	-	HYPH
cord-329840-f3dsu36p	20	20	binding	bind	VBG
cord-329840-f3dsu36p	20	21	domain	domain	NN
cord-329840-f3dsu36p	20	22	(	(	-LRB-
cord-329840-f3dsu36p	20	23	RBD	RBD	NNP
cord-329840-f3dsu36p	20	24	)	)	-RRB-
cord-329840-f3dsu36p	20	25	that	that	WDT
cord-329840-f3dsu36p	20	26	interacts	interact	VBZ
cord-329840-f3dsu36p	20	27	with	with	IN
cord-329840-f3dsu36p	20	28	the	the	DT
cord-329840-f3dsu36p	20	29	receptor	receptor	NN
cord-329840-f3dsu36p	20	30	proteins	protein	NNS
cord-329840-f3dsu36p	20	31	of	of	IN
cord-329840-f3dsu36p	20	32	host	host	NN
cord-329840-f3dsu36p	20	33	cells	cell	NNS
cord-329840-f3dsu36p	20	34	and	and	CC
cord-329840-f3dsu36p	20	35	a	a	DT
cord-329840-f3dsu36p	20	36	second	second	JJ
cord-329840-f3dsu36p	20	37	subunit	subunit	NN
cord-329840-f3dsu36p	20	38	that	that	WDT
cord-329840-f3dsu36p	20	39	facilitates	facilitate	VBZ
cord-329840-f3dsu36p	20	40	fusion	fusion	NN
cord-329840-f3dsu36p	20	41	of	of	IN
cord-329840-f3dsu36p	20	42	the	the	DT
cord-329840-f3dsu36p	20	43	viral	viral	JJ
cord-329840-f3dsu36p	20	44	membrane	membrane	NN
cord-329840-f3dsu36p	20	45	into	into	IN
cord-329840-f3dsu36p	20	46	the	the	DT
cord-329840-f3dsu36p	20	47	host	host	NN
cord-329840-f3dsu36p	20	48	cell	cell	NN
cord-329840-f3dsu36p	20	49	membrane	membrane	NN
cord-329840-f3dsu36p	20	50	.	.	.
cord-329840-f3dsu36p	21	1	Recent	recent	JJ
cord-329840-f3dsu36p	21	2	studies	study	NNS
cord-329840-f3dsu36p	21	3	showed	show	VBD
cord-329840-f3dsu36p	21	4	that	that	IN
cord-329840-f3dsu36p	21	5	RBD	RBD	NNP
cord-329840-f3dsu36p	21	6	of	of	IN
cord-329840-f3dsu36p	21	7	spike	spike	NN
cord-329840-f3dsu36p	21	8	proteins	protein	NNS
cord-329840-f3dsu36p	21	9	of	of	IN
cord-329840-f3dsu36p	21	10	SARS	SARS	NNP
cord-329840-f3dsu36p	21	11	-	-	HYPH
cord-329840-f3dsu36p	21	12	CoV	CoV	NNP
cord-329840-f3dsu36p	21	13	and	and	CC
cord-329840-f3dsu36p	21	14	SARS	SARS	NNP
cord-329840-f3dsu36p	21	15	-	-	:
cord-329840-f3dsu36p	21	16	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	21	17	interact	interact	VBP
cord-329840-f3dsu36p	21	18	with	with	IN
cord-329840-f3dsu36p	21	19	angiotensin	angiotensin	NN
cord-329840-f3dsu36p	21	20	-	-	HYPH
cord-329840-f3dsu36p	21	21	converting	convert	VBG
cord-329840-f3dsu36p	21	22	enzyme	enzyme	NN
cord-329840-f3dsu36p	21	23	2	2	CD
cord-329840-f3dsu36p	21	24	(	(	-LRB-
cord-329840-f3dsu36p	21	25	ACE2	ACE2	NNP
cord-329840-f3dsu36p	21	26	)	)	-RRB-
cord-329840-f3dsu36p	21	27	.	.	.
cord-329840-f3dsu36p	22	1	ACE2	ACE2	NNP
cord-329840-f3dsu36p	22	2	belongs	belong	VBZ
cord-329840-f3dsu36p	22	3	to	to	IN
cord-329840-f3dsu36p	22	4	the	the	DT
cord-329840-f3dsu36p	22	5	membrane	membrane	NN
cord-329840-f3dsu36p	22	6	-	-	HYPH
cord-329840-f3dsu36p	22	7	bound	bind	VBN
cord-329840-f3dsu36p	22	8	carboxydipeptidase	carboxydipeptidase	NN
cord-329840-f3dsu36p	22	9	family	family	NN
cord-329840-f3dsu36p	22	10	.	.	.
cord-329840-f3dsu36p	23	1	It	-PRON-	PRP
cord-329840-f3dsu36p	23	2	is	be	VBZ
cord-329840-f3dsu36p	23	3	attached	attach	VBN
cord-329840-f3dsu36p	23	4	to	to	IN
cord-329840-f3dsu36p	23	5	the	the	DT
cord-329840-f3dsu36p	23	6	outer	outer	JJ
cord-329840-f3dsu36p	23	7	surfaces	surface	NNS
cord-329840-f3dsu36p	23	8	of	of	IN
cord-329840-f3dsu36p	23	9	cells	cell	NNS
cord-329840-f3dsu36p	23	10	and	and	CC
cord-329840-f3dsu36p	23	11	is	be	VBZ
cord-329840-f3dsu36p	23	12	widely	widely	RB
cord-329840-f3dsu36p	23	13	distributed	distribute	VBN
cord-329840-f3dsu36p	23	14	in	in	IN
cord-329840-f3dsu36p	23	15	the	the	DT
cord-329840-f3dsu36p	23	16	human	human	JJ
cord-329840-f3dsu36p	23	17	body	body	NN
cord-329840-f3dsu36p	23	18	.	.	.
cord-329840-f3dsu36p	24	1	In	in	IN
cord-329840-f3dsu36p	24	2	particular	particular	JJ
cord-329840-f3dsu36p	24	3	,	,	,
cord-329840-f3dsu36p	24	4	higher	high	JJR
cord-329840-f3dsu36p	24	5	expression	expression	NN
cord-329840-f3dsu36p	24	6	of	of	IN
cord-329840-f3dsu36p	24	7	ACE2	ACE2	NNP
cord-329840-f3dsu36p	24	8	is	be	VBZ
cord-329840-f3dsu36p	24	9	observed	observe	VBN
cord-329840-f3dsu36p	24	10	in	in	IN
cord-329840-f3dsu36p	24	11	organs	organ	NNS
cord-329840-f3dsu36p	24	12	such	such	JJ
cord-329840-f3dsu36p	24	13	as	as	IN
cord-329840-f3dsu36p	24	14	small	small	JJ
cord-329840-f3dsu36p	24	15	intestine	intestine	NN
cord-329840-f3dsu36p	24	16	,	,	,
cord-329840-f3dsu36p	24	17	colon	colon	NN
cord-329840-f3dsu36p	24	18	,	,	,
cord-329840-f3dsu36p	24	19	kidney	kidney	NN
cord-329840-f3dsu36p	24	20	,	,	,
cord-329840-f3dsu36p	24	21	and	and	CC
cord-329840-f3dsu36p	24	22	heart	heart	NN
cord-329840-f3dsu36p	24	23	,	,	,
cord-329840-f3dsu36p	24	24	while	while	IN
cord-329840-f3dsu36p	24	25	ACE2	ACE2	NNP
cord-329840-f3dsu36p	24	26	expression	expression	NN
cord-329840-f3dsu36p	24	27	is	be	VBZ
cord-329840-f3dsu36p	24	28	comparatively	comparatively	RB
cord-329840-f3dsu36p	24	29	lower	low	JJR
cord-329840-f3dsu36p	24	30	in	in	IN
cord-329840-f3dsu36p	24	31	liver	liver	NN
cord-329840-f3dsu36p	24	32	and	and	CC
cord-329840-f3dsu36p	24	33	lungs	lung	NNS
cord-329840-f3dsu36p	24	34	.	.	.
cord-329840-f3dsu36p	25	1	[	[	-LRB-
cord-329840-f3dsu36p	25	2	3	3	CD
cord-329840-f3dsu36p	25	3	]	]	-RRB-
cord-329840-f3dsu36p	25	4	[	[	-LRB-
cord-329840-f3dsu36p	25	5	4	4	CD
cord-329840-f3dsu36p	25	6	]	]	-RRB-
cord-329840-f3dsu36p	26	1	The	the	DT
cord-329840-f3dsu36p	26	2	role	role	NN
cord-329840-f3dsu36p	26	3	of	of	IN
cord-329840-f3dsu36p	26	4	oxidative	oxidative	JJ
cord-329840-f3dsu36p	26	5	stress	stress	NN
cord-329840-f3dsu36p	26	6	on	on	IN
cord-329840-f3dsu36p	26	7	the	the	DT
cord-329840-f3dsu36p	26	8	binding	binding	NN
cord-329840-f3dsu36p	26	9	of	of	IN
cord-329840-f3dsu36p	26	10	viral	viral	JJ
cord-329840-f3dsu36p	26	11	proteins	protein	NNS
cord-329840-f3dsu36p	26	12	on	on	IN
cord-329840-f3dsu36p	26	13	the	the	DT
cord-329840-f3dsu36p	26	14	host	host	NN
cord-329840-f3dsu36p	26	15	cell	cell	NN
cord-329840-f3dsu36p	26	16	surface	surface	NN
cord-329840-f3dsu36p	26	17	receptors	receptor	NNS
cord-329840-f3dsu36p	26	18	is	be	VBZ
cord-329840-f3dsu36p	26	19	a	a	DT
cord-329840-f3dsu36p	26	20	relatively	relatively	RB
cord-329840-f3dsu36p	26	21	underexplored	underexplored	JJ
cord-329840-f3dsu36p	26	22	area	area	NN
cord-329840-f3dsu36p	26	23	of	of	IN
cord-329840-f3dsu36p	26	24	biomedical	biomedical	JJ
cord-329840-f3dsu36p	26	25	research	research	NN
cord-329840-f3dsu36p	26	26	.	.	.
cord-329840-f3dsu36p	27	1	[	[	-LRB-
cord-329840-f3dsu36p	27	2	5	5	CD
cord-329840-f3dsu36p	27	3	]	]	-RRB-
cord-329840-f3dsu36p	27	4	[	[	-LRB-
cord-329840-f3dsu36p	27	5	6	6	CD
cord-329840-f3dsu36p	27	6	]	]	-RRB-
cord-329840-f3dsu36p	27	7	[	[	-LRB-
cord-329840-f3dsu36p	27	8	7	7	CD
cord-329840-f3dsu36p	27	9	]	]	-RRB-
cord-329840-f3dsu36p	28	1	[	[	-LRB-
cord-329840-f3dsu36p	28	2	8	8	CD
cord-329840-f3dsu36p	28	3	]	]	-RRB-
cord-329840-f3dsu36p	28	4	[	[	-LRB-
cord-329840-f3dsu36p	28	5	9	9	CD
cord-329840-f3dsu36p	28	6	]	]	-RRB-
cord-329840-f3dsu36p	28	7	[	[	-LRB-
cord-329840-f3dsu36p	28	8	10	10	CD
cord-329840-f3dsu36p	28	9	]	]	-RRB-
cord-329840-f3dsu36p	29	1	Previous	previous	JJ
cord-329840-f3dsu36p	29	2	studies	study	NNS
cord-329840-f3dsu36p	29	3	have	have	VBP
cord-329840-f3dsu36p	29	4	indicated	indicate	VBN
cord-329840-f3dsu36p	29	5	that	that	IN
cord-329840-f3dsu36p	29	6	the	the	DT
cord-329840-f3dsu36p	29	7	entry	entry	NN
cord-329840-f3dsu36p	29	8	of	of	IN
cord-329840-f3dsu36p	29	9	viral	viral	JJ
cord-329840-f3dsu36p	29	10	glycoprotein	glycoprotein	NN
cord-329840-f3dsu36p	29	11	is	be	VBZ
cord-329840-f3dsu36p	29	12	impacted	impact	VBN
cord-329840-f3dsu36p	29	13	by	by	IN
cord-329840-f3dsu36p	29	14	thiol	thiol	NN
cord-329840-f3dsu36p	29	15	-	-	HYPH
cord-329840-f3dsu36p	29	16	disulfide	disulfide	NN
cord-329840-f3dsu36p	29	17	balance	balance	NN
cord-329840-f3dsu36p	29	18	on	on	IN
cord-329840-f3dsu36p	29	19	the	the	DT
cord-329840-f3dsu36p	29	20	cell	cell	NN
cord-329840-f3dsu36p	29	21	surface	surface	NN
cord-329840-f3dsu36p	29	22	.	.	.
cord-329840-f3dsu36p	30	1	5	5	LS
cord-329840-f3dsu36p	30	2	,	,	,
cord-329840-f3dsu36p	30	3	[	[	-LRB-
cord-329840-f3dsu36p	30	4	7	7	CD
cord-329840-f3dsu36p	30	5	]	]	-RRB-
cord-329840-f3dsu36p	30	6	[	[	-LRB-
cord-329840-f3dsu36p	30	7	8	8	CD
cord-329840-f3dsu36p	30	8	]	]	-RRB-
cord-329840-f3dsu36p	30	9	[	[	-LRB-
cord-329840-f3dsu36p	30	10	9	9	CD
cord-329840-f3dsu36p	30	11	]	]	-RRB-
cord-329840-f3dsu36p	30	12	[	[	-LRB-
cord-329840-f3dsu36p	30	13	11	11	CD
cord-329840-f3dsu36p	30	14	]	]	-RRB-
cord-329840-f3dsu36p	30	15	[	[	-LRB-
cord-329840-f3dsu36p	30	16	12	12	CD
cord-329840-f3dsu36p	30	17	]	]	-RRB-
cord-329840-f3dsu36p	31	1	Any	any	DT
cord-329840-f3dsu36p	31	2	perturbations	perturbation	NNS
cord-329840-f3dsu36p	31	3	in	in	IN
cord-329840-f3dsu36p	31	4	the	the	DT
cord-329840-f3dsu36p	31	5	thiol	thiol	NN
cord-329840-f3dsu36p	31	6	-	-	HYPH
cord-329840-f3dsu36p	31	7	disulfide	disulfide	NN
cord-329840-f3dsu36p	31	8	equilibrium	equilibrium	NN
cord-329840-f3dsu36p	31	9	has	have	VBZ
cord-329840-f3dsu36p	31	10	also	also	RB
cord-329840-f3dsu36p	31	11	been	be	VBN
cord-329840-f3dsu36p	31	12	found	find	VBN
cord-329840-f3dsu36p	31	13	to	to	TO
cord-329840-f3dsu36p	31	14	deter	deter	VB
cord-329840-f3dsu36p	31	15	the	the	DT
cord-329840-f3dsu36p	31	16	entry	entry	NN
cord-329840-f3dsu36p	31	17	of	of	IN
cord-329840-f3dsu36p	31	18	viruses	virus	NNS
cord-329840-f3dsu36p	31	19	into	into	IN
cord-329840-f3dsu36p	31	20	their	-PRON-	PRP$
cord-329840-f3dsu36p	31	21	target	target	NN
cord-329840-f3dsu36p	31	22	cells	cell	NNS
cord-329840-f3dsu36p	31	23	.	.	.
cord-329840-f3dsu36p	32	1	5	5	LS
cord-329840-f3dsu36p	33	1	The	the	DT
cord-329840-f3dsu36p	33	2	first	first	JJ
cord-329840-f3dsu36p	33	3	step	step	NN
cord-329840-f3dsu36p	33	4	of	of	IN
cord-329840-f3dsu36p	33	5	the	the	DT
cord-329840-f3dsu36p	33	6	viral	viral	JJ
cord-329840-f3dsu36p	33	7	entry	entry	NN
cord-329840-f3dsu36p	33	8	involves	involve	VBZ
cord-329840-f3dsu36p	33	9	binding	binding	NN
cord-329840-f3dsu36p	33	10	of	of	IN
cord-329840-f3dsu36p	33	11	the	the	DT
cord-329840-f3dsu36p	33	12	viral	viral	JJ
cord-329840-f3dsu36p	33	13	envelop	envelop	NN
cord-329840-f3dsu36p	33	14	protein	protein	NN
cord-329840-f3dsu36p	33	15	onto	onto	IN
cord-329840-f3dsu36p	33	16	a	a	DT
cord-329840-f3dsu36p	33	17	cellular	cellular	JJ
cord-329840-f3dsu36p	33	18	receptor	receptor	NN
cord-329840-f3dsu36p	33	19	.	.	.
cord-329840-f3dsu36p	34	1	This	this	DT
cord-329840-f3dsu36p	34	2	is	be	VBZ
cord-329840-f3dsu36p	34	3	followed	follow	VBN
cord-329840-f3dsu36p	34	4	by	by	IN
cord-329840-f3dsu36p	34	5	endocytosis	endocytosis	NN
cord-329840-f3dsu36p	34	6	,	,	,
cord-329840-f3dsu36p	34	7	after	after	IN
cord-329840-f3dsu36p	34	8	which	which	WDT
cord-329840-f3dsu36p	34	9	conformational	conformational	JJ
cord-329840-f3dsu36p	34	10	changes	change	NNS
cord-329840-f3dsu36p	34	11	of	of	IN
cord-329840-f3dsu36p	34	12	the	the	DT
cord-329840-f3dsu36p	34	13	viral	viral	JJ
cord-329840-f3dsu36p	34	14	protein	protein	NN
cord-329840-f3dsu36p	34	15	helps	help	VBZ
cord-329840-f3dsu36p	34	16	the	the	DT
cord-329840-f3dsu36p	34	17	induction	induction	NN
cord-329840-f3dsu36p	34	18	of	of	IN
cord-329840-f3dsu36p	34	19	the	the	DT
cord-329840-f3dsu36p	34	20	viral	viral	JJ
cord-329840-f3dsu36p	34	21	protein	protein	NN
cord-329840-f3dsu36p	34	22	into	into	IN
cord-329840-f3dsu36p	34	23	the	the	DT
cord-329840-f3dsu36p	34	24	endosomal	endosomal	NNP
cord-329840-f3dsu36p	34	25	membrane	membrane	NN
cord-329840-f3dsu36p	34	26	,	,	,
cord-329840-f3dsu36p	34	27	finally	finally	RB
cord-329840-f3dsu36p	34	28	releasing	release	VBG
cord-329840-f3dsu36p	34	29	the	the	DT
cord-329840-f3dsu36p	34	30	viral	viral	JJ
cord-329840-f3dsu36p	34	31	content	content	NN
cord-329840-f3dsu36p	34	32	into	into	IN
cord-329840-f3dsu36p	34	33	the	the	DT
cord-329840-f3dsu36p	34	34	cell	cell	NN
cord-329840-f3dsu36p	34	35	.	.	.
cord-329840-f3dsu36p	35	1	These	these	DT
cord-329840-f3dsu36p	35	2	conformational	conformational	JJ
cord-329840-f3dsu36p	35	3	changes	change	NNS
cord-329840-f3dsu36p	35	4	are	be	VBP
cord-329840-f3dsu36p	35	5	mediated	mediate	VBN
cord-329840-f3dsu36p	35	6	by	by	IN
cord-329840-f3dsu36p	35	7	pH	pH	NNP
cord-329840-f3dsu36p	35	8	changes	change	NNS
cord-329840-f3dsu36p	35	9	as	as	RB
cord-329840-f3dsu36p	35	10	well	well	RB
cord-329840-f3dsu36p	35	11	as	as	IN
cord-329840-f3dsu36p	35	12	the	the	DT
cord-329840-f3dsu36p	35	13	conversion	conversion	NN
cord-329840-f3dsu36p	35	14	of	of	IN
cord-329840-f3dsu36p	35	15	disulfide	disulfide	NN
cord-329840-f3dsu36p	35	16	to	to	IN
cord-329840-f3dsu36p	35	17	thiol	thiol	NN
cord-329840-f3dsu36p	35	18	group	group	NN
cord-329840-f3dsu36p	35	19	of	of	IN
cord-329840-f3dsu36p	35	20	the	the	DT
cord-329840-f3dsu36p	35	21	viral	viral	JJ
cord-329840-f3dsu36p	35	22	spike	spike	NN
cord-329840-f3dsu36p	35	23	protein	protein	NN
cord-329840-f3dsu36p	35	24	.	.	.
cord-329840-f3dsu36p	36	1	7	7	CD
cord-329840-f3dsu36p	37	1	Several	several	JJ
cord-329840-f3dsu36p	37	2	cell	cell	NN
cord-329840-f3dsu36p	37	3	surface	surface	NN
cord-329840-f3dsu36p	37	4	oxidoreductases	oxidoreductase	NNS
cord-329840-f3dsu36p	37	5	9	9	CD
cord-329840-f3dsu36p	37	6	regulate	regulate	VBP
cord-329840-f3dsu36p	37	7	the	the	DT
cord-329840-f3dsu36p	37	8	thiol	thiol	NN
cord-329840-f3dsu36p	37	9	-	-	HYPH
cord-329840-f3dsu36p	37	10	disulfide	disulfide	NN
cord-329840-f3dsu36p	37	11	exchange	exchange	NN
cord-329840-f3dsu36p	37	12	,	,	,
cord-329840-f3dsu36p	37	13	responsible	responsible	JJ
cord-329840-f3dsu36p	37	14	for	for	IN
cord-329840-f3dsu36p	37	15	conformational	conformational	JJ
cord-329840-f3dsu36p	37	16	changes	change	NNS
cord-329840-f3dsu36p	37	17	of	of	IN
cord-329840-f3dsu36p	37	18	viral	viral	JJ
cord-329840-f3dsu36p	37	19	proteins	protein	NNS
cord-329840-f3dsu36p	37	20	needed	need	VBN
cord-329840-f3dsu36p	37	21	for	for	IN
cord-329840-f3dsu36p	37	22	virus	virus	NN
cord-329840-f3dsu36p	37	23	entry	entry	NN
cord-329840-f3dsu36p	37	24	into	into	IN
cord-329840-f3dsu36p	37	25	host	host	NN
cord-329840-f3dsu36p	37	26	cells	cell	NNS
cord-329840-f3dsu36p	37	27	.	.	.
cord-329840-f3dsu36p	38	1	In	in	IN
cord-329840-f3dsu36p	38	2	the	the	DT
cord-329840-f3dsu36p	38	3	backdrop	backdrop	NN
cord-329840-f3dsu36p	38	4	of	of	IN
cord-329840-f3dsu36p	38	5	significant	significant	JJ
cord-329840-f3dsu36p	38	6	mortality	mortality	NN
cord-329840-f3dsu36p	38	7	rate	rate	NN
cord-329840-f3dsu36p	38	8	for	for	IN
cord-329840-f3dsu36p	38	9	SARS	SARS	NNP
cord-329840-f3dsu36p	38	10	-	-	HYPH
cord-329840-f3dsu36p	38	11	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	38	12	(	(	-LRB-
cord-329840-f3dsu36p	38	13	hereinafter	hereinafter	NNP
cord-329840-f3dsu36p	38	14	referred	refer	VBD
cord-329840-f3dsu36p	38	15	to	to	IN
cord-329840-f3dsu36p	38	16	as	as	IN
cord-329840-f3dsu36p	38	17	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	38	18	)	)	-RRB-
cord-329840-f3dsu36p	38	19	infection	infection	NN
cord-329840-f3dsu36p	38	20	,	,	,
cord-329840-f3dsu36p	38	21	it	-PRON-	PRP
cord-329840-f3dsu36p	38	22	is	be	VBZ
cord-329840-f3dsu36p	38	23	important	important	JJ
cord-329840-f3dsu36p	38	24	to	to	TO
cord-329840-f3dsu36p	38	25	know	know	VB
cord-329840-f3dsu36p	38	26	if	if	IN
cord-329840-f3dsu36p	38	27	the	the	DT
cord-329840-f3dsu36p	38	28	thiol	thiol	NN
cord-329840-f3dsu36p	38	29	-	-	HYPH
cord-329840-f3dsu36p	38	30	disulfide	disulfide	NN
cord-329840-f3dsu36p	38	31	balance	balance	NN
cord-329840-f3dsu36p	38	32	plays	play	VBZ
cord-329840-f3dsu36p	38	33	any	any	DT
cord-329840-f3dsu36p	38	34	role	role	NN
cord-329840-f3dsu36p	38	35	on	on	IN
cord-329840-f3dsu36p	38	36	the	the	DT
cord-329840-f3dsu36p	38	37	binding	binding	NN
cord-329840-f3dsu36p	38	38	of	of	IN
cord-329840-f3dsu36p	38	39	the	the	DT
cord-329840-f3dsu36p	38	40	spike	spike	NN
cord-329840-f3dsu36p	38	41	glycoprotein	glycoprotein	NN
cord-329840-f3dsu36p	38	42	on	on	RP
cord-329840-f3dsu36p	38	43	to	to	IN
cord-329840-f3dsu36p	38	44	the	the	DT
cord-329840-f3dsu36p	38	45	host	host	NN
cord-329840-f3dsu36p	38	46	cell	cell	NN
cord-329840-f3dsu36p	38	47	receptor	receptor	NN
cord-329840-f3dsu36p	38	48	protein	protein	NN
cord-329840-f3dsu36p	38	49	ACE2	ACE2	NNP
cord-329840-f3dsu36p	38	50	.	.	.
cord-329840-f3dsu36p	39	1	A	a	DT
cord-329840-f3dsu36p	39	2	recent	recent	JJ
cord-329840-f3dsu36p	39	3	study	study	NN
cord-329840-f3dsu36p	39	4	with	with	IN
cord-329840-f3dsu36p	39	5	the	the	DT
cord-329840-f3dsu36p	39	6	spike	spike	NN
cord-329840-f3dsu36p	39	7	glycoprotein	glycoprotein	NN
cord-329840-f3dsu36p	39	8	of	of	IN
cord-329840-f3dsu36p	39	9	SARS	SARS	NNP
cord-329840-f3dsu36p	39	10	-	-	HYPH
cord-329840-f3dsu36p	39	11	CoV	CoV	NNP
cord-329840-f3dsu36p	39	12	(	(	-LRB-
cord-329840-f3dsu36p	39	13	hereinafter	hereinafter	NNP
cord-329840-f3dsu36p	39	14	referred	refer	VBD
cord-329840-f3dsu36p	39	15	to	to	IN
cord-329840-f3dsu36p	39	16	as	as	IN
cord-329840-f3dsu36p	39	17	CoV	CoV	NNP
cord-329840-f3dsu36p	39	18	)	)	-RRB-
cord-329840-f3dsu36p	39	19	has	have	VBZ
cord-329840-f3dsu36p	39	20	exhibited	exhibit	VBN
cord-329840-f3dsu36p	39	21	a	a	DT
cord-329840-f3dsu36p	39	22	complete	complete	JJ
cord-329840-f3dsu36p	39	23	redox	redox	NN
cord-329840-f3dsu36p	39	24	insensitivity	insensitivity	NN
cord-329840-f3dsu36p	39	25	;	;	:
cord-329840-f3dsu36p	39	26	7	7	CD
cord-329840-f3dsu36p	39	27	despite	despite	IN
cord-329840-f3dsu36p	39	28	the	the	DT
cord-329840-f3dsu36p	39	29	reduction	reduction	NN
cord-329840-f3dsu36p	39	30	of	of	IN
cord-329840-f3dsu36p	39	31	all	all	DT
cord-329840-f3dsu36p	39	32	disulfide	disulfide	JJ
cord-329840-f3dsu36p	39	33	bridges	bridge	NNS
cord-329840-f3dsu36p	39	34	of	of	IN
cord-329840-f3dsu36p	39	35	CoV	cov	NN
cord-329840-f3dsu36p	39	36	to	to	IN
cord-329840-f3dsu36p	39	37	thiols	thiol	NNS
cord-329840-f3dsu36p	39	38	,	,	,
cord-329840-f3dsu36p	39	39	its	-PRON-	PRP$
cord-329840-f3dsu36p	39	40	binding	binding	NN
cord-329840-f3dsu36p	39	41	to	to	IN
cord-329840-f3dsu36p	39	42	ACE2	ACE2	NNP
cord-329840-f3dsu36p	39	43	remained	remain	VBD
cord-329840-f3dsu36p	39	44	unchanged	unchanged	JJ
cord-329840-f3dsu36p	39	45	.	.	.
cord-329840-f3dsu36p	40	1	7	7	CD
cord-329840-f3dsu36p	41	1	However	however	RB
cord-329840-f3dsu36p	41	2	,	,	,
cord-329840-f3dsu36p	41	3	this	this	DT
cord-329840-f3dsu36p	41	4	study	study	NN
cord-329840-f3dsu36p	41	5	did	do	VBD
cord-329840-f3dsu36p	41	6	not	not	RB
cord-329840-f3dsu36p	41	7	probe	probe	VB
cord-329840-f3dsu36p	41	8	the	the	DT
cord-329840-f3dsu36p	41	9	redox	redox	JJ
cord-329840-f3dsu36p	41	10	sensitivity	sensitivity	NN
cord-329840-f3dsu36p	41	11	of	of	IN
cord-329840-f3dsu36p	41	12	ACE2	ACE2	NNP
cord-329840-f3dsu36p	41	13	receptor	receptor	NN
cord-329840-f3dsu36p	41	14	.	.	.
cord-329840-f3dsu36p	42	1	Thus	thus	RB
cord-329840-f3dsu36p	42	2	,	,	,
cord-329840-f3dsu36p	42	3	in	in	IN
cord-329840-f3dsu36p	42	4	the	the	DT
cord-329840-f3dsu36p	42	5	present	present	JJ
cord-329840-f3dsu36p	42	6	study	study	NN
cord-329840-f3dsu36p	42	7	,	,	,
cord-329840-f3dsu36p	42	8	we	-PRON-	PRP
cord-329840-f3dsu36p	42	9	computationally	computationally	RB
cord-329840-f3dsu36p	42	10	investigated	investigate	VBD
cord-329840-f3dsu36p	42	11	the	the	DT
cord-329840-f3dsu36p	42	12	redox	redox	JJ
cord-329840-f3dsu36p	42	13	state	state	NN
cord-329840-f3dsu36p	42	14	of	of	IN
cord-329840-f3dsu36p	42	15	both	both	DT
cord-329840-f3dsu36p	42	16	partners	partner	NNS
cord-329840-f3dsu36p	42	17	(	(	-LRB-
cord-329840-f3dsu36p	42	18	ACE2	ACE2	NNP
cord-329840-f3dsu36p	42	19	and	and	CC
cord-329840-f3dsu36p	42	20	CoV	CoV	NNP
cord-329840-f3dsu36p	42	21	/	/	,
cord-329840-f3dsu36p	42	22	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	42	23	)	)	-RRB-
cord-329840-f3dsu36p	42	24	on	on	IN
cord-329840-f3dsu36p	42	25	their	-PRON-	PRP$
cord-329840-f3dsu36p	42	26	binding	bind	VBG
cord-329840-f3dsu36p	42	27	affinities	affinity	NNS
cord-329840-f3dsu36p	42	28	.	.	.
cord-329840-f3dsu36p	43	1	The	the	DT
cord-329840-f3dsu36p	43	2	structure	structure	NN
cord-329840-f3dsu36p	43	3	of	of	IN
cord-329840-f3dsu36p	43	4	CoV	CoV	NNP
cord-329840-f3dsu36p	43	5	1	1	CD
cord-329840-f3dsu36p	43	6	3	3	CD
cord-329840-f3dsu36p	43	7	and	and	CC
cord-329840-f3dsu36p	43	8	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	43	9	14	14	CD
cord-329840-f3dsu36p	43	10	-	-	SYM
cord-329840-f3dsu36p	43	11	15	15	CD
cord-329840-f3dsu36p	43	12	complexed	complexe	VBN
cord-329840-f3dsu36p	43	13	with	with	IN
cord-329840-f3dsu36p	43	14	ACE2	ACE2	NNP
cord-329840-f3dsu36p	43	15	are	be	VBP
cord-329840-f3dsu36p	43	16	known	know	VBN
cord-329840-f3dsu36p	43	17	and	and	CC
cord-329840-f3dsu36p	43	18	the	the	DT
cord-329840-f3dsu36p	43	19	noncovalent	noncovalent	JJ
cord-329840-f3dsu36p	43	20	interactions	interaction	NNS
cord-329840-f3dsu36p	43	21	at	at	IN
cord-329840-f3dsu36p	43	22	the	the	DT
cord-329840-f3dsu36p	43	23	protein	protein	NN
cord-329840-f3dsu36p	43	24	-	-	HYPH
cord-329840-f3dsu36p	43	25	protein	protein	NN
cord-329840-f3dsu36p	43	26	interface	interface	NN
cord-329840-f3dsu36p	43	27	16	16	CD
cord-329840-f3dsu36p	43	28	have	have	VBP
cord-329840-f3dsu36p	43	29	been	be	VBN
cord-329840-f3dsu36p	43	30	reported	report	VBN
cord-329840-f3dsu36p	43	31	recently	recently	RB
cord-329840-f3dsu36p	43	32	.	.	.
cord-329840-f3dsu36p	44	1	Using	use	VBG
cord-329840-f3dsu36p	44	2	these	these	DT
cord-329840-f3dsu36p	44	3	reported	report	VBN
cord-329840-f3dsu36p	44	4	structures	structure	NNS
cord-329840-f3dsu36p	44	5	,	,	,
cord-329840-f3dsu36p	44	6	molecular	molecular	JJ
cord-329840-f3dsu36p	44	7	dynamics	dynamic	NNS
cord-329840-f3dsu36p	44	8	simulations	simulation	NNS
cord-329840-f3dsu36p	44	9	and	and	CC
cord-329840-f3dsu36p	44	10	electrostatic	electrostatic	JJ
cord-329840-f3dsu36p	44	11	field	field	NN
cord-329840-f3dsu36p	44	12	calculations	calculation	NNS
cord-329840-f3dsu36p	44	13	were	be	VBD
cord-329840-f3dsu36p	44	14	performed	perform	VBN
cord-329840-f3dsu36p	44	15	to	to	TO
cord-329840-f3dsu36p	44	16	explore	explore	VB
cord-329840-f3dsu36p	44	17	the	the	DT
cord-329840-f3dsu36p	44	18	impact	impact	NN
cord-329840-f3dsu36p	44	19	of	of	IN
cord-329840-f3dsu36p	44	20	thioldisulfide	thioldisulfide	JJ
cord-329840-f3dsu36p	44	21	balance	balance	NN
cord-329840-f3dsu36p	44	22	on	on	IN
cord-329840-f3dsu36p	44	23	CoV	CoV	NNP
cord-329840-f3dsu36p	44	24	/	/	,
cord-329840-f3dsu36p	44	25	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	44	26	and	and	CC
cord-329840-f3dsu36p	44	27	ACE2	ACE2	NNP
cord-329840-f3dsu36p	44	28	binding	bind	VBG
cord-329840-f3dsu36p	44	29	affinities	affinity	NNS
cord-329840-f3dsu36p	44	30	.	.	.
cord-329840-f3dsu36p	45	1	The	the	DT
cord-329840-f3dsu36p	45	2	structural	structural	JJ
cord-329840-f3dsu36p	45	3	and	and	CC
cord-329840-f3dsu36p	45	4	dynamical	dynamical	JJ
cord-329840-f3dsu36p	45	5	changes	change	NNS
cord-329840-f3dsu36p	45	6	due	due	IN
cord-329840-f3dsu36p	45	7	to	to	IN
cord-329840-f3dsu36p	45	8	the	the	DT
cord-329840-f3dsu36p	45	9	change	change	NN
cord-329840-f3dsu36p	45	10	in	in	IN
cord-329840-f3dsu36p	45	11	the	the	DT
cord-329840-f3dsu36p	45	12	redox	redox	JJ
cord-329840-f3dsu36p	45	13	states	state	NNS
cord-329840-f3dsu36p	45	14	of	of	IN
cord-329840-f3dsu36p	45	15	cysteines	cysteine	NNS
cord-329840-f3dsu36p	45	16	in	in	IN
cord-329840-f3dsu36p	45	17	the	the	DT
cord-329840-f3dsu36p	45	18	interacting	interact	VBG
cord-329840-f3dsu36p	45	19	proteins	protein	NNS
cord-329840-f3dsu36p	45	20	were	be	VBD
cord-329840-f3dsu36p	45	21	analyzed	analyze	VBN
cord-329840-f3dsu36p	45	22	and	and	CC
cord-329840-f3dsu36p	45	23	their	-PRON-	PRP$
cord-329840-f3dsu36p	45	24	effects	effect	NNS
cord-329840-f3dsu36p	45	25	on	on	IN
cord-329840-f3dsu36p	45	26	binding	bind	VBG
cord-329840-f3dsu36p	45	27	free	free	JJ
cord-329840-f3dsu36p	45	28	energies	energy	NNS
cord-329840-f3dsu36p	45	29	were	be	VBD
cord-329840-f3dsu36p	45	30	studied	study	VBN
cord-329840-f3dsu36p	45	31	.	.	.
cord-329840-f3dsu36p	46	1	The	the	DT
cord-329840-f3dsu36p	46	2	molecular	molecular	JJ
cord-329840-f3dsu36p	46	3	basis	basis	NN
cord-329840-f3dsu36p	46	4	of	of	IN
cord-329840-f3dsu36p	46	5	the	the	DT
cord-329840-f3dsu36p	46	6	binding	binding	NN
cord-329840-f3dsu36p	46	7	of	of	IN
cord-329840-f3dsu36p	46	8	spike	spike	NN
cord-329840-f3dsu36p	46	9	proteins	protein	NNS
cord-329840-f3dsu36p	46	10	to	to	IN
cord-329840-f3dsu36p	46	11	ACE2	ACE2	NNP
cord-329840-f3dsu36p	46	12	is	be	VBZ
cord-329840-f3dsu36p	46	13	known	know	VBN
cord-329840-f3dsu36p	46	14	from	from	IN
cord-329840-f3dsu36p	46	15	X	x	NN
cord-329840-f3dsu36p	46	16	-	-	NN
cord-329840-f3dsu36p	46	17	ray	ray	NN
cord-329840-f3dsu36p	46	18	crystallographic	crystallographic	JJ
cord-329840-f3dsu36p	46	19	(	(	-LRB-
cord-329840-f3dsu36p	46	20	SARS	SARS	NNP
cord-329840-f3dsu36p	46	21	-	-	HYPH
cord-329840-f3dsu36p	46	22	CoV	CoV	NNP
cord-329840-f3dsu36p	46	23	)	)	-RRB-
cord-329840-f3dsu36p	46	24	13	13	CD
cord-329840-f3dsu36p	46	25	and	and	CC
cord-329840-f3dsu36p	46	26	cryo	cryo	NN
cord-329840-f3dsu36p	46	27	-	-	HYPH
cord-329840-f3dsu36p	46	28	electron	electron	NN
cord-329840-f3dsu36p	47	1	microscopic	microscopic	JJ
cord-329840-f3dsu36p	47	2	(	(	-LRB-
cord-329840-f3dsu36p	47	3	SARS	SARS	NNP
cord-329840-f3dsu36p	47	4	-	-	HYPH
cord-329840-f3dsu36p	47	5	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	47	6	)	)	-RRB-
cord-329840-f3dsu36p	48	1	16	16	CD
cord-329840-f3dsu36p	48	2	studies	study	NNS
cord-329840-f3dsu36p	48	3	.	.	.
cord-329840-f3dsu36p	49	1	The	the	DT
cord-329840-f3dsu36p	49	2	sequence	sequence	NN
cord-329840-f3dsu36p	49	3	alignment	alignment	NN
cord-329840-f3dsu36p	49	4	of	of	IN
cord-329840-f3dsu36p	49	5	CoV	CoV	NNP
cord-329840-f3dsu36p	49	6	and	and	CC
cord-329840-f3dsu36p	49	7	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	49	8	spike	spike	NN
cord-329840-f3dsu36p	49	9	proteins	protein	NNS
cord-329840-f3dsu36p	49	10	showed	show	VBD
cord-329840-f3dsu36p	49	11	high	high	JJ
cord-329840-f3dsu36p	49	12	sequence	sequence	NN
cord-329840-f3dsu36p	49	13	identity	identity	NN
cord-329840-f3dsu36p	49	14	(	(	-LRB-
cord-329840-f3dsu36p	49	15	>	>	NFP
cord-329840-f3dsu36p	49	16	75	75	CD
cord-329840-f3dsu36p	49	17	%	%	NN
cord-329840-f3dsu36p	49	18	)	)	-RRB-
cord-329840-f3dsu36p	49	19	indicating	indicate	VBG
cord-329840-f3dsu36p	49	20	that	that	IN
cord-329840-f3dsu36p	49	21	their	-PRON-	PRP$
cord-329840-f3dsu36p	49	22	binding	binding	NN
cord-329840-f3dsu36p	49	23	to	to	IN
cord-329840-f3dsu36p	49	24	ACE2	ACE2	NNP
cord-329840-f3dsu36p	49	25	receptors	receptor	NNS
cord-329840-f3dsu36p	49	26	will	will	MD
cord-329840-f3dsu36p	49	27	be	be	VB
cord-329840-f3dsu36p	49	28	similar	similar	JJ
cord-329840-f3dsu36p	50	1	(	(	-LRB-
cord-329840-f3dsu36p	50	2	Fig	Fig	NNP
cord-329840-f3dsu36p	50	3	.	.	NNP
cord-329840-f3dsu36p	50	4	1	1	CD
cord-329840-f3dsu36p	50	5	)	)	-RRB-
cord-329840-f3dsu36p	50	6	.	.	.
cord-329840-f3dsu36p	51	1	In	in	IN
cord-329840-f3dsu36p	51	2	both	both	DT
cord-329840-f3dsu36p	51	3	bound	bind	VBN
cord-329840-f3dsu36p	51	4	structures	structure	NNS
cord-329840-f3dsu36p	51	5	,	,	,
cord-329840-f3dsu36p	51	6	the	the	DT
cord-329840-f3dsu36p	51	7	RBD	RBD	NNP
cord-329840-f3dsu36p	51	8	of	of	IN
cord-329840-f3dsu36p	51	9	CoV	CoV	NNP
cord-329840-f3dsu36p	51	10	and	and	CC
cord-329840-f3dsu36p	51	11	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	51	12	is	be	VBZ
cord-329840-f3dsu36p	51	13	found	find	VBN
cord-329840-f3dsu36p	51	14	to	to	TO
cord-329840-f3dsu36p	51	15	be	be	VB
cord-329840-f3dsu36p	51	16	complexed	complexe	VBN
cord-329840-f3dsu36p	51	17	with	with	IN
cord-329840-f3dsu36p	51	18	ACE2	ACE2	NNP
cord-329840-f3dsu36p	51	19	(	(	-LRB-
cord-329840-f3dsu36p	51	20	Fig	Fig	NNP
cord-329840-f3dsu36p	51	21	.	.	NNP
cord-329840-f3dsu36p	51	22	2	2	CD
cord-329840-f3dsu36p	51	23	)	)	-RRB-
cord-329840-f3dsu36p	51	24	.	.	.
cord-329840-f3dsu36p	52	1	Both	both	DT
cord-329840-f3dsu36p	52	2	ACE2	ACE2	NNP
cord-329840-f3dsu36p	52	3	and	and	CC
cord-329840-f3dsu36p	52	4	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	52	5	possess	possess	VB
cord-329840-f3dsu36p	52	6	four	four	CD
cord-329840-f3dsu36p	52	7	disulfide	disulfide	JJ
cord-329840-f3dsu36p	52	8	bridges	bridge	NNS
cord-329840-f3dsu36p	52	9	,	,	,
cord-329840-f3dsu36p	52	10	whereas	whereas	IN
cord-329840-f3dsu36p	52	11	CoV	CoV	NNP
cord-329840-f3dsu36p	52	12	subunit	subunit	NN
cord-329840-f3dsu36p	52	13	has	have	VBZ
cord-329840-f3dsu36p	52	14	only	only	RB
cord-329840-f3dsu36p	52	15	two	two	CD
cord-329840-f3dsu36p	52	16	disulfide	disulfide	JJ
cord-329840-f3dsu36p	52	17	linkages	linkage	NNS
cord-329840-f3dsu36p	52	18	(	(	-LRB-
cord-329840-f3dsu36p	52	19	Table	table	NN
cord-329840-f3dsu36p	52	20	1	1	CD
cord-329840-f3dsu36p	52	21	and	and	CC
cord-329840-f3dsu36p	52	22	Fig	Fig	NNP
cord-329840-f3dsu36p	52	23	.	.	.
cord-329840-f3dsu36p	53	1	2a	2a	NNP
cord-329840-f3dsu36p	53	2	and	and	CC
cord-329840-f3dsu36p	53	3	2b	2b	CD
cord-329840-f3dsu36p	53	4	)	)	-RRB-
cord-329840-f3dsu36p	53	5	.	.	.
cord-329840-f3dsu36p	54	1	Two	two	CD
cord-329840-f3dsu36p	54	2	large	large	JJ
cord-329840-f3dsu36p	54	3	helices	helix	NNS
cord-329840-f3dsu36p	54	4	of	of	IN
cord-329840-f3dsu36p	54	5	ACE2	ACE2	NNP
cord-329840-f3dsu36p	54	6	form	form	VBP
cord-329840-f3dsu36p	54	7	a	a	DT
cord-329840-f3dsu36p	54	8	curved	curved	JJ
cord-329840-f3dsu36p	54	9	surface	surface	NN
cord-329840-f3dsu36p	54	10	(	(	-LRB-
cord-329840-f3dsu36p	54	11	Fig	Fig	NNP
cord-329840-f3dsu36p	54	12	.	.	NNP
cord-329840-f3dsu36p	54	13	2	2	CD
cord-329840-f3dsu36p	54	14	,	,	,
cord-329840-f3dsu36p	54	15	illustrated	illustrate	VBN
cord-329840-f3dsu36p	54	16	by	by	IN
cord-329840-f3dsu36p	54	17	the	the	DT
cord-329840-f3dsu36p	54	18	dashed	dash	VBN
cord-329840-f3dsu36p	54	19	curved	curved	JJ
cord-329840-f3dsu36p	54	20	line	line	NN
cord-329840-f3dsu36p	54	21	)	)	-RRB-
cord-329840-f3dsu36p	54	22	that	that	WDT
cord-329840-f3dsu36p	54	23	interacts	interact	VBZ
cord-329840-f3dsu36p	54	24	with	with	IN
cord-329840-f3dsu36p	54	25	the	the	DT
cord-329840-f3dsu36p	54	26	concave	concave	JJ
cord-329840-f3dsu36p	54	27	region	region	NN
cord-329840-f3dsu36p	54	28	of	of	IN
cord-329840-f3dsu36p	54	29	CoV	CoV	NNP
cord-329840-f3dsu36p	54	30	or	or	CC
cord-329840-f3dsu36p	54	31	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	54	32	subunit	subunit	NN
cord-329840-f3dsu36p	54	33	.	.	.
cord-329840-f3dsu36p	55	1	Structural	structural	JJ
cord-329840-f3dsu36p	55	2	change	change	NN
cord-329840-f3dsu36p	55	3	along	along	IN
cord-329840-f3dsu36p	55	4	the	the	DT
cord-329840-f3dsu36p	55	5	trajectory	trajectory	NN
cord-329840-f3dsu36p	55	6	.	.	.
cord-329840-f3dsu36p	56	1	In	in	IN
cord-329840-f3dsu36p	56	2	all	all	DT
cord-329840-f3dsu36p	56	3	cases	case	NNS
cord-329840-f3dsu36p	56	4	,	,	,
cord-329840-f3dsu36p	56	5	the	the	DT
cord-329840-f3dsu36p	56	6	simulation	simulation	NN
cord-329840-f3dsu36p	56	7	started	start	VBD
cord-329840-f3dsu36p	56	8	with	with	IN
cord-329840-f3dsu36p	56	9	an	an	DT
cord-329840-f3dsu36p	56	10	equilibrated	equilibrated	JJ
cord-329840-f3dsu36p	56	11	structure	structure	NN
cord-329840-f3dsu36p	56	12	,	,	,
cord-329840-f3dsu36p	56	13	which	which	WDT
cord-329840-f3dsu36p	56	14	was	be	VBD
cord-329840-f3dsu36p	56	15	obtained	obtain	VBN
cord-329840-f3dsu36p	56	16	after	after	IN
cord-329840-f3dsu36p	56	17	minimizing	minimize	VBG
cord-329840-f3dsu36p	56	18	the	the	DT
cord-329840-f3dsu36p	56	19	neutralized	neutralize	VBN
cord-329840-f3dsu36p	56	20	solvated	solvated	JJ
cord-329840-f3dsu36p	56	21	protein	protein	NN
cord-329840-f3dsu36p	56	22	complex	complex	NN
cord-329840-f3dsu36p	56	23	built	build	VBN
cord-329840-f3dsu36p	56	24	from	from	IN
cord-329840-f3dsu36p	56	25	the	the	DT
cord-329840-f3dsu36p	56	26	experimentally	experimentally	RB
cord-329840-f3dsu36p	56	27	determined	determine	VBN
cord-329840-f3dsu36p	56	28	structures	structure	NNS
cord-329840-f3dsu36p	56	29	.	.	.
cord-329840-f3dsu36p	57	1	The	the	DT
cord-329840-f3dsu36p	57	2	evolution	evolution	NN
cord-329840-f3dsu36p	57	3	of	of	IN
cord-329840-f3dsu36p	57	4	the	the	DT
cord-329840-f3dsu36p	57	5	protein	protein	NN
cord-329840-f3dsu36p	57	6	structure	structure	NN
cord-329840-f3dsu36p	57	7	along	along	IN
cord-329840-f3dsu36p	57	8	the	the	DT
cord-329840-f3dsu36p	57	9	MD	MD	NNP
cord-329840-f3dsu36p	57	10	trajectory	trajectory	NN
cord-329840-f3dsu36p	57	11	was	be	VBD
cord-329840-f3dsu36p	57	12	monitored	monitor	VBN
cord-329840-f3dsu36p	57	13	by	by	IN
cord-329840-f3dsu36p	57	14	calculating	calculate	VBG
cord-329840-f3dsu36p	57	15	the	the	DT
cord-329840-f3dsu36p	57	16	root	root	NN
cord-329840-f3dsu36p	57	17	-	-	HYPH
cord-329840-f3dsu36p	57	18	mean	mean	JJ
cord-329840-f3dsu36p	57	19	-	-	HYPH
cord-329840-f3dsu36p	57	20	square	square	NN
cord-329840-f3dsu36p	57	21	deviation	deviation	NN
cord-329840-f3dsu36p	57	22	(	(	-LRB-
cord-329840-f3dsu36p	57	23	RMSD	RMSD	NNP
cord-329840-f3dsu36p	57	24	)	)	-RRB-
cord-329840-f3dsu36p	57	25	of	of	IN
cord-329840-f3dsu36p	57	26	each	each	DT
cord-329840-f3dsu36p	57	27	structure	structure	NN
cord-329840-f3dsu36p	57	28	from	from	IN
cord-329840-f3dsu36p	57	29	the	the	DT
cord-329840-f3dsu36p	57	30	starting	starting	NN
cord-329840-f3dsu36p	57	31	structure	structure	NN
cord-329840-f3dsu36p	57	32	as	as	IN
cord-329840-f3dsu36p	57	33	a	a	DT
cord-329840-f3dsu36p	57	34	frame	frame	NN
cord-329840-f3dsu36p	57	35	of	of	IN
cord-329840-f3dsu36p	57	36	reference	reference	NN
cord-329840-f3dsu36p	57	37	following	follow	VBG
cord-329840-f3dsu36p	57	38	standard	standard	JJ
cord-329840-f3dsu36p	57	39	procedure	procedure	NN
cord-329840-f3dsu36p	57	40	.	.	.
cord-329840-f3dsu36p	58	1	17	17	CD
cord-329840-f3dsu36p	59	1	Briefly	briefly	RB
cord-329840-f3dsu36p	59	2	,	,	,
cord-329840-f3dsu36p	59	3	during	during	IN
cord-329840-f3dsu36p	59	4	the	the	DT
cord-329840-f3dsu36p	59	5	MD	MD	NNP
cord-329840-f3dsu36p	59	6	simulation	simulation	NN
cord-329840-f3dsu36p	59	7	,	,	,
cord-329840-f3dsu36p	59	8	the	the	DT
cord-329840-f3dsu36p	59	9	protein	protein	NN
cord-329840-f3dsu36p	59	10	coordinates	coordinate	NNS
cord-329840-f3dsu36p	59	11	were	be	VBD
cord-329840-f3dsu36p	59	12	recorded	record	VBN
cord-329840-f3dsu36p	59	13	for	for	IN
cord-329840-f3dsu36p	59	14	every	every	DT
cord-329840-f3dsu36p	59	15	10	10	CD
cord-329840-f3dsu36p	59	16	ps	ps	NNP
cord-329840-f3dsu36p	59	17	interval	interval	NN
cord-329840-f3dsu36p	59	18	and	and	CC
cord-329840-f3dsu36p	59	19	a	a	DT
cord-329840-f3dsu36p	59	20	root	root	NN
cord-329840-f3dsu36p	59	21	-	-	HYPH
cord-329840-f3dsu36p	59	22	mean	mean	JJ
cord-329840-f3dsu36p	59	23	-	-	HYPH
cord-329840-f3dsu36p	59	24	square	square	JJ
cord-329840-f3dsu36p	59	25	-	-	HYPH
cord-329840-f3dsu36p	59	26	deviation	deviation	NN
cord-329840-f3dsu36p	59	27	(	(	-LRB-
cord-329840-f3dsu36p	59	28	RMSD	RMSD	NNP
cord-329840-f3dsu36p	59	29	)	)	-RRB-
cord-329840-f3dsu36p	59	30	of	of	IN
cord-329840-f3dsu36p	59	31	each	each	DT
cord-329840-f3dsu36p	59	32	frame	frame	NN
cord-329840-f3dsu36p	59	33	was	be	VBD
cord-329840-f3dsu36p	59	34	calculated	calculate	VBN
cord-329840-f3dsu36p	59	35	from	from	IN
cord-329840-f3dsu36p	59	36	the	the	DT
cord-329840-f3dsu36p	59	37	average	average	JJ
cord-329840-f3dsu36p	59	38	root	root	NN
cord-329840-f3dsu36p	59	39	-	-	HYPH
cord-329840-f3dsu36p	59	40	mean	mean	NN
cord-329840-f3dsu36p	59	41	-	-	HYPH
cord-329840-f3dsu36p	59	42	square	square	JJ
cord-329840-f3dsu36p	59	43	displacement	displacement	NN
cord-329840-f3dsu36p	59	44	of	of	IN
cord-329840-f3dsu36p	59	45	backbone	backbone	NN
cord-329840-f3dsu36p	59	46	C	c	NN
cord-329840-f3dsu36p	59	47	α	α	NN
cord-329840-f3dsu36p	59	48	atoms	atom	NNS
cord-329840-f3dsu36p	59	49	with	with	IN
cord-329840-f3dsu36p	59	50	respect	respect	NN
cord-329840-f3dsu36p	59	51	to	to	IN
cord-329840-f3dsu36p	59	52	the	the	DT
cord-329840-f3dsu36p	59	53	initial	initial	JJ
cord-329840-f3dsu36p	59	54	structure	structure	NN
cord-329840-f3dsu36p	59	55	.	.	.
cord-329840-f3dsu36p	60	1	Then	then	RB
cord-329840-f3dsu36p	60	2	,	,	,
cord-329840-f3dsu36p	60	3	the	the	DT
cord-329840-f3dsu36p	60	4	RMSD	rmsd	JJ
cord-329840-f3dsu36p	60	5	values	value	NNS
cord-329840-f3dsu36p	60	6	,	,	,
cord-329840-f3dsu36p	60	7	averaged	average	VBD
cord-329840-f3dsu36p	60	8	over	over	IN
cord-329840-f3dsu36p	60	9	conformations	conformation	NNS
cord-329840-f3dsu36p	60	10	stored	store	VBN
cord-329840-f3dsu36p	60	11	during	during	IN
cord-329840-f3dsu36p	60	12	1	1	CD
cord-329840-f3dsu36p	60	13	ns	ns	IN
cord-329840-f3dsu36p	60	14	time	time	NN
cord-329840-f3dsu36p	60	15	,	,	,
cord-329840-f3dsu36p	60	16	were	be	VBD
cord-329840-f3dsu36p	60	17	plotted	plot	VBN
cord-329840-f3dsu36p	60	18	against	against	IN
cord-329840-f3dsu36p	60	19	the	the	DT
cord-329840-f3dsu36p	60	20	simulated	simulated	JJ
cord-329840-f3dsu36p	60	21	time	time	NN
cord-329840-f3dsu36p	61	1	(	(	-LRB-
cord-329840-f3dsu36p	61	2	Fig	Fig	NNP
cord-329840-f3dsu36p	61	3	.	.	.
cord-329840-f3dsu36p	61	4	3	3	CD
cord-329840-f3dsu36p	61	5	)	)	-RRB-
cord-329840-f3dsu36p	61	6	.	.	.
cord-329840-f3dsu36p	62	1	Compared	compare	VBN
cord-329840-f3dsu36p	62	2	to	to	IN
cord-329840-f3dsu36p	62	3	the	the	DT
cord-329840-f3dsu36p	62	4	starting	starting	NN
cord-329840-f3dsu36p	62	5	structure	structure	NN
cord-329840-f3dsu36p	62	6	,	,	,
cord-329840-f3dsu36p	62	7	only	only	RB
cord-329840-f3dsu36p	62	8	a	a	DT
cord-329840-f3dsu36p	62	9	moderate	moderate	JJ
cord-329840-f3dsu36p	62	10	backbone	backbone	NN
cord-329840-f3dsu36p	62	11	fluctuation	fluctuation	NN
cord-329840-f3dsu36p	62	12	was	be	VBD
cord-329840-f3dsu36p	62	13	noted	note	VBN
cord-329840-f3dsu36p	62	14	in	in	IN
cord-329840-f3dsu36p	62	15	all	all	DT
cord-329840-f3dsu36p	62	16	protein	protein	NN
cord-329840-f3dsu36p	62	17	complexes	complex	NNS
cord-329840-f3dsu36p	62	18	during	during	IN
cord-329840-f3dsu36p	62	19	20	20	CD
cord-329840-f3dsu36p	62	20	ns	ns	NNP
cord-329840-f3dsu36p	62	21	simulations	simulation	NNS
cord-329840-f3dsu36p	62	22	and	and	CC
cord-329840-f3dsu36p	62	23	the	the	DT
cord-329840-f3dsu36p	62	24	maximum	maximum	NN
cord-329840-f3dsu36p	62	25	of	of	IN
cord-329840-f3dsu36p	62	26	RMSD	RMSD	NNP
cord-329840-f3dsu36p	62	27	was	be	VBD
cord-329840-f3dsu36p	62	28	in	in	IN
cord-329840-f3dsu36p	62	29	the	the	DT
cord-329840-f3dsu36p	62	30	range	range	NN
cord-329840-f3dsu36p	62	31	of	of	IN
cord-329840-f3dsu36p	62	32	2.0	2.0	CD
cord-329840-f3dsu36p	62	33	-	-	HYPH
cord-329840-f3dsu36p	62	34	3.8	3.8	CD
cord-329840-f3dsu36p	62	35	Å	å	NN
cord-329840-f3dsu36p	62	36	(	(	-LRB-
cord-329840-f3dsu36p	62	37	Table	table	NN
cord-329840-f3dsu36p	62	38	2	2	CD
cord-329840-f3dsu36p	62	39	)	)	-RRB-
cord-329840-f3dsu36p	62	40	.	.	.
cord-329840-f3dsu36p	63	1	The	the	DT
cord-329840-f3dsu36p	63	2	evolution	evolution	NN
cord-329840-f3dsu36p	63	3	was	be	VBD
cord-329840-f3dsu36p	63	4	smooth	smooth	JJ
cord-329840-f3dsu36p	63	5	and	and	CC
cord-329840-f3dsu36p	63	6	its	-PRON-	PRP$
cord-329840-f3dsu36p	63	7	stability	stability	NN
cord-329840-f3dsu36p	63	8	was	be	VBD
cord-329840-f3dsu36p	63	9	demonstrated	demonstrate	VBN
cord-329840-f3dsu36p	63	10	by	by	IN
cord-329840-f3dsu36p	63	11	the	the	DT
cord-329840-f3dsu36p	63	12	standard	standard	JJ
cord-329840-f3dsu36p	63	13	deviation	deviation	NN
cord-329840-f3dsu36p	63	14	of	of	IN
cord-329840-f3dsu36p	63	15	the	the	DT
cord-329840-f3dsu36p	63	16	computed	compute	VBN
cord-329840-f3dsu36p	63	17	RMSDs	rmsd	NNS
cord-329840-f3dsu36p	63	18	,	,	,
cord-329840-f3dsu36p	63	19	which	which	WDT
cord-329840-f3dsu36p	63	20	was	be	VBD
cord-329840-f3dsu36p	63	21	less	less	JJR
cord-329840-f3dsu36p	63	22	than	than	IN
cord-329840-f3dsu36p	63	23	0.3	0.3	CD
cord-329840-f3dsu36p	63	24	Å.	Å.	NNP
cord-329840-f3dsu36p	63	25	Taken	take	VBN
cord-329840-f3dsu36p	63	26	together	together	RB
cord-329840-f3dsu36p	63	27	,	,	,
cord-329840-f3dsu36p	63	28	results	result	NNS
cord-329840-f3dsu36p	63	29	of	of	IN
cord-329840-f3dsu36p	63	30	the	the	DT
cord-329840-f3dsu36p	63	31	simulations	simulation	NNS
cord-329840-f3dsu36p	63	32	showed	show	VBD
cord-329840-f3dsu36p	63	33	no	no	DT
cord-329840-f3dsu36p	63	34	unexpected	unexpected	JJ
cord-329840-f3dsu36p	63	35	structural	structural	JJ
cord-329840-f3dsu36p	63	36	deformation	deformation	NN
cord-329840-f3dsu36p	63	37	of	of	IN
cord-329840-f3dsu36p	63	38	the	the	DT
cord-329840-f3dsu36p	63	39	SAR	SAR	NNP
cord-329840-f3dsu36p	63	40	-	-	HYPH
cord-329840-f3dsu36p	63	41	CoV	CoV	NNP
cord-329840-f3dsu36p	63	42	/	/	SYM
cord-329840-f3dsu36p	63	43	CoV-2⋅⋅⋅ACE2	CoV-2⋅⋅⋅ACE2	NNP
cord-329840-f3dsu36p	63	44	complex	complex	NN
cord-329840-f3dsu36p	63	45	in	in	IN
cord-329840-f3dsu36p	63	46	both	both	DT
cord-329840-f3dsu36p	63	47	,	,	,
cord-329840-f3dsu36p	63	48	reduced	reduce	VBN
cord-329840-f3dsu36p	63	49	(	(	-LRB-
cord-329840-f3dsu36p	63	50	thiol	thiol	NN
cord-329840-f3dsu36p	63	51	groups	group	NNS
cord-329840-f3dsu36p	63	52	)	)	-RRB-
cord-329840-f3dsu36p	63	53	and	and	CC
cord-329840-f3dsu36p	63	54	oxidized	oxidize	VBN
cord-329840-f3dsu36p	63	55	(	(	-LRB-
cord-329840-f3dsu36p	63	56	disulfide	disulfide	NN
cord-329840-f3dsu36p	63	57	bonds	bond	NNS
cord-329840-f3dsu36p	63	58	)	)	-RRB-
cord-329840-f3dsu36p	63	59	states	state	NNS
cord-329840-f3dsu36p	63	60	(	(	-LRB-
cord-329840-f3dsu36p	63	61	Table	table	NN
cord-329840-f3dsu36p	63	62	2	2	CD
cord-329840-f3dsu36p	63	63	)	)	-RRB-
cord-329840-f3dsu36p	63	64	.	.	.
cord-329840-f3dsu36p	64	1	Table	table	NN
cord-329840-f3dsu36p	64	2	3	3	CD
cord-329840-f3dsu36p	64	3	)	)	-RRB-
cord-329840-f3dsu36p	64	4	.	.	.
cord-329840-f3dsu36p	65	1	However	however	RB
cord-329840-f3dsu36p	65	2	,	,	,
cord-329840-f3dsu36p	65	3	when	when	WRB
cord-329840-f3dsu36p	65	4	all	all	DT
cord-329840-f3dsu36p	65	5	disulfides	disulfide	NNS
cord-329840-f3dsu36p	65	6	in	in	IN
cord-329840-f3dsu36p	65	7	CoV	CoV	NNP
cord-329840-f3dsu36p	65	8	/	/	,
cord-329840-f3dsu36p	65	9	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	65	10	as	as	RB
cord-329840-f3dsu36p	65	11	well	well	RB
cord-329840-f3dsu36p	65	12	as	as	IN
cord-329840-f3dsu36p	65	13	ACE2	ACE2	NNP
cord-329840-f3dsu36p	65	14	were	be	VBD
cord-329840-f3dsu36p	65	15	reduced	reduce	VBN
cord-329840-f3dsu36p	65	16	to	to	IN
cord-329840-f3dsu36p	65	17	thiols	thiol	NNS
cord-329840-f3dsu36p	65	18	,	,	,
cord-329840-f3dsu36p	65	19	the	the	DT
cord-329840-f3dsu36p	65	20	binding	binding	NN
cord-329840-f3dsu36p	65	21	became	become	VBD
cord-329840-f3dsu36p	65	22	thermodynamically	thermodynamically	RB
cord-329840-f3dsu36p	65	23	unfavorable	unfavorable	JJ
cord-329840-f3dsu36p	65	24	.	.	.
cord-329840-f3dsu36p	66	1	In	in	IN
cord-329840-f3dsu36p	66	2	both	both	DT
cord-329840-f3dsu36p	66	3	cases	case	NNS
cord-329840-f3dsu36p	66	4	,	,	,
cord-329840-f3dsu36p	66	5	the	the	DT
cord-329840-f3dsu36p	66	6	binding	bind	VBG
cord-329840-f3dsu36p	66	7	free	free	JJ
cord-329840-f3dsu36p	66	8	 	 	_SP
cord-329840-f3dsu36p	67	1	The	the	DT
cord-329840-f3dsu36p	67	2	study	study	NN
cord-329840-f3dsu36p	67	3	found	find	VBD
cord-329840-f3dsu36p	67	4	that	that	IN
cord-329840-f3dsu36p	67	5	the	the	DT
cord-329840-f3dsu36p	67	6	reduction	reduction	NN
cord-329840-f3dsu36p	67	7	of	of	IN
cord-329840-f3dsu36p	67	8	all	all	DT
cord-329840-f3dsu36p	67	9	disulfides	disulfide	NNS
cord-329840-f3dsu36p	67	10	into	into	IN
cord-329840-f3dsu36p	67	11	sulfydryl	sulfydryl	NNP
cord-329840-f3dsu36p	67	12	groups	group	NNS
cord-329840-f3dsu36p	67	13	completely	completely	RB
cord-329840-f3dsu36p	67	14	impairs	impair	VBZ
cord-329840-f3dsu36p	67	15	the	the	DT
cord-329840-f3dsu36p	67	16	binding	binding	NN
cord-329840-f3dsu36p	67	17	of	of	IN
cord-329840-f3dsu36p	67	18	SARS	SARS	NNP
cord-329840-f3dsu36p	67	19	-	-	HYPH
cord-329840-f3dsu36p	67	20	CoV	CoV	NNP
cord-329840-f3dsu36p	67	21	/	/	,
cord-329840-f3dsu36p	67	22	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	67	23	spike	spike	NN
cord-329840-f3dsu36p	67	24	protein	protein	NN
cord-329840-f3dsu36p	67	25	to	to	IN
cord-329840-f3dsu36p	67	26	ACE2	ACE2	NNP
cord-329840-f3dsu36p	67	27	.	.	.
cord-329840-f3dsu36p	68	1	This	this	DT
cord-329840-f3dsu36p	68	2	is	be	VBZ
cord-329840-f3dsu36p	68	3	evident	evident	JJ
cord-329840-f3dsu36p	68	4	from	from	IN
cord-329840-f3dsu36p	68	5	the	the	DT
cord-329840-f3dsu36p	68	6	positive	positive	JJ
cord-329840-f3dsu36p	68	7	Gibbs	Gibbs	NNP
cord-329840-f3dsu36p	68	8	energy	energy	NN
cord-329840-f3dsu36p	68	9	of	of	IN
cord-329840-f3dsu36p	68	10	binding	bind	VBG
cord-329840-f3dsu36p	68	11	(	(	-LRB-
cord-329840-f3dsu36p	68	12	∆	∆	FW
cord-329840-f3dsu36p	68	13	bind	bind	VB
cord-329840-f3dsu36p	68	14	G	G	NNP
cord-329840-f3dsu36p	68	15	o	o	NN
cord-329840-f3dsu36p	68	16	)	)	-RRB-
cord-329840-f3dsu36p	68	17	obtained	obtain	VBN
cord-329840-f3dsu36p	68	18	for	for	IN
cord-329840-f3dsu36p	68	19	both	both	DT
cord-329840-f3dsu36p	68	20	CoV	CoV	NNP
cord-329840-f3dsu36p	68	21	ox	ox	NNP
cord-329840-f3dsu36p	68	22	⋅⋅⋅ACE2	⋅⋅⋅ace2	CD
cord-329840-f3dsu36p	68	23	ox	ox	NN
cord-329840-f3dsu36p	68	24	and	and	CC
cord-329840-f3dsu36p	68	25	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	69	1	ox	ox	NNP
cord-329840-f3dsu36p	69	2	⋅⋅⋅ACE2	⋅⋅⋅ace2	CD
cord-329840-f3dsu36p	69	3	ox	ox	NNP
cord-329840-f3dsu36p	69	4	complexes	complex	NNS
cord-329840-f3dsu36p	69	5	.	.	.
cord-329840-f3dsu36p	70	1	When	when	WRB
cord-329840-f3dsu36p	70	2	the	the	DT
cord-329840-f3dsu36p	70	3	disulfides	disulfide	NNS
cord-329840-f3dsu36p	70	4	of	of	IN
cord-329840-f3dsu36p	70	5	only	only	RB
cord-329840-f3dsu36p	70	6	ACE2	ACE2	NNP
cord-329840-f3dsu36p	70	7	were	be	VBD
cord-329840-f3dsu36p	70	8	reduced	reduce	VBN
cord-329840-f3dsu36p	70	9	to	to	IN
cord-329840-f3dsu36p	70	10	sulfydryl	sulfydryl	NNP
cord-329840-f3dsu36p	70	11	groups	group	NNS
cord-329840-f3dsu36p	70	12	,	,	,
cord-329840-f3dsu36p	70	13	the	the	DT
cord-329840-f3dsu36p	70	14	binding	binding	NN
cord-329840-f3dsu36p	70	15	becomes	become	VBZ
cord-329840-f3dsu36p	70	16	weaker	weak	JJR
cord-329840-f3dsu36p	70	17	,	,	,
cord-329840-f3dsu36p	70	18	as	as	IN
cord-329840-f3dsu36p	70	19	the	the	DT
cord-329840-f3dsu36p	70	20	The	the	DT
cord-329840-f3dsu36p	70	21	redox	redox	JJ
cord-329840-f3dsu36p	70	22	environment	environment	NN
cord-329840-f3dsu36p	70	23	of	of	IN
cord-329840-f3dsu36p	70	24	cell	cell	NN
cord-329840-f3dsu36p	70	25	surface	surface	NN
cord-329840-f3dsu36p	70	26	receptors	receptor	NNS
cord-329840-f3dsu36p	70	27	is	be	VBZ
cord-329840-f3dsu36p	70	28	regulated	regulate	VBN
cord-329840-f3dsu36p	70	29	by	by	IN
cord-329840-f3dsu36p	70	30	the	the	DT
cord-329840-f3dsu36p	70	31	thiol	thiol	NN
cord-329840-f3dsu36p	70	32	-	-	HYPH
cord-329840-f3dsu36p	70	33	disulfide	disulfide	NN
cord-329840-f3dsu36p	70	34	equilibrium	equilibrium	NN
cord-329840-f3dsu36p	70	35	in	in	IN
cord-329840-f3dsu36p	70	36	the	the	DT
cord-329840-f3dsu36p	70	37	extracellular	extracellular	JJ
cord-329840-f3dsu36p	70	38	region	region	NN
cord-329840-f3dsu36p	70	39	.	.	.
cord-329840-f3dsu36p	71	1	12	12	CD
cord-329840-f3dsu36p	71	2	,	,	,
cord-329840-f3dsu36p	71	3	18	18	CD
cord-329840-f3dsu36p	71	4	This	this	DT
cord-329840-f3dsu36p	71	5	is	be	VBZ
cord-329840-f3dsu36p	71	6	maintained	maintain	VBN
cord-329840-f3dsu36p	71	7	by	by	IN
cord-329840-f3dsu36p	71	8	glutathione	glutathione	NN
cord-329840-f3dsu36p	71	9	transporters	transporter	NNS
cord-329840-f3dsu36p	71	10	,	,	,
cord-329840-f3dsu36p	71	11	19	19	CD
cord-329840-f3dsu36p	71	12	a	a	DT
cord-329840-f3dsu36p	71	13	number	number	NN
cord-329840-f3dsu36p	71	14	of	of	IN
cord-329840-f3dsu36p	71	15	oxidoreductases	oxidoreductase	NNS
cord-329840-f3dsu36p	71	16	12	12	CD
cord-329840-f3dsu36p	71	17	including	include	VBG
cord-329840-f3dsu36p	71	18	protein	protein	NN
cord-329840-f3dsu36p	71	19	disulfide	disulfide	NN
cord-329840-f3dsu36p	71	20	isomerase	isomerase	NN
cord-329840-f3dsu36p	71	21	,	,	,
cord-329840-f3dsu36p	71	22	8	8	CD
cord-329840-f3dsu36p	71	23	and	and	CC
cord-329840-f3dsu36p	71	24	several	several	JJ
cord-329840-f3dsu36p	71	25	redox	redox	NN
cord-329840-f3dsu36p	71	26	switches	switch	NNS
cord-329840-f3dsu36p	71	27	.	.	.
cord-329840-f3dsu36p	72	1	12	12	CD
cord-329840-f3dsu36p	73	1	Under	under	IN
cord-329840-f3dsu36p	73	2	oxidative	oxidative	JJ
cord-329840-f3dsu36p	73	3	stress	stress	NN
cord-329840-f3dsu36p	73	4	,	,	,
cord-329840-f3dsu36p	73	5	the	the	DT
cord-329840-f3dsu36p	73	6	extracellular	extracellular	JJ
cord-329840-f3dsu36p	73	7	environment	environment	NN
cord-329840-f3dsu36p	73	8	becomes	become	VBZ
cord-329840-f3dsu36p	73	9	oxidation	oxidation	NN
cord-329840-f3dsu36p	73	10	-	-	HYPH
cord-329840-f3dsu36p	73	11	prone	prone	JJ
cord-329840-f3dsu36p	73	12	resulting	result	VBG
cord-329840-f3dsu36p	73	13	more	more	JJR
cord-329840-f3dsu36p	73	14	disulfide	disulfide	JJ
cord-329840-f3dsu36p	73	15	formation	formation	NN
cord-329840-f3dsu36p	73	16	on	on	IN
cord-329840-f3dsu36p	73	17	protein	protein	NN
cord-329840-f3dsu36p	73	18	surfaces	surface	NNS
cord-329840-f3dsu36p	73	19	.	.	.
cord-329840-f3dsu36p	74	1	12	12	CD
cord-329840-f3dsu36p	75	1	Therefore	therefore	RB
cord-329840-f3dsu36p	75	2	,	,	,
cord-329840-f3dsu36p	75	3	under	under	IN
cord-329840-f3dsu36p	75	4	severe	severe	JJ
cord-329840-f3dsu36p	75	5	oxidative	oxidative	JJ
cord-329840-f3dsu36p	75	6	stress	stress	NN
cord-329840-f3dsu36p	75	7	,	,	,
cord-329840-f3dsu36p	75	8	the	the	DT
cord-329840-f3dsu36p	75	9	cell	cell	NN
cord-329840-f3dsu36p	75	10	surface	surface	NN
cord-329840-f3dsu36p	75	11	receptor	receptor	NN
cord-329840-f3dsu36p	75	12	ACE2	ACE2	NNP
cord-329840-f3dsu36p	75	13	and	and	CC
cord-329840-f3dsu36p	75	14	RBD	RBD	NNP
cord-329840-f3dsu36p	75	15	of	of	IN
cord-329840-f3dsu36p	75	16	the	the	DT
cord-329840-f3dsu36p	75	17	intruding	intrude	VBG
cord-329840-f3dsu36p	75	18	viral	viral	JJ
cord-329840-f3dsu36p	75	19	spike	spike	NN
cord-329840-f3dsu36p	75	20	protein	protein	NN
cord-329840-f3dsu36p	75	21	are	be	VBP
cord-329840-f3dsu36p	75	22	likely	likely	JJ
cord-329840-f3dsu36p	75	23	to	to	TO
cord-329840-f3dsu36p	75	24	be	be	VB
cord-329840-f3dsu36p	75	25	present	present	JJ
cord-329840-f3dsu36p	75	26	in	in	IN
cord-329840-f3dsu36p	75	27	its	-PRON-	PRP$
cord-329840-f3dsu36p	75	28	oxidized	oxidize	VBN
cord-329840-f3dsu36p	75	29	form	form	NN
cord-329840-f3dsu36p	75	30	having	have	VBG
cord-329840-f3dsu36p	75	31	predominantly	predominantly	RB
cord-329840-f3dsu36p	75	32	disulfide	disulfide	JJ
cord-329840-f3dsu36p	75	33	linkages	linkage	NNS
cord-329840-f3dsu36p	75	34	.	.	.
cord-329840-f3dsu36p	76	1	This	this	DT
cord-329840-f3dsu36p	76	2	computational	computational	JJ
cord-329840-f3dsu36p	76	3	study	study	NN
cord-329840-f3dsu36p	76	4	shows	show	VBZ
cord-329840-f3dsu36p	76	5	that	that	IN
cord-329840-f3dsu36p	76	6	under	under	IN
cord-329840-f3dsu36p	76	7	oxidative	oxidative	JJ
cord-329840-f3dsu36p	76	8	stress	stress	NN
cord-329840-f3dsu36p	76	9	,	,	,
cord-329840-f3dsu36p	76	10	the	the	DT
cord-329840-f3dsu36p	76	11	lack	lack	NN
cord-329840-f3dsu36p	76	12	of	of	IN
cord-329840-f3dsu36p	76	13	reducing	reduce	VBG
cord-329840-f3dsu36p	76	14	environment	environment	NN
cord-329840-f3dsu36p	76	15	would	would	MD
cord-329840-f3dsu36p	76	16	result	result	VB
cord-329840-f3dsu36p	76	17	in	in	IN
cord-329840-f3dsu36p	76	18	significantly	significantly	RB
cord-329840-f3dsu36p	76	19	favorable	favorable	JJ
cord-329840-f3dsu36p	76	20	binding	binding	NN
cord-329840-f3dsu36p	76	21	of	of	IN
cord-329840-f3dsu36p	76	22	the	the	DT
cord-329840-f3dsu36p	76	23	viral	viral	JJ
cord-329840-f3dsu36p	76	24	protein	protein	NN
cord-329840-f3dsu36p	76	25	on	on	IN
cord-329840-f3dsu36p	76	26	the	the	DT
cord-329840-f3dsu36p	76	27	cell	cell	NN
cord-329840-f3dsu36p	76	28	surface	surface	NN
cord-329840-f3dsu36p	76	29	ACE2	ACE2	NNP
cord-329840-f3dsu36p	76	30	.	.	.
cord-329840-f3dsu36p	77	1	In	in	IN
cord-329840-f3dsu36p	77	2	terms	term	NNS
cord-329840-f3dsu36p	77	3	of	of	IN
cord-329840-f3dsu36p	77	4	energetics	energetic	NNS
cord-329840-f3dsu36p	77	5	,	,	,
cord-329840-f3dsu36p	77	6	this	this	DT
cord-329840-f3dsu36p	77	7	computational	computational	JJ
cord-329840-f3dsu36p	77	8	study	study	NN
cord-329840-f3dsu36p	77	9	demonstrates	demonstrate	VBZ
cord-329840-f3dsu36p	77	10	that	that	IN
cord-329840-f3dsu36p	77	11	the	the	DT
cord-329840-f3dsu36p	77	12	oxidized	oxidize	VBN
cord-329840-f3dsu36p	77	13	form	form	NN
cord-329840-f3dsu36p	77	14	of	of	IN
cord-329840-f3dsu36p	77	15	proteins	protein	NNS
cord-329840-f3dsu36p	77	16	with	with	IN
cord-329840-f3dsu36p	77	17	disulfide	disulfide	JJ
cord-329840-f3dsu36p	77	18	bridges	bridge	NNS
cord-329840-f3dsu36p	77	19	would	would	MD
cord-329840-f3dsu36p	77	20	cause	cause	VB
cord-329840-f3dsu36p	77	21	a	a	DT
cord-329840-f3dsu36p	77	22	50	50	CD
cord-329840-f3dsu36p	77	23	kcal	kcal	NN
cord-329840-f3dsu36p	77	24	/	/	SYM
cord-329840-f3dsu36p	77	25	mol	mol	NN
cord-329840-f3dsu36p	77	26	of	of	IN
cord-329840-f3dsu36p	77	27	decrease	decrease	NN
cord-329840-f3dsu36p	77	28	in	in	IN
cord-329840-f3dsu36p	77	29	Gibbs	Gibbs	NNP
cord-329840-f3dsu36p	77	30	binding	bind	VBG
cord-329840-f3dsu36p	77	31	free	free	JJ
cord-329840-f3dsu36p	77	32	energy	energy	NN
cord-329840-f3dsu36p	77	33	.	.	.
cord-329840-f3dsu36p	78	1	Furthermore	furthermore	RB
cord-329840-f3dsu36p	78	2	,	,	,
cord-329840-f3dsu36p	78	3	ACE2	ACE2	NNP
cord-329840-f3dsu36p	78	4	,	,	,
cord-329840-f3dsu36p	78	5	which	which	WDT
cord-329840-f3dsu36p	78	6	the	the	DT
cord-329840-f3dsu36p	78	7	viral	viral	JJ
cord-329840-f3dsu36p	78	8	spike	spike	NN
cord-329840-f3dsu36p	78	9	proteins	protein	NNS
cord-329840-f3dsu36p	78	10	latch	latch	VBP
cord-329840-f3dsu36p	78	11	on	on	RP
cord-329840-f3dsu36p	78	12	to	to	IN
cord-329840-f3dsu36p	78	13	,	,	,
cord-329840-f3dsu36p	78	14	is	be	VBZ
cord-329840-f3dsu36p	78	15	known	know	VBN
cord-329840-f3dsu36p	78	16	to	to	TO
cord-329840-f3dsu36p	78	17	be	be	VB
cord-329840-f3dsu36p	78	18	a	a	DT
cord-329840-f3dsu36p	78	19	key	key	JJ
cord-329840-f3dsu36p	78	20	player	player	NN
cord-329840-f3dsu36p	78	21	in	in	IN
cord-329840-f3dsu36p	78	22	the	the	DT
cord-329840-f3dsu36p	78	23	remedial	remedial	NN
cord-329840-f3dsu36p	78	24	of	of	IN
cord-329840-f3dsu36p	78	25	oxidative	oxidative	JJ
cord-329840-f3dsu36p	78	26	stress	stress	NN
cord-329840-f3dsu36p	78	27	.	.	.
cord-329840-f3dsu36p	79	1	20	20	CD
cord-329840-f3dsu36p	79	2	Binding	bind	VBG
cord-329840-f3dsu36p	79	3	of	of	IN
cord-329840-f3dsu36p	79	4	the	the	DT
cord-329840-f3dsu36p	79	5	viral	viral	JJ
cord-329840-f3dsu36p	79	6	protein	protein	NN
cord-329840-f3dsu36p	79	7	will	will	MD
cord-329840-f3dsu36p	79	8	prevent	prevent	VB
cord-329840-f3dsu36p	79	9	the	the	DT
cord-329840-f3dsu36p	79	10	key	key	JJ
cord-329840-f3dsu36p	79	11	catalytic	catalytic	JJ
cord-329840-f3dsu36p	79	12	function	function	NN
cord-329840-f3dsu36p	79	13	of	of	IN
cord-329840-f3dsu36p	79	14	ACE2	ACE2	NNP
cord-329840-f3dsu36p	79	15	of	of	IN
cord-329840-f3dsu36p	79	16	converting	convert	VBG
cord-329840-f3dsu36p	79	17	angiotensin	angiotensin	NN
cord-329840-f3dsu36p	79	18	2	2	CD
cord-329840-f3dsu36p	79	19	(	(	-LRB-
cord-329840-f3dsu36p	79	20	a	a	DT
cord-329840-f3dsu36p	79	21	strong	strong	JJ
cord-329840-f3dsu36p	79	22	activator	activator	NN
cord-329840-f3dsu36p	79	23	of	of	IN
cord-329840-f3dsu36p	79	24	oxidative	oxidative	JJ
cord-329840-f3dsu36p	79	25	stress	stress	NN
cord-329840-f3dsu36p	79	26	)	)	-RRB-
cord-329840-f3dsu36p	79	27	to	to	IN
cord-329840-f3dsu36p	79	28	angiotensin	angiotensin	NN
cord-329840-f3dsu36p	79	29	1	1	CD
cord-329840-f3dsu36p	79	30	-	-	SYM
cord-329840-f3dsu36p	79	31	7	7	CD
cord-329840-f3dsu36p	79	32	thereby	thereby	RB
cord-329840-f3dsu36p	79	33	creating	create	VBG
cord-329840-f3dsu36p	79	34	a	a	DT
cord-329840-f3dsu36p	79	35	vicious	vicious	JJ
cord-329840-f3dsu36p	79	36	circle	circle	NN
cord-329840-f3dsu36p	79	37	of	of	IN
cord-329840-f3dsu36p	79	38	enhanced	enhance	VBN
cord-329840-f3dsu36p	79	39	viral	viral	JJ
cord-329840-f3dsu36p	79	40	attack	attack	NN
cord-329840-f3dsu36p	79	41	.	.	.
cord-329840-f3dsu36p	80	1	In	in	IN
cord-329840-f3dsu36p	80	2	summary	summary	NN
cord-329840-f3dsu36p	80	3	,	,	,
cord-329840-f3dsu36p	80	4	the	the	DT
cord-329840-f3dsu36p	80	5	present	present	JJ
cord-329840-f3dsu36p	80	6	study	study	NN
cord-329840-f3dsu36p	80	7	demonstrates	demonstrate	VBZ
cord-329840-f3dsu36p	80	8	1	1	CD
cord-329840-f3dsu36p	80	9	0	0	NFP
cord-329840-f3dsu36p	80	10	that	that	IN
cord-329840-f3dsu36p	80	11	the	the	DT
cord-329840-f3dsu36p	80	12	absence	absence	NN
cord-329840-f3dsu36p	80	13	of	of	IN
cord-329840-f3dsu36p	80	14	or	or	CC
cord-329840-f3dsu36p	80	15	reduced	reduce	VBN
cord-329840-f3dsu36p	80	16	oxidative	oxidative	JJ
cord-329840-f3dsu36p	80	17	stress	stress	NN
cord-329840-f3dsu36p	80	18	would	would	MD
cord-329840-f3dsu36p	80	19	have	have	VB
cord-329840-f3dsu36p	80	20	a	a	DT
cord-329840-f3dsu36p	80	21	significant	significant	JJ
cord-329840-f3dsu36p	80	22	beneficial	beneficial	JJ
cord-329840-f3dsu36p	80	23	effect	effect	NN
cord-329840-f3dsu36p	80	24	during	during	IN
cord-329840-f3dsu36p	80	25	early	early	JJ
cord-329840-f3dsu36p	80	26	stage	stage	NN
cord-329840-f3dsu36p	80	27	of	of	IN
cord-329840-f3dsu36p	80	28	viral	viral	JJ
cord-329840-f3dsu36p	80	29	infection	infection	NN
cord-329840-f3dsu36p	80	30	by	by	IN
cord-329840-f3dsu36p	80	31	preventing	prevent	VBG
cord-329840-f3dsu36p	80	32	viral	viral	JJ
cord-329840-f3dsu36p	80	33	protein	protein	NN
cord-329840-f3dsu36p	80	34	binding	bind	VBG
cord-329840-f3dsu36p	80	35	on	on	IN
cord-329840-f3dsu36p	80	36	the	the	DT
cord-329840-f3dsu36p	80	37	host	host	NN
cord-329840-f3dsu36p	80	38	cells	cell	NNS
cord-329840-f3dsu36p	80	39	.	.	.
cord-329840-f3dsu36p	81	1	Computational	Computational	NNP
cord-329840-f3dsu36p	81	2	Setup	Setup	NNP
cord-329840-f3dsu36p	81	3	.	.	.
cord-329840-f3dsu36p	82	1	Setting	set	VBG
cord-329840-f3dsu36p	82	2	up	up	RP
cord-329840-f3dsu36p	82	3	of	of	IN
cord-329840-f3dsu36p	82	4	protein	protein	NN
cord-329840-f3dsu36p	82	5	systems	system	NNS
cord-329840-f3dsu36p	82	6	and	and	CC
cord-329840-f3dsu36p	82	7	all	all	DT
cord-329840-f3dsu36p	82	8	structural	structural	JJ
cord-329840-f3dsu36p	82	9	manipulations	manipulation	NNS
cord-329840-f3dsu36p	82	10	were	be	VBD
cord-329840-f3dsu36p	82	11	carried	carry	VBN
cord-329840-f3dsu36p	82	12	out	out	RP
cord-329840-f3dsu36p	82	13	using	use	VBG
cord-329840-f3dsu36p	82	14	Visual	Visual	NNP
cord-329840-f3dsu36p	82	15	Molecular	Molecular	NNP
cord-329840-f3dsu36p	82	16	Dynamics	Dynamics	NNP
cord-329840-f3dsu36p	82	17	(	(	-LRB-
cord-329840-f3dsu36p	82	18	VMD	VMD	NNP
cord-329840-f3dsu36p	82	19	)	)	-RRB-
cord-329840-f3dsu36p	82	20	.	.	.
cord-329840-f3dsu36p	83	1	21	21	CD
cord-329840-f3dsu36p	84	1	Disulfide	disulfide	JJ
cord-329840-f3dsu36p	84	2	groups	group	NNS
cord-329840-f3dsu36p	84	3	were	be	VBD
cord-329840-f3dsu36p	84	4	modified	modify	VBN
cord-329840-f3dsu36p	84	5	to	to	IN
cord-329840-f3dsu36p	84	6	thiols	thiol	NNS
cord-329840-f3dsu36p	84	7	during	during	IN
cord-329840-f3dsu36p	84	8	setting	set	VBG
cord-329840-f3dsu36p	84	9	up	up	RP
cord-329840-f3dsu36p	84	10	of	of	IN
cord-329840-f3dsu36p	84	11	structures	structure	NNS
cord-329840-f3dsu36p	84	12	using	use	VBG
cord-329840-f3dsu36p	84	13	standard	standard	JJ
cord-329840-f3dsu36p	84	14	VMD	VMD	NNP
cord-329840-f3dsu36p	84	15	scripts	script	NNS
cord-329840-f3dsu36p	84	16	.	.	.
cord-329840-f3dsu36p	85	1	Molecular	molecular	JJ
cord-329840-f3dsu36p	85	2	optimization	optimization	NN
cord-329840-f3dsu36p	85	3	and	and	CC
cord-329840-f3dsu36p	85	4	dynamics	dynamic	NNS
cord-329840-f3dsu36p	85	5	(	(	-LRB-
cord-329840-f3dsu36p	85	6	MD	MD	NNP
cord-329840-f3dsu36p	85	7	)	)	-RRB-
cord-329840-f3dsu36p	85	8	simulations	simulation	NNS
cord-329840-f3dsu36p	85	9	were	be	VBD
cord-329840-f3dsu36p	85	10	carried	carry	VBN
cord-329840-f3dsu36p	85	11	out	out	RP
cord-329840-f3dsu36p	85	12	using	use	VBG
cord-329840-f3dsu36p	85	13	Nanoscale	Nanoscale	NNP
cord-329840-f3dsu36p	85	14	Molecular	Molecular	NNP
cord-329840-f3dsu36p	85	15	Dynamics	Dynamics	NNP
cord-329840-f3dsu36p	85	16	(	(	-LRB-
cord-329840-f3dsu36p	85	17	NAMD	NAMD	NNP
cord-329840-f3dsu36p	85	18	)	)	-RRB-
cord-329840-f3dsu36p	85	19	package	package	NN
cord-329840-f3dsu36p	85	20	using	use	VBG
cord-329840-f3dsu36p	85	21	CHARMM36	CHARMM36	NNP
cord-329840-f3dsu36p	85	22	force	force	NN
cord-329840-f3dsu36p	85	23	field	field	NN
cord-329840-f3dsu36p	85	24	.	.	.
cord-329840-f3dsu36p	86	1	[	[	-LRB-
cord-329840-f3dsu36p	86	2	22	22	CD
cord-329840-f3dsu36p	86	3	]	]	-RRB-
cord-329840-f3dsu36p	86	4	[	[	-LRB-
cord-329840-f3dsu36p	86	5	23	23	CD
cord-329840-f3dsu36p	86	6	]	]	-RRB-
cord-329840-f3dsu36p	87	1	[	[	-LRB-
cord-329840-f3dsu36p	87	2	24	24	CD
cord-329840-f3dsu36p	87	3	]	]	-RRB-
cord-329840-f3dsu36p	87	4	[	[	-LRB-
cord-329840-f3dsu36p	87	5	25	25	CD
cord-329840-f3dsu36p	87	6	]	]	-RRB-
cord-329840-f3dsu36p	87	7	[	[	-LRB-
cord-329840-f3dsu36p	87	8	26	26	CD
cord-329840-f3dsu36p	87	9	]	]	-RRB-
cord-329840-f3dsu36p	88	1	During	during	IN
cord-329840-f3dsu36p	88	2	MD	MD	NNP
cord-329840-f3dsu36p	88	3	simulations	simulation	NNS
cord-329840-f3dsu36p	88	4	,	,	,
cord-329840-f3dsu36p	88	5	electrostatic	electrostatic	JJ
cord-329840-f3dsu36p	88	6	energy	energy	NN
cord-329840-f3dsu36p	88	7	calculations	calculation	NNS
cord-329840-f3dsu36p	88	8	were	be	VBD
cord-329840-f3dsu36p	88	9	carried	carry	VBN
cord-329840-f3dsu36p	88	10	out	out	RP
cord-329840-f3dsu36p	88	11	using	use	VBG
cord-329840-f3dsu36p	88	12	particle	particle	NN
cord-329840-f3dsu36p	88	13	mesh	mesh	NN
cord-329840-f3dsu36p	88	14	Ewald	Ewald	NNP
cord-329840-f3dsu36p	88	15	method	method	NN
cord-329840-f3dsu36p	88	16	.	.	.
cord-329840-f3dsu36p	89	1	27	27	CD
cord-329840-f3dsu36p	90	1	Backbone	backbone	NN
cord-329840-f3dsu36p	90	2	root	root	NN
cord-329840-f3dsu36p	90	3	-	-	HYPH
cord-329840-f3dsu36p	90	4	mean	mean	NN
cord-329840-f3dsu36p	90	5	-	-	HYPH
cord-329840-f3dsu36p	90	6	squaredeviation	squaredeviation	NN
cord-329840-f3dsu36p	90	7	(	(	-LRB-
cord-329840-f3dsu36p	90	8	RMSD	RMSD	NNP
cord-329840-f3dsu36p	90	9	)	)	-RRB-
cord-329840-f3dsu36p	90	10	calculations	calculation	NNS
cord-329840-f3dsu36p	90	11	were	be	VBD
cord-329840-f3dsu36p	90	12	performed	perform	VBN
cord-329840-f3dsu36p	90	13	using	use	VBG
cord-329840-f3dsu36p	90	14	VMD	VMD	NNP
cord-329840-f3dsu36p	90	15	.	.	.
cord-329840-f3dsu36p	91	1	Protein	protein	NN
cord-329840-f3dsu36p	91	2	-	-	HYPH
cord-329840-f3dsu36p	91	3	protein	protein	NN
cord-329840-f3dsu36p	91	4	interactions	interaction	NNS
cord-329840-f3dsu36p	91	5	were	be	VBD
cord-329840-f3dsu36p	91	6	studied	study	VBN
cord-329840-f3dsu36p	91	7	using	use	VBG
cord-329840-f3dsu36p	91	8	Adaptive	Adaptive	NNP
cord-329840-f3dsu36p	91	9	-	-	HYPH
cord-329840-f3dsu36p	91	10	Basis	Basis	NNP
cord-329840-f3dsu36p	91	11	Poisson	Poisson	NNP
cord-329840-f3dsu36p	91	12	Boltzmann	Boltzmann	NNP
cord-329840-f3dsu36p	91	13	Solver	Solver	NNP
cord-329840-f3dsu36p	91	14	(	(	-LRB-
cord-329840-f3dsu36p	91	15	APBS	APBS	NNP
cord-329840-f3dsu36p	91	16	)	)	-RRB-
cord-329840-f3dsu36p	91	17	.	.	.
cord-329840-f3dsu36p	92	1	28	28	CD
cord-329840-f3dsu36p	92	2	Electrostatic	electrostatic	JJ
cord-329840-f3dsu36p	92	3	field	field	NN
cord-329840-f3dsu36p	92	4	calculations	calculation	NNS
cord-329840-f3dsu36p	92	5	were	be	VBD
cord-329840-f3dsu36p	92	6	performed	perform	VBN
cord-329840-f3dsu36p	92	7	using	use	VBG
cord-329840-f3dsu36p	92	8	PDB2PQR	PDB2PQR	NNP
cord-329840-f3dsu36p	92	9	program	program	NN
cord-329840-f3dsu36p	92	10	suit	suit	NN
cord-329840-f3dsu36p	92	11	.	.	.
cord-329840-f3dsu36p	93	1	29	29	CD
cord-329840-f3dsu36p	93	2	Molecular	Molecular	NNP
cord-329840-f3dsu36p	93	3	Dynamics	Dynamics	NNPS
cord-329840-f3dsu36p	93	4	Simulations	Simulations	NNPS
cord-329840-f3dsu36p	93	5	.	.	.
cord-329840-f3dsu36p	94	1	All	all	DT
cord-329840-f3dsu36p	94	2	simulations	simulation	NNS
cord-329840-f3dsu36p	94	3	were	be	VBD
cord-329840-f3dsu36p	94	4	performed	perform	VBN
cord-329840-f3dsu36p	94	5	using	use	VBG
cord-329840-f3dsu36p	94	6	the	the	DT
cord-329840-f3dsu36p	94	7	structure	structure	NN
cord-329840-f3dsu36p	94	8	of	of	IN
cord-329840-f3dsu36p	94	9	ACE2	ACE2	NNP
cord-329840-f3dsu36p	94	10	bound	bind	VBN
cord-329840-f3dsu36p	94	11	SARS	SARS	NNP
cord-329840-f3dsu36p	94	12	-	-	HYPH
cord-329840-f3dsu36p	94	13	CoV	CoV	NNP
cord-329840-f3dsu36p	94	14	(	(	-LRB-
cord-329840-f3dsu36p	94	15	PDB	PDB	NNP
cord-329840-f3dsu36p	94	16	entry	entry	NN
cord-329840-f3dsu36p	94	17	:	:	:
cord-329840-f3dsu36p	94	18	3D0	3d0	CD
cord-329840-f3dsu36p	94	19	G	g	NN
cord-329840-f3dsu36p	94	20	)	)	-RRB-
cord-329840-f3dsu36p	94	21	1	1	CD
cord-329840-f3dsu36p	94	22	3	3	CD
cord-329840-f3dsu36p	94	23	and	and	CC
cord-329840-f3dsu36p	94	24	SCAR	SCAR	NNP
cord-329840-f3dsu36p	94	25	-	-	HYPH
cord-329840-f3dsu36p	94	26	CoV-2	cov-2	NN
cord-329840-f3dsu36p	95	1	(	(	-LRB-
cord-329840-f3dsu36p	95	2	PDB	PDB	NNP
cord-329840-f3dsu36p	95	3	entry	entry	NN
cord-329840-f3dsu36p	95	4	:	:	:
cord-329840-f3dsu36p	95	5	6M0J	6m0j	CD
cord-329840-f3dsu36p	95	6	)	)	-RRB-
cord-329840-f3dsu36p	95	7	15	15	CD
cord-329840-f3dsu36p	95	8	.	.	.
cord-329840-f3dsu36p	96	1	In	in	IN
cord-329840-f3dsu36p	96	2	all	all	DT
cord-329840-f3dsu36p	96	3	simulations	simulation	NNS
cord-329840-f3dsu36p	96	4	,	,	,
cord-329840-f3dsu36p	96	5	setup	setup	NN
cord-329840-f3dsu36p	96	6	of	of	IN
cord-329840-f3dsu36p	96	7	protein	protein	NN
cord-329840-f3dsu36p	96	8	complexes	complex	NNS
cord-329840-f3dsu36p	96	9	systems	system	NNS
cord-329840-f3dsu36p	96	10	was	be	VBD
cord-329840-f3dsu36p	96	11	carried	carry	VBN
cord-329840-f3dsu36p	96	12	out	out	RP
cord-329840-f3dsu36p	96	13	following	follow	VBG
cord-329840-f3dsu36p	96	14	protocols	protocol	NNS
cord-329840-f3dsu36p	96	15	used	use	VBD
cord-329840-f3dsu36p	96	16	previous	previous	JJ
cord-329840-f3dsu36p	96	17	studies	study	NNS
cord-329840-f3dsu36p	96	18	from	from	IN
cord-329840-f3dsu36p	96	19	this	this	DT
cord-329840-f3dsu36p	96	20	lab	lab	NN
cord-329840-f3dsu36p	96	21	.	.	.
cord-329840-f3dsu36p	97	1	17	17	CD
cord-329840-f3dsu36p	97	2	,	,	,
cord-329840-f3dsu36p	97	3	30	30	CD
cord-329840-f3dsu36p	97	4	Briefly	briefly	NN
cord-329840-f3dsu36p	97	5	,	,	,
cord-329840-f3dsu36p	97	6	hydrogens	hydrogen	NNS
cord-329840-f3dsu36p	97	7	were	be	VBD
cord-329840-f3dsu36p	97	8	added	add	VBN
cord-329840-f3dsu36p	97	9	using	use	VBG
cord-329840-f3dsu36p	97	10	the	the	DT
cord-329840-f3dsu36p	97	11	HBUILD	HBUILD	NNP
cord-329840-f3dsu36p	97	12	module	module	NN
cord-329840-f3dsu36p	97	13	of	of	IN
cord-329840-f3dsu36p	97	14	CHARMM	CHARMM	NNP
cord-329840-f3dsu36p	97	15	.	.	.
cord-329840-f3dsu36p	98	1	Ionic	ionic	JJ
cord-329840-f3dsu36p	98	2	amino	amino	NN
cord-329840-f3dsu36p	98	3	acid	acid	NN
cord-329840-f3dsu36p	98	4	residues	residue	NNS
cord-329840-f3dsu36p	98	5	were	be	VBD
cord-329840-f3dsu36p	98	6	maintained	maintain	VBN
cord-329840-f3dsu36p	98	7	in	in	IN
cord-329840-f3dsu36p	98	8	a	a	DT
cord-329840-f3dsu36p	98	9	protonation	protonation	JJ
cord-329840-f3dsu36p	98	10	state	state	NN
cord-329840-f3dsu36p	98	11	corresponding	correspond	VBG
cord-329840-f3dsu36p	98	12	to	to	IN
cord-329840-f3dsu36p	98	13	pH	pH	NNP
cord-329840-f3dsu36p	98	14	7	7	CD
cord-329840-f3dsu36p	98	15	.	.	.
cord-329840-f3dsu36p	99	1	The	the	DT
cord-329840-f3dsu36p	99	2	protonation	protonation	JJ
cord-329840-f3dsu36p	99	3	state	state	NN
cord-329840-f3dsu36p	99	4	of	of	IN
cord-329840-f3dsu36p	99	5	histidine	histidine	NN
cord-329840-f3dsu36p	99	6	residues	residue	NNS
cord-329840-f3dsu36p	99	7	was	be	VBD
cord-329840-f3dsu36p	99	8	determined	determine	VBN
cord-329840-f3dsu36p	99	9	by	by	IN
cord-329840-f3dsu36p	99	10	computing	compute	VBG
cord-329840-f3dsu36p	99	11	the	the	DT
cord-329840-f3dsu36p	99	12	pKa	pKa	NNPS
cord-329840-f3dsu36p	99	13	using	use	VBG
cord-329840-f3dsu36p	99	14	Binding	bind	VBG
cord-329840-f3dsu36p	99	15	Free	Free	NNP
cord-329840-f3dsu36p	99	16	Energy	Energy	NNP
cord-329840-f3dsu36p	99	17	Calculations	Calculations	NNPS
cord-329840-f3dsu36p	99	18	.	.	.
cord-329840-f3dsu36p	100	1	Gibbs	Gibbs	NNP
cord-329840-f3dsu36p	100	2	free	free	JJ
cord-329840-f3dsu36p	100	3	energies	energy	NNS
cord-329840-f3dsu36p	100	4	of	of	IN
cord-329840-f3dsu36p	100	5	binding	bind	VBG
cord-329840-f3dsu36p	100	6	between	between	IN
cord-329840-f3dsu36p	100	7	the	the	DT
cord-329840-f3dsu36p	100	8	ACE2	ACE2	NNP
cord-329840-f3dsu36p	100	9	and	and	CC
cord-329840-f3dsu36p	100	10	SARS	SARS	NNP
cord-329840-f3dsu36p	100	11	CoV	CoV	NNP
cord-329840-f3dsu36p	100	12	or	or	CC
cord-329840-f3dsu36p	100	13	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	100	14	proteins	protein	NNS
cord-329840-f3dsu36p	100	15	were	be	VBD
cord-329840-f3dsu36p	100	16	calculated	calculate	VBN
cord-329840-f3dsu36p	100	17	using	use	VBG
cord-329840-f3dsu36p	100	18	APBS	APBS	NNP
cord-329840-f3dsu36p	100	19	using	use	VBG
cord-329840-f3dsu36p	100	20	a	a	DT
cord-329840-f3dsu36p	100	21	standardized	standardized	JJ
cord-329840-f3dsu36p	100	22	method	method	NN
cord-329840-f3dsu36p	100	23	of	of	IN
cord-329840-f3dsu36p	100	24	a	a	DT
cord-329840-f3dsu36p	100	25	treecode	treecode	NNP
cord-329840-f3dsu36p	100	26	-	-	HYPH
cord-329840-f3dsu36p	100	27	accelerated	accelerate	VBN
cord-329840-f3dsu36p	100	28	boundary	boundary	JJ
cord-329840-f3dsu36p	100	29	integral	integral	JJ
cord-329840-f3dsu36p	100	30	Poisson	Poisson	NNP
cord-329840-f3dsu36p	100	31	-	-	HYPH
cord-329840-f3dsu36p	100	32	Boltzmann	Boltzmann	NNP
cord-329840-f3dsu36p	100	33	equation	equation	NN
cord-329840-f3dsu36p	100	34	solver	solver	NN
cord-329840-f3dsu36p	100	35	(	(	-LRB-
cord-329840-f3dsu36p	100	36	TABI	TABI	NNP
cord-329840-f3dsu36p	100	37	-	-	HYPH
cord-329840-f3dsu36p	100	38	PB	PB	NNP
cord-329840-f3dsu36p	100	39	)	)	-RRB-
cord-329840-f3dsu36p	100	40	.	.	.
cord-329840-f3dsu36p	101	1	33	33	CD
cord-329840-f3dsu36p	102	1	In	in	IN
cord-329840-f3dsu36p	102	2	this	this	DT
cord-329840-f3dsu36p	102	3	method	method	NN
cord-329840-f3dsu36p	102	4	,	,	,
cord-329840-f3dsu36p	102	5	the	the	DT
cord-329840-f3dsu36p	102	6	protein	protein	NN
cord-329840-f3dsu36p	102	7	surface	surface	NN
cord-329840-f3dsu36p	102	8	is	be	VBZ
cord-329840-f3dsu36p	102	9	triangulated	triangulate	VBN
cord-329840-f3dsu36p	102	10	,	,	,
cord-329840-f3dsu36p	102	11	and	and	CC
cord-329840-f3dsu36p	102	12	electrostatic	electrostatic	JJ
cord-329840-f3dsu36p	102	13	surface	surface	NN
cord-329840-f3dsu36p	102	14	potentials	potential	NNS
cord-329840-f3dsu36p	102	15	are	be	VBP
cord-329840-f3dsu36p	102	16	computed	compute	VBN
cord-329840-f3dsu36p	102	17	.	.	.
cord-329840-f3dsu36p	103	1	The	the	DT
cord-329840-f3dsu36p	103	2	discretization	discretization	NN
cord-329840-f3dsu36p	103	3	of	of	IN
cord-329840-f3dsu36p	103	4	surface	surface	NN
cord-329840-f3dsu36p	103	5	potentials	potential	NNS
cord-329840-f3dsu36p	103	6	is	be	VBZ
cord-329840-f3dsu36p	103	7	utilized	utilize	VBN
cord-329840-f3dsu36p	103	8	to	to	TO
cord-329840-f3dsu36p	103	9	compute	compute	VB
cord-329840-f3dsu36p	103	10	the	the	DT
cord-329840-f3dsu36p	103	11	net	net	JJ
cord-329840-f3dsu36p	103	12	energy	energy	NN
cord-329840-f3dsu36p	103	13	due	due	IN
cord-329840-f3dsu36p	103	14	to	to	IN
cord-329840-f3dsu36p	103	15	solvation	solvation	NN
cord-329840-f3dsu36p	103	16	as	as	RB
cord-329840-f3dsu36p	103	17	well	well	RB
cord-329840-f3dsu36p	103	18	as	as	IN
cord-329840-f3dsu36p	103	19	electrostatic	electrostatic	JJ
cord-329840-f3dsu36p	103	20	interactions	interaction	NNS
cord-329840-f3dsu36p	103	21	between	between	IN
cord-329840-f3dsu36p	103	22	the	the	DT
cord-329840-f3dsu36p	103	23	two	two	CD
cord-329840-f3dsu36p	103	24	protein	protein	NN
cord-329840-f3dsu36p	103	25	subunits	subunit	NNS
cord-329840-f3dsu36p	103	26	,	,	,
cord-329840-f3dsu36p	103	27	as	as	IN
cord-329840-f3dsu36p	103	28	outlined	outline	VBN
cord-329840-f3dsu36p	103	29	in	in	IN
cord-329840-f3dsu36p	103	30	thermodynamic	thermodynamic	JJ
cord-329840-f3dsu36p	103	31	scheme	scheme	NN
cord-329840-f3dsu36p	103	32	,	,	,
cord-329840-f3dsu36p	103	33	Scheme	scheme	NN
cord-329840-f3dsu36p	103	34	1	1	CD
cord-329840-f3dsu36p	103	35	.	.	.
cord-329840-f3dsu36p	104	1	Following	follow	VBG
cord-329840-f3dsu36p	104	2	Scheme	scheme	NN
cord-329840-f3dsu36p	104	3	1	1	CD
cord-329840-f3dsu36p	104	4	,	,	,
cord-329840-f3dsu36p	104	5	the	the	DT
cord-329840-f3dsu36p	104	6	free	free	JJ
cord-329840-f3dsu36p	104	7	energy	energy	NN
cord-329840-f3dsu36p	104	8	of	of	IN
cord-329840-f3dsu36p	104	9	binding	binding	NN
cord-329840-f3dsu36p	104	10	of	of	IN
cord-329840-f3dsu36p	104	11	the	the	DT
cord-329840-f3dsu36p	104	12	two	two	CD
cord-329840-f3dsu36p	104	13	protein	protein	NN
cord-329840-f3dsu36p	104	14	fragments	fragment	NNS
cord-329840-f3dsu36p	104	15	in	in	IN
cord-329840-f3dsu36p	104	16	water	water	NN
cord-329840-f3dsu36p	104	17	,	,	,
cord-329840-f3dsu36p	104	18	can	can	MD
cord-329840-f3dsu36p	104	19	be	be	VB
cord-329840-f3dsu36p	104	20	expressed	express	VBN
cord-329840-f3dsu36p	104	21	as	as	IN
cord-329840-f3dsu36p	104	22	a	a	DT
cord-329840-f3dsu36p	104	23	sum	sum	NN
cord-329840-f3dsu36p	104	24	of	of	IN
cord-329840-f3dsu36p	104	25	two	two	CD
cord-329840-f3dsu36p	104	26	components	component	NNS
cord-329840-f3dsu36p	104	27	(	(	-LRB-
cord-329840-f3dsu36p	104	28	eq	eq	NNP
cord-329840-f3dsu36p	104	29	.	.	NNP
cord-329840-f3dsu36p	104	30	1	1	LS
cord-329840-f3dsu36p	104	31	)	)	-RRB-
cord-329840-f3dsu36p	104	32	where	where	WRB
cord-329840-f3dsu36p	104	33	the	the	DT
cord-329840-f3dsu36p	104	34	∆	∆	NN
cord-329840-f3dsu36p	104	35	Coul	Coul	NNP
cord-329840-f3dsu36p	104	36	G	G	NNP
cord-329840-f3dsu36p	104	37	represents	represent	VBZ
cord-329840-f3dsu36p	104	38	the	the	DT
cord-329840-f3dsu36p	104	39	Coulombic	Coulombic	NNP
cord-329840-f3dsu36p	104	40	(	(	-LRB-
cord-329840-f3dsu36p	104	41	electrostatic	electrostatic	JJ
cord-329840-f3dsu36p	104	42	)	)	-RRB-
cord-329840-f3dsu36p	104	43	interactions	interaction	NNS
cord-329840-f3dsu36p	104	44	between	between	IN
cord-329840-f3dsu36p	104	45	the	the	DT
cord-329840-f3dsu36p	104	46	proteins	protein	NNS
cord-329840-f3dsu36p	104	47	occurring	occur	VBG
cord-329840-f3dsu36p	104	48	at	at	IN
cord-329840-f3dsu36p	104	49	the	the	DT
cord-329840-f3dsu36p	104	50	protein	protein	NN
cord-329840-f3dsu36p	104	51	-	-	HYPH
cord-329840-f3dsu36p	104	52	protein	protein	NN
cord-329840-f3dsu36p	104	53	interface	interface	NN
cord-329840-f3dsu36p	104	54	(	(	-LRB-
cord-329840-f3dsu36p	104	55	Scheme	scheme	NN
cord-329840-f3dsu36p	104	56	1	1	CD
cord-329840-f3dsu36p	104	57	)	)	-RRB-
cord-329840-f3dsu36p	104	58	and	and	CC
cord-329840-f3dsu36p	105	1	∆	∆	NNP
cord-329840-f3dsu36p	105	2	∆	∆	NNP
cord-329840-f3dsu36p	105	3	solv	solv	NNP
cord-329840-f3dsu36p	105	4	G	G	NNP
cord-329840-f3dsu36p	105	5	is	be	VBZ
cord-329840-f3dsu36p	105	6	the	the	DT
cord-329840-f3dsu36p	105	7	difference	difference	NN
cord-329840-f3dsu36p	105	8	of	of	IN
cord-329840-f3dsu36p	105	9	the	the	DT
cord-329840-f3dsu36p	105	10	solvation	solvation	NN
cord-329840-f3dsu36p	105	11	energies	energy	NNS
cord-329840-f3dsu36p	105	12	between	between	IN
cord-329840-f3dsu36p	105	13	the	the	DT
cord-329840-f3dsu36p	105	14	complex	complex	NN
cord-329840-f3dsu36p	105	15	and	and	CC
cord-329840-f3dsu36p	105	16	the	the	DT
cord-329840-f3dsu36p	105	17	corresponding	correspond	VBG
cord-329840-f3dsu36p	105	18	free	free	JJ
cord-329840-f3dsu36p	105	19	proteins	protein	NNS
cord-329840-f3dsu36p	105	20	:	:	:
cord-329840-f3dsu36p	105	21	However	however	RB
cord-329840-f3dsu36p	105	22	,	,	,
cord-329840-f3dsu36p	105	23	the	the	DT
cord-329840-f3dsu36p	105	24	solvation	solvation	NN
cord-329840-f3dsu36p	105	25	calculation	calculation	NN
cord-329840-f3dsu36p	105	26	used	use	VBN
cord-329840-f3dsu36p	105	27	only	only	JJ
cord-329840-f3dsu36p	105	28	part	part	NN
cord-329840-f3dsu36p	105	29	of	of	IN
cord-329840-f3dsu36p	105	30	the	the	DT
cord-329840-f3dsu36p	105	31	entire	entire	JJ
cord-329840-f3dsu36p	105	32	spike	spike	NN
cord-329840-f3dsu36p	105	33	protein	protein	NN
cord-329840-f3dsu36p	105	34	as	as	RB
cord-329840-f3dsu36p	105	35	well	well	RB
cord-329840-f3dsu36p	105	36	as	as	IN
cord-329840-f3dsu36p	105	37	the	the	DT
cord-329840-f3dsu36p	105	38	ACE2	ACE2	NNP
cord-329840-f3dsu36p	105	39	,	,	,
cord-329840-f3dsu36p	105	40	therefore	therefore	RB
cord-329840-f3dsu36p	105	41	∆	∆	NNP
cord-329840-f3dsu36p	105	42	bind	bind	VB
cord-329840-f3dsu36p	105	43	G	G	NNP
cord-329840-f3dsu36p	105	44	TABI	TABI	NNP
cord-329840-f3dsu36p	105	45	-	-	HYPH
cord-329840-f3dsu36p	105	46	PB	PB	NNP
cord-329840-f3dsu36p	105	47	was	be	VBD
cord-329840-f3dsu36p	105	48	calibrated	calibrate	VBN
cord-329840-f3dsu36p	105	49	by	by	IN
cord-329840-f3dsu36p	105	50	correcting	correct	VBG
cord-329840-f3dsu36p	105	51	∆	∆	NNP
cord-329840-f3dsu36p	105	52	∆	∆	NNP
cord-329840-f3dsu36p	105	53	solv	solv	NN
cord-329840-f3dsu36p	105	54	G	G	NNP
cord-329840-f3dsu36p	105	55	using	use	VBG
cord-329840-f3dsu36p	105	56	experimentally	experimentally	RB
cord-329840-f3dsu36p	105	57	known	know	VBN
cord-329840-f3dsu36p	105	58	binding	bind	VBG
cord-329840-f3dsu36p	105	59	free	free	JJ
cord-329840-f3dsu36p	105	60	energy	energy	NN
cord-329840-f3dsu36p	105	61	of	of	IN
cord-329840-f3dsu36p	105	62	ACE2···CoV-2	ACE2···CoV-2	NNP
cord-329840-f3dsu36p	105	63	:	:	:
cord-329840-f3dsu36p	105	64	where	where	WRB
cord-329840-f3dsu36p	105	65	K	K	NNP
cord-329840-f3dsu36p	105	66	d	d	NNP
cord-329840-f3dsu36p	105	67	is	be	VBZ
cord-329840-f3dsu36p	105	68	the	the	DT
cord-329840-f3dsu36p	105	69	experimental	experimental	JJ
cord-329840-f3dsu36p	105	70	dissociation	dissociation	NN
cord-329840-f3dsu36p	105	71	constant	constant	NN
cord-329840-f3dsu36p	105	72	,	,	,
cord-329840-f3dsu36p	105	73	which	which	WDT
cord-329840-f3dsu36p	105	74	is	be	VBZ
cord-329840-f3dsu36p	105	75	equal	equal	JJ
cord-329840-f3dsu36p	105	76	to	to	IN
cord-329840-f3dsu36p	105	77	37	37	CD
cord-329840-f3dsu36p	105	78	nM.	nm.	NN
cord-329840-f3dsu36p	105	79	16	16	CD
cord-329840-f3dsu36p	106	1	The	the	DT
cord-329840-f3dsu36p	106	2	corrected	correct	VBN
cord-329840-f3dsu36p	106	3	free	free	JJ
cord-329840-f3dsu36p	106	4	energy	energy	NN
cord-329840-f3dsu36p	106	5	of	of	IN
cord-329840-f3dsu36p	106	6	the	the	DT
cord-329840-f3dsu36p	106	7	solvation	solvation	NN
cord-329840-f3dsu36p	106	8	Using	use	VBG
cord-329840-f3dsu36p	106	9	the	the	DT
cord-329840-f3dsu36p	106	10	∆	∆	NN
cord-329840-f3dsu36p	106	11	G	G	NNP
cord-329840-f3dsu36p	106	12	corr	corr	NNP
cord-329840-f3dsu36p	106	13	and	and	CC
cord-329840-f3dsu36p	106	14	eq	eq	NNP
cord-329840-f3dsu36p	106	15	.	.	NNP
cord-329840-f3dsu36p	106	16	4	4	CD
cord-329840-f3dsu36p	106	17	,	,	,
cord-329840-f3dsu36p	106	18	the	the	DT
cord-329840-f3dsu36p	106	19	corrected	correct	VBN
cord-329840-f3dsu36p	106	20	binding	bind	VBG
cord-329840-f3dsu36p	106	21	free	free	JJ
cord-329840-f3dsu36p	106	22	energy	energy	NN
cord-329840-f3dsu36p	106	23	,	,	,
cord-329840-f3dsu36p	106	24	∆	∆	NNP
cord-329840-f3dsu36p	106	25	bind	bind	VBP
cord-329840-f3dsu36p	106	26	G	G	NNP
cord-329840-f3dsu36p	106	27	o	o	NN
cord-329840-f3dsu36p	106	28	of	of	IN
cord-329840-f3dsu36p	106	29	all	all	DT
cord-329840-f3dsu36p	106	30	protein	protein	NN
cord-329840-f3dsu36p	106	31	complexes	complex	NNS
cord-329840-f3dsu36p	106	32	is	be	VBZ
cord-329840-f3dsu36p	106	33	expressed	express	VBN
cord-329840-f3dsu36p	106	34	by	by	IN
cord-329840-f3dsu36p	106	35	As	as	IN
cord-329840-f3dsu36p	106	36	shown	show	VBN
cord-329840-f3dsu36p	106	37	in	in	IN
cord-329840-f3dsu36p	106	38	eq	eq	NNP
cord-329840-f3dsu36p	106	39	.	.	NNP
cord-329840-f3dsu36p	106	40	4	4	CD
cord-329840-f3dsu36p	106	41	,	,	,
cord-329840-f3dsu36p	106	42	the	the	DT
cord-329840-f3dsu36p	106	43	combination	combination	NN
cord-329840-f3dsu36p	106	44	of	of	IN
cord-329840-f3dsu36p	106	45	last	last	JJ
cord-329840-f3dsu36p	106	46	two	two	CD
cord-329840-f3dsu36p	106	47	terms	term	NNS
cord-329840-f3dsu36p	106	48	in	in	IN
cord-329840-f3dsu36p	106	49	eq	eq	NNP
cord-329840-f3dsu36p	106	50	.	.	NNP
cord-329840-f3dsu36p	106	51	5	5	CD
cord-329840-f3dsu36p	106	52	is	be	VBZ
cord-329840-f3dsu36p	106	53	equal	equal	JJ
cord-329840-f3dsu36p	106	54	to	to	IN
cord-329840-f3dsu36p	106	55	∆	∆	NNP
cord-329840-f3dsu36p	106	56	∆	∆	NN
cord-329840-f3dsu36p	106	57	solv	solv	NN
cord-329840-f3dsu36p	106	58	G	G	NNP
cord-329840-f3dsu36p	106	59	corr	corr	NN
cord-329840-f3dsu36p	106	60	.	.	.
cord-329840-f3dsu36p	107	1	Therefore	therefore	RB
cord-329840-f3dsu36p	107	2	,	,	,
cord-329840-f3dsu36p	107	3	eq	eq	NNP
cord-329840-f3dsu36p	107	4	.	.	NNP
cord-329840-f3dsu36p	107	5	5	5	CD
cord-329840-f3dsu36p	107	6	can	can	MD
cord-329840-f3dsu36p	107	7	be	be	VB
cord-329840-f3dsu36p	107	8	simplified	simplify	VBN
cord-329840-f3dsu36p	107	9	as	as	IN
cord-329840-f3dsu36p	107	10	:	:	:
cord-329840-f3dsu36p	107	11	Figure	figure	NN
cord-329840-f3dsu36p	107	12	1	1	CD
cord-329840-f3dsu36p	107	13	.	.	.
cord-329840-f3dsu36p	108	1	Sequence	sequence	NN
cord-329840-f3dsu36p	108	2	alignment	alignment	NN
cord-329840-f3dsu36p	108	3	(	(	-LRB-
cord-329840-f3dsu36p	108	4	generated	generate	VBN
cord-329840-f3dsu36p	108	5	by	by	IN
cord-329840-f3dsu36p	108	6	Clustal	Clustal	NNP
cord-329840-f3dsu36p	108	7	Omega	Omega	NNP
cord-329840-f3dsu36p	108	8	35	35	CD
cord-329840-f3dsu36p	108	9	)	)	-RRB-
cord-329840-f3dsu36p	108	10	between	between	IN
cord-329840-f3dsu36p	108	11	the	the	DT
cord-329840-f3dsu36p	108	12	receptor	receptor	NN
cord-329840-f3dsu36p	108	13	-	-	HYPH
cord-329840-f3dsu36p	108	14	binding	bind	VBG
cord-329840-f3dsu36p	108	15	domain	domain	NN
cord-329840-f3dsu36p	108	16	of	of	IN
cord-329840-f3dsu36p	108	17	SARS	SARS	NNP
cord-329840-f3dsu36p	108	18	-	-	HYPH
cord-329840-f3dsu36p	108	19	CoV	CoV	NNP
cord-329840-f3dsu36p	108	20	and	and	CC
cord-329840-f3dsu36p	108	21	SARS	SARS	NNP
cord-329840-f3dsu36p	108	22	-	-	HYPH
cord-329840-f3dsu36p	108	23	CoV2	cov2	NN
cord-329840-f3dsu36p	108	24	proteins	protein	NNS
cord-329840-f3dsu36p	108	25	.	.	.
cord-329840-f3dsu36p	109	1	The	the	DT
cord-329840-f3dsu36p	109	2	"	"	``
cord-329840-f3dsu36p	109	3	*	*	NFP
cord-329840-f3dsu36p	109	4	"	"	''
cord-329840-f3dsu36p	109	5	represents	represent	VBZ
cord-329840-f3dsu36p	109	6	the	the	DT
cord-329840-f3dsu36p	109	7	identical	identical	JJ
cord-329840-f3dsu36p	109	8	residues	residue	NNS
cord-329840-f3dsu36p	109	9	,	,	,
cord-329840-f3dsu36p	109	10	"	"	''
cord-329840-f3dsu36p	109	11	:	:	:
cord-329840-f3dsu36p	109	12	"	"	``
cord-329840-f3dsu36p	109	13	represents	represent	VBZ
cord-329840-f3dsu36p	109	14	similar	similar	JJ
cord-329840-f3dsu36p	109	15	residues	residue	NNS
cord-329840-f3dsu36p	109	16	,	,	,
cord-329840-f3dsu36p	109	17	and	and	CC
cord-329840-f3dsu36p	109	18	gap	gap	NN
cord-329840-f3dsu36p	109	19	represents	represent	VBZ
cord-329840-f3dsu36p	109	20	dissimilar	dissimilar	JJ
cord-329840-f3dsu36p	109	21	residues	residue	NNS
cord-329840-f3dsu36p	109	22	.	.	.
cord-329840-f3dsu36p	110	1	The	the	DT
cord-329840-f3dsu36p	110	2	cysteine	cysteine	NN
cord-329840-f3dsu36p	110	3	residues	residue	NNS
cord-329840-f3dsu36p	110	4	are	be	VBP
cord-329840-f3dsu36p	110	5	highlighted	highlight	VBN
cord-329840-f3dsu36p	110	6	in	in	IN
cord-329840-f3dsu36p	110	7	yellow	yellow	JJ
cord-329840-f3dsu36p	110	8	.	.	.
cord-329840-f3dsu36p	111	1	RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFK	RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFK	NNP
cord-329840-f3dsu36p	111	2	60	60	CD
cord-329840-f3dsu36p	111	3	CoV	cov	NN
cord-329840-f3dsu36p	111	4	------------------PFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFK	------------------PFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFK	NNP
cord-329840-f3dsu36p	111	5	42	42	CD
cord-329840-f3dsu36p	112	1	*	*	NFP
cord-329840-f3dsu36p	112	2	*	*	NFP
cord-329840-f3dsu36p	112	3	*	*	NFP
cord-329840-f3dsu36p	112	4	*	*	NFP
cord-329840-f3dsu36p	112	5	*	*	NFP
cord-329840-f3dsu36p	112	6	*	*	NFP
cord-329840-f3dsu36p	112	7	*	*	NFP
cord-329840-f3dsu36p	112	8	*	*	NFP
cord-329840-f3dsu36p	112	9	*	*	NFP
cord-329840-f3dsu36p	112	10	:	:	:
cord-329840-f3dsu36p	113	1	*	*	NFP
cord-329840-f3dsu36p	113	2	*	*	NFP
cord-329840-f3dsu36p	113	3	*	*	NFP
cord-329840-f3dsu36p	113	4	*	*	NFP
cord-329840-f3dsu36p	113	5	*	*	NFP
cord-329840-f3dsu36p	113	6	*	*	NFP
cord-329840-f3dsu36p	113	7	:	:	:
cord-329840-f3dsu36p	114	1	*	*	NFP
cord-329840-f3dsu36p	114	2	*	*	NFP
cord-329840-f3dsu36p	114	3	:	:	:
cord-329840-f3dsu36p	115	1	*	*	NFP
cord-329840-f3dsu36p	115	2	*	*	NFP
cord-329840-f3dsu36p	115	3	*	*	NFP
cord-329840-f3dsu36p	115	4	*	*	NFP
cord-329840-f3dsu36p	115	5	*	*	NFP
cord-329840-f3dsu36p	115	6	*	*	NFP
cord-329840-f3dsu36p	115	7	*	*	NFP
cord-329840-f3dsu36p	115	8	*	*	NFP
cord-329840-f3dsu36p	115	9	*	*	NFP
cord-329840-f3dsu36p	115	10	*	*	NFP
cord-329840-f3dsu36p	115	11	*	*	NFP
cord-329840-f3dsu36p	115	12	*	*	NFP
cord-329840-f3dsu36p	115	13	*	*	NFP
cord-329840-f3dsu36p	115	14	*	*	NFP
cord-329840-f3dsu36p	115	15	:	:	:
cord-329840-f3dsu36p	116	1	*	*	NFP
cord-329840-f3dsu36p	116	2	*	*	NFP
cord-329840-f3dsu36p	116	3	*	*	NFP
cord-329840-f3dsu36p	116	4	*	*	NFP
cord-329840-f3dsu36p	116	5	*	*	NFP
cord-329840-f3dsu36p	116	6	CYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNS	CYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNS	NNP
cord-329840-f3dsu36p	117	1	120	120	CD
cord-329840-f3dsu36p	117	2	CoV	cov	NN
cord-329840-f3dsu36p	117	3	CYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNT	CYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNT	NNP
cord-329840-f3dsu36p	117	4	102	102	CD
cord-329840-f3dsu36p	118	1	*	*	NFP
cord-329840-f3dsu36p	118	2	*	*	NFP
cord-329840-f3dsu36p	118	3	*	*	NFP
cord-329840-f3dsu36p	118	4	*	*	NFP
cord-329840-f3dsu36p	118	5	*	*	NFP
cord-329840-f3dsu36p	118	6	*	*	NFP
cord-329840-f3dsu36p	118	7	*	*	NFP
cord-329840-f3dsu36p	118	8	*	*	NFP
cord-329840-f3dsu36p	118	9	*	*	NFP
cord-329840-f3dsu36p	118	10	*	*	NFP
cord-329840-f3dsu36p	118	11	*	*	NFP
cord-329840-f3dsu36p	118	12	*	*	NFP
cord-329840-f3dsu36p	118	13	*	*	NFP
cord-329840-f3dsu36p	118	14	:	:	:
cord-329840-f3dsu36p	119	1	*	*	NFP
cord-329840-f3dsu36p	119	2	*	*	NFP
cord-329840-f3dsu36p	119	3	*	*	NFP
cord-329840-f3dsu36p	119	4	*	*	NFP
cord-329840-f3dsu36p	119	5	*	*	NFP
cord-329840-f3dsu36p	119	6	*	*	NFP
cord-329840-f3dsu36p	119	7	*	*	NFP
cord-329840-f3dsu36p	119	8	*	*	NFP
cord-329840-f3dsu36p	119	9	:	:	:
cord-329840-f3dsu36p	119	10	:	:	:
cord-329840-f3dsu36p	120	1	*	*	NFP
cord-329840-f3dsu36p	120	2	*	*	NFP
cord-329840-f3dsu36p	120	3	:	:	:
cord-329840-f3dsu36p	121	1	*	*	NFP
cord-329840-f3dsu36p	121	2	*	*	NFP
cord-329840-f3dsu36p	121	3	*	*	NFP
cord-329840-f3dsu36p	121	4	*	*	NFP
cord-329840-f3dsu36p	121	5	*	*	NFP
cord-329840-f3dsu36p	121	6	*	*	NFP
cord-329840-f3dsu36p	121	7	*	*	NFP
cord-329840-f3dsu36p	121	8	*	*	NFP
cord-329840-f3dsu36p	121	9	*	*	NFP
cord-329840-f3dsu36p	121	10	*	*	NFP
cord-329840-f3dsu36p	121	11	*	*	NFP
cord-329840-f3dsu36p	121	12	*	*	NFP
cord-329840-f3dsu36p	121	13	*	*	NFP
cord-329840-f3dsu36p	121	14	*	*	NFP
cord-329840-f3dsu36p	121	15	*	*	NFP
cord-329840-f3dsu36p	121	16	*	*	NFP
cord-329840-f3dsu36p	121	17	*	*	NFP
cord-329840-f3dsu36p	121	18	*	*	NFP
cord-329840-f3dsu36p	121	19	*	*	NFP
cord-329840-f3dsu36p	121	20	*	*	NFP
cord-329840-f3dsu36p	121	21	*	*	NFP
cord-329840-f3dsu36p	121	22	*	*	NFP
cord-329840-f3dsu36p	121	23	*	*	NFP
cord-329840-f3dsu36p	121	24	*	*	NFP
cord-329840-f3dsu36p	121	25	*	*	NFP
cord-329840-f3dsu36p	121	26	:	:	:
cord-329840-f3dsu36p	121	27	*	*	NFP
cord-329840-f3dsu36p	122	1	*	*	NFP
cord-329840-f3dsu36p	122	2	*	*	NFP
cord-329840-f3dsu36p	122	3	:	:	:
cord-329840-f3dsu36p	122	4	The	the	DT
cord-329840-f3dsu36p	122	5	medium	medium	JJ
cord-329840-f3dsu36p	122	6	-	-	HYPH
cord-329840-f3dsu36p	122	7	scale	scale	NN
cord-329840-f3dsu36p	122	8	fluctuations	fluctuation	NNS
cord-329840-f3dsu36p	122	9	are	be	VBP
cord-329840-f3dsu36p	122	10	shown	show	VBN
cord-329840-f3dsu36p	122	11	in	in	IN
cord-329840-f3dsu36p	122	12	green	green	JJ
cord-329840-f3dsu36p	122	13	.	.	.
cord-329840-f3dsu36p	123	1	Coronavirus	Coronavirus	NNP
cord-329840-f3dsu36p	123	2	envelope	envelope	NN
cord-329840-f3dsu36p	123	3	protein	protein	NN
cord-329840-f3dsu36p	123	4	:	:	:
cord-329840-f3dsu36p	123	5	current	current	JJ
cord-329840-f3dsu36p	123	6	knowledge	knowledge	NN
cord-329840-f3dsu36p	123	7	Coronaviruses	Coronaviruses	NNPS
cord-329840-f3dsu36p	123	8	:	:	:
cord-329840-f3dsu36p	123	9	an	an	DT
cord-329840-f3dsu36p	123	10	overview	overview	NN
cord-329840-f3dsu36p	123	11	of	of	IN
cord-329840-f3dsu36p	123	12	their	-PRON-	PRP$
cord-329840-f3dsu36p	123	13	replication	replication	NN
cord-329840-f3dsu36p	123	14	and	and	CC
cord-329840-f3dsu36p	123	15	pathogenesis	pathogenesis	NN
cord-329840-f3dsu36p	123	16	Structure	Structure	NNP
cord-329840-f3dsu36p	123	17	analysis	analysis	NN
cord-329840-f3dsu36p	123	18	of	of	IN
cord-329840-f3dsu36p	123	19	the	the	DT
cord-329840-f3dsu36p	123	20	receptor	receptor	NN
cord-329840-f3dsu36p	123	21	binding	binding	NN
cord-329840-f3dsu36p	123	22	of	of	IN
cord-329840-f3dsu36p	123	23	2019-nCoV	2019-ncov	CD
cord-329840-f3dsu36p	123	24	High	high	JJ
cord-329840-f3dsu36p	123	25	expression	expression	NN
cord-329840-f3dsu36p	123	26	of	of	IN
cord-329840-f3dsu36p	123	27	ACE2	ACE2	NNP
cord-329840-f3dsu36p	123	28	receptor	receptor	NN
cord-329840-f3dsu36p	123	29	of	of	IN
cord-329840-f3dsu36p	123	30	2019-nCoV	2019-ncov	CD
cord-329840-f3dsu36p	123	31	on	on	IN
cord-329840-f3dsu36p	123	32	the	the	DT
cord-329840-f3dsu36p	123	33	epithelial	epithelial	JJ
cord-329840-f3dsu36p	123	34	cells	cell	NNS
cord-329840-f3dsu36p	123	35	of	of	IN
cord-329840-f3dsu36p	123	36	oral	oral	JJ
cord-329840-f3dsu36p	123	37	mucosa	mucosa	JJ
cord-329840-f3dsu36p	123	38	Inhibition	inhibition	NN
cord-329840-f3dsu36p	123	39	of	of	IN
cord-329840-f3dsu36p	123	40	human	human	JJ
cord-329840-f3dsu36p	123	41	immunodeficiency	immunodeficiency	NN
cord-329840-f3dsu36p	123	42	virus	virus	NN
cord-329840-f3dsu36p	123	43	infection	infection	NN
cord-329840-f3dsu36p	123	44	by	by	IN
cord-329840-f3dsu36p	123	45	agents	agent	NNS
cord-329840-f3dsu36p	123	46	that	that	WDT
cord-329840-f3dsu36p	123	47	interfere	interfere	VBP
cord-329840-f3dsu36p	123	48	with	with	IN
cord-329840-f3dsu36p	123	49	thiol	thiol	NN
cord-329840-f3dsu36p	123	50	-	-	HYPH
cord-329840-f3dsu36p	123	51	disulfide	disulfide	NN
cord-329840-f3dsu36p	123	52	interchange	interchange	NN
cord-329840-f3dsu36p	123	53	upon	upon	IN
cord-329840-f3dsu36p	123	54	virus	virus	NN
cord-329840-f3dsu36p	123	55	-	-	HYPH
cord-329840-f3dsu36p	123	56	receptor	receptor	NN
cord-329840-f3dsu36p	123	57	interaction	interaction	NN
cord-329840-f3dsu36p	123	58	Inhibitors	Inhibitors	NNP
cord-329840-f3dsu36p	123	59	of	of	IN
cord-329840-f3dsu36p	123	60	protein	protein	NN
cord-329840-f3dsu36p	123	61	-	-	HYPH
cord-329840-f3dsu36p	123	62	disulfide	disulfide	NN
cord-329840-f3dsu36p	123	63	isomerase	isomerase	NN
cord-329840-f3dsu36p	123	64	prevent	prevent	VBP
cord-329840-f3dsu36p	123	65	cleavage	cleavage	NN
cord-329840-f3dsu36p	123	66	of	of	IN
cord-329840-f3dsu36p	123	67	disulfide	disulfide	JJ
cord-329840-f3dsu36p	123	68	bonds	bond	NNS
cord-329840-f3dsu36p	123	69	in	in	IN
cord-329840-f3dsu36p	123	70	receptor	receptor	NN
cord-329840-f3dsu36p	123	71	-	-	HYPH
cord-329840-f3dsu36p	123	72	bound	bind	VBN
cord-329840-f3dsu36p	123	73	glycoprotein	glycoprotein	NN
cord-329840-f3dsu36p	123	74	120	120	CD
cord-329840-f3dsu36p	123	75	and	and	CC
cord-329840-f3dsu36p	123	76	prevent	prevent	VB
cord-329840-f3dsu36p	123	77	HIV-1	HIV-1	NNP
cord-329840-f3dsu36p	123	78	entry	entry	NN
cord-329840-f3dsu36p	123	79	Significant	significant	JJ
cord-329840-f3dsu36p	123	80	redox	redox	JJ
cord-329840-f3dsu36p	123	81	insensitivity	insensitivity	NN
cord-329840-f3dsu36p	123	82	of	of	IN
cord-329840-f3dsu36p	123	83	the	the	DT
cord-329840-f3dsu36p	123	84	functions	function	NNS
cord-329840-f3dsu36p	123	85	of	of	IN
cord-329840-f3dsu36p	123	86	the	the	DT
cord-329840-f3dsu36p	123	87	SARS	SARS	NNP
cord-329840-f3dsu36p	123	88	-	-	HYPH
cord-329840-f3dsu36p	123	89	CoV	CoV	NNP
cord-329840-f3dsu36p	123	90	spike	spike	NN
cord-329840-f3dsu36p	123	91	glycoprotein	glycoprotein	NN
cord-329840-f3dsu36p	123	92	:	:	:
cord-329840-f3dsu36p	124	1	comparison	comparison	NN
cord-329840-f3dsu36p	124	2	with	with	IN
cord-329840-f3dsu36p	124	3	HIV	HIV	NNP
cord-329840-f3dsu36p	124	4	envelope	envelope	NN
cord-329840-f3dsu36p	124	5	Cell	cell	NN
cord-329840-f3dsu36p	124	6	surface	surface	NN
cord-329840-f3dsu36p	124	7	protein	protein	NN
cord-329840-f3dsu36p	124	8	disulfide	disulfide	NN
cord-329840-f3dsu36p	124	9	isomerase	isomerase	NN
cord-329840-f3dsu36p	124	10	regulates	regulate	VBZ
cord-329840-f3dsu36p	124	11	natriuretic	natriuretic	JJ
cord-329840-f3dsu36p	124	12	peptide	peptide	JJ
cord-329840-f3dsu36p	124	13	generation	generation	NN
cord-329840-f3dsu36p	124	14	of	of	IN
cord-329840-f3dsu36p	124	15	cyclic	cyclic	JJ
cord-329840-f3dsu36p	124	16	guanosine	guanosine	NN
cord-329840-f3dsu36p	125	1	monophosphate	monophosphate	NN
cord-329840-f3dsu36p	126	1	The	the	DT
cord-329840-f3dsu36p	126	2	role	role	NN
cord-329840-f3dsu36p	126	3	of	of	IN
cord-329840-f3dsu36p	126	4	cellular	cellular	JJ
cord-329840-f3dsu36p	126	5	oxidoreductases	oxidoreductase	NNS
cord-329840-f3dsu36p	126	6	in	in	IN
cord-329840-f3dsu36p	126	7	viral	viral	JJ
cord-329840-f3dsu36p	126	8	entry	entry	NN
cord-329840-f3dsu36p	126	9	and	and	CC
cord-329840-f3dsu36p	126	10	virus	virus	NN
cord-329840-f3dsu36p	126	11	infectionassociated	infectionassociate	VBN
cord-329840-f3dsu36p	126	12	oxidative	oxidative	JJ
cord-329840-f3dsu36p	126	13	stress	stress	NN
cord-329840-f3dsu36p	126	14	:	:	:
cord-329840-f3dsu36p	126	15	potential	potential	JJ
cord-329840-f3dsu36p	126	16	therapeutic	therapeutic	JJ
cord-329840-f3dsu36p	126	17	applications	application	NNS
cord-329840-f3dsu36p	126	18	Implications	implication	NNS
cord-329840-f3dsu36p	126	19	of	of	IN
cord-329840-f3dsu36p	126	20	oxidative	oxidative	JJ
cord-329840-f3dsu36p	126	21	stress	stress	NN
cord-329840-f3dsu36p	126	22	on	on	IN
cord-329840-f3dsu36p	126	23	viral	viral	JJ
cord-329840-f3dsu36p	126	24	pathogenesis	pathogenesis	NN
cord-329840-f3dsu36p	126	25	Cell	cell	NN
cord-329840-f3dsu36p	126	26	entry	entry	NN
cord-329840-f3dsu36p	126	27	by	by	IN
cord-329840-f3dsu36p	126	28	enveloped	envelop	VBN
cord-329840-f3dsu36p	126	29	viruses	virus	NNS
cord-329840-f3dsu36p	126	30	:	:	:
cord-329840-f3dsu36p	126	31	redox	redox	JJ
cord-329840-f3dsu36p	126	32	considerations	consideration	NNS
cord-329840-f3dsu36p	126	33	for	for	IN
cord-329840-f3dsu36p	126	34	HIV	HIV	NNP
cord-329840-f3dsu36p	126	35	and	and	CC
cord-329840-f3dsu36p	126	36	SARS	SARS	NNP
cord-329840-f3dsu36p	126	37	-	-	HYPH
cord-329840-f3dsu36p	126	38	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	126	39	Thiol	Thiol	NNP
cord-329840-f3dsu36p	126	40	-	-	HYPH
cord-329840-f3dsu36p	126	41	Disulfide	Disulfide	NNP
cord-329840-f3dsu36p	126	42	Exchange	Exchange	NNP
cord-329840-f3dsu36p	126	43	Reactions	Reactions	NNPS
cord-329840-f3dsu36p	126	44	in	in	IN
cord-329840-f3dsu36p	126	45	the	the	DT
cord-329840-f3dsu36p	126	46	Mammalian	Mammalian	NNP
cord-329840-f3dsu36p	126	47	Extracellular	Extracellular	NNP
cord-329840-f3dsu36p	126	48	Environment	Environment	NNP
cord-329840-f3dsu36p	126	49	Structural	Structural	NNP
cord-329840-f3dsu36p	126	50	analysis	analysis	NN
cord-329840-f3dsu36p	126	51	of	of	IN
cord-329840-f3dsu36p	126	52	major	major	JJ
cord-329840-f3dsu36p	126	53	species	species	NN
cord-329840-f3dsu36p	126	54	barriers	barrier	NNS
cord-329840-f3dsu36p	126	55	between	between	IN
cord-329840-f3dsu36p	126	56	humans	human	NNS
cord-329840-f3dsu36p	126	57	and	and	CC
cord-329840-f3dsu36p	126	58	palm	palm	NN
cord-329840-f3dsu36p	126	59	civets	civet	NNS
cord-329840-f3dsu36p	126	60	for	for	IN
cord-329840-f3dsu36p	126	61	severe	severe	JJ
cord-329840-f3dsu36p	126	62	acute	acute	JJ
cord-329840-f3dsu36p	126	63	respiratory	respiratory	JJ
cord-329840-f3dsu36p	126	64	syndrome	syndrome	NN
cord-329840-f3dsu36p	126	65	coronavirus	coronavirus	NN
cord-329840-f3dsu36p	126	66	infections	infection	NNS
cord-329840-f3dsu36p	126	67	Cryo	Cryo	NNP
cord-329840-f3dsu36p	126	68	-	-	HYPH
cord-329840-f3dsu36p	126	69	EM	EM	NNP
cord-329840-f3dsu36p	126	70	structure	structure	NN
cord-329840-f3dsu36p	126	71	of	of	IN
cord-329840-f3dsu36p	126	72	the	the	DT
cord-329840-f3dsu36p	126	73	2019-nCoV	2019-ncov	CD
cord-329840-f3dsu36p	126	74	spike	spike	NN
cord-329840-f3dsu36p	126	75	in	in	IN
cord-329840-f3dsu36p	126	76	the	the	DT
cord-329840-f3dsu36p	126	77	prefusion	prefusion	NN
cord-329840-f3dsu36p	126	78	conformation	conformation	NN
cord-329840-f3dsu36p	126	79	Structural	Structural	NNP
cord-329840-f3dsu36p	126	80	and	and	CC
cord-329840-f3dsu36p	126	81	Functional	Functional	NNP
cord-329840-f3dsu36p	126	82	Basis	Basis	NNP
cord-329840-f3dsu36p	126	83	of	of	IN
cord-329840-f3dsu36p	126	84	SARS	SARS	NNP
cord-329840-f3dsu36p	126	85	-	-	HYPH
cord-329840-f3dsu36p	126	86	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	126	87	Entry	Entry	NNP
cord-329840-f3dsu36p	126	88	by	by	IN
cord-329840-f3dsu36p	126	89	Using	use	VBG
cord-329840-f3dsu36p	126	90	Human	Human	NNP
cord-329840-f3dsu36p	126	91	ACE2	ACE2	NNP
cord-329840-f3dsu36p	126	92	Structural	structural	JJ
cord-329840-f3dsu36p	126	93	basis	basis	NN
cord-329840-f3dsu36p	126	94	for	for	IN
cord-329840-f3dsu36p	126	95	the	the	DT
cord-329840-f3dsu36p	126	96	recognition	recognition	NN
cord-329840-f3dsu36p	126	97	of	of	IN
cord-329840-f3dsu36p	126	98	SARS	SARS	NNP
cord-329840-f3dsu36p	126	99	-	-	HYPH
cord-329840-f3dsu36p	126	100	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	126	101	by	by	IN
cord-329840-f3dsu36p	126	102	full	full	JJ
cord-329840-f3dsu36p	126	103	-	-	HYPH
cord-329840-f3dsu36p	126	104	length	length	NN
cord-329840-f3dsu36p	126	105	human	human	JJ
cord-329840-f3dsu36p	126	106	ACE2	ACE2	NNP
cord-329840-f3dsu36p	126	107	Crowder	Crowder	NNP
cord-329840-f3dsu36p	126	108	-	-	HYPH
cord-329840-f3dsu36p	126	109	Induced	Induced	NNP
cord-329840-f3dsu36p	126	110	Conformational	Conformational	NNP
cord-329840-f3dsu36p	126	111	Ensemble	Ensemble	NNP
cord-329840-f3dsu36p	126	112	Shift	Shift	NNP
cord-329840-f3dsu36p	126	113	in	in	IN
cord-329840-f3dsu36p	126	114	Escherichia	Escherichia	NNP
cord-329840-f3dsu36p	126	115	coli	coli	NNS
cord-329840-f3dsu36p	127	1	Prolyl	Prolyl	NNP
cord-329840-f3dsu36p	127	2	-	-	HYPH
cord-329840-f3dsu36p	127	3	tRNA	trna	NN
cord-329840-f3dsu36p	127	4	Synthetase	Synthetase	NNP
cord-329840-f3dsu36p	128	1	From	from	IN
cord-329840-f3dsu36p	128	2	structure	structure	NN
cord-329840-f3dsu36p	128	3	to	to	IN
cord-329840-f3dsu36p	128	4	redox	redox	NN
cord-329840-f3dsu36p	128	5	:	:	:
cord-329840-f3dsu36p	128	6	The	the	DT
cord-329840-f3dsu36p	128	7	diverse	diverse	JJ
cord-329840-f3dsu36p	128	8	functional	functional	JJ
cord-329840-f3dsu36p	128	9	roles	role	NNS
cord-329840-f3dsu36p	128	10	of	of	IN
cord-329840-f3dsu36p	128	11	disulfides	disulfide	NNS
cord-329840-f3dsu36p	128	12	and	and	CC
cord-329840-f3dsu36p	128	13	implications	implication	NNS
cord-329840-f3dsu36p	128	14	in	in	IN
cord-329840-f3dsu36p	128	15	disease	disease	NN
cord-329840-f3dsu36p	128	16	Plasma	Plasma	NNP
cord-329840-f3dsu36p	128	17	membrane	membrane	NN
cord-329840-f3dsu36p	128	18	glutathione	glutathione	NN
cord-329840-f3dsu36p	128	19	transporters	transporter	NNS
cord-329840-f3dsu36p	128	20	and	and	CC
cord-329840-f3dsu36p	128	21	their	-PRON-	PRP$
cord-329840-f3dsu36p	128	22	roles	role	NNS
cord-329840-f3dsu36p	128	23	in	in	IN
cord-329840-f3dsu36p	128	24	cell	cell	NN
cord-329840-f3dsu36p	128	25	physiology	physiology	NN
cord-329840-f3dsu36p	128	26	and	and	CC
cord-329840-f3dsu36p	128	27	pathophysiology	pathophysiology	NN
cord-329840-f3dsu36p	128	28	ACE2-mediated	ace2-mediated	JJ
cord-329840-f3dsu36p	128	29	reduction	reduction	NN
cord-329840-f3dsu36p	128	30	of	of	IN
cord-329840-f3dsu36p	128	31	oxidative	oxidative	JJ
cord-329840-f3dsu36p	128	32	stress	stress	NN
cord-329840-f3dsu36p	128	33	in	in	IN
cord-329840-f3dsu36p	128	34	the	the	DT
cord-329840-f3dsu36p	128	35	central	central	JJ
cord-329840-f3dsu36p	128	36	nervous	nervous	JJ
cord-329840-f3dsu36p	128	37	system	system	NN
cord-329840-f3dsu36p	128	38	is	be	VBZ
cord-329840-f3dsu36p	128	39	associated	associate	VBN
cord-329840-f3dsu36p	128	40	with	with	IN
cord-329840-f3dsu36p	128	41	improvement	improvement	NN
cord-329840-f3dsu36p	128	42	of	of	IN
cord-329840-f3dsu36p	128	43	autonomic	autonomic	JJ
cord-329840-f3dsu36p	128	44	function	function	NN
cord-329840-f3dsu36p	128	45	VMD	VMD	NNP
cord-329840-f3dsu36p	128	46	:	:	:
cord-329840-f3dsu36p	128	47	visual	visual	JJ
cord-329840-f3dsu36p	128	48	molecular	molecular	JJ
cord-329840-f3dsu36p	128	49	dynamics	dynamic	NNS
cord-329840-f3dsu36p	128	50	CHARMM	CHARMM	NNP
cord-329840-f3dsu36p	128	51	Additive	Additive	NNP
cord-329840-f3dsu36p	128	52	All	All	NNP
cord-329840-f3dsu36p	128	53	-	-	HYPH
cord-329840-f3dsu36p	128	54	Atom	Atom	NNP
cord-329840-f3dsu36p	128	55	Force	Force	NNP
cord-329840-f3dsu36p	128	56	Field	Field	NNP
cord-329840-f3dsu36p	128	57	for	for	IN
cord-329840-f3dsu36p	128	58	Glycosidic	Glycosidic	NNP
cord-329840-f3dsu36p	128	59	Linkages	Linkages	NNP
cord-329840-f3dsu36p	128	60	between	between	IN
cord-329840-f3dsu36p	128	61	Hexopyranoses	Hexopyranoses	NNPS
cord-329840-f3dsu36p	128	62	CHARMM	CHARMM	NNP
cord-329840-f3dsu36p	128	63	additive	additive	NN
cord-329840-f3dsu36p	128	64	all	all	DT
cord-329840-f3dsu36p	128	65	-	-	HYPH
cord-329840-f3dsu36p	128	66	atom	atom	NN
cord-329840-f3dsu36p	128	67	force	force	NN
cord-329840-f3dsu36p	128	68	field	field	NN
cord-329840-f3dsu36p	128	69	for	for	IN
cord-329840-f3dsu36p	128	70	glycosidic	glycosidic	JJ
cord-329840-f3dsu36p	128	71	linkages	linkage	NNS
cord-329840-f3dsu36p	128	72	in	in	IN
cord-329840-f3dsu36p	128	73	carbohydrates	carbohydrate	NNS
cord-329840-f3dsu36p	128	74	involving	involve	VBG
cord-329840-f3dsu36p	128	75	furanoses	furanose	NNS
cord-329840-f3dsu36p	128	76	CHARMM	CHARMM	NNP
cord-329840-f3dsu36p	128	77	additive	additive	NN
cord-329840-f3dsu36p	129	1	all	all	DT
cord-329840-f3dsu36p	129	2	-	-	HYPH
cord-329840-f3dsu36p	129	3	atom	atom	NN
cord-329840-f3dsu36p	129	4	force	force	NN
cord-329840-f3dsu36p	129	5	field	field	NN
cord-329840-f3dsu36p	129	6	for	for	IN
cord-329840-f3dsu36p	129	7	carbohydrate	carbohydrate	NN
cord-329840-f3dsu36p	129	8	derivatives	derivative	NNS
cord-329840-f3dsu36p	129	9	and	and	CC
cord-329840-f3dsu36p	129	10	its	-PRON-	PRP$
cord-329840-f3dsu36p	129	11	utility	utility	NN
cord-329840-f3dsu36p	129	12	in	in	IN
cord-329840-f3dsu36p	129	13	polysaccharide	polysaccharide	NN
cord-329840-f3dsu36p	129	14	and	and	CC
cord-329840-f3dsu36p	129	15	carbohydrate	carbohydrate	NN
cord-329840-f3dsu36p	129	16	-	-	HYPH
cord-329840-f3dsu36p	129	17	protein	protein	NN
cord-329840-f3dsu36p	129	18	modeling	modeling	NN
cord-329840-f3dsu36p	129	19	Optimization	optimization	NN
cord-329840-f3dsu36p	129	20	of	of	IN
cord-329840-f3dsu36p	129	21	the	the	DT
cord-329840-f3dsu36p	129	22	additive	additive	NN
cord-329840-f3dsu36p	129	23	CHARMM	CHARMM	NNP
cord-329840-f3dsu36p	130	1	all	all	DT
cord-329840-f3dsu36p	130	2	-	-	HYPH
cord-329840-f3dsu36p	130	3	atom	atom	NN
cord-329840-f3dsu36p	130	4	protein	protein	NN
cord-329840-f3dsu36p	130	5	force	force	NN
cord-329840-f3dsu36p	130	6	field	field	NN
cord-329840-f3dsu36p	130	7	targeting	target	VBG
cord-329840-f3dsu36p	130	8	improved	improved	JJ
cord-329840-f3dsu36p	130	9	sampling	sampling	NN
cord-329840-f3dsu36p	130	10	of	of	IN
cord-329840-f3dsu36p	130	11	the	the	DT
cord-329840-f3dsu36p	130	12	backbone	backbone	NN
cord-329840-f3dsu36p	130	13	(	(	-LRB-
cord-329840-f3dsu36p	130	14	2	2	LS
cord-329840-f3dsu36p	130	15	)	)	-RRB-
cord-329840-f3dsu36p	130	16	dihedral	dihedral	JJ
cord-329840-f3dsu36p	130	17	angles	angle	NNS
cord-329840-f3dsu36p	131	1	CHARMM	CHARMM	NNP
cord-329840-f3dsu36p	131	2	Additive	Additive	NNP
cord-329840-f3dsu36p	131	3	All	All	NNP
cord-329840-f3dsu36p	131	4	-	-	HYPH
cord-329840-f3dsu36p	131	5	Atom	Atom	NNP
cord-329840-f3dsu36p	131	6	Force	Force	NNP
cord-329840-f3dsu36p	131	7	Field	Field	NNP
cord-329840-f3dsu36p	131	8	for	for	IN
cord-329840-f3dsu36p	131	9	Phosphate	Phosphate	NNP
cord-329840-f3dsu36p	131	10	and	and	CC
cord-329840-f3dsu36p	131	11	Sulfate	Sulfate	NNP
cord-329840-f3dsu36p	131	12	Linked	link	VBN
cord-329840-f3dsu36p	131	13	to	to	IN
cord-329840-f3dsu36p	131	14	Carbohydrates	carbohydrate	NNS
cord-329840-f3dsu36p	132	1	A	a	DT
cord-329840-f3dsu36p	132	2	smooth	smooth	JJ
cord-329840-f3dsu36p	132	3	particle	particle	NN
cord-329840-f3dsu36p	132	4	mesh	mesh	NN
cord-329840-f3dsu36p	132	5	Ewald	Ewald	NNP
cord-329840-f3dsu36p	132	6	method	method	NN
cord-329840-f3dsu36p	132	7	Improvements	improvement	NNS
cord-329840-f3dsu36p	132	8	to	to	IN
cord-329840-f3dsu36p	132	9	the	the	DT
cord-329840-f3dsu36p	132	10	APBS	APBS	NNP
cord-329840-f3dsu36p	132	11	biomolecular	biomolecular	JJ
cord-329840-f3dsu36p	132	12	solvation	solvation	NN
cord-329840-f3dsu36p	132	13	software	software	NN
cord-329840-f3dsu36p	132	14	suite	suite	NN
cord-329840-f3dsu36p	132	15	PDB2PQR	PDB2PQR	NNP
cord-329840-f3dsu36p	132	16	:	:	:
cord-329840-f3dsu36p	133	1	expanding	expand	VBG
cord-329840-f3dsu36p	133	2	and	and	CC
cord-329840-f3dsu36p	133	3	upgrading	upgrade	VBG
cord-329840-f3dsu36p	133	4	automated	automate	VBN
cord-329840-f3dsu36p	133	5	preparation	preparation	NN
cord-329840-f3dsu36p	133	6	of	of	IN
cord-329840-f3dsu36p	133	7	biomolecular	biomolecular	JJ
cord-329840-f3dsu36p	133	8	structures	structure	NNS
cord-329840-f3dsu36p	133	9	for	for	IN
cord-329840-f3dsu36p	133	10	molecular	molecular	JJ
cord-329840-f3dsu36p	133	11	simulations	simulation	NNS
cord-329840-f3dsu36p	134	1	Multiple	multiple	JJ
cord-329840-f3dsu36p	134	2	pathways	pathway	NNS
cord-329840-f3dsu36p	134	3	promote	promote	VBP
cord-329840-f3dsu36p	134	4	dynamical	dynamical	JJ
cord-329840-f3dsu36p	134	5	coupling	coupling	NN
cord-329840-f3dsu36p	134	6	between	between	IN
cord-329840-f3dsu36p	134	7	catalytic	catalytic	JJ
cord-329840-f3dsu36p	134	8	domains	domain	NNS
cord-329840-f3dsu36p	134	9	in	in	IN
cord-329840-f3dsu36p	134	10	Escherichia	Escherichia	NNP
cord-329840-f3dsu36p	134	11	coli	coli	NNS
cord-329840-f3dsu36p	134	12	prolyl	prolyl	NNP
cord-329840-f3dsu36p	134	13	-	-	HYPH
cord-329840-f3dsu36p	134	14	tRNA	tRNA	NNP
cord-329840-f3dsu36p	134	15	synthetase	synthetase	NNP
cord-329840-f3dsu36p	134	16	Computer	Computer	NNP
cord-329840-f3dsu36p	134	17	"	"	''
cord-329840-f3dsu36p	134	18	"	"	``
cord-329840-f3dsu36p	134	19	experiments	experiment	NNS
cord-329840-f3dsu36p	134	20	"	"	''
cord-329840-f3dsu36p	134	21	on	on	IN
cord-329840-f3dsu36p	134	22	classic	classic	JJ
cord-329840-f3dsu36p	134	23	fluids	fluid	NNS
cord-329840-f3dsu36p	134	24	.	.	.
cord-329840-f3dsu36p	135	1	I.	I.	NNP
cord-329840-f3dsu36p	135	2	Thermodynamical	Thermodynamical	NNP
cord-329840-f3dsu36p	135	3	properties	property	NNS
cord-329840-f3dsu36p	135	4	of	of	IN
cord-329840-f3dsu36p	135	5	Lennard	Lennard	NNP
cord-329840-f3dsu36p	135	6	-	-	HYPH
cord-329840-f3dsu36p	135	7	Jones	Jones	NNP
cord-329840-f3dsu36p	135	8	molecules	molecule	NNS
cord-329840-f3dsu36p	135	9	Scalable	scalable	JJ
cord-329840-f3dsu36p	135	10	molecular	molecular	JJ
cord-329840-f3dsu36p	135	11	dynamics	dynamic	NNS
cord-329840-f3dsu36p	135	12	with	with	IN
cord-329840-f3dsu36p	135	13	NAMD	NAMD	NNP
cord-329840-f3dsu36p	136	1	A	a	DT
cord-329840-f3dsu36p	136	2	treecode	treecode	NN
cord-329840-f3dsu36p	136	3	-	-	HYPH
cord-329840-f3dsu36p	136	4	accelerated	accelerate	VBN
cord-329840-f3dsu36p	136	5	boundary	boundary	JJ
cord-329840-f3dsu36p	136	6	integral	integral	JJ
cord-329840-f3dsu36p	136	7	Poisson	Poisson	NNP
cord-329840-f3dsu36p	136	8	-	-	HYPH
cord-329840-f3dsu36p	136	9	Boltzmann	Boltzmann	NNP
cord-329840-f3dsu36p	136	10	solver	solver	NN
cord-329840-f3dsu36p	136	11	for	for	IN
cord-329840-f3dsu36p	136	12	electrostatics	electrostatic	NNS
cord-329840-f3dsu36p	136	13	of	of	IN
cord-329840-f3dsu36p	136	14	solvated	solvate	VBN
cord-329840-f3dsu36p	136	15	biomolecules	biomolecule	NNS
cord-329840-f3dsu36p	136	16	Structure	Structure	NNP
cord-329840-f3dsu36p	136	17	of	of	IN
cord-329840-f3dsu36p	136	18	the	the	DT
cord-329840-f3dsu36p	136	19	SARS	SARS	NNP
cord-329840-f3dsu36p	136	20	-	-	HYPH
cord-329840-f3dsu36p	136	21	CoV-2	CoV-2	NNP
cord-329840-f3dsu36p	136	22	spike	spike	NN
cord-329840-f3dsu36p	136	23	receptor	receptor	NN
cord-329840-f3dsu36p	136	24	-	-	HYPH
cord-329840-f3dsu36p	136	25	binding	bind	VBG
cord-329840-f3dsu36p	136	26	domain	domain	NN
cord-329840-f3dsu36p	136	27	bound	bind	VBN
cord-329840-f3dsu36p	136	28	to	to	IN
cord-329840-f3dsu36p	136	29	the	the	DT
cord-329840-f3dsu36p	136	30	ACE2	ACE2	NNP
cord-329840-f3dsu36p	136	31	receptor	receptor	NN
cord-329840-f3dsu36p	137	1	The	the	DT
cord-329840-f3dsu36p	137	2	EMBL	EMBL	NNP
cord-329840-f3dsu36p	137	3	-	-	HYPH
cord-329840-f3dsu36p	137	4	EBI	ebi	NN
cord-329840-f3dsu36p	137	5	search	search	NN
cord-329840-f3dsu36p	137	6	and	and	CC
cord-329840-f3dsu36p	137	7	sequence	sequence	NN
cord-329840-f3dsu36p	137	8	analysis	analysis	NN
cord-329840-f3dsu36p	137	9	tools	tool	NNS
cord-329840-f3dsu36p	137	10	APIs	api	NNS
cord-329840-f3dsu36p	137	11	in	in	IN
cord-329840-f3dsu36p	137	12	2019	2019	CD
cord-329840-f3dsu36p	138	1	We	-PRON-	PRP
cord-329840-f3dsu36p	138	2	acknowledge	acknowledge	VBP
cord-329840-f3dsu36p	138	3	computational	computational	JJ
cord-329840-f3dsu36p	138	4	support	support	NN
cord-329840-f3dsu36p	138	5	from	from	IN
cord-329840-f3dsu36p	138	6	the	the	DT
cord-329840-f3dsu36p	138	7	Blugold	Blugold	NNP
cord-329840-f3dsu36p	138	8	Super	Super	NNP
cord-329840-f3dsu36p	138	9	Computing	Computing	NNP
cord-329840-f3dsu36p	138	10	Cluster	Cluster	NNP
cord-329840-f3dsu36p	138	11	(	(	-LRB-
cord-329840-f3dsu36p	138	12	BGSC	BGSC	NNP
cord-329840-f3dsu36p	138	13	)	)	-RRB-
cord-329840-f3dsu36p	138	14	of	of	IN
cord-329840-f3dsu36p	138	15	University	University	NNP
cord-329840-f3dsu36p	138	16	of	of	IN
cord-329840-f3dsu36p	138	17	Wisconsin	Wisconsin	NNP
cord-329840-f3dsu36p	138	18	-	-	HYPH
cord-329840-f3dsu36p	138	19	Eau	Eau	NNP
cord-329840-f3dsu36p	138	20	Claire	Claire	NNP
cord-329840-f3dsu36p	138	21	.	.	.
cord-329840-f3dsu36p	138	22	 	 	_SP
cord-329840-f3dsu36p	139	1	Figure	figure	NN
cord-329840-f3dsu36p	139	2	.	.	.
cord-329840-f3dsu36p	140	1	2	2	LS
cord-329840-f3dsu36p	140	2	.	.	.
cord-329840-f3dsu36p	141	1	Structures	structure	NNS
cord-329840-f3dsu36p	141	2	of	of	IN
cord-329840-f3dsu36p	141	3	protein	protein	NN
cord-329840-f3dsu36p	141	4	complexes	complex	NNS
cord-329840-f3dsu36p	141	5	of	of	IN
cord-329840-f3dsu36p	141	6	a	a	DT
cord-329840-f3dsu36p	141	7	)	)	-RRB-
cord-329840-f3dsu36p	141	8	SARS	SARS	NNP
cord-329840-f3dsu36p	141	9	-	-	HYPH
cord-329840-f3dsu36p	141	10	CoV⋅⋅⋅ACE2	CoV⋅⋅⋅ACE2	NNP
cord-329840-f3dsu36p	141	11	and	and	CC
cord-329840-f3dsu36p	141	12	b	b	LS
cord-329840-f3dsu36p	141	13	)	)	-RRB-
cord-329840-f3dsu36p	141	14	SARS	SARS	NNP
cord-329840-f3dsu36p	141	15	-	-	HYPH
cord-329840-f3dsu36p	141	16	CoV-2⋅⋅⋅ACE2	CoV-2⋅⋅⋅ACE2	NNP
cord-329840-f3dsu36p	141	17	.	.	.
cord-329840-f3dsu36p	142	1	All	all	PDT
cord-329840-f3dsu36p	142	2	the	the	DT
cord-329840-f3dsu36p	142	3	disulfide	disulfide	JJ
cord-329840-f3dsu36p	142	4	bridges	bridge	NNS
cord-329840-f3dsu36p	142	5	between	between	IN
cord-329840-f3dsu36p	142	6	cysteine	cysteine	NN
cord-329840-f3dsu36p	142	7	residues	residue	NNS
cord-329840-f3dsu36p	142	8	are	be	VBP
cord-329840-f3dsu36p	142	9	shown	show	VBN
cord-329840-f3dsu36p	142	10	in	in	IN
cord-329840-f3dsu36p	142	11	green	green	JJ
cord-329840-f3dsu36p	142	12	vdW	vdw	JJ
cord-329840-f3dsu36p	142	13	spheres	sphere	NNS
cord-329840-f3dsu36p	142	14	and	and	CC
cord-329840-f3dsu36p	142	15	thiol	thiol	NN
cord-329840-f3dsu36p	142	16	groups	group	NNS
cord-329840-f3dsu36p	142	17	in	in	IN
cord-329840-f3dsu36p	142	18	cyan	cyan	JJ
cord-329840-f3dsu36p	142	19	licorice	licorice	NNS
cord-329840-f3dsu36p	142	20	.	.	.
cord-329840-f3dsu36p	142	21	 	 	_SP