id sid tid token lemma pos cord-326666-melz5fq4 1 1 key key NN cord-326666-melz5fq4 1 2 : : : cord-326666-melz5fq4 2 1 cord-326666-melz5fq4 cord-326666-melz5fq4 VBN cord-326666-melz5fq4 2 2 authors author NNS cord-326666-melz5fq4 2 3 : : : cord-326666-melz5fq4 2 4 Sun Sun NNP cord-326666-melz5fq4 2 5 , , , cord-326666-melz5fq4 2 6 Weitao Weitao NNP cord-326666-melz5fq4 2 7 title title NN cord-326666-melz5fq4 2 8 : : : cord-326666-melz5fq4 3 1 The the DT cord-326666-melz5fq4 3 2 discovery discovery NN cord-326666-melz5fq4 3 3 of of IN cord-326666-melz5fq4 3 4 gene gene NN cord-326666-melz5fq4 3 5 mutations mutation NNS cord-326666-melz5fq4 3 6 making make VBG cord-326666-melz5fq4 3 7 SARS SARS NNP cord-326666-melz5fq4 3 8 - - HYPH cord-326666-melz5fq4 3 9 CoV-2 CoV-2 NNP cord-326666-melz5fq4 3 10 well well RB cord-326666-melz5fq4 3 11 adapted adapt VBN cord-326666-melz5fq4 3 12 for for IN cord-326666-melz5fq4 3 13 humans human NNS cord-326666-melz5fq4 3 14 : : : cord-326666-melz5fq4 3 15 host host NN cord-326666-melz5fq4 3 16 - - HYPH cord-326666-melz5fq4 3 17 genome genome NN cord-326666-melz5fq4 3 18 similarity similarity NN cord-326666-melz5fq4 3 19 analysis analysis NN cord-326666-melz5fq4 3 20 of of IN cord-326666-melz5fq4 3 21 2594 2594 CD cord-326666-melz5fq4 3 22 genomes genome NNS cord-326666-melz5fq4 3 23 from from IN cord-326666-melz5fq4 3 24 China China NNP cord-326666-melz5fq4 3 25 , , , cord-326666-melz5fq4 3 26 the the DT cord-326666-melz5fq4 3 27 USA USA NNP cord-326666-melz5fq4 3 28 and and CC cord-326666-melz5fq4 3 29 Europe Europe NNP cord-326666-melz5fq4 3 30 date date NN cord-326666-melz5fq4 3 31 : : : cord-326666-melz5fq4 3 32 2020 2020 CD cord-326666-melz5fq4 3 33 - - HYPH cord-326666-melz5fq4 3 34 09 09 CD cord-326666-melz5fq4 3 35 - - HYPH cord-326666-melz5fq4 3 36 03 03 CD cord-326666-melz5fq4 3 37 journal journal NN cord-326666-melz5fq4 3 38 : : : cord-326666-melz5fq4 4 1 bioRxiv biorxiv IN cord-326666-melz5fq4 4 2 DOI DOI NNP cord-326666-melz5fq4 4 3 : : : cord-326666-melz5fq4 5 1 10.1101/2020.09.03.280727 10.1101/2020.09.03.280727 CD cord-326666-melz5fq4 6 1 sha sha NNP cord-326666-melz5fq4 6 2 : : : cord-326666-melz5fq4 7 1 e58fd190d343f73e8f254a308b4a1f4ce78f30b5 e58fd190d343f73e8f254a308b4a1f4ce78f30b5 UH cord-326666-melz5fq4 7 2 doc_id doc_id CD cord-326666-melz5fq4 7 3 : : : cord-326666-melz5fq4 7 4 326666 326666 CD cord-326666-melz5fq4 7 5 cord_uid cord_uid NNS cord-326666-melz5fq4 7 6 : : : cord-326666-melz5fq4 8 1 melz5fq4 melz5fq4 NFP cord-326666-melz5fq4 9 1 Severe severe JJ cord-326666-melz5fq4 9 2 acute acute JJ cord-326666-melz5fq4 9 3 respiratory respiratory JJ cord-326666-melz5fq4 9 4 syndrome syndrome NN cord-326666-melz5fq4 9 5 coronavirus coronavirus NN cord-326666-melz5fq4 9 6 2 2 CD cord-326666-melz5fq4 10 1 ( ( -LRB- cord-326666-melz5fq4 10 2 SARS SARS NNP cord-326666-melz5fq4 10 3 - - HYPH cord-326666-melz5fq4 10 4 CoV-2 CoV-2 NNP cord-326666-melz5fq4 10 5 ) ) -RRB- cord-326666-melz5fq4 10 6 , , , cord-326666-melz5fq4 10 7 a a DT cord-326666-melz5fq4 10 8 positive positive JJ cord-326666-melz5fq4 10 9 - - HYPH cord-326666-melz5fq4 10 10 sense sense NN cord-326666-melz5fq4 10 11 single single JJ cord-326666-melz5fq4 10 12 - - HYPH cord-326666-melz5fq4 10 13 stranded strand VBN cord-326666-melz5fq4 10 14 virus virus NN cord-326666-melz5fq4 10 15 approximately approximately RB cord-326666-melz5fq4 10 16 30 30 CD cord-326666-melz5fq4 10 17 kb kb NNS cord-326666-melz5fq4 10 18 in in IN cord-326666-melz5fq4 10 19 length length NN cord-326666-melz5fq4 10 20 , , , cord-326666-melz5fq4 10 21 causes cause VBZ cord-326666-melz5fq4 10 22 the the DT cord-326666-melz5fq4 10 23 ongoing ongoing JJ cord-326666-melz5fq4 10 24 novel novel NN cord-326666-melz5fq4 10 25 coronavirus coronavirus NN cord-326666-melz5fq4 10 26 disease-2019 disease-2019 NNP cord-326666-melz5fq4 10 27 ( ( -LRB- cord-326666-melz5fq4 10 28 COVID-19 COVID-19 NNP cord-326666-melz5fq4 10 29 ) ) -RRB- cord-326666-melz5fq4 10 30 . . . cord-326666-melz5fq4 11 1 Studies study NNS cord-326666-melz5fq4 11 2 confirmed confirm VBD cord-326666-melz5fq4 11 3 significant significant JJ cord-326666-melz5fq4 11 4 genome genome NN cord-326666-melz5fq4 11 5 differences difference NNS cord-326666-melz5fq4 11 6 between between IN cord-326666-melz5fq4 11 7 SARS SARS NNP cord-326666-melz5fq4 11 8 - - HYPH cord-326666-melz5fq4 11 9 CoV-2 CoV-2 NNP cord-326666-melz5fq4 11 10 and and CC cord-326666-melz5fq4 11 11 SARS SARS NNP cord-326666-melz5fq4 11 12 - - HYPH cord-326666-melz5fq4 11 13 CoV CoV NNP cord-326666-melz5fq4 11 14 , , , cord-326666-melz5fq4 11 15 suggesting suggest VBG cord-326666-melz5fq4 11 16 that that IN cord-326666-melz5fq4 11 17 the the DT cord-326666-melz5fq4 11 18 distinctions distinction NNS cord-326666-melz5fq4 11 19 in in IN cord-326666-melz5fq4 11 20 pathogenicity pathogenicity NN cord-326666-melz5fq4 11 21 might may MD cord-326666-melz5fq4 11 22 be be VB cord-326666-melz5fq4 11 23 related relate VBN cord-326666-melz5fq4 11 24 to to IN cord-326666-melz5fq4 11 25 genomic genomic JJ cord-326666-melz5fq4 11 26 diversity diversity NN cord-326666-melz5fq4 11 27 . . . cord-326666-melz5fq4 12 1 However however RB cord-326666-melz5fq4 12 2 , , , cord-326666-melz5fq4 12 3 the the DT cord-326666-melz5fq4 12 4 relationship relationship NN cord-326666-melz5fq4 12 5 between between IN cord-326666-melz5fq4 12 6 genomic genomic JJ cord-326666-melz5fq4 12 7 differences difference NNS cord-326666-melz5fq4 12 8 and and CC cord-326666-melz5fq4 12 9 SARS SARS NNP cord-326666-melz5fq4 12 10 - - HYPH cord-326666-melz5fq4 12 11 CoV-2 CoV-2 NNP cord-326666-melz5fq4 12 12 fitness fitness NN cord-326666-melz5fq4 12 13 has have VBZ cord-326666-melz5fq4 12 14 not not RB cord-326666-melz5fq4 12 15 been be VBN cord-326666-melz5fq4 12 16 fully fully RB cord-326666-melz5fq4 12 17 explained explain VBN cord-326666-melz5fq4 12 18 , , , cord-326666-melz5fq4 12 19 especially especially RB cord-326666-melz5fq4 12 20 for for IN cord-326666-melz5fq4 12 21 open open JJ cord-326666-melz5fq4 12 22 reading reading NN cord-326666-melz5fq4 12 23 frame frame NN cord-326666-melz5fq4 12 24 ( ( -LRB- cord-326666-melz5fq4 12 25 ORF)-encoded orf)-encoded JJ cord-326666-melz5fq4 12 26 accessory accessory NN cord-326666-melz5fq4 12 27 proteins protein NNS cord-326666-melz5fq4 12 28 . . . cord-326666-melz5fq4 13 1 RNA RNA NNP cord-326666-melz5fq4 13 2 viruses virus NNS cord-326666-melz5fq4 13 3 have have VBP cord-326666-melz5fq4 13 4 a a DT cord-326666-melz5fq4 13 5 high high JJ cord-326666-melz5fq4 13 6 mutation mutation NN cord-326666-melz5fq4 13 7 rate rate NN cord-326666-melz5fq4 13 8 , , , cord-326666-melz5fq4 13 9 but but CC cord-326666-melz5fq4 13 10 how how WRB cord-326666-melz5fq4 13 11 SARS SARS NNP cord-326666-melz5fq4 13 12 - - HYPH cord-326666-melz5fq4 13 13 CoV-2 CoV-2 NNP cord-326666-melz5fq4 13 14 mutations mutation NNS cord-326666-melz5fq4 13 15 accelerate accelerate VBP cord-326666-melz5fq4 13 16 adaptation adaptation NN cord-326666-melz5fq4 13 17 is be VBZ cord-326666-melz5fq4 13 18 not not RB cord-326666-melz5fq4 13 19 clear clear JJ cord-326666-melz5fq4 13 20 . . . cord-326666-melz5fq4 14 1 This this DT cord-326666-melz5fq4 14 2 study study NN cord-326666-melz5fq4 14 3 shows show VBZ cord-326666-melz5fq4 14 4 that that IN cord-326666-melz5fq4 14 5 the the DT cord-326666-melz5fq4 14 6 host host NN cord-326666-melz5fq4 14 7 - - HYPH cord-326666-melz5fq4 14 8 genome genome NN cord-326666-melz5fq4 14 9 similarity similarity NN cord-326666-melz5fq4 14 10 ( ( -LRB- cord-326666-melz5fq4 14 11 HGS HGS NNP cord-326666-melz5fq4 14 12 ) ) -RRB- cord-326666-melz5fq4 14 13 of of IN cord-326666-melz5fq4 14 14 SARS SARS NNP cord-326666-melz5fq4 14 15 - - HYPH cord-326666-melz5fq4 14 16 CoV-2 CoV-2 NNP cord-326666-melz5fq4 14 17 is be VBZ cord-326666-melz5fq4 14 18 significantly significantly RB cord-326666-melz5fq4 14 19 higher high JJR cord-326666-melz5fq4 14 20 than than IN cord-326666-melz5fq4 14 21 that that DT cord-326666-melz5fq4 14 22 of of IN cord-326666-melz5fq4 14 23 SARS SARS NNP cord-326666-melz5fq4 14 24 - - HYPH cord-326666-melz5fq4 14 25 CoV CoV NNP cord-326666-melz5fq4 14 26 , , , cord-326666-melz5fq4 14 27 especially especially RB cord-326666-melz5fq4 14 28 in in IN cord-326666-melz5fq4 14 29 the the DT cord-326666-melz5fq4 14 30 ORF6 ORF6 NNP cord-326666-melz5fq4 14 31 and and CC cord-326666-melz5fq4 14 32 ORF8 ORF8 NNP cord-326666-melz5fq4 14 33 genes gene NNS cord-326666-melz5fq4 14 34 encoding encoding NN cord-326666-melz5fq4 14 35 proteins protein NNS cord-326666-melz5fq4 14 36 antagonizing antagonize VBG cord-326666-melz5fq4 14 37 innate innate JJ cord-326666-melz5fq4 14 38 immunity immunity NN cord-326666-melz5fq4 14 39 in in IN cord-326666-melz5fq4 14 40 vivo vivo NN cord-326666-melz5fq4 14 41 . . . cord-326666-melz5fq4 15 1 A a DT cord-326666-melz5fq4 15 2 power power NN cord-326666-melz5fq4 15 3 law law NN cord-326666-melz5fq4 15 4 relationship relationship NN cord-326666-melz5fq4 15 5 was be VBD cord-326666-melz5fq4 15 6 discovered discover VBN cord-326666-melz5fq4 15 7 between between IN cord-326666-melz5fq4 15 8 the the DT cord-326666-melz5fq4 15 9 HGS HGS NNP cord-326666-melz5fq4 15 10 of of IN cord-326666-melz5fq4 15 11 ORF3b ORF3b NNP cord-326666-melz5fq4 15 12 , , , cord-326666-melz5fq4 15 13 ORF6 ORF6 NNP cord-326666-melz5fq4 15 14 , , , cord-326666-melz5fq4 15 15 and and CC cord-326666-melz5fq4 15 16 N n CD cord-326666-melz5fq4 15 17 and and CC cord-326666-melz5fq4 15 18 the the DT cord-326666-melz5fq4 15 19 expression expression NN cord-326666-melz5fq4 15 20 of of IN cord-326666-melz5fq4 15 21 interferon interferon NN cord-326666-melz5fq4 15 22 ( ( -LRB- cord-326666-melz5fq4 15 23 IFN)-sensitive IFN)-sensitive VBG cord-326666-melz5fq4 15 24 response response NN cord-326666-melz5fq4 15 25 element element NN cord-326666-melz5fq4 15 26 ( ( -LRB- cord-326666-melz5fq4 15 27 ISRE)-containing isre)-containing NN cord-326666-melz5fq4 15 28 promoters promoter NNS cord-326666-melz5fq4 15 29 . . . cord-326666-melz5fq4 16 1 This this DT cord-326666-melz5fq4 16 2 finding finding NN cord-326666-melz5fq4 16 3 implies imply VBZ cord-326666-melz5fq4 16 4 that that IN cord-326666-melz5fq4 16 5 high high JJ cord-326666-melz5fq4 16 6 HGS hgs NN cord-326666-melz5fq4 16 7 of of IN cord-326666-melz5fq4 16 8 SARS SARS NNP cord-326666-melz5fq4 16 9 - - HYPH cord-326666-melz5fq4 16 10 CoV-2 CoV-2 NNP cord-326666-melz5fq4 16 11 genome genome NN cord-326666-melz5fq4 16 12 may may MD cord-326666-melz5fq4 16 13 further far RBR cord-326666-melz5fq4 16 14 inhibit inhibit VB cord-326666-melz5fq4 16 15 IFN IFN NNP cord-326666-melz5fq4 16 16 I -PRON- PRP cord-326666-melz5fq4 16 17 synthesis synthesis NN cord-326666-melz5fq4 16 18 and and CC cord-326666-melz5fq4 16 19 cause cause VB cord-326666-melz5fq4 16 20 delayed delay VBN cord-326666-melz5fq4 16 21 host host NN cord-326666-melz5fq4 16 22 innate innate JJ cord-326666-melz5fq4 16 23 immunity immunity NN cord-326666-melz5fq4 16 24 . . . cord-326666-melz5fq4 17 1 An an DT cord-326666-melz5fq4 17 2 ORF1ab ORF1ab NNP cord-326666-melz5fq4 17 3 mutation mutation NN cord-326666-melz5fq4 17 4 , , , cord-326666-melz5fq4 17 5 10818 10818 CD cord-326666-melz5fq4 17 6 G g NN cord-326666-melz5fq4 18 1 > > XX cord-326666-melz5fq4 19 1 T T NNP cord-326666-melz5fq4 19 2 , , , cord-326666-melz5fq4 19 3 which which WDT cord-326666-melz5fq4 19 4 occurred occur VBD cord-326666-melz5fq4 19 5 in in IN cord-326666-melz5fq4 19 6 virus virus NN cord-326666-melz5fq4 19 7 populations population NNS cord-326666-melz5fq4 19 8 with with IN cord-326666-melz5fq4 19 9 high high JJ cord-326666-melz5fq4 19 10 HGS hgs NN cord-326666-melz5fq4 19 11 but but CC cord-326666-melz5fq4 19 12 rarely rarely RB cord-326666-melz5fq4 19 13 in in IN cord-326666-melz5fq4 19 14 low low JJ cord-326666-melz5fq4 19 15 - - HYPH cord-326666-melz5fq4 19 16 HGS hgs NN cord-326666-melz5fq4 19 17 populations population NNS cord-326666-melz5fq4 19 18 , , , cord-326666-melz5fq4 19 19 was be VBD cord-326666-melz5fq4 19 20 identified identify VBN cord-326666-melz5fq4 19 21 in in IN cord-326666-melz5fq4 19 22 2594 2594 CD cord-326666-melz5fq4 19 23 genomes genome NNS cord-326666-melz5fq4 19 24 with with IN cord-326666-melz5fq4 19 25 geolocations geolocation NNS cord-326666-melz5fq4 19 26 of of IN cord-326666-melz5fq4 19 27 China China NNP cord-326666-melz5fq4 19 28 , , , cord-326666-melz5fq4 19 29 the the DT cord-326666-melz5fq4 19 30 USA USA NNP cord-326666-melz5fq4 19 31 and and CC cord-326666-melz5fq4 19 32 Europe Europe NNP cord-326666-melz5fq4 19 33 . . . cord-326666-melz5fq4 20 1 The the DT cord-326666-melz5fq4 20 2 10818 10818 CD cord-326666-melz5fq4 20 3 G g NN cord-326666-melz5fq4 21 1 > > XX cord-326666-melz5fq4 22 1 T T NNP cord-326666-melz5fq4 22 2 caused cause VBD cord-326666-melz5fq4 22 3 the the DT cord-326666-melz5fq4 22 4 amino amino NN cord-326666-melz5fq4 22 5 acid acid NN cord-326666-melz5fq4 22 6 mutation mutation NN cord-326666-melz5fq4 22 7 M37F m37f NN cord-326666-melz5fq4 22 8 in in IN cord-326666-melz5fq4 22 9 the the DT cord-326666-melz5fq4 22 10 transmembrane transmembrane NNP cord-326666-melz5fq4 22 11 protein protein NN cord-326666-melz5fq4 22 12 nsp6 nsp6 RB cord-326666-melz5fq4 22 13 . . . cord-326666-melz5fq4 23 1 The the DT cord-326666-melz5fq4 23 2 results result NNS cord-326666-melz5fq4 23 3 suggest suggest VBP cord-326666-melz5fq4 23 4 that that IN cord-326666-melz5fq4 23 5 the the DT cord-326666-melz5fq4 23 6 ORF6 ORF6 NNP cord-326666-melz5fq4 23 7 and and CC cord-326666-melz5fq4 23 8 ORF8 ORF8 NNP cord-326666-melz5fq4 23 9 genes gene NNS cord-326666-melz5fq4 23 10 and and CC cord-326666-melz5fq4 23 11 the the DT cord-326666-melz5fq4 23 12 mutation mutation NN cord-326666-melz5fq4 23 13 M37F m37f NN cord-326666-melz5fq4 23 14 may may MD cord-326666-melz5fq4 23 15 play play VB cord-326666-melz5fq4 23 16 important important JJ cord-326666-melz5fq4 23 17 roles role NNS cord-326666-melz5fq4 23 18 in in IN cord-326666-melz5fq4 23 19 causing cause VBG cord-326666-melz5fq4 23 20 COVID-19 covid-19 NN cord-326666-melz5fq4 23 21 . . . cord-326666-melz5fq4 24 1 The the DT cord-326666-melz5fq4 24 2 findings finding NNS cord-326666-melz5fq4 24 3 demonstrate demonstrate VBP cord-326666-melz5fq4 24 4 that that IN cord-326666-melz5fq4 24 5 HGS HGS NNP cord-326666-melz5fq4 24 6 analysis analysis NN cord-326666-melz5fq4 24 7 is be VBZ cord-326666-melz5fq4 24 8 a a DT cord-326666-melz5fq4 24 9 promising promising JJ cord-326666-melz5fq4 24 10 way way NN cord-326666-melz5fq4 24 11 to to TO cord-326666-melz5fq4 24 12 identify identify VB cord-326666-melz5fq4 24 13 important important JJ cord-326666-melz5fq4 24 14 genes gene NNS cord-326666-melz5fq4 24 15 and and CC cord-326666-melz5fq4 24 16 mutations mutation NNS cord-326666-melz5fq4 24 17 in in IN cord-326666-melz5fq4 24 18 adaptive adaptive JJ cord-326666-melz5fq4 24 19 strains strain NNS cord-326666-melz5fq4 24 20 , , , cord-326666-melz5fq4 24 21 which which WDT cord-326666-melz5fq4 24 22 may may MD cord-326666-melz5fq4 24 23 help help VB cord-326666-melz5fq4 24 24 in in IN cord-326666-melz5fq4 24 25 searching search VBG cord-326666-melz5fq4 24 26 potential potential JJ cord-326666-melz5fq4 24 27 targets target NNS cord-326666-melz5fq4 24 28 for for IN cord-326666-melz5fq4 24 29 pharmaceutical pharmaceutical JJ cord-326666-melz5fq4 24 30 agents agent NNS cord-326666-melz5fq4 24 31 . . . cord-326666-melz5fq4 25 1 In in IN cord-326666-melz5fq4 25 2 December December NNP cord-326666-melz5fq4 25 3 2019 2019 CD cord-326666-melz5fq4 25 4 , , , cord-326666-melz5fq4 25 5 a a DT cord-326666-melz5fq4 25 6 novel novel JJ cord-326666-melz5fq4 25 7 coronavirus coronavirus NN cord-326666-melz5fq4 25 8 SARS SARS NNP cord-326666-melz5fq4 25 9 - - HYPH cord-326666-melz5fq4 25 10 CoV-2 CoV-2 NNP cord-326666-melz5fq4 25 11 was be VBD cord-326666-melz5fq4 25 12 reported report VBN cord-326666-melz5fq4 25 13 as as IN cord-326666-melz5fq4 25 14 the the DT cord-326666-melz5fq4 25 15 cause cause NN cord-326666-melz5fq4 25 16 of of IN cord-326666-melz5fq4 25 17 COVID-19 COVID-19 NNP cord-326666-melz5fq4 25 18 . . . cord-326666-melz5fq4 26 1 SARS SARS NNP cord-326666-melz5fq4 26 2 - - HYPH cord-326666-melz5fq4 26 3 CoV-2 CoV-2 NNP cord-326666-melz5fq4 26 4 40 40 CD cord-326666-melz5fq4 26 5 has have VBZ cord-326666-melz5fq4 26 6 a a DT cord-326666-melz5fq4 26 7 positive positive JJ cord-326666-melz5fq4 26 8 - - HYPH cord-326666-melz5fq4 26 9 sense sense NN cord-326666-melz5fq4 26 10 single single JJ cord-326666-melz5fq4 26 11 - - HYPH cord-326666-melz5fq4 26 12 stranded strand VBN cord-326666-melz5fq4 26 13 RNA RNA NNP cord-326666-melz5fq4 26 14 with with IN cord-326666-melz5fq4 26 15 a a DT cord-326666-melz5fq4 26 16 length length NN cord-326666-melz5fq4 26 17 of of IN cord-326666-melz5fq4 26 18 approximately approximately RB cord-326666-melz5fq4 26 19 30 30 CD cord-326666-melz5fq4 26 20 kb kb NNP cord-326666-melz5fq4 26 21 [ [ -LRB- cord-326666-melz5fq4 26 22 1 1 CD cord-326666-melz5fq4 26 23 ] ] -RRB- cord-326666-melz5fq4 26 24 . . . cord-326666-melz5fq4 27 1 Studies study NNS cord-326666-melz5fq4 27 2 have have VBP cord-326666-melz5fq4 27 3 shown show VBN cord-326666-melz5fq4 27 4 that that IN cord-326666-melz5fq4 27 5 41 41 CD cord-326666-melz5fq4 27 6 considerable considerable JJ cord-326666-melz5fq4 27 7 genetic genetic JJ cord-326666-melz5fq4 27 8 diversity diversity NN cord-326666-melz5fq4 27 9 exists exist VBZ cord-326666-melz5fq4 27 10 between between IN cord-326666-melz5fq4 27 11 SARS SARS NNP cord-326666-melz5fq4 27 12 - - HYPH cord-326666-melz5fq4 27 13 CoV-2 CoV-2 NNP cord-326666-melz5fq4 27 14 and and CC cord-326666-melz5fq4 27 15 SARS SARS NNP cord-326666-melz5fq4 27 16 - - HYPH cord-326666-melz5fq4 27 17 CoV CoV NNP cord-326666-melz5fq4 27 18 [ [ -LRB- cord-326666-melz5fq4 27 19 1 1 CD cord-326666-melz5fq4 27 20 , , , cord-326666-melz5fq4 27 21 2 2 CD cord-326666-melz5fq4 27 22 ] ] -RRB- cord-326666-melz5fq4 27 23 . . . cord-326666-melz5fq4 28 1 Compared compare VBN cord-326666-melz5fq4 28 2 with with IN cord-326666-melz5fq4 28 3 SARS SARS NNP cord-326666-melz5fq4 28 4 - - : cord-326666-melz5fq4 28 5 speculated speculate VBD cord-326666-melz5fq4 28 6 that that IN cord-326666-melz5fq4 28 7 some some DT cord-326666-melz5fq4 28 8 genes gene NNS cord-326666-melz5fq4 28 9 of of IN cord-326666-melz5fq4 28 10 the the DT cord-326666-melz5fq4 28 11 two two CD cord-326666-melz5fq4 28 12 viruses virus NNS cord-326666-melz5fq4 28 13 may may MD cord-326666-melz5fq4 28 14 also also RB cord-326666-melz5fq4 28 15 exist exist VB cord-326666-melz5fq4 28 16 in in IN cord-326666-melz5fq4 28 17 the the DT cord-326666-melz5fq4 28 18 human human JJ cord-326666-melz5fq4 28 19 genome genome NN cord-326666-melz5fq4 28 20 or or CC cord-326666-melz5fq4 28 21 that that IN cord-326666-melz5fq4 28 22 the the DT cord-326666-melz5fq4 28 23 viruses virus NNS cord-326666-melz5fq4 28 24 may may MD cord-326666-melz5fq4 28 25 111 111 CD cord-326666-melz5fq4 28 26 may may MD cord-326666-melz5fq4 28 27 accelerate accelerate VB cord-326666-melz5fq4 28 28 adaptation adaptation NN cord-326666-melz5fq4 28 29 in in IN cord-326666-melz5fq4 28 30 humans human NNS cord-326666-melz5fq4 28 31 through through IN cord-326666-melz5fq4 28 32 increasing increase VBG cord-326666-melz5fq4 28 33 HGS HGS NNP cord-326666-melz5fq4 28 34 of of IN cord-326666-melz5fq4 28 35 the the DT cord-326666-melz5fq4 28 36 ORF6 ORF6 NNP cord-326666-melz5fq4 28 37 and and CC cord-326666-melz5fq4 28 38 ORF8 ORF8 NNP cord-326666-melz5fq4 28 39 genes gene NNS cord-326666-melz5fq4 28 40 and and CC cord-326666-melz5fq4 28 41 112 112 CD cord-326666-melz5fq4 28 42 selecting select VBG cord-326666-melz5fq4 28 43 the the DT cord-326666-melz5fq4 28 44 M37F m37f NN cord-326666-melz5fq4 28 45 mutation mutation NN cord-326666-melz5fq4 28 46 . . . cord-326666-melz5fq4 29 1 However however RB cord-326666-melz5fq4 29 2 , , , cord-326666-melz5fq4 29 3 the the DT cord-326666-melz5fq4 29 4 underlying underlying JJ cord-326666-melz5fq4 29 5 mechanism mechanism NN cord-326666-melz5fq4 29 6 by by IN cord-326666-melz5fq4 29 7 which which WDT cord-326666-melz5fq4 29 8 these these DT cord-326666-melz5fq4 29 9 genes gene NNS cord-326666-melz5fq4 29 10 and and CC cord-326666-melz5fq4 29 11 113 113 CD cord-326666-melz5fq4 29 12 mutations mutation NNS cord-326666-melz5fq4 29 13 make make VBP cord-326666-melz5fq4 29 14 SARS SARS NNP cord-326666-melz5fq4 29 15 - - HYPH cord-326666-melz5fq4 29 16 CoV-2 CoV-2 NNP cord-326666-melz5fq4 29 17 more more RBR cord-326666-melz5fq4 29 18 adapted adapt VBN cord-326666-melz5fq4 29 19 to to IN cord-326666-melz5fq4 29 20 humans human NNS cord-326666-melz5fq4 29 21 remains remain VBZ cord-326666-melz5fq4 29 22 unclear unclear JJ cord-326666-melz5fq4 29 23 . . . cord-326666-melz5fq4 29 24 _SP cord-326666-melz5fq4 30 1 140 140 CD cord-326666-melz5fq4 30 2 . . . cord-326666-melz5fq4 31 1 ( ( -LRB- cord-326666-melz5fq4 31 2 2 2 LS cord-326666-melz5fq4 31 3 ) ) -RRB- cord-326666-melz5fq4 31 4 141 141 CD cord-326666-melz5fq4 31 5 Here here RB cord-326666-melz5fq4 32 1 , , , cord-326666-melz5fq4 32 2 the the DT cord-326666-melz5fq4 32 3 E e NN cord-326666-melz5fq4 32 4 value value NN cord-326666-melz5fq4 32 5 represents represent VBZ cord-326666-melz5fq4 32 6 the the DT cord-326666-melz5fq4 32 7 expected expect VBN cord-326666-melz5fq4 32 8 number number NN cord-326666-melz5fq4 32 9 of of IN cord-326666-melz5fq4 32 10 times time NNS cord-326666-melz5fq4 32 11 when when WRB cord-326666-melz5fq4 32 12 two two CD cord-326666-melz5fq4 32 13 random random JJ cord-326666-melz5fq4 32 14 sequences sequence NNS cord-326666-melz5fq4 32 15 of of IN cord-326666-melz5fq4 32 16 length length NN cord-326666-melz5fq4 32 17 m m NN cord-326666-melz5fq4 32 18 and and CC cord-326666-melz5fq4 32 19 n n NNP cord-326666-melz5fq4 32 20 142 142 CD cord-326666-melz5fq4 32 21 are be VBP cord-326666-melz5fq4 32 22 matched match VBN cord-326666-melz5fq4 32 23 and and CC cord-326666-melz5fq4 32 24 the the DT cord-326666-melz5fq4 32 25 score score NN cord-326666-melz5fq4 32 26 is be VBZ cord-326666-melz5fq4 32 27 not not RB cord-326666-melz5fq4 32 28 lower low JJR cord-326666-melz5fq4 32 29 than than IN cord-326666-melz5fq4 32 30 S S NNP cord-326666-melz5fq4 32 31 ' ' '' cord-326666-melz5fq4 32 32 . . . cord-326666-melz5fq4 33 1 Parameters parameter NNS cord-326666-melz5fq4 33 2 K K NNP cord-326666-melz5fq4 33 3 and and CC cord-326666-melz5fq4 33 4 λ λ NN cord-326666-melz5fq4 33 5 describe describe VBP cord-326666-melz5fq4 33 6 the the DT cord-326666-melz5fq4 33 7 statistical statistical JJ cord-326666-melz5fq4 33 8 significance significance NN cord-326666-melz5fq4 33 9 of of IN cord-326666-melz5fq4 33 10 the the DT cord-326666-melz5fq4 33 11 143 143 CD cord-326666-melz5fq4 33 12 results result NNS cord-326666-melz5fq4 33 13 [ [ -LRB- cord-326666-melz5fq4 33 14 18 18 CD cord-326666-melz5fq4 33 15 ] ] -RRB- cord-326666-melz5fq4 33 16 . . . cord-326666-melz5fq4 34 1 Assuming assume VBG cord-326666-melz5fq4 34 2 that that IN cord-326666-melz5fq4 34 3 the the DT cord-326666-melz5fq4 34 4 fragment fragment NN cord-326666-melz5fq4 34 5 of of IN cord-326666-melz5fq4 34 6 length length NN cord-326666-melz5fq4 34 7 matches match NNS cord-326666-melz5fq4 34 8 perfectly perfectly RB cord-326666-melz5fq4 34 9 in in IN cord-326666-melz5fq4 34 10 the the DT cord-326666-melz5fq4 34 11 two two CD cord-326666-melz5fq4 34 12 random random JJ cord-326666-melz5fq4 34 13 sequences sequence NNS cord-326666-melz5fq4 34 14 , , , cord-326666-melz5fq4 34 15 one one PRP cord-326666-melz5fq4 34 16 has have VBZ cord-326666-melz5fq4 34 17 144 144 CD cord-326666-melz5fq4 35 1 the the DT cord-326666-melz5fq4 35 2 following follow VBG cord-326666-melz5fq4 35 3 formula formula NN cord-326666-melz5fq4 35 4 : : : cord-326666-melz5fq4 35 5 145 145 CD cord-326666-melz5fq4 35 6 . . . cord-326666-melz5fq4 36 1 ( ( -LRB- cord-326666-melz5fq4 36 2 3 3 LS cord-326666-melz5fq4 36 3 ) ) -RRB- cord-326666-melz5fq4 37 1 Since since IN cord-326666-melz5fq4 37 2 the the DT cord-326666-melz5fq4 37 3 viral viral JJ cord-326666-melz5fq4 37 4 genome genome NN cord-326666-melz5fq4 37 5 is be VBZ cord-326666-melz5fq4 37 6 quite quite RB cord-326666-melz5fq4 37 7 different different JJ cord-326666-melz5fq4 37 8 from from IN cord-326666-melz5fq4 37 9 the the DT cord-326666-melz5fq4 37 10 human human JJ cord-326666-melz5fq4 37 11 genome genome NN cord-326666-melz5fq4 37 12 , , , cord-326666-melz5fq4 37 13 matching match VBG cord-326666-melz5fq4 37 14 fragments fragment NNS cord-326666-melz5fq4 37 15 are be VBP cord-326666-melz5fq4 37 16 usually usually RB cord-326666-melz5fq4 37 17 very very RB cord-326666-melz5fq4 37 18 short short JJ cord-326666-melz5fq4 37 19 . . . cord-326666-melz5fq4 38 1 When when WRB cord-326666-melz5fq4 38 2 is be VBZ cord-326666-melz5fq4 38 3 particularly particularly RB cord-326666-melz5fq4 38 4 small small JJ cord-326666-melz5fq4 38 5 compared compare VBN cord-326666-melz5fq4 38 6 to to IN cord-326666-melz5fq4 38 7 and and CC cord-326666-melz5fq4 38 8 , , , cord-326666-melz5fq4 38 9 is be VBZ cord-326666-melz5fq4 38 10 obtained obtain VBN cord-326666-melz5fq4 38 11 by by IN cord-326666-melz5fq4 38 12 combining combine VBG cord-326666-melz5fq4 38 13 Equation equation NN cord-326666-melz5fq4 38 14 ( ( -LRB- cord-326666-melz5fq4 38 15 3 3 CD cord-326666-melz5fq4 38 16 ) ) -RRB- cord-326666-melz5fq4 38 17 _SP cord-326666-melz5fq4 38 18 The the DT cord-326666-melz5fq4 38 19 SARS SARS NNP cord-326666-melz5fq4 38 20 - - HYPH cord-326666-melz5fq4 38 21 CoV-2 CoV-2 NNP cord-326666-melz5fq4 38 22 ( ( -LRB- cord-326666-melz5fq4 38 23 GenBank GenBank NNP cord-326666-melz5fq4 38 24 : : : cord-326666-melz5fq4 38 25 MN908947.3 MN908947.3 NNP cord-326666-melz5fq4 38 26 ) ) -RRB- cord-326666-melz5fq4 38 27 and and CC cord-326666-melz5fq4 38 28 SARS SARS NNP cord-326666-melz5fq4 38 29 - - HYPH cord-326666-melz5fq4 38 30 CoV CoV NNP cord-326666-melz5fq4 38 31 ( ( -LRB- cord-326666-melz5fq4 38 32 GenBank GenBank NNP cord-326666-melz5fq4 38 33 : : : cord-326666-melz5fq4 39 1 AY394850.2 AY394850.2 NNP cord-326666-melz5fq4 39 2 ) ) -RRB- cord-326666-melz5fq4 39 3 RNA RNA NNP cord-326666-melz5fq4 39 4 sequences sequence NNS cord-326666-melz5fq4 39 5 162 162 CD cord-326666-melz5fq4 39 6 were be VBD cord-326666-melz5fq4 39 7 used use VBN cord-326666-melz5fq4 39 8 as as IN cord-326666-melz5fq4 39 9 references reference NNS cord-326666-melz5fq4 39 10 to to TO cord-326666-melz5fq4 39 11 establish establish VB cord-326666-melz5fq4 39 12 the the DT cord-326666-melz5fq4 39 13 genome genome NN cord-326666-melz5fq4 39 14 organization organization NN cord-326666-melz5fq4 39 15 . . . cord-326666-melz5fq4 40 1 SARS SARS NNP cord-326666-melz5fq4 40 2 - - HYPH cord-326666-melz5fq4 40 3 CoV-2 CoV-2 NNP cord-326666-melz5fq4 40 4 has have VBZ cord-326666-melz5fq4 40 5 14 14 CD cord-326666-melz5fq4 40 6 5'-ORFs 5'-orfs CD cord-326666-melz5fq4 40 7 , , , cord-326666-melz5fq4 40 8 while while IN cord-326666-melz5fq4 40 9 SARS-163 SARS-163 NNP cord-326666-melz5fq4 40 10 CoV CoV NNP cord-326666-melz5fq4 40 11 has have VBZ cord-326666-melz5fq4 40 12 19 19 CD cord-326666-melz5fq4 40 13 5'-ORFs 5'-orfs CD cord-326666-melz5fq4 40 14 . . . cord-326666-melz5fq4 41 1 The the DT cord-326666-melz5fq4 41 2 length length NN cord-326666-melz5fq4 41 3 of of IN cord-326666-melz5fq4 41 4 each each DT cord-326666-melz5fq4 41 5 ORF ORF NNP cord-326666-melz5fq4 41 6 is be VBZ cord-326666-melz5fq4 41 7 no no DT cord-326666-melz5fq4 41 8 less less JJR cord-326666-melz5fq4 41 9 than than IN cord-326666-melz5fq4 41 10 75 75 CD cord-326666-melz5fq4 41 11 nt nt NN cord-326666-melz5fq4 41 12 ( ( -LRB- cord-326666-melz5fq4 41 13 Table table NN cord-326666-melz5fq4 41 14 1 1 CD cord-326666-melz5fq4 41 15 ) ) -RRB- cord-326666-melz5fq4 41 16 . . . cord-326666-melz5fq4 42 1 A a DT cord-326666-melz5fq4 42 2 quantitative quantitative JJ cord-326666-melz5fq4 42 3 definition definition NN cord-326666-melz5fq4 42 4 of of IN cord-326666-melz5fq4 42 5 HGS HGS NNP cord-326666-melz5fq4 42 6 was be VBD cord-326666-melz5fq4 42 7 proposed propose VBN cord-326666-melz5fq4 42 8 to to TO cord-326666-melz5fq4 42 9 investigate investigate VB cord-326666-melz5fq4 42 10 the the DT cord-326666-melz5fq4 42 11 similarity similarity NN cord-326666-melz5fq4 42 12 between between IN cord-326666-melz5fq4 42 13 viral viral JJ cord-326666-melz5fq4 42 14 coding coding NN cord-326666-melz5fq4 42 15 sequences sequence NNS cord-326666-melz5fq4 42 16 165 165 CD cord-326666-melz5fq4 42 17 ( ( -LRB- cord-326666-melz5fq4 42 18 CDSs CDSs NNP cord-326666-melz5fq4 42 19 ) ) -RRB- cord-326666-melz5fq4 42 20 and and CC cord-326666-melz5fq4 42 21 the the DT cord-326666-melz5fq4 42 22 human human JJ cord-326666-melz5fq4 42 23 genome genome NN cord-326666-melz5fq4 43 1 ( ( -LRB- cord-326666-melz5fq4 43 2 Homo homo JJ cord-326666-melz5fq4 43 3 sapiens sapiens JJ cord-326666-melz5fq4 43 4 GRCh38.p12 GRCh38.p12 NNP cord-326666-melz5fq4 43 5 chromosomes chromosome NNS cord-326666-melz5fq4 43 6 ) ) -RRB- cord-326666-melz5fq4 43 7 . . . cord-326666-melz5fq4 44 1 The the DT cord-326666-melz5fq4 44 2 CDS CDS NNP cord-326666-melz5fq4 44 3 alignment alignment NN cord-326666-melz5fq4 44 4 scores score NNS cord-326666-melz5fq4 44 5 were be VBD cord-326666-melz5fq4 44 6 166 166 CD cord-326666-melz5fq4 44 7 determined determine VBN cord-326666-melz5fq4 44 8 by by IN cord-326666-melz5fq4 44 9 using use VBG cord-326666-melz5fq4 44 10 NCBI NCBI NNP cord-326666-melz5fq4 44 11 Blastn[17 Blastn[17 NNP cord-326666-melz5fq4 44 12 ] ] -RRB- cord-326666-melz5fq4 44 13 , , , cord-326666-melz5fq4 44 14 and and CC cord-326666-melz5fq4 44 15 HGS HGS NNP cord-326666-melz5fq4 44 16 was be VBD cord-326666-melz5fq4 44 17 calculated calculate VBN cord-326666-melz5fq4 44 18 by by IN cord-326666-melz5fq4 44 19 the the DT cord-326666-melz5fq4 44 20 formulas formula NNS cord-326666-melz5fq4 44 21 described describe VBN cord-326666-melz5fq4 44 22 in in IN cord-326666-melz5fq4 44 23 the the DT cord-326666-melz5fq4 44 24 Methods Methods NNPS cord-326666-melz5fq4 44 25 167 167 CD cord-326666-melz5fq4 44 26 for for IN cord-326666-melz5fq4 44 27 each each DT cord-326666-melz5fq4 44 28 ORF ORF NNP cord-326666-melz5fq4 44 29 in in IN cord-326666-melz5fq4 44 30 the the DT cord-326666-melz5fq4 44 31 coronavirus coronavirus NN cord-326666-melz5fq4 44 32 genome genome NN cord-326666-melz5fq4 44 33 . . . cord-326666-melz5fq4 45 1 The the DT cord-326666-melz5fq4 45 2 overall overall JJ cord-326666-melz5fq4 45 3 HGS hgs NN cord-326666-melz5fq4 45 4 of of IN cord-326666-melz5fq4 45 5 a a DT cord-326666-melz5fq4 45 6 full full JJ cord-326666-melz5fq4 45 7 - - HYPH cord-326666-melz5fq4 45 8 length length NN cord-326666-melz5fq4 45 9 virus virus NN cord-326666-melz5fq4 45 10 genome genome NN cord-326666-melz5fq4 45 11 was be VBD cord-326666-melz5fq4 45 12 obtained obtain VBN cord-326666-melz5fq4 45 13 by by IN cord-326666-melz5fq4 45 14 168 168 CD cord-326666-melz5fq4 45 15 the the DT cord-326666-melz5fq4 45 16 weighted weighted JJ cord-326666-melz5fq4 45 17 sum sum NN cord-326666-melz5fq4 45 18 of of IN cord-326666-melz5fq4 45 19 ORF ORF NNP cord-326666-melz5fq4 45 20 HGSs HGSs NNP cord-326666-melz5fq4 45 21 . . . cord-326666-melz5fq4 46 1 The the DT cord-326666-melz5fq4 46 2 weighting weighting NN cord-326666-melz5fq4 46 3 factor factor NN cord-326666-melz5fq4 46 4 was be VBD cord-326666-melz5fq4 46 5 the the DT cord-326666-melz5fq4 46 6 ratio ratio NN cord-326666-melz5fq4 46 7 of of IN cord-326666-melz5fq4 46 8 ORF ORF NNP cord-326666-melz5fq4 46 9 length length NN cord-326666-melz5fq4 46 10 to to IN cord-326666-melz5fq4 46 11 the the DT cord-326666-melz5fq4 46 12 full full JJ cord-326666-melz5fq4 46 13 - - HYPH cord-326666-melz5fq4 46 14 genome genome NN cord-326666-melz5fq4 46 15 length length NN cord-326666-melz5fq4 46 16 . . . cord-326666-melz5fq4 47 1 The the DT cord-326666-melz5fq4 47 2 ORF ORF NNP cord-326666-melz5fq4 47 3 lengths length NNS cord-326666-melz5fq4 47 4 of of IN cord-326666-melz5fq4 47 5 SARS SARS NNP cord-326666-melz5fq4 47 6 - - HYPH cord-326666-melz5fq4 47 7 CoV CoV NNP cord-326666-melz5fq4 47 8 and and CC cord-326666-melz5fq4 47 9 SARS SARS NNP cord-326666-melz5fq4 47 10 - - HYPH cord-326666-melz5fq4 47 11 CoV-2 CoV-2 NNP cord-326666-melz5fq4 47 12 genomes genome NNS cord-326666-melz5fq4 47 13 are be VBP cord-326666-melz5fq4 47 14 given give VBN cord-326666-melz5fq4 47 15 in in IN cord-326666-melz5fq4 47 16 Table Table NNP cord-326666-melz5fq4 47 17 1 1 CD cord-326666-melz5fq4 47 18 . . . cord-326666-melz5fq4 48 1 R R NNP cord-326666-melz5fq4 48 2 13685 13685 CD cord-326666-melz5fq4 48 3 _SP cord-326666-melz5fq4 49 1 13759 13759 CD cord-326666-melz5fq4 49 2 _SP cord-326666-melz5fq4 50 1 75 75 CD cord-326666-melz5fq4 50 2 _SP cord-326666-melz5fq4 51 1 24 24 CD cord-326666-melz5fq4 51 2 _SP cord-326666-melz5fq4 51 3 13685 13685 CD cord-326666-melz5fq4 51 4 13759 13759 CD cord-326666-melz5fq4 52 1 75 75 CD cord-326666-melz5fq4 52 2 _SP cord-326666-melz5fq4 53 1 24 24 CD cord-326666-melz5fq4 53 2 _SP cord-326666-melz5fq4 54 1 ORF1b ORF1b NNP cord-326666-melz5fq4 54 2 _SP cord-326666-melz5fq4 55 1 ORF1b ORF1b NNP cord-326666-melz5fq4 55 2 _SP cord-326666-melz5fq4 56 1 1b 1b NNP cord-326666-melz5fq4 56 2 _SP cord-326666-melz5fq4 57 1 13398 13398 CD cord-326666-melz5fq4 57 2 _SP cord-326666-melz5fq4 58 1 21485 21485 CD cord-326666-melz5fq4 58 2 _SP cord-326666-melz5fq4 59 1 8088 8088 CD cord-326666-melz5fq4 59 2 _SP cord-326666-melz5fq4 60 1 2628 2628 CD cord-326666-melz5fq4 60 2 _SP cord-326666-melz5fq4 60 3 13768 13768 CD cord-326666-melz5fq4 60 4 21555 21555 CD cord-326666-melz5fq4 61 1 7788 7788 CD cord-326666-melz5fq4 61 2 _SP cord-326666-melz5fq4 62 1 2595 2595 CD cord-326666-melz5fq4 62 2 _SP cord-326666-melz5fq4 63 1 S S NNP cord-326666-melz5fq4 63 2 _SP cord-326666-melz5fq4 64 1 Sprotein Sprotein NNP cord-326666-melz5fq4 64 2 _SP cord-326666-melz5fq4 65 1 S S NNP cord-326666-melz5fq4 65 2 _SP cord-326666-melz5fq4 66 1 21492 21492 CD cord-326666-melz5fq4 66 2 _SP cord-326666-melz5fq4 67 1 25259 25259 CD cord-326666-melz5fq4 67 2 _SP cord-326666-melz5fq4 68 1 3768 3768 CD cord-326666-melz5fq4 68 2 _SP cord-326666-melz5fq4 69 1 1282 1282 CD cord-326666-melz5fq4 69 2 _SP cord-326666-melz5fq4 69 3 21536 21536 CD cord-326666-melz5fq4 69 4 25384 25384 CD cord-326666-melz5fq4 70 1 3849 3849 CD cord-326666-melz5fq4 70 2 _SP cord-326666-melz5fq4 71 1 1282 1282 CD cord-326666-melz5fq4 71 2 _SP cord-326666-melz5fq4 72 1 N N NNP cord-326666-melz5fq4 72 2 / / SYM cord-326666-melz5fq4 72 3 R R NNP cord-326666-melz5fq4 72 4 _SP cord-326666-melz5fq4 72 5 N N NNP cord-326666-melz5fq4 72 6 / / SYM cord-326666-melz5fq4 72 7 R R NNP cord-326666-melz5fq4 72 8 _SP cord-326666-melz5fq4 72 9 N N NNP cord-326666-melz5fq4 72 10 / / SYM cord-326666-melz5fq4 72 11 R R NNP cord-326666-melz5fq4 72 12 25207 25207 CD cord-326666-melz5fq4 72 13 _SP cord-326666-melz5fq4 73 1 25329 25329 CD cord-326666-melz5fq4 73 2 _SP cord-326666-melz5fq4 74 1 123 123 CD cord-326666-melz5fq4 74 2 _SP cord-326666-melz5fq4 74 3 40 40 CD cord-326666-melz5fq4 74 4 _SP cord-326666-melz5fq4 74 5 25332 25332 CD cord-326666-melz5fq4 74 6 25448 25448 CD cord-326666-melz5fq4 75 1 117 117 CD cord-326666-melz5fq4 75 2 _SP cord-326666-melz5fq4 76 1 38 38 CD cord-326666-melz5fq4 76 2 _SP cord-326666-melz5fq4 76 3 ORF3a orf3a XX cord-326666-melz5fq4 76 4 _SP cord-326666-melz5fq4 77 1 ORF3 ORF3 NNP cord-326666-melz5fq4 77 2 _SP cord-326666-melz5fq4 78 1 X1 X1 NNP cord-326666-melz5fq4 78 2 _SP cord-326666-melz5fq4 79 1 25268 25268 CD cord-326666-melz5fq4 79 2 _SP cord-326666-melz5fq4 80 1 26092 26092 CD cord-326666-melz5fq4 80 2 _SP cord-326666-melz5fq4 81 1 825 825 CD cord-326666-melz5fq4 81 2 _SP cord-326666-melz5fq4 81 3 274 274 CD cord-326666-melz5fq4 81 4 _SP cord-326666-melz5fq4 81 5 25393 25393 CD cord-326666-melz5fq4 81 6 26220 26220 CD cord-326666-melz5fq4 82 1 828 828 CD cord-326666-melz5fq4 82 2 _SP cord-326666-melz5fq4 83 1 275 275 CD cord-326666-melz5fq4 83 2 _SP cord-326666-melz5fq4 84 1 E E NNP cord-326666-melz5fq4 84 2 _SP cord-326666-melz5fq4 84 3 Eprotein Eprotein NNP cord-326666-melz5fq4 84 4 E E NNP cord-326666-melz5fq4 84 5 _SP cord-326666-melz5fq4 85 1 26117 26117 CD cord-326666-melz5fq4 85 2 _SP cord-326666-melz5fq4 86 1 26347 26347 CD cord-326666-melz5fq4 86 2 _SP cord-326666-melz5fq4 87 1 231 231 CD cord-326666-melz5fq4 87 2 _SP cord-326666-melz5fq4 87 3 76 76 CD cord-326666-melz5fq4 87 4 _SP cord-326666-melz5fq4 88 1 26245 26245 CD cord-326666-melz5fq4 88 2 26472 26472 CD cord-326666-melz5fq4 89 1 228 228 CD cord-326666-melz5fq4 89 2 _SP cord-326666-melz5fq4 90 1 75 75 CD cord-326666-melz5fq4 90 2 _SP cord-326666-melz5fq4 91 1 M M NNP cord-326666-melz5fq4 91 2 _SP cord-326666-melz5fq4 92 1 Mprotein Mprotein NNP cord-326666-melz5fq4 92 2 M M NNP cord-326666-melz5fq4 92 3 _SP cord-326666-melz5fq4 92 4 26398 26398 CD cord-326666-melz5fq4 92 5 _SP cord-326666-melz5fq4 93 1 27063 27063 CD cord-326666-melz5fq4 93 2 _SP cord-326666-melz5fq4 94 1 666 666 CD cord-326666-melz5fq4 94 2 _SP cord-326666-melz5fq4 95 1 221 221 CD cord-326666-melz5fq4 95 2 _SP cord-326666-melz5fq4 95 3 26523 26523 CD cord-326666-melz5fq4 95 4 27191 27191 CD cord-326666-melz5fq4 96 1 669 669 CD cord-326666-melz5fq4 96 2 _SP cord-326666-melz5fq4 97 1 222 222 CD cord-326666-melz5fq4 97 2 _SP cord-326666-melz5fq4 98 1 ORF6 ORF6 NNP cord-326666-melz5fq4 98 2 _SP cord-326666-melz5fq4 99 1 ORF7 ORF7 NNP cord-326666-melz5fq4 99 2 _SP cord-326666-melz5fq4 100 1 X3 X3 NNP cord-326666-melz5fq4 100 2 _SP cord-326666-melz5fq4 101 1 27074 27074 CD cord-326666-melz5fq4 101 2 _SP cord-326666-melz5fq4 102 1 27265 27265 CD cord-326666-melz5fq4 102 2 _SP cord-326666-melz5fq4 103 1 192 192 CD cord-326666-melz5fq4 103 2 _SP cord-326666-melz5fq4 103 3 63 63 CD cord-326666-melz5fq4 103 4 _SP cord-326666-melz5fq4 103 5 27202 27202 CD cord-326666-melz5fq4 104 1 27387 27387 CD cord-326666-melz5fq4 104 2 186 186 CD cord-326666-melz5fq4 104 3 _SP cord-326666-melz5fq4 105 1 61 61 CD cord-326666-melz5fq4 105 2 _SP cord-326666-melz5fq4 106 1 ORF7a ORF7a NNP cord-326666-melz5fq4 106 2 _SP cord-326666-melz5fq4 107 1 ORF8 ORF8 NNP cord-326666-melz5fq4 107 2 _SP cord-326666-melz5fq4 107 3 X4 X4 NNP cord-326666-melz5fq4 107 4 _SP cord-326666-melz5fq4 108 1 27273 27273 CD cord-326666-melz5fq4 108 2 _SP cord-326666-melz5fq4 109 1 27641 27641 CD cord-326666-melz5fq4 109 2 _SP cord-326666-melz5fq4 110 1 369 369 CD cord-326666-melz5fq4 110 2 _SP cord-326666-melz5fq4 111 1 122 122 CD cord-326666-melz5fq4 111 2 _SP cord-326666-melz5fq4 111 3 27394 27394 CD cord-326666-melz5fq4 112 1 27759 27759 CD cord-326666-melz5fq4 112 2 decreased decrease VBD cord-326666-melz5fq4 112 3 rapidly rapidly RB cord-326666-melz5fq4 112 4 with with IN cord-326666-melz5fq4 112 5 increasing increase VBG cord-326666-melz5fq4 112 6 HGS HGS NNP cord-326666-melz5fq4 112 7 ( ( -LRB- cord-326666-melz5fq4 112 8 Fig Fig NNP cord-326666-melz5fq4 112 9 6 6 CD cord-326666-melz5fq4 112 10 ) ) -RRB- cord-326666-melz5fq4 112 11 , , , cord-326666-melz5fq4 112 12 which which WDT cord-326666-melz5fq4 112 13 provided provide VBD cord-326666-melz5fq4 112 14 evidence evidence NN cord-326666-melz5fq4 112 15 that that IN cord-326666-melz5fq4 112 16 there there EX cord-326666-melz5fq4 112 17 was be VBD cord-326666-melz5fq4 112 18 a a DT cord-326666-melz5fq4 112 19 power power NN cord-326666-melz5fq4 112 20 law law NN cord-326666-melz5fq4 112 21 _SP cord-326666-melz5fq4 113 1 Of of IN cord-326666-melz5fq4 113 2 all all PDT cord-326666-melz5fq4 113 3 the the DT cord-326666-melz5fq4 113 4 gene gene NN cord-326666-melz5fq4 113 5 mutations mutation NNS cord-326666-melz5fq4 113 6 , , , cord-326666-melz5fq4 113 7 the the DT cord-326666-melz5fq4 113 8 ORF1ab ORF1ab NNP cord-326666-melz5fq4 113 9 10818 10818 CD cord-326666-melz5fq4 113 10 G g NN cord-326666-melz5fq4 113 11 > > XX cord-326666-melz5fq4 114 1 T(TTG T(TTG NFP cord-326666-melz5fq4 114 2 > > XX cord-326666-melz5fq4 114 3 TTT TTT NNP cord-326666-melz5fq4 114 4 ) ) -RRB- cord-326666-melz5fq4 114 5 mutation mutation NN cord-326666-melz5fq4 114 6 is be VBZ cord-326666-melz5fq4 114 7 the the DT cord-326666-melz5fq4 114 8 most most RBS cord-326666-melz5fq4 114 9 interesting interesting JJ cord-326666-melz5fq4 114 10 . . . cord-326666-melz5fq4 115 1 This this DT cord-326666-melz5fq4 115 2 mutation mutation NN cord-326666-melz5fq4 115 3 333 333 CD cord-326666-melz5fq4 115 4 survived survive VBD cord-326666-melz5fq4 115 5 in in IN cord-326666-melz5fq4 115 6 all all DT cord-326666-melz5fq4 115 7 three three CD cord-326666-melz5fq4 115 8 regions region NNS cord-326666-melz5fq4 115 9 ( ( -LRB- cord-326666-melz5fq4 115 10 Fig Fig NNP cord-326666-melz5fq4 115 11 10 10 CD cord-326666-melz5fq4 115 12 ) ) -RRB- cord-326666-melz5fq4 115 13 . . . cord-326666-melz5fq4 116 1 In in IN cord-326666-melz5fq4 116 2 addition addition NN cord-326666-melz5fq4 116 3 , , , cord-326666-melz5fq4 116 4 this this DT cord-326666-melz5fq4 116 5 mutation mutation NN cord-326666-melz5fq4 116 6 occurred occur VBD cord-326666-melz5fq4 116 7 only only RB cord-326666-melz5fq4 116 8 in in IN cord-326666-melz5fq4 116 9 the the DT cord-326666-melz5fq4 116 10 high high JJ cord-326666-melz5fq4 116 11 HGS HGS NNP cord-326666-melz5fq4 116 12 population population NN cord-326666-melz5fq4 116 13 334 334 CD cord-326666-melz5fq4 116 14 rather rather RB cord-326666-melz5fq4 116 15 than than IN cord-326666-melz5fq4 116 16 in in IN cord-326666-melz5fq4 116 17 that that DT cord-326666-melz5fq4 116 18 with with IN cord-326666-melz5fq4 116 19 a a DT cord-326666-melz5fq4 116 20 lower low JJR cord-326666-melz5fq4 116 21 HGS hgs NN cord-326666-melz5fq4 116 22 ( ( -LRB- cord-326666-melz5fq4 116 23 . . . cord-326666-melz5fq4 117 1 This this DT cord-326666-melz5fq4 117 2 10818 10818 CD cord-326666-melz5fq4 117 3 G g NN cord-326666-melz5fq4 118 1 > > XX cord-326666-melz5fq4 119 1 T T NNP cord-326666-melz5fq4 119 2 ORF1ab ORF1ab NNP cord-326666-melz5fq4 119 3 mutation mutation NN cord-326666-melz5fq4 119 4 caused cause VBD cord-326666-melz5fq4 119 5 an an DT cord-326666-melz5fq4 119 6 amino amino NN cord-326666-melz5fq4 119 7 acid acid NN cord-326666-melz5fq4 119 8 mutation mutation NN cord-326666-melz5fq4 119 9 , , , cord-326666-melz5fq4 119 10 M37F M37F NNP cord-326666-melz5fq4 119 11 , , , cord-326666-melz5fq4 119 12 in in IN cord-326666-melz5fq4 119 13 the the DT cord-326666-melz5fq4 119 14 nonstructural nonstructural JJ cord-326666-melz5fq4 119 15 358 358 CD cord-326666-melz5fq4 119 16 protein protein NN cord-326666-melz5fq4 119 17 nsp6 nsp6 NN cord-326666-melz5fq4 119 18 , , , cord-326666-melz5fq4 119 19 which which WDT cord-326666-melz5fq4 119 20 is be VBZ cord-326666-melz5fq4 119 21 located locate VBN cord-326666-melz5fq4 119 22 in in IN cord-326666-melz5fq4 119 23 a a DT cord-326666-melz5fq4 119 24 loop loop NN cord-326666-melz5fq4 119 25 between between IN cord-326666-melz5fq4 119 26 the the DT cord-326666-melz5fq4 119 27 first first JJ cord-326666-melz5fq4 119 28 and and CC cord-326666-melz5fq4 119 29 second second JJ cord-326666-melz5fq4 119 30 transmembrane transmembrane NN cord-326666-melz5fq4 119 31 domains domain NNS cord-326666-melz5fq4 119 32 on on IN cord-326666-melz5fq4 119 33 the the DT cord-326666-melz5fq4 119 34 N-359 n-359 NN cord-326666-melz5fq4 119 35 terminal terminal JJ cord-326666-melz5fq4 119 36 side side NN cord-326666-melz5fq4 119 37 ( ( -LRB- cord-326666-melz5fq4 119 38 Fig Fig NNP cord-326666-melz5fq4 119 39 11 11 CD cord-326666-melz5fq4 119 40 ) ) -RRB- cord-326666-melz5fq4 119 41 . . . cord-326666-melz5fq4 120 1 This this DT cord-326666-melz5fq4 120 2 finding finding NN cord-326666-melz5fq4 120 3 strongly strongly RB cord-326666-melz5fq4 120 4 suggested suggest VBD cord-326666-melz5fq4 120 5 that that IN cord-326666-melz5fq4 120 6 the the DT cord-326666-melz5fq4 120 7 10818 10818 CD cord-326666-melz5fq4 120 8 G g NN cord-326666-melz5fq4 121 1 > > XX cord-326666-melz5fq4 122 1 T T NNP cord-326666-melz5fq4 122 2 ( ( -LRB- cord-326666-melz5fq4 122 3 M37F M37F NNP cord-326666-melz5fq4 122 4 ) ) -RRB- cord-326666-melz5fq4 122 5 mutation mutation NN cord-326666-melz5fq4 122 6 survived survive VBD cord-326666-melz5fq4 122 7 a a DT cord-326666-melz5fq4 122 8 _SP cord-326666-melz5fq4 122 9 The the DT cord-326666-melz5fq4 122 10 discovery discovery NN cord-326666-melz5fq4 122 11 of of IN cord-326666-melz5fq4 122 12 increased increase VBN cord-326666-melz5fq4 122 13 HGS HGS NNP cord-326666-melz5fq4 122 14 of of IN cord-326666-melz5fq4 122 15 ORF ORF NNP cord-326666-melz5fq4 122 16 6 6 CD cord-326666-melz5fq4 122 17 and and CC cord-326666-melz5fq4 122 18 ORF ORF NNP cord-326666-melz5fq4 122 19 8 8 CD cord-326666-melz5fq4 122 20 provide provide VBP cord-326666-melz5fq4 122 21 a a DT cord-326666-melz5fq4 122 22 strong strong JJ cord-326666-melz5fq4 122 23 evidence evidence NN cord-326666-melz5fq4 122 24 that that IN cord-326666-melz5fq4 122 25 SARS SARS NNP cord-326666-melz5fq4 122 26 - - HYPH cord-326666-melz5fq4 122 27 COV-2 COV-2 NNP cord-326666-melz5fq4 122 28 evolved evolve VBD cord-326666-melz5fq4 122 29 406 406 CD cord-326666-melz5fq4 122 30 to to TO cord-326666-melz5fq4 122 31 be be VB cord-326666-melz5fq4 122 32 more more RBR cord-326666-melz5fq4 122 33 adaptable adaptable JJ cord-326666-melz5fq4 122 34 to to IN cord-326666-melz5fq4 122 35 humans human NNS cord-326666-melz5fq4 122 36 than than IN cord-326666-melz5fq4 122 37 SARS SARS NNP cord-326666-melz5fq4 122 38 - - HYPH cord-326666-melz5fq4 122 39 CoV. CoV. NNP cord-326666-melz5fq4 123 1 Based base VBN cord-326666-melz5fq4 123 2 on on IN cord-326666-melz5fq4 123 3 these these DT cord-326666-melz5fq4 123 4 findings finding NNS cord-326666-melz5fq4 123 5 , , , cord-326666-melz5fq4 123 6 following follow VBG cord-326666-melz5fq4 123 7 conjecture conjecture NN cord-326666-melz5fq4 123 8 is be VBZ cord-326666-melz5fq4 123 9 proposed propose VBN cord-326666-melz5fq4 123 10 407 407 CD cord-326666-melz5fq4 123 11 that that IN cord-326666-melz5fq4 123 12 the the DT cord-326666-melz5fq4 123 13 SARS SARS NNP cord-326666-melz5fq4 123 14 - - HYPH cord-326666-melz5fq4 123 15 CoV-2 CoV-2 NNP cord-326666-melz5fq4 123 16 genes gene NNS cord-326666-melz5fq4 123 17 involved involve VBN cord-326666-melz5fq4 123 18 in in IN cord-326666-melz5fq4 123 19 suppressing suppress VBG cord-326666-melz5fq4 123 20 the the DT cord-326666-melz5fq4 123 21 host host NN cord-326666-melz5fq4 123 22 's 's POS cord-326666-melz5fq4 123 23 innate innate JJ cord-326666-melz5fq4 123 24 immunity immunity NN cord-326666-melz5fq4 123 25 are be VBP cord-326666-melz5fq4 123 26 more more RBR cord-326666-melz5fq4 123 27 powerful powerful JJ cord-326666-melz5fq4 123 28 . . . cord-326666-melz5fq4 123 29 _SP cord-326666-melz5fq4 124 1 A a DT cord-326666-melz5fq4 124 2 new new JJ cord-326666-melz5fq4 124 3 coronavirus coronavirus NN cord-326666-melz5fq4 124 4 associated associate VBN cord-326666-melz5fq4 124 5 with with IN cord-326666-melz5fq4 124 6 427 427 CD cord-326666-melz5fq4 124 7 human human JJ cord-326666-melz5fq4 124 8 respiratory respiratory JJ cord-326666-melz5fq4 124 9 disease disease NN cord-326666-melz5fq4 124 10 in in IN cord-326666-melz5fq4 124 11 China China NNP cord-326666-melz5fq4 124 12 Evolution Evolution NNP cord-326666-melz5fq4 124 13 of of IN cord-326666-melz5fq4 124 14 the the DT cord-326666-melz5fq4 124 15 novel novel JJ cord-326666-melz5fq4 124 16 coronavirus coronavirus NN cord-326666-melz5fq4 124 17 from from IN cord-326666-melz5fq4 124 18 the the DT cord-326666-melz5fq4 124 19 430 430 CD cord-326666-melz5fq4 124 20 ongoing ongoing JJ cord-326666-melz5fq4 124 21 Wuhan Wuhan NNP cord-326666-melz5fq4 124 22 outbreak outbreak NN cord-326666-melz5fq4 124 23 and and CC cord-326666-melz5fq4 124 24 modeling modeling NN cord-326666-melz5fq4 124 25 of of IN cord-326666-melz5fq4 124 26 its -PRON- PRP$ cord-326666-melz5fq4 124 27 spike spike NN cord-326666-melz5fq4 124 28 protein protein NN cord-326666-melz5fq4 124 29 for for IN cord-326666-melz5fq4 124 30 risk risk NN cord-326666-melz5fq4 124 31 of of IN cord-326666-melz5fq4 124 32 human human JJ cord-326666-melz5fq4 124 33 transmission transmission NN cord-326666-melz5fq4 124 34 . . . cord-326666-melz5fq4 125 1 431 431 CD cord-326666-melz5fq4 125 2 SCIENCE science NN cord-326666-melz5fq4 126 1 CHINA CHINA NNP cord-326666-melz5fq4 126 2 Life Life NNP cord-326666-melz5fq4 126 3 Sciences Sciences NNPS cord-326666-melz5fq4 126 4 Temporal Temporal NNP cord-326666-melz5fq4 126 5 dynamics dynamic NNS cord-326666-melz5fq4 126 6 in in IN cord-326666-melz5fq4 126 7 viral viral JJ cord-326666-melz5fq4 126 8 shedding shedding NN cord-326666-melz5fq4 126 9 and and CC cord-326666-melz5fq4 126 10 433 433 CD cord-326666-melz5fq4 126 11 transmissibility transmissibility NN cord-326666-melz5fq4 126 12 of of IN cord-326666-melz5fq4 126 13 COVID-19 COVID-19 NNP cord-326666-melz5fq4 126 14 Complete complete JJ cord-326666-melz5fq4 126 15 nucleotide nucleotide JJ cord-326666-melz5fq4 126 16 sequence sequence NN cord-326666-melz5fq4 126 17 of of IN cord-326666-melz5fq4 126 18 SV40 SV40 NNP cord-326666-melz5fq4 126 19 DNA DNA NNP cord-326666-melz5fq4 127 1 The the DT cord-326666-melz5fq4 127 2 nucleotide nucleotide JJ cord-326666-melz5fq4 127 3 sequence sequence NN cord-326666-melz5fq4 127 4 of of IN cord-326666-melz5fq4 127 5 repetitive repetitive JJ cord-326666-melz5fq4 127 6 monkey monkey NN cord-326666-melz5fq4 127 7 DNA dna NN cord-326666-melz5fq4 127 8 437 437 CD cord-326666-melz5fq4 127 9 found find VBD cord-326666-melz5fq4 127 10 in in IN cord-326666-melz5fq4 127 11 defective defective JJ cord-326666-melz5fq4 127 12 simian simian JJ cord-326666-melz5fq4 127 13 virus virus NN cord-326666-melz5fq4 127 14 40 40 CD cord-326666-melz5fq4 127 15 Genome genome NN cord-326666-melz5fq4 127 16 sequence sequence NN cord-326666-melz5fq4 127 17 of of IN cord-326666-melz5fq4 127 18 a a DT cord-326666-melz5fq4 127 19 human human JJ cord-326666-melz5fq4 127 20 439 439 CD cord-326666-melz5fq4 127 21 tumorigenic tumorigenic NNP cord-326666-melz5fq4 127 22 poxvirus poxvirus NNP cord-326666-melz5fq4 127 23 : : : cord-326666-melz5fq4 127 24 prediction prediction NN cord-326666-melz5fq4 127 25 of of IN cord-326666-melz5fq4 127 26 specific specific JJ cord-326666-melz5fq4 127 27 host host NN cord-326666-melz5fq4 127 28 response response NN cord-326666-melz5fq4 127 29 - - HYPH cord-326666-melz5fq4 127 30 evasion evasion NN cord-326666-melz5fq4 127 31 genes gene NNS cord-326666-melz5fq4 127 32 Prel Prel NNP cord-326666-melz5fq4 127 33 iminary iminary JJ cord-326666-melz5fq4 127 34 study study NN cord-326666-melz5fq4 127 35 on on IN cord-326666-melz5fq4 127 36 genome genome NN cord-326666-melz5fq4 127 37 homology homology NN cord-326666-melz5fq4 127 38 of of IN cord-326666-melz5fq4 127 39 viruses virus NNS cord-326666-melz5fq4 127 40 and and CC cord-326666-melz5fq4 127 41 human human JJ cord-326666-melz5fq4 127 42 The the DT cord-326666-melz5fq4 127 43 evolution evolution NN cord-326666-melz5fq4 127 44 of of IN cord-326666-melz5fq4 127 45 large large JJ cord-326666-melz5fq4 127 46 DNA dna NN cord-326666-melz5fq4 127 47 viruses virus NNS cord-326666-melz5fq4 127 48 : : : cord-326666-melz5fq4 127 49 combining combine VBG cord-326666-melz5fq4 127 50 genomic genomic JJ cord-326666-melz5fq4 127 51 444 444 CD cord-326666-melz5fq4 127 52 information information NN cord-326666-melz5fq4 127 53 of of IN cord-326666-melz5fq4 127 54 viruses virus NNS cord-326666-melz5fq4 127 55 and and CC cord-326666-melz5fq4 127 56 their -PRON- PRP$ cord-326666-melz5fq4 127 57 hosts host NNS cord-326666-melz5fq4 127 58 Immunity immunity NN cord-326666-melz5fq4 127 59 and and CC cord-326666-melz5fq4 127 60 immunopathology immunopathology NN cord-326666-melz5fq4 127 61 to to IN cord-326666-melz5fq4 127 62 viruses virus NNS cord-326666-melz5fq4 127 63 : : : cord-326666-melz5fq4 128 1 what what WP cord-326666-melz5fq4 128 2 decides decide VBZ cord-326666-melz5fq4 128 3 the the DT cord-326666-melz5fq4 128 4 outcome outcome NN cord-326666-melz5fq4 128 5 Viral viral JJ cord-326666-melz5fq4 128 6 evasion evasion NN cord-326666-melz5fq4 128 7 of of IN cord-326666-melz5fq4 128 8 antigen antigen NN cord-326666-melz5fq4 128 9 presentation presentation NN cord-326666-melz5fq4 128 10 : : : cord-326666-melz5fq4 128 11 not not RB cord-326666-melz5fq4 128 12 just just RB cord-326666-melz5fq4 128 13 for for IN cord-326666-melz5fq4 128 14 peptides peptide NNS cord-326666-melz5fq4 128 15 anymore anymore RB cord-326666-melz5fq4 129 1 SARS SARS NNP cord-326666-melz5fq4 129 2 - - HYPH cord-326666-melz5fq4 129 3 Coronavirus Coronavirus NNP cord-326666-melz5fq4 129 4 Open Open NNP cord-326666-melz5fq4 129 5 Reading read VBG cord-326666-melz5fq4 129 6 Frame-8b Frame-8b NNP cord-326666-melz5fq4 129 7 492 492 CD cord-326666-melz5fq4 129 8 triggers trigger VBZ cord-326666-melz5fq4 129 9 intracellular intracellular JJ cord-326666-melz5fq4 129 10 stress stress NN cord-326666-melz5fq4 129 11 pathways pathway NNS cord-326666-melz5fq4 129 12 and and CC cord-326666-melz5fq4 129 13 activates activate VBZ cord-326666-melz5fq4 129 14 NLRP3 nlrp3 NN cord-326666-melz5fq4 129 15 inflammasomes inflammasomes NNP cord-326666-melz5fq4 129 16 Syndrome Syndrome NNP cord-326666-melz5fq4 129 17 ( ( -LRB- cord-326666-melz5fq4 129 18 SARS SARS NNP cord-326666-melz5fq4 129 19 ) ) -RRB- cord-326666-melz5fq4 130 1 Coronavirus Coronavirus NNP cord-326666-melz5fq4 130 2 ORF8 ORF8 NNP cord-326666-melz5fq4 130 3 Protein Protein NNP cord-326666-melz5fq4 130 4 Is be VBZ cord-326666-melz5fq4 130 5 Acquired acquire VBN cord-326666-melz5fq4 130 6 from from IN cord-326666-melz5fq4 130 7 SARS SARS NNP cord-326666-melz5fq4 130 8 - - HYPH cord-326666-melz5fq4 130 9 Related relate VBN cord-326666-melz5fq4 130 10 Coronavirus Coronavirus NNP cord-326666-melz5fq4 130 11 from from IN cord-326666-melz5fq4 130 12 496 496 CD cord-326666-melz5fq4 130 13 Greater Greater NNP cord-326666-melz5fq4 130 14 Horseshoe Horseshoe NNP cord-326666-melz5fq4 130 15 Bats Bats NNPS cord-326666-melz5fq4 130 16 through through IN cord-326666-melz5fq4 130 17 Recombination Recombination NNP cord-326666-melz5fq4 130 18 Expression Expression NNP cord-326666-melz5fq4 130 19 , , , cord-326666-melz5fq4 130 20 post post JJ cord-326666-melz5fq4 130 21 - - JJ cord-326666-melz5fq4 130 22 translational translational JJ cord-326666-melz5fq4 130 23 499 499 CD cord-326666-melz5fq4 130 24 modification modification NN cord-326666-melz5fq4 130 25 and and CC cord-326666-melz5fq4 130 26 biochemical biochemical JJ cord-326666-melz5fq4 130 27 characterization characterization NN cord-326666-melz5fq4 130 28 of of IN cord-326666-melz5fq4 130 29 proteins protein NNS cord-326666-melz5fq4 130 30 encoded encode VBN cord-326666-melz5fq4 130 31 by by IN cord-326666-melz5fq4 130 32 subgenomic subgenomic NNP cord-326666-melz5fq4 130 33 mRNA8 mRNA8 NNP cord-326666-melz5fq4 130 34 of of IN cord-326666-melz5fq4 130 35 the the DT cord-326666-melz5fq4 130 36 500 500 CD cord-326666-melz5fq4 130 37 severe severe JJ cord-326666-melz5fq4 130 38 acute acute JJ cord-326666-melz5fq4 130 39 respiratory respiratory JJ cord-326666-melz5fq4 130 40 syndrome syndrome NN cord-326666-melz5fq4 130 41 coronavirus coronavirus NN cord-326666-melz5fq4 131 1 Dysregulated Dysregulated NNP cord-326666-melz5fq4 131 2 Type Type NNP cord-326666-melz5fq4 132 1 I -PRON- PRP cord-326666-melz5fq4 133 1 Interferon interferon NN cord-326666-melz5fq4 133 2 and and CC cord-326666-melz5fq4 133 3 Inflammatory inflammatory JJ cord-326666-melz5fq4 133 4 Monocyte Monocyte NNP cord-326666-melz5fq4 133 5 - - HYPH cord-326666-melz5fq4 133 6 Macrophage Macrophage NNP cord-326666-melz5fq4 133 7 Responses response NNS cord-326666-melz5fq4 134 1 Cause cause VB cord-326666-melz5fq4 135 1 Lethal lethal JJ cord-326666-melz5fq4 135 2 506 506 CD cord-326666-melz5fq4 135 3 Pneumonia Pneumonia NNP cord-326666-melz5fq4 135 4 in in IN cord-326666-melz5fq4 135 5 SARS SARS NNP cord-326666-melz5fq4 135 6 - - HYPH cord-326666-melz5fq4 135 7 CoV CoV NNP cord-326666-melz5fq4 135 8 - - HYPH cord-326666-melz5fq4 135 9 Infected infect VBN cord-326666-melz5fq4 135 10 Mice mouse NNS cord-326666-melz5fq4 136 1 The the DT cord-326666-melz5fq4 136 2 establishment establishment NN cord-326666-melz5fq4 136 3 of of IN cord-326666-melz5fq4 136 4 reference reference NN cord-326666-melz5fq4 136 5 sequence sequence NN cord-326666-melz5fq4 136 6 508 508 CD cord-326666-melz5fq4 136 7 for for IN cord-326666-melz5fq4 136 8 SARS SARS NNP cord-326666-melz5fq4 136 9 - - HYPH cord-326666-melz5fq4 136 10 CoV-2 CoV-2 NNP cord-326666-melz5fq4 136 11 and and CC cord-326666-melz5fq4 136 12 variation variation NN cord-326666-melz5fq4 136 13 analysis analysis NN cord-326666-melz5fq4 137 1 Emerging Emerging NNP cord-326666-melz5fq4 137 2 SARS SARS NNP cord-326666-melz5fq4 138 1 -CoV-510 -CoV-510 NFP cord-326666-melz5fq4 138 2 2 2 CD cord-326666-melz5fq4 138 3 mutation mutation NN cord-326666-melz5fq4 138 4 hot hot JJ cord-326666-melz5fq4 138 5 spots spot NNS cord-326666-melz5fq4 138 6 include include VBP cord-326666-melz5fq4 138 7 a a DT cord-326666-melz5fq4 138 8 novel novel JJ cord-326666-melz5fq4 138 9 RNA rna NN cord-326666-melz5fq4 138 10 - - HYPH cord-326666-melz5fq4 138 11 dependent dependent JJ cord-326666-melz5fq4 138 12 - - HYPH cord-326666-melz5fq4 138 13 RNA rna NN cord-326666-melz5fq4 138 14 polymerase polymerase NN cord-326666-melz5fq4 138 15 variant variant NN cord-326666-melz5fq4 139 1 The the DT cord-326666-melz5fq4 139 2 single single JJ cord-326666-melz5fq4 139 3 - - HYPH cord-326666-melz5fq4 139 4 cell cell NN cord-326666-melz5fq4 139 5 RNA RNA NNP cord-326666-melz5fq4 139 6 - - HYPH cord-326666-melz5fq4 139 7 seq seq NNP cord-326666-melz5fq4 139 8 data data NN cord-326666-melz5fq4 139 9 analysis analysis NN cord-326666-melz5fq4 139 10 on on IN cord-326666-melz5fq4 139 11 the the DT cord-326666-melz5fq4 139 12 537 537 CD cord-326666-melz5fq4 139 13 receptor receptor NN cord-326666-melz5fq4 139 14 ACE2 ACE2 NNP cord-326666-melz5fq4 139 15 expression expression NN cord-326666-melz5fq4 139 16 reveals reveal VBZ cord-326666-melz5fq4 139 17 the the DT cord-326666-melz5fq4 139 18 potential potential JJ cord-326666-melz5fq4 139 19 risk risk NN cord-326666-melz5fq4 139 20 of of IN cord-326666-melz5fq4 139 21 different different JJ cord-326666-melz5fq4 139 22 human human JJ cord-326666-melz5fq4 139 23 organs organ NNS cord-326666-melz5fq4 139 24 vulnerable vulnerable JJ cord-326666-melz5fq4 139 25 to to IN cord-326666-melz5fq4 139 26 Wuhan Wuhan NNP cord-326666-melz5fq4 139 27 538 538 CD cord-326666-melz5fq4 139 28 2019-nCoV 2019-ncov CD cord-326666-melz5fq4 139 29 infection infection NN cord-326666-melz5fq4 139 30 Frontiers Frontiers NNPS cord-326666-melz5fq4 139 31 of of IN cord-326666-melz5fq4 139 32 Specific specific JJ cord-326666-melz5fq4 139 33 ACE2 ACE2 NNP cord-326666-melz5fq4 139 34 Expression expression NN cord-326666-melz5fq4 139 35 in in IN cord-326666-melz5fq4 139 36 Cholangiocytes Cholangiocytes NNP cord-326666-melz5fq4 139 37 540 540 CD cord-326666-melz5fq4 140 1 May May MD cord-326666-melz5fq4 140 2 Cause cause VB cord-326666-melz5fq4 140 3 Liver liver NN cord-326666-melz5fq4 140 4 Damage damage NN cord-326666-melz5fq4 141 1 After after IN cord-326666-melz5fq4 141 2 2019-nCoV 2019-ncov CD cord-326666-melz5fq4 141 3 Infection infection NN cord-326666-melz5fq4 141 4 Priapism Priapism NNP cord-326666-melz5fq4 141 5 in in IN cord-326666-melz5fq4 141 6 a a DT cord-326666-melz5fq4 141 7 543 543 CD cord-326666-melz5fq4 141 8 patient patient NN cord-326666-melz5fq4 141 9 with with IN cord-326666-melz5fq4 141 10 coronavirus coronavirus NN cord-326666-melz5fq4 141 11 disease disease NN cord-326666-melz5fq4 141 12 2019 2019 CD cord-326666-melz5fq4 141 13 ( ( -LRB- cord-326666-melz5fq4 141 14 COVID-19 COVID-19 NNP cord-326666-melz5fq4 141 15 ) ) -RRB- cord-326666-melz5fq4 141 16 : : : cord-326666-melz5fq4 141 17 A a DT cord-326666-melz5fq4 141 18 case case NN cord-326666-melz5fq4 141 19 report report NN cord-326666-melz5fq4 141 20 Clinical clinical JJ cord-326666-melz5fq4 141 21 characteristics characteristic NNS cord-326666-melz5fq4 141 22 of of IN cord-326666-melz5fq4 141 23 2019 2019 CD cord-326666-melz5fq4 141 24 546 546 CD cord-326666-melz5fq4 141 25 novel novel JJ cord-326666-melz5fq4 141 26 coronavirus coronavirus NN cord-326666-melz5fq4 141 27 infection infection NN cord-326666-melz5fq4 141 28 in in IN cord-326666-melz5fq4 141 29 China China NNP cord-326666-melz5fq4 142 1 SARS SARS NNP cord-326666-melz5fq4 142 2 coronavirus coronavirus NN cord-326666-melz5fq4 142 3 spike spike NN cord-326666-melz5fq4 142 4 protein protein NN cord-326666-melz5fq4 142 5 - - HYPH cord-326666-melz5fq4 142 6 induced induce VBN cord-326666-melz5fq4 142 7 innate innate JJ cord-326666-melz5fq4 142 8 immune immune JJ cord-326666-melz5fq4 142 9 549 549 CD cord-326666-melz5fq4 142 10 response response NN cord-326666-melz5fq4 142 11 occurs occur VBZ cord-326666-melz5fq4 142 12 via via IN cord-326666-melz5fq4 142 13 activation activation NN cord-326666-melz5fq4 142 14 of of IN cord-326666-melz5fq4 142 15 the the DT cord-326666-melz5fq4 142 16 NF nf NN cord-326666-melz5fq4 142 17 - - HYPH cord-326666-melz5fq4 142 18 κB κB NNP cord-326666-melz5fq4 142 19 pathway pathway NN cord-326666-melz5fq4 142 20 in in IN cord-326666-melz5fq4 142 21 human human JJ cord-326666-melz5fq4 142 22 monocyte monocyte NNP cord-326666-melz5fq4 142 23 macrophages macrophage NNS cord-326666-melz5fq4 142 24 in in IN cord-326666-melz5fq4 142 25 vitro vitro FW cord-326666-melz5fq4 142 26 Human Human NNP cord-326666-melz5fq4 142 27 Coronavirus Coronavirus NNP cord-326666-melz5fq4 142 28 : : : cord-326666-melz5fq4 142 29 Host host NN cord-326666-melz5fq4 142 30 - - HYPH cord-326666-melz5fq4 142 31 Pathogen Pathogen NNP cord-326666-melz5fq4 142 32 Interaction Interaction NNP cord-326666-melz5fq4 142 33 . . . cord-326666-melz5fq4 143 1 Annual annual JJ cord-326666-melz5fq4 143 2 review review NN cord-326666-melz5fq4 143 3 of of IN cord-326666-melz5fq4 143 4 552 552 CD cord-326666-melz5fq4 143 5 microbiology microbiology NN cord-326666-melz5fq4 144 1 Innate innate JJ cord-326666-melz5fq4 144 2 Immune immune JJ cord-326666-melz5fq4 144 3 Evasion evasion NN cord-326666-melz5fq4 144 4 by by IN cord-326666-melz5fq4 144 5 Human Human NNP cord-326666-melz5fq4 144 6 Respiratory Respiratory NNP cord-326666-melz5fq4 144 7 RNA RNA NNP cord-326666-melz5fq4 144 8 Viruses virus NNS cord-326666-melz5fq4 145 1 A a DT cord-326666-melz5fq4 145 2 molecular molecular JJ cord-326666-melz5fq4 145 3 arms arm NNS cord-326666-melz5fq4 145 4 race race NN cord-326666-melz5fq4 145 5 between between IN cord-326666-melz5fq4 145 6 host host NN cord-326666-melz5fq4 145 7 innate innate JJ cord-326666-melz5fq4 145 8 antiviral antiviral JJ cord-326666-melz5fq4 145 9 response response NN cord-326666-melz5fq4 145 10 557 557 CD cord-326666-melz5fq4 145 11 and and CC cord-326666-melz5fq4 145 12 emerging emerge VBG cord-326666-melz5fq4 145 13 human human JJ cord-326666-melz5fq4 145 14 coronaviruses coronaviruse NNS cord-326666-melz5fq4 146 1 Immune immune JJ cord-326666-melz5fq4 146 2 evasion evasion NN cord-326666-melz5fq4 146 3 of of IN cord-326666-melz5fq4 146 4 porcine porcine JJ cord-326666-melz5fq4 146 5 enteric enteric JJ cord-326666-melz5fq4 146 6 coronaviruses coronaviruse NNS cord-326666-melz5fq4 146 7 and and CC cord-326666-melz5fq4 146 8 viral viral JJ cord-326666-melz5fq4 146 9 modulation modulation NN cord-326666-melz5fq4 146 10 of of IN cord-326666-melz5fq4 146 11 560 560 CD cord-326666-melz5fq4 146 12 antiviral antiviral JJ cord-326666-melz5fq4 146 13 innate innate NN cord-326666-melz5fq4 146 14 signaling signal VBG cord-326666-melz5fq4 146 15 Saitoh Saitoh NNP cord-326666-melz5fq4 146 16 T T NNP cord-326666-melz5fq4 146 17 , , , cord-326666-melz5fq4 146 18 Akira Akira NNP cord-326666-melz5fq4 146 19 S. S. NNP cord-326666-melz5fq4 146 20 Regulation Regulation NNP cord-326666-melz5fq4 146 21 of of IN cord-326666-melz5fq4 146 22 innate innate JJ cord-326666-melz5fq4 146 23 immune immune JJ cord-326666-melz5fq4 146 24 responses response NNS cord-326666-melz5fq4 146 25 by by IN cord-326666-melz5fq4 146 26 autophagy autophagy NN cord-326666-melz5fq4 146 27 - - HYPH cord-326666-melz5fq4 146 28 related relate VBN cord-326666-melz5fq4 146 29 proteins protein NNS cord-326666-melz5fq4 146 30 Human Human NNP cord-326666-melz5fq4 146 31 Coronaviruses Coronaviruses NNPS cord-326666-melz5fq4 146 32 : : : cord-326666-melz5fq4 147 1 A a DT cord-326666-melz5fq4 147 2 Review Review NNP cord-326666-melz5fq4 147 3 of of IN cord-326666-melz5fq4 147 4 Virus Virus NNP cord-326666-melz5fq4 147 5 - - HYPH cord-326666-melz5fq4 147 6 Host host NN cord-326666-melz5fq4 147 7 Interactions interaction NNS cord-326666-melz5fq4 147 8 Viral viral JJ cord-326666-melz5fq4 147 9 Innate innate VBP cord-326666-melz5fq4 147 10 Immune immune JJ cord-326666-melz5fq4 147 11 Evasion evasion NN cord-326666-melz5fq4 147 12 and and CC cord-326666-melz5fq4 147 13 the the DT cord-326666-melz5fq4 147 14 Pathogenesis Pathogenesis NNP cord-326666-melz5fq4 147 15 of of IN cord-326666-melz5fq4 147 16 Emerging Emerging NNP cord-326666-melz5fq4 147 17 RNA RNA NNP cord-326666-melz5fq4 147 18 570 570 CD cord-326666-melz5fq4 147 19 Evasion evasion NN cord-326666-melz5fq4 147 20 of of IN cord-326666-melz5fq4 147 21 Host Host NNP cord-326666-melz5fq4 147 22 Innate Innate NNP cord-326666-melz5fq4 147 23 Immunity immunity NN cord-326666-melz5fq4 147 24 by by IN cord-326666-melz5fq4 147 25 Emerging emerge VBG cord-326666-melz5fq4 147 26 Viruses virus NNS cord-326666-melz5fq4 147 27 : : : cord-326666-melz5fq4 148 1 Antagonizing antagonize VBG cord-326666-melz5fq4 148 2 Host Host NNP cord-326666-melz5fq4 148 3 RIG rig NN cord-326666-melz5fq4 148 4 - - : cord-326666-melz5fq4 148 5 I -PRON- PRP cord-326666-melz5fq4 148 6 572 572 CD cord-326666-melz5fq4 148 7 578 578 CD cord-326666-melz5fq4 148 8 shown show VBN cord-326666-melz5fq4 148 9 with with IN cord-326666-melz5fq4 148 10 special special JJ cord-326666-melz5fq4 148 11 markers marker NNS cord-326666-melz5fq4 148 12 at at IN cord-326666-melz5fq4 148 13 the the DT cord-326666-melz5fq4 148 14 top top NN cord-326666-melz5fq4 148 15 of of IN cord-326666-melz5fq4 148 16 colored colored JJ cord-326666-melz5fq4 148 17 blocks block NNS cord-326666-melz5fq4 148 18 representing represent VBG cord-326666-melz5fq4 148 19 ORFs ORFs NNP cord-326666-melz5fq4 148 20 . . . cord-326666-melz5fq4 149 1 Mutation mutation NN cord-326666-melz5fq4 149 2 623 623 CD cord-326666-melz5fq4 150 1 10818 10818 CD cord-326666-melz5fq4 150 2 G g NN cord-326666-melz5fq4 151 1 > > XX cord-326666-melz5fq4 152 1 T T NNP cord-326666-melz5fq4 152 2 in in IN cord-326666-melz5fq4 152 3 ORF1ab ORF1ab NNP cord-326666-melz5fq4 153 1 ( ( -LRB- cord-326666-melz5fq4 153 2 codon codon NN cord-326666-melz5fq4 153 3 TTG TTG NNP cord-326666-melz5fq4 153 4 > > XX cord-326666-melz5fq4 153 5 TTT TTT NNP cord-326666-melz5fq4 153 6 ) ) -RRB- cord-326666-melz5fq4 153 7 occurred occur VBD cord-326666-melz5fq4 153 8 in in IN cord-326666-melz5fq4 153 9 populations population NNS cord-326666-melz5fq4 153 10 with with IN cord-326666-melz5fq4 153 11 high high JJ cord-326666-melz5fq4 153 12 HGS hgs NN cord-326666-melz5fq4 153 13 , , , cord-326666-melz5fq4 153 14 which which WDT cord-326666-melz5fq4 153 15 624 624 CD cord-326666-melz5fq4 153 16 results result NNS cord-326666-melz5fq4 153 17 in in IN cord-326666-melz5fq4 153 18 amino amino NN cord-326666-melz5fq4 153 19 acid acid NN cord-326666-melz5fq4 153 20 M37F m37f NN cord-326666-melz5fq4 153 21 mutation mutation NN cord-326666-melz5fq4 153 22 in in IN cord-326666-melz5fq4 153 23 transmembrane transmembrane NNP cord-326666-melz5fq4 153 24 protein protein NN cord-326666-melz5fq4 153 25 nsp6 nsp6 RB cord-326666-melz5fq4 153 26 . . . cord-326666-melz5fq4 154 1 The the DT cord-326666-melz5fq4 154 2 mutation mutation NN cord-326666-melz5fq4 154 3 rarely rarely RB cord-326666-melz5fq4 154 4 625 625 CD cord-326666-melz5fq4 154 5 Mutation mutation NN cord-326666-melz5fq4 154 6 profile profile NN cord-326666-melz5fq4 154 7 for for IN cord-326666-melz5fq4 154 8 SARS SARS NNP cord-326666-melz5fq4 154 9 - - HYPH cord-326666-melz5fq4 154 10 CoV-2 CoV-2 NNP cord-326666-melz5fq4 154 11 genomes genome NNS cord-326666-melz5fq4 154 12 ( ( -LRB- cord-326666-melz5fq4 154 13 geolocation geolocation NN cord-326666-melz5fq4 154 14 of of IN cord-326666-melz5fq4 154 15 Europe Europe NNP cord-326666-melz5fq4 154 16 ) ) -RRB- cord-326666-melz5fq4 154 17 with with IN cord-326666-melz5fq4 154 18 different different JJ cord-326666-melz5fq4 154 19 HGS HGS NNP cord-326666-melz5fq4 154 20 Out out IN cord-326666-melz5fq4 154 21 of of IN cord-326666-melz5fq4 154 22 a a DT cord-326666-melz5fq4 154 23 total total NN cord-326666-melz5fq4 154 24 of of IN cord-326666-melz5fq4 154 25 856 856 CD cord-326666-melz5fq4 154 26 viral viral JJ cord-326666-melz5fq4 154 27 genomes genome NNS cord-326666-melz5fq4 154 28 , , , cord-326666-melz5fq4 154 29 98 98 CD cord-326666-melz5fq4 154 30 genomes genome NNS cord-326666-melz5fq4 154 31 have have VBP cord-326666-melz5fq4 154 32 unique unique JJ cord-326666-melz5fq4 154 33 HGS HGS NNP cord-326666-melz5fq4 154 34 values value NNS cord-326666-melz5fq4 154 35 . . . cord-326666-melz5fq4 155 1 A a DT cord-326666-melz5fq4 155 2 total total NN cord-326666-melz5fq4 155 3 of of IN cord-326666-melz5fq4 155 4 145 145 CD cord-326666-melz5fq4 155 5 628 628 CD cord-326666-melz5fq4 155 6 mutations mutation NNS cord-326666-melz5fq4 155 7 were be VBD cord-326666-melz5fq4 155 8 identified identify VBN cord-326666-melz5fq4 155 9 in in IN cord-326666-melz5fq4 155 10 all all PDT cord-326666-melz5fq4 155 11 the the DT cord-326666-melz5fq4 155 12 genomes genome NNS cord-326666-melz5fq4 155 13 . . . cord-326666-melz5fq4 156 1 The the DT cord-326666-melz5fq4 156 2 top top JJ cord-326666-melz5fq4 156 3 7 7 CD cord-326666-melz5fq4 156 4 conserved conserved JJ cord-326666-melz5fq4 156 5 mutations mutation NNS cord-326666-melz5fq4 156 6 with with IN cord-326666-melz5fq4 156 7 were be VBD cord-326666-melz5fq4 156 8 shown show VBN cord-326666-melz5fq4 156 9 629 629 CD cord-326666-melz5fq4 156 10 with with IN cord-326666-melz5fq4 156 11 special special JJ cord-326666-melz5fq4 156 12 markers marker NNS cord-326666-melz5fq4 156 13 at at IN cord-326666-melz5fq4 156 14 the the DT cord-326666-melz5fq4 156 15 top top NN cord-326666-melz5fq4 156 16 of of IN cord-326666-melz5fq4 156 17 colored colored JJ cord-326666-melz5fq4 156 18 blocks block NNS cord-326666-melz5fq4 156 19 representing represent VBG cord-326666-melz5fq4 156 20 ORFs ORFs NNP cord-326666-melz5fq4 156 21 . . . cord-326666-melz5fq4 157 1 Mutation mutation NN cord-326666-melz5fq4 157 2 ORF1ab ORF1ab NNP cord-326666-melz5fq4 158 1 ( ( -LRB- cord-326666-melz5fq4 158 2 codon codon NN cord-326666-melz5fq4 158 3 TTG TTG NNP cord-326666-melz5fq4 158 4 > > XX cord-326666-melz5fq4 158 5 TTT TTT NNP cord-326666-melz5fq4 158 6 ) ) -RRB- cord-326666-melz5fq4 158 7 occurred occur VBD cord-326666-melz5fq4 158 8 in in IN cord-326666-melz5fq4 158 9 populations population NNS cord-326666-melz5fq4 158 10 with with IN cord-326666-melz5fq4 158 11 high high JJ cord-326666-melz5fq4 158 12 HGS hgs NN cord-326666-melz5fq4 158 13 , , , cord-326666-melz5fq4 158 14 which which WDT cord-326666-melz5fq4 158 15 results result VBZ cord-326666-melz5fq4 158 16 in in IN cord-326666-melz5fq4 158 17 amino amino NN cord-326666-melz5fq4 158 18 631 631 CD cord-326666-melz5fq4 158 19 acid acid NN cord-326666-melz5fq4 158 20 M37F m37f NN cord-326666-melz5fq4 158 21 mutation mutation NN cord-326666-melz5fq4 158 22 in in IN cord-326666-melz5fq4 158 23 transmembrane transmembrane NNP cord-326666-melz5fq4 158 24 protein protein NN cord-326666-melz5fq4 158 25 nsp6 nsp6 RB cord-326666-melz5fq4 158 26 . . . cord-326666-melz5fq4 159 1 The the DT cord-326666-melz5fq4 159 2 mutation mutation NN cord-326666-melz5fq4 159 3 rarely rarely RB cord-326666-melz5fq4 159 4 occurred occur VBD cord-326666-melz5fq4 159 5 in in IN cord-326666-melz5fq4 159 6 632 632 CD cord-326666-melz5fq4 159 7 populations population NNS cord-326666-melz5fq4 159 8 with with IN cord-326666-melz5fq4 159 9 low low JJ cord-326666-melz5fq4 159 10 / / SYM cord-326666-melz5fq4 159 11 moderate moderate JJ cord-326666-melz5fq4 159 12 HGS HGS NNP cord-326666-melz5fq4 159 13 Highly highly RB cord-326666-melz5fq4 159 14 conserved conserve VBN cord-326666-melz5fq4 159 15 mutations mutation NNS cord-326666-melz5fq4 159 16 identified identify VBN cord-326666-melz5fq4 159 17 in in IN cord-326666-melz5fq4 159 18 SARS SARS NNP cord-326666-melz5fq4 159 19 - - HYPH cord-326666-melz5fq4 159 20 CoV-2 CoV-2 NNP cord-326666-melz5fq4 159 21 genomes genome NNS cord-326666-melz5fq4 159 22 with with IN cord-326666-melz5fq4 159 23 geolocations geolocation NNS cord-326666-melz5fq4 159 24 of of IN cord-326666-melz5fq4 159 25 634 634 CD cord-326666-melz5fq4 159 26 The the DT cord-326666-melz5fq4 159 27 three three CD cord-326666-melz5fq4 159 28 regions region NNS cord-326666-melz5fq4 159 29 have have VBP cord-326666-melz5fq4 159 30 different different JJ cord-326666-melz5fq4 159 31 sets set NNS cord-326666-melz5fq4 159 32 of of IN cord-326666-melz5fq4 159 33 mutations mutation NNS cord-326666-melz5fq4 159 34 . . . cord-326666-melz5fq4 160 1 The the DT cord-326666-melz5fq4 160 2 TTT TTT NNP cord-326666-melz5fq4 160 3 ( ( -LRB- cord-326666-melz5fq4 160 4 F F NNP cord-326666-melz5fq4 160 5 Phenylalanine Phenylalanine NNP cord-326666-melz5fq4 160 6 ) ) -RRB- cord-326666-melz5fq4 160 7 mutation mutation NN cord-326666-melz5fq4 160 8 occurred occur VBD cord-326666-melz5fq4 160 9 in in IN cord-326666-melz5fq4 160 10 all all DT cord-326666-melz5fq4 160 11 three three CD cord-326666-melz5fq4 160 12 regions region NNS cord-326666-melz5fq4 160 13 . . . cord-326666-melz5fq4 161 1 TTT TTT NNP cord-326666-melz5fq4 161 2 represents represent VBZ cord-326666-melz5fq4 161 3 the the DT cord-326666-melz5fq4 161 4 mutation mutation NN cord-326666-melz5fq4 161 5 636 636 CD cord-326666-melz5fq4 161 6 10818 10818 CD cord-326666-melz5fq4 161 7 G g NN cord-326666-melz5fq4 162 1 > > XX cord-326666-melz5fq4 163 1 T(TTG T(TTG NFP cord-326666-melz5fq4 163 2 > > XX cord-326666-melz5fq4 163 3 TTT TTT NNP cord-326666-melz5fq4 163 4 ) ) -RRB- cord-326666-melz5fq4 163 5 in in IN cord-326666-melz5fq4 163 6 ORF1ab ORF1ab NNP cord-326666-melz5fq4 163 7 . . . cord-326666-melz5fq4 164 1 The the DT cord-326666-melz5fq4 164 2 F F NNP cord-326666-melz5fq4 164 3 in in IN cord-326666-melz5fq4 164 4 the the DT cord-326666-melz5fq4 164 5 circle circle NN cord-326666-melz5fq4 164 6 represents represent VBZ cord-326666-melz5fq4 164 7 the the DT cord-326666-melz5fq4 164 8 amino amino NN cord-326666-melz5fq4 164 9 acid acid NN cord-326666-melz5fq4 164 10 mutation mutation NN cord-326666-melz5fq4 164 11 637 637 CD cord-326666-melz5fq4 164 12 Methionine methionine NN cord-326666-melz5fq4 164 13 to to IN cord-326666-melz5fq4 164 14 Phenylalanine Phenylalanine NNP cord-326666-melz5fq4 164 15 ) ) -RRB- cord-326666-melz5fq4 164 16 in in IN cord-326666-melz5fq4 164 17 nonstructural nonstructural JJ cord-326666-melz5fq4 164 18 protein protein NN cord-326666-melz5fq4 164 19 nsp6 nsp6 NNP cord-326666-melz5fq4 164 20 . . . cord-326666-melz5fq4 165 1 The the DT cord-326666-melz5fq4 165 2 P p NN cord-326666-melz5fq4 165 3 , , , cord-326666-melz5fq4 165 4 H h NN cord-326666-melz5fq4 165 5 , , , cord-326666-melz5fq4 166 1 + + CC cord-326666-melz5fq4 166 2 , , , cord-326666-melz5fq4 166 3 -and -and : cord-326666-melz5fq4 166 4 S s NN cord-326666-melz5fq4 166 5 in in IN cord-326666-melz5fq4 166 6 638 638 CD cord-326666-melz5fq4 166 7 brackets bracket NNS cord-326666-melz5fq4 166 8 in in IN cord-326666-melz5fq4 166 9 the the DT cord-326666-melz5fq4 166 10 legend legend NN cord-326666-melz5fq4 166 11 represent represent VBP cord-326666-melz5fq4 166 12 polar polar JJ cord-326666-melz5fq4 166 13 , , , cord-326666-melz5fq4 166 14 hydrophobic hydrophobic JJ cord-326666-melz5fq4 166 15 , , , cord-326666-melz5fq4 166 16 positively positively RB cord-326666-melz5fq4 166 17 charged charge VBN cord-326666-melz5fq4 166 18 , , , cord-326666-melz5fq4 166 19 negatively negatively RB cord-326666-melz5fq4 166 20 charged charge VBD cord-326666-melz5fq4 166 21 639 639 CD cord-326666-melz5fq4 166 22 and and CC cord-326666-melz5fq4 166 23 special special JJ cord-326666-melz5fq4 166 24 residues residue NNS cord-326666-melz5fq4 167 1 The the DT cord-326666-melz5fq4 167 2 topology topology NN cord-326666-melz5fq4 167 3 of of IN cord-326666-melz5fq4 167 4 transmembrane transmembrane NNP cord-326666-melz5fq4 167 5 protein protein NN cord-326666-melz5fq4 167 6 nsp6 nsp6 NN cord-326666-melz5fq4 167 7 and and CC cord-326666-melz5fq4 167 8 the the DT cord-326666-melz5fq4 167 9 identified identify VBN cord-326666-melz5fq4 167 10 M37F m37f NN cord-326666-melz5fq4 167 11 mutation mutation NN cord-326666-melz5fq4 167 12 641 641 CD cord-326666-melz5fq4 167 13 located locate VBN cord-326666-melz5fq4 167 14 in in IN cord-326666-melz5fq4 167 15 a a DT cord-326666-melz5fq4 167 16 loop loop NN cord-326666-melz5fq4 167 17 between between IN cord-326666-melz5fq4 167 18 the the DT cord-326666-melz5fq4 167 19 first first JJ cord-326666-melz5fq4 167 20 and and CC cord-326666-melz5fq4 167 21 second second JJ cord-326666-melz5fq4 167 22 The the DT cord-326666-melz5fq4 167 23 accession accession NN cord-326666-melz5fq4 167 24 number number NN cord-326666-melz5fq4 167 25 and and CC cord-326666-melz5fq4 167 26 corresponding correspond VBG cord-326666-melz5fq4 167 27 HGS HGS NNP cord-326666-melz5fq4 167 28 of of IN cord-326666-melz5fq4 167 29 200 200 CD cord-326666-melz5fq4 167 30 SARS SARS NNP cord-326666-melz5fq4 167 31 - - HYPH cord-326666-melz5fq4 167 32 CoV-2 CoV-2 NNP cord-326666-melz5fq4 167 33 646 646 CD cord-326666-melz5fq4 167 34 genomes genome NNS cord-326666-melz5fq4 167 35 with with IN cord-326666-melz5fq4 167 36 geolocation geolocation NN cord-326666-melz5fq4 167 37 of of IN cord-326666-melz5fq4 167 38 China China NNP cord-326666-melz5fq4 167 39 . . . cord-326666-melz5fq4 168 1 Filename Filename NNP cord-326666-melz5fq4 168 2 is be VBZ cord-326666-melz5fq4 168 3 DatasetS1_China_SARS DatasetS1_China_SARS NNPS cord-326666-melz5fq4 168 4 - - : cord-326666-melz5fq4 168 5 CoV-647 CoV-647 NNP cord-326666-melz5fq4 168 6 2_nstrain200_ORFHGS_allinone.xls 2_nstrain200_orfhgs_allinone.xls CD cord-326666-melz5fq4 168 7 . . . cord-326666-melz5fq4 169 1 The the DT cord-326666-melz5fq4 169 2 file file NN cord-326666-melz5fq4 169 3 contains contain VBZ cord-326666-melz5fq4 169 4 accession accession NN cord-326666-melz5fq4 169 5 ID ID NNP cord-326666-melz5fq4 169 6 , , , cord-326666-melz5fq4 169 7 collection collection NN cord-326666-melz5fq4 169 8 date date NN cord-326666-melz5fq4 169 9 , , , cord-326666-melz5fq4 169 10 location location NN cord-326666-melz5fq4 169 11 , , , cord-326666-melz5fq4 169 12 648 648 CD cord-326666-melz5fq4 169 13 HGS HGS NNP cord-326666-melz5fq4 169 14 values value NNS cord-326666-melz5fq4 169 15 for for IN cord-326666-melz5fq4 169 16 10 10 CD cord-326666-melz5fq4 169 17 ORFs orfs NN cord-326666-melz5fq4 170 1 The the DT cord-326666-melz5fq4 170 2 accession accession NN cord-326666-melz5fq4 170 3 number number NN cord-326666-melz5fq4 170 4 and and CC cord-326666-melz5fq4 170 5 corresponding correspond VBG cord-326666-melz5fq4 170 6 HGS HGS NNP cord-326666-melz5fq4 170 7 of of IN cord-326666-melz5fq4 170 8 1538 1538 CD cord-326666-melz5fq4 170 9 SARS SARS NNP cord-326666-melz5fq4 170 10 - - HYPH cord-326666-melz5fq4 170 11 CoV-2 CoV-2 NNP cord-326666-melz5fq4 170 12 651 651 CD cord-326666-melz5fq4 170 13 genomes genome NNS cord-326666-melz5fq4 170 14 with with IN cord-326666-melz5fq4 170 15 geolocation geolocation NN cord-326666-melz5fq4 170 16 of of IN cord-326666-melz5fq4 170 17 the the DT cord-326666-melz5fq4 170 18 USA USA NNP cord-326666-melz5fq4 170 19 . . . cord-326666-melz5fq4 171 1 Filename filename NN cord-326666-melz5fq4 171 2 is be VBZ cord-326666-melz5fq4 171 3 DatasetS2_USA_SARS DatasetS2_USA_SARS NNP cord-326666-melz5fq4 171 4 - - HYPH cord-326666-melz5fq4 171 5 CoV-652 CoV-652 NNP cord-326666-melz5fq4 171 6 2_nstrain1538_ORFHGS_allinone.xls 2_nstrain1538_orfhgs_allinone.xls CD cord-326666-melz5fq4 171 7 . . . cord-326666-melz5fq4 172 1 The the DT cord-326666-melz5fq4 172 2 file file NN cord-326666-melz5fq4 172 3 contains contain VBZ cord-326666-melz5fq4 172 4 accession accession NN cord-326666-melz5fq4 172 5 ID ID NNP cord-326666-melz5fq4 172 6 , , , cord-326666-melz5fq4 172 7 collection collection NN cord-326666-melz5fq4 172 8 date date NN cord-326666-melz5fq4 172 9 , , , cord-326666-melz5fq4 172 10 location location NN cord-326666-melz5fq4 172 11 , , , cord-326666-melz5fq4 172 12 653 653 CD cord-326666-melz5fq4 172 13 HGS HGS NNP cord-326666-melz5fq4 172 14 values value NNS cord-326666-melz5fq4 172 15 for for IN cord-326666-melz5fq4 172 16 10 10 CD cord-326666-melz5fq4 172 17 ORFs orfs NN cord-326666-melz5fq4 173 1 The the DT cord-326666-melz5fq4 173 2 accession accession NN cord-326666-melz5fq4 173 3 number number NN cord-326666-melz5fq4 173 4 and and CC cord-326666-melz5fq4 173 5 corresponding correspond VBG cord-326666-melz5fq4 173 6 HGS HGS NNP cord-326666-melz5fq4 173 7 of of IN cord-326666-melz5fq4 173 8 856 856 CD cord-326666-melz5fq4 173 9 SARS SARS NNP cord-326666-melz5fq4 173 10 - - HYPH cord-326666-melz5fq4 173 11 CoV-2 CoV-2 NNP cord-326666-melz5fq4 173 12 656 656 CD cord-326666-melz5fq4 173 13 genomes genome NNS cord-326666-melz5fq4 173 14 with with IN cord-326666-melz5fq4 173 15 geolocation geolocation NN cord-326666-melz5fq4 173 16 of of IN cord-326666-melz5fq4 173 17 Europe Europe NNP cord-326666-melz5fq4 173 18 . . . cord-326666-melz5fq4 174 1 Filename filename NN cord-326666-melz5fq4 174 2 is be VBZ cord-326666-melz5fq4 174 3 DatasetS3_Europe_SARS datasets3_europe_sars NN cord-326666-melz5fq4 174 4 - - HYPH cord-326666-melz5fq4 174 5 CoV-657 CoV-657 NNP cord-326666-melz5fq4 174 6 2_nstrain856_ORFHGS_allinone.xls 2_nstrain856_orfhgs_allinone.xls CD cord-326666-melz5fq4 174 7 . . . cord-326666-melz5fq4 175 1 The the DT cord-326666-melz5fq4 175 2 file file NN cord-326666-melz5fq4 175 3 contains contain VBZ cord-326666-melz5fq4 175 4 accession accession NN cord-326666-melz5fq4 175 5 ID ID NNP cord-326666-melz5fq4 175 6 , , , cord-326666-melz5fq4 175 7 collection collection NN cord-326666-melz5fq4 175 8 date date NN cord-326666-melz5fq4 175 9 , , , cord-326666-melz5fq4 175 10 location location NN cord-326666-melz5fq4 175 11 , , , cord-326666-melz5fq4 175 12 658 658 CD cord-326666-melz5fq4 175 13 HGS HGS NNP cord-326666-melz5fq4 175 14 values value NNS cord-326666-melz5fq4 175 15 for for IN cord-326666-melz5fq4 175 16 10 10 CD cord-326666-melz5fq4 175 17 ORFs orfs NN cord-326666-melz5fq4 176 1 The the DT cord-326666-melz5fq4 176 2 accession accession NN cord-326666-melz5fq4 176 3 number number NN cord-326666-melz5fq4 176 4 and and CC cord-326666-melz5fq4 176 5 corresponding correspond VBG cord-326666-melz5fq4 176 6 HGS HGS NNP cord-326666-melz5fq4 176 7 of of IN cord-326666-melz5fq4 176 8 25 25 CD cord-326666-melz5fq4 176 9 SARS SARS NNP cord-326666-melz5fq4 176 10 - - HYPH cord-326666-melz5fq4 176 11 CoV CoV NNP cord-326666-melz5fq4 176 12 661 661 CD cord-326666-melz5fq4 176 13 genomes genome NNS cord-326666-melz5fq4 176 14 . . . cord-326666-melz5fq4 177 1 Filename filename NN cord-326666-melz5fq4 177 2 is be VBZ cord-326666-melz5fq4 177 3 DatasetS4_SARS-CoV_nstrain25_ORFHGS_allinone.xls DatasetS4_SARS-CoV_nstrain25_ORFHGS_allinone.xls NNP cord-326666-melz5fq4 177 4 . . . cord-326666-melz5fq4 178 1 The the DT cord-326666-melz5fq4 178 2 file file NN cord-326666-melz5fq4 178 3 662 662 CD cord-326666-melz5fq4 178 4 contains contain VBZ cord-326666-melz5fq4 178 5 accession accession NN cord-326666-melz5fq4 178 6 ID ID NNP cord-326666-melz5fq4 178 7 , , , cord-326666-melz5fq4 178 8 HGS HGS NNP cord-326666-melz5fq4 178 9 values value NNS cord-326666-melz5fq4 178 10 for for IN cord-326666-melz5fq4 178 11 10 10 CD cord-326666-melz5fq4 178 12 ORFs orfs NN cord-326666-melz5fq4 178 13 the the DT cord-326666-melz5fq4 178 14 weighted weighted JJ cord-326666-melz5fq4 178 15 HGS HGS NNP cord-326666-melz5fq4 178 16 of of IN cord-326666-melz5fq4 178 17 the the DT cord-326666-melz5fq4 178 18 whole whole JJ cord-326666-melz5fq4 178 19 genome genome NN