id sid tid token lemma pos cord-320054-wqpr8v3p 1 1 key key NN cord-320054-wqpr8v3p 1 2 : : : cord-320054-wqpr8v3p 2 1 cord-320054-wqpr8v3p cord-320054-wqpr8v3p CD cord-320054-wqpr8v3p 2 2 authors author NNS cord-320054-wqpr8v3p 2 3 : : : cord-320054-wqpr8v3p 2 4 Yuan Yuan NNP cord-320054-wqpr8v3p 2 5 , , , cord-320054-wqpr8v3p 2 6 Xianlin Xianlin NNP cord-320054-wqpr8v3p 2 7 ; ; : cord-320054-wqpr8v3p 2 8 li li NNP cord-320054-wqpr8v3p 2 9 , , , cord-320054-wqpr8v3p 2 10 liangping liangping NNP cord-320054-wqpr8v3p 2 11 title title NN cord-320054-wqpr8v3p 2 12 : : : cord-320054-wqpr8v3p 2 13 The the DT cord-320054-wqpr8v3p 2 14 influence influence NN cord-320054-wqpr8v3p 2 15 of of IN cord-320054-wqpr8v3p 2 16 major major JJ cord-320054-wqpr8v3p 2 17 S S NNP cord-320054-wqpr8v3p 2 18 protein protein NN cord-320054-wqpr8v3p 2 19 mutations mutation NNS cord-320054-wqpr8v3p 2 20 of of IN cord-320054-wqpr8v3p 2 21 SARS SARS NNP cord-320054-wqpr8v3p 2 22 - - HYPH cord-320054-wqpr8v3p 2 23 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 2 24 on on IN cord-320054-wqpr8v3p 2 25 the the DT cord-320054-wqpr8v3p 2 26 potential potential JJ cord-320054-wqpr8v3p 2 27 B b NN cord-320054-wqpr8v3p 2 28 cell cell NN cord-320054-wqpr8v3p 2 29 epitopes epitope NNS cord-320054-wqpr8v3p 2 30 date date NN cord-320054-wqpr8v3p 3 1 : : : cord-320054-wqpr8v3p 3 2 2020 2020 CD cord-320054-wqpr8v3p 3 3 - - HYPH cord-320054-wqpr8v3p 3 4 08 08 CD cord-320054-wqpr8v3p 3 5 - - HYPH cord-320054-wqpr8v3p 3 6 24 24 CD cord-320054-wqpr8v3p 3 7 journal journal NN cord-320054-wqpr8v3p 3 8 : : : cord-320054-wqpr8v3p 4 1 bioRxiv biorxiv IN cord-320054-wqpr8v3p 4 2 DOI DOI NNP cord-320054-wqpr8v3p 4 3 : : : cord-320054-wqpr8v3p 5 1 10.1101/2020.08.24.264895 10.1101/2020.08.24.264895 LS cord-320054-wqpr8v3p 6 1 sha sha NNP cord-320054-wqpr8v3p 6 2 : : : cord-320054-wqpr8v3p 6 3 2671fc4099d4405f84f5d30907d4f3f11c76a9e0 2671fc4099d4405f84f5d30907d4f3f11c76a9e0 CD cord-320054-wqpr8v3p 6 4 doc_id doc_id CD cord-320054-wqpr8v3p 6 5 : : : cord-320054-wqpr8v3p 6 6 320054 320054 CD cord-320054-wqpr8v3p 6 7 cord_uid cord_uid NNS cord-320054-wqpr8v3p 6 8 : : : cord-320054-wqpr8v3p 6 9 wqpr8v3p wqpr8v3p NNP cord-320054-wqpr8v3p 6 10 SARS SARS NNP cord-320054-wqpr8v3p 6 11 - - HYPH cord-320054-wqpr8v3p 6 12 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 6 13 has have VBZ cord-320054-wqpr8v3p 6 14 rapidly rapidly RB cord-320054-wqpr8v3p 6 15 transmitted transmit VBN cord-320054-wqpr8v3p 6 16 worldwide worldwide RB cord-320054-wqpr8v3p 6 17 and and CC cord-320054-wqpr8v3p 6 18 results result NNS cord-320054-wqpr8v3p 6 19 in in IN cord-320054-wqpr8v3p 6 20 the the DT cord-320054-wqpr8v3p 6 21 COVID-19 covid-19 JJ cord-320054-wqpr8v3p 6 22 pandemic pandemic NN cord-320054-wqpr8v3p 6 23 . . . cord-320054-wqpr8v3p 7 1 Spike spike NN cord-320054-wqpr8v3p 7 2 glycoprotein glycoprotein NN cord-320054-wqpr8v3p 7 3 on on IN cord-320054-wqpr8v3p 7 4 surface surface NN cord-320054-wqpr8v3p 7 5 is be VBZ cord-320054-wqpr8v3p 7 6 a a DT cord-320054-wqpr8v3p 7 7 key key JJ cord-320054-wqpr8v3p 7 8 factor factor NN cord-320054-wqpr8v3p 7 9 of of IN cord-320054-wqpr8v3p 7 10 viral viral JJ cord-320054-wqpr8v3p 7 11 transmission transmission NN cord-320054-wqpr8v3p 7 12 , , , cord-320054-wqpr8v3p 7 13 and and CC cord-320054-wqpr8v3p 7 14 has have VBZ cord-320054-wqpr8v3p 7 15 appeared appear VBN cord-320054-wqpr8v3p 7 16 a a DT cord-320054-wqpr8v3p 7 17 lot lot NN cord-320054-wqpr8v3p 7 18 of of IN cord-320054-wqpr8v3p 7 19 variants variant NNS cord-320054-wqpr8v3p 7 20 due due JJ cord-320054-wqpr8v3p 7 21 to to IN cord-320054-wqpr8v3p 7 22 gene gene NN cord-320054-wqpr8v3p 7 23 mutations mutation NNS cord-320054-wqpr8v3p 7 24 , , , cord-320054-wqpr8v3p 7 25 which which WDT cord-320054-wqpr8v3p 7 26 may may MD cord-320054-wqpr8v3p 7 27 influence influence VB cord-320054-wqpr8v3p 7 28 the the DT cord-320054-wqpr8v3p 7 29 viral viral JJ cord-320054-wqpr8v3p 7 30 antigenicity antigenicity NN cord-320054-wqpr8v3p 7 31 and and CC cord-320054-wqpr8v3p 7 32 vaccine vaccine NN cord-320054-wqpr8v3p 7 33 efficacy efficacy NN cord-320054-wqpr8v3p 7 34 . . . cord-320054-wqpr8v3p 8 1 Here here RB cord-320054-wqpr8v3p 8 2 , , , cord-320054-wqpr8v3p 8 3 we -PRON- PRP cord-320054-wqpr8v3p 8 4 used use VBD cord-320054-wqpr8v3p 8 5 bioinformatic bioinformatic JJ cord-320054-wqpr8v3p 8 6 tools tool NNS cord-320054-wqpr8v3p 8 7 to to TO cord-320054-wqpr8v3p 8 8 analyze analyze VB cord-320054-wqpr8v3p 8 9 B b NN cord-320054-wqpr8v3p 8 10 - - HYPH cord-320054-wqpr8v3p 8 11 cell cell NN cord-320054-wqpr8v3p 8 12 epitopes epitope NNS cord-320054-wqpr8v3p 8 13 of of IN cord-320054-wqpr8v3p 8 14 prototype prototype NN cord-320054-wqpr8v3p 8 15 S s NN cord-320054-wqpr8v3p 8 16 protein protein NN cord-320054-wqpr8v3p 8 17 and and CC cord-320054-wqpr8v3p 8 18 its -PRON- PRP$ cord-320054-wqpr8v3p 8 19 9 9 CD cord-320054-wqpr8v3p 8 20 common common JJ cord-320054-wqpr8v3p 8 21 variants variant NNS cord-320054-wqpr8v3p 8 22 . . . cord-320054-wqpr8v3p 9 1 12 12 CD cord-320054-wqpr8v3p 9 2 potential potential JJ cord-320054-wqpr8v3p 9 3 linear linear NN cord-320054-wqpr8v3p 9 4 and and CC cord-320054-wqpr8v3p 9 5 53 53 CD cord-320054-wqpr8v3p 9 6 discontinuous discontinuous JJ cord-320054-wqpr8v3p 9 7 epitopes epitope NNS cord-320054-wqpr8v3p 9 8 of of IN cord-320054-wqpr8v3p 9 9 B b NN cord-320054-wqpr8v3p 9 10 - - HYPH cord-320054-wqpr8v3p 9 11 cells cell NNS cord-320054-wqpr8v3p 9 12 were be VBD cord-320054-wqpr8v3p 9 13 predicted predict VBN cord-320054-wqpr8v3p 9 14 from from IN cord-320054-wqpr8v3p 9 15 the the DT cord-320054-wqpr8v3p 9 16 S S NNP cord-320054-wqpr8v3p 9 17 protein protein NN cord-320054-wqpr8v3p 9 18 prototype prototype NN cord-320054-wqpr8v3p 9 19 . . . cord-320054-wqpr8v3p 10 1 Importantly importantly RB cord-320054-wqpr8v3p 10 2 , , , cord-320054-wqpr8v3p 10 3 by by IN cord-320054-wqpr8v3p 10 4 comparing compare VBG cord-320054-wqpr8v3p 10 5 the the DT cord-320054-wqpr8v3p 10 6 epitope epitope NN cord-320054-wqpr8v3p 10 7 alterations alteration NNS cord-320054-wqpr8v3p 10 8 between between IN cord-320054-wqpr8v3p 10 9 prototype prototype NN cord-320054-wqpr8v3p 10 10 and and CC cord-320054-wqpr8v3p 10 11 variants variant NNS cord-320054-wqpr8v3p 10 12 , , , cord-320054-wqpr8v3p 10 13 we -PRON- PRP cord-320054-wqpr8v3p 10 14 demonstrate demonstrate VBP cord-320054-wqpr8v3p 10 15 that that DT cord-320054-wqpr8v3p 10 16 B b NN cord-320054-wqpr8v3p 10 17 - - HYPH cord-320054-wqpr8v3p 10 18 cell cell NN cord-320054-wqpr8v3p 10 19 epitopes epitope NNS cord-320054-wqpr8v3p 10 20 and and CC cord-320054-wqpr8v3p 10 21 antigenicity antigenicity NN cord-320054-wqpr8v3p 10 22 of of IN cord-320054-wqpr8v3p 10 23 9 9 CD cord-320054-wqpr8v3p 10 24 variants variant NNS cord-320054-wqpr8v3p 10 25 appear appear VBP cord-320054-wqpr8v3p 10 26 significantly significantly RB cord-320054-wqpr8v3p 10 27 different different JJ cord-320054-wqpr8v3p 10 28 alterations alteration NNS cord-320054-wqpr8v3p 10 29 . . . cord-320054-wqpr8v3p 11 1 The the DT cord-320054-wqpr8v3p 11 2 dominant dominant JJ cord-320054-wqpr8v3p 11 3 D614 d614 NN cord-320054-wqpr8v3p 11 4 G g NN cord-320054-wqpr8v3p 11 5 variant variant NN cord-320054-wqpr8v3p 11 6 impacts impact VBZ cord-320054-wqpr8v3p 11 7 the the DT cord-320054-wqpr8v3p 11 8 potential potential JJ cord-320054-wqpr8v3p 11 9 epitope epitope NN cord-320054-wqpr8v3p 11 10 least least JJS cord-320054-wqpr8v3p 11 11 , , , cord-320054-wqpr8v3p 11 12 only only RB cord-320054-wqpr8v3p 11 13 with with IN cord-320054-wqpr8v3p 11 14 moderately moderately RB cord-320054-wqpr8v3p 11 15 elevated elevated JJ cord-320054-wqpr8v3p 11 16 antigenicity antigenicity NN cord-320054-wqpr8v3p 11 17 , , , cord-320054-wqpr8v3p 11 18 while while IN cord-320054-wqpr8v3p 11 19 the the DT cord-320054-wqpr8v3p 11 20 epitopes epitope NNS cord-320054-wqpr8v3p 11 21 and and CC cord-320054-wqpr8v3p 11 22 antigenicity antigenicity NN cord-320054-wqpr8v3p 11 23 of of IN cord-320054-wqpr8v3p 11 24 some some DT cord-320054-wqpr8v3p 11 25 mutants(V483A mutants(v483a NN cord-320054-wqpr8v3p 11 26 , , , cord-320054-wqpr8v3p 11 27 V367F V367F NNP cord-320054-wqpr8v3p 11 28 , , , cord-320054-wqpr8v3p 11 29 etc etc FW cord-320054-wqpr8v3p 11 30 . . . cord-320054-wqpr8v3p 11 31 ) ) -RRB- cord-320054-wqpr8v3p 12 1 with with IN cord-320054-wqpr8v3p 12 2 small small JJ cord-320054-wqpr8v3p 12 3 incidence incidence NN cord-320054-wqpr8v3p 12 4 in in IN cord-320054-wqpr8v3p 12 5 the the DT cord-320054-wqpr8v3p 12 6 population population NN cord-320054-wqpr8v3p 12 7 change change NN cord-320054-wqpr8v3p 12 8 greatly greatly RB cord-320054-wqpr8v3p 12 9 . . . cord-320054-wqpr8v3p 13 1 These these DT cord-320054-wqpr8v3p 13 2 results result NNS cord-320054-wqpr8v3p 13 3 suggest suggest VBP cord-320054-wqpr8v3p 13 4 that that IN cord-320054-wqpr8v3p 13 5 the the DT cord-320054-wqpr8v3p 13 6 currently currently RB cord-320054-wqpr8v3p 13 7 developed develop VBN cord-320054-wqpr8v3p 13 8 vaccines vaccine NNS cord-320054-wqpr8v3p 13 9 should should MD cord-320054-wqpr8v3p 13 10 be be VB cord-320054-wqpr8v3p 13 11 valid valid JJ cord-320054-wqpr8v3p 13 12 for for IN cord-320054-wqpr8v3p 13 13 a a DT cord-320054-wqpr8v3p 13 14 majority majority NN cord-320054-wqpr8v3p 13 15 of of IN cord-320054-wqpr8v3p 13 16 SARS SARS NNP cord-320054-wqpr8v3p 13 17 - - HYPH cord-320054-wqpr8v3p 13 18 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 13 19 infectors infector NNS cord-320054-wqpr8v3p 13 20 . . . cord-320054-wqpr8v3p 14 1 This this DT cord-320054-wqpr8v3p 14 2 study study NN cord-320054-wqpr8v3p 14 3 provides provide VBZ cord-320054-wqpr8v3p 14 4 a a DT cord-320054-wqpr8v3p 14 5 scientific scientific JJ cord-320054-wqpr8v3p 14 6 basis basis NN cord-320054-wqpr8v3p 14 7 for for IN cord-320054-wqpr8v3p 14 8 large large JJ cord-320054-wqpr8v3p 14 9 - - HYPH cord-320054-wqpr8v3p 14 10 scale scale NN cord-320054-wqpr8v3p 14 11 application application NN cord-320054-wqpr8v3p 14 12 of of IN cord-320054-wqpr8v3p 14 13 SARS SARS NNP cord-320054-wqpr8v3p 14 14 - - HYPH cord-320054-wqpr8v3p 14 15 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 14 16 vaccines vaccine NNS cord-320054-wqpr8v3p 14 17 and and CC cord-320054-wqpr8v3p 14 18 for for IN cord-320054-wqpr8v3p 14 19 taking take VBG cord-320054-wqpr8v3p 14 20 precautions precaution NNS cord-320054-wqpr8v3p 14 21 against against IN cord-320054-wqpr8v3p 14 22 the the DT cord-320054-wqpr8v3p 14 23 probable probable JJ cord-320054-wqpr8v3p 14 24 appearance appearance NN cord-320054-wqpr8v3p 14 25 of of IN cord-320054-wqpr8v3p 14 26 antigen antigen NN cord-320054-wqpr8v3p 14 27 escape escape NN cord-320054-wqpr8v3p 14 28 induced induce VBN cord-320054-wqpr8v3p 14 29 by by IN cord-320054-wqpr8v3p 14 30 genetic genetic JJ cord-320054-wqpr8v3p 14 31 variation variation NN cord-320054-wqpr8v3p 14 32 after after IN cord-320054-wqpr8v3p 14 33 vaccination vaccination NN cord-320054-wqpr8v3p 14 34 . . . cord-320054-wqpr8v3p 15 1 Author Author NNP cord-320054-wqpr8v3p 15 2 Summary Summary NNP cord-320054-wqpr8v3p 16 1 The the DT cord-320054-wqpr8v3p 16 2 global global JJ cord-320054-wqpr8v3p 16 3 pandemic pandemic NN cord-320054-wqpr8v3p 16 4 of of IN cord-320054-wqpr8v3p 16 5 SARS SARS NNP cord-320054-wqpr8v3p 16 6 - - HYPH cord-320054-wqpr8v3p 16 7 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 16 8 has have VBZ cord-320054-wqpr8v3p 16 9 lasted last VBN cord-320054-wqpr8v3p 16 10 for for IN cord-320054-wqpr8v3p 16 11 more more JJR cord-320054-wqpr8v3p 16 12 than than IN cord-320054-wqpr8v3p 16 13 half half PDT cord-320054-wqpr8v3p 16 14 a a DT cord-320054-wqpr8v3p 16 15 year year NN cord-320054-wqpr8v3p 16 16 and and CC cord-320054-wqpr8v3p 16 17 has have VBZ cord-320054-wqpr8v3p 16 18 not not RB cord-320054-wqpr8v3p 16 19 yet yet RB cord-320054-wqpr8v3p 16 20 been be VBN cord-320054-wqpr8v3p 16 21 contained contain VBN cord-320054-wqpr8v3p 16 22 . . . cord-320054-wqpr8v3p 17 1 Until until IN cord-320054-wqpr8v3p 17 2 now now RB cord-320054-wqpr8v3p 17 3 there there EX cord-320054-wqpr8v3p 17 4 is be VBZ cord-320054-wqpr8v3p 17 5 no no DT cord-320054-wqpr8v3p 17 6 effective effective JJ cord-320054-wqpr8v3p 17 7 treatment treatment NN cord-320054-wqpr8v3p 17 8 for for IN cord-320054-wqpr8v3p 17 9 SARS SARS NNP cord-320054-wqpr8v3p 17 10 - - HYPH cord-320054-wqpr8v3p 17 11 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 17 12 caused cause VBD cord-320054-wqpr8v3p 17 13 disease disease NN cord-320054-wqpr8v3p 17 14 ( ( -LRB- cord-320054-wqpr8v3p 17 15 COVID-19 COVID-19 NNP cord-320054-wqpr8v3p 17 16 ) ) -RRB- cord-320054-wqpr8v3p 17 17 . . . cord-320054-wqpr8v3p 18 1 Successful successful JJ cord-320054-wqpr8v3p 18 2 vaccine vaccine NN cord-320054-wqpr8v3p 18 3 development development NN cord-320054-wqpr8v3p 18 4 seems seem VBZ cord-320054-wqpr8v3p 18 5 to to TO cord-320054-wqpr8v3p 18 6 be be VB cord-320054-wqpr8v3p 18 7 the the DT cord-320054-wqpr8v3p 18 8 only only JJ cord-320054-wqpr8v3p 18 9 hope hope NN cord-320054-wqpr8v3p 18 10 . . . cord-320054-wqpr8v3p 19 1 However however RB cord-320054-wqpr8v3p 19 2 , , , cord-320054-wqpr8v3p 19 3 this this DT cord-320054-wqpr8v3p 19 4 novel novel JJ cord-320054-wqpr8v3p 19 5 coronavirus coronavirus NN cord-320054-wqpr8v3p 19 6 belongs belong VBZ cord-320054-wqpr8v3p 19 7 to to IN cord-320054-wqpr8v3p 19 8 the the DT cord-320054-wqpr8v3p 19 9 RNA RNA NNP cord-320054-wqpr8v3p 19 10 virus virus NN cord-320054-wqpr8v3p 19 11 , , , cord-320054-wqpr8v3p 19 12 there there EX cord-320054-wqpr8v3p 19 13 is be VBZ cord-320054-wqpr8v3p 19 14 a a DT cord-320054-wqpr8v3p 19 15 high high JJ cord-320054-wqpr8v3p 19 16 mutation mutation NN cord-320054-wqpr8v3p 19 17 rate rate NN cord-320054-wqpr8v3p 19 18 in in IN cord-320054-wqpr8v3p 19 19 the the DT cord-320054-wqpr8v3p 19 20 genome genome NN cord-320054-wqpr8v3p 19 21 , , , cord-320054-wqpr8v3p 19 22 and and CC cord-320054-wqpr8v3p 19 23 these these DT cord-320054-wqpr8v3p 19 24 mutations mutation NNS cord-320054-wqpr8v3p 19 25 often often RB cord-320054-wqpr8v3p 19 26 locate locate VBP cord-320054-wqpr8v3p 19 27 on on IN cord-320054-wqpr8v3p 19 28 the the DT cord-320054-wqpr8v3p 19 29 Spike spike NN cord-320054-wqpr8v3p 19 30 proteins protein NNS cord-320054-wqpr8v3p 19 31 of of IN cord-320054-wqpr8v3p 19 32 virus virus NN cord-320054-wqpr8v3p 19 33 , , , cord-320054-wqpr8v3p 19 34 the the DT cord-320054-wqpr8v3p 19 35 gripper gripper NN cord-320054-wqpr8v3p 19 36 of of IN cord-320054-wqpr8v3p 19 37 the the DT cord-320054-wqpr8v3p 19 38 virus virus NN cord-320054-wqpr8v3p 19 39 entering enter VBG cord-320054-wqpr8v3p 19 40 the the DT cord-320054-wqpr8v3p 19 41 cells cell NNS cord-320054-wqpr8v3p 19 42 . . . cord-320054-wqpr8v3p 20 1 Vaccination vaccination NN cord-320054-wqpr8v3p 20 2 induce induce VBP cord-320054-wqpr8v3p 20 3 the the DT cord-320054-wqpr8v3p 20 4 generation generation NN cord-320054-wqpr8v3p 20 5 of of IN cord-320054-wqpr8v3p 20 6 antibodies antibody NNS cord-320054-wqpr8v3p 20 7 , , , cord-320054-wqpr8v3p 20 8 which which WDT cord-320054-wqpr8v3p 20 9 block block VBP cord-320054-wqpr8v3p 20 10 Spike Spike NNP cord-320054-wqpr8v3p 20 11 protein protein NN cord-320054-wqpr8v3p 20 12 . . . cord-320054-wqpr8v3p 21 1 However however RB cord-320054-wqpr8v3p 21 2 , , , cord-320054-wqpr8v3p 21 3 the the DT cord-320054-wqpr8v3p 21 4 Spike Spike NNP cord-320054-wqpr8v3p 21 5 protein protein NN cord-320054-wqpr8v3p 21 6 variants variant NNS cord-320054-wqpr8v3p 21 7 may may MD cord-320054-wqpr8v3p 21 8 change change VB cord-320054-wqpr8v3p 21 9 the the DT cord-320054-wqpr8v3p 21 10 recognition recognition NN cord-320054-wqpr8v3p 21 11 and and CC cord-320054-wqpr8v3p 21 12 binding binding NN cord-320054-wqpr8v3p 21 13 of of IN cord-320054-wqpr8v3p 21 14 antibodies antibody NNS cord-320054-wqpr8v3p 21 15 and and CC cord-320054-wqpr8v3p 21 16 make make VB cord-320054-wqpr8v3p 21 17 the the DT cord-320054-wqpr8v3p 21 18 vaccine vaccine NN cord-320054-wqpr8v3p 21 19 ineffective ineffective JJ cord-320054-wqpr8v3p 21 20 . . . cord-320054-wqpr8v3p 22 1 In in IN cord-320054-wqpr8v3p 22 2 this this DT cord-320054-wqpr8v3p 22 3 study study NN cord-320054-wqpr8v3p 22 4 , , , cord-320054-wqpr8v3p 22 5 we -PRON- PRP cord-320054-wqpr8v3p 22 6 predict predict VBP cord-320054-wqpr8v3p 22 7 neutralizing neutralize VBG cord-320054-wqpr8v3p 22 8 antibody antibody NN cord-320054-wqpr8v3p 22 9 recognition recognition NN cord-320054-wqpr8v3p 22 10 sites site NNS cord-320054-wqpr8v3p 22 11 ( ( -LRB- cord-320054-wqpr8v3p 22 12 B b NN cord-320054-wqpr8v3p 22 13 cell cell NN cord-320054-wqpr8v3p 22 14 epitopes epitope NNS cord-320054-wqpr8v3p 22 15 ) ) -RRB- cord-320054-wqpr8v3p 22 16 of of IN cord-320054-wqpr8v3p 22 17 the the DT cord-320054-wqpr8v3p 22 18 prototype prototype NN cord-320054-wqpr8v3p 22 19 S s NN cord-320054-wqpr8v3p 22 20 protein protein NN cord-320054-wqpr8v3p 22 21 of of IN cord-320054-wqpr8v3p 22 22 SARS SARS NNP cord-320054-wqpr8v3p 22 23 - - HYPH cord-320054-wqpr8v3p 22 24 COV2 COV2 NNP cord-320054-wqpr8v3p 22 25 , , , cord-320054-wqpr8v3p 22 26 along along IN cord-320054-wqpr8v3p 22 27 with with IN cord-320054-wqpr8v3p 22 28 several several JJ cord-320054-wqpr8v3p 22 29 common common JJ cord-320054-wqpr8v3p 22 30 variants variant NNS cord-320054-wqpr8v3p 22 31 using use VBG cord-320054-wqpr8v3p 22 32 bioinformatics bioinformatics NN cord-320054-wqpr8v3p 22 33 tools tool NNS cord-320054-wqpr8v3p 22 34 . . . cord-320054-wqpr8v3p 23 1 We -PRON- PRP cord-320054-wqpr8v3p 23 2 discovered discover VBD cord-320054-wqpr8v3p 23 3 the the DT cord-320054-wqpr8v3p 23 4 variability variability NN cord-320054-wqpr8v3p 23 5 in in IN cord-320054-wqpr8v3p 23 6 antigenicity antigenicity NN cord-320054-wqpr8v3p 23 7 among among IN cord-320054-wqpr8v3p 23 8 the the DT cord-320054-wqpr8v3p 23 9 mutants mutant NNS cord-320054-wqpr8v3p 23 10 , , , cord-320054-wqpr8v3p 23 11 for for IN cord-320054-wqpr8v3p 23 12 instance instance NN cord-320054-wqpr8v3p 23 13 , , , cord-320054-wqpr8v3p 23 14 in in IN cord-320054-wqpr8v3p 23 15 the the DT cord-320054-wqpr8v3p 23 16 more more RBR cord-320054-wqpr8v3p 23 17 widespread widespread JJ cord-320054-wqpr8v3p 23 18 D614 d614 NN cord-320054-wqpr8v3p 23 19 G g NN cord-320054-wqpr8v3p 23 20 variant variant NN cord-320054-wqpr8v3p 23 21 the the DT cord-320054-wqpr8v3p 23 22 change change NN cord-320054-wqpr8v3p 23 23 of of IN cord-320054-wqpr8v3p 23 24 epitope epitope NN cord-320054-wqpr8v3p 23 25 was be VBD cord-320054-wqpr8v3p 23 26 least least RBS cord-320054-wqpr8v3p 23 27 affected affect VBN cord-320054-wqpr8v3p 23 28 , , , cord-320054-wqpr8v3p 23 29 only only RB cord-320054-wqpr8v3p 23 30 with with IN cord-320054-wqpr8v3p 23 31 slight slight JJ cord-320054-wqpr8v3p 23 32 increase increase NN cord-320054-wqpr8v3p 23 33 of of IN cord-320054-wqpr8v3p 23 34 antigenicity antigenicity NN cord-320054-wqpr8v3p 23 35 . . . cord-320054-wqpr8v3p 24 1 However however RB cord-320054-wqpr8v3p 24 2 , , , cord-320054-wqpr8v3p 24 3 the the DT cord-320054-wqpr8v3p 24 4 antigenic antigenic JJ cord-320054-wqpr8v3p 24 5 epitopes epitope NNS cord-320054-wqpr8v3p 24 6 of of IN cord-320054-wqpr8v3p 24 7 some some DT cord-320054-wqpr8v3p 24 8 mutants mutant NNS cord-320054-wqpr8v3p 24 9 change change VBP cord-320054-wqpr8v3p 24 10 greatly greatly RB cord-320054-wqpr8v3p 24 11 . . . cord-320054-wqpr8v3p 25 1 These these DT cord-320054-wqpr8v3p 25 2 results result NNS cord-320054-wqpr8v3p 25 3 could could MD cord-320054-wqpr8v3p 25 4 be be VB cord-320054-wqpr8v3p 25 5 of of IN cord-320054-wqpr8v3p 25 6 potential potential JJ cord-320054-wqpr8v3p 25 7 importance importance NN cord-320054-wqpr8v3p 25 8 for for IN cord-320054-wqpr8v3p 25 9 future future JJ cord-320054-wqpr8v3p 25 10 vaccine vaccine NN cord-320054-wqpr8v3p 25 11 design design NN cord-320054-wqpr8v3p 25 12 and and CC cord-320054-wqpr8v3p 25 13 application application NN cord-320054-wqpr8v3p 25 14 against against IN cord-320054-wqpr8v3p 25 15 SARS SARS NNP cord-320054-wqpr8v3p 25 16 - - HYPH cord-320054-wqpr8v3p 25 17 CoV2 CoV2 NNP cord-320054-wqpr8v3p 25 18 variants variant NNS cord-320054-wqpr8v3p 25 19 . . . cord-320054-wqpr8v3p 26 1 Author Author NNP cord-320054-wqpr8v3p 26 2 Summary Summary NNP cord-320054-wqpr8v3p 26 3 24 24 CD cord-320054-wqpr8v3p 27 1 The the DT cord-320054-wqpr8v3p 27 2 global global JJ cord-320054-wqpr8v3p 27 3 pandemic pandemic NN cord-320054-wqpr8v3p 27 4 of of IN cord-320054-wqpr8v3p 27 5 SARS SARS NNP cord-320054-wqpr8v3p 27 6 - - HYPH cord-320054-wqpr8v3p 27 7 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 27 8 has have VBZ cord-320054-wqpr8v3p 27 9 lasted last VBN cord-320054-wqpr8v3p 27 10 for for IN cord-320054-wqpr8v3p 27 11 more more JJR cord-320054-wqpr8v3p 27 12 than than IN cord-320054-wqpr8v3p 27 13 half half PDT cord-320054-wqpr8v3p 27 14 a a DT cord-320054-wqpr8v3p 27 15 year year NN cord-320054-wqpr8v3p 27 16 and and CC cord-320054-wqpr8v3p 27 17 has have VBZ cord-320054-wqpr8v3p 27 18 25 25 CD cord-320054-wqpr8v3p 27 19 not not RB cord-320054-wqpr8v3p 27 20 yet yet RB cord-320054-wqpr8v3p 27 21 been be VBN cord-320054-wqpr8v3p 27 22 contained contain VBN cord-320054-wqpr8v3p 27 23 . . . cord-320054-wqpr8v3p 28 1 Until until IN cord-320054-wqpr8v3p 28 2 now now RB cord-320054-wqpr8v3p 28 3 there there EX cord-320054-wqpr8v3p 28 4 is be VBZ cord-320054-wqpr8v3p 28 5 no no DT cord-320054-wqpr8v3p 28 6 effective effective JJ cord-320054-wqpr8v3p 28 7 treatment treatment NN cord-320054-wqpr8v3p 28 8 for for IN cord-320054-wqpr8v3p 29 1 SARS SARS NNP cord-320054-wqpr8v3p 29 2 - - HYPH cord-320054-wqpr8v3p 29 3 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 29 4 26 26 CD cord-320054-wqpr8v3p 29 5 caused cause VBD cord-320054-wqpr8v3p 29 6 disease disease NN cord-320054-wqpr8v3p 29 7 . . . cord-320054-wqpr8v3p 30 1 Successful successful JJ cord-320054-wqpr8v3p 30 2 vaccine vaccine NN cord-320054-wqpr8v3p 30 3 development development NN cord-320054-wqpr8v3p 30 4 seems seem VBZ cord-320054-wqpr8v3p 30 5 to to TO cord-320054-wqpr8v3p 30 6 be be VB cord-320054-wqpr8v3p 30 7 the the DT cord-320054-wqpr8v3p 30 8 only only JJ cord-320054-wqpr8v3p 30 9 27 27 CD cord-320054-wqpr8v3p 30 10 hope hope NN cord-320054-wqpr8v3p 30 11 . . . cord-320054-wqpr8v3p 31 1 However however RB cord-320054-wqpr8v3p 31 2 , , , cord-320054-wqpr8v3p 31 3 this this DT cord-320054-wqpr8v3p 31 4 novel novel JJ cord-320054-wqpr8v3p 31 5 coronavirus coronavirus NN cord-320054-wqpr8v3p 31 6 belongs belong VBZ cord-320054-wqpr8v3p 31 7 to to IN cord-320054-wqpr8v3p 31 8 the the DT cord-320054-wqpr8v3p 31 9 RNA RNA NNP cord-320054-wqpr8v3p 31 10 virus virus NN cord-320054-wqpr8v3p 31 11 , , , cord-320054-wqpr8v3p 31 12 there there EX cord-320054-wqpr8v3p 31 13 is be VBZ cord-320054-wqpr8v3p 31 14 a a DT cord-320054-wqpr8v3p 31 15 high high JJ cord-320054-wqpr8v3p 31 16 28 28 CD cord-320054-wqpr8v3p 31 17 mutation mutation NN cord-320054-wqpr8v3p 31 18 rate rate NN cord-320054-wqpr8v3p 31 19 in in IN cord-320054-wqpr8v3p 31 20 the the DT cord-320054-wqpr8v3p 31 21 genome genome NN cord-320054-wqpr8v3p 31 22 , , , cord-320054-wqpr8v3p 31 23 and and CC cord-320054-wqpr8v3p 31 24 these these DT cord-320054-wqpr8v3p 31 25 mutations mutation NNS cord-320054-wqpr8v3p 31 26 often often RB cord-320054-wqpr8v3p 31 27 locate locate VBP cord-320054-wqpr8v3p 31 28 on on IN cord-320054-wqpr8v3p 31 29 the the DT cord-320054-wqpr8v3p 31 30 Spike spike NN cord-320054-wqpr8v3p 31 31 proteins protein NNS cord-320054-wqpr8v3p 31 32 of of IN cord-320054-wqpr8v3p 31 33 . . . cord-320054-wqpr8v3p 32 1 54 54 CD cord-320054-wqpr8v3p 33 1 Since since IN cord-320054-wqpr8v3p 33 2 January January NNP cord-320054-wqpr8v3p 33 3 30 30 CD cord-320054-wqpr8v3p 33 4 , , , cord-320054-wqpr8v3p 33 5 2020 2020 CD cord-320054-wqpr8v3p 33 6 , , , cord-320054-wqpr8v3p 33 7 the the DT cord-320054-wqpr8v3p 33 8 WHO who WP cord-320054-wqpr8v3p 33 9 announced announce VBD cord-320054-wqpr8v3p 33 10 the the DT cord-320054-wqpr8v3p 33 11 CoVID-19 CoVID-19 NNP cord-320054-wqpr8v3p 33 12 contagion contagion NN cord-320054-wqpr8v3p 33 13 as as IN cord-320054-wqpr8v3p 33 14 a a DT cord-320054-wqpr8v3p 33 15 public public JJ cord-320054-wqpr8v3p 33 16 55 55 CD cord-320054-wqpr8v3p 33 17 health health NN cord-320054-wqpr8v3p 33 18 emergency emergency NN cord-320054-wqpr8v3p 33 19 of of IN cord-320054-wqpr8v3p 33 20 global global JJ cord-320054-wqpr8v3p 33 21 concern concern NN cord-320054-wqpr8v3p 33 22 . . . cord-320054-wqpr8v3p 34 1 As as IN cord-320054-wqpr8v3p 34 2 of of IN cord-320054-wqpr8v3p 34 3 July July NNP cord-320054-wqpr8v3p 34 4 20 20 CD cord-320054-wqpr8v3p 34 5 , , , cord-320054-wqpr8v3p 34 6 14348858 14348858 CD cord-320054-wqpr8v3p 34 7 cases case NNS cord-320054-wqpr8v3p 34 8 of of IN cord-320054-wqpr8v3p 34 9 COVID-19 covid-19 CD cord-320054-wqpr8v3p 34 10 and and CC cord-320054-wqpr8v3p 34 11 4 4 CD cord-320054-wqpr8v3p 34 12 56 56 CD cord-320054-wqpr8v3p 34 13 603691 603691 CD cord-320054-wqpr8v3p 34 14 deaths death NNS cord-320054-wqpr8v3p 34 15 have have VBP cord-320054-wqpr8v3p 34 16 been be VBN cord-320054-wqpr8v3p 34 17 reported report VBN cord-320054-wqpr8v3p 34 18 globally globally RB cord-320054-wqpr8v3p 34 19 according accord VBG cord-320054-wqpr8v3p 34 20 to to IN cord-320054-wqpr8v3p 34 21 COVID-19 COVID-19 NNP cord-320054-wqpr8v3p 34 22 Situation Situation NNP cord-320054-wqpr8v3p 34 23 Report-182 Report-182 NNP cord-320054-wqpr8v3p 34 24 57 57 CD cord-320054-wqpr8v3p 34 25 ( ( -LRB- cord-320054-wqpr8v3p 34 26 WHO who WP cord-320054-wqpr8v3p 34 27 website website NN cord-320054-wqpr8v3p 34 28 at at IN cord-320054-wqpr8v3p 34 29 https://www.who.int/emergencies/diseases/ https://www.who.int/emergencies/diseases/ ADD cord-320054-wqpr8v3p 34 30 novel novel NN cord-320054-wqpr8v3p 34 31 - - : cord-320054-wqpr8v3p 34 32 coronavirus-2019 coronavirus-2019 NNP cord-320054-wqpr8v3p 34 33 ) ) -RRB- cord-320054-wqpr8v3p 34 34 . . . cord-320054-wqpr8v3p 35 1 58 58 CD cord-320054-wqpr8v3p 36 1 The the DT cord-320054-wqpr8v3p 36 2 virion virion NN cord-320054-wqpr8v3p 36 3 of of IN cord-320054-wqpr8v3p 36 4 SARS SARS NNP cord-320054-wqpr8v3p 36 5 - - HYPH cord-320054-wqpr8v3p 36 6 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 36 7 is be VBZ cord-320054-wqpr8v3p 36 8 spherical spherical JJ cord-320054-wqpr8v3p 36 9 , , , cord-320054-wqpr8v3p 36 10 enveloped envelop VBN cord-320054-wqpr8v3p 36 11 , , , cord-320054-wqpr8v3p 36 12 and and CC cord-320054-wqpr8v3p 36 13 60 60 CD cord-320054-wqpr8v3p 36 14 - - SYM cord-320054-wqpr8v3p 36 15 140 140 CD cord-320054-wqpr8v3p 36 16 nm nm NN cord-320054-wqpr8v3p 36 17 in in IN cord-320054-wqpr8v3p 36 18 diameter diameter NN cord-320054-wqpr8v3p 36 19 59 59 CD cord-320054-wqpr8v3p 36 20 with with IN cord-320054-wqpr8v3p 36 21 spikes spike NNS cord-320054-wqpr8v3p 36 22 of of IN cord-320054-wqpr8v3p 36 23 about about RB cord-320054-wqpr8v3p 36 24 9 9 CD cord-320054-wqpr8v3p 36 25 - - SYM cord-320054-wqpr8v3p 36 26 12 12 CD cord-320054-wqpr8v3p 36 27 nm nm NN cord-320054-wqpr8v3p 36 28 outside outside RB cord-320054-wqpr8v3p 36 29 . . . cord-320054-wqpr8v3p 37 1 The the DT cord-320054-wqpr8v3p 37 2 coronaviral coronaviral JJ cord-320054-wqpr8v3p 37 3 genome genome NN cord-320054-wqpr8v3p 37 4 encodes encode VBZ cord-320054-wqpr8v3p 37 5 10 10 CD cord-320054-wqpr8v3p 37 6 proteins protein NNS cord-320054-wqpr8v3p 37 7 , , , cord-320054-wqpr8v3p 37 8 60 60 CD cord-320054-wqpr8v3p 37 9 four four CD cord-320054-wqpr8v3p 37 10 of of IN cord-320054-wqpr8v3p 37 11 them -PRON- PRP cord-320054-wqpr8v3p 37 12 are be VBP cord-320054-wqpr8v3p 37 13 major major JJ cord-320054-wqpr8v3p 37 14 structural structural JJ cord-320054-wqpr8v3p 37 15 proteins protein NNS cord-320054-wqpr8v3p 37 16 : : : cord-320054-wqpr8v3p 37 17 the the DT cord-320054-wqpr8v3p 37 18 spike spike NN cord-320054-wqpr8v3p 37 19 ( ( -LRB- cord-320054-wqpr8v3p 37 20 S S NNP cord-320054-wqpr8v3p 37 21 ) ) -RRB- cord-320054-wqpr8v3p 37 22 , , , cord-320054-wqpr8v3p 37 23 membrane membrane NN cord-320054-wqpr8v3p 37 24 ( ( -LRB- cord-320054-wqpr8v3p 37 25 M M NNP cord-320054-wqpr8v3p 37 26 ) ) -RRB- cord-320054-wqpr8v3p 37 27 , , , cord-320054-wqpr8v3p 37 28 envelope envelope NN cord-320054-wqpr8v3p 37 29 ( ( -LRB- cord-320054-wqpr8v3p 37 30 E e NN cord-320054-wqpr8v3p 37 31 ) ) -RRB- cord-320054-wqpr8v3p 37 32 61 61 CD cord-320054-wqpr8v3p 37 33 and and CC cord-320054-wqpr8v3p 37 34 nucleocapsid nucleocapsid NN cord-320054-wqpr8v3p 37 35 ( ( -LRB- cord-320054-wqpr8v3p 37 36 N N NNP cord-320054-wqpr8v3p 37 37 ) ) -RRB- cord-320054-wqpr8v3p 37 38 proteins protein NNS cord-320054-wqpr8v3p 37 39 [ [ -LRB- cord-320054-wqpr8v3p 37 40 7 7 CD cord-320054-wqpr8v3p 37 41 ] ] -RRB- cord-320054-wqpr8v3p 37 42 . . . cord-320054-wqpr8v3p 38 1 Each each DT cord-320054-wqpr8v3p 38 2 of of IN cord-320054-wqpr8v3p 38 3 these these DT cord-320054-wqpr8v3p 38 4 proteins protein NNS cord-320054-wqpr8v3p 38 5 is be VBZ cord-320054-wqpr8v3p 38 6 responsible responsible JJ cord-320054-wqpr8v3p 38 7 for for IN cord-320054-wqpr8v3p 38 8 different different JJ cord-320054-wqpr8v3p 38 9 in in IN cord-320054-wqpr8v3p 38 10 the the DT cord-320054-wqpr8v3p 38 11 SARS SARS NNP cord-320054-wqpr8v3p 38 12 - - HYPH cord-320054-wqpr8v3p 38 13 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 38 14 genome genome NN cord-320054-wqpr8v3p 38 15 were be VBD cord-320054-wqpr8v3p 38 16 discovered discover VBN cord-320054-wqpr8v3p 38 17 from from IN cord-320054-wqpr8v3p 38 18 10022 10022 CD cord-320054-wqpr8v3p 38 19 public public JJ cord-320054-wqpr8v3p 38 20 genome genome NN cord-320054-wqpr8v3p 38 21 data datum NNS cord-320054-wqpr8v3p 38 22 81 81 CD cord-320054-wqpr8v3p 38 23 assemblies assembly NNS cord-320054-wqpr8v3p 38 24 as as IN cord-320054-wqpr8v3p 38 25 at at IN cord-320054-wqpr8v3p 38 26 May May NNP cord-320054-wqpr8v3p 38 27 1 1 CD cord-320054-wqpr8v3p 38 28 , , , cord-320054-wqpr8v3p 38 29 2020 2020 CD cord-320054-wqpr8v3p 38 30 [ [ -LRB- cord-320054-wqpr8v3p 38 31 9 9 CD cord-320054-wqpr8v3p 38 32 ] ] -RRB- cord-320054-wqpr8v3p 38 33 , , , cord-320054-wqpr8v3p 38 34 in in IN cord-320054-wqpr8v3p 38 35 which which WDT cord-320054-wqpr8v3p 38 36 394 394 CD cord-320054-wqpr8v3p 38 37 missense missense NN cord-320054-wqpr8v3p 38 38 mutations mutation NNS cord-320054-wqpr8v3p 38 39 of of IN cord-320054-wqpr8v3p 38 40 S s NN cord-320054-wqpr8v3p 38 41 protein protein NN cord-320054-wqpr8v3p 38 42 were be VBD cord-320054-wqpr8v3p 38 43 82 82 CD cord-320054-wqpr8v3p 38 44 detected detect VBN cord-320054-wqpr8v3p 38 45 . . . cord-320054-wqpr8v3p 39 1 Among among IN cord-320054-wqpr8v3p 39 2 these these DT cord-320054-wqpr8v3p 39 3 spike spike NN cord-320054-wqpr8v3p 39 4 mutations mutation NNS cord-320054-wqpr8v3p 39 5 , , , cord-320054-wqpr8v3p 39 6 D614 d614 NN cord-320054-wqpr8v3p 39 7 G g NN cord-320054-wqpr8v3p 39 8 mutation mutation NN cord-320054-wqpr8v3p 39 9 , , , cord-320054-wqpr8v3p 39 10 in in IN cord-320054-wqpr8v3p 39 11 which which WDT cord-320054-wqpr8v3p 39 12 Aspartic aspartic JJ cord-320054-wqpr8v3p 39 13 acid acid NN cord-320054-wqpr8v3p 39 14 ( ( -LRB- cord-320054-wqpr8v3p 39 15 D d NN cord-320054-wqpr8v3p 39 16 ) ) -RRB- cord-320054-wqpr8v3p 39 17 83 83 CD cord-320054-wqpr8v3p 39 18 was be VBD cord-320054-wqpr8v3p 39 19 replaced replace VBN cord-320054-wqpr8v3p 39 20 with with IN cord-320054-wqpr8v3p 39 21 Glycine glycine NN cord-320054-wqpr8v3p 39 22 ( ( -LRB- cord-320054-wqpr8v3p 39 23 G G NNP cord-320054-wqpr8v3p 39 24 ) ) -RRB- cord-320054-wqpr8v3p 39 25 at at IN cord-320054-wqpr8v3p 39 26 the the DT cord-320054-wqpr8v3p 39 27 AA AA NNP cord-320054-wqpr8v3p 39 28 site site NN cord-320054-wqpr8v3p 39 29 of of IN cord-320054-wqpr8v3p 39 30 614 614 CD cord-320054-wqpr8v3p 39 31 , , , cord-320054-wqpr8v3p 39 32 was be VBD cord-320054-wqpr8v3p 39 33 a a DT cord-320054-wqpr8v3p 39 34 major major JJ cord-320054-wqpr8v3p 39 35 mutation mutation NN cord-320054-wqpr8v3p 39 36 of of IN cord-320054-wqpr8v3p 39 37 great great JJ cord-320054-wqpr8v3p 39 38 84 84 CD cord-320054-wqpr8v3p 39 39 concern concern NN cord-320054-wqpr8v3p 39 40 [ [ -LRB- cord-320054-wqpr8v3p 39 41 10 10 CD cord-320054-wqpr8v3p 39 42 , , , cord-320054-wqpr8v3p 39 43 11 11 CD cord-320054-wqpr8v3p 39 44 ] ] -RRB- cord-320054-wqpr8v3p 39 45 . . . cord-320054-wqpr8v3p 40 1 SARS SARS NNP cord-320054-wqpr8v3p 40 2 - - HYPH cord-320054-wqpr8v3p 40 3 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 40 4 with with IN cord-320054-wqpr8v3p 40 5 D614 d614 NN cord-320054-wqpr8v3p 40 6 G g NN cord-320054-wqpr8v3p 40 7 mutation mutation NN cord-320054-wqpr8v3p 40 8 may may MD cord-320054-wqpr8v3p 40 9 have have VB cord-320054-wqpr8v3p 40 10 triggered trigger VBN cord-320054-wqpr8v3p 40 11 fatal fatal JJ cord-320054-wqpr8v3p 40 12 85 85 CD cord-320054-wqpr8v3p 40 13 infections infection NNS cord-320054-wqpr8v3p 40 14 in in IN cord-320054-wqpr8v3p 40 15 many many JJ cord-320054-wqpr8v3p 40 16 European european JJ cord-320054-wqpr8v3p 40 17 countries country NNS cord-320054-wqpr8v3p 40 18 , , , cord-320054-wqpr8v3p 40 19 such such JJ cord-320054-wqpr8v3p 40 20 as as IN cord-320054-wqpr8v3p 40 21 Spain Spain NNP cord-320054-wqpr8v3p 40 22 , , , cord-320054-wqpr8v3p 40 23 Italy Italy NNP cord-320054-wqpr8v3p 40 24 , , , cord-320054-wqpr8v3p 40 25 France France NNP cord-320054-wqpr8v3p 40 26 , , , cord-320054-wqpr8v3p 40 27 etc etc FW cord-320054-wqpr8v3p 40 28 . . . cord-320054-wqpr8v3p 41 1 [ [ -LRB- cord-320054-wqpr8v3p 41 2 11 11 CD cord-320054-wqpr8v3p 41 3 ] ] -RRB- cord-320054-wqpr8v3p 41 4 . . . cord-320054-wqpr8v3p 42 1 86 86 CD cord-320054-wqpr8v3p 43 1 These these DT cord-320054-wqpr8v3p 43 2 mutations mutation NNS cord-320054-wqpr8v3p 43 3 will will MD cord-320054-wqpr8v3p 43 4 undoubtedly undoubtedly RB cord-320054-wqpr8v3p 43 5 cause cause VB cord-320054-wqpr8v3p 43 6 changes change NNS cord-320054-wqpr8v3p 43 7 in in IN cord-320054-wqpr8v3p 43 8 the the DT cord-320054-wqpr8v3p 43 9 structure structure NN cord-320054-wqpr8v3p 43 10 of of IN cord-320054-wqpr8v3p 43 11 S s NN cord-320054-wqpr8v3p 43 12 proteins protein NNS cord-320054-wqpr8v3p 43 13 . . . cord-320054-wqpr8v3p 44 1 87 87 CD cord-320054-wqpr8v3p 45 1 However however RB cord-320054-wqpr8v3p 45 2 , , , cord-320054-wqpr8v3p 45 3 it -PRON- PRP cord-320054-wqpr8v3p 45 4 's be VBZ cord-320054-wqpr8v3p 45 5 highly highly RB cord-320054-wqpr8v3p 45 6 worth worth JJ cord-320054-wqpr8v3p 45 7 concerning concern VBG cord-320054-wqpr8v3p 45 8 whether whether IN cord-320054-wqpr8v3p 45 9 or or CC cord-320054-wqpr8v3p 45 10 not not RB cord-320054-wqpr8v3p 45 11 these these DT cord-320054-wqpr8v3p 45 12 mutations mutation NNS cord-320054-wqpr8v3p 45 13 affect affect VBP cord-320054-wqpr8v3p 45 14 the the DT cord-320054-wqpr8v3p 45 15 88 88 CD cord-320054-wqpr8v3p 45 16 antigenicity antigenicity NN cord-320054-wqpr8v3p 45 17 of of IN cord-320054-wqpr8v3p 45 18 S S NNP cord-320054-wqpr8v3p 45 19 proteins protein NNS cord-320054-wqpr8v3p 45 20 and and CC cord-320054-wqpr8v3p 45 21 the the DT cord-320054-wqpr8v3p 45 22 binding binding JJ cord-320054-wqpr8v3p 45 23 ability ability NN cord-320054-wqpr8v3p 45 24 with with IN cord-320054-wqpr8v3p 45 25 neutralizing neutralize VBG cord-320054-wqpr8v3p 45 26 antibodies antibody NNS cord-320054-wqpr8v3p 45 27 . . . cord-320054-wqpr8v3p 46 1 If if IN cord-320054-wqpr8v3p 46 2 the the DT cord-320054-wqpr8v3p 46 3 89 89 CD cord-320054-wqpr8v3p 46 4 B b NN cord-320054-wqpr8v3p 46 5 - - HYPH cord-320054-wqpr8v3p 46 6 cell cell NN cord-320054-wqpr8v3p 46 7 epitopes epitope NNS cord-320054-wqpr8v3p 46 8 on on IN cord-320054-wqpr8v3p 46 9 S S NNP cord-320054-wqpr8v3p 46 10 protein protein NN cord-320054-wqpr8v3p 46 11 changed change VBD cord-320054-wqpr8v3p 46 12 and and CC cord-320054-wqpr8v3p 46 13 could could MD cord-320054-wqpr8v3p 46 14 not not RB cord-320054-wqpr8v3p 46 15 bind bind VB cord-320054-wqpr8v3p 46 16 the the DT cord-320054-wqpr8v3p 46 17 neutralizing neutralize VBG cord-320054-wqpr8v3p 46 18 antibodies antibody NNS cord-320054-wqpr8v3p 46 19 , , , cord-320054-wqpr8v3p 46 20 it -PRON- PRP cord-320054-wqpr8v3p 46 21 90 90 CD cord-320054-wqpr8v3p 46 22 would would MD cord-320054-wqpr8v3p 46 23 result result VB cord-320054-wqpr8v3p 46 24 in in IN cord-320054-wqpr8v3p 46 25 losing lose VBG cord-320054-wqpr8v3p 46 26 efficacy efficacy NN cord-320054-wqpr8v3p 46 27 of of IN cord-320054-wqpr8v3p 46 28 the the DT cord-320054-wqpr8v3p 46 29 developed develop VBN cord-320054-wqpr8v3p 46 30 vaccines vaccine NNS cord-320054-wqpr8v3p 46 31 based base VBN cord-320054-wqpr8v3p 46 32 on on IN cord-320054-wqpr8v3p 46 33 prototype prototype NN cord-320054-wqpr8v3p 46 34 S s NN cord-320054-wqpr8v3p 46 35 protein protein NN cord-320054-wqpr8v3p 46 36 . . . cord-320054-wqpr8v3p 47 1 91 91 CD cord-320054-wqpr8v3p 48 1 Many many JJ cord-320054-wqpr8v3p 48 2 immuno immuno JJ cord-320054-wqpr8v3p 48 3 - - HYPH cord-320054-wqpr8v3p 48 4 bioinformatic bioinformatic JJ cord-320054-wqpr8v3p 48 5 tools tool NNS cord-320054-wqpr8v3p 48 6 have have VBP cord-320054-wqpr8v3p 48 7 been be VBN cord-320054-wqpr8v3p 48 8 developed develop VBN cord-320054-wqpr8v3p 48 9 to to TO cord-320054-wqpr8v3p 48 10 dope dope VB cord-320054-wqpr8v3p 48 11 out out RP cord-320054-wqpr8v3p 48 12 the the DT cord-320054-wqpr8v3p 48 13 overall overall JJ cord-320054-wqpr8v3p 48 14 92 92 CD cord-320054-wqpr8v3p 48 15 and and CC cord-320054-wqpr8v3p 48 16 deep deep JJ cord-320054-wqpr8v3p 48 17 analysis analysis NN cord-320054-wqpr8v3p 48 18 of of IN cord-320054-wqpr8v3p 48 19 viral viral JJ cord-320054-wqpr8v3p 48 20 antigens antigen NNS cord-320054-wqpr8v3p 48 21 , , , cord-320054-wqpr8v3p 48 22 including include VBG cord-320054-wqpr8v3p 48 23 both both DT cord-320054-wqpr8v3p 48 24 linear linear JJ cord-320054-wqpr8v3p 48 25 and and CC cord-320054-wqpr8v3p 48 26 discontinuous discontinuous JJ cord-320054-wqpr8v3p 48 27 epitopes epitope NNS cord-320054-wqpr8v3p 48 28 of of IN cord-320054-wqpr8v3p 48 29 93 93 CD cord-320054-wqpr8v3p 48 30 B b NN cord-320054-wqpr8v3p 48 31 - - HYPH cord-320054-wqpr8v3p 48 32 cells cell NNS cord-320054-wqpr8v3p 48 33 as as RB cord-320054-wqpr8v3p 48 34 well well RB cord-320054-wqpr8v3p 48 35 as as IN cord-320054-wqpr8v3p 48 36 their -PRON- PRP$ cord-320054-wqpr8v3p 48 37 immunogenicity immunogenicity NN cord-320054-wqpr8v3p 48 38 , , , cord-320054-wqpr8v3p 48 39 etc etc FW cord-320054-wqpr8v3p 48 40 . . . cord-320054-wqpr8v3p 49 1 To to TO cord-320054-wqpr8v3p 49 2 explore explore VB cord-320054-wqpr8v3p 49 3 these these DT cord-320054-wqpr8v3p 49 4 questions question NNS cord-320054-wqpr8v3p 49 5 , , , cord-320054-wqpr8v3p 49 6 here here RB cord-320054-wqpr8v3p 49 7 we -PRON- PRP cord-320054-wqpr8v3p 49 8 report report VBP cord-320054-wqpr8v3p 49 9 94 94 CD cord-320054-wqpr8v3p 49 10 to to TO cord-320054-wqpr8v3p 49 11 used use VBD cord-320054-wqpr8v3p 49 12 these these DT cord-320054-wqpr8v3p 49 13 immuno immuno JJ cord-320054-wqpr8v3p 49 14 - - JJ cord-320054-wqpr8v3p 49 15 bioinformatic bioinformatic JJ cord-320054-wqpr8v3p 49 16 tools tool NNS cord-320054-wqpr8v3p 49 17 from from IN cord-320054-wqpr8v3p 49 18 the the DT cord-320054-wqpr8v3p 49 19 IEDB IEDB NNP cord-320054-wqpr8v3p 49 20 and and CC cord-320054-wqpr8v3p 49 21 related related JJ cord-320054-wqpr8v3p 49 22 resources resource NNS cord-320054-wqpr8v3p 49 23 to to IN cord-320054-wqpr8v3p 49 24 95 95 CD cord-320054-wqpr8v3p 49 25 predict predict VBP cord-320054-wqpr8v3p 49 26 the the DT cord-320054-wqpr8v3p 49 27 B b NN cord-320054-wqpr8v3p 49 28 cell cell NN cord-320054-wqpr8v3p 49 29 epitopes epitope NNS cord-320054-wqpr8v3p 49 30 of of IN cord-320054-wqpr8v3p 49 31 S S NNP cord-320054-wqpr8v3p 49 32 protein protein NN cord-320054-wqpr8v3p 49 33 from from IN cord-320054-wqpr8v3p 49 34 the the DT cord-320054-wqpr8v3p 49 35 prototype prototype NN cord-320054-wqpr8v3p 49 36 and and CC cord-320054-wqpr8v3p 49 37 mutated mutate VBN cord-320054-wqpr8v3p 49 38 strains strain NNS cord-320054-wqpr8v3p 49 39 of of IN cord-320054-wqpr8v3p 49 40 96 96 CD cord-320054-wqpr8v3p 49 41 SARS SARS NNP cord-320054-wqpr8v3p 49 42 - - HYPH cord-320054-wqpr8v3p 49 43 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 49 44 and and CC cord-320054-wqpr8v3p 49 45 compare compare VB cord-320054-wqpr8v3p 49 46 the the DT cord-320054-wqpr8v3p 49 47 changes change NNS cord-320054-wqpr8v3p 49 48 of of IN cord-320054-wqpr8v3p 49 49 the the DT cord-320054-wqpr8v3p 49 50 likely likely JJ cord-320054-wqpr8v3p 49 51 epitope epitope NN cord-320054-wqpr8v3p 49 52 sites site NNS cord-320054-wqpr8v3p 49 53 from from IN cord-320054-wqpr8v3p 49 54 dominant dominant JJ cord-320054-wqpr8v3p 49 55 and and CC cord-320054-wqpr8v3p 49 56 97 97 CD cord-320054-wqpr8v3p 49 57 rare rare JJ cord-320054-wqpr8v3p 49 58 mutations mutation NNS cord-320054-wqpr8v3p 49 59 of of IN cord-320054-wqpr8v3p 49 60 S s NN cord-320054-wqpr8v3p 49 61 protein protein NN cord-320054-wqpr8v3p 49 62 . . . cord-320054-wqpr8v3p 50 1 We -PRON- PRP cord-320054-wqpr8v3p 50 2 found find VBD cord-320054-wqpr8v3p 50 3 that that IN cord-320054-wqpr8v3p 50 4 the the DT cord-320054-wqpr8v3p 50 5 distinctive distinctive JJ cord-320054-wqpr8v3p 50 6 mutations mutation NNS cord-320054-wqpr8v3p 50 7 of of IN cord-320054-wqpr8v3p 50 8 S s NN cord-320054-wqpr8v3p 50 9 proteins protein NNS cord-320054-wqpr8v3p 50 10 could could MD cord-320054-wqpr8v3p 50 11 98 98 CD cord-320054-wqpr8v3p 50 12 impact impact NN cord-320054-wqpr8v3p 50 13 potential potential JJ cord-320054-wqpr8v3p 50 14 effective effective JJ cord-320054-wqpr8v3p 50 15 epitopes epitope NNS cord-320054-wqpr8v3p 50 16 of of IN cord-320054-wqpr8v3p 50 17 S S NNP cord-320054-wqpr8v3p 50 18 proteins protein NNS cord-320054-wqpr8v3p 50 19 in in IN cord-320054-wqpr8v3p 50 20 different different JJ cord-320054-wqpr8v3p 50 21 degree degree NN cord-320054-wqpr8v3p 50 22 . . . cord-320054-wqpr8v3p 51 1 The the DT cord-320054-wqpr8v3p 51 2 exracellular exracellular JJ cord-320054-wqpr8v3p 51 3 domains domain NNS cord-320054-wqpr8v3p 51 4 divide divide VBP cord-320054-wqpr8v3p 51 5 into into IN cord-320054-wqpr8v3p 51 6 S1 s1 NN cord-320054-wqpr8v3p 51 7 and and CC cord-320054-wqpr8v3p 51 8 S2 S2 NNP cord-320054-wqpr8v3p 51 9 subunits subunit NNS cord-320054-wqpr8v3p 51 10 ; ; : cord-320054-wqpr8v3p 51 11 S1 S1 NNP cord-320054-wqpr8v3p 51 12 contains contain VBZ cord-320054-wqpr8v3p 51 13 the the DT cord-320054-wqpr8v3p 51 14 N n CD cord-320054-wqpr8v3p 51 15 - - HYPH cord-320054-wqpr8v3p 51 16 terminal terminal NN cord-320054-wqpr8v3p 51 17 137 137 CD cord-320054-wqpr8v3p 51 18 domain domain NN cord-320054-wqpr8v3p 51 19 ( ( -LRB- cord-320054-wqpr8v3p 51 20 NTD NTD NNP cord-320054-wqpr8v3p 51 21 ) ) -RRB- cord-320054-wqpr8v3p 51 22 and and CC cord-320054-wqpr8v3p 51 23 receptor receptor NN cord-320054-wqpr8v3p 51 24 binding bind VBG cord-320054-wqpr8v3p 51 25 domain domain NN cord-320054-wqpr8v3p 51 26 ( ( -LRB- cord-320054-wqpr8v3p 51 27 RBD RBD NNP cord-320054-wqpr8v3p 51 28 ) ) -RRB- cord-320054-wqpr8v3p 51 29 [ [ -LRB- cord-320054-wqpr8v3p 51 30 13 13 CD cord-320054-wqpr8v3p 51 31 ] ] -RRB- cord-320054-wqpr8v3p 51 32 . . . cord-320054-wqpr8v3p 52 1 Based base VBN cord-320054-wqpr8v3p 52 2 on on IN cord-320054-wqpr8v3p 52 3 the the DT cord-320054-wqpr8v3p 52 4 beginning beginning NN cord-320054-wqpr8v3p 52 5 and and CC cord-320054-wqpr8v3p 52 6 138 138 CD cord-320054-wqpr8v3p 52 7 end end NN cord-320054-wqpr8v3p 52 8 position position NN cord-320054-wqpr8v3p 52 9 of of IN cord-320054-wqpr8v3p 52 10 different different JJ cord-320054-wqpr8v3p 52 11 domains domain NNS cord-320054-wqpr8v3p 52 12 , , , cord-320054-wqpr8v3p 52 13 10 10 CD cord-320054-wqpr8v3p 52 14 major major JJ cord-320054-wqpr8v3p 52 15 mutations mutation NNS cord-320054-wqpr8v3p 52 16 were be VBD cord-320054-wqpr8v3p 52 17 shown show VBN cord-320054-wqpr8v3p 52 18 in in IN cord-320054-wqpr8v3p 52 19 the the DT cord-320054-wqpr8v3p 52 20 schematic schematic JJ cord-320054-wqpr8v3p 52 21 139 139 CD cord-320054-wqpr8v3p 52 22 diagram diagram NN cord-320054-wqpr8v3p 52 23 of of IN cord-320054-wqpr8v3p 52 24 S S NNP cord-320054-wqpr8v3p 52 25 protein protein NN cord-320054-wqpr8v3p 52 26 ( ( -LRB- cord-320054-wqpr8v3p 52 27 Figure figure NN cord-320054-wqpr8v3p 52 28 1A 1a NN cord-320054-wqpr8v3p 52 29 ) ) -RRB- cord-320054-wqpr8v3p 52 30 . . . cord-320054-wqpr8v3p 53 1 We -PRON- PRP cord-320054-wqpr8v3p 53 2 found find VBD cord-320054-wqpr8v3p 53 3 that that IN cord-320054-wqpr8v3p 53 4 most most JJS cord-320054-wqpr8v3p 53 5 of of IN cord-320054-wqpr8v3p 53 6 S S NNP cord-320054-wqpr8v3p 53 7 protein protein NN cord-320054-wqpr8v3p 53 8 mutations mutation NNS cord-320054-wqpr8v3p 53 9 ( ( -LRB- cord-320054-wqpr8v3p 53 10 70 70 CD cord-320054-wqpr8v3p 53 11 % % NN cord-320054-wqpr8v3p 53 12 ) ) -RRB- cord-320054-wqpr8v3p 54 1 140 140 CD cord-320054-wqpr8v3p 54 2 locates locate VBZ cord-320054-wqpr8v3p 54 3 in in IN cord-320054-wqpr8v3p 54 4 S1 s1 NN cord-320054-wqpr8v3p 54 5 and and CC cord-320054-wqpr8v3p 54 6 near near IN cord-320054-wqpr8v3p 54 7 region region NN cord-320054-wqpr8v3p 54 8 of of IN cord-320054-wqpr8v3p 54 9 S S NNP cord-320054-wqpr8v3p 54 10 protein protein NN cord-320054-wqpr8v3p 54 11 . . . cord-320054-wqpr8v3p 55 1 The the DT cord-320054-wqpr8v3p 55 2 highest high JJS cord-320054-wqpr8v3p 55 3 mutation mutation NN cord-320054-wqpr8v3p 55 4 D614 d614 CD cord-320054-wqpr8v3p 55 5 G g NN cord-320054-wqpr8v3p 55 6 is be VBZ cord-320054-wqpr8v3p 55 7 near near IN cord-320054-wqpr8v3p 55 8 RBD RBD NNP cord-320054-wqpr8v3p 55 9 To to TO cord-320054-wqpr8v3p 55 10 predict predict VB cord-320054-wqpr8v3p 55 11 the the DT cord-320054-wqpr8v3p 55 12 potential potential JJ cord-320054-wqpr8v3p 55 13 linear linear JJ cord-320054-wqpr8v3p 55 14 B b NN cord-320054-wqpr8v3p 55 15 - - HYPH cord-320054-wqpr8v3p 55 16 cell cell NN cord-320054-wqpr8v3p 55 17 epitopes epitope NNS cord-320054-wqpr8v3p 55 18 , , , cord-320054-wqpr8v3p 55 19 we -PRON- PRP cord-320054-wqpr8v3p 55 20 first first RB cord-320054-wqpr8v3p 55 21 used use VBD cord-320054-wqpr8v3p 55 22 BepiPred-2.0 BepiPred-2.0 NNP cord-320054-wqpr8v3p 55 23 155 155 CD cord-320054-wqpr8v3p 55 24 prediction prediction NN cord-320054-wqpr8v3p 55 25 tool tool NN cord-320054-wqpr8v3p 55 26 on on IN cord-320054-wqpr8v3p 55 27 IEDB IEDB NNP cord-320054-wqpr8v3p 55 28 server server NN cord-320054-wqpr8v3p 55 29 to to TO cord-320054-wqpr8v3p 55 30 screen screen VB cord-320054-wqpr8v3p 55 31 the the DT cord-320054-wqpr8v3p 55 32 prototype prototype NN cord-320054-wqpr8v3p 55 33 S s NN cord-320054-wqpr8v3p 55 34 protein protein NN cord-320054-wqpr8v3p 55 35 sequence sequence NN cord-320054-wqpr8v3p 55 36 and and CC cord-320054-wqpr8v3p 55 37 156 156 CD cord-320054-wqpr8v3p 55 38 discovered discover VBD cord-320054-wqpr8v3p 55 39 total total JJ cord-320054-wqpr8v3p 55 40 30 30 CD cord-320054-wqpr8v3p 55 41 B b NN cord-320054-wqpr8v3p 55 42 - - HYPH cord-320054-wqpr8v3p 55 43 cell cell NN cord-320054-wqpr8v3p 55 44 linear linear JJ cord-320054-wqpr8v3p 55 45 epitopes epitope NNS cord-320054-wqpr8v3p 55 46 ( ( -LRB- cord-320054-wqpr8v3p 55 47 Table Table NNP cord-320054-wqpr8v3p 55 48 S2 S2 NNP cord-320054-wqpr8v3p 55 49 ) ) -RRB- cord-320054-wqpr8v3p 55 50 , , , cord-320054-wqpr8v3p 55 51 whose whose WP$ cord-320054-wqpr8v3p 55 52 distribution distribution NN cord-320054-wqpr8v3p 55 53 is be VBZ cord-320054-wqpr8v3p 55 54 shown show VBN cord-320054-wqpr8v3p 55 55 on on IN cord-320054-wqpr8v3p 55 56 Table Table NNP cord-320054-wqpr8v3p 55 57 2 2 CD cord-320054-wqpr8v3p 55 58 . . . cord-320054-wqpr8v3p 56 1 Among among IN cord-320054-wqpr8v3p 56 2 them -PRON- PRP cord-320054-wqpr8v3p 56 3 , , , cord-320054-wqpr8v3p 56 4 9 9 CD cord-320054-wqpr8v3p 56 5 epitopes epitope NNS cord-320054-wqpr8v3p 56 6 are be VBP cord-320054-wqpr8v3p 56 7 in in IN cord-320054-wqpr8v3p 56 8 S1 s1 NN cord-320054-wqpr8v3p 56 9 subunit subunit NN cord-320054-wqpr8v3p 56 10 4 4 CD cord-320054-wqpr8v3p 56 11 in in IN cord-320054-wqpr8v3p 56 12 the the DT cord-320054-wqpr8v3p 56 13 NTD NTD NNP cord-320054-wqpr8v3p 56 14 region region NN cord-320054-wqpr8v3p 56 15 , , , cord-320054-wqpr8v3p 56 16 5 5 CD cord-320054-wqpr8v3p 56 17 in in IN cord-320054-wqpr8v3p 56 18 163 163 CD cord-320054-wqpr8v3p 56 19 the the DT cord-320054-wqpr8v3p 56 20 RBD RBD NNP cord-320054-wqpr8v3p 56 21 domain domain NN cord-320054-wqpr8v3p 56 22 ) ) -RRB- cord-320054-wqpr8v3p 56 23 and and CC cord-320054-wqpr8v3p 56 24 3 3 CD cord-320054-wqpr8v3p 56 25 in in IN cord-320054-wqpr8v3p 56 26 the the DT cord-320054-wqpr8v3p 56 27 S2 S2 NNP cord-320054-wqpr8v3p 56 28 subunit subunit NN cord-320054-wqpr8v3p 56 29 of of IN cord-320054-wqpr8v3p 56 30 S S NNP cord-320054-wqpr8v3p 56 31 protein protein NN cord-320054-wqpr8v3p 56 32 . . . cord-320054-wqpr8v3p 57 1 Based base VBN cord-320054-wqpr8v3p 57 2 on on IN cord-320054-wqpr8v3p 57 3 this this DT cord-320054-wqpr8v3p 57 4 analysis analysis NN cord-320054-wqpr8v3p 57 5 , , , cord-320054-wqpr8v3p 57 6 we -PRON- PRP cord-320054-wqpr8v3p 57 7 164 164 CD cord-320054-wqpr8v3p 57 8 found find VBD cord-320054-wqpr8v3p 57 9 that that IN cord-320054-wqpr8v3p 57 10 three three CD cord-320054-wqpr8v3p 57 11 epitopes epitope NNS cord-320054-wqpr8v3p 57 12 in in IN cord-320054-wqpr8v3p 57 13 the the DT cord-320054-wqpr8v3p 57 14 RBD RBD NNP cord-320054-wqpr8v3p 57 15 domain domain NN cord-320054-wqpr8v3p 57 16 ( ( -LRB- cord-320054-wqpr8v3p 57 17 384 384 CD cord-320054-wqpr8v3p 57 18 PTKLNDL PTKLNDL NNP cord-320054-wqpr8v3p 57 19 390 390 CD cord-320054-wqpr8v3p 57 20 , , , cord-320054-wqpr8v3p 57 21 9 9 CD cord-320054-wqpr8v3p 57 22 165 165 CD cord-320054-wqpr8v3p 57 23 405 405 CD cord-320054-wqpr8v3p 57 24 DEVRQIAPGQTGKI DEVRQIAPGQTGKI NNP cord-320054-wqpr8v3p 57 25 418 418 CD cord-320054-wqpr8v3p 57 26 , , , cord-320054-wqpr8v3p 57 27 and and CC cord-320054-wqpr8v3p 57 28 487 487 CD cord-320054-wqpr8v3p 57 29 NCYFPL NCYFPL NNP cord-320054-wqpr8v3p 57 30 492 492 CD cord-320054-wqpr8v3p 57 31 ) ) -RRB- cord-320054-wqpr8v3p 57 32 have have VBP cord-320054-wqpr8v3p 57 33 more more RBR cord-320054-wqpr8v3p 57 34 significant significant JJ cord-320054-wqpr8v3p 57 35 antigenicity antigenicity NN cord-320054-wqpr8v3p 57 36 and and CC cord-320054-wqpr8v3p 57 37 166 166 CD cord-320054-wqpr8v3p 57 38 accessibility accessibility NN cord-320054-wqpr8v3p 57 39 . . . cord-320054-wqpr8v3p 58 1 167 167 CD cord-320054-wqpr8v3p 59 1 We -PRON- PRP cord-320054-wqpr8v3p 59 2 further further RB cord-320054-wqpr8v3p 59 3 predicted predict VBD cord-320054-wqpr8v3p 59 4 the the DT cord-320054-wqpr8v3p 59 5 discontinuous discontinuous JJ cord-320054-wqpr8v3p 59 6 epitopes epitope NNS cord-320054-wqpr8v3p 59 7 by by IN cord-320054-wqpr8v3p 59 8 the the DT cord-320054-wqpr8v3p 59 9 Discotope Discotope NNP cord-320054-wqpr8v3p 59 10 2.0 2.0 CD cord-320054-wqpr8v3p 59 11 online online NN cord-320054-wqpr8v3p 59 12 168 168 CD cord-320054-wqpr8v3p 59 13 server server NN cord-320054-wqpr8v3p 59 14 . . . cord-320054-wqpr8v3p 60 1 3D 3d JJ cord-320054-wqpr8v3p 60 2 structure structure NN cord-320054-wqpr8v3p 60 3 of of IN cord-320054-wqpr8v3p 60 4 S S NNP cord-320054-wqpr8v3p 60 5 protein protein NN cord-320054-wqpr8v3p 60 6 ( ( -LRB- cord-320054-wqpr8v3p 60 7 PDB PDB NNP cord-320054-wqpr8v3p 60 8 ID ID NNP cord-320054-wqpr8v3p 60 9 : : : cord-320054-wqpr8v3p 61 1 6vyb 6vyb CD cord-320054-wqpr8v3p 61 2 , , , cord-320054-wqpr8v3p 61 3 Chain Chain NNP cord-320054-wqpr8v3p 61 4 ID ID NNP cord-320054-wqpr8v3p 61 5 : : : cord-320054-wqpr8v3p 61 6 A a NN cord-320054-wqpr8v3p 61 7 ) ) -RRB- cord-320054-wqpr8v3p 61 8 was be VBD cord-320054-wqpr8v3p 61 9 utilized utilize VBN cord-320054-wqpr8v3p 61 10 to to TO cord-320054-wqpr8v3p 61 11 predict predict VB cord-320054-wqpr8v3p 61 12 169 169 CD cord-320054-wqpr8v3p 61 13 the the DT cord-320054-wqpr8v3p 61 14 discontinuous discontinuous JJ cord-320054-wqpr8v3p 61 15 epitopes epitope NNS cord-320054-wqpr8v3p 61 16 . . . cord-320054-wqpr8v3p 62 1 The the DT cord-320054-wqpr8v3p 62 2 default default NN cord-320054-wqpr8v3p 62 3 threshold threshold NN cord-320054-wqpr8v3p 62 4 was be VBD cord-320054-wqpr8v3p 62 5 −3.7 −3.7 VBN cord-320054-wqpr8v3p 62 6 with with IN cord-320054-wqpr8v3p 62 7 47 47 CD cord-320054-wqpr8v3p 62 8 % % NN cord-320054-wqpr8v3p 62 9 of of IN cord-320054-wqpr8v3p 62 10 Sensitivity sensitivity NN cord-320054-wqpr8v3p 62 11 and and CC cord-320054-wqpr8v3p 62 12 170 170 CD cord-320054-wqpr8v3p 62 13 75 75 CD cord-320054-wqpr8v3p 62 14 % % NN cord-320054-wqpr8v3p 62 15 of of IN cord-320054-wqpr8v3p 62 16 Specificity Specificity NNP cord-320054-wqpr8v3p 62 17 . . . cord-320054-wqpr8v3p 63 1 The the DT cord-320054-wqpr8v3p 63 2 53 53 CD cord-320054-wqpr8v3p 63 3 discontinuous discontinuous JJ cord-320054-wqpr8v3p 63 4 epitopes epitope NNS cord-320054-wqpr8v3p 63 5 were be VBD cord-320054-wqpr8v3p 63 6 predicted predict VBN cord-320054-wqpr8v3p 63 7 and and CC cord-320054-wqpr8v3p 63 8 mainly mainly RB cord-320054-wqpr8v3p 63 9 located locate VBN cord-320054-wqpr8v3p 63 10 171 171 CD cord-320054-wqpr8v3p 63 11 in in IN cord-320054-wqpr8v3p 63 12 the the DT cord-320054-wqpr8v3p 63 13 whole whole JJ cord-320054-wqpr8v3p 63 14 RBD RBD NNP cord-320054-wqpr8v3p 63 15 region region NN cord-320054-wqpr8v3p 63 16 at at IN cord-320054-wqpr8v3p 63 17 400aa~600aa 400aa~600aa CD cord-320054-wqpr8v3p 63 18 of of IN cord-320054-wqpr8v3p 63 19 S S NNP cord-320054-wqpr8v3p 63 20 protein protein NN cord-320054-wqpr8v3p 63 21 shown show VBN cord-320054-wqpr8v3p 63 22 in in IN cord-320054-wqpr8v3p 63 23 Figure Figure NNP cord-320054-wqpr8v3p 63 24 3A 3a NN cord-320054-wqpr8v3p 63 25 . . . cord-320054-wqpr8v3p 64 1 All all DT cord-320054-wqpr8v3p 64 2 of of IN cord-320054-wqpr8v3p 64 3 the the DT cord-320054-wqpr8v3p 64 4 172 172 CD cord-320054-wqpr8v3p 64 5 predicted predict VBD cord-320054-wqpr8v3p 64 6 epitopes epitope NNS cord-320054-wqpr8v3p 64 7 distributing distribute VBG cord-320054-wqpr8v3p 64 8 on on IN cord-320054-wqpr8v3p 64 9 surface surface NN cord-320054-wqpr8v3p 64 10 of of IN cord-320054-wqpr8v3p 64 11 S s NN cord-320054-wqpr8v3p 64 12 protein protein NN cord-320054-wqpr8v3p 64 13 are be VBP cord-320054-wqpr8v3p 64 14 shown show VBN cord-320054-wqpr8v3p 64 15 in in IN cord-320054-wqpr8v3p 64 16 a a DT cord-320054-wqpr8v3p 64 17 3D 3d JJ cord-320054-wqpr8v3p 64 18 structure structure NN cord-320054-wqpr8v3p 64 19 173 173 CD cord-320054-wqpr8v3p 64 20 picture picture NN cord-320054-wqpr8v3p 64 21 in in IN cord-320054-wqpr8v3p 64 22 Figure figure NN cord-320054-wqpr8v3p 64 23 3B 3b NN cord-320054-wqpr8v3p 64 24 using use VBG cord-320054-wqpr8v3p 64 25 JSmol JSmol NNP cord-320054-wqpr8v3p 64 26 Viewer Viewer NNP cord-320054-wqpr8v3p 64 27 . . . cord-320054-wqpr8v3p 65 1 According accord VBG cord-320054-wqpr8v3p 65 2 to to IN cord-320054-wqpr8v3p 65 3 the the DT cord-320054-wqpr8v3p 65 4 distribution distribution NN cord-320054-wqpr8v3p 65 5 in in IN cord-320054-wqpr8v3p 65 6 different different JJ cord-320054-wqpr8v3p 65 7 174 174 CD cord-320054-wqpr8v3p 65 8 domains domain NNS cord-320054-wqpr8v3p 65 9 , , , cord-320054-wqpr8v3p 65 10 these these DT cord-320054-wqpr8v3p 65 11 epitopes epitope NNS cord-320054-wqpr8v3p 65 12 ( ( -LRB- cord-320054-wqpr8v3p 65 13 Table Table NNP cord-320054-wqpr8v3p 65 14 S3 S3 NNP cord-320054-wqpr8v3p 65 15 ) ) -RRB- cord-320054-wqpr8v3p 65 16 could could MD cord-320054-wqpr8v3p 65 17 be be VB cord-320054-wqpr8v3p 65 18 divided divide VBN cord-320054-wqpr8v3p 65 19 into into IN cord-320054-wqpr8v3p 65 20 four four CD cord-320054-wqpr8v3p 65 21 groups group NNS cord-320054-wqpr8v3p 65 22 ( ( -LRB- cord-320054-wqpr8v3p 65 23 Table Table NNP cord-320054-wqpr8v3p 65 24 3 3 CD cord-320054-wqpr8v3p 65 25 ) ) -RRB- cord-320054-wqpr8v3p 65 26 and and CC cord-320054-wqpr8v3p 65 27 the the DT cord-320054-wqpr8v3p 65 28 175 175 CD cord-320054-wqpr8v3p 65 29 highest high JJS cord-320054-wqpr8v3p 65 30 propensity propensity NN cord-320054-wqpr8v3p 65 31 score score NN cord-320054-wqpr8v3p 65 32 ( ( -LRB- cord-320054-wqpr8v3p 65 33 P p NN cord-320054-wqpr8v3p 65 34 - - HYPH cord-320054-wqpr8v3p 65 35 Score score NN cord-320054-wqpr8v3p 65 36 ) ) -RRB- cord-320054-wqpr8v3p 65 37 and and CC cord-320054-wqpr8v3p 65 38 DiscoTope DiscoTope NNP cord-320054-wqpr8v3p 65 39 score score NN cord-320054-wqpr8v3p 65 40 ( ( -LRB- cord-320054-wqpr8v3p 65 41 D D NNP cord-320054-wqpr8v3p 65 42 - - HYPH cord-320054-wqpr8v3p 65 43 Score score NN cord-320054-wqpr8v3p 65 44 ) ) -RRB- cord-320054-wqpr8v3p 65 45 of of IN cord-320054-wqpr8v3p 65 46 epitopes epitope NNS cord-320054-wqpr8v3p 65 47 were be VBD cord-320054-wqpr8v3p 65 48 176 176 CD cord-320054-wqpr8v3p 65 49 concentrated concentrate VBD cord-320054-wqpr8v3p 65 50 at at IN cord-320054-wqpr8v3p 65 51 498~500aa 498~500aa CD cord-320054-wqpr8v3p 65 52 of of IN cord-320054-wqpr8v3p 65 53 RBD RBD NNP cord-320054-wqpr8v3p 65 54 region region NN cord-320054-wqpr8v3p 65 55 shown show VBN cord-320054-wqpr8v3p 65 56 by by IN cord-320054-wqpr8v3p 65 57 arrows arrow NNS cord-320054-wqpr8v3p 65 58 in in IN cord-320054-wqpr8v3p 65 59 the the DT cord-320054-wqpr8v3p 65 60 Figure figure NN cord-320054-wqpr8v3p 65 61 3B 3b NN cord-320054-wqpr8v3p 65 62 . . . cord-320054-wqpr8v3p 66 1 177 177 CD cord-320054-wqpr8v3p 67 1 Finally finally RB cord-320054-wqpr8v3p 67 2 , , , cord-320054-wqpr8v3p 67 3 these these DT cord-320054-wqpr8v3p 67 4 epitopes epitope NNS cord-320054-wqpr8v3p 67 5 were be VBD cord-320054-wqpr8v3p 67 6 validated validate VBN cord-320054-wqpr8v3p 67 7 by by IN cord-320054-wqpr8v3p 67 8 Pepitope Pepitope NNP cord-320054-wqpr8v3p 67 9 tool tool NN cord-320054-wqpr8v3p 67 10 ( ( -LRB- cord-320054-wqpr8v3p 67 11 http://pepitope.tau.ac.il/ http://pepitope.tau.ac.il/ NNP cord-320054-wqpr8v3p 67 12 ) ) -RRB- cord-320054-wqpr8v3p 67 13 , , , cord-320054-wqpr8v3p 67 14 178 178 CD cord-320054-wqpr8v3p 67 15 the the DT cord-320054-wqpr8v3p 67 16 three three CD cord-320054-wqpr8v3p 67 17 major major JJ cord-320054-wqpr8v3p 67 18 antigen antigen NN cord-320054-wqpr8v3p 67 19 clusters cluster NNS cord-320054-wqpr8v3p 67 20 were be VBD cord-320054-wqpr8v3p 67 21 consistent consistent JJ cord-320054-wqpr8v3p 67 22 with with IN cord-320054-wqpr8v3p 67 23 B b NN cord-320054-wqpr8v3p 67 24 - - HYPH cord-320054-wqpr8v3p 67 25 linear linear JJ cord-320054-wqpr8v3p 67 26 epitopes epitope NNS cord-320054-wqpr8v3p 67 27 mentioned mention VBD cord-320054-wqpr8v3p 67 28 179 179 CD cord-320054-wqpr8v3p 67 29 above above RB cord-320054-wqpr8v3p 67 30 ( ( -LRB- cord-320054-wqpr8v3p 67 31 Table table NN cord-320054-wqpr8v3p 67 32 4 4 CD cord-320054-wqpr8v3p 67 33 ) ) -RRB- cord-320054-wqpr8v3p 67 34 . . . cord-320054-wqpr8v3p 68 1 By by IN cord-320054-wqpr8v3p 68 2 assessment assessment NN cord-320054-wqpr8v3p 68 3 for for IN cord-320054-wqpr8v3p 68 4 its -PRON- PRP$ cord-320054-wqpr8v3p 68 5 antigenicity antigenicity NN cord-320054-wqpr8v3p 68 6 and and CC cord-320054-wqpr8v3p 68 7 surface surface NN cord-320054-wqpr8v3p 68 8 202 202 CD cord-320054-wqpr8v3p 68 9 availability availability NN cord-320054-wqpr8v3p 68 10 , , , cord-320054-wqpr8v3p 68 11 we -PRON- PRP cord-320054-wqpr8v3p 68 12 found find VBD cord-320054-wqpr8v3p 68 13 that that IN cord-320054-wqpr8v3p 68 14 four four CD cord-320054-wqpr8v3p 68 15 epitopes epitope NNS cord-320054-wqpr8v3p 68 16 have have VBP cord-320054-wqpr8v3p 68 17 changed change VBN cord-320054-wqpr8v3p 68 18 ( ( -LRB- cord-320054-wqpr8v3p 68 19 Table table NN cord-320054-wqpr8v3p 68 20 S4 S4 NNP cord-320054-wqpr8v3p 68 21 ) ) -RRB- cord-320054-wqpr8v3p 68 22 . . . cord-320054-wqpr8v3p 69 1 In in IN cord-320054-wqpr8v3p 69 2 brief brief NN cord-320054-wqpr8v3p 69 3 , , , cord-320054-wqpr8v3p 69 4 after after IN cord-320054-wqpr8v3p 69 5 H49Y H49Y NNP cord-320054-wqpr8v3p 69 6 203 203 CD cord-320054-wqpr8v3p 69 7 mutation mutation NN cord-320054-wqpr8v3p 69 8 , , , cord-320054-wqpr8v3p 69 9 the the DT cord-320054-wqpr8v3p 69 10 S S NNP cord-320054-wqpr8v3p 69 11 protein protein NN cord-320054-wqpr8v3p 69 12 had have VBD cord-320054-wqpr8v3p 69 13 14 14 CD cord-320054-wqpr8v3p 69 14 effective effective JJ cord-320054-wqpr8v3p 69 15 epitopes epitope NNS cord-320054-wqpr8v3p 69 16 , , , cord-320054-wqpr8v3p 69 17 two two CD cord-320054-wqpr8v3p 69 18 of of IN cord-320054-wqpr8v3p 69 19 which which WDT cord-320054-wqpr8v3p 69 20 have have VBP cord-320054-wqpr8v3p 69 21 better well JJR cord-320054-wqpr8v3p 69 22 antigenicity antigenicity NN cord-320054-wqpr8v3p 69 23 204 204 CD cord-320054-wqpr8v3p 69 24 than than IN cord-320054-wqpr8v3p 69 25 original original JJ cord-320054-wqpr8v3p 69 26 epitopes epitope NNS cord-320054-wqpr8v3p 69 27 at at IN cord-320054-wqpr8v3p 69 28 site site NN cord-320054-wqpr8v3p 69 29 of of IN cord-320054-wqpr8v3p 69 30 405~417 405~417 CD cord-320054-wqpr8v3p 69 31 and and CC cord-320054-wqpr8v3p 69 32 697~709 697~709 NN cord-320054-wqpr8v3p 69 33 , , , cord-320054-wqpr8v3p 69 34 two two CD cord-320054-wqpr8v3p 69 35 of of IN cord-320054-wqpr8v3p 69 36 which which WDT cord-320054-wqpr8v3p 69 37 were be VBD cord-320054-wqpr8v3p 69 38 newly newly RB cord-320054-wqpr8v3p 69 39 205 205 CD cord-320054-wqpr8v3p 69 40 generated generate VBN cord-320054-wqpr8v3p 69 41 at at IN cord-320054-wqpr8v3p 69 42 sites site NNS cord-320054-wqpr8v3p 69 43 of of IN cord-320054-wqpr8v3p 69 44 519~533 519~533 CD cord-320054-wqpr8v3p 69 45 and and CC cord-320054-wqpr8v3p 69 46 618~629 618~629 CD cord-320054-wqpr8v3p 69 47 , , , cord-320054-wqpr8v3p 69 48 and and CC cord-320054-wqpr8v3p 69 49 the the DT cord-320054-wqpr8v3p 69 50 remaining remain VBG cord-320054-wqpr8v3p 69 51 10 10 CD cord-320054-wqpr8v3p 69 52 epitopes epitope NNS cord-320054-wqpr8v3p 69 53 were be VBD cord-320054-wqpr8v3p 69 54 the the DT cord-320054-wqpr8v3p 69 55 206 206 CD cord-320054-wqpr8v3p 69 56 same same JJ cord-320054-wqpr8v3p 69 57 as as IN cord-320054-wqpr8v3p 69 58 those those DT cord-320054-wqpr8v3p 69 59 without without IN cord-320054-wqpr8v3p 69 60 mutation mutation NN cord-320054-wqpr8v3p 69 61 . . . cord-320054-wqpr8v3p 70 1 207 207 CD cord-320054-wqpr8v3p 70 2 208 208 CD cord-320054-wqpr8v3p 70 3 Y145H Y145H NNPS cord-320054-wqpr8v3p 70 4 mutation mutation NN cord-320054-wqpr8v3p 70 5 11 11 CD cord-320054-wqpr8v3p 71 1 209 209 CD cord-320054-wqpr8v3p 71 2 Y145H y145h NN cord-320054-wqpr8v3p 71 3 mutation mutation NN cord-320054-wqpr8v3p 71 4 occurred occur VBD cord-320054-wqpr8v3p 71 5 in in IN cord-320054-wqpr8v3p 71 6 8 8 CD cord-320054-wqpr8v3p 71 7 countries country NNS cord-320054-wqpr8v3p 71 8 , , , cord-320054-wqpr8v3p 71 9 but but CC cord-320054-wqpr8v3p 71 10 the the DT cord-320054-wqpr8v3p 71 11 frequency frequency NN cord-320054-wqpr8v3p 71 12 appeared appear VBD cord-320054-wqpr8v3p 71 13 to to TO cord-320054-wqpr8v3p 71 14 decrease decrease VB cord-320054-wqpr8v3p 71 15 now now RB cord-320054-wqpr8v3p 71 16 210 210 CD cord-320054-wqpr8v3p 71 17 [ [ -LRB- cord-320054-wqpr8v3p 71 18 12 12 CD cord-320054-wqpr8v3p 71 19 ] ] -RRB- cord-320054-wqpr8v3p 71 20 . . . cord-320054-wqpr8v3p 72 1 By by IN cord-320054-wqpr8v3p 72 2 using use VBG cord-320054-wqpr8v3p 72 3 the the DT cord-320054-wqpr8v3p 72 4 screening screening NN cord-320054-wqpr8v3p 72 5 methods method NNS cord-320054-wqpr8v3p 72 6 above above RB cord-320054-wqpr8v3p 72 7 , , , cord-320054-wqpr8v3p 72 8 we -PRON- PRP cord-320054-wqpr8v3p 72 9 found find VBD cord-320054-wqpr8v3p 72 10 that that IN cord-320054-wqpr8v3p 72 11 five five CD cord-320054-wqpr8v3p 72 12 altering alter VBG cord-320054-wqpr8v3p 72 13 sites site NNS cord-320054-wqpr8v3p 72 14 have have VBP cord-320054-wqpr8v3p 72 15 211 211 CD cord-320054-wqpr8v3p 72 16 distinct distinct JJ cord-320054-wqpr8v3p 72 17 influences influence NNS cord-320054-wqpr8v3p 72 18 on on IN cord-320054-wqpr8v3p 72 19 the the DT cord-320054-wqpr8v3p 72 20 likely likely JJ cord-320054-wqpr8v3p 72 21 epitopes epitope NNS cord-320054-wqpr8v3p 72 22 ( ( -LRB- cord-320054-wqpr8v3p 72 23 Table Table NNP cord-320054-wqpr8v3p 72 24 S5 S5 NNP cord-320054-wqpr8v3p 72 25 ) ) -RRB- cord-320054-wqpr8v3p 72 26 . . . cord-320054-wqpr8v3p 73 1 Y145H y145h NN cord-320054-wqpr8v3p 73 2 mutation mutation NN cord-320054-wqpr8v3p 73 3 emerging emerge VBG cord-320054-wqpr8v3p 73 4 , , , cord-320054-wqpr8v3p 73 5 the the DT cord-320054-wqpr8v3p 73 6 S S NNP cord-320054-wqpr8v3p 73 7 212 212 CD cord-320054-wqpr8v3p 73 8 protein protein NN cord-320054-wqpr8v3p 73 9 had have VBD cord-320054-wqpr8v3p 73 10 13 13 CD cord-320054-wqpr8v3p 73 11 effective effective JJ cord-320054-wqpr8v3p 73 12 epitopes epitope NNS cord-320054-wqpr8v3p 73 13 , , , cord-320054-wqpr8v3p 73 14 two two CD cord-320054-wqpr8v3p 73 15 of of IN cord-320054-wqpr8v3p 73 16 which which WDT cord-320054-wqpr8v3p 73 17 were be VBD cord-320054-wqpr8v3p 73 18 newly newly RB cord-320054-wqpr8v3p 73 19 produced produce VBN cord-320054-wqpr8v3p 73 20 from from IN cord-320054-wqpr8v3p 73 21 originally originally RB cord-320054-wqpr8v3p 73 22 213 213 CD cord-320054-wqpr8v3p 73 23 unlikely unlikely JJ cord-320054-wqpr8v3p 73 24 epitopes epitope NNS cord-320054-wqpr8v3p 73 25 at at IN cord-320054-wqpr8v3p 73 26 sites site NNS cord-320054-wqpr8v3p 73 27 of of IN cord-320054-wqpr8v3p 73 28 618~625 618~625 CD cord-320054-wqpr8v3p 73 29 , , , cord-320054-wqpr8v3p 73 30 three three CD cord-320054-wqpr8v3p 73 31 of of IN cord-320054-wqpr8v3p 73 32 which which WDT cord-320054-wqpr8v3p 73 33 have have VBP cord-320054-wqpr8v3p 73 34 better well JJR cord-320054-wqpr8v3p 73 35 antigenicity antigenicity NN cord-320054-wqpr8v3p 73 36 than than IN cord-320054-wqpr8v3p 73 37 214 214 CD cord-320054-wqpr8v3p 73 38 original original JJ cord-320054-wqpr8v3p 73 39 epitopes epitope NNS cord-320054-wqpr8v3p 73 40 at at IN cord-320054-wqpr8v3p 73 41 site site NN cord-320054-wqpr8v3p 73 42 of of IN cord-320054-wqpr8v3p 73 43 140~153 140~153 CD cord-320054-wqpr8v3p 73 44 , , , cord-320054-wqpr8v3p 73 45 459~465 459~465 CD cord-320054-wqpr8v3p 73 46 and and CC cord-320054-wqpr8v3p 73 47 657~663 657~663 CD cord-320054-wqpr8v3p 73 48 , , , cord-320054-wqpr8v3p 73 49 and and CC cord-320054-wqpr8v3p 73 50 the the DT cord-320054-wqpr8v3p 73 51 remaining remain VBG cord-320054-wqpr8v3p 73 52 9 9 CD cord-320054-wqpr8v3p 73 53 215 215 CD cord-320054-wqpr8v3p 73 54 epitopes epitope NNS cord-320054-wqpr8v3p 73 55 were be VBD cord-320054-wqpr8v3p 73 56 conservative conservative JJ cord-320054-wqpr8v3p 73 57 . . . cord-320054-wqpr8v3p 74 1 The the DT cord-320054-wqpr8v3p 74 2 epitope epitope NN cord-320054-wqpr8v3p 74 3 at at IN cord-320054-wqpr8v3p 74 4 site site NN cord-320054-wqpr8v3p 74 5 486~492 486~492 CD cord-320054-wqpr8v3p 74 6 was be VBD cord-320054-wqpr8v3p 74 7 reduced reduce VBN cord-320054-wqpr8v3p 74 8 antigenicity antigenicity NN cord-320054-wqpr8v3p 74 9 slightly slightly RB cord-320054-wqpr8v3p 74 10 . . . cord-320054-wqpr8v3p 75 1 Therefore therefore RB cord-320054-wqpr8v3p 75 2 , , , cord-320054-wqpr8v3p 75 3 9 9 CD cord-320054-wqpr8v3p 75 4 effective effective JJ cord-320054-wqpr8v3p 75 5 238 238 CD cord-320054-wqpr8v3p 75 6 epitopes epitope NNS cord-320054-wqpr8v3p 75 7 have have VBP cord-320054-wqpr8v3p 75 8 predicted predict VBN cord-320054-wqpr8v3p 75 9 after after IN cord-320054-wqpr8v3p 75 10 G476S G476S NNP cord-320054-wqpr8v3p 75 11 mutation mutation NN cord-320054-wqpr8v3p 75 12 , , , cord-320054-wqpr8v3p 75 13 in in IN cord-320054-wqpr8v3p 75 14 which which WDT cord-320054-wqpr8v3p 75 15 the the DT cord-320054-wqpr8v3p 75 16 amount amount NN cord-320054-wqpr8v3p 75 17 of of IN cord-320054-wqpr8v3p 75 18 239 239 CD cord-320054-wqpr8v3p 75 19 epitope epitope NN cord-320054-wqpr8v3p 75 20 - - HYPH cord-320054-wqpr8v3p 75 21 changing change VBG cord-320054-wqpr8v3p 75 22 is be VBZ cord-320054-wqpr8v3p 75 23 the the DT cord-320054-wqpr8v3p 75 24 most most JJS cord-320054-wqpr8v3p 75 25 , , , cord-320054-wqpr8v3p 75 26 and and CC cord-320054-wqpr8v3p 75 27 the the DT cord-320054-wqpr8v3p 75 28 overall overall JJ cord-320054-wqpr8v3p 75 29 antigenicity antigenicity NN cord-320054-wqpr8v3p 75 30 was be VBD cord-320054-wqpr8v3p 75 31 dereased derease VBN cord-320054-wqpr8v3p 75 32 . . . cord-320054-wqpr8v3p 76 1 ( ( -LRB- cord-320054-wqpr8v3p 76 2 Table Table NNP cord-320054-wqpr8v3p 76 3 S9 S9 NNP cord-320054-wqpr8v3p 76 4 ) ) -RRB- cord-320054-wqpr8v3p 77 1 276 276 CD cord-320054-wqpr8v3p 78 1 The the DT cord-320054-wqpr8v3p 78 2 background background NN cord-320054-wqpr8v3p 78 3 of of IN cord-320054-wqpr8v3p 78 4 V615F V615F NNP cord-320054-wqpr8v3p 78 5 mutation mutation NN cord-320054-wqpr8v3p 78 6 is be VBZ cord-320054-wqpr8v3p 78 7 consistent consistent JJ cord-320054-wqpr8v3p 78 8 with with IN cord-320054-wqpr8v3p 78 9 V615I. V615I. NNP cord-320054-wqpr8v3p 78 10 Through through IN cord-320054-wqpr8v3p 78 11 the the DT cord-320054-wqpr8v3p 78 12 277 277 CD cord-320054-wqpr8v3p 78 13 above above RB cord-320054-wqpr8v3p 78 14 - - HYPH cord-320054-wqpr8v3p 78 15 mentioned mention VBN cord-320054-wqpr8v3p 78 16 forecasting forecasting NN cord-320054-wqpr8v3p 78 17 tool tool NN cord-320054-wqpr8v3p 78 18 , , , cord-320054-wqpr8v3p 78 19 we -PRON- PRP cord-320054-wqpr8v3p 78 20 found find VBD cord-320054-wqpr8v3p 78 21 that that IN cord-320054-wqpr8v3p 78 22 12 12 CD cord-320054-wqpr8v3p 78 23 alterations alteration NNS cord-320054-wqpr8v3p 78 24 directly directly RB cord-320054-wqpr8v3p 78 25 affected affect VBN cord-320054-wqpr8v3p 78 26 B b NN cord-320054-wqpr8v3p 78 27 cell cell NN cord-320054-wqpr8v3p 78 28 278 278 CD cord-320054-wqpr8v3p 78 29 epitope epitope NN cord-320054-wqpr8v3p 78 30 other other JJ cord-320054-wqpr8v3p 78 31 than than IN cord-320054-wqpr8v3p 78 32 V615I V615I NNP cord-320054-wqpr8v3p 78 33 mutation mutation NN cord-320054-wqpr8v3p 78 34 obviously obviously RB cord-320054-wqpr8v3p 78 35 ( ( -LRB- cord-320054-wqpr8v3p 78 36 Table Table NNP cord-320054-wqpr8v3p 78 37 S11 S11 NNP cord-320054-wqpr8v3p 78 38 ) ) -RRB- cord-320054-wqpr8v3p 78 39 298 298 CD cord-320054-wqpr8v3p 79 1 In in IN cord-320054-wqpr8v3p 79 2 order order NN cord-320054-wqpr8v3p 79 3 to to TO cord-320054-wqpr8v3p 79 4 investigate investigate VB cord-320054-wqpr8v3p 79 5 the the DT cord-320054-wqpr8v3p 79 6 influences influence NNS cord-320054-wqpr8v3p 79 7 of of IN cord-320054-wqpr8v3p 79 8 the the DT cord-320054-wqpr8v3p 79 9 above above JJ cord-320054-wqpr8v3p 79 10 common common JJ cord-320054-wqpr8v3p 79 11 9 9 CD cord-320054-wqpr8v3p 79 12 mutations mutation NNS cord-320054-wqpr8v3p 79 13 of of IN cord-320054-wqpr8v3p 79 14 299 299 CD cord-320054-wqpr8v3p 79 15 S s NN cord-320054-wqpr8v3p 79 16 protein protein NN cord-320054-wqpr8v3p 79 17 on on IN cord-320054-wqpr8v3p 79 18 B b NN cord-320054-wqpr8v3p 79 19 cell cell NN cord-320054-wqpr8v3p 79 20 epitopes epitope NNS cord-320054-wqpr8v3p 79 21 , , , cord-320054-wqpr8v3p 79 22 we -PRON- PRP cord-320054-wqpr8v3p 79 23 compared compare VBD cord-320054-wqpr8v3p 79 24 the the DT cord-320054-wqpr8v3p 79 25 predicted predict VBN cord-320054-wqpr8v3p 79 26 epitopes epitope NNS cord-320054-wqpr8v3p 79 27 of of IN cord-320054-wqpr8v3p 79 28 reference reference NN cord-320054-wqpr8v3p 79 29 and and CC cord-320054-wqpr8v3p 79 30 300 300 CD cord-320054-wqpr8v3p 79 31 mutant mutant NN cord-320054-wqpr8v3p 79 32 S S NNP cord-320054-wqpr8v3p 79 33 protein protein NN cord-320054-wqpr8v3p 79 34 , , , cord-320054-wqpr8v3p 79 35 analyzed analyze VBD cord-320054-wqpr8v3p 79 36 the the DT cord-320054-wqpr8v3p 79 37 association association NN cord-320054-wqpr8v3p 79 38 of of IN cord-320054-wqpr8v3p 79 39 epitope epitope NNP cord-320054-wqpr8v3p 79 40 changes change NNS cord-320054-wqpr8v3p 79 41 among among IN cord-320054-wqpr8v3p 79 42 mutations mutation NNS cord-320054-wqpr8v3p 79 43 and and CC cord-320054-wqpr8v3p 79 44 301 301 CD cord-320054-wqpr8v3p 79 45 determined determine VBD cord-320054-wqpr8v3p 79 46 the the DT cord-320054-wqpr8v3p 79 47 influence influence NN cord-320054-wqpr8v3p 79 48 of of IN cord-320054-wqpr8v3p 79 49 mutation mutation NN cord-320054-wqpr8v3p 79 50 on on IN cord-320054-wqpr8v3p 79 51 B b NN cord-320054-wqpr8v3p 79 52 cell cell NN cord-320054-wqpr8v3p 79 53 epitopes epitope NNS cord-320054-wqpr8v3p 79 54 . . . cord-320054-wqpr8v3p 80 1 The the DT cord-320054-wqpr8v3p 80 2 detailed detailed JJ cord-320054-wqpr8v3p 80 3 information information NN cord-320054-wqpr8v3p 80 4 of of IN cord-320054-wqpr8v3p 80 5 302 302 CD cord-320054-wqpr8v3p 80 6 changes change NNS cord-320054-wqpr8v3p 80 7 in in IN cord-320054-wqpr8v3p 80 8 each each DT cord-320054-wqpr8v3p 80 9 mutation mutation NN cord-320054-wqpr8v3p 80 10 is be VBZ cord-320054-wqpr8v3p 80 11 listed list VBN cord-320054-wqpr8v3p 80 12 in in IN cord-320054-wqpr8v3p 80 13 the the DT cord-320054-wqpr8v3p 80 14 Table Table NNP cord-320054-wqpr8v3p 80 15 S13 S13 NNP cord-320054-wqpr8v3p 80 16 . . . cord-320054-wqpr8v3p 81 1 We -PRON- PRP cord-320054-wqpr8v3p 81 2 found find VBD cord-320054-wqpr8v3p 81 3 that that IN cord-320054-wqpr8v3p 81 4 some some DT cord-320054-wqpr8v3p 81 5 mutations mutation NNS cord-320054-wqpr8v3p 81 6 did do VBD cord-320054-wqpr8v3p 81 7 303 303 CD cord-320054-wqpr8v3p 81 8 not not RB cord-320054-wqpr8v3p 81 9 or or CC cord-320054-wqpr8v3p 81 10 slightly slightly RB cord-320054-wqpr8v3p 81 11 change change NN cord-320054-wqpr8v3p 81 12 B b NN cord-320054-wqpr8v3p 81 13 - - HYPH cord-320054-wqpr8v3p 81 14 cell cell NN cord-320054-wqpr8v3p 81 15 epitopes epitope NNS cord-320054-wqpr8v3p 81 16 , , , cord-320054-wqpr8v3p 81 17 while while IN cord-320054-wqpr8v3p 81 18 others other NNS cord-320054-wqpr8v3p 81 19 strongly strongly RB cord-320054-wqpr8v3p 81 20 impact impact VBP cord-320054-wqpr8v3p 81 21 the the DT cord-320054-wqpr8v3p 81 22 number number NN cord-320054-wqpr8v3p 81 23 and and CC cord-320054-wqpr8v3p 81 24 site site NN cord-320054-wqpr8v3p 81 25 304 304 CD cord-320054-wqpr8v3p 81 26 of of IN cord-320054-wqpr8v3p 81 27 B b NN cord-320054-wqpr8v3p 81 28 - - HYPH cord-320054-wqpr8v3p 81 29 cell cell NN cord-320054-wqpr8v3p 81 30 epitopes epitope NNS cord-320054-wqpr8v3p 81 31 . . . cord-320054-wqpr8v3p 82 1 All all PDT cord-320054-wqpr8v3p 82 2 the the DT cord-320054-wqpr8v3p 82 3 major major JJ cord-320054-wqpr8v3p 82 4 changes change NNS cord-320054-wqpr8v3p 82 5 of of IN cord-320054-wqpr8v3p 82 6 B b NN cord-320054-wqpr8v3p 82 7 - - HYPH cord-320054-wqpr8v3p 82 8 cells cell NNS cord-320054-wqpr8v3p 82 9 comparison comparison NN cord-320054-wqpr8v3p 82 10 was be VBD cord-320054-wqpr8v3p 82 11 summarized summarize VBN cord-320054-wqpr8v3p 82 12 in in IN cord-320054-wqpr8v3p 82 13 305 305 CD cord-320054-wqpr8v3p 82 14 Table Table NNP cord-320054-wqpr8v3p 82 15 5 5 CD cord-320054-wqpr8v3p 82 16 . . . cord-320054-wqpr8v3p 83 1 Most most RBS cord-320054-wqpr8v3p 83 2 important important JJ cord-320054-wqpr8v3p 83 3 finding finding NN cord-320054-wqpr8v3p 83 4 is be VBZ cord-320054-wqpr8v3p 83 5 that that IN cord-320054-wqpr8v3p 83 6 the the DT cord-320054-wqpr8v3p 83 7 commonest common JJS cord-320054-wqpr8v3p 83 8 mutation mutation NN cord-320054-wqpr8v3p 83 9 D614 d614 CD cord-320054-wqpr8v3p 83 10 G g NN cord-320054-wqpr8v3p 83 11 change change NN cord-320054-wqpr8v3p 83 12 the the DT cord-320054-wqpr8v3p 83 13 306 306 CD cord-320054-wqpr8v3p 83 14 B b NN cord-320054-wqpr8v3p 83 15 - - HYPH cord-320054-wqpr8v3p 83 16 cell cell NN cord-320054-wqpr8v3p 83 17 epitopes epitope NNS cord-320054-wqpr8v3p 83 18 of of IN cord-320054-wqpr8v3p 83 19 S S NNP cord-320054-wqpr8v3p 83 20 protein protein NN cord-320054-wqpr8v3p 83 21 slightly slightly RB cord-320054-wqpr8v3p 83 22 , , , cord-320054-wqpr8v3p 83 23 only only RB cord-320054-wqpr8v3p 83 24 moderately moderately RB cord-320054-wqpr8v3p 83 25 increasing increase VBG cord-320054-wqpr8v3p 83 26 the the DT cord-320054-wqpr8v3p 83 27 accessibility accessibility NN cord-320054-wqpr8v3p 83 28 and and CC cord-320054-wqpr8v3p 83 29 307 307 CD cord-320054-wqpr8v3p 83 30 antigenicity antigenicity NN cord-320054-wqpr8v3p 83 31 of of IN cord-320054-wqpr8v3p 83 32 epitope epitope NN cord-320054-wqpr8v3p 83 33 657 657 CD cord-320054-wqpr8v3p 83 34 - - HYPH cord-320054-wqpr8v3p 83 35 663 663 CD cord-320054-wqpr8v3p 83 36 . . . cord-320054-wqpr8v3p 84 1 There there EX cord-320054-wqpr8v3p 84 2 are be VBP cord-320054-wqpr8v3p 84 3 12 12 CD cord-320054-wqpr8v3p 84 4 potential potential JJ cord-320054-wqpr8v3p 84 5 epitopes epitope NNS cord-320054-wqpr8v3p 84 6 in in IN cord-320054-wqpr8v3p 84 7 D614 d614 NN cord-320054-wqpr8v3p 84 8 G G NNP cord-320054-wqpr8v3p 84 9 308 308 CD cord-320054-wqpr8v3p 84 10 mutation mutation NN cord-320054-wqpr8v3p 84 11 , , , cord-320054-wqpr8v3p 84 12 nearly nearly RB cord-320054-wqpr8v3p 84 13 identical identical JJ cord-320054-wqpr8v3p 84 14 to to IN cord-320054-wqpr8v3p 84 15 those those DT cord-320054-wqpr8v3p 84 16 without without IN cord-320054-wqpr8v3p 84 17 mutation mutation NN cord-320054-wqpr8v3p 84 18 . . . cord-320054-wqpr8v3p 85 1 In in IN cord-320054-wqpr8v3p 85 2 D614 d614 NN cord-320054-wqpr8v3p 85 3 G g NN cord-320054-wqpr8v3p 85 4 and and CC cord-320054-wqpr8v3p 85 5 V615I V615I NNP cord-320054-wqpr8v3p 85 6 309 309 CD cord-320054-wqpr8v3p 85 7 mutation mutation NN cord-320054-wqpr8v3p 85 8 , , , cord-320054-wqpr8v3p 85 9 their -PRON- PRP$ cord-320054-wqpr8v3p 85 10 effective effective JJ cord-320054-wqpr8v3p 85 11 epitopes epitope NNS cord-320054-wqpr8v3p 85 12 were be VBD cord-320054-wqpr8v3p 85 13 also also RB cord-320054-wqpr8v3p 85 14 12 12 CD cord-320054-wqpr8v3p 85 15 , , , cord-320054-wqpr8v3p 85 16 in in IN cord-320054-wqpr8v3p 85 17 which which WDT cord-320054-wqpr8v3p 85 18 only only RB cord-320054-wqpr8v3p 85 19 1 1 CD cord-320054-wqpr8v3p 85 20 epitope epitope NN cord-320054-wqpr8v3p 85 21 at at IN cord-320054-wqpr8v3p 85 22 the the DT cord-320054-wqpr8v3p 85 23 same same JJ cord-320054-wqpr8v3p 85 24 site site NN cord-320054-wqpr8v3p 85 25 Table table NN cord-320054-wqpr8v3p 85 26 1 1 CD cord-320054-wqpr8v3p 85 27 , , , cord-320054-wqpr8v3p 85 28 and and CC cord-320054-wqpr8v3p 85 29 5 5 CD cord-320054-wqpr8v3p 85 30 of of IN cord-320054-wqpr8v3p 85 31 them -PRON- PRP cord-320054-wqpr8v3p 85 32 are be VBP cord-320054-wqpr8v3p 85 33 concentrated concentrate VBN cord-320054-wqpr8v3p 85 34 on on IN cord-320054-wqpr8v3p 85 35 and and CC cord-320054-wqpr8v3p 85 36 near near IN cord-320054-wqpr8v3p 85 37 330 330 CD cord-320054-wqpr8v3p 85 38 RBD RBD NNP cord-320054-wqpr8v3p 85 39 domain domain NN cord-320054-wqpr8v3p 85 40 . . . cord-320054-wqpr8v3p 86 1 Especially especially RB cord-320054-wqpr8v3p 86 2 , , , cord-320054-wqpr8v3p 86 3 the the DT cord-320054-wqpr8v3p 86 4 most most RBS cord-320054-wqpr8v3p 86 5 frequently frequently RB cord-320054-wqpr8v3p 86 6 occurring occur VBG cord-320054-wqpr8v3p 86 7 mutation mutation NN cord-320054-wqpr8v3p 86 8 D614 d614 CD cord-320054-wqpr8v3p 86 9 G g NN cord-320054-wqpr8v3p 86 10 located locate VBN cord-320054-wqpr8v3p 86 11 at at IN cord-320054-wqpr8v3p 86 12 S1 S1 NNP cord-320054-wqpr8v3p 86 13 331 331 CD cord-320054-wqpr8v3p 86 14 and and CC cord-320054-wqpr8v3p 86 15 S2 s2 NN cord-320054-wqpr8v3p 86 16 junctions junction NNS cord-320054-wqpr8v3p 86 17 , , , cord-320054-wqpr8v3p 86 18 where where WRB cord-320054-wqpr8v3p 86 19 is be VBZ cord-320054-wqpr8v3p 86 20 near near IN cord-320054-wqpr8v3p 86 21 the the DT cord-320054-wqpr8v3p 86 22 furin furin NN cord-320054-wqpr8v3p 86 23 cleavage cleavage NN cord-320054-wqpr8v3p 86 24 site site NN cord-320054-wqpr8v3p 86 25 of of IN cord-320054-wqpr8v3p 86 26 the the DT cord-320054-wqpr8v3p 86 27 S1 S1 NNP cord-320054-wqpr8v3p 86 28 / / SYM cord-320054-wqpr8v3p 86 29 S2 S2 NNP cord-320054-wqpr8v3p 86 30 boundary boundary NN cord-320054-wqpr8v3p 86 31 . . . cord-320054-wqpr8v3p 87 1 Walls wall NNS cord-320054-wqpr8v3p 87 2 332 332 CD cord-320054-wqpr8v3p 87 3 reported report VBD cord-320054-wqpr8v3p 87 4 that that IN cord-320054-wqpr8v3p 87 5 deletion deletion NN cord-320054-wqpr8v3p 87 6 of of IN cord-320054-wqpr8v3p 87 7 this this DT cord-320054-wqpr8v3p 87 8 cleavage cleavage NN cord-320054-wqpr8v3p 87 9 region region NN cord-320054-wqpr8v3p 87 10 could could MD cord-320054-wqpr8v3p 87 11 influence influence VB cord-320054-wqpr8v3p 87 12 SARS SARS NNP cord-320054-wqpr8v3p 87 13 - - HYPH cord-320054-wqpr8v3p 87 14 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 87 15 S S NNP cord-320054-wqpr8v3p 87 16 - - HYPH cord-320054-wqpr8v3p 87 17 mediated mediate VBN cord-320054-wqpr8v3p 87 18 333 333 CD cord-320054-wqpr8v3p 87 19 entry entry NN cord-320054-wqpr8v3p 87 20 into into IN cord-320054-wqpr8v3p 87 21 host host NN cord-320054-wqpr8v3p 87 22 cells cell NNS cord-320054-wqpr8v3p 87 23 [ [ -LRB- cord-320054-wqpr8v3p 87 24 8 8 CD cord-320054-wqpr8v3p 87 25 ] ] -RRB- cord-320054-wqpr8v3p 87 26 . . . cord-320054-wqpr8v3p 88 1 Hence hence RB cord-320054-wqpr8v3p 88 2 , , , cord-320054-wqpr8v3p 88 3 Korber Korber NNP cord-320054-wqpr8v3p 88 4 [ [ -LRB- cord-320054-wqpr8v3p 88 5 12 12 CD cord-320054-wqpr8v3p 88 6 ] ] -RRB- cord-320054-wqpr8v3p 88 7 and and CC cord-320054-wqpr8v3p 88 8 Zhang Zhang NNP cord-320054-wqpr8v3p 88 9 [ [ -LRB- cord-320054-wqpr8v3p 88 10 19 19 CD cord-320054-wqpr8v3p 88 11 ] ] -RRB- cord-320054-wqpr8v3p 88 12 proposed propose VBD cord-320054-wqpr8v3p 88 13 that that IN cord-320054-wqpr8v3p 88 14 D614 d614 NN cord-320054-wqpr8v3p 88 15 G g NN cord-320054-wqpr8v3p 88 16 334 334 CD cord-320054-wqpr8v3p 88 17 mutation mutation NN cord-320054-wqpr8v3p 88 18 contributes contribute VBZ cord-320054-wqpr8v3p 88 19 to to IN cord-320054-wqpr8v3p 88 20 the the DT cord-320054-wqpr8v3p 88 21 spread spread NN cord-320054-wqpr8v3p 88 22 of of IN cord-320054-wqpr8v3p 88 23 SARS SARS NNP cord-320054-wqpr8v3p 88 24 - - HYPH cord-320054-wqpr8v3p 88 25 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 88 26 , , , cord-320054-wqpr8v3p 88 27 which which WDT cord-320054-wqpr8v3p 88 28 makes make VBZ cord-320054-wqpr8v3p 88 29 G614 G614 `` cord-320054-wqpr8v3p 88 30 strain strain VB cord-320054-wqpr8v3p 88 31 swiftly swiftly RB cord-320054-wqpr8v3p 88 32 335 335 CD cord-320054-wqpr8v3p 88 33 become become VBP cord-320054-wqpr8v3p 88 34 the the DT cord-320054-wqpr8v3p 88 35 dominant dominant JJ cord-320054-wqpr8v3p 88 36 mutant mutant NN cord-320054-wqpr8v3p 88 37 . . . cord-320054-wqpr8v3p 89 1 336 336 CD cord-320054-wqpr8v3p 90 1 The the DT cord-320054-wqpr8v3p 90 2 mutation mutation NN cord-320054-wqpr8v3p 90 3 in in IN cord-320054-wqpr8v3p 90 4 S s NN cord-320054-wqpr8v3p 90 5 protein protein NN cord-320054-wqpr8v3p 90 6 may may MD cord-320054-wqpr8v3p 90 7 affect affect VB cord-320054-wqpr8v3p 90 8 the the DT cord-320054-wqpr8v3p 90 9 B b NN cord-320054-wqpr8v3p 90 10 - - HYPH cord-320054-wqpr8v3p 90 11 cell cell NN cord-320054-wqpr8v3p 90 12 epitopes epitope NNS cord-320054-wqpr8v3p 90 13 and and CC cord-320054-wqpr8v3p 90 14 lead lead NN cord-320054-wqpr8v3p 90 15 to to IN cord-320054-wqpr8v3p 90 16 vaccine vaccine NN cord-320054-wqpr8v3p 90 17 337 337 CD cord-320054-wqpr8v3p 90 18 failure failure NN cord-320054-wqpr8v3p 90 19 . . . cord-320054-wqpr8v3p 91 1 Therefore therefore RB cord-320054-wqpr8v3p 91 2 , , , cord-320054-wqpr8v3p 91 3 in in IN cord-320054-wqpr8v3p 91 4 order order NN cord-320054-wqpr8v3p 91 5 to to TO cord-320054-wqpr8v3p 91 6 explore explore VB cord-320054-wqpr8v3p 91 7 the the DT cord-320054-wqpr8v3p 91 8 impact impact NN cord-320054-wqpr8v3p 91 9 of of IN cord-320054-wqpr8v3p 91 10 mutations mutation NNS cord-320054-wqpr8v3p 91 11 on on IN cord-320054-wqpr8v3p 91 12 antigenicity antigenicity NN cord-320054-wqpr8v3p 91 13 of of IN cord-320054-wqpr8v3p 91 14 S S NNP cord-320054-wqpr8v3p 91 15 338 338 CD cord-320054-wqpr8v3p 91 16 protein protein NN cord-320054-wqpr8v3p 91 17 , , , cord-320054-wqpr8v3p 91 18 in in IN cord-320054-wqpr8v3p 91 19 this this DT cord-320054-wqpr8v3p 91 20 study study NN cord-320054-wqpr8v3p 91 21 , , , cord-320054-wqpr8v3p 91 22 we -PRON- PRP cord-320054-wqpr8v3p 91 23 applied apply VBD cord-320054-wqpr8v3p 91 24 immuno immuno JJ cord-320054-wqpr8v3p 91 25 - - HYPH cord-320054-wqpr8v3p 91 26 informatics informatics NN cord-320054-wqpr8v3p 91 27 tools tool NNS cord-320054-wqpr8v3p 91 28 to to TO cord-320054-wqpr8v3p 91 29 predict predict VB cord-320054-wqpr8v3p 91 30 potential potential JJ cord-320054-wqpr8v3p 91 31 B b NN cord-320054-wqpr8v3p 91 32 - - HYPH cord-320054-wqpr8v3p 91 33 cell cell NN cord-320054-wqpr8v3p 91 34 339 339 CD cord-320054-wqpr8v3p 91 35 epitopes epitope NNS cord-320054-wqpr8v3p 91 36 of of IN cord-320054-wqpr8v3p 91 37 prototype prototype NN cord-320054-wqpr8v3p 91 38 and and CC cord-320054-wqpr8v3p 91 39 variant variant NN cord-320054-wqpr8v3p 91 40 S S NNP cord-320054-wqpr8v3p 91 41 protein protein NN cord-320054-wqpr8v3p 91 42 . . . cord-320054-wqpr8v3p 92 1 ( ( -LRB- cord-320054-wqpr8v3p 92 2 Table table NN cord-320054-wqpr8v3p 92 3 2 2 CD cord-320054-wqpr8v3p 92 4 ) ) -RRB- cord-320054-wqpr8v3p 92 5 and and CC cord-320054-wqpr8v3p 92 6 discontinuous discontinuous JJ cord-320054-wqpr8v3p 92 7 epitopes epitope NNS cord-320054-wqpr8v3p 93 1 such such JJ cord-320054-wqpr8v3p 93 2 357 357 CD cord-320054-wqpr8v3p 93 3 as as IN cord-320054-wqpr8v3p 93 4 No.2 No.2 NNP cord-320054-wqpr8v3p 94 1 ( ( -LRB- cord-320054-wqpr8v3p 94 2 Table table NN cord-320054-wqpr8v3p 94 3 3 3 CD cord-320054-wqpr8v3p 94 4 ) ) -RRB- cord-320054-wqpr8v3p 94 5 could could MD cord-320054-wqpr8v3p 94 6 be be VB cord-320054-wqpr8v3p 94 7 vaccine vaccine NN cord-320054-wqpr8v3p 94 8 candidates candidate NNS cord-320054-wqpr8v3p 94 9 targets target NNS cord-320054-wqpr8v3p 94 10 . . . cord-320054-wqpr8v3p 95 1 358 358 CD cord-320054-wqpr8v3p 96 1 Importantly importantly RB cord-320054-wqpr8v3p 96 2 , , , cord-320054-wqpr8v3p 96 3 it -PRON- PRP cord-320054-wqpr8v3p 96 4 's be VBZ cord-320054-wqpr8v3p 96 5 worth worth JJ cord-320054-wqpr8v3p 96 6 exploring explore VBG cord-320054-wqpr8v3p 96 7 whether whether IN cord-320054-wqpr8v3p 96 8 or or CC cord-320054-wqpr8v3p 96 9 not not RB cord-320054-wqpr8v3p 96 10 the the DT cord-320054-wqpr8v3p 96 11 mutations mutation NNS cord-320054-wqpr8v3p 96 12 on on IN cord-320054-wqpr8v3p 96 13 S s NN cord-320054-wqpr8v3p 96 14 protein protein NN cord-320054-wqpr8v3p 96 15 leads lead VBZ cord-320054-wqpr8v3p 96 16 359 359 CD cord-320054-wqpr8v3p 96 17 to to IN cord-320054-wqpr8v3p 96 18 epitope epitope NN cord-320054-wqpr8v3p 96 19 changes change NNS cord-320054-wqpr8v3p 96 20 . . . cord-320054-wqpr8v3p 97 1 Therefore therefore RB cord-320054-wqpr8v3p 97 2 , , , cord-320054-wqpr8v3p 97 3 we -PRON- PRP cord-320054-wqpr8v3p 97 4 used use VBD cord-320054-wqpr8v3p 97 5 a a DT cord-320054-wqpr8v3p 97 6 group group NN cord-320054-wqpr8v3p 97 7 of of IN cord-320054-wqpr8v3p 97 8 prediction prediction NN cord-320054-wqpr8v3p 97 9 tools tool NNS cord-320054-wqpr8v3p 97 10 of of IN cord-320054-wqpr8v3p 97 11 B b NN cord-320054-wqpr8v3p 97 12 - - HYPH cord-320054-wqpr8v3p 97 13 cell cell NN cord-320054-wqpr8v3p 97 14 epitopes epitope NNS cord-320054-wqpr8v3p 97 15 to to IN cord-320054-wqpr8v3p 97 16 360 360 CD cord-320054-wqpr8v3p 97 17 predict predict VBP cord-320054-wqpr8v3p 97 18 the the DT cord-320054-wqpr8v3p 97 19 prototype prototype NN cord-320054-wqpr8v3p 97 20 and and CC cord-320054-wqpr8v3p 97 21 variant variant NN cord-320054-wqpr8v3p 97 22 S S NNP cord-320054-wqpr8v3p 97 23 protein protein NN cord-320054-wqpr8v3p 97 24 . . . cord-320054-wqpr8v3p 98 1 The the DT cord-320054-wqpr8v3p 98 2 primary primary JJ cord-320054-wqpr8v3p 98 3 sequence sequence NN cord-320054-wqpr8v3p 98 4 of of IN cord-320054-wqpr8v3p 98 5 SARS SARS NNP cord-320054-wqpr8v3p 98 6 - - HYPH cord-320054-wqpr8v3p 98 7 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 98 8 S S NNP cord-320054-wqpr8v3p 98 9 protein protein NN cord-320054-wqpr8v3p 98 10 was be VBD cord-320054-wqpr8v3p 98 11 retrieved retrieve VBN cord-320054-wqpr8v3p 98 12 from from IN cord-320054-wqpr8v3p 98 13 NCBI NCBI NNP cord-320054-wqpr8v3p 98 14 GenBank GenBank NNP cord-320054-wqpr8v3p 98 15 406 406 CD cord-320054-wqpr8v3p 98 16 database database NN cord-320054-wqpr8v3p 98 17 using use VBG cord-320054-wqpr8v3p 98 18 accession accession NN cord-320054-wqpr8v3p 98 19 number number NN cord-320054-wqpr8v3p 98 20 QHO62107.1 QHO62107.1 NNP cord-320054-wqpr8v3p 98 21 and and CC cord-320054-wqpr8v3p 98 22 was be VBD cord-320054-wqpr8v3p 98 23 used use VBN cord-320054-wqpr8v3p 98 24 as as IN cord-320054-wqpr8v3p 98 25 prototype prototype NN cord-320054-wqpr8v3p 98 26 sequence sequence NN cord-320054-wqpr8v3p 98 27 or or CC cord-320054-wqpr8v3p 98 28 407 407 CD cord-320054-wqpr8v3p 98 29 reference reference NN cord-320054-wqpr8v3p 98 30 sequence sequence NN cord-320054-wqpr8v3p 98 31 for for IN cord-320054-wqpr8v3p 98 32 vaccine vaccine NN cord-320054-wqpr8v3p 98 33 development development NN cord-320054-wqpr8v3p 98 34 in in IN cord-320054-wqpr8v3p 98 35 many many JJ cord-320054-wqpr8v3p 98 36 projects project NNS cord-320054-wqpr8v3p 98 37 [ [ -LRB- cord-320054-wqpr8v3p 98 38 14 14 CD cord-320054-wqpr8v3p 98 39 ] ] -RRB- cord-320054-wqpr8v3p 98 40 . . . cord-320054-wqpr8v3p 99 1 Its -PRON- PRP$ cord-320054-wqpr8v3p 99 2 complete complete JJ cord-320054-wqpr8v3p 99 3 408 408 CD cord-320054-wqpr8v3p 99 4 genome genome NN cord-320054-wqpr8v3p 99 5 number number NN cord-320054-wqpr8v3p 99 6 is be VBZ cord-320054-wqpr8v3p 99 7 NC_045512 NC_045512 NNP cord-320054-wqpr8v3p 99 8 , , , cord-320054-wqpr8v3p 99 9 which which WDT cord-320054-wqpr8v3p 99 10 . . . cord-320054-wqpr8v3p 100 1 The the DT cord-320054-wqpr8v3p 100 2 major major JJ cord-320054-wqpr8v3p 100 3 variation variation NN cord-320054-wqpr8v3p 100 4 sequences sequence NNS cord-320054-wqpr8v3p 100 5 were be VBD cord-320054-wqpr8v3p 100 6 available available JJ cord-320054-wqpr8v3p 100 7 409 409 CD cord-320054-wqpr8v3p 100 8 from from IN cord-320054-wqpr8v3p 100 9 The the DT cord-320054-wqpr8v3p 100 10 Global Global NNP cord-320054-wqpr8v3p 100 11 Initiative Initiative NNP cord-320054-wqpr8v3p 100 12 for for IN cord-320054-wqpr8v3p 100 13 Sharing share VBG cord-320054-wqpr8v3p 100 14 All all DT cord-320054-wqpr8v3p 100 15 Influenza Influenza NNP cord-320054-wqpr8v3p 100 16 Data Data NNP cord-320054-wqpr8v3p 100 17 ( ( -LRB- cord-320054-wqpr8v3p 100 18 GISAID GISAID NNP cord-320054-wqpr8v3p 100 19 ) ) -RRB- cord-320054-wqpr8v3p 101 1 [ [ -LRB- cord-320054-wqpr8v3p 101 2 26 26 CD cord-320054-wqpr8v3p 101 3 ] ] -RRB- cord-320054-wqpr8v3p 101 4 and and CC cord-320054-wqpr8v3p 101 5 GenBank GenBank NNP cord-320054-wqpr8v3p 101 6 446 446 CD cord-320054-wqpr8v3p 102 1 We -PRON- PRP cord-320054-wqpr8v3p 102 2 used use VBD cord-320054-wqpr8v3p 102 3 the the DT cord-320054-wqpr8v3p 102 4 sequence sequence NN cord-320054-wqpr8v3p 102 5 from from IN cord-320054-wqpr8v3p 102 6 early early JJ cord-320054-wqpr8v3p 102 7 onset onset NN cord-320054-wqpr8v3p 102 8 SARS SARS NNP cord-320054-wqpr8v3p 102 9 - - HYPH cord-320054-wqpr8v3p 102 10 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 102 11 as as IN cord-320054-wqpr8v3p 102 12 the the DT cord-320054-wqpr8v3p 102 13 wildtype wildtype NN cord-320054-wqpr8v3p 102 14 or or CC cord-320054-wqpr8v3p 102 15 prototype prototype NN cord-320054-wqpr8v3p 102 16 and and CC cord-320054-wqpr8v3p 102 17 447 447 CD cord-320054-wqpr8v3p 102 18 the the DT cord-320054-wqpr8v3p 102 19 recent recent JJ cord-320054-wqpr8v3p 102 20 variant variant JJ cord-320054-wqpr8v3p 102 21 virus virus NN cord-320054-wqpr8v3p 102 22 as as IN cord-320054-wqpr8v3p 102 23 mutation mutation NN cord-320054-wqpr8v3p 102 24 strains strain NNS cord-320054-wqpr8v3p 102 25 to to TO cord-320054-wqpr8v3p 102 26 predict predict VB cord-320054-wqpr8v3p 102 27 the the DT cord-320054-wqpr8v3p 102 28 B b NN cord-320054-wqpr8v3p 102 29 - - HYPH cord-320054-wqpr8v3p 102 30 cell cell NN cord-320054-wqpr8v3p 102 31 epitopes epitope NNS cord-320054-wqpr8v3p 102 32 of of IN cord-320054-wqpr8v3p 102 33 S S NNP cord-320054-wqpr8v3p 102 34 protein protein NN cord-320054-wqpr8v3p 102 35 . . . cord-320054-wqpr8v3p 103 1 22 22 CD cord-320054-wqpr8v3p 103 2 _SP cord-320054-wqpr8v3p 104 1 The the DT cord-320054-wqpr8v3p 104 2 S S NNP cord-320054-wqpr8v3p 104 3 protein protein NN cord-320054-wqpr8v3p 104 4 sequence sequence NN cord-320054-wqpr8v3p 104 5 was be VBD cord-320054-wqpr8v3p 104 6 exclusive exclusive JJ cord-320054-wqpr8v3p 104 7 of of IN cord-320054-wqpr8v3p 104 8 the the DT cord-320054-wqpr8v3p 104 9 signal signal NN cord-320054-wqpr8v3p 104 10 peptide peptide NN cord-320054-wqpr8v3p 104 11 ( ( -LRB- cord-320054-wqpr8v3p 104 12 SP SP NNP cord-320054-wqpr8v3p 104 13 ) ) -RRB- cord-320054-wqpr8v3p 104 14 , , , cord-320054-wqpr8v3p 104 15 TM TM NNP cord-320054-wqpr8v3p 104 16 and and CC cord-320054-wqpr8v3p 104 17 cytoplasmic cytoplasmic JJ cord-320054-wqpr8v3p 104 18 449 449 CD cord-320054-wqpr8v3p 104 19 region region NN cord-320054-wqpr8v3p 104 20 , , , cord-320054-wqpr8v3p 104 21 and and CC cord-320054-wqpr8v3p 104 22 only only RB cord-320054-wqpr8v3p 104 23 the the DT cord-320054-wqpr8v3p 104 24 ectodomain ectodomain NN cord-320054-wqpr8v3p 104 25 of of IN cord-320054-wqpr8v3p 104 26 S S NNP cord-320054-wqpr8v3p 104 27 protein protein NN cord-320054-wqpr8v3p 104 28 was be VBD cord-320054-wqpr8v3p 104 29 used use VBN cord-320054-wqpr8v3p 104 30 for for IN cord-320054-wqpr8v3p 104 31 analysis analysis NN cord-320054-wqpr8v3p 104 32 . . . cord-320054-wqpr8v3p 105 1 The the DT cord-320054-wqpr8v3p 105 2 linear linear NN cord-320054-wqpr8v3p 105 3 and and CC cord-320054-wqpr8v3p 105 4 450 450 CD cord-320054-wqpr8v3p 105 5 non non JJ cord-320054-wqpr8v3p 105 6 - - JJ cord-320054-wqpr8v3p 105 7 linear linear JJ cord-320054-wqpr8v3p 105 8 ( ( -LRB- cord-320054-wqpr8v3p 105 9 discontinuous discontinuous JJ cord-320054-wqpr8v3p 105 10 ) ) -RRB- cord-320054-wqpr8v3p 105 11 epitopes epitope NNS cord-320054-wqpr8v3p 105 12 of of IN cord-320054-wqpr8v3p 105 13 B B NNP cord-320054-wqpr8v3p 105 14 cell cell NN cord-320054-wqpr8v3p 105 15 were be VBD cord-320054-wqpr8v3p 105 16 predicted predict VBN cord-320054-wqpr8v3p 105 17 by by IN cord-320054-wqpr8v3p 105 18 the the DT cord-320054-wqpr8v3p 105 19 different different JJ cord-320054-wqpr8v3p 105 20 tools tool NNS cord-320054-wqpr8v3p 105 21 . . . cord-320054-wqpr8v3p 106 1 451 451 CD cord-320054-wqpr8v3p 107 1 The the DT cord-320054-wqpr8v3p 107 2 linear linear JJ cord-320054-wqpr8v3p 107 3 epitopes epitope NNS cord-320054-wqpr8v3p 107 4 were be VBD cord-320054-wqpr8v3p 107 5 prediced predice VBN cord-320054-wqpr8v3p 107 6 by by IN cord-320054-wqpr8v3p 107 7 BepiPred-2.0 BepiPred-2.0 NNP cord-320054-wqpr8v3p 107 8 server server NN cord-320054-wqpr8v3p 107 9 of of IN cord-320054-wqpr8v3p 107 10 IEDB IEDB NNP cord-320054-wqpr8v3p 107 11 online online JJ cord-320054-wqpr8v3p 107 12 database database NN cord-320054-wqpr8v3p 107 13 [ [ -LRB- cord-320054-wqpr8v3p 107 14 33 33 CD cord-320054-wqpr8v3p 107 15 , , , cord-320054-wqpr8v3p 107 16 452 452 CD cord-320054-wqpr8v3p 107 17 34 34 CD cord-320054-wqpr8v3p 107 18 ] ] -RRB- cord-320054-wqpr8v3p 107 19 . . . cord-320054-wqpr8v3p 108 1 The the DT cord-320054-wqpr8v3p 108 2 threshold threshold NN cord-320054-wqpr8v3p 108 3 was be VBD cord-320054-wqpr8v3p 108 4 set set VBN cord-320054-wqpr8v3p 108 5 to to IN cord-320054-wqpr8v3p 108 6 0.55 0.55 CD cord-320054-wqpr8v3p 108 7 , , , cord-320054-wqpr8v3p 108 8 which which WDT cord-320054-wqpr8v3p 108 9 represented represent VBD cord-320054-wqpr8v3p 108 10 that that IN cord-320054-wqpr8v3p 108 11 the the DT cord-320054-wqpr8v3p 108 12 sensitivity sensitivity NN cord-320054-wqpr8v3p 108 13 was be VBD cord-320054-wqpr8v3p 108 14 29 29 CD cord-320054-wqpr8v3p 108 15 % % NN cord-320054-wqpr8v3p 108 16 , , , cord-320054-wqpr8v3p 108 17 and and CC cord-320054-wqpr8v3p 108 18 453 453 CD cord-320054-wqpr8v3p 108 19 the the DT cord-320054-wqpr8v3p 108 20 specificity specificity NN cord-320054-wqpr8v3p 108 21 was be VBD cord-320054-wqpr8v3p 108 22 81 81 CD cord-320054-wqpr8v3p 108 23 % % NN cord-320054-wqpr8v3p 108 24 . . . cord-320054-wqpr8v3p 109 1 Analysis analysis NN cord-320054-wqpr8v3p 109 2 result result NN cord-320054-wqpr8v3p 109 3 shows show VBZ cord-320054-wqpr8v3p 109 4 in in IN cord-320054-wqpr8v3p 109 5 a a DT cord-320054-wqpr8v3p 109 6 figure figure NN cord-320054-wqpr8v3p 109 7 in in IN cord-320054-wqpr8v3p 109 8 which which WDT cord-320054-wqpr8v3p 109 9 the the DT cord-320054-wqpr8v3p 109 10 residues residue NNS cord-320054-wqpr8v3p 109 11 with with IN cord-320054-wqpr8v3p 109 12 454 454 CD cord-320054-wqpr8v3p 109 13 scores score NNS cord-320054-wqpr8v3p 109 14 above above IN cord-320054-wqpr8v3p 109 15 the the DT cord-320054-wqpr8v3p 109 16 threshold threshold NN cord-320054-wqpr8v3p 109 17 predicted predict VBN cord-320054-wqpr8v3p 109 18 to to TO cord-320054-wqpr8v3p 109 19 be be VB cord-320054-wqpr8v3p 109 20 part part NN cord-320054-wqpr8v3p 109 21 of of IN cord-320054-wqpr8v3p 109 22 an an DT cord-320054-wqpr8v3p 109 23 epitope epitope NN cord-320054-wqpr8v3p 109 24 were be VBD cord-320054-wqpr8v3p 109 25 colored color VBN cord-320054-wqpr8v3p 109 26 in in IN cord-320054-wqpr8v3p 109 27 yellow yellow JJ cord-320054-wqpr8v3p 109 28 . . . cord-320054-wqpr8v3p 110 1 455 455 CD cord-320054-wqpr8v3p 111 1 The the DT cord-320054-wqpr8v3p 111 2 effective effective JJ cord-320054-wqpr8v3p 111 3 B b NN cord-320054-wqpr8v3p 111 4 - - HYPH cord-320054-wqpr8v3p 111 5 cell cell NN cord-320054-wqpr8v3p 111 6 epitopes epitope NNS cord-320054-wqpr8v3p 111 7 relies rely VBZ cord-320054-wqpr8v3p 111 8 on on IN cord-320054-wqpr8v3p 111 9 stronger strong JJR cord-320054-wqpr8v3p 111 10 antigenicity antigenicity NN cord-320054-wqpr8v3p 111 11 and and CC cord-320054-wqpr8v3p 111 12 accessibility accessibility NN cord-320054-wqpr8v3p 111 13 of of IN cord-320054-wqpr8v3p 111 14 surface surface NN cord-320054-wqpr8v3p 111 15 _SP cord-320054-wqpr8v3p 111 16 A a DT cord-320054-wqpr8v3p 111 17 pneumonia pneumonia NN cord-320054-wqpr8v3p 111 18 outbreak outbreak NN cord-320054-wqpr8v3p 111 19 associated associate VBD cord-320054-wqpr8v3p 111 20 490 490 CD cord-320054-wqpr8v3p 111 21 with with IN cord-320054-wqpr8v3p 111 22 a a DT cord-320054-wqpr8v3p 111 23 new new JJ cord-320054-wqpr8v3p 111 24 coronavirus coronavirus NN cord-320054-wqpr8v3p 111 25 of of IN cord-320054-wqpr8v3p 111 26 probable probable JJ cord-320054-wqpr8v3p 111 27 bat bat NN cord-320054-wqpr8v3p 111 28 origin origin NN cord-320054-wqpr8v3p 111 29 Identification identification NN cord-320054-wqpr8v3p 111 30 of of IN cord-320054-wqpr8v3p 111 31 a a DT cord-320054-wqpr8v3p 111 32 492 492 CD cord-320054-wqpr8v3p 111 33 novel novel JJ cord-320054-wqpr8v3p 111 34 coronavirus coronavirus NN cord-320054-wqpr8v3p 111 35 in in IN cord-320054-wqpr8v3p 111 36 patients patient NNS cord-320054-wqpr8v3p 111 37 with with IN cord-320054-wqpr8v3p 111 38 severe severe JJ cord-320054-wqpr8v3p 111 39 acute acute JJ cord-320054-wqpr8v3p 111 40 respiratory respiratory JJ cord-320054-wqpr8v3p 111 41 syndrome syndrome NN cord-320054-wqpr8v3p 111 42 Genome genome NN cord-320054-wqpr8v3p 111 43 composition composition NN cord-320054-wqpr8v3p 111 44 and and CC cord-320054-wqpr8v3p 111 45 divergence divergence NN cord-320054-wqpr8v3p 111 46 of of IN cord-320054-wqpr8v3p 111 47 24 24 CD cord-320054-wqpr8v3p 111 48 495 495 CD cord-320054-wqpr8v3p 111 49 the the DT cord-320054-wqpr8v3p 111 50 novel novel JJ cord-320054-wqpr8v3p 111 51 coronavirus coronavirus NN cord-320054-wqpr8v3p 111 52 ( ( -LRB- cord-320054-wqpr8v3p 111 53 2019-nCoV 2019-ncov CD cord-320054-wqpr8v3p 111 54 ) ) -RRB- cord-320054-wqpr8v3p 111 55 originating originate VBG cord-320054-wqpr8v3p 111 56 in in IN cord-320054-wqpr8v3p 111 57 China China NNP cord-320054-wqpr8v3p 111 58 . . . cord-320054-wqpr8v3p 112 1 Cell cell NN cord-320054-wqpr8v3p 112 2 host host NN cord-320054-wqpr8v3p 112 3 & & CC cord-320054-wqpr8v3p 112 4 microbe microbe NN cord-320054-wqpr8v3p 112 5 A a DT cord-320054-wqpr8v3p 112 6 novel novel JJ cord-320054-wqpr8v3p 112 7 coronavirus coronavirus NN cord-320054-wqpr8v3p 112 8 499 499 CD cord-320054-wqpr8v3p 112 9 associated associate VBN cord-320054-wqpr8v3p 112 10 with with IN cord-320054-wqpr8v3p 112 11 severe severe JJ cord-320054-wqpr8v3p 112 12 acute acute JJ cord-320054-wqpr8v3p 112 13 respiratory respiratory JJ cord-320054-wqpr8v3p 112 14 syndrome syndrome NN cord-320054-wqpr8v3p 112 15 Isolation isolation NN cord-320054-wqpr8v3p 112 16 of of IN cord-320054-wqpr8v3p 112 17 a a DT cord-320054-wqpr8v3p 112 18 novel novel JJ cord-320054-wqpr8v3p 112 19 502 502 CD cord-320054-wqpr8v3p 112 20 coronavirus coronavirus NN cord-320054-wqpr8v3p 112 21 from from IN cord-320054-wqpr8v3p 112 22 a a DT cord-320054-wqpr8v3p 112 23 man man NN cord-320054-wqpr8v3p 112 24 with with IN cord-320054-wqpr8v3p 112 25 pneumonia pneumonia NN cord-320054-wqpr8v3p 112 26 in in IN cord-320054-wqpr8v3p 112 27 Saudi Saudi NNP cord-320054-wqpr8v3p 112 28 Arabia Arabia NNP cord-320054-wqpr8v3p 112 29 Properties Properties NNPS cord-320054-wqpr8v3p 112 30 of of IN cord-320054-wqpr8v3p 112 31 Coronavirus Coronavirus NNP cord-320054-wqpr8v3p 112 32 and and CC cord-320054-wqpr8v3p 112 33 SARS SARS NNP cord-320054-wqpr8v3p 112 34 - - HYPH cord-320054-wqpr8v3p 112 35 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 112 36 Structure Structure NNP cord-320054-wqpr8v3p 112 37 , , , cord-320054-wqpr8v3p 112 38 function function NN cord-320054-wqpr8v3p 112 39 , , , cord-320054-wqpr8v3p 112 40 and and CC cord-320054-wqpr8v3p 112 41 507 507 CD cord-320054-wqpr8v3p 112 42 antigenicity antigenicity NN cord-320054-wqpr8v3p 112 43 of of IN cord-320054-wqpr8v3p 112 44 the the DT cord-320054-wqpr8v3p 112 45 SARS SARS NNP cord-320054-wqpr8v3p 112 46 - - HYPH cord-320054-wqpr8v3p 112 47 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 112 48 spike spike NN cord-320054-wqpr8v3p 112 49 glycoprotein glycoprotein NN cord-320054-wqpr8v3p 112 50 Variant variant NN cord-320054-wqpr8v3p 112 51 analysis analysis NN cord-320054-wqpr8v3p 112 52 of of IN cord-320054-wqpr8v3p 112 53 SARS SARS NNP cord-320054-wqpr8v3p 112 54 - - HYPH cord-320054-wqpr8v3p 112 55 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 112 56 genomes genome NNS cord-320054-wqpr8v3p 112 57 . . . cord-320054-wqpr8v3p 113 1 Bulletin bulletin NN cord-320054-wqpr8v3p 113 2 of of IN cord-320054-wqpr8v3p 113 3 the the DT cord-320054-wqpr8v3p 113 4 World World NNP cord-320054-wqpr8v3p 113 5 509 509 CD cord-320054-wqpr8v3p 113 6 Health Health NNP cord-320054-wqpr8v3p 113 7 Organization Organization NNP cord-320054-wqpr8v3p 113 8 SARS SARS NNP cord-320054-wqpr8v3p 113 9 - - HYPH cord-320054-wqpr8v3p 113 10 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 113 11 viral viral JJ cord-320054-wqpr8v3p 113 12 spike spike NN cord-320054-wqpr8v3p 113 13 G614 g614 NN cord-320054-wqpr8v3p 113 14 mutation mutation NN cord-320054-wqpr8v3p 113 15 exhibits exhibit VBZ cord-320054-wqpr8v3p 114 1 higher high JJR cord-320054-wqpr8v3p 114 2 case case NN cord-320054-wqpr8v3p 114 3 511 511 CD cord-320054-wqpr8v3p 114 4 fatality fatality NN cord-320054-wqpr8v3p 114 5 rate rate NN cord-320054-wqpr8v3p 114 6 spike spike NN cord-320054-wqpr8v3p 114 7 ( ( -LRB- cord-320054-wqpr8v3p 114 8 S s NN cord-320054-wqpr8v3p 114 9 ) ) -RRB- cord-320054-wqpr8v3p 114 10 protein protein NN cord-320054-wqpr8v3p 114 11 be be VB cord-320054-wqpr8v3p 114 12 associated associate VBN cord-320054-wqpr8v3p 114 13 with with IN cord-320054-wqpr8v3p 114 14 higher high JJR cord-320054-wqpr8v3p 114 15 COVID-19 COVID-19 NNP cord-320054-wqpr8v3p 114 16 mortality mortality NN cord-320054-wqpr8v3p 114 17 ? ? . cord-320054-wqpr8v3p 115 1 Spike spike NN cord-320054-wqpr8v3p 115 2 mutation mutation NN cord-320054-wqpr8v3p 115 3 516 516 CD cord-320054-wqpr8v3p 115 4 pipeline pipeline NN cord-320054-wqpr8v3p 115 5 reveals reveal VBZ cord-320054-wqpr8v3p 115 6 the the DT cord-320054-wqpr8v3p 115 7 emergence emergence NN cord-320054-wqpr8v3p 115 8 of of IN cord-320054-wqpr8v3p 115 9 a a DT cord-320054-wqpr8v3p 115 10 more more RBR cord-320054-wqpr8v3p 115 11 transmissible transmissible JJ cord-320054-wqpr8v3p 115 12 form form NN cord-320054-wqpr8v3p 115 13 of of IN cord-320054-wqpr8v3p 115 14 SARS SARS NNP cord-320054-wqpr8v3p 115 15 - - HYPH cord-320054-wqpr8v3p 115 16 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 115 17 Structure Structure NNP cord-320054-wqpr8v3p 115 18 of of IN cord-320054-wqpr8v3p 115 19 the the DT cord-320054-wqpr8v3p 115 20 SARS SARS NNP cord-320054-wqpr8v3p 115 21 - - HYPH cord-320054-wqpr8v3p 115 22 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 115 23 spike spike NN cord-320054-wqpr8v3p 115 24 518 518 CD cord-320054-wqpr8v3p 115 25 receptor receptor NN cord-320054-wqpr8v3p 115 26 - - HYPH cord-320054-wqpr8v3p 115 27 binding bind VBG cord-320054-wqpr8v3p 115 28 domain domain NN cord-320054-wqpr8v3p 115 29 bound bind VBN cord-320054-wqpr8v3p 115 30 to to IN cord-320054-wqpr8v3p 115 31 the the DT cord-320054-wqpr8v3p 115 32 ACE2 ACE2 NNP cord-320054-wqpr8v3p 115 33 receptor receptor NN cord-320054-wqpr8v3p 116 1 RNA RNA NNP cord-320054-wqpr8v3p 116 2 based base VBN cord-320054-wqpr8v3p 116 3 mNGS mngs JJ cord-320054-wqpr8v3p 116 4 approach approach NN cord-320054-wqpr8v3p 116 5 identifies identify VBZ cord-320054-wqpr8v3p 116 6 a a DT cord-320054-wqpr8v3p 116 7 520 520 CD cord-320054-wqpr8v3p 116 8 novel novel JJ cord-320054-wqpr8v3p 116 9 human human JJ cord-320054-wqpr8v3p 116 10 coronavirus coronavirus NN cord-320054-wqpr8v3p 116 11 from from IN cord-320054-wqpr8v3p 116 12 two two CD cord-320054-wqpr8v3p 116 13 individual individual JJ cord-320054-wqpr8v3p 116 14 pneumonia pneumonia NN cord-320054-wqpr8v3p 116 15 cases case NNS cord-320054-wqpr8v3p 116 16 in in IN cord-320054-wqpr8v3p 116 17 2019 2019 CD cord-320054-wqpr8v3p 116 18 Wuhan Wuhan NNP cord-320054-wqpr8v3p 116 19 outbreak outbreak NN cord-320054-wqpr8v3p 116 20 . . . cord-320054-wqpr8v3p 117 1 Emerging emerge VBG cord-320054-wqpr8v3p 117 2 521 521 CD cord-320054-wqpr8v3p 117 3 microbes microbe NNS cord-320054-wqpr8v3p 117 4 & & CC cord-320054-wqpr8v3p 117 5 infections infection NNS cord-320054-wqpr8v3p 117 6 The the DT cord-320054-wqpr8v3p 117 7 early early JJ cord-320054-wqpr8v3p 117 8 523 523 CD cord-320054-wqpr8v3p 117 9 landscape landscape NN cord-320054-wqpr8v3p 117 10 of of IN cord-320054-wqpr8v3p 117 11 COVID-19 covid-19 JJ cord-320054-wqpr8v3p 117 12 vaccine vaccine NN cord-320054-wqpr8v3p 117 13 development development NN cord-320054-wqpr8v3p 117 14 in in IN cord-320054-wqpr8v3p 117 15 the the DT cord-320054-wqpr8v3p 117 16 UK UK NNP cord-320054-wqpr8v3p 117 17 and and CC cord-320054-wqpr8v3p 117 18 rest rest NN cord-320054-wqpr8v3p 117 19 of of IN cord-320054-wqpr8v3p 117 20 the the DT cord-320054-wqpr8v3p 117 21 world world NN cord-320054-wqpr8v3p 117 22 Preliminary preliminary JJ cord-320054-wqpr8v3p 117 23 identification identification NN cord-320054-wqpr8v3p 117 24 of of IN cord-320054-wqpr8v3p 117 25 potential potential JJ cord-320054-wqpr8v3p 117 26 vaccine vaccine NN cord-320054-wqpr8v3p 117 27 targets target NNS cord-320054-wqpr8v3p 117 28 for for IN cord-320054-wqpr8v3p 117 29 525 525 CD cord-320054-wqpr8v3p 117 30 the the DT cord-320054-wqpr8v3p 117 31 COVID-19 covid-19 JJ cord-320054-wqpr8v3p 117 32 coronavirus coronavirus NN cord-320054-wqpr8v3p 117 33 ( ( -LRB- cord-320054-wqpr8v3p 117 34 SARS SARS NNP cord-320054-wqpr8v3p 117 35 - - HYPH cord-320054-wqpr8v3p 117 36 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 117 37 ) ) -RRB- cord-320054-wqpr8v3p 117 38 based base VBN cord-320054-wqpr8v3p 117 39 on on IN cord-320054-wqpr8v3p 117 40 SARS SARS NNP cord-320054-wqpr8v3p 117 41 - - HYPH cord-320054-wqpr8v3p 117 42 CoV CoV NNP cord-320054-wqpr8v3p 117 43 immunological immunological JJ cord-320054-wqpr8v3p 117 44 studies studies NNPS cord-320054-wqpr8v3p 117 45 COVID-19 COVID-19 NNP cord-320054-wqpr8v3p 117 46 , , , cord-320054-wqpr8v3p 117 47 an an DT cord-320054-wqpr8v3p 117 48 emerging emerge VBG cord-320054-wqpr8v3p 117 49 528 528 CD cord-320054-wqpr8v3p 117 50 coronavirus coronavirus NN cord-320054-wqpr8v3p 117 51 infection infection NN cord-320054-wqpr8v3p 117 52 : : : cord-320054-wqpr8v3p 117 53 advances advance NNS cord-320054-wqpr8v3p 117 54 and and CC cord-320054-wqpr8v3p 117 55 prospects prospect NNS cord-320054-wqpr8v3p 117 56 in in IN cord-320054-wqpr8v3p 117 57 designing design VBG cord-320054-wqpr8v3p 117 58 and and CC cord-320054-wqpr8v3p 117 59 developing develop VBG cord-320054-wqpr8v3p 117 60 vaccines vaccine NNS cord-320054-wqpr8v3p 117 61 , , , cord-320054-wqpr8v3p 117 62 529 529 CD cord-320054-wqpr8v3p 117 63 immunotherapeutics immunotherapeutic NNS cord-320054-wqpr8v3p 117 64 , , , cord-320054-wqpr8v3p 117 65 and and CC cord-320054-wqpr8v3p 117 66 therapeutics therapeutic NNS cord-320054-wqpr8v3p 118 1 The the DT cord-320054-wqpr8v3p 118 2 SARS SARS NNP cord-320054-wqpr8v3p 118 3 - - HYPH cord-320054-wqpr8v3p 118 4 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 118 5 Vaccine Vaccine NNP cord-320054-wqpr8v3p 118 6 Pipeline Pipeline NNP cord-320054-wqpr8v3p 118 7 : : : cord-320054-wqpr8v3p 118 8 an an DT cord-320054-wqpr8v3p 118 9 Overview Overview NNP cord-320054-wqpr8v3p 118 10 . . . cord-320054-wqpr8v3p 119 1 531 531 CD cord-320054-wqpr8v3p 120 1 Current current JJ cord-320054-wqpr8v3p 120 2 tropical tropical JJ cord-320054-wqpr8v3p 120 3 medicine medicine NN cord-320054-wqpr8v3p 120 4 reports report NNS cord-320054-wqpr8v3p 121 1 The the DT cord-320054-wqpr8v3p 121 2 D614 d614 NN cord-320054-wqpr8v3p 121 3 G g NN cord-320054-wqpr8v3p 121 4 mutation mutation NN cord-320054-wqpr8v3p 121 5 in in IN cord-320054-wqpr8v3p 121 6 the the DT cord-320054-wqpr8v3p 121 7 533 533 CD cord-320054-wqpr8v3p 121 8 Epitope Epitope NNP cord-320054-wqpr8v3p 121 9 - - HYPH cord-320054-wqpr8v3p 121 10 based base VBN cord-320054-wqpr8v3p 121 11 peptide peptide NN cord-320054-wqpr8v3p 121 12 535 535 CD cord-320054-wqpr8v3p 121 13 vaccine vaccine NN cord-320054-wqpr8v3p 121 14 design design NN cord-320054-wqpr8v3p 121 15 and and CC cord-320054-wqpr8v3p 121 16 target target NN cord-320054-wqpr8v3p 121 17 site site NN cord-320054-wqpr8v3p 121 18 depiction depiction NN cord-320054-wqpr8v3p 121 19 against against IN cord-320054-wqpr8v3p 121 20 Middle Middle NNP cord-320054-wqpr8v3p 121 21 East East NNP cord-320054-wqpr8v3p 121 22 Respiratory Respiratory NNP cord-320054-wqpr8v3p 121 23 Syndrome Syndrome NNP cord-320054-wqpr8v3p 121 24 Coronavirus Coronavirus NNP cord-320054-wqpr8v3p 121 25 : : : cord-320054-wqpr8v3p 121 26 An an DT cord-320054-wqpr8v3p 121 27 536 536 CD cord-320054-wqpr8v3p 121 28 immune immune JJ cord-320054-wqpr8v3p 121 29 - - HYPH cord-320054-wqpr8v3p 121 30 informatics informatics NN cord-320054-wqpr8v3p 121 31 study study NN cord-320054-wqpr8v3p 121 32 CoV CoV NNP cord-320054-wqpr8v3p 121 33 spike spike NN cord-320054-wqpr8v3p 121 34 protein protein NNP cord-320054-wqpr8v3p 121 35 : : : cord-320054-wqpr8v3p 121 36 a a DT cord-320054-wqpr8v3p 121 37 key key JJ cord-320054-wqpr8v3p 121 38 target target NN cord-320054-wqpr8v3p 121 39 for for IN cord-320054-wqpr8v3p 121 40 antivirals antiviral NNS cord-320054-wqpr8v3p 121 41 . . . cord-320054-wqpr8v3p 122 1 538 538 CD cord-320054-wqpr8v3p 123 1 Expert expert JJ cord-320054-wqpr8v3p 123 2 opinion opinion NN cord-320054-wqpr8v3p 123 3 on on IN cord-320054-wqpr8v3p 123 4 therapeutic therapeutic JJ cord-320054-wqpr8v3p 123 5 targets target NNS cord-320054-wqpr8v3p 123 6 SARS SARS NNP cord-320054-wqpr8v3p 123 7 - - HYPH cord-320054-wqpr8v3p 123 8 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 123 9 identified identify VBN cord-320054-wqpr8v3p 123 10 by by IN cord-320054-wqpr8v3p 123 11 high high JJ cord-320054-wqpr8v3p 123 12 - - HYPH cord-320054-wqpr8v3p 123 13 throughput throughput NN cord-320054-wqpr8v3p 123 14 single single JJ cord-320054-wqpr8v3p 123 15 - - HYPH cord-320054-wqpr8v3p 123 16 cell cell NN cord-320054-wqpr8v3p 123 17 sequencing sequencing NN cord-320054-wqpr8v3p 123 18 of of IN cord-320054-wqpr8v3p 123 19 convalescent convalescent JJ cord-320054-wqpr8v3p 123 20 patients patient NNS cord-320054-wqpr8v3p 123 21 ' ' POS cord-320054-wqpr8v3p 123 22 B b NN cord-320054-wqpr8v3p 123 23 cells cell NNS cord-320054-wqpr8v3p 124 1 Potent potent JJ cord-320054-wqpr8v3p 124 2 cross cross JJ cord-320054-wqpr8v3p 124 3 - - JJ cord-320054-wqpr8v3p 124 4 reactive reactive JJ cord-320054-wqpr8v3p 124 5 543 543 CD cord-320054-wqpr8v3p 124 6 neutralization neutralization NN cord-320054-wqpr8v3p 124 7 of of IN cord-320054-wqpr8v3p 124 8 SARS SARS NNP cord-320054-wqpr8v3p 124 9 coronavirus coronavirus NN cord-320054-wqpr8v3p 124 10 isolates isolate NNS cord-320054-wqpr8v3p 124 11 by by IN cord-320054-wqpr8v3p 124 12 human human JJ cord-320054-wqpr8v3p 124 13 monoclonal monoclonal JJ cord-320054-wqpr8v3p 124 14 antibodies antibody NNS cord-320054-wqpr8v3p 124 15 . . . cord-320054-wqpr8v3p 125 1 Proceedings proceeding NNS cord-320054-wqpr8v3p 125 2 of of IN cord-320054-wqpr8v3p 125 3 the the DT cord-320054-wqpr8v3p 125 4 544 544 CD cord-320054-wqpr8v3p 125 5 National National NNP cord-320054-wqpr8v3p 125 6 Academy Academy NNP cord-320054-wqpr8v3p 125 7 of of IN cord-320054-wqpr8v3p 125 8 Sciences Sciences NNPS cord-320054-wqpr8v3p 125 9 A a DT cord-320054-wqpr8v3p 125 10 193-amino 193-amino CD cord-320054-wqpr8v3p 125 11 acid acid NN cord-320054-wqpr8v3p 125 12 fragment fragment NN cord-320054-wqpr8v3p 125 13 of of IN cord-320054-wqpr8v3p 125 14 the the DT cord-320054-wqpr8v3p 125 15 SARS SARS NNP cord-320054-wqpr8v3p 125 16 546 546 CD cord-320054-wqpr8v3p 125 17 coronavirus coronavirus NN cord-320054-wqpr8v3p 125 18 S s NN cord-320054-wqpr8v3p 125 19 protein protein NN cord-320054-wqpr8v3p 125 20 efficiently efficiently RB cord-320054-wqpr8v3p 125 21 binds bind VBZ cord-320054-wqpr8v3p 125 22 angiotensin angiotensin NN cord-320054-wqpr8v3p 125 23 - - HYPH cord-320054-wqpr8v3p 125 24 converting convert VBG cord-320054-wqpr8v3p 125 25 enzyme enzyme NN cord-320054-wqpr8v3p 125 26 2 2 CD cord-320054-wqpr8v3p 125 27 Spike Spike NNP cord-320054-wqpr8v3p 125 28 Mutation mutation NN cord-320054-wqpr8v3p 125 29 Increases increase VBZ cord-320054-wqpr8v3p 126 1 SARS SARS NNP cord-320054-wqpr8v3p 126 2 CoV-2 CoV-2 NNP cord-320054-wqpr8v3p 127 1 Susceptibility susceptibility NN cord-320054-wqpr8v3p 127 2 to to IN cord-320054-wqpr8v3p 127 3 Neutralization Neutralization NNP cord-320054-wqpr8v3p 127 4 Global Global NNP cord-320054-wqpr8v3p 127 5 initiative initiative NN cord-320054-wqpr8v3p 127 6 on on IN cord-320054-wqpr8v3p 127 7 sharing share VBG cord-320054-wqpr8v3p 127 8 all all DT cord-320054-wqpr8v3p 127 9 influenza influenza NN cord-320054-wqpr8v3p 127 10 data data NN cord-320054-wqpr8v3p 127 11 - - : cord-320054-wqpr8v3p 127 12 from from IN cord-320054-wqpr8v3p 127 13 vision vision NN cord-320054-wqpr8v3p 127 14 to to IN cord-320054-wqpr8v3p 127 15 reality reality NN cord-320054-wqpr8v3p 127 16 Clustal Clustal NNP cord-320054-wqpr8v3p 127 17 Omega Omega NNP cord-320054-wqpr8v3p 127 18 for for IN cord-320054-wqpr8v3p 127 19 making make VBG cord-320054-wqpr8v3p 127 20 accurate accurate JJ cord-320054-wqpr8v3p 127 21 alignments alignment NNS cord-320054-wqpr8v3p 127 22 of of IN cord-320054-wqpr8v3p 127 23 many many JJ cord-320054-wqpr8v3p 127 24 protein protein NN cord-320054-wqpr8v3p 127 25 sequences sequence NNS cord-320054-wqpr8v3p 127 26 MSAViewer MSAViewer NNP cord-320054-wqpr8v3p 127 27 : : : cord-320054-wqpr8v3p 128 1 555 555 CD cord-320054-wqpr8v3p 128 2 interactive interactive JJ cord-320054-wqpr8v3p 128 3 JavaScript JavaScript NNP cord-320054-wqpr8v3p 128 4 visualization visualization NN cord-320054-wqpr8v3p 128 5 of of IN cord-320054-wqpr8v3p 128 6 multiple multiple JJ cord-320054-wqpr8v3p 128 7 sequence sequence NN cord-320054-wqpr8v3p 128 8 alignments alignment NNS cord-320054-wqpr8v3p 129 1 CDD CDD NNP cord-320054-wqpr8v3p 129 2 / / SYM cord-320054-wqpr8v3p 129 3 SPARCLE SPARCLE NNP cord-320054-wqpr8v3p 129 4 : : : cord-320054-wqpr8v3p 130 1 the the DT cord-320054-wqpr8v3p 130 2 558 558 CD cord-320054-wqpr8v3p 130 3 conserved conserved JJ cord-320054-wqpr8v3p 130 4 domain domain NN cord-320054-wqpr8v3p 130 5 database database NN cord-320054-wqpr8v3p 130 6 in in IN cord-320054-wqpr8v3p 130 7 2020 2020 CD cord-320054-wqpr8v3p 131 1 Identifying identify VBG cord-320054-wqpr8v3p 131 2 candidate candidate NN cord-320054-wqpr8v3p 131 3 subunit subunit NN cord-320054-wqpr8v3p 131 4 vaccines vaccine NNS cord-320054-wqpr8v3p 131 5 using use VBG cord-320054-wqpr8v3p 131 6 an an DT cord-320054-wqpr8v3p 131 7 562 562 CD cord-320054-wqpr8v3p 131 8 alignment alignment NN cord-320054-wqpr8v3p 131 9 - - HYPH cord-320054-wqpr8v3p 131 10 independent independent JJ cord-320054-wqpr8v3p 131 11 method method NN cord-320054-wqpr8v3p 131 12 based base VBN cord-320054-wqpr8v3p 131 13 on on IN cord-320054-wqpr8v3p 131 14 principal principal JJ cord-320054-wqpr8v3p 131 15 amino amino NN cord-320054-wqpr8v3p 131 16 acid acid NN cord-320054-wqpr8v3p 131 17 properties property NNS cord-320054-wqpr8v3p 131 18 Identification identification NN cord-320054-wqpr8v3p 131 19 and and CC cord-320054-wqpr8v3p 131 20 validation validation NN cord-320054-wqpr8v3p 131 21 of of IN cord-320054-wqpr8v3p 131 22 specific specific JJ cord-320054-wqpr8v3p 131 23 B b NN cord-320054-wqpr8v3p 131 24 - - HYPH cord-320054-wqpr8v3p 131 25 cell cell NN cord-320054-wqpr8v3p 131 26 epitopes epitope NNS cord-320054-wqpr8v3p 131 27 of of IN cord-320054-wqpr8v3p 131 28 hantaviruses hantaviruse NNS cord-320054-wqpr8v3p 131 29 associated associate VBN cord-320054-wqpr8v3p 131 30 to to IN cord-320054-wqpr8v3p 131 31 hemorrhagic hemorrhagic JJ cord-320054-wqpr8v3p 131 32 565 565 CD cord-320054-wqpr8v3p 131 33 fever fever NN cord-320054-wqpr8v3p 131 34 and and CC cord-320054-wqpr8v3p 131 35 renal renal JJ cord-320054-wqpr8v3p 131 36 syndrome syndrome NN cord-320054-wqpr8v3p 132 1 The the DT cord-320054-wqpr8v3p 132 2 immune immune JJ cord-320054-wqpr8v3p 132 3 epitope epitope NN cord-320054-wqpr8v3p 132 4 database database NN cord-320054-wqpr8v3p 132 5 and and CC cord-320054-wqpr8v3p 132 6 567 567 CD cord-320054-wqpr8v3p 132 7 analysis analysis NN cord-320054-wqpr8v3p 132 8 resource resource NN cord-320054-wqpr8v3p 132 9 : : : cord-320054-wqpr8v3p 132 10 from from IN cord-320054-wqpr8v3p 132 11 vision vision NN cord-320054-wqpr8v3p 132 12 to to IN cord-320054-wqpr8v3p 132 13 blueprint blueprint NN cord-320054-wqpr8v3p 132 14 BepiPred-2.0 BepiPred-2.0 NNP cord-320054-wqpr8v3p 132 15 : : : cord-320054-wqpr8v3p 133 1 improving improve VBG cord-320054-wqpr8v3p 133 2 sequence sequence NN cord-320054-wqpr8v3p 133 3 - - HYPH cord-320054-wqpr8v3p 133 4 based base VBN cord-320054-wqpr8v3p 133 5 B b NN cord-320054-wqpr8v3p 133 6 - - HYPH cord-320054-wqpr8v3p 133 7 cell cell NN cord-320054-wqpr8v3p 133 8 569 569 CD cord-320054-wqpr8v3p 133 9 epitope epitope NN cord-320054-wqpr8v3p 133 10 prediction prediction NN cord-320054-wqpr8v3p 133 11 using use VBG cord-320054-wqpr8v3p 133 12 conformational conformational JJ cord-320054-wqpr8v3p 133 13 epitopes epitope NNS cord-320054-wqpr8v3p 133 14 Influence influence NN cord-320054-wqpr8v3p 133 15 of of IN cord-320054-wqpr8v3p 133 16 protein protein NN cord-320054-wqpr8v3p 133 17 flexibility flexibility NN cord-320054-wqpr8v3p 133 18 and and CC cord-320054-wqpr8v3p 133 19 571 571 CD cord-320054-wqpr8v3p 133 20 peptide peptide NN cord-320054-wqpr8v3p 133 21 conformation conformation NN cord-320054-wqpr8v3p 133 22 on on IN cord-320054-wqpr8v3p 133 23 reactivity reactivity NN cord-320054-wqpr8v3p 133 24 of of IN cord-320054-wqpr8v3p 133 25 monoclonal monoclonal JJ cord-320054-wqpr8v3p 133 26 anti anti JJ cord-320054-wqpr8v3p 133 27 - - JJ cord-320054-wqpr8v3p 133 28 peptide peptide JJ cord-320054-wqpr8v3p 133 29 antibodies antibody NNS cord-320054-wqpr8v3p 133 30 with with IN cord-320054-wqpr8v3p 133 31 a a DT cord-320054-wqpr8v3p 133 32 protein protein NN cord-320054-wqpr8v3p 133 33 alpha alpha NN cord-320054-wqpr8v3p 133 34 - - HYPH cord-320054-wqpr8v3p 133 35 helix helix NN cord-320054-wqpr8v3p 133 36 Conformational Conformational NNP cord-320054-wqpr8v3p 133 37 B B NNP cord-320054-wqpr8v3p 133 38 - - HYPH cord-320054-wqpr8v3p 133 39 cell cell NN cord-320054-wqpr8v3p 133 40 epitope epitope NN cord-320054-wqpr8v3p 133 41 prediction prediction NN cord-320054-wqpr8v3p 133 42 on on IN cord-320054-wqpr8v3p 133 43 antigen antigen NN cord-320054-wqpr8v3p 133 44 protein protein NN cord-320054-wqpr8v3p 133 45 574 574 CD cord-320054-wqpr8v3p 133 46 structures structure NNS cord-320054-wqpr8v3p 133 47 : : : cord-320054-wqpr8v3p 133 48 a a DT cord-320054-wqpr8v3p 133 49 review review NN cord-320054-wqpr8v3p 133 50 of of IN cord-320054-wqpr8v3p 133 51 current current JJ cord-320054-wqpr8v3p 133 52 algorithms algorithm NNS cord-320054-wqpr8v3p 133 53 and and CC cord-320054-wqpr8v3p 133 54 comparison comparison NN cord-320054-wqpr8v3p 133 55 with with IN cord-320054-wqpr8v3p 133 56 common common JJ cord-320054-wqpr8v3p 133 57 binding binding NN cord-320054-wqpr8v3p 133 58 site site NN cord-320054-wqpr8v3p 133 59 prediction prediction NN cord-320054-wqpr8v3p 133 60 575 575 CD cord-320054-wqpr8v3p 133 61 methods method NNS cord-320054-wqpr8v3p 134 1 Bioinformatics Bioinformatics NNP cord-320054-wqpr8v3p 134 2 resources resource NNS cord-320054-wqpr8v3p 134 3 and and CC cord-320054-wqpr8v3p 134 4 tools tool NNS cord-320054-wqpr8v3p 134 5 for for IN cord-320054-wqpr8v3p 134 6 577 577 CD cord-320054-wqpr8v3p 134 7 conformational conformational JJ cord-320054-wqpr8v3p 134 8 B b NN cord-320054-wqpr8v3p 134 9 - - HYPH cord-320054-wqpr8v3p 134 10 cell cell NN cord-320054-wqpr8v3p 134 11 epitope epitope NN cord-320054-wqpr8v3p 134 12 prediction prediction NN cord-320054-wqpr8v3p 134 13 . . . cord-320054-wqpr8v3p 135 1 Computational computational JJ cord-320054-wqpr8v3p 135 2 and and CC cord-320054-wqpr8v3p 135 3 mathematical mathematical JJ cord-320054-wqpr8v3p 135 4 methods method NNS cord-320054-wqpr8v3p 135 5 in in IN cord-320054-wqpr8v3p 135 6 medicine medicine NN cord-320054-wqpr8v3p 135 7 Reliable Reliable NNP cord-320054-wqpr8v3p 135 8 B B NNP cord-320054-wqpr8v3p 135 9 cell cell NN cord-320054-wqpr8v3p 135 10 epitope epitope NN cord-320054-wqpr8v3p 135 11 predictions prediction NNS cord-320054-wqpr8v3p 135 12 : : : cord-320054-wqpr8v3p 135 13 impacts impact NNS cord-320054-wqpr8v3p 135 14 of of IN cord-320054-wqpr8v3p 135 15 580 580 CD cord-320054-wqpr8v3p 135 16 method method NN cord-320054-wqpr8v3p 135 17 development development NN cord-320054-wqpr8v3p 135 18 and and CC cord-320054-wqpr8v3p 135 19 improved improve VBN cord-320054-wqpr8v3p 135 20 benchmarking benchmarking NN cord-320054-wqpr8v3p 136 1 It -PRON- PRP cord-320054-wqpr8v3p 136 2 is be VBZ cord-320054-wqpr8v3p 136 3 grateful grateful JJ cord-320054-wqpr8v3p 136 4 to to IN cord-320054-wqpr8v3p 136 5 Zijun Zijun NNP cord-320054-wqpr8v3p 136 6 Shu Shu NNP cord-320054-wqpr8v3p 136 7 for for IN cord-320054-wqpr8v3p 136 8 his -PRON- PRP$ cord-320054-wqpr8v3p 136 9 management management NN cord-320054-wqpr8v3p 136 10 of of IN cord-320054-wqpr8v3p 136 11 manuscript manuscript NN cord-320054-wqpr8v3p 136 12 reference reference NN cord-320054-wqpr8v3p 136 13 . . . cord-320054-wqpr8v3p 136 14 _SP