id	sid	tid	token	lemma	pos
cord-326257-rcv8sh22	1	1	key	key	JJ
cord-326257-rcv8sh22	2	1	:	:	:
cord-326257-rcv8sh22	2	2	cord-326257-rcv8sh22	cord-326257-rcv8sh22	NNP
cord-326257-rcv8sh22	2	3	authors	author	NNS
cord-326257-rcv8sh22	2	4	:	:	:
cord-326257-rcv8sh22	2	5	Simmonds	Simmonds	NNP
cord-326257-rcv8sh22	2	6	,	,	,
cord-326257-rcv8sh22	2	7	P.	P.	NNP
cord-326257-rcv8sh22	2	8	title	title	NN
cord-326257-rcv8sh22	2	9	:	:	:
cord-326257-rcv8sh22	3	1	Rampant	rampant	JJ
cord-326257-rcv8sh22	3	2	C->U	C->U	NNP
cord-326257-rcv8sh22	3	3	hypermutation	hypermutation	NN
cord-326257-rcv8sh22	3	4	in	in	IN
cord-326257-rcv8sh22	3	5	the	the	DT
cord-326257-rcv8sh22	3	6	genomes	genome	NNS
cord-326257-rcv8sh22	3	7	of	of	IN
cord-326257-rcv8sh22	3	8	SARS	SARS	NNP
cord-326257-rcv8sh22	3	9	-	-	HYPH
cord-326257-rcv8sh22	3	10	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	3	11	and	and	CC
cord-326257-rcv8sh22	3	12	other	other	JJ
cord-326257-rcv8sh22	3	13	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	3	14	–	–	:
cord-326257-rcv8sh22	3	15	causes	cause	NNS
cord-326257-rcv8sh22	3	16	and	and	CC
cord-326257-rcv8sh22	3	17	consequences	consequence	NNS
cord-326257-rcv8sh22	3	18	for	for	IN
cord-326257-rcv8sh22	3	19	their	-PRON-	PRP$
cord-326257-rcv8sh22	3	20	short	short	JJ
cord-326257-rcv8sh22	3	21	and	and	CC
cord-326257-rcv8sh22	3	22	long	long	JJ
cord-326257-rcv8sh22	3	23	evolutionary	evolutionary	JJ
cord-326257-rcv8sh22	3	24	trajectories	trajectory	NNS
cord-326257-rcv8sh22	3	25	date	date	NN
cord-326257-rcv8sh22	3	26	:	:	:
cord-326257-rcv8sh22	3	27	2020	2020	CD
cord-326257-rcv8sh22	3	28	-	-	HYPH
cord-326257-rcv8sh22	3	29	05	05	CD
cord-326257-rcv8sh22	3	30	-	-	HYPH
cord-326257-rcv8sh22	3	31	01	01	CD
cord-326257-rcv8sh22	3	32	journal	journal	NN
cord-326257-rcv8sh22	3	33	:	:	:
cord-326257-rcv8sh22	4	1	bioRxiv	biorxiv	IN
cord-326257-rcv8sh22	4	2	DOI	DOI	NNP
cord-326257-rcv8sh22	4	3	:	:	:
cord-326257-rcv8sh22	5	1	10.1101/2020.05.01.072330	10.1101/2020.05.01.072330	CD
cord-326257-rcv8sh22	5	2	sha	sha	NNP
cord-326257-rcv8sh22	5	3	:	:	:
cord-326257-rcv8sh22	6	1	aa4b611459fea6a90924158afbf35ce258a5533a	aa4b611459fea6a90924158afbf35ce258a5533a	NNP
cord-326257-rcv8sh22	6	2	doc_id	doc_id	NNPS
cord-326257-rcv8sh22	6	3	:	:	:
cord-326257-rcv8sh22	6	4	326257	326257	CD
cord-326257-rcv8sh22	6	5	cord_uid	cord_uid	NNS
cord-326257-rcv8sh22	6	6	:	:	:
cord-326257-rcv8sh22	6	7	rcv8sh22	rcv8sh22	NNP
cord-326257-rcv8sh22	7	1	The	the	DT
cord-326257-rcv8sh22	7	2	pandemic	pandemic	NN
cord-326257-rcv8sh22	7	3	of	of	IN
cord-326257-rcv8sh22	7	4	SARS	SARS	NNP
cord-326257-rcv8sh22	7	5	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	7	6	2	2	CD
cord-326257-rcv8sh22	7	7	(	(	-LRB-
cord-326257-rcv8sh22	7	8	SARS	SARS	NNP
cord-326257-rcv8sh22	7	9	-	-	HYPH
cord-326257-rcv8sh22	7	10	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	7	11	)	)	-RRB-
cord-326257-rcv8sh22	7	12	has	have	VBZ
cord-326257-rcv8sh22	7	13	motivated	motivate	VBN
cord-326257-rcv8sh22	7	14	an	an	DT
cord-326257-rcv8sh22	7	15	intensive	intensive	JJ
cord-326257-rcv8sh22	7	16	analysis	analysis	NN
cord-326257-rcv8sh22	7	17	of	of	IN
cord-326257-rcv8sh22	7	18	its	-PRON-	PRP$
cord-326257-rcv8sh22	7	19	molecular	molecular	JJ
cord-326257-rcv8sh22	7	20	epidemiology	epidemiology	NN
cord-326257-rcv8sh22	7	21	following	follow	VBG
cord-326257-rcv8sh22	7	22	its	-PRON-	PRP$
cord-326257-rcv8sh22	7	23	worldwide	worldwide	JJ
cord-326257-rcv8sh22	7	24	spread	spread	NN
cord-326257-rcv8sh22	7	25	.	.	.
cord-326257-rcv8sh22	8	1	To	to	TO
cord-326257-rcv8sh22	8	2	understand	understand	VB
cord-326257-rcv8sh22	8	3	the	the	DT
cord-326257-rcv8sh22	8	4	early	early	JJ
cord-326257-rcv8sh22	8	5	evolutionary	evolutionary	JJ
cord-326257-rcv8sh22	8	6	events	event	NNS
cord-326257-rcv8sh22	8	7	following	follow	VBG
cord-326257-rcv8sh22	8	8	its	-PRON-	PRP$
cord-326257-rcv8sh22	8	9	emergence	emergence	NN
cord-326257-rcv8sh22	8	10	,	,	,
cord-326257-rcv8sh22	8	11	a	a	DT
cord-326257-rcv8sh22	8	12	dataset	dataset	NN
cord-326257-rcv8sh22	8	13	of	of	IN
cord-326257-rcv8sh22	8	14	985	985	CD
cord-326257-rcv8sh22	8	15	complete	complete	JJ
cord-326257-rcv8sh22	8	16	SARS	SARS	NNP
cord-326257-rcv8sh22	8	17	-	-	HYPH
cord-326257-rcv8sh22	8	18	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	8	19	sequences	sequence	NNS
cord-326257-rcv8sh22	8	20	was	be	VBD
cord-326257-rcv8sh22	8	21	assembled	assemble	VBN
cord-326257-rcv8sh22	8	22	.	.	.
cord-326257-rcv8sh22	9	1	Variants	variant	NNS
cord-326257-rcv8sh22	9	2	showed	show	VBD
cord-326257-rcv8sh22	9	3	a	a	DT
cord-326257-rcv8sh22	9	4	mean	mean	JJ
cord-326257-rcv8sh22	9	5	5.5	5.5	CD
cord-326257-rcv8sh22	9	6	-	-	SYM
cord-326257-rcv8sh22	9	7	9.5	9.5	CD
cord-326257-rcv8sh22	9	8	nucleotide	nucleotide	JJ
cord-326257-rcv8sh22	9	9	differences	difference	NNS
cord-326257-rcv8sh22	9	10	from	from	IN
cord-326257-rcv8sh22	9	11	each	each	DT
cord-326257-rcv8sh22	9	12	other	other	JJ
cord-326257-rcv8sh22	9	13	,	,	,
cord-326257-rcv8sh22	9	14	commensurate	commensurate	JJ
cord-326257-rcv8sh22	9	15	with	with	IN
cord-326257-rcv8sh22	9	16	a	a	DT
cord-326257-rcv8sh22	9	17	mid	mid	JJ
cord-326257-rcv8sh22	9	18	-	-	JJ
cord-326257-rcv8sh22	9	19	range	range	JJ
cord-326257-rcv8sh22	9	20	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	9	21	substitution	substitution	NN
cord-326257-rcv8sh22	9	22	rate	rate	NN
cord-326257-rcv8sh22	9	23	of	of	IN
cord-326257-rcv8sh22	9	24	3×10−4	3×10−4	CD
cord-326257-rcv8sh22	9	25	substitutions	substitution	NNS
cord-326257-rcv8sh22	9	26	/	/	SYM
cord-326257-rcv8sh22	9	27	site	site	NN
cord-326257-rcv8sh22	9	28	/	/	SYM
cord-326257-rcv8sh22	9	29	year	year	NN
cord-326257-rcv8sh22	9	30	.	.	.
cord-326257-rcv8sh22	10	1	Almost	almost	RB
cord-326257-rcv8sh22	10	2	half	half	NN
cord-326257-rcv8sh22	10	3	of	of	IN
cord-326257-rcv8sh22	10	4	sequence	sequence	NN
cord-326257-rcv8sh22	10	5	changes	change	NNS
cord-326257-rcv8sh22	10	6	were	be	VBD
cord-326257-rcv8sh22	10	7	C->U	c->u	NN
cord-326257-rcv8sh22	10	8	transitions	transition	NNS
cord-326257-rcv8sh22	10	9	with	with	IN
cord-326257-rcv8sh22	10	10	an	an	DT
cord-326257-rcv8sh22	10	11	8-fold	8-fold	CD
cord-326257-rcv8sh22	10	12	base	base	NN
cord-326257-rcv8sh22	10	13	frequency	frequency	NN
cord-326257-rcv8sh22	10	14	normalised	normalise	VBD
cord-326257-rcv8sh22	10	15	directional	directional	JJ
cord-326257-rcv8sh22	10	16	asymmetry	asymmetry	NN
cord-326257-rcv8sh22	10	17	between	between	IN
cord-326257-rcv8sh22	10	18	C->U	c->u	NN
cord-326257-rcv8sh22	10	19	and	and	CC
cord-326257-rcv8sh22	10	20	U->C	U->C	NNP
cord-326257-rcv8sh22	10	21	substitutions	substitution	NNS
cord-326257-rcv8sh22	10	22	.	.	.
cord-326257-rcv8sh22	11	1	Elevated	elevated	JJ
cord-326257-rcv8sh22	11	2	ratios	ratio	NNS
cord-326257-rcv8sh22	11	3	were	be	VBD
cord-326257-rcv8sh22	11	4	observed	observe	VBN
cord-326257-rcv8sh22	11	5	in	in	IN
cord-326257-rcv8sh22	11	6	other	other	JJ
cord-326257-rcv8sh22	11	7	recently	recently	RB
cord-326257-rcv8sh22	11	8	emerged	emerge	VBD
cord-326257-rcv8sh22	11	9	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	11	10	(	(	-LRB-
cord-326257-rcv8sh22	11	11	SARS	SARS	NNP
cord-326257-rcv8sh22	11	12	-	-	HYPH
cord-326257-rcv8sh22	11	13	CoV	CoV	NNP
cord-326257-rcv8sh22	11	14	and	and	CC
cord-326257-rcv8sh22	11	15	MERS	MERS	NNP
cord-326257-rcv8sh22	11	16	-	-	HYPH
cord-326257-rcv8sh22	11	17	CoV	CoV	NNP
cord-326257-rcv8sh22	11	18	)	)	-RRB-
cord-326257-rcv8sh22	11	19	and	and	CC
cord-326257-rcv8sh22	11	20	to	to	IN
cord-326257-rcv8sh22	11	21	a	a	DT
cord-326257-rcv8sh22	11	22	decreasing	decrease	VBG
cord-326257-rcv8sh22	11	23	degree	degree	NN
cord-326257-rcv8sh22	11	24	in	in	IN
cord-326257-rcv8sh22	11	25	other	other	JJ
cord-326257-rcv8sh22	11	26	human	human	JJ
cord-326257-rcv8sh22	11	27	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	11	28	(	(	-LRB-
cord-326257-rcv8sh22	11	29	HCoV	HCoV	NNP
cord-326257-rcv8sh22	11	30	-	-	HYPH
cord-326257-rcv8sh22	11	31	NL63	NL63	NNP
cord-326257-rcv8sh22	11	32	,	,	,
cord-326257-rcv8sh22	11	33	-OC43	-oc43	NN
cord-326257-rcv8sh22	11	34	,	,	,
cord-326257-rcv8sh22	11	35	-229E	-229E	,
cord-326257-rcv8sh22	11	36	and	and	CC
cord-326257-rcv8sh22	11	37	-HKU1	-HKU1	NNP
cord-326257-rcv8sh22	11	38	)	)	-RRB-
cord-326257-rcv8sh22	11	39	proportionate	proportionate	JJ
cord-326257-rcv8sh22	11	40	to	to	IN
cord-326257-rcv8sh22	11	41	their	-PRON-	PRP$
cord-326257-rcv8sh22	11	42	increasing	increase	VBG
cord-326257-rcv8sh22	11	43	divergence	divergence	NN
cord-326257-rcv8sh22	11	44	.	.	.
cord-326257-rcv8sh22	12	1	C->U	c->u	NN
cord-326257-rcv8sh22	12	2	transitions	transition	NNS
cord-326257-rcv8sh22	12	3	underpinned	underpin	VBN
cord-326257-rcv8sh22	12	4	almost	almost	RB
cord-326257-rcv8sh22	12	5	half	half	NN
cord-326257-rcv8sh22	12	6	of	of	IN
cord-326257-rcv8sh22	12	7	the	the	DT
cord-326257-rcv8sh22	12	8	amino	amino	NN
cord-326257-rcv8sh22	12	9	acid	acid	NN
cord-326257-rcv8sh22	12	10	differences	difference	NNS
cord-326257-rcv8sh22	12	11	between	between	IN
cord-326257-rcv8sh22	12	12	SARS	SARS	NNP
cord-326257-rcv8sh22	12	13	-	-	HYPH
cord-326257-rcv8sh22	12	14	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	12	15	variants	variant	NNS
cord-326257-rcv8sh22	12	16	,	,	,
cord-326257-rcv8sh22	12	17	and	and	CC
cord-326257-rcv8sh22	12	18	occurred	occur	VBD
cord-326257-rcv8sh22	12	19	preferentially	preferentially	RB
cord-326257-rcv8sh22	12	20	in	in	IN
cord-326257-rcv8sh22	12	21	both	both	DT
cord-326257-rcv8sh22	12	22	5’U	5’u	CD
cord-326257-rcv8sh22	12	23	/	/	SYM
cord-326257-rcv8sh22	12	24	A	a	NN
cord-326257-rcv8sh22	12	25	and	and	CC
cord-326257-rcv8sh22	12	26	3’U	3’u	CD
cord-326257-rcv8sh22	12	27	/	/	SYM
cord-326257-rcv8sh22	12	28	A	a	DT
cord-326257-rcv8sh22	12	29	flanking	flanking	JJ
cord-326257-rcv8sh22	12	30	sequence	sequence	NN
cord-326257-rcv8sh22	12	31	contexts	context	NNS
cord-326257-rcv8sh22	12	32	comparable	comparable	JJ
cord-326257-rcv8sh22	12	33	to	to	IN
cord-326257-rcv8sh22	12	34	favoured	favour	VBN
cord-326257-rcv8sh22	12	35	motifs	motif	NNS
cord-326257-rcv8sh22	12	36	of	of	IN
cord-326257-rcv8sh22	12	37	human	human	JJ
cord-326257-rcv8sh22	12	38	APOBEC3	apobec3	NN
cord-326257-rcv8sh22	12	39	proteins	protein	NNS
cord-326257-rcv8sh22	12	40	.	.	.
cord-326257-rcv8sh22	13	1	Marked	mark	VBN
cord-326257-rcv8sh22	13	2	base	base	NN
cord-326257-rcv8sh22	13	3	asymmetries	asymmetry	NNS
cord-326257-rcv8sh22	13	4	observed	observe	VBN
cord-326257-rcv8sh22	13	5	in	in	IN
cord-326257-rcv8sh22	13	6	non	non	JJ
cord-326257-rcv8sh22	13	7	-	-	JJ
cord-326257-rcv8sh22	13	8	pandemic	pandemic	JJ
cord-326257-rcv8sh22	13	9	human	human	JJ
cord-326257-rcv8sh22	13	10	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	13	11	(	(	-LRB-
cord-326257-rcv8sh22	13	12	U>>A	u>>a	NN
cord-326257-rcv8sh22	13	13	>	>	XX
cord-326257-rcv8sh22	13	14	G>>C	G>>C	NNS
cord-326257-rcv8sh22	13	15	)	)	-RRB-
cord-326257-rcv8sh22	13	16	and	and	CC
cord-326257-rcv8sh22	13	17	low	low	JJ
cord-326257-rcv8sh22	13	18	G+C	G+C	NNP
cord-326257-rcv8sh22	13	19	contents	content	NNS
cord-326257-rcv8sh22	13	20	may	may	MD
cord-326257-rcv8sh22	13	21	represent	represent	VB
cord-326257-rcv8sh22	13	22	long	long	JJ
cord-326257-rcv8sh22	13	23	term	term	NN
cord-326257-rcv8sh22	13	24	effects	effect	NNS
cord-326257-rcv8sh22	13	25	of	of	IN
cord-326257-rcv8sh22	13	26	prolonged	prolonged	JJ
cord-326257-rcv8sh22	13	27	C->U	c->u	NN
cord-326257-rcv8sh22	13	28	hypermutation	hypermutation	NN
cord-326257-rcv8sh22	13	29	in	in	IN
cord-326257-rcv8sh22	13	30	their	-PRON-	PRP$
cord-326257-rcv8sh22	13	31	hosts	host	NNS
cord-326257-rcv8sh22	13	32	.	.	.
cord-326257-rcv8sh22	14	1	Importance	importance	NN
cord-326257-rcv8sh22	15	1	The	the	DT
cord-326257-rcv8sh22	15	2	evidence	evidence	NN
cord-326257-rcv8sh22	15	3	that	that	IN
cord-326257-rcv8sh22	15	4	much	much	JJ
cord-326257-rcv8sh22	15	5	of	of	IN
cord-326257-rcv8sh22	15	6	sequence	sequence	NN
cord-326257-rcv8sh22	15	7	change	change	NN
cord-326257-rcv8sh22	15	8	in	in	IN
cord-326257-rcv8sh22	15	9	SARS	SARS	NNP
cord-326257-rcv8sh22	15	10	-	-	HYPH
cord-326257-rcv8sh22	15	11	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	15	12	and	and	CC
cord-326257-rcv8sh22	15	13	other	other	JJ
cord-326257-rcv8sh22	15	14	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	15	15	may	may	MD
cord-326257-rcv8sh22	15	16	be	be	VB
cord-326257-rcv8sh22	15	17	driven	drive	VBN
cord-326257-rcv8sh22	15	18	by	by	IN
cord-326257-rcv8sh22	15	19	a	a	DT
cord-326257-rcv8sh22	15	20	host	host	NN
cord-326257-rcv8sh22	15	21	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	15	22	-	-	HYPH
cord-326257-rcv8sh22	15	23	like	like	JJ
cord-326257-rcv8sh22	15	24	editing	editing	NN
cord-326257-rcv8sh22	15	25	process	process	NN
cord-326257-rcv8sh22	15	26	has	have	VBZ
cord-326257-rcv8sh22	15	27	profound	profound	JJ
cord-326257-rcv8sh22	15	28	implications	implication	NNS
cord-326257-rcv8sh22	15	29	for	for	IN
cord-326257-rcv8sh22	15	30	understanding	understand	VBG
cord-326257-rcv8sh22	15	31	their	-PRON-	PRP$
cord-326257-rcv8sh22	15	32	short	short	JJ
cord-326257-rcv8sh22	15	33	and	and	CC
cord-326257-rcv8sh22	15	34	long	long	JJ
cord-326257-rcv8sh22	15	35	term	term	NN
cord-326257-rcv8sh22	15	36	evolution	evolution	NN
cord-326257-rcv8sh22	15	37	.	.	.
cord-326257-rcv8sh22	16	1	Repeated	repeat	VBN
cord-326257-rcv8sh22	16	2	cycles	cycle	NNS
cord-326257-rcv8sh22	16	3	of	of	IN
cord-326257-rcv8sh22	16	4	mutation	mutation	NN
cord-326257-rcv8sh22	16	5	and	and	CC
cord-326257-rcv8sh22	16	6	reversion	reversion	NN
cord-326257-rcv8sh22	16	7	in	in	IN
cord-326257-rcv8sh22	16	8	favoured	favour	VBN
cord-326257-rcv8sh22	16	9	mutational	mutational	JJ
cord-326257-rcv8sh22	16	10	hotspots	hotspot	NNS
cord-326257-rcv8sh22	16	11	and	and	CC
cord-326257-rcv8sh22	16	12	the	the	DT
cord-326257-rcv8sh22	16	13	widespread	widespread	JJ
cord-326257-rcv8sh22	16	14	occurrence	occurrence	NN
cord-326257-rcv8sh22	16	15	of	of	IN
cord-326257-rcv8sh22	16	16	amino	amino	NN
cord-326257-rcv8sh22	16	17	acid	acid	NN
cord-326257-rcv8sh22	16	18	changes	change	NNS
cord-326257-rcv8sh22	16	19	with	with	IN
cord-326257-rcv8sh22	16	20	no	no	DT
cord-326257-rcv8sh22	16	21	adaptive	adaptive	JJ
cord-326257-rcv8sh22	16	22	value	value	NN
cord-326257-rcv8sh22	16	23	for	for	IN
cord-326257-rcv8sh22	16	24	the	the	DT
cord-326257-rcv8sh22	16	25	virus	virus	NN
cord-326257-rcv8sh22	16	26	represents	represent	VBZ
cord-326257-rcv8sh22	16	27	a	a	DT
cord-326257-rcv8sh22	16	28	quite	quite	RB
cord-326257-rcv8sh22	16	29	different	different	JJ
cord-326257-rcv8sh22	16	30	paradigm	paradigm	NN
cord-326257-rcv8sh22	16	31	of	of	IN
cord-326257-rcv8sh22	16	32	virus	virus	NN
cord-326257-rcv8sh22	16	33	sequence	sequence	NN
cord-326257-rcv8sh22	16	34	change	change	NN
cord-326257-rcv8sh22	16	35	from	from	IN
cord-326257-rcv8sh22	16	36	neutral	neutral	JJ
cord-326257-rcv8sh22	16	37	and	and	CC
cord-326257-rcv8sh22	16	38	Darwinian	darwinian	JJ
cord-326257-rcv8sh22	16	39	evolutionary	evolutionary	JJ
cord-326257-rcv8sh22	16	40	frameworks	framework	NNS
cord-326257-rcv8sh22	16	41	that	that	WDT
cord-326257-rcv8sh22	16	42	are	be	VBP
cord-326257-rcv8sh22	16	43	typically	typically	RB
cord-326257-rcv8sh22	16	44	used	use	VBN
cord-326257-rcv8sh22	16	45	in	in	IN
cord-326257-rcv8sh22	16	46	molecular	molecular	JJ
cord-326257-rcv8sh22	16	47	epidemiology	epidemiology	NN
cord-326257-rcv8sh22	16	48	investigations	investigation	NNS
cord-326257-rcv8sh22	16	49	.	.	.
cord-326257-rcv8sh22	17	1	SARS	SARS	NNP
cord-326257-rcv8sh22	17	2	-	-	HYPH
cord-326257-rcv8sh22	17	3	coronavirus-2	coronavirus-2	NNP
cord-326257-rcv8sh22	18	1	(	(	-LRB-
cord-326257-rcv8sh22	18	2	SARS	SARS	NNP
cord-326257-rcv8sh22	18	3	-	-	HYPH
cord-326257-rcv8sh22	18	4	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	18	5	)	)	-RRB-
cord-326257-rcv8sh22	18	6	emerged	emerge	VBD
cord-326257-rcv8sh22	18	7	late	late	JJ
cord-326257-rcv8sh22	18	8	2019	2019	CD
cord-326257-rcv8sh22	18	9	in	in	IN
cord-326257-rcv8sh22	18	10	the	the	DT
cord-326257-rcv8sh22	18	11	Hubei	Hubei	NNP
cord-326257-rcv8sh22	18	12	province	province	NN
cord-326257-rcv8sh22	18	13	,	,	,
cord-326257-rcv8sh22	18	14	China	China	NNP
cord-326257-rcv8sh22	18	15	as	as	IN
cord-326257-rcv8sh22	18	16	a	a	DT
cord-326257-rcv8sh22	18	17	cause	cause	NN
cord-326257-rcv8sh22	18	18	of	of	IN
cord-326257-rcv8sh22	18	19	respiratory	respiratory	JJ
cord-326257-rcv8sh22	18	20	disease	disease	NN
cord-326257-rcv8sh22	18	21	occasionally	occasionally	RB
cord-326257-rcv8sh22	18	22	leading	lead	VBG
cord-326257-rcv8sh22	18	23	to	to	IN
cord-326257-rcv8sh22	18	24	acute	acute	JJ
cord-326257-rcv8sh22	18	25	respiratory	respiratory	JJ
cord-326257-rcv8sh22	18	26	distress	distress	NN
cord-326257-rcv8sh22	18	27	syndrome	syndrome	NN
cord-326257-rcv8sh22	18	28	and	and	CC
cord-326257-rcv8sh22	18	29	death	death	NN
cord-326257-rcv8sh22	18	30	(	(	-LRB-
cord-326257-rcv8sh22	18	31	COVID-	covid-	NN
cord-326257-rcv8sh22	18	32	19	19	CD
cord-326257-rcv8sh22	18	33	)	)	-RRB-
cord-326257-rcv8sh22	18	34	(	(	-LRB-
cord-326257-rcv8sh22	18	35	1	1	CD
cord-326257-rcv8sh22	18	36	-	-	SYM
cord-326257-rcv8sh22	18	37	4	4	CD
cord-326257-rcv8sh22	18	38	)	)	-RRB-
cord-326257-rcv8sh22	18	39	.	.	.
cord-326257-rcv8sh22	19	1	Since	since	IN
cord-326257-rcv8sh22	19	2	the	the	DT
cord-326257-rcv8sh22	19	3	first	first	JJ
cord-326257-rcv8sh22	19	4	reports	report	NNS
cord-326257-rcv8sh22	19	5	in	in	IN
cord-326257-rcv8sh22	19	6	December	December	NNP
cord-326257-rcv8sh22	19	7	,	,	,
cord-326257-rcv8sh22	19	8	2019	2019	CD
cord-326257-rcv8sh22	19	9	,	,	,
cord-326257-rcv8sh22	19	10	infections	infection	NNS
cord-326257-rcv8sh22	19	11	with	with	IN
cord-326257-rcv8sh22	19	12	SARS	SARS	NNP
cord-326257-rcv8sh22	19	13	-	-	HYPH
cord-326257-rcv8sh22	19	14	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	19	15	have	have	VBP
cord-326257-rcv8sh22	19	16	been	be	VBN
cord-326257-rcv8sh22	19	17	reported	report	VBN
cord-326257-rcv8sh22	19	18	45	45	CD
cord-326257-rcv8sh22	19	19	from	from	IN
cord-326257-rcv8sh22	19	20	a	a	DT
cord-326257-rcv8sh22	19	21	rapidly	rapidly	RB
cord-326257-rcv8sh22	19	22	increasing	increase	VBG
cord-326257-rcv8sh22	19	23	number	number	NN
cord-326257-rcv8sh22	19	24	of	of	IN
cord-326257-rcv8sh22	19	25	countries	country	NNS
cord-326257-rcv8sh22	19	26	worldwide	worldwide	RB
cord-326257-rcv8sh22	19	27	,	,	,
cord-326257-rcv8sh22	19	28	and	and	CC
cord-326257-rcv8sh22	19	29	led	lead	VBD
cord-326257-rcv8sh22	19	30	to	to	IN
cord-326257-rcv8sh22	19	31	its	-PRON-	PRP$
cord-326257-rcv8sh22	19	32	declaration	declaration	NN
cord-326257-rcv8sh22	19	33	as	as	IN
cord-326257-rcv8sh22	19	34	a	a	DT
cord-326257-rcv8sh22	19	35	pandemic	pandemic	NN
cord-326257-rcv8sh22	19	36	by	by	IN
cord-326257-rcv8sh22	19	37	the	the	DT
cord-326257-rcv8sh22	19	38	World	World	NNP
cord-326257-rcv8sh22	19	39	Health	Health	NNP
cord-326257-rcv8sh22	19	40	Organisation	Organisation	NNP
cord-326257-rcv8sh22	19	41	in	in	IN
cord-326257-rcv8sh22	19	42	March	March	NNP
cord-326257-rcv8sh22	19	43	,	,	,
cord-326257-rcv8sh22	19	44	2020	2020	CD
cord-326257-rcv8sh22	19	45	.	.	.
cord-326257-rcv8sh22	20	1	In	in	IN
cord-326257-rcv8sh22	20	2	order	order	NN
cord-326257-rcv8sh22	20	3	to	to	TO
cord-326257-rcv8sh22	20	4	understand	understand	VB
cord-326257-rcv8sh22	20	5	the	the	DT
cord-326257-rcv8sh22	20	6	origins	origin	NNS
cord-326257-rcv8sh22	20	7	and	and	CC
cord-326257-rcv8sh22	20	8	transmission	transmission	NN
cord-326257-rcv8sh22	20	9	dynamics	dynamic	NNS
cord-326257-rcv8sh22	20	10	of	of	IN
cord-326257-rcv8sh22	20	11	SARS	SARS	NNP
cord-326257-rcv8sh22	20	12	-	-	HYPH
cord-326257-rcv8sh22	20	13	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	20	14	,	,	,
cord-326257-rcv8sh22	20	15	sequencing	sequencing	NN
cord-326257-rcv8sh22	20	16	of	of	IN
cord-326257-rcv8sh22	20	17	SARS	SARS	NNP
cord-326257-rcv8sh22	20	18	-	-	:
cord-326257-rcv8sh22	20	19	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	20	20	directly	directly	RB
cord-326257-rcv8sh22	20	21	from	from	IN
cord-326257-rcv8sh22	20	22	samples	sample	NNS
cord-326257-rcv8sh22	20	23	of	of	IN
cord-326257-rcv8sh22	20	24	infected	infected	JJ
cord-326257-rcv8sh22	20	25	individuals	individual	NNS
cord-326257-rcv8sh22	20	26	worldwide	worldwide	RB
cord-326257-rcv8sh22	20	27	has	have	VBZ
cord-326257-rcv8sh22	20	28	been	be	VBN
cord-326257-rcv8sh22	20	29	performed	perform	VBN
cord-326257-rcv8sh22	20	30	on	on	IN
cord-326257-rcv8sh22	20	31	an	an	DT
cord-326257-rcv8sh22	20	32	unprecedented	unprecedented	JJ
cord-326257-rcv8sh22	20	33	scale	scale	NN
cord-326257-rcv8sh22	20	34	.	.	.
cord-326257-rcv8sh22	21	1	These	these	DT
cord-326257-rcv8sh22	21	2	efforts	effort	NNS
cord-326257-rcv8sh22	21	3	have	have	VBP
cord-326257-rcv8sh22	21	4	generated	generate	VBN
cord-326257-rcv8sh22	21	5	many	many	JJ
cord-326257-rcv8sh22	21	6	thousands	thousand	NNS
cord-326257-rcv8sh22	21	7	of	of	IN
cord-326257-rcv8sh22	21	8	high	high	JJ
cord-326257-rcv8sh22	21	9	quality	quality	NN
cord-326257-rcv8sh22	21	10	consensus	consensus	NN
cord-326257-rcv8sh22	21	11	sequences	sequence	NNS
cord-326257-rcv8sh22	21	12	spanning	span	VBG
cord-326257-rcv8sh22	21	13	the	the	DT
cord-326257-rcv8sh22	21	14	length	length	NN
cord-326257-rcv8sh22	21	15	of	of	IN
cord-326257-rcv8sh22	21	16	the	the	DT
cord-326257-rcv8sh22	21	17	genome	genome	NN
cord-326257-rcv8sh22	21	18	and	and	CC
cord-326257-rcv8sh22	21	19	have	have	VBP
cord-326257-rcv8sh22	21	20	defined	define	VBN
cord-326257-rcv8sh22	21	21	50	50	CD
cord-326257-rcv8sh22	21	22	a	a	DT
cord-326257-rcv8sh22	21	23	series	series	NN
cord-326257-rcv8sh22	21	24	of	of	IN
cord-326257-rcv8sh22	21	25	geographically	geographically	RB
cord-326257-rcv8sh22	21	26	defined	define	VBN
cord-326257-rcv8sh22	21	27	clusters	cluster	NNS
cord-326257-rcv8sh22	21	28	that	that	WDT
cord-326257-rcv8sh22	21	29	recapitulate	recapitulate	VBP
cord-326257-rcv8sh22	21	30	the	the	DT
cord-326257-rcv8sh22	21	31	early	early	JJ
cord-326257-rcv8sh22	21	32	routes	route	NNS
cord-326257-rcv8sh22	21	33	of	of	IN
cord-326257-rcv8sh22	21	34	international	international	JJ
cord-326257-rcv8sh22	21	35	spread	spread	NN
cord-326257-rcv8sh22	21	36	.	.	.
cord-326257-rcv8sh22	22	1	However	however	RB
cord-326257-rcv8sh22	22	2	,	,	,
cord-326257-rcv8sh22	22	3	as	as	IN
cord-326257-rcv8sh22	22	4	commented	comment	VBN
cord-326257-rcv8sh22	22	5	elsewhere	elsewhere	RB
cord-326257-rcv8sh22	22	6	(	(	-LRB-
cord-326257-rcv8sh22	22	7	https://doi.org/10.1101/2020.03	https://doi.org/10.1101/2020.03	ADD
cord-326257-rcv8sh22	22	8	.	.	.
cord-326257-rcv8sh22	23	1	16.20034470	16.20034470	CD
cord-326257-rcv8sh22	23	2	)	)	-RRB-
cord-326257-rcv8sh22	23	3	,	,	,
cord-326257-rcv8sh22	23	4	there	there	EX
cord-326257-rcv8sh22	23	5	is	be	VBZ
cord-326257-rcv8sh22	23	6	remarkable	remarkable	JJ
cord-326257-rcv8sh22	23	7	little	little	JJ
cord-326257-rcv8sh22	23	8	virus	virus	NN
cord-326257-rcv8sh22	23	9	diversity	diversity	NN
cord-326257-rcv8sh22	23	10	at	at	IN
cord-326257-rcv8sh22	23	11	this	this	DT
cord-326257-rcv8sh22	23	12	early	early	JJ
cord-326257-rcv8sh22	23	13	stage	stage	NN
cord-326257-rcv8sh22	23	14	of	of	IN
cord-326257-rcv8sh22	23	15	the	the	DT
cord-326257-rcv8sh22	23	16	pandemic	pandemic	NN
cord-326257-rcv8sh22	23	17	and	and	CC
cord-326257-rcv8sh22	23	18	analyses	analysis	NNS
cord-326257-rcv8sh22	23	19	of	of	IN
cord-326257-rcv8sh22	23	20	its	-PRON-	PRP$
cord-326257-rcv8sh22	23	21	evolutionary	evolutionary	JJ
cord-326257-rcv8sh22	23	22	dynamics	dynamic	NNS
cord-326257-rcv8sh22	23	23	remain	remain	VBP
cord-326257-rcv8sh22	23	24	at	at	IN
cord-326257-rcv8sh22	23	25	an	an	DT
cord-326257-rcv8sh22	23	26	early	early	JJ
cord-326257-rcv8sh22	23	27	stage	stage	NN
cord-326257-rcv8sh22	23	28	.	.	.
cord-326257-rcv8sh22	24	1	The	the	DT
cord-326257-rcv8sh22	24	2	relative	relative	JJ
cord-326257-rcv8sh22	24	3	infrequency	infrequency	NN
cord-326257-rcv8sh22	24	4	of	of	IN
cord-326257-rcv8sh22	24	5	substitutions	substitution	NNS
cord-326257-rcv8sh22	24	6	is	be	VBZ
cord-326257-rcv8sh22	24	7	the	the	DT
cord-326257-rcv8sh22	24	8	consequence	consequence	NN
cord-326257-rcv8sh22	24	9	of	of	IN
cord-326257-rcv8sh22	24	10	a	a	DT
cord-326257-rcv8sh22	24	11	much	much	RB
cord-326257-rcv8sh22	24	12	lower	low	JJR
cord-326257-rcv8sh22	24	13	error	error	NN
cord-326257-rcv8sh22	24	14	rate	rate	NN
cord-326257-rcv8sh22	24	15	on	on	IN
cord-326257-rcv8sh22	24	16	genome	genome	NN
cord-326257-rcv8sh22	24	17	copying	copying	NN
cord-326257-rcv8sh22	24	18	by	by	IN
cord-326257-rcv8sh22	24	19	the	the	DT
cord-326257-rcv8sh22	24	20	viral	viral	JJ
cord-326257-rcv8sh22	24	21	RNA	RNA	NNP
cord-326257-rcv8sh22	24	22	polymerase	polymerase	NN
cord-326257-rcv8sh22	24	23	of	of	IN
cord-326257-rcv8sh22	24	24	the	the	DT
cord-326257-rcv8sh22	24	25	larger	large	JJR
cord-326257-rcv8sh22	24	26	nidovirales	nidovirale	NNS
cord-326257-rcv8sh22	24	27	,	,	,
cord-326257-rcv8sh22	24	28	including	include	VBG
cord-326257-rcv8sh22	24	29	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	24	30	.	.	.
cord-326257-rcv8sh22	25	1	This	this	DT
cord-326257-rcv8sh22	25	2	is	be	VBZ
cord-326257-rcv8sh22	25	3	achieved	achieve	VBN
cord-326257-rcv8sh22	25	4	through	through	IN
cord-326257-rcv8sh22	25	5	the	the	DT
cord-326257-rcv8sh22	25	6	development	development	NN
cord-326257-rcv8sh22	25	7	of	of	IN
cord-326257-rcv8sh22	25	8	a	a	DT
cord-326257-rcv8sh22	25	9	proofreading	proofreading	NN
cord-326257-rcv8sh22	25	10	capability	capability	NN
cord-326257-rcv8sh22	25	11	through	through	IN
cord-326257-rcv8sh22	25	12	mismatch	mismatch	NN
cord-326257-rcv8sh22	25	13	detection	detection	NN
cord-326257-rcv8sh22	25	14	and	and	CC
cord-326257-rcv8sh22	25	15	excision	excision	NN
cord-326257-rcv8sh22	25	16	by	by	IN
cord-326257-rcv8sh22	25	17	a	a	DT
cord-326257-rcv8sh22	25	18	viral	viral	JJ
cord-326257-rcv8sh22	25	19	encoded	encode	VBN
cord-326257-rcv8sh22	25	20	exonuclease	exonuclease	NN
cord-326257-rcv8sh22	25	21	,	,	,
cord-326257-rcv8sh22	25	22	Nsp14-ExoN	Nsp14-ExoN	NNP
cord-326257-rcv8sh22	25	23	(	(	-LRB-
cord-326257-rcv8sh22	25	24	5	5	CD
cord-326257-rcv8sh22	25	25	-	-	SYM
cord-326257-rcv8sh22	25	26	7	7	CD
cord-326257-rcv8sh22	25	27	)	)	-RRB-
cord-326257-rcv8sh22	25	28	.	.	.
cord-326257-rcv8sh22	26	1	Consequently	consequently	RB
cord-326257-rcv8sh22	26	2	,	,	,
cord-326257-rcv8sh22	26	3	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	26	4	show	show	VBP
cord-326257-rcv8sh22	26	5	a	a	DT
cord-326257-rcv8sh22	26	6	low	low	JJ
cord-326257-rcv8sh22	26	7	substitution	substitution	NN
cord-326257-rcv8sh22	26	8	rate	rate	NN
cord-326257-rcv8sh22	26	9	over	over	IN
cord-326257-rcv8sh22	26	10	time	time	NN
cord-326257-rcv8sh22	26	11	,	,	,
cord-326257-rcv8sh22	26	12	typically	typically	RB
cord-326257-rcv8sh22	26	13	in	in	IN
cord-326257-rcv8sh22	26	14	the	the	DT
cord-326257-rcv8sh22	26	15	range	range	NN
cord-326257-rcv8sh22	26	16	of	of	IN
cord-326257-rcv8sh22	26	17	1.5	1.5	CD
cord-326257-rcv8sh22	26	18	-10	-10	NNS
cord-326257-rcv8sh22	26	19	x	x	SYM
cord-326257-rcv8sh22	26	20	10	10	CD
cord-326257-rcv8sh22	26	21	-4	-4	NN
cord-326257-rcv8sh22	26	22	substitutions	substitution	NNS
cord-326257-rcv8sh22	26	23	per	per	IN
cord-326257-rcv8sh22	26	24	site	site	NN
cord-326257-rcv8sh22	26	25	per	per	IN
cord-326257-rcv8sh22	26	26	year	year	NN
cord-326257-rcv8sh22	26	27	(	(	-LRB-
cord-326257-rcv8sh22	26	28	SSY	SSY	NNP
cord-326257-rcv8sh22	26	29	)	)	-RRB-
cord-326257-rcv8sh22	27	1	(	(	-LRB-
cord-326257-rcv8sh22	27	2	8-	8-	NNP
cord-326257-rcv8sh22	27	3	13	13	CD
cord-326257-rcv8sh22	27	4	)	)	-RRB-
cord-326257-rcv8sh22	27	5	.	.	.
cord-326257-rcv8sh22	28	1	60	60	CD
cord-326257-rcv8sh22	29	1	Applying	apply	VBG
cord-326257-rcv8sh22	29	2	a	a	DT
cord-326257-rcv8sh22	29	3	mid	mid	JJ
cord-326257-rcv8sh22	29	4	-	-	JJ
cord-326257-rcv8sh22	29	5	range	range	JJ
cord-326257-rcv8sh22	29	6	estimate	estimate	NN
cord-326257-rcv8sh22	29	7	to	to	IN
cord-326257-rcv8sh22	29	8	the	the	DT
cord-326257-rcv8sh22	29	9	3	3	CD
cord-326257-rcv8sh22	29	10	-	-	SYM
cord-326257-rcv8sh22	29	11	5	5	CD
cord-326257-rcv8sh22	29	12	month	month	NN
cord-326257-rcv8sh22	29	13	timescale	timescale	NN
cord-326257-rcv8sh22	29	14	of	of	IN
cord-326257-rcv8sh22	29	15	the	the	DT
cord-326257-rcv8sh22	29	16	SARS	SARS	NNP
cord-326257-rcv8sh22	29	17	-	-	HYPH
cord-326257-rcv8sh22	29	18	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	29	19	pandemic	pandemic	NN
cord-326257-rcv8sh22	29	20	indicates	indicate	VBZ
cord-326257-rcv8sh22	29	21	that	that	IN
cord-326257-rcv8sh22	29	22	epidemiologically	epidemiologically	RB
cord-326257-rcv8sh22	29	23	unrelated	unrelated	JJ
cord-326257-rcv8sh22	29	24	strains	strain	NNS
cord-326257-rcv8sh22	29	25	might	may	MD
cord-326257-rcv8sh22	29	26	show	show	VB
cord-326257-rcv8sh22	29	27	around	around	RB
cord-326257-rcv8sh22	29	28	6	6	CD
cord-326257-rcv8sh22	29	29	-	-	SYM
cord-326257-rcv8sh22	29	30	10	10	CD
cord-326257-rcv8sh22	29	31	nucleotides	nucleotide	NNS
cord-326257-rcv8sh22	29	32	differences	difference	NNS
cord-326257-rcv8sh22	29	33	from	from	IN
cord-326257-rcv8sh22	29	34	each	each	DT
cord-326257-rcv8sh22	29	35	other	other	JJ
cord-326257-rcv8sh22	29	36	over	over	IN
cord-326257-rcv8sh22	29	37	the	the	DT
cord-326257-rcv8sh22	29	38	30,000	30,000	CD
cord-326257-rcv8sh22	29	39	base	base	NN
cord-326257-rcv8sh22	29	40	length	length	NN
cord-326257-rcv8sh22	29	41	of	of	IN
cord-326257-rcv8sh22	29	42	their	-PRON-	PRP$
cord-326257-rcv8sh22	29	43	genomes	genome	NNS
cord-326257-rcv8sh22	29	44	.	.	.
cord-326257-rcv8sh22	30	1	In	in	IN
cord-326257-rcv8sh22	30	2	the	the	DT
cord-326257-rcv8sh22	30	3	current	current	JJ
cord-326257-rcv8sh22	30	4	study	study	NN
cord-326257-rcv8sh22	30	5	,	,	,
cord-326257-rcv8sh22	30	6	we	-PRON-	PRP
cord-326257-rcv8sh22	30	7	have	have	VBP
cord-326257-rcv8sh22	30	8	analysed	analyse	VBN
cord-326257-rcv8sh22	30	9	the	the	DT
cord-326257-rcv8sh22	30	10	nature	nature	NN
cord-326257-rcv8sh22	30	11	of	of	IN
cord-326257-rcv8sh22	30	12	the	the	DT
cord-326257-rcv8sh22	30	13	sequence	sequence	NN
cord-326257-rcv8sh22	30	14	diversity	diversity	NN
cord-326257-rcv8sh22	30	15	generated	generate	VBN
cord-326257-rcv8sh22	30	16	within	within	IN
cord-326257-rcv8sh22	30	17	the	the	DT
cord-326257-rcv8sh22	30	18	65	65	CD
cord-326257-rcv8sh22	30	19	SARS	SARS	NNP
cord-326257-rcv8sh22	30	20	-	-	HYPH
cord-326257-rcv8sh22	30	21	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	30	22	virus	virus	NN
cord-326257-rcv8sh22	30	23	populations	population	NNS
cord-326257-rcv8sh22	30	24	revealed	reveal	VBN
cord-326257-rcv8sh22	30	25	by	by	IN
cord-326257-rcv8sh22	30	26	current	current	JJ
cord-326257-rcv8sh22	30	27	and	and	CC
cord-326257-rcv8sh22	30	28	ongoing	ongoing	JJ
cord-326257-rcv8sh22	30	29	virus	virus	NN
cord-326257-rcv8sh22	30	30	sequencing	sequencing	NN
cord-326257-rcv8sh22	30	31	studies	study	NNS
cord-326257-rcv8sh22	30	32	.	.	.
cord-326257-rcv8sh22	31	1	We	-PRON-	PRP
cord-326257-rcv8sh22	31	2	obtained	obtain	VBD
cord-326257-rcv8sh22	31	3	evidence	evidence	NN
cord-326257-rcv8sh22	31	4	for	for	IN
cord-326257-rcv8sh22	31	5	a	a	DT
cord-326257-rcv8sh22	31	6	preponderance	preponderance	NN
cord-326257-rcv8sh22	31	7	of	of	IN
cord-326257-rcv8sh22	31	8	driven	drive	VBN
cord-326257-rcv8sh22	31	9	mutational	mutational	JJ
cord-326257-rcv8sh22	31	10	events	event	NNS
cord-326257-rcv8sh22	31	11	within	within	IN
cord-326257-rcv8sh22	31	12	the	the	DT
cord-326257-rcv8sh22	31	13	short	short	JJ
cord-326257-rcv8sh22	31	14	evolutionary	evolutionary	JJ
cord-326257-rcv8sh22	31	15	period	period	NN
cord-326257-rcv8sh22	31	16	following	follow	VBG
cord-326257-rcv8sh22	31	17	the	the	DT
cord-326257-rcv8sh22	31	18	zoonotic	zoonotic	JJ
cord-326257-rcv8sh22	31	19	transmission	transmission	NN
cord-326257-rcv8sh22	31	20	of	of	IN
cord-326257-rcv8sh22	31	21	SARS	SARS	NNP
cord-326257-rcv8sh22	31	22	-	-	HYPH
cord-326257-rcv8sh22	31	23	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	31	24	into	into	IN
cord-326257-rcv8sh22	31	25	humans	human	NNS
cord-326257-rcv8sh22	31	26	.	.	.
cord-326257-rcv8sh22	32	1	Sequence	sequence	NN
cord-326257-rcv8sh22	32	2	substitutions	substitution	NNS
cord-326257-rcv8sh22	32	3	were	be	VBD
cord-326257-rcv8sh22	32	4	characterised	characterise	VBN
cord-326257-rcv8sh22	32	5	by	by	IN
cord-326257-rcv8sh22	32	6	a	a	DT
cord-326257-rcv8sh22	32	7	preponderance	preponderance	NN
cord-326257-rcv8sh22	32	8	of	of	IN
cord-326257-rcv8sh22	32	9	cytidine	cytidine	NNP
cord-326257-rcv8sh22	32	10	to	to	IN
cord-326257-rcv8sh22	32	11	uridine	uridine	NNP
cord-326257-rcv8sh22	32	12	(	(	-LRB-
cord-326257-rcv8sh22	32	13	C->U	c->u	NN
cord-326257-rcv8sh22	32	14	)	)	-RRB-
cord-326257-rcv8sh22	32	15	transitions	transition	NNS
cord-326257-rcv8sh22	32	16	.	.	.
cord-326257-rcv8sh22	33	1	The	the	DT
cord-326257-rcv8sh22	33	2	possibility	possibility	NN
cord-326257-rcv8sh22	33	3	that	that	IN
cord-326257-rcv8sh22	33	4	the	the	DT
cord-326257-rcv8sh22	33	5	initial	initial	JJ
cord-326257-rcv8sh22	33	6	diversity	diversity	NN
cord-326257-rcv8sh22	33	7	within	within	IN
cord-326257-rcv8sh22	33	8	a	a	DT
cord-326257-rcv8sh22	33	9	viral	viral	JJ
cord-326257-rcv8sh22	33	10	population	population	NN
cord-326257-rcv8sh22	33	11	was	be	VBD
cord-326257-rcv8sh22	33	12	largely	largely	RB
cord-326257-rcv8sh22	33	13	host	host	NN
cord-326257-rcv8sh22	33	14	-	-	HYPH
cord-326257-rcv8sh22	33	15	induced	induce	VBN
cord-326257-rcv8sh22	33	16	would	would	MD
cord-326257-rcv8sh22	33	17	have	have	VB
cord-326257-rcv8sh22	33	18	major	major	JJ
cord-326257-rcv8sh22	33	19	implications	implication	NNS
cord-326257-rcv8sh22	33	20	for	for	IN
cord-326257-rcv8sh22	33	21	70	70	CD
cord-326257-rcv8sh22	33	22	evolutionary	evolutionary	JJ
cord-326257-rcv8sh22	33	23	reconstruction	reconstruction	NN
cord-326257-rcv8sh22	33	24	of	of	IN
cord-326257-rcv8sh22	33	25	SARS	SARS	NNP
cord-326257-rcv8sh22	33	26	-	-	HYPH
cord-326257-rcv8sh22	33	27	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	33	28	variants	variant	NNS
cord-326257-rcv8sh22	33	29	in	in	IN
cord-326257-rcv8sh22	33	30	the	the	DT
cord-326257-rcv8sh22	33	31	current	current	JJ
cord-326257-rcv8sh22	33	32	pandemic	pandemic	NN
cord-326257-rcv8sh22	33	33	,	,	,
cord-326257-rcv8sh22	33	34	as	as	RB
cord-326257-rcv8sh22	33	35	well	well	RB
cord-326257-rcv8sh22	33	36	as	as	IN
cord-326257-rcv8sh22	33	37	in	in	IN
cord-326257-rcv8sh22	33	38	our	-PRON-	PRP$
cord-326257-rcv8sh22	33	39	understanding	understanding	NN
cord-326257-rcv8sh22	33	40	both	both	DT
cord-326257-rcv8sh22	33	41	of	of	IN
cord-326257-rcv8sh22	33	42	host	host	NN
cord-326257-rcv8sh22	33	43	antiviral	antiviral	JJ
cord-326257-rcv8sh22	33	44	pathways	pathway	NNS
cord-326257-rcv8sh22	33	45	against	against	IN
cord-326257-rcv8sh22	33	46	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	34	1	and	and	CC
cord-326257-rcv8sh22	34	2	the	the	DT
cord-326257-rcv8sh22	34	3	longer	long	JJR
cord-326257-rcv8sh22	34	4	term	term	NN
cord-326257-rcv8sh22	34	5	shaping	shape	VBG
cord-326257-rcv8sh22	34	6	effects	effect	NNS
cord-326257-rcv8sh22	34	7	on	on	IN
cord-326257-rcv8sh22	34	8	their	-PRON-	PRP$
cord-326257-rcv8sh22	34	9	genome	genome	NN
cord-326257-rcv8sh22	34	10	composition	composition	NN
cord-326257-rcv8sh22	34	11	.	.	.
cord-326257-rcv8sh22	35	1	Sequence	sequence	NN
cord-326257-rcv8sh22	35	2	changes	change	NNS
cord-326257-rcv8sh22	35	3	in	in	IN
cord-326257-rcv8sh22	35	4	SARS	SARS	NNP
cord-326257-rcv8sh22	35	5	-	-	HYPH
cord-326257-rcv8sh22	35	6	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	35	7	.	.	.
cord-326257-rcv8sh22	36	1	Four	four	CD
cord-326257-rcv8sh22	36	2	separate	separate	JJ
cord-326257-rcv8sh22	36	3	datasets	dataset	NNS
cord-326257-rcv8sh22	36	4	of	of	IN
cord-326257-rcv8sh22	36	5	full	full	JJ
cord-326257-rcv8sh22	36	6	length	length	NN
cord-326257-rcv8sh22	36	7	,	,	,
cord-326257-rcv8sh22	36	8	(	(	-LRB-
cord-326257-rcv8sh22	36	9	near-	near-	NN
cord-326257-rcv8sh22	36	10	)	)	-RRB-
cord-326257-rcv8sh22	36	11	complete	complete	JJ
cord-326257-rcv8sh22	36	12	genome	genome	NN
cord-326257-rcv8sh22	36	13	sequences	sequence	NNS
cord-326257-rcv8sh22	36	14	of	of	IN
cord-326257-rcv8sh22	36	15	SARS	SARS	NNP
cord-326257-rcv8sh22	36	16	-	-	HYPH
cord-326257-rcv8sh22	36	17	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	36	18	sequences	sequence	NNS
cord-326257-rcv8sh22	36	19	collected	collect	VBN
cord-326257-rcv8sh22	36	20	from	from	IN
cord-326257-rcv8sh22	36	21	the	the	DT
cord-326257-rcv8sh22	36	22	start	start	NN
cord-326257-rcv8sh22	36	23	of	of	IN
cord-326257-rcv8sh22	36	24	the	the	DT
cord-326257-rcv8sh22	36	25	pandemic	pandemic	NN
cord-326257-rcv8sh22	36	26	to	to	IN
cord-326257-rcv8sh22	36	27	those	those	DT
cord-326257-rcv8sh22	36	28	most	most	RBS
cord-326257-rcv8sh22	36	29	recently	recently	RB
cord-326257-rcv8sh22	36	30	deposited	deposit	VBN
cord-326257-rcv8sh22	36	31	on	on	IN
cord-326257-rcv8sh22	36	32	the	the	DT
cord-326257-rcv8sh22	36	33	24	24	CD
cord-326257-rcv8sh22	36	34	th	th	CD
cord-326257-rcv8sh22	36	35	April	April	NNP
cord-326257-rcv8sh22	36	36	,	,	,
cord-326257-rcv8sh22	36	37	2020	2020	CD
cord-326257-rcv8sh22	36	38	were	be	VBD
cord-326257-rcv8sh22	36	39	aligned	align	VBN
cord-326257-rcv8sh22	36	40	and	and	CC
cord-326257-rcv8sh22	36	41	analysed	analyse	VBN
cord-326257-rcv8sh22	36	42	.	.	.
cord-326257-rcv8sh22	37	1	Each	each	DT
cord-326257-rcv8sh22	37	2	dataset	dataset	NN
cord-326257-rcv8sh22	37	3	showed	show	VBD
cord-326257-rcv8sh22	37	4	minimal	minimal	JJ
cord-326257-rcv8sh22	37	5	levels	level	NNS
cord-326257-rcv8sh22	37	6	of	of	IN
cord-326257-rcv8sh22	37	7	80	80	CD
cord-326257-rcv8sh22	37	8	sequence	sequence	NN
cord-326257-rcv8sh22	37	9	divergence	divergence	NN
cord-326257-rcv8sh22	37	10	,	,	,
cord-326257-rcv8sh22	37	11	with	with	IN
cord-326257-rcv8sh22	37	12	mean	mean	JJ
cord-326257-rcv8sh22	37	13	pairwise	pairwise	JJ
cord-326257-rcv8sh22	37	14	distances	distance	NNS
cord-326257-rcv8sh22	37	15	ranging	range	VBG
cord-326257-rcv8sh22	37	16	from	from	IN
cord-326257-rcv8sh22	37	17	5.5	5.5	CD
cord-326257-rcv8sh22	37	18	-	-	SYM
cord-326257-rcv8sh22	37	19	9.5	9.5	CD
cord-326257-rcv8sh22	37	20	nucleotide	nucleotide	JJ
cord-326257-rcv8sh22	37	21	differences	difference	NNS
cord-326257-rcv8sh22	37	22	between	between	IN
cord-326257-rcv8sh22	37	23	each	each	DT
cord-326257-rcv8sh22	37	24	sequence	sequence	NN
cord-326257-rcv8sh22	37	25	.	.	.
cord-326257-rcv8sh22	38	1	However	however	RB
cord-326257-rcv8sh22	38	2	,	,	,
cord-326257-rcv8sh22	38	3	several	several	JJ
cord-326257-rcv8sh22	38	4	aspects	aspect	NNS
cord-326257-rcv8sh22	38	5	of	of	IN
cord-326257-rcv8sh22	38	6	the	the	DT
cord-326257-rcv8sh22	38	7	frequencies	frequency	NNS
cord-326257-rcv8sh22	38	8	and	and	CC
cord-326257-rcv8sh22	38	9	sequence	sequence	NN
cord-326257-rcv8sh22	38	10	contexts	contexts	NN
cord-326257-rcv8sh22	38	11	of	of	IN
cord-326257-rcv8sh22	38	12	the	the	DT
cord-326257-rcv8sh22	38	13	observed	observed	JJ
cord-326257-rcv8sh22	38	14	changes	change	NNS
cord-326257-rcv8sh22	38	15	were	be	VBD
cord-326257-rcv8sh22	38	16	unexpected	unexpected	JJ
cord-326257-rcv8sh22	38	17	.	.	.
cord-326257-rcv8sh22	39	1	Firstly	firstly	RB
cord-326257-rcv8sh22	39	2	,	,	,
cord-326257-rcv8sh22	39	3	the	the	DT
cord-326257-rcv8sh22	39	4	ratio	ratio	NN
cord-326257-rcv8sh22	39	5	of	of	IN
cord-326257-rcv8sh22	39	6	non	non	JJ
cord-326257-rcv8sh22	39	7	-	-	JJ
cord-326257-rcv8sh22	39	8	synonymous	synonymous	JJ
cord-326257-rcv8sh22	39	9	(	(	-LRB-
cord-326257-rcv8sh22	39	10	amino	amino	NN
cord-326257-rcv8sh22	39	11	acid	acid	NN
cord-326257-rcv8sh22	39	12	changing	change	VBG
cord-326257-rcv8sh22	39	13	)	)	-RRB-
cord-326257-rcv8sh22	39	14	to	to	IN
cord-326257-rcv8sh22	39	15	synonymous	synonymous	JJ
cord-326257-rcv8sh22	39	16	substitutions	substitution	NNS
cord-326257-rcv8sh22	39	17	was	be	VBD
cord-326257-rcv8sh22	39	18	high	high	JJ
cord-326257-rcv8sh22	39	19	-in	-in	.
cord-326257-rcv8sh22	40	1	the	the	DT
cord-326257-rcv8sh22	40	2	range	range	NN
cord-326257-rcv8sh22	40	3	of	of	IN
cord-326257-rcv8sh22	40	4	0.57	0.57	CD
cord-326257-rcv8sh22	40	5	-	-	HYPH
cord-326257-rcv8sh22	40	6	0.73	0.73	CD
cord-326257-rcv8sh22	40	7	amongst	amongst	IN
cord-326257-rcv8sh22	40	8	the	the	DT
cord-326257-rcv8sh22	40	9	different	different	JJ
cord-326257-rcv8sh22	40	10	SARS	SARS	NNP
cord-326257-rcv8sh22	40	11	-	-	HYPH
cord-326257-rcv8sh22	40	12	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	40	13	datasets	dataset	NNS
cord-326257-rcv8sh22	40	14	.	.	.
cord-326257-rcv8sh22	41	1	This	this	DT
cord-326257-rcv8sh22	41	2	contrasts	contrast	VBZ
cord-326257-rcv8sh22	41	3	with	with	IN
cord-326257-rcv8sh22	41	4	a	a	DT
cord-326257-rcv8sh22	41	5	much	much	RB
cord-326257-rcv8sh22	41	6	lower	low	JJR
cord-326257-rcv8sh22	41	7	ratio	ratio	NN
cord-326257-rcv8sh22	41	8	(	(	-LRB-
cord-326257-rcv8sh22	41	9	consistently	consistently	RB
cord-326257-rcv8sh22	41	10	below	below	IN
cord-326257-rcv8sh22	41	11	<	<	XX
cord-326257-rcv8sh22	41	12	0.22	0.22	CD
cord-326257-rcv8sh22	41	13	)	)	-RRB-
cord-326257-rcv8sh22	41	14	in	in	IN
cord-326257-rcv8sh22	41	15	sequence	sequence	NN
cord-326257-rcv8sh22	41	16	datasets	dataset	NNS
cord-326257-rcv8sh22	41	17	85	85	CD
cord-326257-rcv8sh22	41	18	assembled	assemble	VBN
cord-326257-rcv8sh22	41	19	for	for	IN
cord-326257-rcv8sh22	41	20	the	the	DT
cord-326257-rcv8sh22	41	21	other	other	JJ
cord-326257-rcv8sh22	41	22	human	human	JJ
cord-326257-rcv8sh22	41	23	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	41	24	(	(	-LRB-
cord-326257-rcv8sh22	41	25	Table	table	NN
cord-326257-rcv8sh22	41	26	1	1	CD
cord-326257-rcv8sh22	41	27	)	)	-RRB-
cord-326257-rcv8sh22	41	28	.	.	.
cord-326257-rcv8sh22	42	1	Including	include	VBG
cord-326257-rcv8sh22	42	2	a	a	DT
cord-326257-rcv8sh22	42	3	range	range	NN
cord-326257-rcv8sh22	42	4	of	of	IN
cord-326257-rcv8sh22	42	5	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	42	6	in	in	IN
cord-326257-rcv8sh22	42	7	the	the	DT
cord-326257-rcv8sh22	42	8	analysis	analysis	NN
cord-326257-rcv8sh22	42	9	,	,	,
cord-326257-rcv8sh22	42	10	there	there	EX
cord-326257-rcv8sh22	42	11	was	be	VBD
cord-326257-rcv8sh22	42	12	a	a	DT
cord-326257-rcv8sh22	42	13	consistent	consistent	JJ
cord-326257-rcv8sh22	42	14	association	association	NN
cord-326257-rcv8sh22	42	15	between	between	IN
cord-326257-rcv8sh22	42	16	dN	dN	NNP
cord-326257-rcv8sh22	42	17	/	/	SYM
cord-326257-rcv8sh22	42	18	dS	dS	NNP
cord-326257-rcv8sh22	42	19	with	with	IN
cord-326257-rcv8sh22	42	20	degree	degree	NN
cord-326257-rcv8sh22	42	21	of	of	IN
cord-326257-rcv8sh22	42	22	sequence	sequence	NN
cord-326257-rcv8sh22	42	23	divergence	divergence	NN
cord-326257-rcv8sh22	42	24	(	(	-LRB-
cord-326257-rcv8sh22	42	25	Fig	fig	NN
cord-326257-rcv8sh22	42	26	.	.	.
cord-326257-rcv8sh22	42	27	  	  	_SP
cord-326257-rcv8sh22	42	28	1	1	CD
cord-326257-rcv8sh22	42	29	)	)	-RRB-
cord-326257-rcv8sh22	42	30	.	.	.
cord-326257-rcv8sh22	43	1	We	-PRON-	PRP
cord-326257-rcv8sh22	43	2	next	next	RB
cord-326257-rcv8sh22	43	3	estimated	estimate	VBN
cord-326257-rcv8sh22	43	4	frequencies	frequency	NNS
cord-326257-rcv8sh22	43	5	of	of	IN
cord-326257-rcv8sh22	43	6	individual	individual	JJ
cord-326257-rcv8sh22	43	7	transitions	transition	NNS
cord-326257-rcv8sh22	43	8	and	and	CC
cord-326257-rcv8sh22	43	9	transversions	transversion	NNS
cord-326257-rcv8sh22	43	10	occurring	occur	VBG
cord-326257-rcv8sh22	43	11	during	during	IN
cord-326257-rcv8sh22	43	12	the	the	DT
cord-326257-rcv8sh22	43	13	short-90	short-90	NN
cord-326257-rcv8sh22	43	14	terms	term	NNS
cord-326257-rcv8sh22	43	15	evolution	evolution	NN
cord-326257-rcv8sh22	43	16	of	of	IN
cord-326257-rcv8sh22	43	17	SARS	SARS	NNP
cord-326257-rcv8sh22	43	18	-	-	HYPH
cord-326257-rcv8sh22	43	19	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	43	20	.	.	.
cord-326257-rcv8sh22	44	1	Sequence	sequence	NN
cord-326257-rcv8sh22	44	2	differences	difference	NNS
cord-326257-rcv8sh22	44	3	between	between	IN
cord-326257-rcv8sh22	44	4	each	each	DT
cord-326257-rcv8sh22	44	5	SARS	SARS	NNP
cord-326257-rcv8sh22	44	6	-	-	HYPH
cord-326257-rcv8sh22	44	7	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	44	8	full	full	JJ
cord-326257-rcv8sh22	44	9	genome	genome	NN
cord-326257-rcv8sh22	44	10	sequence	sequence	NN
cord-326257-rcv8sh22	44	11	and	and	CC
cord-326257-rcv8sh22	44	12	a	a	DT
cord-326257-rcv8sh22	44	13	majority	majority	NN
cord-326257-rcv8sh22	44	14	rule	rule	NN
cord-326257-rcv8sh22	44	15	consensus	consensus	NN
cord-326257-rcv8sh22	44	16	sequence	sequence	NN
cord-326257-rcv8sh22	44	17	generated	generate	VBN
cord-326257-rcv8sh22	44	18	for	for	IN
cord-326257-rcv8sh22	44	19	each	each	DT
cord-326257-rcv8sh22	44	20	of	of	IN
cord-326257-rcv8sh22	44	21	the	the	DT
cord-326257-rcv8sh22	44	22	four	four	CD
cord-326257-rcv8sh22	44	23	SARS	SARS	NNP
cord-326257-rcv8sh22	44	24	-	-	HYPH
cord-326257-rcv8sh22	44	25	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	44	26	datasets	dataset	NNS
cord-326257-rcv8sh22	44	27	were	be	VBD
cord-326257-rcv8sh22	44	28	calculated	calculate	VBN
cord-326257-rcv8sh22	44	29	.	.	.
cord-326257-rcv8sh22	45	1	The	the	DT
cord-326257-rcv8sh22	45	2	directionality	directionality	NN
cord-326257-rcv8sh22	45	3	of	of	IN
cord-326257-rcv8sh22	45	4	sequence	sequence	NN
cord-326257-rcv8sh22	45	5	change	change	NN
cord-326257-rcv8sh22	45	6	underlying	underlie	VBG
cord-326257-rcv8sh22	45	7	the	the	DT
cord-326257-rcv8sh22	45	8	observed	observed	JJ
cord-326257-rcv8sh22	45	9	substitutions	substitution	NNS
cord-326257-rcv8sh22	45	10	was	be	VBD
cord-326257-rcv8sh22	45	11	inferred	infer	VBN
cord-326257-rcv8sh22	45	12	through	through	IN
cord-326257-rcv8sh22	45	13	restricting	restrict	VBG
cord-326257-rcv8sh22	45	14	analysis	analysis	NN
cord-326257-rcv8sh22	45	15	to	to	IN
cord-326257-rcv8sh22	45	16	polymorphic	polymorphic	JJ
cord-326257-rcv8sh22	45	17	sites	site	NNS
cord-326257-rcv8sh22	45	18	with	with	IN
cord-326257-rcv8sh22	45	19	a	a	DT
cord-326257-rcv8sh22	45	20	minimal	minimal	JJ
cord-326257-rcv8sh22	45	21	number	number	NN
cord-326257-rcv8sh22	45	22	of	of	IN
cord-326257-rcv8sh22	45	23	variable	variable	JJ
cord-326257-rcv8sh22	45	24	bases	basis	NNS
cord-326257-rcv8sh22	45	25	(	(	-LRB-
cord-326257-rcv8sh22	45	26	typically	typically	RB
cord-326257-rcv8sh22	45	27	singletons	singleton	NNS
cord-326257-rcv8sh22	45	28	)	)	-RRB-
cord-326257-rcv8sh22	45	29	.	.	.
cord-326257-rcv8sh22	46	1	In	in	IN
cord-326257-rcv8sh22	46	2	practice	practice	NN
cord-326257-rcv8sh22	46	3	because	because	IN
cord-326257-rcv8sh22	46	4	of	of	IN
cord-326257-rcv8sh22	46	5	the	the	DT
cord-326257-rcv8sh22	46	6	scarcity	scarcity	NN
cord-326257-rcv8sh22	46	7	of	of	IN
cord-326257-rcv8sh22	46	8	substitutions	substitution	NNS
cord-326257-rcv8sh22	46	9	,	,	,
cord-326257-rcv8sh22	46	10	variability	variability	NN
cord-326257-rcv8sh22	46	11	thresholds	threshold	NNS
cord-326257-rcv8sh22	46	12	of	of	IN
cord-326257-rcv8sh22	46	13	10	10	CD
cord-326257-rcv8sh22	46	14	%	%	NN
cord-326257-rcv8sh22	46	15	,	,	,
cord-326257-rcv8sh22	46	16	95	95	CD
cord-326257-rcv8sh22	46	17	5	5	CD
cord-326257-rcv8sh22	46	18	%	%	NN
cord-326257-rcv8sh22	46	19	,	,	,
cord-326257-rcv8sh22	46	20	2	2	CD
cord-326257-rcv8sh22	46	21	%	%	NN
cord-326257-rcv8sh22	46	22	and	and	CC
cord-326257-rcv8sh22	46	23	1	1	CD
cord-326257-rcv8sh22	46	24	%	%	NN
cord-326257-rcv8sh22	46	25	yielded	yield	VBD
cord-326257-rcv8sh22	46	26	similar	similar	JJ
cord-326257-rcv8sh22	46	27	numbers	number	NNS
cord-326257-rcv8sh22	46	28	and	and	CC
cord-326257-rcv8sh22	46	29	relative	relative	JJ
cord-326257-rcv8sh22	46	30	frequencies	frequency	NNS
cord-326257-rcv8sh22	46	31	of	of	IN
cord-326257-rcv8sh22	46	32	each	each	DT
cord-326257-rcv8sh22	46	33	transition	transition	NN
cord-326257-rcv8sh22	46	34	and	and	CC
cord-326257-rcv8sh22	46	35	transversion	transversion	NN
cord-326257-rcv8sh22	46	36	.	.	.
cord-326257-rcv8sh22	47	1	Equivalent	equivalent	JJ
cord-326257-rcv8sh22	47	2	evidence	evidence	NN
cord-326257-rcv8sh22	47	3	for	for	IN
cord-326257-rcv8sh22	47	4	directionality	directionality	NN
cord-326257-rcv8sh22	47	5	was	be	VBD
cord-326257-rcv8sh22	47	6	obtained	obtain	VBN
cord-326257-rcv8sh22	47	7	through	through	IN
cord-326257-rcv8sh22	47	8	comparison	comparison	NN
cord-326257-rcv8sh22	47	9	of	of	IN
cord-326257-rcv8sh22	47	10	each	each	DT
cord-326257-rcv8sh22	47	11	sequence	sequence	NN
cord-326257-rcv8sh22	47	12	in	in	IN
cord-326257-rcv8sh22	47	13	the	the	DT
cord-326257-rcv8sh22	47	14	dataset	dataset	NN
cord-326257-rcv8sh22	47	15	with	with	IN
cord-326257-rcv8sh22	47	16	the	the	DT
cord-326257-rcv8sh22	47	17	first	first	JJ
cord-326257-rcv8sh22	47	18	outbreak	outbreak	NN
cord-326257-rcv8sh22	47	19	sequence	sequence	NN
cord-326257-rcv8sh22	47	20	(	(	-LRB-
cord-326257-rcv8sh22	47	21	MN908947	MN908947	NNP
cord-326257-rcv8sh22	47	22	;	;	:
cord-326257-rcv8sh22	47	23	Wuhan	Wuhan	NNP
cord-326257-rcv8sh22	47	24	-	-	HYPH
cord-326257-rcv8sh22	47	25	Hu-1	Hu-1	NNP
cord-326257-rcv8sh22	47	26	)	)	-RRB-
cord-326257-rcv8sh22	47	27	,	,	,
cord-326257-rcv8sh22	47	28	approximately	approximately	RB
cord-326257-rcv8sh22	47	29	ancestral	ancestral	JJ
cord-326257-rcv8sh22	47	30	to	to	TO
cord-326257-rcv8sh22	47	31	current	current	JJ
cord-326257-rcv8sh22	47	32	circulating	circulate	VBG
cord-326257-rcv8sh22	47	33	SARS	SARS	NNP
cord-326257-rcv8sh22	47	34	-	-	HYPH
cord-326257-rcv8sh22	47	35	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	47	36	strains	strain	NNS
cord-326257-rcv8sh22	47	37	(	(	-LRB-
cord-326257-rcv8sh22	47	38	data	datum	NNS
cord-326257-rcv8sh22	47	39	not	not	RB
cord-326257-rcv8sh22	47	40	shown	show	VBN
cord-326257-rcv8sh22	47	41	)	)	-RRB-
cord-326257-rcv8sh22	47	42	.	.	.
cord-326257-rcv8sh22	48	1	For	for	IN
cord-326257-rcv8sh22	48	2	the	the	DT
cord-326257-rcv8sh22	48	3	purposes	purpose	NNS
cord-326257-rcv8sh22	48	4	of	of	IN
cord-326257-rcv8sh22	48	5	the	the	DT
cord-326257-rcv8sh22	48	6	analysis	analysis	NN
cord-326257-rcv8sh22	48	7	presented	present	VBN
cord-326257-rcv8sh22	48	8	here	here	RB
cord-326257-rcv8sh22	48	9	,	,	,
cord-326257-rcv8sh22	48	10	a	a	DT
cord-326257-rcv8sh22	48	11	consensus	consensus	NN
cord-326257-rcv8sh22	48	12	-	-	HYPH
cord-326257-rcv8sh22	48	13	based	base	VBN
cord-326257-rcv8sh22	48	14	5	5	CD
cord-326257-rcv8sh22	48	15	%	%	NN
cord-326257-rcv8sh22	48	16	threshold	threshold	NN
cord-326257-rcv8sh22	48	17	was	be	VBD
cord-326257-rcv8sh22	48	18	used	use	VBN
cord-326257-rcv8sh22	48	19	.	.	.
cord-326257-rcv8sh22	49	1	100	100	CD
cord-326257-rcv8sh22	50	1	A	a	DT
cord-326257-rcv8sh22	50	2	listing	listing	NN
cord-326257-rcv8sh22	50	3	of	of	IN
cord-326257-rcv8sh22	50	4	the	the	DT
cord-326257-rcv8sh22	50	5	sequence	sequence	NN
cord-326257-rcv8sh22	50	6	changes	change	NNS
cord-326257-rcv8sh22	50	7	revealed	reveal	VBD
cord-326257-rcv8sh22	50	8	a	a	DT
cord-326257-rcv8sh22	50	9	striking	strike	VBG
cord-326257-rcv8sh22	50	10	(	(	-LRB-
cord-326257-rcv8sh22	50	11	approximately	approximately	RB
cord-326257-rcv8sh22	50	12	four	four	CD
cord-326257-rcv8sh22	50	13	-	-	RB
cord-326257-rcv8sh22	50	14	fold	fold	JJ
cord-326257-rcv8sh22	50	15	)	)	-RRB-
cord-326257-rcv8sh22	50	16	excess	excess	NN
cord-326257-rcv8sh22	50	17	of	of	IN
cord-326257-rcv8sh22	50	18	sites	site	NNS
cord-326257-rcv8sh22	50	19	where	where	WRB
cord-326257-rcv8sh22	50	20	C->U	c->u	NN
cord-326257-rcv8sh22	50	21	substitutions	substitution	NNS
cord-326257-rcv8sh22	50	22	occurred	occur	VBD
cord-326257-rcv8sh22	50	23	in	in	IN
cord-326257-rcv8sh22	50	24	SARS	SARS	NNP
cord-326257-rcv8sh22	50	25	-	-	HYPH
cord-326257-rcv8sh22	50	26	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	50	27	sequences	sequence	NNS
cord-326257-rcv8sh22	50	28	compared	compare	VBN
cord-326257-rcv8sh22	50	29	to	to	IN
cord-326257-rcv8sh22	50	30	the	the	DT
cord-326257-rcv8sh22	50	31	other	other	JJ
cord-326257-rcv8sh22	50	32	three	three	CD
cord-326257-rcv8sh22	50	33	transitions	transition	NNS
cord-326257-rcv8sh22	50	34	(	(	-LRB-
cord-326257-rcv8sh22	50	35	Fig	fig	NN
cord-326257-rcv8sh22	50	36	.	.	.
cord-326257-rcv8sh22	50	37	  	  	_SP
cord-326257-rcv8sh22	50	38	2A	2a	CD
cord-326257-rcv8sh22	50	39	)	)	-RRB-
cord-326257-rcv8sh22	50	40	.	.	.
cord-326257-rcv8sh22	51	1	This	this	DT
cord-326257-rcv8sh22	51	2	excess	excess	NN
cord-326257-rcv8sh22	51	3	was	be	VBD
cord-326257-rcv8sh22	51	4	the	the	DT
cord-326257-rcv8sh22	51	5	more	more	RBR
cord-326257-rcv8sh22	51	6	remarkable	remarkable	JJ
cord-326257-rcv8sh22	51	7	given	give	VBN
cord-326257-rcv8sh22	52	1	there	there	EX
cord-326257-rcv8sh22	52	2	was	be	VBD
cord-326257-rcv8sh22	52	3	an	an	DT
cord-326257-rcv8sh22	52	4	almost	almost	RB
cord-326257-rcv8sh22	52	5	two	two	CD
cord-326257-rcv8sh22	52	6	-	-	HYPH
cord-326257-rcv8sh22	52	7	fold	fold	VB
cord-326257-rcv8sh22	52	8	greater	great	JJR
cord-326257-rcv8sh22	52	9	number	number	NN
cord-326257-rcv8sh22	52	10	of	of	IN
cord-326257-rcv8sh22	52	11	U	U	NNP
cord-326257-rcv8sh22	52	12	bases	basis	NNS
cord-326257-rcv8sh22	52	13	in	in	IN
cord-326257-rcv8sh22	52	14	the	the	DT
cord-326257-rcv8sh22	52	15	SARS	SARS	NNP
cord-326257-rcv8sh22	52	16	-	-	HYPH
cord-326257-rcv8sh22	52	17	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	52	18	genome	genome	NN
cord-326257-rcv8sh22	52	19	compared	compare	VBN
cord-326257-rcv8sh22	52	20	to	to	IN
cord-326257-rcv8sh22	52	21	C	C	NNP
cord-326257-rcv8sh22	52	22	's	's	POS
cord-326257-rcv8sh22	52	23	(	(	-LRB-
cord-326257-rcv8sh22	52	24	32.1	32.1	CD
cord-326257-rcv8sh22	52	25	%	%	NN
cord-326257-rcv8sh22	52	26	compared	compare	VBN
cord-326257-rcv8sh22	52	27	to	to	IN
cord-326257-rcv8sh22	52	28	18.4	18.4	CD
cord-326257-rcv8sh22	52	29	%	%	NN
cord-326257-rcv8sh22	52	30	)	)	-RRB-
cord-326257-rcv8sh22	52	31	.	.	.
cord-326257-rcv8sh22	53	1	To	to	TO
cord-326257-rcv8sh22	53	2	formally	formally	RB
cord-326257-rcv8sh22	53	3	analyse	analyse	VB
cord-326257-rcv8sh22	53	4	105	105	CD
cord-326257-rcv8sh22	53	5	the	the	DT
cord-326257-rcv8sh22	53	6	excess	excess	NN
cord-326257-rcv8sh22	53	7	of	of	IN
cord-326257-rcv8sh22	53	8	C->U	c->u	NN
cord-326257-rcv8sh22	53	9	transitions	transition	NNS
cord-326257-rcv8sh22	53	10	we	-PRON-	PRP
cord-326257-rcv8sh22	53	11	calculated	calculate	VBD
cord-326257-rcv8sh22	53	12	an	an	DT
cord-326257-rcv8sh22	53	13	index	index	NN
cord-326257-rcv8sh22	53	14	of	of	IN
cord-326257-rcv8sh22	53	15	asymmetry	asymmetry	NN
cord-326257-rcv8sh22	54	1	(	(	-LRB-
cord-326257-rcv8sh22	54	2	frequency[C->U	frequency[C->U	NNP
cord-326257-rcv8sh22	54	3	]	]	-RRB-
cord-326257-rcv8sh22	54	4	/	/	SYM
cord-326257-rcv8sh22	54	5	f[U->C	f[U->C	NNP
cord-326257-rcv8sh22	54	6	]	]	-RRB-
cord-326257-rcv8sh22	54	7	)	)	-RRB-
cord-326257-rcv8sh22	55	1	x	x	LS
cord-326257-rcv8sh22	56	1	(	(	-LRB-
cord-326257-rcv8sh22	56	2	fU	fU	NNP
cord-326257-rcv8sh22	56	3	/	/	,
cord-326257-rcv8sh22	56	4	fC	fc	NN
cord-326257-rcv8sh22	56	5	)	)	-RRB-
cord-326257-rcv8sh22	57	1	and	and	CC
cord-326257-rcv8sh22	57	2	compared	compare	VBN
cord-326257-rcv8sh22	57	3	this	this	DT
cord-326257-rcv8sh22	57	4	with	with	IN
cord-326257-rcv8sh22	57	5	degrees	degree	NNS
cord-326257-rcv8sh22	57	6	of	of	IN
cord-326257-rcv8sh22	57	7	sequence	sequence	NN
cord-326257-rcv8sh22	57	8	divergence	divergence	NN
cord-326257-rcv8sh22	57	9	and	and	CC
cord-326257-rcv8sh22	57	10	dN	dN	NNP
cord-326257-rcv8sh22	57	11	/	/	SYM
cord-326257-rcv8sh22	57	12	dS	dS	NNP
cord-326257-rcv8sh22	57	13	ratio	ratio	NN
cord-326257-rcv8sh22	57	14	in	in	IN
cord-326257-rcv8sh22	57	15	SARS	SARS	NNP
cord-326257-rcv8sh22	57	16	-	-	HYPH
cord-326257-rcv8sh22	57	17	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	57	18	and	and	CC
cord-326257-rcv8sh22	57	19	other	other	JJ
cord-326257-rcv8sh22	57	20	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	57	21	datasets	dataset	NNS
cord-326257-rcv8sh22	57	22	(	(	-LRB-
cord-326257-rcv8sh22	57	23	Fig	Fig	NNP
cord-326257-rcv8sh22	57	24	.	.	.
cord-326257-rcv8sh22	57	25	2B	2B	NNP
cord-326257-rcv8sh22	57	26	,	,	,
cord-326257-rcv8sh22	57	27	2C	2C	NNP
cord-326257-rcv8sh22	57	28	)	)	-RRB-
cord-326257-rcv8sh22	57	29	.	.	.
cord-326257-rcv8sh22	58	1	This	this	DT
cord-326257-rcv8sh22	58	2	comparison	comparison	NN
cord-326257-rcv8sh22	58	3	showed	show	VBD
cord-326257-rcv8sh22	58	4	that	that	IN
cord-326257-rcv8sh22	58	5	the	the	DT
cord-326257-rcv8sh22	58	6	excess	excess	NN
cord-326257-rcv8sh22	58	7	of	of	IN
cord-326257-rcv8sh22	58	8	C->U	c->u	NN
cord-326257-rcv8sh22	58	9	substitutions	substitution	NNS
cord-326257-rcv8sh22	58	10	was	be	VBD
cord-326257-rcv8sh22	58	11	most	most	RBS
cord-326257-rcv8sh22	58	12	marked	mark	VBN
cord-326257-rcv8sh22	58	13	among	among	IN
cord-326257-rcv8sh22	58	14	very	very	RB
cord-326257-rcv8sh22	58	15	recently	recently	RB
cord-326257-rcv8sh22	58	16	diverged	diverge	VBN
cord-326257-rcv8sh22	58	17	sequences	sequence	NNS
cord-326257-rcv8sh22	58	18	associated	associate	VBN
cord-326257-rcv8sh22	58	19	with	with	IN
cord-326257-rcv8sh22	58	20	the	the	DT
cord-326257-rcv8sh22	58	21	SARS	SARS	NNP
cord-326257-rcv8sh22	58	22	-	-	HYPH
cord-326257-rcv8sh22	58	23	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	58	24	and	and	CC
cord-326257-rcv8sh22	58	25	SARS	SARS	NNP
cord-326257-rcv8sh22	58	26	-	-	HYPH
cord-326257-rcv8sh22	58	27	CoV	CoV	NNP
cord-326257-rcv8sh22	58	28	outbreaks	outbreak	NNS
cord-326257-rcv8sh22	58	29	and	and	CC
cord-326257-rcv8sh22	58	30	was	be	VBD
cord-326257-rcv8sh22	58	31	reduced	reduce	VBN
cord-326257-rcv8sh22	58	32	significantly	significantly	RB
cord-326257-rcv8sh22	58	33	in	in	IN
cord-326257-rcv8sh22	58	34	sequence	sequence	NN
cord-326257-rcv8sh22	58	35	datasets	dataset	NNS
cord-326257-rcv8sh22	58	36	of	of	IN
cord-326257-rcv8sh22	58	37	the	the	DT
cord-326257-rcv8sh22	58	38	more	more	RBR
cord-326257-rcv8sh22	58	39	divergent	divergent	JJ
cord-326257-rcv8sh22	58	40	human	human	NN
cord-326257-rcv8sh22	58	41	110	110	CD
cord-326257-rcv8sh22	58	42	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	58	43	(	(	-LRB-
cord-326257-rcv8sh22	58	44	NL63	NL63	NNP
cord-326257-rcv8sh22	58	45	,	,	,
cord-326257-rcv8sh22	58	46	OC43	OC43	NNP
cord-326257-rcv8sh22	58	47	,	,	,
cord-326257-rcv8sh22	58	48	229E	229e	CD
cord-326257-rcv8sh22	58	49	and	and	CC
cord-326257-rcv8sh22	58	50	OC43	OC43	NNP
cord-326257-rcv8sh22	58	51	)	)	-RRB-
cord-326257-rcv8sh22	58	52	datasets	dataset	NNS
cord-326257-rcv8sh22	58	53	as	as	IN
cord-326257-rcv8sh22	58	54	sequences	sequence	NNS
cord-326257-rcv8sh22	58	55	accumulated	accumulate	VBN
cord-326257-rcv8sh22	58	56	substitutions	substitution	NNS
cord-326257-rcv8sh22	58	57	.	.	.
cord-326257-rcv8sh22	59	1	C->U	c->u	NN
cord-326257-rcv8sh22	59	2	substitutions	substitution	NNS
cord-326257-rcv8sh22	59	3	were	be	VBD
cord-326257-rcv8sh22	59	4	scattered	scatter	VBN
cord-326257-rcv8sh22	59	5	throughout	throughout	IN
cord-326257-rcv8sh22	59	6	the	the	DT
cord-326257-rcv8sh22	59	7	SARS	SARS	NNP
cord-326257-rcv8sh22	59	8	-	-	HYPH
cord-326257-rcv8sh22	59	9	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	59	10	genome	genome	NN
cord-326257-rcv8sh22	59	11	(	(	-LRB-
cord-326257-rcv8sh22	59	12	Fig	Fig	NNP
cord-326257-rcv8sh22	59	13	.	.	.
cord-326257-rcv8sh22	59	14	3	3	CD
cord-326257-rcv8sh22	59	15	)	)	-RRB-
cord-326257-rcv8sh22	59	16	.	.	.
cord-326257-rcv8sh22	60	1	Long	long	JJ
cord-326257-rcv8sh22	60	2	bars	bar	NNS
cord-326257-rcv8sh22	60	3	representing	represent	VBG
cord-326257-rcv8sh22	60	4	more	more	RBR
cord-326257-rcv8sh22	60	5	polymorphic	polymorphic	JJ
cord-326257-rcv8sh22	60	6	sites	site	NNS
cord-326257-rcv8sh22	60	7	were	be	VBD
cord-326257-rcv8sh22	60	8	frequently	frequently	RB
cord-326257-rcv8sh22	60	9	shared	share	VBN
cord-326257-rcv8sh22	60	10	between	between	IN
cord-326257-rcv8sh22	60	11	replicate	replicate	VB
cord-326257-rcv8sh22	60	12	datasets	dataset	NNS
cord-326257-rcv8sh22	60	13	but	but	CC
cord-326257-rcv8sh22	60	14	unique	unique	JJ
cord-326257-rcv8sh22	60	15	substitutions	substitution	NNS
cord-326257-rcv8sh22	60	16	(	(	-LRB-
cord-326257-rcv8sh22	60	17	occurring	occur	VBG
cord-326257-rcv8sh22	60	18	once	once	RB
cord-326257-rcv8sh22	60	19	in	in	IN
cord-326257-rcv8sh22	60	20	the	the	DT
cord-326257-rcv8sh22	60	21	dataset	dataset	NN
cord-326257-rcv8sh22	60	22	-short	-short	NN
cord-326257-rcv8sh22	60	23	bars	bar	NNS
cord-326257-rcv8sh22	60	24	)	)	-RRB-
cord-326257-rcv8sh22	60	25	showed	show	VBD
cord-326257-rcv8sh22	60	26	largely	largely	RB
cord-326257-rcv8sh22	60	27	separate	separate	JJ
cord-326257-rcv8sh22	60	28	distributions	distribution	NNS
cord-326257-rcv8sh22	60	29	.	.	.
cord-326257-rcv8sh22	61	1	Substitutions	substitution	NNS
cord-326257-rcv8sh22	61	2	were	be	VBD
cord-326257-rcv8sh22	61	3	115	115	CD
cord-326257-rcv8sh22	61	4	not	not	RB
cord-326257-rcv8sh22	61	5	focussed	focusse	VBN
cord-326257-rcv8sh22	61	6	towards	towards	IN
cord-326257-rcv8sh22	61	7	any	any	DT
cord-326257-rcv8sh22	61	8	particular	particular	JJ
cord-326257-rcv8sh22	61	9	gene	gene	NN
cord-326257-rcv8sh22	61	10	or	or	CC
cord-326257-rcv8sh22	61	11	intergenic	intergenic	JJ
cord-326257-rcv8sh22	61	12	region	region	NN
cord-326257-rcv8sh22	61	13	although	although	IN
cord-326257-rcv8sh22	61	14	all	all	DT
cord-326257-rcv8sh22	61	15	three	three	CD
cord-326257-rcv8sh22	61	16	datasets	dataset	NNS
cord-326257-rcv8sh22	61	17	showed	show	VBD
cord-326257-rcv8sh22	61	18	marginally	marginally	RB
cord-326257-rcv8sh22	61	19	higher	high	JJR
cord-326257-rcv8sh22	61	20	frequencies	frequency	NNS
cord-326257-rcv8sh22	61	21	of	of	IN
cord-326257-rcv8sh22	61	22	substitutions	substitution	NNS
cord-326257-rcv8sh22	61	23	in	in	IN
cord-326257-rcv8sh22	61	24	the	the	DT
cord-326257-rcv8sh22	61	25	N	n	CD
cord-326257-rcv8sh22	61	26	gene	gene	NN
cord-326257-rcv8sh22	61	27	.	.	.
cord-326257-rcv8sh22	62	1	The	the	DT
cord-326257-rcv8sh22	62	2	grouping	grouping	NN
cord-326257-rcv8sh22	62	3	of	of	IN
cord-326257-rcv8sh22	62	4	a	a	DT
cord-326257-rcv8sh22	62	5	selection	selection	NN
cord-326257-rcv8sh22	62	6	of	of	IN
cord-326257-rcv8sh22	62	7	sequences	sequence	NNS
cord-326257-rcv8sh22	62	8	showing	show	VBG
cord-326257-rcv8sh22	62	9	C->U	c->u	NN
cord-326257-rcv8sh22	62	10	changes	change	NNS
cord-326257-rcv8sh22	62	11	in	in	IN
cord-326257-rcv8sh22	62	12	different	different	JJ
cord-326257-rcv8sh22	62	13	genome	genome	NN
cord-326257-rcv8sh22	62	14	regions	region	NNS
cord-326257-rcv8sh22	62	15	were	be	VBD
cord-326257-rcv8sh22	62	16	plotted	plot	VBN
cord-326257-rcv8sh22	62	17	in	in	IN
cord-326257-rcv8sh22	62	18	a	a	DT
cord-326257-rcv8sh22	62	19	phylogenetic	phylogenetic	JJ
cord-326257-rcv8sh22	62	20	tree	tree	NN
cord-326257-rcv8sh22	62	21	containing	contain	VBG
cord-326257-rcv8sh22	62	22	sequences	sequence	NNS
cord-326257-rcv8sh22	62	23	from	from	IN
cord-326257-rcv8sh22	62	24	the	the	DT
cord-326257-rcv8sh22	62	25	SARS	SARS	NNP
cord-326257-rcv8sh22	62	26	-	-	HYPH
cord-326257-rcv8sh22	62	27	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	62	28	dataset	dataset	NN
cord-326257-rcv8sh22	62	29	(	(	-LRB-
cord-326257-rcv8sh22	62	30	Fig	Fig	NNP
cord-326257-rcv8sh22	62	31	.	.	.
cord-326257-rcv8sh22	62	32	4	4	CD
cord-326257-rcv8sh22	62	33	)	)	-RRB-
cord-326257-rcv8sh22	62	34	.	.	.
cord-326257-rcv8sh22	63	1	Within	within	IN
cord-326257-rcv8sh22	63	2	the	the	DT
cord-326257-rcv8sh22	63	3	resolution	resolution	NN
cord-326257-rcv8sh22	63	4	possible	possible	JJ
cord-326257-rcv8sh22	63	5	in	in	IN
cord-326257-rcv8sh22	63	6	tree	tree	NN
cord-326257-rcv8sh22	63	7	generated	generate	VBN
cord-326257-rcv8sh22	63	8	from	from	IN
cord-326257-rcv8sh22	63	9	such	such	PDT
cord-326257-rcv8sh22	63	10	a	a	DT
cord-326257-rcv8sh22	63	11	minimally	minimally	RB
cord-326257-rcv8sh22	63	12	divergent	divergent	JJ
cord-326257-rcv8sh22	63	13	dataset	dataset	NN
cord-326257-rcv8sh22	63	14	,	,	,
cord-326257-rcv8sh22	63	15	many	many	JJ
cord-326257-rcv8sh22	63	16	sequences	sequence	NNS
cord-326257-rcv8sh22	63	17	with	with	IN
cord-326257-rcv8sh22	63	18	shared	share	VBN
cord-326257-rcv8sh22	63	19	C	C	NNP
cord-326257-rcv8sh22	63	20	-	-	HYPH
cord-326257-rcv8sh22	63	21	U	U	NNP
cord-326257-rcv8sh22	63	22	changes	change	NNS
cord-326257-rcv8sh22	63	23	were	be	VBD
cord-326257-rcv8sh22	63	24	not	not	RB
cord-326257-rcv8sh22	63	25	monophyletic	monophyletic	JJ
cord-326257-rcv8sh22	63	26	120	120	CD
cord-326257-rcv8sh22	64	1	(	(	-LRB-
cord-326257-rcv8sh22	64	2	eg	eg	IN
cord-326257-rcv8sh22	64	3	.	.	.
cord-326257-rcv8sh22	65	1	those	those	DT
cord-326257-rcv8sh22	65	2	with	with	IN
cord-326257-rcv8sh22	65	3	substitutions	substitution	NNS
cord-326257-rcv8sh22	65	4	at	at	IN
cord-326257-rcv8sh22	65	5	positions	position	NNS
cord-326257-rcv8sh22	65	6	5784	5784	CD
cord-326257-rcv8sh22	65	7	,	,	,
cord-326257-rcv8sh22	65	8	10319	10319	CD
cord-326257-rcv8sh22	65	9	,	,	,
cord-326257-rcv8sh22	65	10	21575	21575	CD
cord-326257-rcv8sh22	65	11	,	,	,
cord-326257-rcv8sh22	65	12	28657	28657	CD
cord-326257-rcv8sh22	65	13	and	and	CC
cord-326257-rcv8sh22	65	14	28887	28887	CD
cord-326257-rcv8sh22	65	15	)	)	-RRB-
cord-326257-rcv8sh22	65	16	.	.	.
cord-326257-rcv8sh22	66	1	This	this	DT
cord-326257-rcv8sh22	66	2	lack	lack	NN
cord-326257-rcv8sh22	66	3	of	of	IN
cord-326257-rcv8sh22	66	4	grouping	grouping	NN
cord-326257-rcv8sh22	66	5	is	be	VBZ
cord-326257-rcv8sh22	66	6	consistent	consistent	JJ
cord-326257-rcv8sh22	66	7	with	with	IN
cord-326257-rcv8sh22	66	8	multiple	multiple	JJ
cord-326257-rcv8sh22	66	9	de	de	FW
cord-326257-rcv8sh22	66	10	novo	novo	JJ
cord-326257-rcv8sh22	66	11	occurrences	occurrence	NNS
cord-326257-rcv8sh22	66	12	of	of	IN
cord-326257-rcv8sh22	66	13	the	the	DT
cord-326257-rcv8sh22	66	14	same	same	JJ
cord-326257-rcv8sh22	66	15	mutation	mutation	NN
cord-326257-rcv8sh22	66	16	in	in	IN
cord-326257-rcv8sh22	66	17	different	different	JJ
cord-326257-rcv8sh22	66	18	SARS	SARS	NNP
cord-326257-rcv8sh22	66	19	-	-	HYPH
cord-326257-rcv8sh22	66	20	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	66	21	lineages	lineage	NNS
cord-326257-rcv8sh22	66	22	.	.	.
cord-326257-rcv8sh22	67	1	The	the	DT
cord-326257-rcv8sh22	67	2	abnormally	abnormally	RB
cord-326257-rcv8sh22	67	3	high	high	JJ
cord-326257-rcv8sh22	67	4	dN	dN	NNP
cord-326257-rcv8sh22	67	5	/	/	SYM
cord-326257-rcv8sh22	67	6	dS	dS	NNP
cord-326257-rcv8sh22	67	7	ratios	ratio	NNS
cord-326257-rcv8sh22	67	8	of	of	IN
cord-326257-rcv8sh22	67	9	0.6	0.6	CD
cord-326257-rcv8sh22	67	10	-	-	SYM
cord-326257-rcv8sh22	67	11	0.7	0.7	CD
cord-326257-rcv8sh22	67	12	in	in	IN
cord-326257-rcv8sh22	67	13	SARS	SARS	NNP
cord-326257-rcv8sh22	67	14	-	-	HYPH
cord-326257-rcv8sh22	67	15	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	67	16	sequences	sequence	NNS
cord-326257-rcv8sh22	67	17	(	(	-LRB-
cord-326257-rcv8sh22	67	18	Table	table	NN
cord-326257-rcv8sh22	67	19	1	1	CD
cord-326257-rcv8sh22	67	20	;	;	:
cord-326257-rcv8sh22	67	21	Fig	fig	NN
cord-326257-rcv8sh22	67	22	.	.	NNP
cord-326257-rcv8sh22	67	23	1	1	CD
cord-326257-rcv8sh22	67	24	)	)	-RRB-
cord-326257-rcv8sh22	67	25	indicated	indicate	VBD
cord-326257-rcv8sh22	67	26	that	that	IN
cord-326257-rcv8sh22	67	27	125	125	CD
cord-326257-rcv8sh22	67	28	around	around	IN
cord-326257-rcv8sh22	67	29	50	50	CD
cord-326257-rcv8sh22	67	30	%	%	NN
cord-326257-rcv8sh22	67	31	of	of	IN
cord-326257-rcv8sh22	67	32	nucleotide	nucleotide	JJ
cord-326257-rcv8sh22	67	33	substitutions	substitution	NNS
cord-326257-rcv8sh22	67	34	would	would	MD
cord-326257-rcv8sh22	67	35	produce	produce	VB
cord-326257-rcv8sh22	67	36	amino	amino	NN
cord-326257-rcv8sh22	67	37	acid	acid	NN
cord-326257-rcv8sh22	67	38	changes	change	NNS
cord-326257-rcv8sh22	67	39	(	(	-LRB-
cord-326257-rcv8sh22	67	40	if	if	IN
cord-326257-rcv8sh22	67	41	approximately	approximately	RB
cord-326257-rcv8sh22	67	42	75	75	CD
cord-326257-rcv8sh22	67	43	%	%	NN
cord-326257-rcv8sh22	67	44	of	of	IN
cord-326257-rcv8sh22	67	45	nucleotide	nucleotide	JJ
cord-326257-rcv8sh22	67	46	changes	change	NNS
cord-326257-rcv8sh22	67	47	are	be	VBP
cord-326257-rcv8sh22	67	48	non	non	JJ
cord-326257-rcv8sh22	67	49	-	-	JJ
cord-326257-rcv8sh22	67	50	synonymous	synonymous	JJ
cord-326257-rcv8sh22	67	51	)	)	-RRB-
cord-326257-rcv8sh22	67	52	.	.	.
cord-326257-rcv8sh22	68	1	On	on	IN
cord-326257-rcv8sh22	68	2	analysis	analysis	NN
cord-326257-rcv8sh22	68	3	of	of	IN
cord-326257-rcv8sh22	68	4	amino	amino	NN
cord-326257-rcv8sh22	68	5	acid	acid	NN
cord-326257-rcv8sh22	68	6	sequence	sequence	NN
cord-326257-rcv8sh22	68	7	changes	change	NNS
cord-326257-rcv8sh22	68	8	,	,	,
cord-326257-rcv8sh22	68	9	a	a	DT
cord-326257-rcv8sh22	68	10	remarkable	remarkable	JJ
cord-326257-rcv8sh22	68	11	50	50	CD
cord-326257-rcv8sh22	68	12	%	%	NN
cord-326257-rcv8sh22	68	13	of	of	IN
cord-326257-rcv8sh22	68	14	non	non	JJ
cord-326257-rcv8sh22	68	15	-	-	JJ
cord-326257-rcv8sh22	68	16	synonymous	synonymous	JJ
cord-326257-rcv8sh22	68	17	substitutions	substitution	NNS
cord-326257-rcv8sh22	68	18	in	in	IN
cord-326257-rcv8sh22	68	19	the	the	DT
cord-326257-rcv8sh22	68	20	SARS	SARS	NNP
cord-326257-rcv8sh22	68	21	-	-	HYPH
cord-326257-rcv8sh22	68	22	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	68	23	sequence	sequence	NN
cord-326257-rcv8sh22	68	24	dataset	dataset	NN
cord-326257-rcv8sh22	68	25	were	be	VBD
cord-326257-rcv8sh22	68	26	the	the	DT
cord-326257-rcv8sh22	68	27	consequence	consequence	NN
cord-326257-rcv8sh22	68	28	of	of	IN
cord-326257-rcv8sh22	68	29	C->U	c->u	NN
cord-326257-rcv8sh22	68	30	transitions	transition	NNS
cord-326257-rcv8sh22	68	31	(	(	-LRB-
cord-326257-rcv8sh22	68	32	Fig	fig	NN
cord-326257-rcv8sh22	68	33	.	.	NNP
cord-326257-rcv8sh22	68	34	5	5	CD
cord-326257-rcv8sh22	68	35	)	)	-RRB-
cord-326257-rcv8sh22	68	36	.	.	.
cord-326257-rcv8sh22	69	1	The	the	DT
cord-326257-rcv8sh22	69	2	underlying	underlying	JJ
cord-326257-rcv8sh22	69	3	mechanism	mechanism	NN
cord-326257-rcv8sh22	69	4	that	that	WDT
cord-326257-rcv8sh22	69	5	leads	lead	VBZ
cord-326257-rcv8sh22	69	6	to	to	IN
cord-326257-rcv8sh22	69	7	C->U	c->u	NN
cord-326257-rcv8sh22	69	8	hypermutation	hypermutation	NN
cord-326257-rcv8sh22	69	9	therefore	therefore	RB
cord-326257-rcv8sh22	69	10	also	also	RB
cord-326257-rcv8sh22	69	11	drives	drive	VBZ
cord-326257-rcv8sh22	69	12	much	much	JJ
cord-326257-rcv8sh22	69	13	of	of	IN
cord-326257-rcv8sh22	69	14	the	the	DT
cord-326257-rcv8sh22	69	15	amino	amino	NN
cord-326257-rcv8sh22	69	16	acid	acid	NN
cord-326257-rcv8sh22	69	17	sequence	sequence	NN
cord-326257-rcv8sh22	69	18	diversity	diversity	NN
cord-326257-rcv8sh22	69	19	observed	observe	VBN
cord-326257-rcv8sh22	69	20	in	in	IN
cord-326257-rcv8sh22	69	21	SARS	SARS	NNP
cord-326257-rcv8sh22	69	22	-	-	HYPH
cord-326257-rcv8sh22	69	23	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	69	24	.	.	.
cord-326257-rcv8sh22	70	1	130	130	CD
cord-326257-rcv8sh22	71	1	The	the	DT
cord-326257-rcv8sh22	71	2	context	context	NN
cord-326257-rcv8sh22	71	3	of	of	IN
cord-326257-rcv8sh22	71	4	cytidines	cytidine	NNS
cord-326257-rcv8sh22	71	5	within	within	IN
cord-326257-rcv8sh22	71	6	a	a	DT
cord-326257-rcv8sh22	71	7	sequence	sequence	NN
cord-326257-rcv8sh22	71	8	strongly	strongly	RB
cord-326257-rcv8sh22	71	9	influenced	influence	VBD
cord-326257-rcv8sh22	71	10	the	the	DT
cord-326257-rcv8sh22	71	11	likelihood	likelihood	NN
cord-326257-rcv8sh22	71	12	of	of	IN
cord-326257-rcv8sh22	71	13	it	-PRON-	PRP
cord-326257-rcv8sh22	71	14	mutating	mutate	VBG
cord-326257-rcv8sh22	71	15	to	to	IN
cord-326257-rcv8sh22	71	16	a	a	DT
cord-326257-rcv8sh22	71	17	U	u	NN
cord-326257-rcv8sh22	71	18	(	(	-LRB-
cord-326257-rcv8sh22	71	19	Fig	fig	NN
cord-326257-rcv8sh22	71	20	.	.	.
cord-326257-rcv8sh22	71	21	  	  	_SP
cord-326257-rcv8sh22	71	22	6	6	CD
cord-326257-rcv8sh22	71	23	)	)	-RRB-
cord-326257-rcv8sh22	71	24	.	.	.
cord-326257-rcv8sh22	72	1	The	the	DT
cord-326257-rcv8sh22	72	2	greatest	great	JJS
cord-326257-rcv8sh22	72	3	numbers	number	NNS
cord-326257-rcv8sh22	72	4	of	of	IN
cord-326257-rcv8sh22	72	5	mutations	mutation	NNS
cord-326257-rcv8sh22	72	6	were	be	VBD
cord-326257-rcv8sh22	72	7	observed	observe	VBN
cord-326257-rcv8sh22	72	8	if	if	IN
cord-326257-rcv8sh22	72	9	the	the	DT
cord-326257-rcv8sh22	72	10	upstream	upstream	NN
cord-326257-rcv8sh22	72	11	(	(	-LRB-
cord-326257-rcv8sh22	72	12	5	5	CD
cord-326257-rcv8sh22	72	13	'	'	''
cord-326257-rcv8sh22	72	14	)	)	-RRB-
cord-326257-rcv8sh22	72	15	base	base	NN
cord-326257-rcv8sh22	72	16	was	be	VBD
cord-326257-rcv8sh22	72	17	an	an	DT
cord-326257-rcv8sh22	72	18	A	a	NN
cord-326257-rcv8sh22	72	19	or	or	CC
cord-326257-rcv8sh22	73	1	U.	U.	NNP
cord-326257-rcv8sh22	73	2	There	there	EX
cord-326257-rcv8sh22	73	3	was	be	VBD
cord-326257-rcv8sh22	73	4	also	also	RB
cord-326257-rcv8sh22	73	5	a	a	DT
cord-326257-rcv8sh22	73	6	similar	similar	JJ
cord-326257-rcv8sh22	73	7	approximately	approximately	RB
cord-326257-rcv8sh22	73	8	4-fold	4-fold	CD
cord-326257-rcv8sh22	73	9	increase	increase	NN
cord-326257-rcv8sh22	73	10	in	in	IN
cord-326257-rcv8sh22	73	11	transitions	transition	NNS
cord-326257-rcv8sh22	73	12	if	if	IN
cord-326257-rcv8sh22	73	13	these	these	DT
cord-326257-rcv8sh22	73	14	bases	basis	NNS
cord-326257-rcv8sh22	73	15	were	be	VBD
cord-326257-rcv8sh22	73	16	located	locate	VBN
cord-326257-rcv8sh22	73	17	on	on	IN
cord-326257-rcv8sh22	73	18	the	the	DT
cord-326257-rcv8sh22	73	19	downstream	downstream	NN
cord-326257-rcv8sh22	73	20	(	(	-LRB-
cord-326257-rcv8sh22	73	21	3	3	CD
cord-326257-rcv8sh22	73	22	'	'	''
cord-326257-rcv8sh22	73	23	)	)	-RRB-
cord-326257-rcv8sh22	73	24	side	side	NN
cord-326257-rcv8sh22	73	25	.	.	.
cord-326257-rcv8sh22	74	1	The	the	DT
cord-326257-rcv8sh22	74	2	effects	effect	NNS
cord-326257-rcv8sh22	74	3	of	of	IN
cord-326257-rcv8sh22	74	4	the	the	DT
cord-326257-rcv8sh22	74	5	5	5	CD
cord-326257-rcv8sh22	74	6	'	'	''
cord-326257-rcv8sh22	74	7	and	and	CC
cord-326257-rcv8sh22	74	8	3	3	CD
cord-326257-rcv8sh22	74	9	'	'	''
cord-326257-rcv8sh22	74	10	contexts	context	NNS
cord-326257-rcv8sh22	74	11	were	be	VBD
cord-326257-rcv8sh22	74	12	additive	additive	NN
cord-326257-rcv8sh22	74	13	;	;	:
cord-326257-rcv8sh22	74	14	C	c	NN
cord-326257-rcv8sh22	74	15	residues	residue	NNS
cord-326257-rcv8sh22	74	16	surrounded	surround	VBN
cord-326257-rcv8sh22	74	17	by	by	IN
cord-326257-rcv8sh22	74	18	135	135	CD
cord-326257-rcv8sh22	74	19	an	an	DT
cord-326257-rcv8sh22	74	20	A	a	NN
cord-326257-rcv8sh22	74	21	or	or	CC
cord-326257-rcv8sh22	74	22	U	u	NN
cord-326257-rcv8sh22	74	23	at	at	IN
cord-326257-rcv8sh22	74	24	both	both	DT
cord-326257-rcv8sh22	74	25	5	5	CD
cord-326257-rcv8sh22	74	26	'	'	''
cord-326257-rcv8sh22	74	27	and	and	CC
cord-326257-rcv8sh22	75	1	3	3	LS
cord-326257-rcv8sh22	75	2	'	'	POS
cord-326257-rcv8sh22	75	3	sides	side	NNS
cord-326257-rcv8sh22	75	4	were	be	VBD
cord-326257-rcv8sh22	75	5	10-fold	10-fold	JJ
cord-326257-rcv8sh22	75	6	more	more	RBR
cord-326257-rcv8sh22	75	7	likely	likely	JJ
cord-326257-rcv8sh22	75	8	to	to	TO
cord-326257-rcv8sh22	75	9	mutate	mutate	VB
cord-326257-rcv8sh22	75	10	than	than	IN
cord-326257-rcv8sh22	75	11	those	those	DT
cord-326257-rcv8sh22	75	12	flanked	flank	VBN
cord-326257-rcv8sh22	75	13	by	by	IN
cord-326257-rcv8sh22	75	14	C	C	NNP
cord-326257-rcv8sh22	75	15	or	or	CC
cord-326257-rcv8sh22	75	16	G	g	NN
cord-326257-rcv8sh22	75	17	residues	residue	NNS
cord-326257-rcv8sh22	75	18	(	(	-LRB-
cord-326257-rcv8sh22	75	19	mean	mean	VB
cord-326257-rcv8sh22	75	20	31.9	31.9	CD
cord-326257-rcv8sh22	75	21	transitions	transition	NNS
cord-326257-rcv8sh22	75	22	compared	compare	VBN
cord-326257-rcv8sh22	75	23	to	to	IN
cord-326257-rcv8sh22	75	24	3.6	3.6	CD
cord-326257-rcv8sh22	75	25	)	)	-RRB-
cord-326257-rcv8sh22	75	26	.	.	.
cord-326257-rcv8sh22	76	1	Splitting	split	VBG
cord-326257-rcv8sh22	76	2	the	the	DT
cord-326257-rcv8sh22	76	3	data	datum	NNS
cord-326257-rcv8sh22	76	4	down	down	RP
cord-326257-rcv8sh22	76	5	into	into	IN
cord-326257-rcv8sh22	76	6	the	the	DT
cord-326257-rcv8sh22	76	7	16	16	CD
cord-326257-rcv8sh22	76	8	combinations	combination	NNS
cord-326257-rcv8sh22	76	9	of	of	IN
cord-326257-rcv8sh22	76	10	5	5	CD
cord-326257-rcv8sh22	76	11	'	'	''
cord-326257-rcv8sh22	76	12	and	and	CC
cord-326257-rcv8sh22	76	13	3	3	CD
cord-326257-rcv8sh22	76	14	'	'	''
cord-326257-rcv8sh22	76	15	contexts	context	NNS
cord-326257-rcv8sh22	76	16	,	,	,
cord-326257-rcv8sh22	76	17	a	a	DT
cord-326257-rcv8sh22	76	18	5'U	5'u	CD
cord-326257-rcv8sh22	76	19	far	far	RB
cord-326257-rcv8sh22	76	20	more	more	RBR
cord-326257-rcv8sh22	76	21	potently	potently	RB
cord-326257-rcv8sh22	76	22	restricted	restricted	JJ
cord-326257-rcv8sh22	76	23	non	non	JJ
cord-326257-rcv8sh22	76	24	-	-	JJ
cord-326257-rcv8sh22	76	25	C->U	c->u	JJ
cord-326257-rcv8sh22	76	26	substitutions	substitution	NNS
cord-326257-rcv8sh22	76	27	than	than	IN
cord-326257-rcv8sh22	76	28	a	a	DT
cord-326257-rcv8sh22	76	29	5'A	5'a	CD
cord-326257-rcv8sh22	76	30	(	(	-LRB-
cord-326257-rcv8sh22	76	31	Fig	fig	NN
cord-326257-rcv8sh22	76	32	.	.	.
cord-326257-rcv8sh22	76	33	S1	s1	NN
cord-326257-rcv8sh22	76	34	;	;	:
cord-326257-rcv8sh22	76	35	Suppl	Suppl	NNP
cord-326257-rcv8sh22	76	36	.	.	.
cord-326257-rcv8sh22	77	1	Data	datum	NNS
cord-326257-rcv8sh22	77	2	)	)	-RRB-
cord-326257-rcv8sh22	77	3	,	,	,
cord-326257-rcv8sh22	77	4	while	while	IN
cord-326257-rcv8sh22	77	5	5'G	5'g	CD
cord-326257-rcv8sh22	77	6	or	or	CC
cord-326257-rcv8sh22	77	7	5'C	5'c	NN
cord-326257-rcv8sh22	77	8	almost	almost	RB
cord-326257-rcv8sh22	77	9	eliminated	eliminate	VBN
cord-326257-rcv8sh22	77	10	substitutions	substitution	NNS
cord-326257-rcv8sh22	77	11	irrespective	irrespective	RB
cord-326257-rcv8sh22	77	12	of	of	IN
cord-326257-rcv8sh22	77	13	the	the	DT
cord-326257-rcv8sh22	77	14	3	3	CD
cord-326257-rcv8sh22	77	15	'	'	''
cord-326257-rcv8sh22	77	16	context	context	NN
cord-326257-rcv8sh22	77	17	.	.	.
cord-326257-rcv8sh22	78	1	No	no	DT
cord-326257-rcv8sh22	78	2	context	context	NN
cord-326257-rcv8sh22	78	3	created	create	VBD
cord-326257-rcv8sh22	78	4	any	any	DT
cord-326257-rcv8sh22	78	5	substantial	substantial	JJ
cord-326257-rcv8sh22	78	6	asymmetry	asymmetry	NN
cord-326257-rcv8sh22	78	7	in	in	IN
cord-326257-rcv8sh22	78	8	G->A	G->A	NNP
cord-326257-rcv8sh22	78	9	compared	compare	VBN
cord-326257-rcv8sh22	78	10	to	to	IN
cord-326257-rcv8sh22	78	11	A->G	A->G	NNP
cord-326257-rcv8sh22	78	12	transitions	transition	NNS
cord-326257-rcv8sh22	78	13	.	.	.
cord-326257-rcv8sh22	79	1	The	the	DT
cord-326257-rcv8sh22	79	2	G+C	G+C	NNP
cord-326257-rcv8sh22	79	3	content	content	NN
cord-326257-rcv8sh22	79	4	of	of	IN
cord-326257-rcv8sh22	79	5	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	79	6	varied	vary	VBN
cord-326257-rcv8sh22	79	7	substantially	substantially	RB
cord-326257-rcv8sh22	79	8	between	between	IN
cord-326257-rcv8sh22	79	9	species	specie	NNS
cord-326257-rcv8sh22	79	10	,	,	,
cord-326257-rcv8sh22	79	11	with	with	IN
cord-326257-rcv8sh22	79	12	highest	high	JJS
cord-326257-rcv8sh22	79	13	frequencies	frequency	NNS
cord-326257-rcv8sh22	79	14	in	in	IN
cord-326257-rcv8sh22	79	15	the	the	DT
cord-326257-rcv8sh22	79	16	recently	recently	RB
cord-326257-rcv8sh22	79	17	emerged	emerge	VBN
cord-326257-rcv8sh22	79	18	zoonotic	zoonotic	JJ
cord-326257-rcv8sh22	79	19	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	79	20	(	(	-LRB-
cord-326257-rcv8sh22	79	21	MERS	MERS	NNP
cord-326257-rcv8sh22	79	22	-	-	HYPH
cord-326257-rcv8sh22	79	23	CoV	CoV	NNP
cord-326257-rcv8sh22	79	24	:	:	:
cord-326257-rcv8sh22	79	25	41	41	CD
cord-326257-rcv8sh22	79	26	%	%	NN
cord-326257-rcv8sh22	79	27	,	,	,
cord-326257-rcv8sh22	79	28	SARS	SARS	NNP
cord-326257-rcv8sh22	79	29	-	-	HYPH
cord-326257-rcv8sh22	79	30	CoV	CoV	NNP
cord-326257-rcv8sh22	79	31	:	:	:
cord-326257-rcv8sh22	79	32	41	41	CD
cord-326257-rcv8sh22	79	33	%	%	NN
cord-326257-rcv8sh22	79	34	and	and	CC
cord-326257-rcv8sh22	79	35	SARS	SARS	NNP
cord-326257-rcv8sh22	79	36	-	-	HYPH
cord-326257-rcv8sh22	79	37	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	79	38	:	:	:
cord-326257-rcv8sh22	79	39	38	38	CD
cord-326257-rcv8sh22	79	40	%	%	NN
cord-326257-rcv8sh22	79	41	)	)	-RRB-
cord-326257-rcv8sh22	79	42	and	and	CC
cord-326257-rcv8sh22	79	43	lowest	low	JJS
cord-326257-rcv8sh22	79	44	in	in	IN
cord-326257-rcv8sh22	79	45	HKU1	HKU1	NNP
cord-326257-rcv8sh22	79	46	(	(	-LRB-
cord-326257-rcv8sh22	79	47	32	32	CD
cord-326257-rcv8sh22	79	48	%	%	NN
cord-326257-rcv8sh22	79	49	)	)	-RRB-
cord-326257-rcv8sh22	79	50	.	.	.
cord-326257-rcv8sh22	80	1	Collectively	collectively	RB
cord-326257-rcv8sh22	80	2	,	,	,
cord-326257-rcv8sh22	80	3	there	there	EX
cord-326257-rcv8sh22	80	4	was	be	VBD
cord-326257-rcv8sh22	80	5	a	a	DT
cord-326257-rcv8sh22	80	6	significant	significant	JJ
cord-326257-rcv8sh22	80	7	relationship	relationship	NN
cord-326257-rcv8sh22	80	8	between	between	IN
cord-326257-rcv8sh22	80	9	C	c	NN
cord-326257-rcv8sh22	80	10	depletion	depletion	NN
cord-326257-rcv8sh22	80	11	and	and	CC
cord-326257-rcv8sh22	80	12	U	u	NN
cord-326257-rcv8sh22	80	13	enrichment	enrichment	NN
cord-326257-rcv8sh22	80	14	with	with	IN
cord-326257-rcv8sh22	80	15	G+C	G+C	NNP
cord-326257-rcv8sh22	80	16	content	content	NN
cord-326257-rcv8sh22	81	1	(	(	-LRB-
cord-326257-rcv8sh22	81	2	Fig	Fig	NNP
cord-326257-rcv8sh22	81	3	.	.	NNP
cord-326257-rcv8sh22	81	4	7	7	CD
cord-326257-rcv8sh22	81	5	)	)	-RRB-
cord-326257-rcv8sh22	81	6	.	.	.
cord-326257-rcv8sh22	82	1	The	the	DT
cord-326257-rcv8sh22	82	2	difference	difference	NN
cord-326257-rcv8sh22	82	3	in	in	IN
cord-326257-rcv8sh22	82	4	G+C	G+C	NNP
cord-326257-rcv8sh22	82	5	content	content	NN
cord-326257-rcv8sh22	82	6	was	be	VBD
cord-326257-rcv8sh22	82	7	indeed	indeed	RB
cord-326257-rcv8sh22	82	8	almost	almost	RB
cord-326257-rcv8sh22	82	9	entirely	entirely	RB
cord-326257-rcv8sh22	82	10	145	145	CD
cord-326257-rcv8sh22	82	11	attributable	attributable	JJ
cord-326257-rcv8sh22	82	12	to	to	IN
cord-326257-rcv8sh22	82	13	changes	change	NNS
cord-326257-rcv8sh22	82	14	in	in	IN
cord-326257-rcv8sh22	82	15	the	the	DT
cord-326257-rcv8sh22	82	16	frequencies	frequency	NNS
cord-326257-rcv8sh22	82	17	of	of	IN
cord-326257-rcv8sh22	82	18	C	C	NNP
cord-326257-rcv8sh22	82	19	and	and	CC
cord-326257-rcv8sh22	82	20	U	U	NNP
cord-326257-rcv8sh22	82	21	bases	basis	NNS
cord-326257-rcv8sh22	82	22	;	;	:
cord-326257-rcv8sh22	82	23	the	the	DT
cord-326257-rcv8sh22	82	24	9	9	CD
cord-326257-rcv8sh22	82	25	%	%	NN
cord-326257-rcv8sh22	82	26	difference	difference	NN
cord-326257-rcv8sh22	82	27	in	in	IN
cord-326257-rcv8sh22	82	28	G+C	G+C	NNP
cord-326257-rcv8sh22	82	29	content	content	NN
cord-326257-rcv8sh22	82	30	between	between	IN
cord-326257-rcv8sh22	82	31	MERS	MERS	NNP
cord-326257-rcv8sh22	82	32	-	-	HYPH
cord-326257-rcv8sh22	82	33	CoV	CoV	NNP
cord-326257-rcv8sh22	82	34	and	and	CC
cord-326257-rcv8sh22	82	35	HKU1	HKU1	NNP
cord-326257-rcv8sh22	82	36	arose	arise	VBD
cord-326257-rcv8sh22	82	37	primarily	primarily	RB
cord-326257-rcv8sh22	82	38	from	from	IN
cord-326257-rcv8sh22	82	39	the	the	DT
cord-326257-rcv8sh22	82	40	20	20	CD
cord-326257-rcv8sh22	82	41	%	%	NN
cord-326257-rcv8sh22	82	42	-	-	:
cord-326257-rcv8sh22	82	43	>	>	SYM
cord-326257-rcv8sh22	82	44	13	13	CD
cord-326257-rcv8sh22	82	45	%	%	NN
cord-326257-rcv8sh22	82	46	reduction	reduction	NN
cord-326257-rcv8sh22	82	47	in	in	IN
cord-326257-rcv8sh22	82	48	frequencies	frequency	NNS
cord-326257-rcv8sh22	82	49	of	of	IN
cord-326257-rcv8sh22	82	50	C.	C.	NNP
cord-326257-rcv8sh22	83	1	There	there	EX
cord-326257-rcv8sh22	83	2	was	be	VBD
cord-326257-rcv8sh22	83	3	a	a	DT
cord-326257-rcv8sh22	83	4	comparable	comparable	JJ
cord-326257-rcv8sh22	83	5	8	8	CD
cord-326257-rcv8sh22	83	6	%	%	NN
cord-326257-rcv8sh22	83	7	increase	increase	NN
cord-326257-rcv8sh22	83	8	in	in	IN
cord-326257-rcv8sh22	83	9	the	the	DT
cord-326257-rcv8sh22	83	10	frequency	frequency	NN
cord-326257-rcv8sh22	83	11	of	of	IN
cord-326257-rcv8sh22	83	12	U.	U.	NNP
cord-326257-rcv8sh22	83	13	Their	-PRON-	PRP$
cord-326257-rcv8sh22	83	14	combined	combine	VBN
cord-326257-rcv8sh22	83	15	effects	effect	NNS
cord-326257-rcv8sh22	83	16	left	leave	VBD
cord-326257-rcv8sh22	83	17	frequencies	frequency	NNS
cord-326257-rcv8sh22	83	18	of	of	IN
cord-326257-rcv8sh22	83	19	G	g	NN
cord-326257-rcv8sh22	83	20	and	and	CC
cord-326257-rcv8sh22	83	21	A	a	DT
cord-326257-rcv8sh22	83	22	relatively	relatively	RB
cord-326257-rcv8sh22	83	23	unchanged	unchanged	JJ
cord-326257-rcv8sh22	83	24	.	.	.
cord-326257-rcv8sh22	84	1	It	-PRON-	PRP
cord-326257-rcv8sh22	84	2	appears	appear	VBZ
cord-326257-rcv8sh22	84	3	that	that	IN
cord-326257-rcv8sh22	84	4	the	the	DT
cord-326257-rcv8sh22	84	5	accumulated	accumulate	VBN
cord-326257-rcv8sh22	84	6	effect	effect	NN
cord-326257-rcv8sh22	84	7	of	of	IN
cord-326257-rcv8sh22	84	8	the	the	DT
cord-326257-rcv8sh22	84	9	C->U	C->U	NNP
cord-326257-rcv8sh22	84	10	/	/	SYM
cord-326257-rcv8sh22	84	11	U->C	U->C	NNP
cord-326257-rcv8sh22	84	12	asymmetry	asymmetry	NN
cord-326257-rcv8sh22	84	13	led	lead	VBD
cord-326257-rcv8sh22	84	14	to	to	IN
cord-326257-rcv8sh22	84	15	marked	mark	VBN
cord-326257-rcv8sh22	84	16	compositional	compositional	JJ
cord-326257-rcv8sh22	84	17	abnormalities	abnormality	NNS
cord-326257-rcv8sh22	84	18	in	in	IN
cord-326257-rcv8sh22	84	19	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	84	20	.	.	.
cord-326257-rcv8sh22	85	1	150	150	CD
cord-326257-rcv8sh22	86	1	The	the	DT
cord-326257-rcv8sh22	86	2	wealth	wealth	NN
cord-326257-rcv8sh22	86	3	of	of	IN
cord-326257-rcv8sh22	86	4	sequence	sequence	NN
cord-326257-rcv8sh22	86	5	data	datum	NNS
cord-326257-rcv8sh22	86	6	generated	generate	VBN
cord-326257-rcv8sh22	86	7	since	since	IN
cord-326257-rcv8sh22	86	8	the	the	DT
cord-326257-rcv8sh22	86	9	outset	outset	NN
cord-326257-rcv8sh22	86	10	of	of	IN
cord-326257-rcv8sh22	86	11	the	the	DT
cord-326257-rcv8sh22	86	12	SARS	SARS	NNP
cord-326257-rcv8sh22	86	13	-	-	HYPH
cord-326257-rcv8sh22	86	14	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	86	15	pandemic	pandemic	NN
cord-326257-rcv8sh22	86	16	,	,	,
cord-326257-rcv8sh22	86	17	the	the	DT
cord-326257-rcv8sh22	86	18	accuracy	accuracy	NN
cord-326257-rcv8sh22	86	19	of	of	IN
cord-326257-rcv8sh22	86	20	the	the	DT
cord-326257-rcv8sh22	86	21	sequences	sequence	NNS
cord-326257-rcv8sh22	86	22	obtained	obtain	VBN
cord-326257-rcv8sh22	86	23	by	by	IN
cord-326257-rcv8sh22	86	24	a	a	DT
cord-326257-rcv8sh22	86	25	range	range	NN
cord-326257-rcv8sh22	86	26	of	of	IN
cord-326257-rcv8sh22	86	27	NGS	NGS	NNP
cord-326257-rcv8sh22	86	28	technologies	technology	NNS
cord-326257-rcv8sh22	86	29	and	and	CC
cord-326257-rcv8sh22	86	30	the	the	DT
cord-326257-rcv8sh22	86	31	long	long	JJ
cord-326257-rcv8sh22	86	32	genomes	genome	NNS
cord-326257-rcv8sh22	86	33	and	and	CC
cord-326257-rcv8sh22	86	34	very	very	RB
cord-326257-rcv8sh22	86	35	low	low	JJ
cord-326257-rcv8sh22	86	36	substitution	substitution	NN
cord-326257-rcv8sh22	86	37	rate	rate	NN
cord-326257-rcv8sh22	86	38	of	of	IN
cord-326257-rcv8sh22	86	39	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	86	40	provided	provide	VBD
cord-326257-rcv8sh22	86	41	a	a	DT
cord-326257-rcv8sh22	86	42	unique	unique	JJ
cord-326257-rcv8sh22	86	43	opportunity	opportunity	NN
cord-326257-rcv8sh22	86	44	to	to	TO
cord-326257-rcv8sh22	86	45	investigate	investigate	VB
cord-326257-rcv8sh22	86	46	sequence	sequence	NN
cord-326257-rcv8sh22	86	47	diversification	diversification	NN
cord-326257-rcv8sh22	86	48	at	at	IN
cord-326257-rcv8sh22	86	49	very	very	RB
cord-326257-rcv8sh22	86	50	high	high	JJ
cord-326257-rcv8sh22	86	51	resolution	resolution	NN
cord-326257-rcv8sh22	86	52	.	.	.
cord-326257-rcv8sh22	87	1	The	the	DT
cord-326257-rcv8sh22	87	2	findings	finding	NNS
cord-326257-rcv8sh22	87	3	additionally	additionally	RB
cord-326257-rcv8sh22	87	4	provide	provide	VBP
cord-326257-rcv8sh22	87	5	insights	insight	NNS
cord-326257-rcv8sh22	87	6	into	into	IN
cord-326257-rcv8sh22	87	7	the	the	DT
cord-326257-rcv8sh22	87	8	mutational	mutational	JJ
cord-326257-rcv8sh22	87	9	mechanisms	mechanism	NNS
cord-326257-rcv8sh22	87	10	and	and	CC
cord-326257-rcv8sh22	87	11	contexts	context	NNS
cord-326257-rcv8sh22	87	12	where	where	WRB
cord-326257-rcv8sh22	87	13	sequence	sequence	NN
cord-326257-rcv8sh22	87	14	changes	change	NNS
cord-326257-rcv8sh22	87	15	occur	occur	VBP
cord-326257-rcv8sh22	87	16	.	.	.
cord-326257-rcv8sh22	88	1	Thirdly	thirdly	RB
cord-326257-rcv8sh22	88	2	,	,	,
cord-326257-rcv8sh22	88	3	it	-PRON-	PRP
cord-326257-rcv8sh22	88	4	informs	inform	VBZ
cord-326257-rcv8sh22	88	5	us	-PRON-	PRP
cord-326257-rcv8sh22	88	6	about	about	IN
cord-326257-rcv8sh22	88	7	the	the	DT
cord-326257-rcv8sh22	88	8	longer	long	JJR
cord-326257-rcv8sh22	88	9	term	term	NN
cord-326257-rcv8sh22	88	10	160	160	CD
cord-326257-rcv8sh22	88	11	evolution	evolution	NN
cord-326257-rcv8sh22	88	12	of	of	IN
cord-326257-rcv8sh22	88	13	viruses	virus	NNS
cord-326257-rcv8sh22	88	14	and	and	CC
cord-326257-rcv8sh22	88	15	potential	potential	JJ
cord-326257-rcv8sh22	88	16	effects	effect	NNS
cord-326257-rcv8sh22	88	17	of	of	IN
cord-326257-rcv8sh22	88	18	the	the	DT
cord-326257-rcv8sh22	88	19	cell	cell	NN
cord-326257-rcv8sh22	88	20	in	in	IN
cord-326257-rcv8sh22	88	21	moulding	moulding	NN
cord-326257-rcv8sh22	88	22	virus	virus	NN
cord-326257-rcv8sh22	88	23	composition	composition	NN
cord-326257-rcv8sh22	88	24	.	.	.
cord-326257-rcv8sh22	89	1	The	the	DT
cord-326257-rcv8sh22	89	2	mechanism	mechanism	NN
cord-326257-rcv8sh22	89	3	of	of	IN
cord-326257-rcv8sh22	89	4	SARS	SARS	NNP
cord-326257-rcv8sh22	89	5	-	-	HYPH
cord-326257-rcv8sh22	89	6	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	89	7	hypermutation	hypermutation	NN
cord-326257-rcv8sh22	89	8	.	.	.
cord-326257-rcv8sh22	90	1	The	the	DT
cord-326257-rcv8sh22	90	2	most	most	RBS
cord-326257-rcv8sh22	90	3	striking	striking	JJ
cord-326257-rcv8sh22	90	4	finding	finding	NN
cord-326257-rcv8sh22	90	5	that	that	WDT
cord-326257-rcv8sh22	90	6	emerged	emerge	VBD
cord-326257-rcv8sh22	90	7	from	from	IN
cord-326257-rcv8sh22	90	8	the	the	DT
cord-326257-rcv8sh22	90	9	analysis	analysis	NN
cord-326257-rcv8sh22	90	10	of	of	IN
cord-326257-rcv8sh22	90	11	more	more	JJR
cord-326257-rcv8sh22	90	12	than	than	IN
cord-326257-rcv8sh22	90	13	1000	1000	CD
cord-326257-rcv8sh22	90	14	SARS	SARS	NNP
cord-326257-rcv8sh22	90	15	-	-	HYPH
cord-326257-rcv8sh22	90	16	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	90	17	genomes	genome	NNS
cord-326257-rcv8sh22	90	18	was	be	VBD
cord-326257-rcv8sh22	90	19	the	the	DT
cord-326257-rcv8sh22	90	20	preponderance	preponderance	NN
cord-326257-rcv8sh22	90	21	of	of	IN
cord-326257-rcv8sh22	90	22	C->U	c->u	NN
cord-326257-rcv8sh22	90	23	transitions	transition	NNS
cord-326257-rcv8sh22	90	24	compared	compare	VBN
cord-326257-rcv8sh22	90	25	to	to	IN
cord-326257-rcv8sh22	90	26	other	other	JJ
cord-326257-rcv8sh22	90	27	substitutions	substitution	NNS
cord-326257-rcv8sh22	90	28	in	in	IN
cord-326257-rcv8sh22	90	29	the	the	DT
cord-326257-rcv8sh22	90	30	initial	initial	JJ
cord-326257-rcv8sh22	90	31	4	4	CD
cord-326257-rcv8sh22	90	32	-	-	SYM
cord-326257-rcv8sh22	90	33	5	5	CD
cord-326257-rcv8sh22	90	34	months	month	NNS
cord-326257-rcv8sh22	90	35	of	of	IN
cord-326257-rcv8sh22	90	36	its	-PRON-	PRP$
cord-326257-rcv8sh22	90	37	evolution	evolution	NN
cord-326257-rcv8sh22	90	38	.	.	.
cord-326257-rcv8sh22	91	1	These	these	DT
cord-326257-rcv8sh22	91	2	accounted	account	VBD
cord-326257-rcv8sh22	91	3	for	for	IN
cord-326257-rcv8sh22	91	4	38%-165	38%-165	CD
cord-326257-rcv8sh22	91	5	42	42	CD
cord-326257-rcv8sh22	91	6	%	%	NN
cord-326257-rcv8sh22	91	7	of	of	IN
cord-326257-rcv8sh22	91	8	all	all	DT
cord-326257-rcv8sh22	91	9	changes	change	NNS
cord-326257-rcv8sh22	91	10	in	in	IN
cord-326257-rcv8sh22	91	11	the	the	DT
cord-326257-rcv8sh22	91	12	four	four	CD
cord-326257-rcv8sh22	91	13	SARS	SARS	NNP
cord-326257-rcv8sh22	91	14	-	-	HYPH
cord-326257-rcv8sh22	91	15	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	91	16	datasets	dataset	NNS
cord-326257-rcv8sh22	91	17	.	.	.
cord-326257-rcv8sh22	92	1	In	in	IN
cord-326257-rcv8sh22	92	2	seeking	seek	VBG
cord-326257-rcv8sh22	92	3	alternative	alternative	NN
cord-326257-rcv8sh22	92	4	,	,	,
cord-326257-rcv8sh22	92	5	non	non	JJ
cord-326257-rcv8sh22	92	6	-	-	JJ
cord-326257-rcv8sh22	92	7	biological	biological	JJ
cord-326257-rcv8sh22	92	8	explanations	explanation	NNS
cord-326257-rcv8sh22	92	9	for	for	IN
cord-326257-rcv8sh22	92	10	this	this	DT
cord-326257-rcv8sh22	92	11	observation	observation	NN
cord-326257-rcv8sh22	92	12	,	,	,
cord-326257-rcv8sh22	92	13	they	-PRON-	PRP
cord-326257-rcv8sh22	92	14	can	can	MD
cord-326257-rcv8sh22	92	15	not	not	RB
cord-326257-rcv8sh22	92	16	have	have	VB
cord-326257-rcv8sh22	92	17	arisen	arise	VBN
cord-326257-rcv8sh22	92	18	through	through	IN
cord-326257-rcv8sh22	92	19	misincorporation	misincorporation	NN
cord-326257-rcv8sh22	92	20	errors	error	NNS
cord-326257-rcv8sh22	92	21	in	in	IN
cord-326257-rcv8sh22	92	22	the	the	DT
cord-326257-rcv8sh22	92	23	next	next	JJ
cord-326257-rcv8sh22	92	24	generation	generation	NN
cord-326257-rcv8sh22	92	25	sequence	sequence	NN
cord-326257-rcv8sh22	92	26	methods	method	NNS
cord-326257-rcv8sh22	92	27	used	use	VBN
cord-326257-rcv8sh22	92	28	to	to	TO
cord-326257-rcv8sh22	92	29	produce	produce	VB
cord-326257-rcv8sh22	92	30	the	the	DT
cord-326257-rcv8sh22	92	31	dataset	dataset	NN
cord-326257-rcv8sh22	92	32	because	because	IN
cord-326257-rcv8sh22	92	33	the	the	DT
cord-326257-rcv8sh22	92	34	analysis	analysis	NN
cord-326257-rcv8sh22	92	35	in	in	IN
cord-326257-rcv8sh22	92	36	the	the	DT
cord-326257-rcv8sh22	92	37	current	current	NN
cord-326257-rcv8sh22	92	38	was	be	VBD
cord-326257-rcv8sh22	92	39	restricted	restrict	VBN
cord-326257-rcv8sh22	92	40	to	to	IN
cord-326257-rcv8sh22	92	41	consensus	consensus	NN
cord-326257-rcv8sh22	92	42	sequences	sequence	NNS
cord-326257-rcv8sh22	92	43	.	.	.
cord-326257-rcv8sh22	93	1	These	these	DT
cord-326257-rcv8sh22	93	2	are	be	VBP
cord-326257-rcv8sh22	93	3	generally	generally	RB
cord-326257-rcv8sh22	93	4	assembled	assemble	VBN
cord-326257-rcv8sh22	93	5	from	from	IN
cord-326257-rcv8sh22	93	6	libraries	library	NNS
cord-326257-rcv8sh22	93	7	that	that	WDT
cord-326257-rcv8sh22	93	8	typically	typically	RB
cord-326257-rcv8sh22	93	9	possess	possess	VBP
cord-326257-rcv8sh22	93	10	reasonable	reasonable	JJ
cord-326257-rcv8sh22	93	11	coverage	coverage	NN
cord-326257-rcv8sh22	93	12	and	and	CC
cord-326257-rcv8sh22	93	13	read	read	VB
cord-326257-rcv8sh22	93	14	depth	depth	NN
cord-326257-rcv8sh22	93	15	;	;	:
cord-326257-rcv8sh22	93	16	error	error	NN
cord-326257-rcv8sh22	93	17	frequencies	frequency	NNS
cord-326257-rcv8sh22	93	18	of	of	IN
cord-326257-rcv8sh22	93	19	<	<	NNP
cord-326257-rcv8sh22	93	20	10	10	CD
cord-326257-rcv8sh22	93	21	-4	-4	NNS
cord-326257-rcv8sh22	93	22	per	per	IN
cord-326257-rcv8sh22	93	23	site	site	NN
cord-326257-rcv8sh22	93	24	(	(	-LRB-
cord-326257-rcv8sh22	93	25	14	14	CD
cord-326257-rcv8sh22	93	26	)	)	-RRB-
cord-326257-rcv8sh22	93	27	would	would	MD
cord-326257-rcv8sh22	93	28	therefore	therefore	RB
cord-326257-rcv8sh22	93	29	improbably	improbably	RB
cord-326257-rcv8sh22	93	30	create	create	VB
cord-326257-rcv8sh22	93	31	170	170	CD
cord-326257-rcv8sh22	93	32	a	a	DT
cord-326257-rcv8sh22	93	33	consensus	consensus	NN
cord-326257-rcv8sh22	93	34	change	change	NN
cord-326257-rcv8sh22	93	35	in	in	IN
cord-326257-rcv8sh22	93	36	a	a	DT
cord-326257-rcv8sh22	93	37	sequence	sequence	NN
cord-326257-rcv8sh22	93	38	library	library	NN
cord-326257-rcv8sh22	93	39	.	.	.
cord-326257-rcv8sh22	94	1	There	there	EX
cord-326257-rcv8sh22	94	2	was	be	VBD
cord-326257-rcv8sh22	94	3	furthermore	furthermore	RB
cord-326257-rcv8sh22	94	4	,	,	,
cord-326257-rcv8sh22	94	5	no	no	DT
cord-326257-rcv8sh22	94	6	comparable	comparable	JJ
cord-326257-rcv8sh22	94	7	increase	increase	NN
cord-326257-rcv8sh22	94	8	in	in	IN
cord-326257-rcv8sh22	94	9	G->A	G->A	NNP
cord-326257-rcv8sh22	94	10	mutations	mutation	NNS
cord-326257-rcv8sh22	94	11	(	(	-LRB-
cord-326257-rcv8sh22	94	12	Fig	Fig	NNP
cord-326257-rcv8sh22	94	13	.	.	NNP
cord-326257-rcv8sh22	94	14	2	2	CD
cord-326257-rcv8sh22	94	15	)	)	-RRB-
cord-326257-rcv8sh22	94	16	and	and	CC
cord-326257-rcv8sh22	94	17	the	the	DT
cord-326257-rcv8sh22	94	18	sequence	sequence	NN
cord-326257-rcv8sh22	94	19	context	context	NN
cord-326257-rcv8sh22	94	20	in	in	IN
cord-326257-rcv8sh22	94	21	which	which	WDT
cord-326257-rcv8sh22	94	22	sequencing	sequencing	NN
cord-326257-rcv8sh22	94	23	errors	error	NNS
cord-326257-rcv8sh22	94	24	occur	occur	VBP
cord-326257-rcv8sh22	94	25	(	(	-LRB-
cord-326257-rcv8sh22	94	26	a	a	DT
cord-326257-rcv8sh22	94	27	5	5	CD
cord-326257-rcv8sh22	94	28	'	'	''
cord-326257-rcv8sh22	94	29	or	or	CC
cord-326257-rcv8sh22	94	30	3	3	CD
cord-326257-rcv8sh22	94	31	'	'	''
cord-326257-rcv8sh22	94	32	C	c	NN
cord-326257-rcv8sh22	94	33	or	or	CC
cord-326257-rcv8sh22	94	34	G	g	NN
cord-326257-rcv8sh22	94	35	;	;	:
cord-326257-rcv8sh22	94	36	(	(	-LRB-
cord-326257-rcv8sh22	94	37	14	14	CD
cord-326257-rcv8sh22	94	38	)	)	-RRB-
cord-326257-rcv8sh22	94	39	)	)	-RRB-
cord-326257-rcv8sh22	94	40	did	do	VBD
cord-326257-rcv8sh22	94	41	not	not	RB
cord-326257-rcv8sh22	94	42	match	match	VB
cord-326257-rcv8sh22	94	43	the	the	DT
cord-326257-rcv8sh22	94	44	favoured	favour	VBN
cord-326257-rcv8sh22	94	45	context	context	NN
cord-326257-rcv8sh22	94	46	for	for	IN
cord-326257-rcv8sh22	94	47	mutation	mutation	NN
cord-326257-rcv8sh22	94	48	observed	observe	VBN
cord-326257-rcv8sh22	94	49	in	in	IN
cord-326257-rcv8sh22	94	50	our	-PRON-	PRP$
cord-326257-rcv8sh22	94	51	dataset	dataset	NN
cord-326257-rcv8sh22	94	52	(	(	-LRB-
cord-326257-rcv8sh22	94	53	Fig	Fig	NNP
cord-326257-rcv8sh22	94	54	.	.	.
cord-326257-rcv8sh22	94	55	6	6	CD
cord-326257-rcv8sh22	94	56	)	)	-RRB-
cord-326257-rcv8sh22	94	57	.	.	.
cord-326257-rcv8sh22	95	1	coronavirus	coronavirus	NNP
cord-326257-rcv8sh22	95	2	RNA	RNA	NNP
cord-326257-rcv8sh22	95	3	dependent	dependent	JJ
cord-326257-rcv8sh22	95	4	RNA	RNA	NNP
cord-326257-rcv8sh22	95	5	polymerase	polymerase	NN
cord-326257-rcv8sh22	95	6	during	during	IN
cord-326257-rcv8sh22	95	7	virus	virus	NN
cord-326257-rcv8sh22	95	8	replication	replication	NN
cord-326257-rcv8sh22	95	9	.	.	.
cord-326257-rcv8sh22	96	1	By	by	IN
cord-326257-rcv8sh22	96	2	definition	definition	NN
cord-326257-rcv8sh22	96	3	,	,	,
cord-326257-rcv8sh22	96	4	a	a	DT
cord-326257-rcv8sh22	96	5	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	96	6	RNA	RNA	NNP
cord-326257-rcv8sh22	96	7	genome	genome	NN
cord-326257-rcv8sh22	96	8	descends	descend	VBZ
cord-326257-rcv8sh22	96	9	from	from	IN
cord-326257-rcv8sh22	96	10	any	any	DT
cord-326257-rcv8sh22	96	11	other	other	JJ
cord-326257-rcv8sh22	96	12	through	through	IN
cord-326257-rcv8sh22	96	13	an	an	DT
cord-326257-rcv8sh22	96	14	equal	equal	JJ
cord-326257-rcv8sh22	96	15	number	number	NN
cord-326257-rcv8sh22	96	16	of	of	IN
cord-326257-rcv8sh22	96	17	copyings	copying	NNS
cord-326257-rcv8sh22	96	18	of	of	IN
cord-326257-rcv8sh22	96	19	the	the	DT
cord-326257-rcv8sh22	96	20	positive	positive	JJ
cord-326257-rcv8sh22	96	21	and	and	CC
cord-326257-rcv8sh22	96	22	negative	negative	JJ
cord-326257-rcv8sh22	96	23	strands	strand	NNS
cord-326257-rcv8sh22	96	24	-any	-any	,
cord-326257-rcv8sh22	96	25	tendency	tendency	NN
cord-326257-rcv8sh22	96	26	to	to	TO
cord-326257-rcv8sh22	96	27	misincorporate	misincorporate	VB
cord-326257-rcv8sh22	96	28	a	a	DT
cord-326257-rcv8sh22	96	29	U	u	NN
cord-326257-rcv8sh22	96	30	instead	instead	RB
cord-326257-rcv8sh22	96	31	of	of	IN
cord-326257-rcv8sh22	96	32	a	a	DT
cord-326257-rcv8sh22	96	33	C	c	NN
cord-326257-rcv8sh22	96	34	would	would	MD
cord-326257-rcv8sh22	96	35	be	be	VB
cord-326257-rcv8sh22	96	36	reflected	reflect	VBN
cord-326257-rcv8sh22	96	37	in	in	IN
cord-326257-rcv8sh22	96	38	a	a	DT
cord-326257-rcv8sh22	96	39	parallel	parallel	JJ
cord-326257-rcv8sh22	96	40	number	number	NN
cord-326257-rcv8sh22	96	41	of	of	IN
cord-326257-rcv8sh22	96	42	G->A	G->A	NNP
cord-326257-rcv8sh22	96	43	mutations	mutation	NNS
cord-326257-rcv8sh22	96	44	where	where	WRB
cord-326257-rcv8sh22	96	45	this	this	DT
cord-326257-rcv8sh22	96	46	error	error	NN
cord-326257-rcv8sh22	96	47	occurred	occur	VBD
cord-326257-rcv8sh22	96	48	on	on	IN
cord-326257-rcv8sh22	96	49	the	the	DT
cord-326257-rcv8sh22	96	50	minus	minus	JJ
cord-326257-rcv8sh22	96	51	strand	strand	NN
cord-326257-rcv8sh22	96	52	(	(	-LRB-
cord-326257-rcv8sh22	96	53	or	or	CC
cord-326257-rcv8sh22	96	54	vice	vice	NN
cord-326257-rcv8sh22	96	55	versa	versa	RB
cord-326257-rcv8sh22	96	56	)	)	-RRB-
cord-326257-rcv8sh22	96	57	.	.	.
cord-326257-rcv8sh22	97	1	As	as	IN
cord-326257-rcv8sh22	97	2	demonstrated	demonstrate	VBN
cord-326257-rcv8sh22	97	3	however	however	RB
cord-326257-rcv8sh22	97	4	,	,	,
cord-326257-rcv8sh22	97	5	G->A	G->A	NNP
cord-326257-rcv8sh22	97	6	mutations	mutation	NNS
cord-326257-rcv8sh22	97	7	occurred	occur	VBD
cord-326257-rcv8sh22	97	8	at	at	IN
cord-326257-rcv8sh22	97	9	a	a	DT
cord-326257-rcv8sh22	97	10	much	much	RB
cord-326257-rcv8sh22	97	11	lower	low	JJR
cord-326257-rcv8sh22	97	12	frequency	frequency	NN
cord-326257-rcv8sh22	97	13	than	than	IN
cord-326257-rcv8sh22	97	14	C->U	c->u	NN
cord-326257-rcv8sh22	97	15	mutations	mutation	NNS
cord-326257-rcv8sh22	97	16	and	and	CC
cord-326257-rcv8sh22	97	17	were	be	VBD
cord-326257-rcv8sh22	97	18	similar	similar	JJ
cord-326257-rcv8sh22	97	19	180	180	CD
cord-326257-rcv8sh22	97	20	to	to	IN
cord-326257-rcv8sh22	97	21	those	those	DT
cord-326257-rcv8sh22	97	22	of	of	IN
cord-326257-rcv8sh22	97	23	A->G	A->G	NNP
cord-326257-rcv8sh22	97	24	(	(	-LRB-
cord-326257-rcv8sh22	97	25	Figs	fig	NNS
cord-326257-rcv8sh22	97	26	.	.	.
cord-326257-rcv8sh22	98	1	2A	2A	NNP
cord-326257-rcv8sh22	98	2	,	,	,
cord-326257-rcv8sh22	98	3	6	6	CD
cord-326257-rcv8sh22	98	4	)	)	-RRB-
cord-326257-rcv8sh22	98	5	.	.	.
cord-326257-rcv8sh22	98	6	 	 	_SP
cord-326257-rcv8sh22	99	1	While	while	IN
cord-326257-rcv8sh22	99	2	deamination	deamination	NN
cord-326257-rcv8sh22	99	3	of	of	IN
cord-326257-rcv8sh22	99	4	cytidines	cytidine	NNS
cord-326257-rcv8sh22	99	5	in	in	IN
cord-326257-rcv8sh22	99	6	single	single	RB
cord-326257-rcv8sh22	99	7	-	-	HYPH
cord-326257-rcv8sh22	99	8	stranded	strand	VBN
cord-326257-rcv8sh22	99	9	DNA	dna	NN
cord-326257-rcv8sh22	99	10	sequences	sequence	NNS
cord-326257-rcv8sh22	99	11	is	be	VBZ
cord-326257-rcv8sh22	99	12	a	a	DT
cord-326257-rcv8sh22	99	13	hallmark	hallmark	NN
cord-326257-rcv8sh22	99	14	of	of	IN
cord-326257-rcv8sh22	99	15	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	99	16	function	function	NN
cord-326257-rcv8sh22	99	17	,	,	,
cord-326257-rcv8sh22	99	18	APOBECs	apobec	NNS
cord-326257-rcv8sh22	99	19	show	show	VBP
cord-326257-rcv8sh22	99	20	binding	bind	VBG
cord-326257-rcv8sh22	99	21	affinities	affinity	NNS
cord-326257-rcv8sh22	99	22	for	for	IN
cord-326257-rcv8sh22	99	23	single	single	JJ
cord-326257-rcv8sh22	99	24	stranded	strand	VBN
cord-326257-rcv8sh22	99	25	RNA	RNA	NNP
cord-326257-rcv8sh22	99	26	templates	template	NNS
cord-326257-rcv8sh22	99	27	that	that	WDT
cord-326257-rcv8sh22	99	28	may	may	MD
cord-326257-rcv8sh22	99	29	mediate	mediate	VB
cord-326257-rcv8sh22	99	30	antiviral	antiviral	JJ
cord-326257-rcv8sh22	99	31	functions	function	NNS
cord-326257-rcv8sh22	99	32	.	.	.
cord-326257-rcv8sh22	100	1	A3B	A3B	NNP
cord-326257-rcv8sh22	100	2	and	and	CC
cord-326257-rcv8sh22	100	3	A3F	a3f	NN
cord-326257-rcv8sh22	100	4	has	have	VBZ
cord-326257-rcv8sh22	100	5	been	be	VBN
cord-326257-rcv8sh22	100	6	shown	show	VBN
cord-326257-rcv8sh22	100	7	to	to	TO
cord-326257-rcv8sh22	100	8	block	block	VB
cord-326257-rcv8sh22	100	9	retrotransposition	retrotransposition	NN
cord-326257-rcv8sh22	100	10	of	of	IN
cord-326257-rcv8sh22	100	11	a	a	DT
cord-326257-rcv8sh22	100	12	LINE-1	LINE-1	NNP
cord-326257-rcv8sh22	100	13	transposons	transposon	NNS
cord-326257-rcv8sh22	100	14	mRNA	mRNA	VBG
cord-326257-rcv8sh22	100	15	through	through	IN
cord-326257-rcv8sh22	100	16	a	a	DT
cord-326257-rcv8sh22	100	17	non	non	JJ
cord-326257-rcv8sh22	100	18	-	-	JJ
cord-326257-rcv8sh22	100	19	deamination	deamination	JJ
cord-326257-rcv8sh22	100	20	pathway	pathway	NN
cord-326257-rcv8sh22	100	21	(	(	-LRB-
cord-326257-rcv8sh22	100	22	23	23	CD
cord-326257-rcv8sh22	100	23	)	)	-RRB-
cord-326257-rcv8sh22	100	24	,	,	,
cord-326257-rcv8sh22	100	25	potentially	potentially	RB
cord-326257-rcv8sh22	100	26	through	through	IN
cord-326257-rcv8sh22	100	27	binding	bind	VBG
cord-326257-rcv8sh22	100	28	to	to	IN
cord-326257-rcv8sh22	100	29	single	single	RB
cord-326257-rcv8sh22	100	30	-	-	HYPH
cord-326257-rcv8sh22	100	31	stranded	strand	VBN
cord-326257-rcv8sh22	100	32	RNA	RNA	NNP
cord-326257-rcv8sh22	100	33	.	.	.
cord-326257-rcv8sh22	101	1	Direct	direct	JJ
cord-326257-rcv8sh22	101	2	editing	editing	NN
cord-326257-rcv8sh22	101	3	of	of	IN
cord-326257-rcv8sh22	101	4	HIV-1	HIV-1	NNP
cord-326257-rcv8sh22	101	5	RNA	RNA	NNP
cord-326257-rcv8sh22	101	6	by	by	IN
cord-326257-rcv8sh22	101	7	the	the	DT
cord-326257-rcv8sh22	101	8	rat	rat	NN
cord-326257-rcv8sh22	101	9	A1	A1	NNP
cord-326257-rcv8sh22	101	10	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	101	11	and	and	CC
cord-326257-rcv8sh22	101	12	the	the	DT
cord-326257-rcv8sh22	101	13	accumulation	accumulation	NN
cord-326257-rcv8sh22	101	14	of	of	IN
cord-326257-rcv8sh22	101	15	C->U	C->U	NNP
cord-326257-rcv8sh22	101	16	hypermutation	hypermutation	NN
cord-326257-rcv8sh22	101	17	verified	verify	VBD
cord-326257-rcv8sh22	101	18	that	that	IN
cord-326257-rcv8sh22	101	19	210	210	CD
cord-326257-rcv8sh22	101	20	RNA	RNA	NNP
cord-326257-rcv8sh22	101	21	could	could	MD
cord-326257-rcv8sh22	101	22	also	also	RB
cord-326257-rcv8sh22	101	23	be	be	VB
cord-326257-rcv8sh22	101	24	used	use	VBN
cord-326257-rcv8sh22	101	25	as	as	IN
cord-326257-rcv8sh22	101	26	a	a	DT
cord-326257-rcv8sh22	101	27	substrate	substrate	NN
cord-326257-rcv8sh22	101	28	for	for	IN
cord-326257-rcv8sh22	101	29	deamination	deamination	NN
cord-326257-rcv8sh22	101	30	(	(	-LRB-
cord-326257-rcv8sh22	101	31	24	24	CD
cord-326257-rcv8sh22	101	32	)	)	-RRB-
cord-326257-rcv8sh22	101	33	.	.	.
cord-326257-rcv8sh22	102	1	This	this	DT
cord-326257-rcv8sh22	102	2	suggested	suggest	VBD
cord-326257-rcv8sh22	102	3	to	to	IN
cord-326257-rcv8sh22	102	4	the	the	DT
cord-326257-rcv8sh22	102	5	authors	author	NNS
cord-326257-rcv8sh22	102	6	at	at	IN
cord-326257-rcv8sh22	102	7	that	that	DT
cord-326257-rcv8sh22	102	8	time	time	NN
cord-326257-rcv8sh22	102	9	that	that	IN
cord-326257-rcv8sh22	102	10	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	102	11	-	-	HYPH
cord-326257-rcv8sh22	102	12	mediated	mediate	VBN
cord-326257-rcv8sh22	102	13	RNA	RNA	NNP
cord-326257-rcv8sh22	102	14	editing	editing	NN
cord-326257-rcv8sh22	102	15	was	be	VBD
cord-326257-rcv8sh22	102	16	a	a	DT
cord-326257-rcv8sh22	102	17	potential	potential	JJ
cord-326257-rcv8sh22	102	18	antiviral	antiviral	JJ
cord-326257-rcv8sh22	102	19	activity	activity	NN
cord-326257-rcv8sh22	102	20	mechanism	mechanism	NN
cord-326257-rcv8sh22	102	21	against	against	IN
cord-326257-rcv8sh22	102	22	RNA	RNA	NNP
cord-326257-rcv8sh22	102	23	viruses	virus	NNS
cord-326257-rcv8sh22	102	24	as	as	RB
cord-326257-rcv8sh22	102	25	well	well	RB
cord-326257-rcv8sh22	102	26	as	as	IN
cord-326257-rcv8sh22	102	27	retroviruses	retrovirus	NNS
cord-326257-rcv8sh22	102	28	.	.	.
cord-326257-rcv8sh22	103	1	Since	since	IN
cord-326257-rcv8sh22	103	2	then	then	RB
cord-326257-rcv8sh22	103	3	,	,	,
cord-326257-rcv8sh22	103	4	evidence	evidence	NN
cord-326257-rcv8sh22	103	5	supporting	support	VBG
cord-326257-rcv8sh22	103	6	this	this	DT
cord-326257-rcv8sh22	103	7	conjecture	conjecture	NN
cord-326257-rcv8sh22	103	8	has	have	VBZ
cord-326257-rcv8sh22	103	9	been	be	VBN
cord-326257-rcv8sh22	103	10	difficult	difficult	JJ
cord-326257-rcv8sh22	103	11	to	to	TO
cord-326257-rcv8sh22	103	12	obtain	obtain	VB
cord-326257-rcv8sh22	103	13	;	;	:
cord-326257-rcv8sh22	103	14	the	the	DT
cord-326257-rcv8sh22	103	15	virus	virus	NN
cord-326257-rcv8sh22	103	16	inhibitory	inhibitory	JJ
cord-326257-rcv8sh22	103	17	effect	effect	NN
cord-326257-rcv8sh22	103	18	215	215	CD
cord-326257-rcv8sh22	103	19	of	of	IN
cord-326257-rcv8sh22	103	20	APOBECs	apobec	NNS
cord-326257-rcv8sh22	103	21	against	against	IN
cord-326257-rcv8sh22	103	22	enterovirus	enterovirus	NN
cord-326257-rcv8sh22	103	23	A71	A71	NNP
cord-326257-rcv8sh22	103	24	,	,	,
cord-326257-rcv8sh22	103	25	measles	measle	NNS
cord-326257-rcv8sh22	103	26	,	,	,
cord-326257-rcv8sh22	103	27	mumps	mumps	NN
cord-326257-rcv8sh22	103	28	and	and	CC
cord-326257-rcv8sh22	103	29	respiratory	respiratory	JJ
cord-326257-rcv8sh22	103	30	syncytial	syncytial	JJ
cord-326257-rcv8sh22	103	31	viruses	virus	NNS
cord-326257-rcv8sh22	103	32	were	be	VBD
cord-326257-rcv8sh22	103	33	not	not	RB
cord-326257-rcv8sh22	103	34	shown	show	VBN
cord-326257-rcv8sh22	103	35	to	to	TO
cord-326257-rcv8sh22	103	36	be	be	VB
cord-326257-rcv8sh22	103	37	associated	associate	VBN
cord-326257-rcv8sh22	103	38	with	with	IN
cord-326257-rcv8sh22	103	39	the	the	DT
cord-326257-rcv8sh22	103	40	development	development	NN
cord-326257-rcv8sh22	103	41	of	of	IN
cord-326257-rcv8sh22	103	42	virus	virus	NN
cord-326257-rcv8sh22	103	43	mutations	mutation	NNS
cord-326257-rcv8sh22	103	44	(	(	-LRB-
cord-326257-rcv8sh22	103	45	25	25	CD
cord-326257-rcv8sh22	103	46	,	,	,
cord-326257-rcv8sh22	103	47	26	26	CD
cord-326257-rcv8sh22	103	48	)	)	-RRB-
cord-326257-rcv8sh22	103	49	.	.	.
cord-326257-rcv8sh22	104	1	Similarly	similarly	RB
cord-326257-rcv8sh22	104	2	,	,	,
cord-326257-rcv8sh22	104	3	A3C	a3c	CD
cord-326257-rcv8sh22	104	4	,	,	,
cord-326257-rcv8sh22	104	5	A3F	a3f	NN
cord-326257-rcv8sh22	104	6	or	or	CC
cord-326257-rcv8sh22	104	7	A3H	a3h	NN
cord-326257-rcv8sh22	104	8	,	,	,
cord-326257-rcv8sh22	104	9	but	but	CC
cord-326257-rcv8sh22	104	10	not	not	RB
cord-326257-rcv8sh22	104	11	A3A	a3a	CD
cord-326257-rcv8sh22	104	12	,	,	,
cord-326257-rcv8sh22	104	13	A3D	A3D	NNP
cord-326257-rcv8sh22	104	14	and	and	CC
cord-326257-rcv8sh22	104	15	A3	A3	NNP
cord-326257-rcv8sh22	104	16	G	G	NNP
cord-326257-rcv8sh22	104	17	were	be	VBD
cord-326257-rcv8sh22	104	18	shown	show	VBN
cord-326257-rcv8sh22	104	19	to	to	TO
cord-326257-rcv8sh22	104	20	inhibit	inhibit	VB
cord-326257-rcv8sh22	104	21	the	the	DT
cord-326257-rcv8sh22	104	22	replication	replication	NN
cord-326257-rcv8sh22	104	23	of	of	IN
cord-326257-rcv8sh22	104	24	the	the	DT
cord-326257-rcv8sh22	104	25	human	human	JJ
cord-326257-rcv8sh22	104	26	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	104	27	,	,	,
cord-326257-rcv8sh22	104	28	HCoV	HCoV	NNP
cord-326257-rcv8sh22	104	29	-	-	HYPH
cord-326257-rcv8sh22	104	30	NL63	NL63	NNP
cord-326257-rcv8sh22	104	31	,	,	,
cord-326257-rcv8sh22	104	32	but	but	CC
cord-326257-rcv8sh22	104	33	their	-PRON-	PRP$
cord-326257-rcv8sh22	104	34	expression	expression	NN
cord-326257-rcv8sh22	104	35	did	do	VBD
cord-326257-rcv8sh22	104	36	not	not	RB
cord-326257-rcv8sh22	104	37	lead	lead	VB
cord-326257-rcv8sh22	104	38	to	to	IN
cord-326257-rcv8sh22	104	39	de	de	NNP
cord-326257-rcv8sh22	104	40	novo	novo	NNP
cord-326257-rcv8sh22	104	41	C->U	C->U	NNP
cord-326257-rcv8sh22	104	42	(	(	-LRB-
cord-326257-rcv8sh22	104	43	or	or	CC
cord-326257-rcv8sh22	104	44	G->A	G->A	NNP
cord-326257-rcv8sh22	104	45	)	)	-RRB-
cord-326257-rcv8sh22	104	46	mutations	mutation	NNS
cord-326257-rcv8sh22	104	47	on	on	IN
cord-326257-rcv8sh22	104	48	virus	virus	NN
cord-326257-rcv8sh22	104	49	passaging	passaging	NN
cord-326257-rcv8sh22	104	50	(	(	-LRB-
cord-326257-rcv8sh22	104	51	27	27	CD
cord-326257-rcv8sh22	104	52	)	)	-RRB-
cord-326257-rcv8sh22	104	53	.	.	.
cord-326257-rcv8sh22	105	1	On	on	IN
cord-326257-rcv8sh22	105	2	the	the	DT
cord-326257-rcv8sh22	105	3	other	other	JJ
cord-326257-rcv8sh22	105	4	hand	hand	NN
cord-326257-rcv8sh22	105	5	,	,	,
cord-326257-rcv8sh22	105	6	It	-PRON-	PRP
cord-326257-rcv8sh22	105	7	has	have	VBZ
cord-326257-rcv8sh22	105	8	been	be	VBN
cord-326257-rcv8sh22	105	9	demonstrated	demonstrate	VBN
cord-326257-rcv8sh22	105	10	that	that	IN
cord-326257-rcv8sh22	105	11	A3A	a3a	CD
cord-326257-rcv8sh22	105	12	and	and	CC
cord-326257-rcv8sh22	105	13	A3	A3	NNP
cord-326257-rcv8sh22	105	14	G	G	NNP
cord-326257-rcv8sh22	105	15	possess	possess	VBP
cord-326257-rcv8sh22	105	16	potent	potent	JJ
cord-326257-rcv8sh22	105	17	RNA	RNA	NNP
cord-326257-rcv8sh22	105	18	editing	editing	NN
cord-326257-rcv8sh22	105	19	capability	capability	NN
cord-326257-rcv8sh22	105	20	220	220	CD
cord-326257-rcv8sh22	105	21	on	on	IN
cord-326257-rcv8sh22	105	22	mRNA	mRNA	NNP
cord-326257-rcv8sh22	105	23	expressed	express	VBN
cord-326257-rcv8sh22	105	24	in	in	IN
cord-326257-rcv8sh22	105	25	hypoxic	hypoxic	JJ
cord-326257-rcv8sh22	105	26	macrophages	macrophage	NNS
cord-326257-rcv8sh22	105	27	(	(	-LRB-
cord-326257-rcv8sh22	105	28	28	28	CD
cord-326257-rcv8sh22	105	29	)	)	-RRB-
cord-326257-rcv8sh22	105	30	,	,	,
cord-326257-rcv8sh22	105	31	natural	natural	JJ
cord-326257-rcv8sh22	105	32	killer	killer	NN
cord-326257-rcv8sh22	105	33	cells	cell	NNS
cord-326257-rcv8sh22	105	34	(	(	-LRB-
cord-326257-rcv8sh22	105	35	29	29	CD
cord-326257-rcv8sh22	105	36	)	)	-RRB-
cord-326257-rcv8sh22	105	37	and	and	CC
cord-326257-rcv8sh22	105	38	transfected	transfecte	VBD
cord-326257-rcv8sh22	105	39	A3Goverexpressing	a3goverexpresse	VBG
cord-326257-rcv8sh22	105	40	HEK	HEK	NNP
cord-326257-rcv8sh22	105	41	293	293	CD
cord-326257-rcv8sh22	105	42	T	T	NNP
cord-326257-rcv8sh22	105	43	cells	cell	NNS
cord-326257-rcv8sh22	105	44	(	(	-LRB-
cord-326257-rcv8sh22	105	45	30	30	CD
cord-326257-rcv8sh22	105	46	)	)	-RRB-
cord-326257-rcv8sh22	105	47	.	.	.
cord-326257-rcv8sh22	106	1	These	these	DT
cord-326257-rcv8sh22	106	2	latter	latter	JJ
cord-326257-rcv8sh22	106	3	findings	finding	NNS
cord-326257-rcv8sh22	106	4	verify	verify	VBP
cord-326257-rcv8sh22	106	5	that	that	IN
cord-326257-rcv8sh22	106	6	APOBECs	apobec	NNS
cord-326257-rcv8sh22	106	7	do	do	VBP
cord-326257-rcv8sh22	106	8	possess	possess	VB
cord-326257-rcv8sh22	106	9	RNA	RNA	NNP
cord-326257-rcv8sh22	106	10	editing	editing	NN
cord-326257-rcv8sh22	106	11	capabilities	capability	NNS
cord-326257-rcv8sh22	106	12	but	but	CC
cord-326257-rcv8sh22	106	13	do	do	VBP
cord-326257-rcv8sh22	106	14	not	not	RB
cord-326257-rcv8sh22	106	15	provide	provide	VB
cord-326257-rcv8sh22	106	16	any	any	DT
cord-326257-rcv8sh22	106	17	mechanistic	mechanistic	JJ
cord-326257-rcv8sh22	106	18	context	context	NN
cord-326257-rcv8sh22	106	19	for	for	IN
cord-326257-rcv8sh22	106	20	the	the	DT
cord-326257-rcv8sh22	106	21	potential	potential	JJ
cord-326257-rcv8sh22	106	22	inhibition	inhibition	NN
cord-326257-rcv8sh22	106	23	of	of	IN
cord-326257-rcv8sh22	106	24	RNA	RNA	NNP
cord-326257-rcv8sh22	106	25	virus	virus	NN
cord-326257-rcv8sh22	106	26	replication	replication	NN
cord-326257-rcv8sh22	106	27	by	by	IN
cord-326257-rcv8sh22	106	28	this	this	DT
cord-326257-rcv8sh22	106	29	mechanism	mechanism	NN
cord-326257-rcv8sh22	106	30	.	.	.
cord-326257-rcv8sh22	107	1	Nevertheless	nevertheless	RB
cord-326257-rcv8sh22	107	2	the	the	DT
cord-326257-rcv8sh22	107	3	pronounced	pronounced	JJ
cord-326257-rcv8sh22	107	4	asymmetry	asymmetry	NN
cord-326257-rcv8sh22	107	5	in	in	IN
cord-326257-rcv8sh22	107	6	C->U	c->u	NN
cord-326257-rcv8sh22	107	7	transitions	transition	NNS
cord-326257-rcv8sh22	107	8	in	in	IN
cord-326257-rcv8sh22	107	9	SARS	SARS	NNP
cord-326257-rcv8sh22	107	10	-	-	HYPH
cord-326257-rcv8sh22	107	11	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	107	12	and	and	CC
cord-326257-rcv8sh22	107	13	the	the	DT
cord-326257-rcv8sh22	107	14	preferential	preferential	JJ
cord-326257-rcv8sh22	107	15	substitution	substitution	NN
cord-326257-rcv8sh22	107	16	of	of	IN
cord-326257-rcv8sh22	107	17	C	C	NNP
cord-326257-rcv8sh22	107	18	's	's	POS
cord-326257-rcv8sh22	107	19	flanked	flank	VBN
cord-326257-rcv8sh22	107	20	by	by	IN
cord-326257-rcv8sh22	107	21	U	U	NNP
cord-326257-rcv8sh22	107	22	and	and	CC
cord-326257-rcv8sh22	107	23	A	a	DT
cord-326257-rcv8sh22	107	24	bases	basis	NNS
cord-326257-rcv8sh22	107	25	on	on	IN
cord-326257-rcv8sh22	107	26	both	both	DT
cord-326257-rcv8sh22	107	27	5	5	CD
cord-326257-rcv8sh22	107	28	'	'	''
cord-326257-rcv8sh22	107	29	and	and	CC
cord-326257-rcv8sh22	107	30	3	3	CD
cord-326257-rcv8sh22	107	31	'	'	POS
cord-326257-rcv8sh22	107	32	sides	side	NNS
cord-326257-rcv8sh22	107	33	(	(	-LRB-
cord-326257-rcv8sh22	107	34	Fig	Fig	NNP
cord-326257-rcv8sh22	107	35	.	.	.
cord-326257-rcv8sh22	107	36	6	6	CD
cord-326257-rcv8sh22	107	37	)	)	-RRB-
cord-326257-rcv8sh22	107	38	225	225	CD
cord-326257-rcv8sh22	107	39	that	that	WDT
cord-326257-rcv8sh22	107	40	broadly	broadly	RB
cord-326257-rcv8sh22	107	41	matches	match	VBZ
cord-326257-rcv8sh22	107	42	what	what	WP
cord-326257-rcv8sh22	107	43	is	be	VBZ
cord-326257-rcv8sh22	107	44	known	know	VBN
cord-326257-rcv8sh22	107	45	about	about	IN
cord-326257-rcv8sh22	107	46	the	the	DT
cord-326257-rcv8sh22	107	47	favoured	favour	VBN
cord-326257-rcv8sh22	107	48	contexts	context	NNS
cord-326257-rcv8sh22	107	49	of	of	IN
cord-326257-rcv8sh22	107	50	A3A	a3a	CD
cord-326257-rcv8sh22	107	51	,	,	,
cord-326257-rcv8sh22	107	52	A3F	a3f	NN
cord-326257-rcv8sh22	107	53	and	and	CC
cord-326257-rcv8sh22	107	54	A3H	a3h	NN
cord-326257-rcv8sh22	107	55	(	(	-LRB-
cord-326257-rcv8sh22	107	56	31	31	CD
cord-326257-rcv8sh22	107	57	)	)	-RRB-
cord-326257-rcv8sh22	107	58	provides	provide	VBZ
cord-326257-rcv8sh22	107	59	strong	strong	JJ
cord-326257-rcv8sh22	107	60	circumstantial	circumstantial	JJ
cord-326257-rcv8sh22	107	61	grounds	ground	NNS
cord-326257-rcv8sh22	107	62	for	for	IN
cord-326257-rcv8sh22	107	63	suspecting	suspect	VBG
cord-326257-rcv8sh22	107	64	a	a	DT
cord-326257-rcv8sh22	107	65	role	role	NN
cord-326257-rcv8sh22	107	66	of	of	IN
cord-326257-rcv8sh22	107	67	one	one	CD
cord-326257-rcv8sh22	107	68	or	or	CC
cord-326257-rcv8sh22	107	69	more	more	JJR
cord-326257-rcv8sh22	107	70	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	107	71	proteins	protein	NNS
cord-326257-rcv8sh22	107	72	in	in	IN
cord-326257-rcv8sh22	107	73	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	107	74	mutagenesis	mutagenesis	NN
cord-326257-rcv8sh22	107	75	.	.	.
cord-326257-rcv8sh22	108	1	Their	-PRON-	PRP$
cord-326257-rcv8sh22	108	2	exceptionally	exceptionally	RB
cord-326257-rcv8sh22	108	3	long	long	JJ
cord-326257-rcv8sh22	108	4	genomes	genome	NNS
cord-326257-rcv8sh22	108	5	(	(	-LRB-
cord-326257-rcv8sh22	108	6	≈30,000	≈30,000	NN
cord-326257-rcv8sh22	108	7	bases	basis	NNS
cord-326257-rcv8sh22	108	8	)	)	-RRB-
cord-326257-rcv8sh22	108	9	,	,	,
cord-326257-rcv8sh22	108	10	the	the	DT
cord-326257-rcv8sh22	108	11	exposure	exposure	NN
cord-326257-rcv8sh22	108	12	of	of	IN
cord-326257-rcv8sh22	108	13	genomic	genomic	JJ
cord-326257-rcv8sh22	108	14	RNA	RNA	NNP
cord-326257-rcv8sh22	108	15	in	in	IN
cord-326257-rcv8sh22	108	16	the	the	DT
cord-326257-rcv8sh22	108	17	cytoplasm	cytoplasm	NN
cord-326257-rcv8sh22	108	18	before	before	IN
cord-326257-rcv8sh22	108	19	initiation	initiation	NN
cord-326257-rcv8sh22	108	20	of	of	IN
cord-326257-rcv8sh22	108	21	replication	replication	NN
cord-326257-rcv8sh22	108	22	complex	complex	JJ
cord-326257-rcv8sh22	108	23	formation	formation	NN
cord-326257-rcv8sh22	108	24	and	and	CC
cord-326257-rcv8sh22	108	25	the	the	DT
cord-326257-rcv8sh22	108	26	potentially	potentially	RB
cord-326257-rcv8sh22	108	27	lethal	lethal	JJ
cord-326257-rcv8sh22	108	28	effects	effect	NNS
cord-326257-rcv8sh22	108	29	of	of	IN
cord-326257-rcv8sh22	108	30	just	just	RB
cord-326257-rcv8sh22	108	31	one	one	CD
cord-326257-rcv8sh22	108	32	mutations	mutation	NNS
cord-326257-rcv8sh22	108	33	introduced	introduce	VBN
cord-326257-rcv8sh22	108	34	into	into	IN
cord-326257-rcv8sh22	108	35	the	the	DT
cord-326257-rcv8sh22	108	36	genomic	genomic	JJ
cord-326257-rcv8sh22	108	37	sequence	sequence	NN
cord-326257-rcv8sh22	108	38	makes	make	VBZ
cord-326257-rcv8sh22	108	39	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	108	40	-	-	HYPH
cord-326257-rcv8sh22	108	41	mediated	mediate	VBN
cord-326257-rcv8sh22	108	42	anti	anti	JJ
cord-326257-rcv8sh22	108	43	-	-	JJ
cord-326257-rcv8sh22	108	44	coronaviral	coronaviral	JJ
cord-326257-rcv8sh22	108	45	230	230	CD
cord-326257-rcv8sh22	108	46	activity	activity	NN
cord-326257-rcv8sh22	108	47	plausible	plausible	JJ
cord-326257-rcv8sh22	108	48	in	in	IN
cord-326257-rcv8sh22	108	49	virological	virological	JJ
cord-326257-rcv8sh22	108	50	terms	term	NNS
cord-326257-rcv8sh22	108	51	.	.	.
cord-326257-rcv8sh22	109	1	It	-PRON-	PRP
cord-326257-rcv8sh22	109	2	is	be	VBZ
cord-326257-rcv8sh22	109	3	perhaps	perhaps	RB
cord-326257-rcv8sh22	109	4	because	because	IN
cord-326257-rcv8sh22	109	5	of	of	IN
cord-326257-rcv8sh22	109	6	the	the	DT
cord-326257-rcv8sh22	109	7	otherwise	otherwise	RB
cord-326257-rcv8sh22	109	8	low	low	JJ
cord-326257-rcv8sh22	109	9	mutation	mutation	NN
cord-326257-rcv8sh22	109	10	rate	rate	NN
cord-326257-rcv8sh22	109	11	of	of	IN
cord-326257-rcv8sh22	109	12	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	109	13	and	and	CC
cord-326257-rcv8sh22	109	14	the	the	DT
cord-326257-rcv8sh22	109	15	extensive	extensive	JJ
cord-326257-rcv8sh22	109	16	dataset	dataset	NN
cord-326257-rcv8sh22	109	17	of	of	IN
cord-326257-rcv8sh22	109	18	accurate	accurate	JJ
cord-326257-rcv8sh22	109	19	,	,	,
cord-326257-rcv8sh22	109	20	minimally	minimally	RB
cord-326257-rcv8sh22	109	21	divergent	divergent	JJ
cord-326257-rcv8sh22	109	22	SARS	SARS	NNP
cord-326257-rcv8sh22	109	23	-	-	HYPH
cord-326257-rcv8sh22	109	24	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	109	25	sequences	sequence	NNS
cord-326257-rcv8sh22	109	26	assembled	assemble	VBD
cord-326257-rcv8sh22	109	27	post	post	NN
cord-326257-rcv8sh22	109	28	-	-	JJ
cord-326257-rcv8sh22	109	29	pandemic	pandemic	JJ
cord-326257-rcv8sh22	109	30	that	that	WDT
cord-326257-rcv8sh22	109	31	has	have	VBZ
cord-326257-rcv8sh22	109	32	enabled	enable	VBN
cord-326257-rcv8sh22	109	33	this	this	DT
cord-326257-rcv8sh22	109	34	mutational	mutational	JJ
cord-326257-rcv8sh22	109	35	signature	signature	NN
cord-326257-rcv8sh22	109	36	to	to	TO
cord-326257-rcv8sh22	109	37	be	be	VB
cord-326257-rcv8sh22	109	38	so	so	RB
cord-326257-rcv8sh22	109	39	clearly	clearly	RB
cord-326257-rcv8sh22	109	40	observed	observe	VBN
cord-326257-rcv8sh22	109	41	.	.	.
cord-326257-rcv8sh22	110	1	The	the	DT
cord-326257-rcv8sh22	110	2	key	key	JJ
cord-326257-rcv8sh22	110	3	finding	finding	NN
cord-326257-rcv8sh22	110	4	in	in	IN
cord-326257-rcv8sh22	110	5	the	the	DT
cord-326257-rcv8sh22	110	6	study	study	NN
cord-326257-rcv8sh22	110	7	was	be	VBD
cord-326257-rcv8sh22	110	8	the	the	DT
cord-326257-rcv8sh22	110	9	combined	combine	VBN
cord-326257-rcv8sh22	110	10	evidence	evidence	NN
cord-326257-rcv8sh22	110	11	for	for	IN
cord-326257-rcv8sh22	110	12	an	an	DT
cord-326257-rcv8sh22	110	13	APOBEC-235	APOBEC-235	NNP
cord-326257-rcv8sh22	110	14	like	like	IN
cord-326257-rcv8sh22	110	15	editing	editing	NN
cord-326257-rcv8sh22	110	16	process	process	NN
cord-326257-rcv8sh22	110	17	driving	drive	VBG
cord-326257-rcv8sh22	110	18	initial	initial	JJ
cord-326257-rcv8sh22	110	19	sequences	sequence	NNS
cord-326257-rcv8sh22	110	20	changes	change	NNS
cord-326257-rcv8sh22	110	21	in	in	IN
cord-326257-rcv8sh22	110	22	SARS	SARS	NNP
cord-326257-rcv8sh22	110	23	-	-	HYPH
cord-326257-rcv8sh22	110	24	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	110	25	and	and	CC
cord-326257-rcv8sh22	110	26	that	that	IN
cord-326257-rcv8sh22	110	27	the	the	DT
cord-326257-rcv8sh22	110	28	observed	observed	JJ
cord-326257-rcv8sh22	110	29	substitutions	substitution	NNS
cord-326257-rcv8sh22	110	30	have	have	VBP
cord-326257-rcv8sh22	110	31	not	not	RB
cord-326257-rcv8sh22	110	32	arisen	arise	VBN
cord-326257-rcv8sh22	110	33	through	through	IN
cord-326257-rcv8sh22	110	34	a	a	DT
cord-326257-rcv8sh22	110	35	typical	typical	JJ
cord-326257-rcv8sh22	110	36	pattern	pattern	NN
cord-326257-rcv8sh22	110	37	on	on	IN
cord-326257-rcv8sh22	110	38	random	random	JJ
cord-326257-rcv8sh22	110	39	mutation	mutation	NN
cord-326257-rcv8sh22	110	40	and	and	CC
cord-326257-rcv8sh22	110	41	fixation	fixation	NN
cord-326257-rcv8sh22	110	42	that	that	WDT
cord-326257-rcv8sh22	110	43	is	be	VBZ
cord-326257-rcv8sh22	110	44	assumed	assume	VBN
cord-326257-rcv8sh22	110	45	in	in	IN
cord-326257-rcv8sh22	110	46	evolutionary	evolutionary	JJ
cord-326257-rcv8sh22	110	47	models	model	NNS
cord-326257-rcv8sh22	110	48	.	.	.
cord-326257-rcv8sh22	111	1	A	a	DT
cord-326257-rcv8sh22	111	2	specific	specific	JJ
cord-326257-rcv8sh22	111	3	problem	problem	NN
cord-326257-rcv8sh22	111	4	for	for	IN
cord-326257-rcv8sh22	111	5	evolutionary	evolutionary	JJ
cord-326257-rcv8sh22	111	6	reconstructions	reconstruction	NNS
cord-326257-rcv8sh22	111	7	would	would	MD
cord-326257-rcv8sh22	111	8	be	be	VB
cord-326257-rcv8sh22	111	9	the	the	DT
cord-326257-rcv8sh22	111	10	existence	existence	NN
cord-326257-rcv8sh22	111	11	of	of	IN
cord-326257-rcv8sh22	111	12	highly	highly	RB
cord-326257-rcv8sh22	111	13	uneven	uneven	JJ
cord-326257-rcv8sh22	111	14	substitution	substitution	NN
cord-326257-rcv8sh22	111	15	rates	rate	NNS
cord-326257-rcv8sh22	111	16	at	at	IN
cord-326257-rcv8sh22	111	17	different	different	JJ
cord-326257-rcv8sh22	111	18	sites	site	NNS
cord-326257-rcv8sh22	111	19	;	;	:
cord-326257-rcv8sh22	111	20	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	111	21	-	-	HYPH
cord-326257-rcv8sh22	111	22	mediated	mediate	VBN
cord-326257-rcv8sh22	111	23	editing	editing	NN
cord-326257-rcv8sh22	111	24	(	(	-LRB-
cord-326257-rcv8sh22	111	25	and	and	CC
cord-326257-rcv8sh22	111	26	indeed	indeed	RB
cord-326257-rcv8sh22	111	27	the	the	DT
cord-326257-rcv8sh22	111	28	pattern	pattern	NN
cord-326257-rcv8sh22	111	29	of	of	IN
cord-326257-rcv8sh22	111	30	C	c	NN
cord-326257-rcv8sh22	111	31	-	-	HYPH
cord-326257-rcv8sh22	111	32	U	U	NNP
cord-326257-rcv8sh22	111	33	transition	transition	NN
cord-326257-rcv8sh22	111	34	in	in	IN
cord-326257-rcv8sh22	111	35	SARS	SARS	NNP
cord-326257-rcv8sh22	111	36	-	-	HYPH
cord-326257-rcv8sh22	111	37	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	111	38	sequences	sequence	NNS
cord-326257-rcv8sh22	111	39	)	)	-RRB-
cord-326257-rcv8sh22	111	40	is	be	VBZ
cord-326257-rcv8sh22	111	41	strongly	strongly	RB
cord-326257-rcv8sh22	111	42	dependent	dependent	JJ
cord-326257-rcv8sh22	111	43	on	on	IN
cord-326257-rcv8sh22	111	44	sequence	sequence	NN
cord-326257-rcv8sh22	111	45	context	context	NN
cord-326257-rcv8sh22	111	46	240	240	CD
cord-326257-rcv8sh22	111	47	and	and	CC
cord-326257-rcv8sh22	111	48	,	,	,
cord-326257-rcv8sh22	111	49	for	for	IN
cord-326257-rcv8sh22	111	50	at	at	RB
cord-326257-rcv8sh22	111	51	least	least	RBS
cord-326257-rcv8sh22	111	52	two	two	CD
cord-326257-rcv8sh22	111	53	APOBECs	apobec	NNS
cord-326257-rcv8sh22	111	54	,	,	,
cord-326257-rcv8sh22	111	55	additionally	additionally	RB
cord-326257-rcv8sh22	111	56	influenced	influence	VBN
cord-326257-rcv8sh22	111	57	by	by	IN
cord-326257-rcv8sh22	111	58	their	-PRON-	PRP$
cord-326257-rcv8sh22	111	59	proximity	proximity	NN
cord-326257-rcv8sh22	111	60	to	to	IN
cord-326257-rcv8sh22	111	61	RNA	RNA	NNP
cord-326257-rcv8sh22	111	62	secondary	secondary	JJ
cord-326257-rcv8sh22	111	63	structure	structure	NN
cord-326257-rcv8sh22	111	64	elements	element	NNS
cord-326257-rcv8sh22	111	65	in	in	IN
cord-326257-rcv8sh22	111	66	the	the	DT
cord-326257-rcv8sh22	111	67	target	target	NN
cord-326257-rcv8sh22	111	68	sequence	sequence	NN
cord-326257-rcv8sh22	111	69	(	(	-LRB-
cord-326257-rcv8sh22	111	70	28	28	CD
cord-326257-rcv8sh22	111	71	,	,	,
cord-326257-rcv8sh22	111	72	31	31	CD
cord-326257-rcv8sh22	111	73	)	)	-RRB-
cord-326257-rcv8sh22	111	74	.	.	.
cord-326257-rcv8sh22	112	1	Sequence	sequence	NN
cord-326257-rcv8sh22	112	2	changes	change	NNS
cord-326257-rcv8sh22	112	3	in	in	IN
cord-326257-rcv8sh22	112	4	SARS	SARS	NNP
cord-326257-rcv8sh22	112	5	-	-	HYPH
cord-326257-rcv8sh22	112	6	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	112	7	and	and	CC
cord-326257-rcv8sh22	112	8	other	other	JJ
cord-326257-rcv8sh22	112	9	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	112	10	genomes	genome	NNS
cord-326257-rcv8sh22	112	11	may	may	MD
cord-326257-rcv8sh22	112	12	therefore	therefore	RB
cord-326257-rcv8sh22	112	13	be	be	VB
cord-326257-rcv8sh22	112	14	partially	partially	RB
cord-326257-rcv8sh22	112	15	or	or	CC
cord-326257-rcv8sh22	112	16	largely	largely	RB
cord-326257-rcv8sh22	112	17	restricted	restricted	JJ
cord-326257-rcv8sh22	112	18	to	to	IN
cord-326257-rcv8sh22	112	19	number	number	NN
cord-326257-rcv8sh22	112	20	of	of	IN
cord-326257-rcv8sh22	112	21	mutational	mutational	JJ
cord-326257-rcv8sh22	112	22	hotspots	hotspot	NNS
cord-326257-rcv8sh22	112	23	that	that	WDT
cord-326257-rcv8sh22	112	24	may	may	MD
cord-326257-rcv8sh22	112	25	promote	promote	VB
cord-326257-rcv8sh22	112	26	convergent	convergent	JJ
cord-326257-rcv8sh22	112	27	changes	change	NNS
cord-326257-rcv8sh22	112	28	between	between	IN
cord-326257-rcv8sh22	112	29	otherwise	otherwise	RB
cord-326257-rcv8sh22	112	30	genetically	genetically	RB
cord-326257-rcv8sh22	112	31	unlinked	unlinked	JJ
cord-326257-rcv8sh22	112	32	strains	strain	NNS
cord-326257-rcv8sh22	112	33	.	.	.
cord-326257-rcv8sh22	113	1	As	as	IN
cord-326257-rcv8sh22	113	2	demonstrated	demonstrate	VBN
cord-326257-rcv8sh22	113	3	in	in	IN
cord-326257-rcv8sh22	113	4	Fig	Fig	NNP
cord-326257-rcv8sh22	113	5	.	.	.
cord-326257-rcv8sh22	113	6	  	  	_SP
cord-326257-rcv8sh22	114	1	4	4	LS
cord-326257-rcv8sh22	114	2	,	,	,
cord-326257-rcv8sh22	114	3	these	these	DT
cord-326257-rcv8sh22	114	4	can	can	MD
cord-326257-rcv8sh22	114	5	conflict	conflict	VB
cord-326257-rcv8sh22	114	6	with	with	IN
cord-326257-rcv8sh22	114	7	relationships	relationship	NNS
cord-326257-rcv8sh22	114	8	reconstructed	reconstruct	VBN
cord-326257-rcv8sh22	114	9	from	from	IN
cord-326257-rcv8sh22	114	10	phylogenetically	phylogenetically	RB
cord-326257-rcv8sh22	114	11	informative	informative	JJ
cord-326257-rcv8sh22	114	12	sites	site	NNS
cord-326257-rcv8sh22	114	13	.	.	.
cord-326257-rcv8sh22	114	14	 	 	_SP
cord-326257-rcv8sh22	115	1	The	the	DT
cord-326257-rcv8sh22	115	2	other	other	JJ
cord-326257-rcv8sh22	115	3	important	important	JJ
cord-326257-rcv8sh22	115	4	consequence	consequence	NN
cord-326257-rcv8sh22	115	5	of	of	IN
cord-326257-rcv8sh22	115	6	C->U	c->u	NN
cord-326257-rcv8sh22	115	7	hypermutation	hypermutation	NN
cord-326257-rcv8sh22	115	8	is	be	VBZ
cord-326257-rcv8sh22	115	9	that	that	IN
cord-326257-rcv8sh22	115	10	most	most	JJS
cord-326257-rcv8sh22	115	11	of	of	IN
cord-326257-rcv8sh22	115	12	the	the	DT
cord-326257-rcv8sh22	115	13	amino	amino	NN
cord-326257-rcv8sh22	115	14	acid	acid	NN
cord-326257-rcv8sh22	115	15	sequence	sequence	NN
cord-326257-rcv8sh22	115	16	diversity	diversity	NN
cord-326257-rcv8sh22	115	17	observed	observe	VBN
cord-326257-rcv8sh22	115	18	in	in	IN
cord-326257-rcv8sh22	115	19	SARS	SARS	NNP
cord-326257-rcv8sh22	115	20	-	-	HYPH
cord-326257-rcv8sh22	115	21	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	115	22	strains	strain	NNS
cord-326257-rcv8sh22	115	23	originates	originate	VBZ
cord-326257-rcv8sh22	115	24	directly	directly	RB
cord-326257-rcv8sh22	115	25	from	from	IN
cord-326257-rcv8sh22	115	26	forced	force	VBN
cord-326257-rcv8sh22	115	27	mutations	mutation	NNS
cord-326257-rcv8sh22	115	28	and	and	CC
cord-326257-rcv8sh22	115	29	therefore	therefore	RB
cord-326257-rcv8sh22	115	30	can	can	MD
cord-326257-rcv8sh22	115	31	not	not	RB
cord-326257-rcv8sh22	115	32	be	be	VB
cord-326257-rcv8sh22	115	33	regarded	regard	VBN
cord-326257-rcv8sh22	115	34	in	in	IN
cord-326257-rcv8sh22	115	35	any	any	DT
cord-326257-rcv8sh22	115	36	way	way	NN
cord-326257-rcv8sh22	115	37	as	as	IN
cord-326257-rcv8sh22	115	38	adaptive	adaptive	JJ
cord-326257-rcv8sh22	115	39	for	for	IN
cord-326257-rcv8sh22	115	40	the	the	DT
cord-326257-rcv8sh22	115	41	virus	virus	NN
cord-326257-rcv8sh22	116	1	(	(	-LRB-
cord-326257-rcv8sh22	116	2	Fig	Fig	NNP
cord-326257-rcv8sh22	116	3	.	.	NNP
cord-326257-rcv8sh22	116	4	5	5	CD
cord-326257-rcv8sh22	116	5	)	)	-RRB-
cord-326257-rcv8sh22	116	6	.	.	.
cord-326257-rcv8sh22	117	1	An	an	DT
cord-326257-rcv8sh22	117	2	RNA	RNA	NNP
cord-326257-rcv8sh22	117	3	editing	editing	NN
cord-326257-rcv8sh22	117	4	mechanism	mechanism	NN
cord-326257-rcv8sh22	117	5	of	of	IN
cord-326257-rcv8sh22	117	6	the	the	DT
cord-326257-rcv8sh22	117	7	type	type	NN
cord-326257-rcv8sh22	117	8	discussed	discuss	VBN
cord-326257-rcv8sh22	117	9	above	above	IN
cord-326257-rcv8sh22	117	10	evidently	evidently	RB
cord-326257-rcv8sh22	117	11	places	place	VBZ
cord-326257-rcv8sh22	117	12	a	a	DT
cord-326257-rcv8sh22	117	13	huge	huge	JJ
cord-326257-rcv8sh22	117	14	mutational	mutational	JJ
cord-326257-rcv8sh22	117	15	load	load	NN
cord-326257-rcv8sh22	117	16	on	on	IN
cord-326257-rcv8sh22	117	17	SARS	SARS	NNP
cord-326257-rcv8sh22	117	18	-	-	HYPH
cord-326257-rcv8sh22	117	19	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	117	20	that	that	WDT
cord-326257-rcv8sh22	117	21	may	may	MD
cord-326257-rcv8sh22	117	22	underpin	underpin	VB
cord-326257-rcv8sh22	117	23	the	the	DT
cord-326257-rcv8sh22	117	24	abnormally	abnormally	RB
cord-326257-rcv8sh22	117	25	high	high	JJ
cord-326257-rcv8sh22	117	26	dN/	dn/	NN
cord-326257-rcv8sh22	118	1	dS	dS	NNP
cord-326257-rcv8sh22	118	2	ratios	ratio	NNS
cord-326257-rcv8sh22	118	3	recorded	record	VBN
cord-326257-rcv8sh22	118	4	in	in	IN
cord-326257-rcv8sh22	118	5	SARS	SARS	NNP
cord-326257-rcv8sh22	118	6	-	-	HYPH
cord-326257-rcv8sh22	118	7	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	118	8	and	and	CC
cord-326257-rcv8sh22	118	9	SARS	SARS	NNP
cord-326257-rcv8sh22	118	10	-	-	HYPH
cord-326257-rcv8sh22	118	11	CoV	CoV	NNP
cord-326257-rcv8sh22	118	12	sequence	sequence	NN
cord-326257-rcv8sh22	118	13	datasets	dataset	NNS
cord-326257-rcv8sh22	118	14	(	(	-LRB-
cord-326257-rcv8sh22	118	15	Fig	Fig	NNP
cord-326257-rcv8sh22	118	16	.	.	.
cord-326257-rcv8sh22	118	17	1	1	CD
cord-326257-rcv8sh22	118	18	)	)	-RRB-
cord-326257-rcv8sh22	118	19	.	.	.
cord-326257-rcv8sh22	119	1	It	-PRON-	PRP
cord-326257-rcv8sh22	119	2	is	be	VBZ
cord-326257-rcv8sh22	119	3	260	260	CD
cord-326257-rcv8sh22	119	4	likely	likely	RB
cord-326257-rcv8sh22	119	5	that	that	IN
cord-326257-rcv8sh22	119	6	many	many	JJ
cord-326257-rcv8sh22	119	7	or	or	CC
cord-326257-rcv8sh22	119	8	most	most	JJS
cord-326257-rcv8sh22	119	9	amino	amino	NN
cord-326257-rcv8sh22	119	10	acid	acid	NN
cord-326257-rcv8sh22	119	11	changes	change	NNS
cord-326257-rcv8sh22	119	12	are	be	VBP
cord-326257-rcv8sh22	119	13	mildly	mildly	RB
cord-326257-rcv8sh22	119	14	deleterious	deleterious	JJ
cord-326257-rcv8sh22	119	15	and	and	CC
cord-326257-rcv8sh22	119	16	transient	transient	JJ
cord-326257-rcv8sh22	119	17	;	;	:
cord-326257-rcv8sh22	119	18	repeated	repeat	VBN
cord-326257-rcv8sh22	119	19	rounds	round	NNS
cord-326257-rcv8sh22	119	20	of	of	IN
cord-326257-rcv8sh22	119	21	mutation	mutation	NN
cord-326257-rcv8sh22	119	22	at	at	IN
cord-326257-rcv8sh22	119	23	favoured	favour	VBN
cord-326257-rcv8sh22	119	24	editing	editing	NN
cord-326257-rcv8sh22	119	25	sites	site	NNS
cord-326257-rcv8sh22	119	26	followed	follow	VBN
cord-326257-rcv8sh22	119	27	by	by	IN
cord-326257-rcv8sh22	119	28	reversion	reversion	NN
cord-326257-rcv8sh22	119	29	may	may	MD
cord-326257-rcv8sh22	119	30	therefore	therefore	RB
cord-326257-rcv8sh22	119	31	contribute	contribute	VB
cord-326257-rcv8sh22	119	32	to	to	IN
cord-326257-rcv8sh22	119	33	the	the	DT
cord-326257-rcv8sh22	119	34	large	large	JJ
cord-326257-rcv8sh22	119	35	numbers	number	NNS
cord-326257-rcv8sh22	119	36	of	of	IN
cord-326257-rcv8sh22	119	37	scattered	scatter	VBN
cord-326257-rcv8sh22	119	38	substitutions	substitution	NNS
cord-326257-rcv8sh22	119	39	in	in	IN
cord-326257-rcv8sh22	119	40	SARS	SARS	NNP
cord-326257-rcv8sh22	119	41	-	-	HYPH
cord-326257-rcv8sh22	119	42	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	119	43	sequences	sequence	NNS
cord-326257-rcv8sh22	119	44	that	that	WDT
cord-326257-rcv8sh22	119	45	conflict	conflict	NN
cord-326257-rcv8sh22	119	46	with	with	IN
cord-326257-rcv8sh22	119	47	their	-PRON-	PRP$
cord-326257-rcv8sh22	119	48	phylogeny	phylogeny	NN
cord-326257-rcv8sh22	119	49	.	.	.
cord-326257-rcv8sh22	120	1	Finally	finally	RB
cord-326257-rcv8sh22	120	2	,	,	,
cord-326257-rcv8sh22	120	3	it	-PRON-	PRP
cord-326257-rcv8sh22	120	4	is	be	VBZ
cord-326257-rcv8sh22	120	5	intriguing	intriguing	JJ
cord-326257-rcv8sh22	120	6	to	to	TO
cord-326257-rcv8sh22	120	7	speculate	speculate	VB
cord-326257-rcv8sh22	120	8	on	on	IN
cord-326257-rcv8sh22	120	9	the	the	DT
cord-326257-rcv8sh22	120	10	long	long	JJ
cord-326257-rcv8sh22	120	11	-	-	HYPH
cord-326257-rcv8sh22	120	12	term	term	NN
cord-326257-rcv8sh22	120	13	effects	effect	NNS
cord-326257-rcv8sh22	120	14	of	of	IN
cord-326257-rcv8sh22	120	15	the	the	DT
cord-326257-rcv8sh22	120	16	C->U	C->U	NNP
cord-326257-rcv8sh22	120	17	/	/	SYM
cord-326257-rcv8sh22	120	18	U->C	U->C	NNP
cord-326257-rcv8sh22	120	19	asymmetry	asymmetry	NN
cord-326257-rcv8sh22	120	20	and	and	CC
cord-326257-rcv8sh22	120	21	the	the	DT
cord-326257-rcv8sh22	120	22	265	265	CD
cord-326257-rcv8sh22	120	23	extent	extent	NN
cord-326257-rcv8sh22	120	24	to	to	IN
cord-326257-rcv8sh22	120	25	which	which	WDT
cord-326257-rcv8sh22	120	26	this	this	DT
cord-326257-rcv8sh22	120	27	may	may	MD
cord-326257-rcv8sh22	120	28	contribute	contribute	VB
cord-326257-rcv8sh22	120	29	to	to	IN
cord-326257-rcv8sh22	120	30	the	the	DT
cord-326257-rcv8sh22	120	31	previously	previously	RB
cord-326257-rcv8sh22	120	32	described	describe	VBN
cord-326257-rcv8sh22	120	33	compositional	compositional	JJ
cord-326257-rcv8sh22	120	34	abnormalities	abnormality	NNS
cord-326257-rcv8sh22	120	35	of	of	IN
cord-326257-rcv8sh22	120	36	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	120	37	(	(	-LRB-
cord-326257-rcv8sh22	120	38	32	32	CD
cord-326257-rcv8sh22	120	39	,	,	,
cord-326257-rcv8sh22	120	40	33	33	CD
cord-326257-rcv8sh22	120	41	)	)	-RRB-
cord-326257-rcv8sh22	120	42	.	.	.
cord-326257-rcv8sh22	121	1	As	as	IN
cord-326257-rcv8sh22	121	2	described	describe	VBN
cord-326257-rcv8sh22	121	3	above	above	RB
cord-326257-rcv8sh22	121	4	in	in	IN
cord-326257-rcv8sh22	121	5	connection	connection	NN
cord-326257-rcv8sh22	121	6	with	with	IN
cord-326257-rcv8sh22	121	7	mutation	mutation	NN
cord-326257-rcv8sh22	121	8	frequencies	frequency	NNS
cord-326257-rcv8sh22	121	9	,	,	,
cord-326257-rcv8sh22	121	10	the	the	DT
cord-326257-rcv8sh22	121	11	compositional	compositional	JJ
cord-326257-rcv8sh22	121	12	asymmetries	asymmetry	NNS
cord-326257-rcv8sh22	121	13	can	can	MD
cord-326257-rcv8sh22	121	14	not	not	RB
cord-326257-rcv8sh22	121	15	directly	directly	RB
cord-326257-rcv8sh22	121	16	arise	arise	VB
cord-326257-rcv8sh22	121	17	through	through	IN
cord-326257-rcv8sh22	121	18	viral	viral	JJ
cord-326257-rcv8sh22	121	19	RdRp	RdRp	NNP
cord-326257-rcv8sh22	121	20	mutational	mutational	JJ
cord-326257-rcv8sh22	121	21	biases	bias	NNS
cord-326257-rcv8sh22	121	22	because	because	IN
cord-326257-rcv8sh22	121	23	any	any	DT
cord-326257-rcv8sh22	121	24	resulting	result	VBG
cord-326257-rcv8sh22	121	25	base	base	NN
cord-326257-rcv8sh22	121	26	frequency	frequency	NN
cord-326257-rcv8sh22	121	27	differences	difference	NNS
cord-326257-rcv8sh22	121	28	would	would	MD
cord-326257-rcv8sh22	121	29	be	be	VB
cord-326257-rcv8sh22	121	30	symmetric	symmetric	JJ
cord-326257-rcv8sh22	121	31	(	(	-LRB-
cord-326257-rcv8sh22	121	32	ie	ie	FW
cord-326257-rcv8sh22	121	33	.	.	.
cord-326257-rcv8sh22	122	1	G≈C	G≈C	NNP
cord-326257-rcv8sh22	122	2	,	,	,
cord-326257-rcv8sh22	122	3	A≈U	A≈U	NNP
cord-326257-rcv8sh22	122	4	)	)	-RRB-
cord-326257-rcv8sh22	122	5	.	.	.
cord-326257-rcv8sh22	123	1	Instead	instead	RB
cord-326257-rcv8sh22	123	2	it	-PRON-	PRP
cord-326257-rcv8sh22	123	3	appears	appear	VBZ
cord-326257-rcv8sh22	123	4	that	that	IN
cord-326257-rcv8sh22	123	5	the	the	DT
cord-326257-rcv8sh22	123	6	observed	observed	JJ
cord-326257-rcv8sh22	123	7	imbalances	imbalance	NNS
cord-326257-rcv8sh22	123	8	in	in	IN
cord-326257-rcv8sh22	123	9	frequencies	frequency	NNS
cord-326257-rcv8sh22	123	10	of	of	IN
cord-326257-rcv8sh22	123	11	complementary	complementary	JJ
cord-326257-rcv8sh22	123	12	bases	basis	NNS
cord-326257-rcv8sh22	123	13	reflect	reflect	VBP
cord-326257-rcv8sh22	123	14	the	the	DT
cord-326257-rcv8sh22	123	15	progressive	progressive	JJ
cord-326257-rcv8sh22	123	16	depletion	depletion	NN
cord-326257-rcv8sh22	123	17	of	of	IN
cord-326257-rcv8sh22	123	18	C	c	NN
cord-326257-rcv8sh22	123	19	270	270	CD
cord-326257-rcv8sh22	123	20	residues	residue	NNS
cord-326257-rcv8sh22	123	21	and	and	CC
cord-326257-rcv8sh22	123	22	accumulation	accumulation	NN
cord-326257-rcv8sh22	123	23	of	of	IN
cord-326257-rcv8sh22	123	24	U	U	NNP
cord-326257-rcv8sh22	123	25	's	's	POS
cord-326257-rcv8sh22	123	26	by	by	IN
cord-326257-rcv8sh22	123	27	the	the	DT
cord-326257-rcv8sh22	123	28	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	123	29	-	-	HYPH
cord-326257-rcv8sh22	123	30	like	like	JJ
cord-326257-rcv8sh22	123	31	mutational	mutational	JJ
cord-326257-rcv8sh22	123	32	process	process	NN
cord-326257-rcv8sh22	123	33	on	on	IN
cord-326257-rcv8sh22	123	34	the	the	DT
cord-326257-rcv8sh22	123	35	genomic	genomic	NN
cord-326257-rcv8sh22	123	36	(	(	-LRB-
cord-326257-rcv8sh22	123	37	+	+	CC
cord-326257-rcv8sh22	123	38	)	)	-RRB-
cord-326257-rcv8sh22	123	39	strand	strand	NN
cord-326257-rcv8sh22	123	40	of	of	IN
cord-326257-rcv8sh22	123	41	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	123	42	.	.	.
cord-326257-rcv8sh22	124	1	Culminating	culminate	VBG
cord-326257-rcv8sh22	124	2	in	in	IN
cord-326257-rcv8sh22	124	3	the	the	DT
cord-326257-rcv8sh22	124	4	compositionally	compositionally	RB
cord-326257-rcv8sh22	124	5	highly	highly	RB
cord-326257-rcv8sh22	124	6	abnormal	abnormal	JJ
cord-326257-rcv8sh22	124	7	HKU1	HKU1	NNP
cord-326257-rcv8sh22	124	8	sequences	sequence	NNS
cord-326257-rcv8sh22	124	9	(	(	-LRB-
cord-326257-rcv8sh22	124	10	32	32	CD
cord-326257-rcv8sh22	124	11	)	)	-RRB-
cord-326257-rcv8sh22	124	12	,	,	,
cord-326257-rcv8sh22	124	13	this	this	DT
cord-326257-rcv8sh22	124	14	appears	appear	VBZ
cord-326257-rcv8sh22	124	15	to	to	TO
cord-326257-rcv8sh22	124	16	have	have	VB
cord-326257-rcv8sh22	124	17	driven	drive	VBN
cord-326257-rcv8sh22	124	18	down	down	RP
cord-326257-rcv8sh22	124	19	the	the	DT
cord-326257-rcv8sh22	124	20	G+C	G+C	NNP
cord-326257-rcv8sh22	124	21	content	content	NN
cord-326257-rcv8sh22	124	22	of	of	IN
cord-326257-rcv8sh22	124	23	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	124	24	as	as	RB
cord-326257-rcv8sh22	124	25	low	low	JJ
cord-326257-rcv8sh22	124	26	as	as	IN
cord-326257-rcv8sh22	124	27	32	32	CD
cord-326257-rcv8sh22	124	28	%	%	NN
cord-326257-rcv8sh22	124	29	while	while	IN
cord-326257-rcv8sh22	124	30	remarkably	remarkably	RB
cord-326257-rcv8sh22	124	31	leaving	leave	VBG
cord-326257-rcv8sh22	124	32	G	g	NN
cord-326257-rcv8sh22	124	33	and	and	CC
cord-326257-rcv8sh22	124	34	A	a	DT
cord-326257-rcv8sh22	124	35	frequencies	frequency	NNS
cord-326257-rcv8sh22	124	36	more	more	RBR
cord-326257-rcv8sh22	124	37	or	or	CC
cord-326257-rcv8sh22	124	38	less	less	RBR
cord-326257-rcv8sh22	124	39	unaltered	unaltered	JJ
cord-326257-rcv8sh22	124	40	(	(	-LRB-
cord-326257-rcv8sh22	124	41	Fig	Fig	NNP
cord-326257-rcv8sh22	124	42	.	.	NNP
cord-326257-rcv8sh22	124	43	7	7	CD
cord-326257-rcv8sh22	124	44	)	)	-RRB-
cord-326257-rcv8sh22	124	45	.	.	.
cord-326257-rcv8sh22	125	1	Intriguingly	intriguingly	RB
cord-326257-rcv8sh22	125	2	,	,	,
cord-326257-rcv8sh22	125	3	the	the	DT
cord-326257-rcv8sh22	125	4	bat	bat	NN
cord-326257-rcv8sh22	125	5	-	-	HYPH
cord-326257-rcv8sh22	125	6	derived	derive	VBN
cord-326257-rcv8sh22	125	7	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	125	8	along	along	IN
cord-326257-rcv8sh22	125	9	with	with	IN
cord-326257-rcv8sh22	125	10	the	the	DT
cord-326257-rcv8sh22	125	11	recently	recently	RB
cord-326257-rcv8sh22	125	12	zoonotically	zoonotically	RB
cord-326257-rcv8sh22	125	13	transferred	transfer	VBD
cord-326257-rcv8sh22	125	14	viruses	virus	NNS
cord-326257-rcv8sh22	125	15	into	into	IN
cord-326257-rcv8sh22	125	16	humans	human	NNS
cord-326257-rcv8sh22	125	17	show	show	VBP
cord-326257-rcv8sh22	125	18	the	the	DT
cord-326257-rcv8sh22	125	19	least	least	JJS
cord-326257-rcv8sh22	125	20	degree	degree	NN
cord-326257-rcv8sh22	125	21	of	of	IN
cord-326257-rcv8sh22	125	22	compositional	compositional	JJ
cord-326257-rcv8sh22	125	23	275	275	CD
cord-326257-rcv8sh22	125	24	asymmetry	asymmetry	NN
cord-326257-rcv8sh22	125	25	.	.	.
cord-326257-rcv8sh22	126	1	The	the	DT
cord-326257-rcv8sh22	126	2	expansions	expansion	NNS
cord-326257-rcv8sh22	126	3	in	in	IN
cord-326257-rcv8sh22	126	4	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	126	5	gene	gene	NN
cord-326257-rcv8sh22	126	6	numbers	number	NNS
cord-326257-rcv8sh22	126	7	,	,	,
cord-326257-rcv8sh22	126	8	extensive	extensive	JJ
cord-326257-rcv8sh22	126	9	positive	positive	JJ
cord-326257-rcv8sh22	126	10	selection	selection	NN
cord-326257-rcv8sh22	126	11	and	and	CC
cord-326257-rcv8sh22	126	12	the	the	DT
cord-326257-rcv8sh22	126	13	consequent	consequent	JJ
cord-326257-rcv8sh22	126	14	variability	variability	NN
cord-326257-rcv8sh22	126	15	in	in	IN
cord-326257-rcv8sh22	126	16	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	126	17	nucleic	nucleic	JJ
cord-326257-rcv8sh22	126	18	acid	acid	NN
cord-326257-rcv8sh22	126	19	targeting	target	VBG
cord-326257-rcv8sh22	126	20	(	(	-LRB-
cord-326257-rcv8sh22	126	21	20	20	CD
cord-326257-rcv8sh22	126	22	)	)	-RRB-
cord-326257-rcv8sh22	126	23	may	may	MD
cord-326257-rcv8sh22	126	24	indeed	indeed	RB
cord-326257-rcv8sh22	126	25	create	create	VB
cord-326257-rcv8sh22	126	26	distinct	distinct	JJ
cord-326257-rcv8sh22	126	27	selection	selection	NN
cord-326257-rcv8sh22	126	28	pressures	pressure	NNS
cord-326257-rcv8sh22	126	29	on	on	IN
cord-326257-rcv8sh22	126	30	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	126	31	in	in	IN
cord-326257-rcv8sh22	126	32	different	different	JJ
cord-326257-rcv8sh22	126	33	hosts	host	NNS
cord-326257-rcv8sh22	126	34	.	.	.
cord-326257-rcv8sh22	127	1	The	the	DT
cord-326257-rcv8sh22	127	2	immediate	immediate	JJ
cord-326257-rcv8sh22	127	3	appearance	appearance	NN
cord-326257-rcv8sh22	127	4	of	of	IN
cord-326257-rcv8sh22	127	5	C->U	C->U	NNP
cord-326257-rcv8sh22	127	6	hypermutation	hypermutation	NN
cord-326257-rcv8sh22	127	7	in	in	IN
cord-326257-rcv8sh22	127	8	SARS	SARS	NNP
cord-326257-rcv8sh22	127	9	-	-	HYPH
cord-326257-rcv8sh22	127	10	CoV-2	CoV-2	NNP
cord-326257-rcv8sh22	127	11	and	and	CC
cord-326257-rcv8sh22	127	12	SARS	SARS	NNP
cord-326257-rcv8sh22	127	13	-	-	HYPH
cord-326257-rcv8sh22	127	14	CoV	CoV	NNP
cord-326257-rcv8sh22	127	15	280	280	CD
cord-326257-rcv8sh22	127	16	genomes	genome	NNS
cord-326257-rcv8sh22	127	17	in	in	IN
cord-326257-rcv8sh22	127	18	humans	human	NNS
cord-326257-rcv8sh22	127	19	may	may	MD
cord-326257-rcv8sh22	127	20	therefore	therefore	RB
cord-326257-rcv8sh22	127	21	represent	represent	VB
cord-326257-rcv8sh22	127	22	the	the	DT
cord-326257-rcv8sh22	127	23	initial	initial	JJ
cord-326257-rcv8sh22	127	24	effects	effect	NNS
cord-326257-rcv8sh22	127	25	of	of	IN
cord-326257-rcv8sh22	127	26	replication	replication	NN
cord-326257-rcv8sh22	127	27	in	in	IN
cord-326257-rcv8sh22	127	28	a	a	DT
cord-326257-rcv8sh22	127	29	more	more	RBR
cord-326257-rcv8sh22	127	30	hostile	hostile	JJ
cord-326257-rcv8sh22	127	31	internal	internal	JJ
cord-326257-rcv8sh22	127	32	cellular	cellular	JJ
cord-326257-rcv8sh22	127	33	environment	environment	NN
cord-326257-rcv8sh22	127	34	than	than	IN
cord-326257-rcv8sh22	127	35	to	to	TO
cord-326257-rcv8sh22	127	36	be	be	VB
cord-326257-rcv8sh22	127	37	found	find	VBN
cord-326257-rcv8sh22	127	38	in	in	IN
cord-326257-rcv8sh22	127	39	a	a	DT
cord-326257-rcv8sh22	127	40	better	well	JJR
cord-326257-rcv8sh22	127	41	co	co	JJ
cord-326257-rcv8sh22	127	42	-	-	JJ
cord-326257-rcv8sh22	127	43	oadapted	oadapted	JJ
cord-326257-rcv8sh22	127	44	,	,	,
cord-326257-rcv8sh22	127	45	virus	virus	NN
cord-326257-rcv8sh22	127	46	-	-	HYPH
cord-326257-rcv8sh22	127	47	tolerised	tolerise	VBN
cord-326257-rcv8sh22	127	48	immune	immune	JJ
cord-326257-rcv8sh22	127	49	system	system	NN
cord-326257-rcv8sh22	127	50	of	of	IN
cord-326257-rcv8sh22	127	51	a	a	DT
cord-326257-rcv8sh22	127	52	bat	bat	NN
cord-326257-rcv8sh22	127	53	(	(	-LRB-
cord-326257-rcv8sh22	127	54	34	34	CD
cord-326257-rcv8sh22	127	55	)	)	-RRB-
cord-326257-rcv8sh22	127	56	.	.	.
cord-326257-rcv8sh22	128	1	Zoonotic	zoonotic	JJ
cord-326257-rcv8sh22	128	2	origins	origin	NNS
cord-326257-rcv8sh22	128	3	are	be	VBP
cord-326257-rcv8sh22	128	4	suspected	suspect	VBN
cord-326257-rcv8sh22	128	5	for	for	IN
cord-326257-rcv8sh22	128	6	other	other	JJ
cord-326257-rcv8sh22	128	7	human	human	JJ
cord-326257-rcv8sh22	128	8	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	128	9	but	but	CC
cord-326257-rcv8sh22	128	10	at	at	IN
cord-326257-rcv8sh22	128	11	more	more	JJR
cord-326257-rcv8sh22	128	12	remote	remote	JJ
cord-326257-rcv8sh22	128	13	times	time	NNS
cord-326257-rcv8sh22	128	14	(	(	-LRB-
cord-326257-rcv8sh22	128	15	35	35	CD
cord-326257-rcv8sh22	128	16	)	)	-RRB-
cord-326257-rcv8sh22	128	17	;	;	:
cord-326257-rcv8sh22	128	18	perhaps	perhaps	RB
cord-326257-rcv8sh22	128	19	they	-PRON-	PRP
cord-326257-rcv8sh22	128	20	have	have	VBP
cord-326257-rcv8sh22	128	21	taken	take	VBN
cord-326257-rcv8sh22	128	22	their	-PRON-	PRP$
cord-326257-rcv8sh22	128	23	mutational	mutational	JJ
cord-326257-rcv8sh22	128	24	and	and	CC
cord-326257-rcv8sh22	128	25	adaptive	adaptive	JJ
cord-326257-rcv8sh22	128	26	journeys	journey	NNS
cord-326257-rcv8sh22	128	27	already	already	RB
cord-326257-rcv8sh22	128	28	.	.	.
cord-326257-rcv8sh22	129	1	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	129	2	and	and	CC
cord-326257-rcv8sh22	129	3	relatives	relative	NNS
cord-326257-rcv8sh22	129	4	infecting	infect	VBG
cord-326257-rcv8sh22	129	5	other	other	JJ
cord-326257-rcv8sh22	129	6	species	specie	NNS
cord-326257-rcv8sh22	129	7	(	(	-LRB-
cord-326257-rcv8sh22	129	8	blue	blue	JJ
cord-326257-rcv8sh22	129	9	circles	circle	NNS
cord-326257-rcv8sh22	129	10	)	)	-RRB-
cord-326257-rcv8sh22	129	11	and	and	CC
cord-326257-rcv8sh22	129	12	a	a	DT
cord-326257-rcv8sh22	129	13	collection	collection	NN
cord-326257-rcv8sh22	129	14	of	of	IN
cord-326257-rcv8sh22	129	15	bat	bat	NN
cord-326257-rcv8sh22	129	16	SARS	SARS	NNP
cord-326257-rcv8sh22	129	17	-	-	HYPH
cord-326257-rcv8sh22	129	18	like	like	JJ
cord-326257-rcv8sh22	129	19	viruses	virus	NNS
cord-326257-rcv8sh22	129	20	(	(	-LRB-
cord-326257-rcv8sh22	129	21	grey	grey	NNP
cord-326257-rcv8sh22	129	22	circle	circle	NNP
cord-326257-rcv8sh22	129	23	)	)	-RRB-
cord-326257-rcv8sh22	129	24	.	.	.
cord-326257-rcv8sh22	130	1	A	a	DT
cord-326257-rcv8sh22	130	2	power	power	NN
cord-326257-rcv8sh22	130	3	law	law	NN
cord-326257-rcv8sh22	130	4	line	line	NN
cord-326257-rcv8sh22	130	5	of	of	IN
cord-326257-rcv8sh22	130	6	best	good	JJS
cord-326257-rcv8sh22	130	7	fit	fit	NN
cord-326257-rcv8sh22	130	8	showed	show	VBD
cord-326257-rcv8sh22	130	9	a	a	DT
cord-326257-rcv8sh22	130	10	significant	significant	JJ
cord-326257-rcv8sh22	130	11	correlation	correlation	NN
cord-326257-rcv8sh22	130	12	between	between	IN
cord-326257-rcv8sh22	130	13	divergence	divergence	NN
cord-326257-rcv8sh22	130	14	and	and	CC
cord-326257-rcv8sh22	130	15	dN	dN	NNP
cord-326257-rcv8sh22	130	16	/	/	SYM
cord-326257-rcv8sh22	130	17	dS	dS	NNP
cord-326257-rcv8sh22	130	18	ratio	ratio	NN
cord-326257-rcv8sh22	130	19	(	(	-LRB-
cord-326257-rcv8sh22	130	20	p	p	NN
cord-326257-rcv8sh22	130	21	=	=	SYM
cord-326257-rcv8sh22	130	22	0.000006	0.000006	CD
cord-326257-rcv8sh22	130	23	)	)	-RRB-
cord-326257-rcv8sh22	130	24	.	.	.
cord-326257-rcv8sh22	131	1	Relationship	relationship	NN
cord-326257-rcv8sh22	131	2	between	between	IN
cord-326257-rcv8sh22	131	3	G+C	G+C	NNP
cord-326257-rcv8sh22	131	4	content	content	NN
cord-326257-rcv8sh22	131	5	and	and	CC
cord-326257-rcv8sh22	131	6	frequencies	frequency	NNS
cord-326257-rcv8sh22	131	7	of	of	IN
cord-326257-rcv8sh22	131	8	individual	individual	JJ
cord-326257-rcv8sh22	131	9	bases	basis	NNS
cord-326257-rcv8sh22	131	10	in	in	IN
cord-326257-rcv8sh22	131	11	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	131	12	.	.	.
cord-326257-rcv8sh22	132	1	The	the	DT
cord-326257-rcv8sh22	132	2	associations	association	NNS
cord-326257-rcv8sh22	132	3	between	between	IN
cord-326257-rcv8sh22	132	4	C	c	NN
cord-326257-rcv8sh22	132	5	depletion	depletion	NN
cord-326257-rcv8sh22	132	6	and	and	CC
cord-326257-rcv8sh22	132	7	U	u	NN
cord-326257-rcv8sh22	132	8	enrichment	enrichment	NN
cord-326257-rcv8sh22	132	9	with	with	IN
cord-326257-rcv8sh22	132	10	G+C	G+C	NNP
cord-326257-rcv8sh22	132	11	content	content	NN
cord-326257-rcv8sh22	132	12	were	be	VBD
cord-326257-rcv8sh22	132	13	both	both	DT
cord-326257-rcv8sh22	132	14	significant	significant	JJ
cord-326257-rcv8sh22	132	15	by	by	IN
cord-326257-rcv8sh22	132	16	585	585	CD
cord-326257-rcv8sh22	132	17	linear	linear	JJ
cord-326257-rcv8sh22	132	18	regression	regression	NN
cord-326257-rcv8sh22	132	19	at	at	IN
cord-326257-rcv8sh22	132	20	p	p	NN
cord-326257-rcv8sh22	132	21	=	=	SYM
cord-326257-rcv8sh22	132	22	5	5	CD
cord-326257-rcv8sh22	132	23	x	x	SYM
cord-326257-rcv8sh22	132	24	10	10	CD
cord-326257-rcv8sh22	132	25	-7	-7	CD
cord-326257-rcv8sh22	132	26	and	and	CC
cord-326257-rcv8sh22	132	27	p	p	NN
cord-326257-rcv8sh22	132	28	=	=	SYM
cord-326257-rcv8sh22	132	29	5	5	CD
cord-326257-rcv8sh22	132	30	x	x	SYM
cord-326257-rcv8sh22	132	31	10	10	CD
cord-326257-rcv8sh22	132	32	-6	-6	NNP
cord-326257-rcv8sh22	132	33	respectively	respectively	RB
cord-326257-rcv8sh22	132	34	.	.	.
cord-326257-rcv8sh22	133	1	No	no	DT
cord-326257-rcv8sh22	133	2	significant	significant	JJ
cord-326257-rcv8sh22	133	3	associations	association	NNS
cord-326257-rcv8sh22	133	4	were	be	VBD
cord-326257-rcv8sh22	133	5	observed	observe	VBN
cord-326257-rcv8sh22	133	6	between	between	IN
cord-326257-rcv8sh22	133	7	G+C	G+C	NNP
cord-326257-rcv8sh22	133	8	content	content	NN
cord-326257-rcv8sh22	133	9	and	and	CC
cord-326257-rcv8sh22	133	10	G	g	NN
cord-326257-rcv8sh22	133	11	(	(	-LRB-
cord-326257-rcv8sh22	133	12	p	p	NN
cord-326257-rcv8sh22	133	13	=	=	SYM
cord-326257-rcv8sh22	133	14	0.05	0.05	CD
cord-326257-rcv8sh22	133	15	)	)	-RRB-
cord-326257-rcv8sh22	133	16	or	or	CC
cord-326257-rcv8sh22	133	17	A	a	NN
cord-326257-rcv8sh22	133	18	(	(	-LRB-
cord-326257-rcv8sh22	133	19	p	p	NN
cord-326257-rcv8sh22	133	20	=	=	SYM
cord-326257-rcv8sh22	133	21	0.62	0.62	CD
cord-326257-rcv8sh22	133	22	)	)	-RRB-
cord-326257-rcv8sh22	133	23	frequencies	frequency	NNS
cord-326257-rcv8sh22	133	24	.	.	.
cord-326257-rcv8sh22	134	1	Arrows	arrow	NNS
cord-326257-rcv8sh22	134	2	are	be	VBP
cord-326257-rcv8sh22	134	3	colour	colour	NN
cord-326257-rcv8sh22	134	4	coded	code	VBN
cord-326257-rcv8sh22	134	5	as	as	IN
cord-326257-rcv8sh22	134	6	for	for	IN
cord-326257-rcv8sh22	134	7	Fig	Fig	NNP
cord-326257-rcv8sh22	134	8	.	.	.
cord-326257-rcv8sh22	135	1	1	1	LS
cord-326257-rcv8sh22	135	2	.	.	.
cord-326257-rcv8sh22	136	1	Early	early	JJ
cord-326257-rcv8sh22	136	2	Transmission	Transmission	NNP
cord-326257-rcv8sh22	136	3	Dynamics	Dynamics	NNPS
cord-326257-rcv8sh22	136	4	in	in	IN
cord-326257-rcv8sh22	136	5	Wuhan	Wuhan	NNP
cord-326257-rcv8sh22	136	6	,	,	,
cord-326257-rcv8sh22	136	7	China	China	NNP
cord-326257-rcv8sh22	136	8	,	,	,
cord-326257-rcv8sh22	136	9	of	of	IN
cord-326257-rcv8sh22	136	10	Novel	Novel	NNP
cord-326257-rcv8sh22	136	11	Coronavirus	Coronavirus	NNP
cord-326257-rcv8sh22	136	12	-	-	HYPH
cord-326257-rcv8sh22	136	13	Infected	infect	VBN
cord-326257-rcv8sh22	136	14	Pneumonia	Pneumonia	NNP
cord-326257-rcv8sh22	136	15	A	A	NNP
cord-326257-rcv8sh22	136	16	Novel	Novel	NNP
cord-326257-rcv8sh22	136	17	Coronavirus	Coronavirus	NNP
cord-326257-rcv8sh22	136	18	from	from	IN
cord-326257-rcv8sh22	136	19	Patients	patient	NNS
cord-326257-rcv8sh22	136	20	with	with	IN
cord-326257-rcv8sh22	136	21	Pneumonia	Pneumonia	NNP
cord-326257-rcv8sh22	136	22	in	in	IN
cord-326257-rcv8sh22	136	23	China	China	NNP
cord-326257-rcv8sh22	137	1	A	a	DT
cord-326257-rcv8sh22	137	2	new	new	JJ
cord-326257-rcv8sh22	137	3	325	325	CD
cord-326257-rcv8sh22	137	4	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	137	5	associated	associate	VBN
cord-326257-rcv8sh22	137	6	with	with	IN
cord-326257-rcv8sh22	137	7	human	human	JJ
cord-326257-rcv8sh22	137	8	respiratory	respiratory	JJ
cord-326257-rcv8sh22	137	9	disease	disease	NN
cord-326257-rcv8sh22	137	10	in	in	IN
cord-326257-rcv8sh22	137	11	China	China	NNP
cord-326257-rcv8sh22	137	12	Coronaviruses	Coronaviruses	NNP
cord-326257-rcv8sh22	137	13	lacking	lack	VBG
cord-326257-rcv8sh22	137	14	exoribonuclease	exoribonuclease	NN
cord-326257-rcv8sh22	137	15	activity	activity	NN
cord-326257-rcv8sh22	137	16	are	be	VBP
cord-326257-rcv8sh22	137	17	susceptible	susceptible	JJ
cord-326257-rcv8sh22	137	18	to	to	IN
cord-326257-rcv8sh22	137	19	lethal	lethal	JJ
cord-326257-rcv8sh22	137	20	mutagenesis	mutagenesis	NN
cord-326257-rcv8sh22	137	21	:	:	:
cord-326257-rcv8sh22	138	1	evidence	evidence	NN
cord-326257-rcv8sh22	138	2	for	for	IN
cord-326257-rcv8sh22	138	3	proofreading	proofread	VBG
cord-326257-rcv8sh22	138	4	and	and	CC
cord-326257-rcv8sh22	138	5	potential	potential	JJ
cord-326257-rcv8sh22	138	6	therapeutics	therapeutic	NNS
cord-326257-rcv8sh22	138	7	Infidelity	Infidelity	NNP
cord-326257-rcv8sh22	138	8	of	of	IN
cord-326257-rcv8sh22	138	9	SARS	SARS	NNP
cord-326257-rcv8sh22	138	10	-	-	HYPH
cord-326257-rcv8sh22	138	11	CoV	CoV	NNP
cord-326257-rcv8sh22	138	12	Nsp14-exonuclease	Nsp14-exonuclease	NNP
cord-326257-rcv8sh22	138	13	mutant	mutant	JJ
cord-326257-rcv8sh22	138	14	virus	virus	NN
cord-326257-rcv8sh22	138	15	replication	replication	NN
cord-326257-rcv8sh22	138	16	is	be	VBZ
cord-326257-rcv8sh22	138	17	revealed	reveal	VBN
cord-326257-rcv8sh22	138	18	by	by	IN
cord-326257-rcv8sh22	138	19	complete	complete	JJ
cord-326257-rcv8sh22	138	20	genome	genome	NN
cord-326257-rcv8sh22	138	21	sequencing	sequencing	NN
cord-326257-rcv8sh22	138	22	High	high	JJ
cord-326257-rcv8sh22	138	23	fidelity	fidelity	NN
cord-326257-rcv8sh22	138	24	of	of	IN
cord-326257-rcv8sh22	138	25	murine	murine	JJ
cord-326257-rcv8sh22	138	26	hepatitis	hepatitis	NN
cord-326257-rcv8sh22	138	27	virus	virus	NN
cord-326257-rcv8sh22	138	28	replication	replication	NN
cord-326257-rcv8sh22	138	29	is	be	VBZ
cord-326257-rcv8sh22	138	30	decreased	decrease	VBN
cord-326257-rcv8sh22	138	31	in	in	IN
cord-326257-rcv8sh22	138	32	nsp14	nsp14	CD
cord-326257-rcv8sh22	138	33	exoribonuclease	exoribonuclease	NNP
cord-326257-rcv8sh22	138	34	mutants	mutant	NNS
cord-326257-rcv8sh22	138	35	Severe	severe	JJ
cord-326257-rcv8sh22	138	36	acute	acute	JJ
cord-326257-rcv8sh22	138	37	respiratory	respiratory	JJ
cord-326257-rcv8sh22	138	38	syndrome	syndrome	NN
cord-326257-rcv8sh22	138	39	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	138	40	sequence	sequence	NN
cord-326257-rcv8sh22	138	41	characteristics	characteristic	NNS
cord-326257-rcv8sh22	138	42	and	and	CC
cord-326257-rcv8sh22	138	43	evolutionary	evolutionary	JJ
cord-326257-rcv8sh22	138	44	rate	rate	NN
cord-326257-rcv8sh22	138	45	estimate	estimate	NN
cord-326257-rcv8sh22	138	46	from	from	IN
cord-326257-rcv8sh22	138	47	maximum	maximum	JJ
cord-326257-rcv8sh22	138	48	likelihood	likelihood	NN
cord-326257-rcv8sh22	138	49	analysis	analysis	NN
cord-326257-rcv8sh22	139	1	Genetic	genetic	JJ
cord-326257-rcv8sh22	139	2	evolution	evolution	NN
cord-326257-rcv8sh22	139	3	and	and	CC
cord-326257-rcv8sh22	139	4	tropism	tropism	NN
cord-326257-rcv8sh22	139	5	of	of	IN
cord-326257-rcv8sh22	139	6	transmissible	transmissible	JJ
cord-326257-rcv8sh22	139	7	gastroenteritis	gastroenteritis	NN
cord-326257-rcv8sh22	139	8	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	139	9	Characterization	characterization	NN
cord-326257-rcv8sh22	139	10	and	and	CC
cord-326257-rcv8sh22	139	11	evolution	evolution	NN
cord-326257-rcv8sh22	139	12	of	of	IN
cord-326257-rcv8sh22	139	13	porcine	porcine	JJ
cord-326257-rcv8sh22	139	14	deltacoronavirus	deltacoronavirus	NN
cord-326257-rcv8sh22	139	15	in	in	IN
cord-326257-rcv8sh22	139	16	the	the	DT
cord-326257-rcv8sh22	139	17	United	United	NNP
cord-326257-rcv8sh22	139	18	States	States	NNP
cord-326257-rcv8sh22	139	19	Spread	Spread	NNP
cord-326257-rcv8sh22	139	20	,	,	,
cord-326257-rcv8sh22	139	21	circulation	circulation	NN
cord-326257-rcv8sh22	139	22	,	,	,
cord-326257-rcv8sh22	139	23	and	and	CC
cord-326257-rcv8sh22	139	24	evolution	evolution	NN
cord-326257-rcv8sh22	139	25	of	of	IN
cord-326257-rcv8sh22	139	26	the	the	DT
cord-326257-rcv8sh22	139	27	Middle	Middle	NNP
cord-326257-rcv8sh22	139	28	East	East	NNP
cord-326257-rcv8sh22	139	29	respiratory	respiratory	JJ
cord-326257-rcv8sh22	139	30	syndrome	syndrome	NN
cord-326257-rcv8sh22	139	31	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	139	32	Analysis	Analysis	NNP
cord-326257-rcv8sh22	139	33	of	of	IN
cord-326257-rcv8sh22	139	34	error	error	NN
cord-326257-rcv8sh22	139	35	profiles	profile	NNS
cord-326257-rcv8sh22	139	36	in	in	IN
cord-326257-rcv8sh22	139	37	deep	deep	JJ
cord-326257-rcv8sh22	139	38	next	next	JJ
cord-326257-rcv8sh22	139	39	-	-	HYPH
cord-326257-rcv8sh22	139	40	generation	generation	NN
cord-326257-rcv8sh22	139	41	sequencing	sequencing	NN
cord-326257-rcv8sh22	139	42	data	datum	NNS
cord-326257-rcv8sh22	140	1	Adenosine	adenosine	NN
cord-326257-rcv8sh22	140	2	deaminases	deaminase	NNS
cord-326257-rcv8sh22	140	3	acting	act	VBG
cord-326257-rcv8sh22	140	4	on	on	IN
cord-326257-rcv8sh22	140	5	RNA	RNA	NNP
cord-326257-rcv8sh22	140	6	(	(	-LRB-
cord-326257-rcv8sh22	140	7	ADARs	adar	NNS
cord-326257-rcv8sh22	140	8	)	)	-RRB-
cord-326257-rcv8sh22	140	9	are	be	VBP
cord-326257-rcv8sh22	140	10	both	both	DT
cord-326257-rcv8sh22	140	11	antiviral	antiviral	JJ
cord-326257-rcv8sh22	140	12	and	and	CC
cord-326257-rcv8sh22	140	13	proviral	proviral	JJ
cord-326257-rcv8sh22	141	1	The	the	DT
cord-326257-rcv8sh22	141	2	cytidine	cytidine	NN
cord-326257-rcv8sh22	141	3	deaminase	deaminase	NN
cord-326257-rcv8sh22	141	4	CEM15	CEM15	NNP
cord-326257-rcv8sh22	141	5	induces	induce	VBZ
cord-326257-rcv8sh22	141	6	hypermutation	hypermutation	NN
cord-326257-rcv8sh22	141	7	in	in	IN
cord-326257-rcv8sh22	141	8	newly	newly	RB
cord-326257-rcv8sh22	141	9	synthesized	synthesize	VBN
cord-326257-rcv8sh22	141	10	HIV-1	HIV-1	NNP
cord-326257-rcv8sh22	141	11	DNA	DNA	NNP
cord-326257-rcv8sh22	141	12	Broad	Broad	NNP
cord-326257-rcv8sh22	141	13	antiretroviral	antiretroviral	JJ
cord-326257-rcv8sh22	141	14	defence	defence	NN
cord-326257-rcv8sh22	141	15	by	by	IN
cord-326257-rcv8sh22	141	16	human	human	JJ
cord-326257-rcv8sh22	141	17	APOBEC3	APOBEC3	NNP
cord-326257-rcv8sh22	141	18	G	g	NN
cord-326257-rcv8sh22	141	19	through	through	IN
cord-326257-rcv8sh22	141	20	lethal	lethal	JJ
cord-326257-rcv8sh22	141	21	editing	editing	NN
cord-326257-rcv8sh22	141	22	of	of	IN
cord-326257-rcv8sh22	141	23	nascent	nascent	JJ
cord-326257-rcv8sh22	141	24	reverse	reverse	NN
cord-326257-rcv8sh22	141	25	transcripts	transcript	NNS
cord-326257-rcv8sh22	141	26	DNA	dna	NN
cord-326257-rcv8sh22	141	27	deamination	deamination	NN
cord-326257-rcv8sh22	141	28	mediates	mediate	VBZ
cord-326257-rcv8sh22	141	29	innate	innate	JJ
cord-326257-rcv8sh22	141	30	immunity	immunity	NN
cord-326257-rcv8sh22	141	31	to	to	IN
cord-326257-rcv8sh22	141	32	retroviral	retroviral	JJ
cord-326257-rcv8sh22	141	33	infection	infection	NN
cord-326257-rcv8sh22	142	1	G-->A	g-->a	JJ
cord-326257-rcv8sh22	142	2	hypermutation	hypermutation	NN
cord-326257-rcv8sh22	142	3	of	of	IN
cord-326257-rcv8sh22	142	4	the	the	DT
cord-326257-rcv8sh22	142	5	human	human	JJ
cord-326257-rcv8sh22	142	6	immunodeficiency	immunodeficiency	NN
cord-326257-rcv8sh22	142	7	virus	virus	NN
cord-326257-rcv8sh22	142	8	type	type	NN
cord-326257-rcv8sh22	142	9	1	1	CD
cord-326257-rcv8sh22	142	10	genome	genome	NN
cord-326257-rcv8sh22	142	11	:	:	:
cord-326257-rcv8sh22	142	12	evidence	evidence	NN
cord-326257-rcv8sh22	142	13	for	for	IN
cord-326257-rcv8sh22	142	14	dCTP	dctp	JJ
cord-326257-rcv8sh22	142	15	pool	pool	NN
cord-326257-rcv8sh22	142	16	imbalance	imbalance	NN
cord-326257-rcv8sh22	142	17	during	during	IN
cord-326257-rcv8sh22	142	18	reverse	reverse	JJ
cord-326257-rcv8sh22	142	19	transcription	transcription	NN
cord-326257-rcv8sh22	142	20	APOBECs	apobec	NNS
cord-326257-rcv8sh22	142	21	and	and	CC
cord-326257-rcv8sh22	142	22	virus	virus	NN
cord-326257-rcv8sh22	142	23	restriction	restriction	NN
cord-326257-rcv8sh22	142	24	Evolution	evolution	NN
cord-326257-rcv8sh22	142	25	of	of	IN
cord-326257-rcv8sh22	142	26	the	the	DT
cord-326257-rcv8sh22	142	27	primate	primate	JJ
cord-326257-rcv8sh22	142	28	APOBEC3A	apobec3a	JJ
cord-326257-rcv8sh22	142	29	cytidine	cytidine	NN
cord-326257-rcv8sh22	142	30	deaminase	deaminase	NN
cord-326257-rcv8sh22	142	31	gene	gene	NN
cord-326257-rcv8sh22	142	32	and	and	CC
cord-326257-rcv8sh22	142	33	identification	identification	NN
cord-326257-rcv8sh22	142	34	of	of	IN
cord-326257-rcv8sh22	142	35	related	related	JJ
cord-326257-rcv8sh22	142	36	coding	coding	NN
cord-326257-rcv8sh22	142	37	regions	region	NNS
cord-326257-rcv8sh22	143	1	Ancient	ancient	JJ
cord-326257-rcv8sh22	143	2	adaptive	adaptive	JJ
cord-326257-rcv8sh22	143	3	evolution	evolution	NN
cord-326257-rcv8sh22	143	4	of	of	IN
cord-326257-rcv8sh22	143	5	the	the	DT
cord-326257-rcv8sh22	143	6	primate	primate	JJ
cord-326257-rcv8sh22	143	7	antiviral	antiviral	JJ
cord-326257-rcv8sh22	143	8	375	375	CD
cord-326257-rcv8sh22	143	9	DNA	dna	NN
cord-326257-rcv8sh22	143	10	-	-	HYPH
cord-326257-rcv8sh22	143	11	editing	editing	NN
cord-326257-rcv8sh22	143	12	enzyme	enzyme	NN
cord-326257-rcv8sh22	144	1	APOBEC3	APOBEC3	NNP
cord-326257-rcv8sh22	144	2	G	G	NNP
cord-326257-rcv8sh22	144	3	APOBEC3B	APOBEC3B	NNP
cord-326257-rcv8sh22	144	4	and	and	CC
cord-326257-rcv8sh22	144	5	APOBEC3F	APOBEC3F	NNP
cord-326257-rcv8sh22	144	6	inhibit	inhibit	VB
cord-326257-rcv8sh22	144	7	L1	L1	NNP
cord-326257-rcv8sh22	144	8	retrotransposition	retrotransposition	NN
cord-326257-rcv8sh22	144	9	by	by	IN
cord-326257-rcv8sh22	144	10	a	a	DT
cord-326257-rcv8sh22	144	11	DNA	dna	NN
cord-326257-rcv8sh22	144	12	deamination	deamination	NN
cord-326257-rcv8sh22	144	13	-	-	HYPH
cord-326257-rcv8sh22	144	14	independent	independent	JJ
cord-326257-rcv8sh22	144	15	mechanism	mechanism	NN
cord-326257-rcv8sh22	144	16	APOBEC	APOBEC	NNP
cord-326257-rcv8sh22	144	17	-	-	HYPH
cord-326257-rcv8sh22	144	18	mediated	mediate	VBN
cord-326257-rcv8sh22	144	19	editing	editing	NN
cord-326257-rcv8sh22	144	20	of	of	IN
cord-326257-rcv8sh22	144	21	viral	viral	JJ
cord-326257-rcv8sh22	144	22	RNA	RNA	NNP
cord-326257-rcv8sh22	145	1	The	the	DT
cord-326257-rcv8sh22	145	2	innate	innate	JJ
cord-326257-rcv8sh22	145	3	antiviral	antiviral	JJ
cord-326257-rcv8sh22	145	4	factor	factor	NN
cord-326257-rcv8sh22	145	5	APOBEC3	apobec3	NN
cord-326257-rcv8sh22	145	6	G	g	NN
cord-326257-rcv8sh22	145	7	targets	target	NNS
cord-326257-rcv8sh22	145	8	replication	replication	NN
cord-326257-rcv8sh22	145	9	of	of	IN
cord-326257-rcv8sh22	145	10	measles	measle	NNS
cord-326257-rcv8sh22	145	11	,	,	,
cord-326257-rcv8sh22	145	12	mumps	mumps	NN
cord-326257-rcv8sh22	145	13	and	and	CC
cord-326257-rcv8sh22	145	14	respiratory	respiratory	JJ
cord-326257-rcv8sh22	145	15	syncytial	syncytial	JJ
cord-326257-rcv8sh22	145	16	viruses	virus	NNS
cord-326257-rcv8sh22	146	1	APOBEC3	APOBEC3	NNP
cord-326257-rcv8sh22	146	2	G	G	NNP
cord-326257-rcv8sh22	146	3	is	be	VBZ
cord-326257-rcv8sh22	146	4	a	a	DT
cord-326257-rcv8sh22	146	5	385	385	CD
cord-326257-rcv8sh22	146	6	restriction	restriction	NN
cord-326257-rcv8sh22	146	7	factor	factor	NN
cord-326257-rcv8sh22	146	8	of	of	IN
cord-326257-rcv8sh22	146	9	EV71	EV71	NNP
cord-326257-rcv8sh22	146	10	and	and	CC
cord-326257-rcv8sh22	146	11	mediator	mediator	NN
cord-326257-rcv8sh22	146	12	of	of	IN
cord-326257-rcv8sh22	146	13	IMB	IMB	NNP
cord-326257-rcv8sh22	146	14	-	-	HYPH
cord-326257-rcv8sh22	146	15	Z	Z	NNP
cord-326257-rcv8sh22	146	16	antiviral	antiviral	JJ
cord-326257-rcv8sh22	146	17	activity	activity	NN
cord-326257-rcv8sh22	146	18	APOBEC3-mediated	apobec3-mediated	CD
cord-326257-rcv8sh22	146	19	restriction	restriction	NN
cord-326257-rcv8sh22	146	20	of	of	IN
cord-326257-rcv8sh22	146	21	RNA	RNA	NNP
cord-326257-rcv8sh22	146	22	virus	virus	NN
cord-326257-rcv8sh22	146	23	replication	replication	NN
cord-326257-rcv8sh22	146	24	APOBEC3A	apobec3a	NN
cord-326257-rcv8sh22	146	25	cytidine	cytidine	NNP
cord-326257-rcv8sh22	146	26	deaminase	deaminase	NNP
cord-326257-rcv8sh22	146	27	induces	induce	VBZ
cord-326257-rcv8sh22	146	28	RNA	RNA	NNP
cord-326257-rcv8sh22	146	29	editing	editing	NN
cord-326257-rcv8sh22	146	30	in	in	IN
cord-326257-rcv8sh22	146	31	monocytes	monocyte	NNS
cord-326257-rcv8sh22	146	32	and	and	CC
cord-326257-rcv8sh22	146	33	macrophages	macrophage	NNS
cord-326257-rcv8sh22	146	34	Mitochondrial	mitochondrial	NN
cord-326257-rcv8sh22	147	1	hypoxic	hypoxic	JJ
cord-326257-rcv8sh22	147	2	stress	stress	NN
cord-326257-rcv8sh22	147	3	induces	induce	VBZ
cord-326257-rcv8sh22	147	4	widespread	widespread	JJ
cord-326257-rcv8sh22	147	5	RNA	RNA	NNP
cord-326257-rcv8sh22	147	6	editing	editing	NN
cord-326257-rcv8sh22	147	7	by	by	IN
cord-326257-rcv8sh22	147	8	APOBEC3	APOBEC3	NNP
cord-326257-rcv8sh22	147	9	G	g	NN
cord-326257-rcv8sh22	147	10	in	in	IN
cord-326257-rcv8sh22	147	11	natural	natural	JJ
cord-326257-rcv8sh22	147	12	killer	killer	NN
cord-326257-rcv8sh22	147	13	cells	cell	NNS
cord-326257-rcv8sh22	148	1	The	the	DT
cord-326257-rcv8sh22	148	2	double	double	JJ
cord-326257-rcv8sh22	148	3	-	-	HYPH
cord-326257-rcv8sh22	148	4	domain	domain	NN
cord-326257-rcv8sh22	148	5	cytidine	cytidine	NN
cord-326257-rcv8sh22	148	6	deaminase	deaminase	NN
cord-326257-rcv8sh22	148	7	395	395	CD
cord-326257-rcv8sh22	148	8	APOBEC3	APOBEC3	NNP
cord-326257-rcv8sh22	148	9	G	g	NN
cord-326257-rcv8sh22	148	10	is	be	VBZ
cord-326257-rcv8sh22	148	11	a	a	DT
cord-326257-rcv8sh22	148	12	cellular	cellular	JJ
cord-326257-rcv8sh22	148	13	site	site	NN
cord-326257-rcv8sh22	148	14	-	-	HYPH
cord-326257-rcv8sh22	148	15	specific	specific	JJ
cord-326257-rcv8sh22	148	16	RNA	RNA	NNP
cord-326257-rcv8sh22	148	17	editing	editing	NN
cord-326257-rcv8sh22	148	18	enzyme	enzyme	NN
cord-326257-rcv8sh22	148	19	Deamination	Deamination	NNP
cord-326257-rcv8sh22	148	20	hotspots	hotspot	NNS
cord-326257-rcv8sh22	148	21	among	among	IN
cord-326257-rcv8sh22	148	22	APOBEC3	apobec3	DT
cord-326257-rcv8sh22	148	23	family	family	NN
cord-326257-rcv8sh22	148	24	members	member	NNS
cord-326257-rcv8sh22	148	25	are	be	VBP
cord-326257-rcv8sh22	148	26	defined	define	VBN
cord-326257-rcv8sh22	148	27	by	by	IN
cord-326257-rcv8sh22	148	28	both	both	DT
cord-326257-rcv8sh22	148	29	target	target	NN
cord-326257-rcv8sh22	148	30	site	site	NN
cord-326257-rcv8sh22	148	31	sequence	sequence	NN
cord-326257-rcv8sh22	148	32	context	context	NN
cord-326257-rcv8sh22	148	33	and	and	CC
cord-326257-rcv8sh22	148	34	ssDNA	ssdna	JJ
cord-326257-rcv8sh22	148	35	secondary	secondary	JJ
cord-326257-rcv8sh22	148	36	structure	structure	NN
cord-326257-rcv8sh22	148	37	Cytosine	Cytosine	NNP
cord-326257-rcv8sh22	148	38	deamination	deamination	NN
cord-326257-rcv8sh22	148	39	and	and	CC
cord-326257-rcv8sh22	148	40	selection	selection	NN
cord-326257-rcv8sh22	148	41	of	of	IN
cord-326257-rcv8sh22	148	42	CpG	CpG	NNP
cord-326257-rcv8sh22	148	43	suppressed	suppress	VBD
cord-326257-rcv8sh22	148	44	clones	clone	NNS
cord-326257-rcv8sh22	148	45	are	be	VBP
cord-326257-rcv8sh22	148	46	the	the	DT
cord-326257-rcv8sh22	148	47	two	two	CD
cord-326257-rcv8sh22	148	48	major	major	JJ
cord-326257-rcv8sh22	148	49	independent	independent	JJ
cord-326257-rcv8sh22	148	50	biological	biological	JJ
cord-326257-rcv8sh22	148	51	forces	force	NNS
cord-326257-rcv8sh22	148	52	that	that	WDT
cord-326257-rcv8sh22	148	53	shape	shape	VBP
cord-326257-rcv8sh22	148	54	codon	codon	NN
cord-326257-rcv8sh22	148	55	usage	usage	NN
cord-326257-rcv8sh22	148	56	bias	bias	NN
cord-326257-rcv8sh22	148	57	in	in	IN
cord-326257-rcv8sh22	148	58	coronaviruses	coronaviruse	NNS
cord-326257-rcv8sh22	149	1	On	on	IN
cord-326257-rcv8sh22	149	2	the	the	DT
cord-326257-rcv8sh22	149	3	biased	biased	JJ
cord-326257-rcv8sh22	149	4	nucleotide	nucleotide	JJ
cord-326257-rcv8sh22	149	5	composition	composition	NN
cord-326257-rcv8sh22	149	6	of	of	IN
cord-326257-rcv8sh22	149	7	the	the	DT
cord-326257-rcv8sh22	149	8	human	human	JJ
cord-326257-rcv8sh22	149	9	coronavirus	coronavirus	NN
cord-326257-rcv8sh22	149	10	RNA	RNA	NNP
cord-326257-rcv8sh22	149	11	genome	genome	NN
cord-326257-rcv8sh22	149	12	Antiviral	antiviral	JJ
cord-326257-rcv8sh22	149	13	immune	immune	JJ
cord-326257-rcv8sh22	149	14	responses	response	NNS
cord-326257-rcv8sh22	149	15	of	of	IN
cord-326257-rcv8sh22	149	16	bats	bat	NNS
cord-326257-rcv8sh22	149	17	:	:	:
cord-326257-rcv8sh22	149	18	a	a	DT
cord-326257-rcv8sh22	149	19	review	review	NN
cord-326257-rcv8sh22	149	20	Hosts	Hosts	NNPS
cord-326257-rcv8sh22	149	21	and	and	CC
cord-326257-rcv8sh22	149	22	Sources	Sources	NNPS
cord-326257-rcv8sh22	149	23	of	of	IN
cord-326257-rcv8sh22	149	24	Endemic	Endemic	NNP
cord-326257-rcv8sh22	149	25	Human	Human	NNP
cord-326257-rcv8sh22	149	26	Coronaviruses	Coronaviruses	NNP
cord-326257-rcv8sh22	149	27	SSE	SSE	NNP
cord-326257-rcv8sh22	149	28	:	:	:
cord-326257-rcv8sh22	149	29	a	a	DT
cord-326257-rcv8sh22	149	30	nucleotide	nucleotide	JJ
cord-326257-rcv8sh22	149	31	and	and	CC
cord-326257-rcv8sh22	149	32	amino	amino	NN
cord-326257-rcv8sh22	149	33	acid	acid	NN
cord-326257-rcv8sh22	149	34	sequence	sequence	NN
cord-326257-rcv8sh22	149	35	analysis	analysis	NN
cord-326257-rcv8sh22	149	36	platform	platform	NN
cord-326257-rcv8sh22	149	37	MEGA6	MEGA6	NNP
cord-326257-rcv8sh22	149	38	:	:	:
cord-326257-rcv8sh22	150	1	Molecular	Molecular	NNP
cord-326257-rcv8sh22	150	2	Evolutionary	Evolutionary	NNP
cord-326257-rcv8sh22	150	3	Genetics	Genetics	NNP
cord-326257-rcv8sh22	150	4	Analysis	Analysis	NNP
cord-326257-rcv8sh22	150	5	version	version	NN
cord-326257-rcv8sh22	150	6	6.0	6.0	CD
cord-326257-rcv8sh22	151	1	The	the	DT
cord-326257-rcv8sh22	151	2	work	work	NN
cord-326257-rcv8sh22	151	3	was	be	VBD
cord-326257-rcv8sh22	151	4	supported	support	VBN
cord-326257-rcv8sh22	151	5	by	by	IN
cord-326257-rcv8sh22	151	6	a	a	DT
cord-326257-rcv8sh22	151	7	Wellcome	Wellcome	NNP
cord-326257-rcv8sh22	151	8	Investigator	Investigator	NNP
cord-326257-rcv8sh22	151	9	Award	Award	NNP
cord-326257-rcv8sh22	151	10	Grant	Grant	NNP
cord-326257-rcv8sh22	151	11	WT103767MA	WT103767MA	NNP
cord-326257-rcv8sh22	151	12	.	.	.