id	sid	tid	token	lemma	pos
cord-300194-nsp53lv6	1	1	key	key	JJ
cord-300194-nsp53lv6	1	2	:	:	:
cord-300194-nsp53lv6	1	3	cord-300194-nsp53lv6	cord-300194-nsp53lv6	JJ
cord-300194-nsp53lv6	1	4	authors	author	NNS
cord-300194-nsp53lv6	1	5	:	:	:
cord-300194-nsp53lv6	1	6	Rath	Rath	NNP
cord-300194-nsp53lv6	1	7	,	,	,
cord-300194-nsp53lv6	1	8	Soumya	Soumya	NNP
cord-300194-nsp53lv6	1	9	Lipsa	Lipsa	NNP
cord-300194-nsp53lv6	1	10	;	;	:
cord-300194-nsp53lv6	1	11	Kumar	Kumar	NNP
cord-300194-nsp53lv6	1	12	,	,	,
cord-300194-nsp53lv6	1	13	Kishant	Kishant	NNP
cord-300194-nsp53lv6	1	14	title	title	NN
cord-300194-nsp53lv6	1	15	:	:	:
cord-300194-nsp53lv6	1	16	Investigation	investigation	NN
cord-300194-nsp53lv6	1	17	of	of	IN
cord-300194-nsp53lv6	1	18	the	the	DT
cord-300194-nsp53lv6	1	19	effect	effect	NN
cord-300194-nsp53lv6	1	20	of	of	IN
cord-300194-nsp53lv6	1	21	temperature	temperature	NN
cord-300194-nsp53lv6	1	22	on	on	IN
cord-300194-nsp53lv6	1	23	the	the	DT
cord-300194-nsp53lv6	1	24	structure	structure	NN
cord-300194-nsp53lv6	1	25	of	of	IN
cord-300194-nsp53lv6	1	26	SARS	SARS	NNP
cord-300194-nsp53lv6	1	27	-	-	HYPH
cord-300194-nsp53lv6	1	28	Cov-2	Cov-2	NNP
cord-300194-nsp53lv6	1	29	Spike	Spike	NNP
cord-300194-nsp53lv6	1	30	Protein	Protein	NNP
cord-300194-nsp53lv6	1	31	by	by	IN
cord-300194-nsp53lv6	1	32	Molecular	Molecular	NNP
cord-300194-nsp53lv6	1	33	Dynamics	Dynamics	NNPS
cord-300194-nsp53lv6	1	34	Simulations	Simulations	NNPS
cord-300194-nsp53lv6	1	35	date	date	NN
cord-300194-nsp53lv6	1	36	:	:	:
cord-300194-nsp53lv6	1	37	2020	2020	CD
cord-300194-nsp53lv6	1	38	-	-	HYPH
cord-300194-nsp53lv6	1	39	06	06	CD
cord-300194-nsp53lv6	1	40	-	-	SYM
cord-300194-nsp53lv6	1	41	19	19	CD
cord-300194-nsp53lv6	1	42	journal	journal	NN
cord-300194-nsp53lv6	1	43	:	:	:
cord-300194-nsp53lv6	2	1	bioRxiv	biorxiv	IN
cord-300194-nsp53lv6	2	2	DOI	DOI	NNP
cord-300194-nsp53lv6	2	3	:	:	:
cord-300194-nsp53lv6	3	1	10.1101/2020.06.10.145086	10.1101/2020.06.10.145086	CD
cord-300194-nsp53lv6	3	2	sha	sha	NN
cord-300194-nsp53lv6	3	3	:	:	:
cord-300194-nsp53lv6	3	4	2fcdeae9e345742f6b84f4b2d0cfb4e8a5087438	2fcdeae9e345742f6b84f4b2d0cfb4e8a5087438	ADD
cord-300194-nsp53lv6	3	5	doc_id	doc_id	CD
cord-300194-nsp53lv6	3	6	:	:	:
cord-300194-nsp53lv6	3	7	300194	300194	CD
cord-300194-nsp53lv6	3	8	cord_uid	cord_uid	FW
cord-300194-nsp53lv6	3	9	:	:	:
cord-300194-nsp53lv6	4	1	nsp53lv6	nsp53lv6	:
cord-300194-nsp53lv6	4	2	Statistical	statistical	JJ
cord-300194-nsp53lv6	4	3	and	and	CC
cord-300194-nsp53lv6	4	4	epidemiological	epidemiological	JJ
cord-300194-nsp53lv6	4	5	data	datum	NNS
cord-300194-nsp53lv6	4	6	imply	imply	VBP
cord-300194-nsp53lv6	4	7	temperature	temperature	NN
cord-300194-nsp53lv6	4	8	sensitivity	sensitivity	NN
cord-300194-nsp53lv6	4	9	of	of	IN
cord-300194-nsp53lv6	4	10	the	the	DT
cord-300194-nsp53lv6	4	11	SARS	SARS	NNP
cord-300194-nsp53lv6	4	12	-	-	HYPH
cord-300194-nsp53lv6	4	13	CoV-2	CoV-2	NNP
cord-300194-nsp53lv6	4	14	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	4	15	.	.	.
cord-300194-nsp53lv6	5	1	However	however	RB
cord-300194-nsp53lv6	5	2	,	,	,
cord-300194-nsp53lv6	5	3	the	the	DT
cord-300194-nsp53lv6	5	4	molecular	molecular	JJ
cord-300194-nsp53lv6	5	5	level	level	NN
cord-300194-nsp53lv6	5	6	understanding	understanding	NN
cord-300194-nsp53lv6	5	7	of	of	IN
cord-300194-nsp53lv6	5	8	the	the	DT
cord-300194-nsp53lv6	5	9	virus	virus	NN
cord-300194-nsp53lv6	5	10	structure	structure	NN
cord-300194-nsp53lv6	5	11	at	at	IN
cord-300194-nsp53lv6	5	12	different	different	JJ
cord-300194-nsp53lv6	5	13	temperature	temperature	NN
cord-300194-nsp53lv6	5	14	is	be	VBZ
cord-300194-nsp53lv6	5	15	still	still	RB
cord-300194-nsp53lv6	5	16	not	not	RB
cord-300194-nsp53lv6	5	17	clear	clear	JJ
cord-300194-nsp53lv6	5	18	.	.	.
cord-300194-nsp53lv6	6	1	Spike	spike	NN
cord-300194-nsp53lv6	6	2	protein	protein	NN
cord-300194-nsp53lv6	6	3	is	be	VBZ
cord-300194-nsp53lv6	6	4	the	the	DT
cord-300194-nsp53lv6	6	5	outermost	outermost	JJS
cord-300194-nsp53lv6	6	6	structural	structural	JJ
cord-300194-nsp53lv6	6	7	protein	protein	NN
cord-300194-nsp53lv6	6	8	of	of	IN
cord-300194-nsp53lv6	6	9	the	the	DT
cord-300194-nsp53lv6	6	10	SARS	SARS	NNP
cord-300194-nsp53lv6	6	11	-	-	HYPH
cord-300194-nsp53lv6	6	12	CoV-2	CoV-2	NNP
cord-300194-nsp53lv6	6	13	virus	virus	NN
cord-300194-nsp53lv6	6	14	which	which	WDT
cord-300194-nsp53lv6	6	15	interacts	interact	VBZ
cord-300194-nsp53lv6	6	16	with	with	IN
cord-300194-nsp53lv6	6	17	the	the	DT
cord-300194-nsp53lv6	6	18	Angiotensin	Angiotensin	NNP
cord-300194-nsp53lv6	6	19	Converting	Converting	NNP
cord-300194-nsp53lv6	6	20	Enzyme	Enzyme	NNP
cord-300194-nsp53lv6	6	21	2	2	CD
cord-300194-nsp53lv6	6	22	(	(	-LRB-
cord-300194-nsp53lv6	6	23	ACE2	ACE2	NNP
cord-300194-nsp53lv6	6	24	)	)	-RRB-
cord-300194-nsp53lv6	6	25	,	,	,
cord-300194-nsp53lv6	6	26	a	a	DT
cord-300194-nsp53lv6	6	27	human	human	JJ
cord-300194-nsp53lv6	6	28	receptor	receptor	NN
cord-300194-nsp53lv6	6	29	,	,	,
cord-300194-nsp53lv6	6	30	and	and	CC
cord-300194-nsp53lv6	6	31	enters	enter	VBZ
cord-300194-nsp53lv6	6	32	the	the	DT
cord-300194-nsp53lv6	6	33	respiratory	respiratory	JJ
cord-300194-nsp53lv6	6	34	system	system	NN
cord-300194-nsp53lv6	6	35	.	.	.
cord-300194-nsp53lv6	7	1	In	in	IN
cord-300194-nsp53lv6	7	2	this	this	DT
cord-300194-nsp53lv6	7	3	study	study	NN
cord-300194-nsp53lv6	7	4	,	,	,
cord-300194-nsp53lv6	7	5	we	-PRON-	PRP
cord-300194-nsp53lv6	7	6	performed	perform	VBD
cord-300194-nsp53lv6	7	7	an	an	DT
cord-300194-nsp53lv6	7	8	all	all	DT
cord-300194-nsp53lv6	7	9	atom	atom	NN
cord-300194-nsp53lv6	7	10	molecular	molecular	JJ
cord-300194-nsp53lv6	7	11	dynamics	dynamic	NNS
cord-300194-nsp53lv6	7	12	simulation	simulation	NN
cord-300194-nsp53lv6	7	13	to	to	TO
cord-300194-nsp53lv6	7	14	study	study	VB
cord-300194-nsp53lv6	7	15	the	the	DT
cord-300194-nsp53lv6	7	16	effect	effect	NN
cord-300194-nsp53lv6	7	17	of	of	IN
cord-300194-nsp53lv6	7	18	temperature	temperature	NN
cord-300194-nsp53lv6	7	19	on	on	IN
cord-300194-nsp53lv6	7	20	the	the	DT
cord-300194-nsp53lv6	7	21	structure	structure	NN
cord-300194-nsp53lv6	7	22	of	of	IN
cord-300194-nsp53lv6	7	23	the	the	DT
cord-300194-nsp53lv6	7	24	Spike	Spike	NNP
cord-300194-nsp53lv6	7	25	protein	protein	NN
cord-300194-nsp53lv6	7	26	.	.	.
cord-300194-nsp53lv6	8	1	After	after	IN
cord-300194-nsp53lv6	8	2	200ns	200ns	NNP
cord-300194-nsp53lv6	8	3	of	of	IN
cord-300194-nsp53lv6	8	4	simulation	simulation	NN
cord-300194-nsp53lv6	8	5	at	at	IN
cord-300194-nsp53lv6	8	6	different	different	JJ
cord-300194-nsp53lv6	8	7	temperatures	temperature	NNS
cord-300194-nsp53lv6	8	8	,	,	,
cord-300194-nsp53lv6	8	9	we	-PRON-	PRP
cord-300194-nsp53lv6	8	10	came	come	VBD
cord-300194-nsp53lv6	8	11	across	across	IN
cord-300194-nsp53lv6	8	12	some	some	DT
cord-300194-nsp53lv6	8	13	interesting	interesting	JJ
cord-300194-nsp53lv6	8	14	phenomena	phenomenon	NNS
cord-300194-nsp53lv6	8	15	exhibited	exhibit	VBN
cord-300194-nsp53lv6	8	16	by	by	IN
cord-300194-nsp53lv6	8	17	the	the	DT
cord-300194-nsp53lv6	8	18	protein	protein	NN
cord-300194-nsp53lv6	8	19	.	.	.
cord-300194-nsp53lv6	9	1	We	-PRON-	PRP
cord-300194-nsp53lv6	9	2	found	find	VBD
cord-300194-nsp53lv6	9	3	that	that	IN
cord-300194-nsp53lv6	9	4	the	the	DT
cord-300194-nsp53lv6	9	5	solvent	solvent	NN
cord-300194-nsp53lv6	9	6	exposed	expose	VBD
cord-300194-nsp53lv6	9	7	domain	domain	NN
cord-300194-nsp53lv6	9	8	of	of	IN
cord-300194-nsp53lv6	9	9	Spike	Spike	NNP
cord-300194-nsp53lv6	9	10	protein	protein	NN
cord-300194-nsp53lv6	9	11	,	,	,
cord-300194-nsp53lv6	9	12	namely	namely	RB
cord-300194-nsp53lv6	9	13	S1	s1	NN
cord-300194-nsp53lv6	9	14	,	,	,
cord-300194-nsp53lv6	9	15	is	be	VBZ
cord-300194-nsp53lv6	9	16	more	more	RBR
cord-300194-nsp53lv6	9	17	mobile	mobile	JJ
cord-300194-nsp53lv6	9	18	than	than	IN
cord-300194-nsp53lv6	9	19	the	the	DT
cord-300194-nsp53lv6	9	20	transmembrane	transmembrane	NN
cord-300194-nsp53lv6	9	21	domain	domain	NN
cord-300194-nsp53lv6	9	22	,	,	,
cord-300194-nsp53lv6	9	23	S2	S2	NNP
cord-300194-nsp53lv6	9	24	.	.	.
cord-300194-nsp53lv6	10	1	Structural	structural	JJ
cord-300194-nsp53lv6	10	2	studies	study	NNS
cord-300194-nsp53lv6	10	3	implied	imply	VBD
cord-300194-nsp53lv6	10	4	the	the	DT
cord-300194-nsp53lv6	10	5	presence	presence	NN
cord-300194-nsp53lv6	10	6	of	of	IN
cord-300194-nsp53lv6	10	7	several	several	JJ
cord-300194-nsp53lv6	10	8	charged	charge	VBN
cord-300194-nsp53lv6	10	9	residues	residue	NNS
cord-300194-nsp53lv6	10	10	on	on	IN
cord-300194-nsp53lv6	10	11	the	the	DT
cord-300194-nsp53lv6	10	12	surface	surface	NN
cord-300194-nsp53lv6	10	13	of	of	IN
cord-300194-nsp53lv6	10	14	N	n	CD
cord-300194-nsp53lv6	10	15	-	-	HYPH
cord-300194-nsp53lv6	10	16	terminal	terminal	NN
cord-300194-nsp53lv6	10	17	Domain	domain	NN
cord-300194-nsp53lv6	10	18	of	of	IN
cord-300194-nsp53lv6	10	19	S1	s1	NN
cord-300194-nsp53lv6	10	20	which	which	WDT
cord-300194-nsp53lv6	10	21	are	be	VBP
cord-300194-nsp53lv6	10	22	optimally	optimally	RB
cord-300194-nsp53lv6	10	23	oriented	orient	VBN
cord-300194-nsp53lv6	10	24	at	at	IN
cord-300194-nsp53lv6	10	25	10	10	CD
cord-300194-nsp53lv6	10	26	-	-	SYM
cord-300194-nsp53lv6	10	27	30	30	CD
cord-300194-nsp53lv6	10	28	°	°	NN
cord-300194-nsp53lv6	10	29	C	c	NN
cord-300194-nsp53lv6	10	30	.	.	.
cord-300194-nsp53lv6	11	1	Bioinformatics	bioinformatics	NN
cord-300194-nsp53lv6	11	2	analyses	analysis	NNS
cord-300194-nsp53lv6	11	3	indicated	indicate	VBD
cord-300194-nsp53lv6	11	4	that	that	IN
cord-300194-nsp53lv6	11	5	it	-PRON-	PRP
cord-300194-nsp53lv6	11	6	is	be	VBZ
cord-300194-nsp53lv6	11	7	capable	capable	JJ
cord-300194-nsp53lv6	11	8	of	of	IN
cord-300194-nsp53lv6	11	9	binding	bind	VBG
cord-300194-nsp53lv6	11	10	to	to	IN
cord-300194-nsp53lv6	11	11	other	other	JJ
cord-300194-nsp53lv6	11	12	human	human	JJ
cord-300194-nsp53lv6	11	13	receptors	receptor	NNS
cord-300194-nsp53lv6	11	14	and	and	CC
cord-300194-nsp53lv6	11	15	should	should	MD
cord-300194-nsp53lv6	11	16	not	not	RB
cord-300194-nsp53lv6	11	17	be	be	VB
cord-300194-nsp53lv6	11	18	disregarded	disregard	VBN
cord-300194-nsp53lv6	11	19	.	.	.
cord-300194-nsp53lv6	12	1	Additionally	additionally	RB
cord-300194-nsp53lv6	12	2	,	,	,
cord-300194-nsp53lv6	12	3	we	-PRON-	PRP
cord-300194-nsp53lv6	12	4	found	find	VBD
cord-300194-nsp53lv6	12	5	that	that	IN
cord-300194-nsp53lv6	12	6	receptor	receptor	NN
cord-300194-nsp53lv6	12	7	binding	bind	VBG
cord-300194-nsp53lv6	12	8	motif	motif	NN
cord-300194-nsp53lv6	12	9	(	(	-LRB-
cord-300194-nsp53lv6	12	10	RBM	RBM	NNP
cord-300194-nsp53lv6	12	11	)	)	-RRB-
cord-300194-nsp53lv6	12	12	,	,	,
cord-300194-nsp53lv6	12	13	present	present	JJ
cord-300194-nsp53lv6	12	14	on	on	IN
cord-300194-nsp53lv6	12	15	the	the	DT
cord-300194-nsp53lv6	12	16	receptor	receptor	NN
cord-300194-nsp53lv6	12	17	binding	bind	VBG
cord-300194-nsp53lv6	12	18	domain	domain	NN
cord-300194-nsp53lv6	12	19	(	(	-LRB-
cord-300194-nsp53lv6	12	20	RBD	RBD	NNP
cord-300194-nsp53lv6	12	21	)	)	-RRB-
cord-300194-nsp53lv6	12	22	of	of	IN
cord-300194-nsp53lv6	12	23	S1	s1	NN
cord-300194-nsp53lv6	12	24	,	,	,
cord-300194-nsp53lv6	12	25	begins	begin	VBZ
cord-300194-nsp53lv6	12	26	to	to	TO
cord-300194-nsp53lv6	12	27	close	close	VB
cord-300194-nsp53lv6	12	28	around	around	RB
cord-300194-nsp53lv6	12	29	temperature	temperature	NN
cord-300194-nsp53lv6	12	30	of	of	IN
cord-300194-nsp53lv6	12	31	40	40	CD
cord-300194-nsp53lv6	12	32	°	°	NN
cord-300194-nsp53lv6	12	33	C	c	NN
cord-300194-nsp53lv6	12	34	and	and	CC
cord-300194-nsp53lv6	12	35	attains	attain	VBZ
cord-300194-nsp53lv6	12	36	a	a	DT
cord-300194-nsp53lv6	12	37	completely	completely	RB
cord-300194-nsp53lv6	12	38	closed	closed	JJ
cord-300194-nsp53lv6	12	39	conformation	conformation	NN
cord-300194-nsp53lv6	12	40	at	at	IN
cord-300194-nsp53lv6	12	41	50	50	CD
cord-300194-nsp53lv6	12	42	°	°	NN
cord-300194-nsp53lv6	12	43	C	c	NN
cord-300194-nsp53lv6	12	44	.	.	.
cord-300194-nsp53lv6	13	1	The	the	DT
cord-300194-nsp53lv6	13	2	closed	closed	JJ
cord-300194-nsp53lv6	13	3	conformation	conformation	NN
cord-300194-nsp53lv6	13	4	disables	disable	VBZ
cord-300194-nsp53lv6	13	5	its	-PRON-	PRP$
cord-300194-nsp53lv6	13	6	ability	ability	NN
cord-300194-nsp53lv6	13	7	to	to	TO
cord-300194-nsp53lv6	13	8	bind	bind	VB
cord-300194-nsp53lv6	13	9	to	to	IN
cord-300194-nsp53lv6	13	10	ACE2	ACE2	NNP
cord-300194-nsp53lv6	13	11	,	,	,
cord-300194-nsp53lv6	13	12	due	due	IN
cord-300194-nsp53lv6	13	13	to	to	IN
cord-300194-nsp53lv6	13	14	the	the	DT
cord-300194-nsp53lv6	13	15	burying	burying	NN
cord-300194-nsp53lv6	13	16	of	of	IN
cord-300194-nsp53lv6	13	17	its	-PRON-	PRP$
cord-300194-nsp53lv6	13	18	receptor	receptor	NN
cord-300194-nsp53lv6	13	19	binding	bind	VBG
cord-300194-nsp53lv6	13	20	residues	residue	NNS
cord-300194-nsp53lv6	13	21	.	.	.
cord-300194-nsp53lv6	14	1	Our	-PRON-	PRP$
cord-300194-nsp53lv6	14	2	results	result	NNS
cord-300194-nsp53lv6	14	3	clearly	clearly	RB
cord-300194-nsp53lv6	14	4	show	show	VBP
cord-300194-nsp53lv6	14	5	that	that	IN
cord-300194-nsp53lv6	14	6	there	there	EX
cord-300194-nsp53lv6	14	7	are	be	VBP
cord-300194-nsp53lv6	14	8	active	active	JJ
cord-300194-nsp53lv6	14	9	and	and	CC
cord-300194-nsp53lv6	14	10	inactive	inactive	JJ
cord-300194-nsp53lv6	14	11	states	state	NNS
cord-300194-nsp53lv6	14	12	of	of	IN
cord-300194-nsp53lv6	14	13	the	the	DT
cord-300194-nsp53lv6	14	14	protein	protein	NN
cord-300194-nsp53lv6	14	15	at	at	IN
cord-300194-nsp53lv6	14	16	different	different	JJ
cord-300194-nsp53lv6	14	17	temperatures	temperature	NNS
cord-300194-nsp53lv6	14	18	.	.	.
cord-300194-nsp53lv6	15	1	This	this	DT
cord-300194-nsp53lv6	15	2	would	would	MD
cord-300194-nsp53lv6	15	3	not	not	RB
cord-300194-nsp53lv6	15	4	only	only	RB
cord-300194-nsp53lv6	15	5	prove	prove	VB
cord-300194-nsp53lv6	15	6	beneficial	beneficial	JJ
cord-300194-nsp53lv6	15	7	for	for	IN
cord-300194-nsp53lv6	15	8	understanding	understand	VBG
cord-300194-nsp53lv6	15	9	the	the	DT
cord-300194-nsp53lv6	15	10	fundamental	fundamental	JJ
cord-300194-nsp53lv6	15	11	nature	nature	NN
cord-300194-nsp53lv6	15	12	of	of	IN
cord-300194-nsp53lv6	15	13	the	the	DT
cord-300194-nsp53lv6	15	14	virus	virus	NN
cord-300194-nsp53lv6	15	15	,	,	,
cord-300194-nsp53lv6	15	16	but	but	CC
cord-300194-nsp53lv6	15	17	would	would	MD
cord-300194-nsp53lv6	15	18	be	be	VB
cord-300194-nsp53lv6	15	19	also	also	RB
cord-300194-nsp53lv6	15	20	useful	useful	JJ
cord-300194-nsp53lv6	15	21	in	in	IN
cord-300194-nsp53lv6	15	22	the	the	DT
cord-300194-nsp53lv6	15	23	development	development	NN
cord-300194-nsp53lv6	15	24	of	of	IN
cord-300194-nsp53lv6	15	25	vaccines	vaccine	NNS
cord-300194-nsp53lv6	15	26	and	and	CC
cord-300194-nsp53lv6	15	27	therapeutics	therapeutic	NNS
cord-300194-nsp53lv6	15	28	.	.	.
cord-300194-nsp53lv6	16	1	Graphical	Graphical	NNP
cord-300194-nsp53lv6	16	2	Abstract	Abstract	NNP
cord-300194-nsp53lv6	16	3	Highlights	Highlights	NNPS
cord-300194-nsp53lv6	16	4	Statistical	Statistical	NNP
cord-300194-nsp53lv6	16	5	and	and	CC
cord-300194-nsp53lv6	16	6	epidemiological	epidemiological	JJ
cord-300194-nsp53lv6	16	7	evidence	evidence	NN
cord-300194-nsp53lv6	16	8	show	show	VBP
cord-300194-nsp53lv6	16	9	that	that	IN
cord-300194-nsp53lv6	16	10	external	external	JJ
cord-300194-nsp53lv6	16	11	climatic	climatic	JJ
cord-300194-nsp53lv6	16	12	conditions	condition	NNS
cord-300194-nsp53lv6	16	13	influence	influence	VBP
cord-300194-nsp53lv6	16	14	the	the	DT
cord-300194-nsp53lv6	16	15	SARS	SARS	NNP
cord-300194-nsp53lv6	16	16	-	-	HYPH
cord-300194-nsp53lv6	16	17	CoV	cov	NN
cord-300194-nsp53lv6	16	18	infectivity	infectivity	NN
cord-300194-nsp53lv6	16	19	,	,	,
cord-300194-nsp53lv6	16	20	but	but	CC
cord-300194-nsp53lv6	16	21	we	-PRON-	PRP
cord-300194-nsp53lv6	16	22	still	still	RB
cord-300194-nsp53lv6	16	23	lack	lack	VBP
cord-300194-nsp53lv6	16	24	a	a	DT
cord-300194-nsp53lv6	16	25	molecular	molecular	JJ
cord-300194-nsp53lv6	16	26	level	level	NN
cord-300194-nsp53lv6	16	27	understanding	understanding	NN
cord-300194-nsp53lv6	16	28	of	of	IN
cord-300194-nsp53lv6	16	29	the	the	DT
cord-300194-nsp53lv6	16	30	same	same	JJ
cord-300194-nsp53lv6	16	31	.	.	.
cord-300194-nsp53lv6	17	1	Here	here	RB
cord-300194-nsp53lv6	17	2	,	,	,
cord-300194-nsp53lv6	17	3	we	-PRON-	PRP
cord-300194-nsp53lv6	17	4	study	study	VBP
cord-300194-nsp53lv6	17	5	the	the	DT
cord-300194-nsp53lv6	17	6	influence	influence	NN
cord-300194-nsp53lv6	17	7	of	of	IN
cord-300194-nsp53lv6	17	8	temperature	temperature	NN
cord-300194-nsp53lv6	17	9	on	on	IN
cord-300194-nsp53lv6	17	10	the	the	DT
cord-300194-nsp53lv6	17	11	structure	structure	NN
cord-300194-nsp53lv6	17	12	of	of	IN
cord-300194-nsp53lv6	17	13	the	the	DT
cord-300194-nsp53lv6	17	14	Spike	Spike	NNP
cord-300194-nsp53lv6	17	15	glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	17	16	,	,	,
cord-300194-nsp53lv6	17	17	the	the	DT
cord-300194-nsp53lv6	17	18	outermost	outermost	JJS
cord-300194-nsp53lv6	17	19	structural	structural	JJ
cord-300194-nsp53lv6	17	20	protein	protein	NN
cord-300194-nsp53lv6	17	21	,	,	,
cord-300194-nsp53lv6	17	22	of	of	IN
cord-300194-nsp53lv6	17	23	the	the	DT
cord-300194-nsp53lv6	17	24	virus	virus	NN
cord-300194-nsp53lv6	17	25	which	which	WDT
cord-300194-nsp53lv6	17	26	binds	bind	VBZ
cord-300194-nsp53lv6	17	27	to	to	IN
cord-300194-nsp53lv6	17	28	the	the	DT
cord-300194-nsp53lv6	17	29	human	human	JJ
cord-300194-nsp53lv6	17	30	receptor	receptor	NN
cord-300194-nsp53lv6	17	31	ACE2	ACE2	NNP
cord-300194-nsp53lv6	17	32	.	.	.
cord-300194-nsp53lv6	18	1	Results	result	NNS
cord-300194-nsp53lv6	18	2	show	show	VBP
cord-300194-nsp53lv6	18	3	that	that	IN
cord-300194-nsp53lv6	18	4	the	the	DT
cord-300194-nsp53lv6	18	5	Spike	Spike	NNP
cord-300194-nsp53lv6	18	6	’s	’s	POS
cord-300194-nsp53lv6	18	7	S1	s1	NN
cord-300194-nsp53lv6	18	8	domain	domain	NN
cord-300194-nsp53lv6	18	9	is	be	VBZ
cord-300194-nsp53lv6	18	10	very	very	RB
cord-300194-nsp53lv6	18	11	sensitive	sensitive	JJ
cord-300194-nsp53lv6	18	12	to	to	IN
cord-300194-nsp53lv6	18	13	external	external	JJ
cord-300194-nsp53lv6	18	14	atmospheric	atmospheric	JJ
cord-300194-nsp53lv6	18	15	conditions	condition	NNS
cord-300194-nsp53lv6	18	16	compared	compare	VBN
cord-300194-nsp53lv6	18	17	to	to	IN
cord-300194-nsp53lv6	18	18	the	the	DT
cord-300194-nsp53lv6	18	19	S2	s2	NN
cord-300194-nsp53lv6	18	20	transmembrane	transmembrane	NN
cord-300194-nsp53lv6	18	21	domain	domain	NN
cord-300194-nsp53lv6	18	22	.	.	.
cord-300194-nsp53lv6	19	1	The	the	DT
cord-300194-nsp53lv6	19	2	N	n	CD
cord-300194-nsp53lv6	19	3	-	-	HYPH
cord-300194-nsp53lv6	19	4	terminal	terminal	NN
cord-300194-nsp53lv6	19	5	domain	domain	NN
cord-300194-nsp53lv6	19	6	comprises	comprise	VBZ
cord-300194-nsp53lv6	19	7	of	of	IN
cord-300194-nsp53lv6	19	8	several	several	JJ
cord-300194-nsp53lv6	19	9	solvent	solvent	NN
cord-300194-nsp53lv6	19	10	exposed	expose	VBN
cord-300194-nsp53lv6	19	11	charged	charge	VBN
cord-300194-nsp53lv6	19	12	residues	residue	NNS
cord-300194-nsp53lv6	19	13	that	that	WDT
cord-300194-nsp53lv6	19	14	are	be	VBP
cord-300194-nsp53lv6	19	15	capable	capable	JJ
cord-300194-nsp53lv6	19	16	of	of	IN
cord-300194-nsp53lv6	19	17	binding	bind	VBG
cord-300194-nsp53lv6	19	18	to	to	IN
cord-300194-nsp53lv6	19	19	human	human	JJ
cord-300194-nsp53lv6	19	20	proteins	protein	NNS
cord-300194-nsp53lv6	19	21	.	.	.
cord-300194-nsp53lv6	20	1	The	the	DT
cord-300194-nsp53lv6	20	2	region	region	NN
cord-300194-nsp53lv6	20	3	is	be	VBZ
cord-300194-nsp53lv6	20	4	specifically	specifically	RB
cord-300194-nsp53lv6	20	5	stable	stable	JJ
cord-300194-nsp53lv6	20	6	at	at	IN
cord-300194-nsp53lv6	20	7	temperatures	temperature	NNS
cord-300194-nsp53lv6	20	8	ranging	range	VBG
cord-300194-nsp53lv6	20	9	around	around	IN
cord-300194-nsp53lv6	20	10	10	10	CD
cord-300194-nsp53lv6	20	11	-	-	SYM
cord-300194-nsp53lv6	20	12	30	30	CD
cord-300194-nsp53lv6	20	13	°	°	NN
cord-300194-nsp53lv6	20	14	C.	C.	NNP
cord-300194-nsp53lv6	20	15	The	the	DT
cord-300194-nsp53lv6	20	16	Receptor	Receptor	NNP
cord-300194-nsp53lv6	20	17	Binding	Binding	NNP
cord-300194-nsp53lv6	20	18	Motif	Motif	NNP
cord-300194-nsp53lv6	20	19	adopts	adopt	VBZ
cord-300194-nsp53lv6	20	20	a	a	DT
cord-300194-nsp53lv6	20	21	closed	closed	JJ
cord-300194-nsp53lv6	20	22	conformation	conformation	NN
cord-300194-nsp53lv6	20	23	at	at	IN
cord-300194-nsp53lv6	20	24	40	40	CD
cord-300194-nsp53lv6	20	25	°	°	NN
cord-300194-nsp53lv6	20	26	C	c	NN
cord-300194-nsp53lv6	20	27	and	and	CC
cord-300194-nsp53lv6	20	28	completely	completely	RB
cord-300194-nsp53lv6	20	29	closes	close	VBZ
cord-300194-nsp53lv6	20	30	at	at	IN
cord-300194-nsp53lv6	20	31	higher	high	JJR
cord-300194-nsp53lv6	20	32	temperatures	temperature	NNS
cord-300194-nsp53lv6	20	33	making	make	VBG
cord-300194-nsp53lv6	20	34	it	-PRON-	PRP
cord-300194-nsp53lv6	20	35	unsuitable	unsuitable	JJ
cord-300194-nsp53lv6	20	36	of	of	IN
cord-300194-nsp53lv6	20	37	binding	bind	VBG
cord-300194-nsp53lv6	20	38	to	to	IN
cord-300194-nsp53lv6	20	39	human	human	JJ
cord-300194-nsp53lv6	20	40	receptors	receptor	NNS
cord-300194-nsp53lv6	20	41	Severe	severe	JJ
cord-300194-nsp53lv6	20	42	Acute	acute	JJ
cord-300194-nsp53lv6	20	43	Respiratory	Respiratory	NNP
cord-300194-nsp53lv6	20	44	Syndrome	Syndrome	NNP
cord-300194-nsp53lv6	20	45	Coronavirus	Coronavirus	NNP
cord-300194-nsp53lv6	20	46	2	2	CD
cord-300194-nsp53lv6	20	47	or	or	CC
cord-300194-nsp53lv6	20	48	SARS	SARS	NNP
cord-300194-nsp53lv6	20	49	-	-	HYPH
cord-300194-nsp53lv6	20	50	COV-2	COV-2	NNP
cord-300194-nsp53lv6	20	51	,	,	,
cord-300194-nsp53lv6	20	52	attacks	attack	VBZ
cord-300194-nsp53lv6	20	53	the	the	DT
cord-300194-nsp53lv6	20	54	cells	cell	NNS
cord-300194-nsp53lv6	20	55	of	of	IN
cord-300194-nsp53lv6	20	56	the	the	DT
cord-300194-nsp53lv6	20	57	human	human	JJ
cord-300194-nsp53lv6	20	58	respiratory	respiratory	JJ
cord-300194-nsp53lv6	20	59	system	system	NN
cord-300194-nsp53lv6	20	60	.	.	.
cord-300194-nsp53lv6	21	1	Recent	recent	JJ
cord-300194-nsp53lv6	21	2	studies	study	NNS
cord-300194-nsp53lv6	21	3	have	have	VBP
cord-300194-nsp53lv6	21	4	found	find	VBN
cord-300194-nsp53lv6	21	5	that	that	IN
cord-300194-nsp53lv6	21	6	the	the	DT
cord-300194-nsp53lv6	21	7	virus	virus	NN
cord-300194-nsp53lv6	21	8	also	also	RB
cord-300194-nsp53lv6	21	9	interacts	interact	VBZ
cord-300194-nsp53lv6	21	10	with	with	IN
cord-300194-nsp53lv6	21	11	the	the	DT
cord-300194-nsp53lv6	21	12	cells	cell	NNS
cord-300194-nsp53lv6	21	13	of	of	IN
cord-300194-nsp53lv6	21	14	the	the	DT
cord-300194-nsp53lv6	21	15	digestive	digestive	JJ
cord-300194-nsp53lv6	21	16	system	system	NN
cord-300194-nsp53lv6	21	17	,	,	,
cord-300194-nsp53lv6	21	18	renal	renal	JJ
cord-300194-nsp53lv6	21	19	system	system	NN
cord-300194-nsp53lv6	21	20	,	,	,
cord-300194-nsp53lv6	21	21	liver	liver	NN
cord-300194-nsp53lv6	21	22	,	,	,
cord-300194-nsp53lv6	21	23	pancreas	pancrea	NNS
cord-300194-nsp53lv6	21	24	,	,	,
cord-300194-nsp53lv6	21	25	eyes	eye	NNS
cord-300194-nsp53lv6	21	26	and	and	CC
cord-300194-nsp53lv6	21	27	brain	brain	NN
cord-300194-nsp53lv6	21	28	[	[	-LRB-
cord-300194-nsp53lv6	21	29	1	1	CD
cord-300194-nsp53lv6	21	30	]	]	-RRB-
cord-300194-nsp53lv6	21	31	.	.	.
cord-300194-nsp53lv6	22	1	It	-PRON-	PRP
cord-300194-nsp53lv6	22	2	is	be	VBZ
cord-300194-nsp53lv6	22	3	known	know	VBN
cord-300194-nsp53lv6	22	4	to	to	TO
cord-300194-nsp53lv6	22	5	cause	cause	VB
cord-300194-nsp53lv6	22	6	severe	severe	JJ
cord-300194-nsp53lv6	22	7	sickness	sickness	NN
cord-300194-nsp53lv6	22	8	and	and	CC
cord-300194-nsp53lv6	22	9	is	be	VBZ
cord-300194-nsp53lv6	22	10	fatal	fatal	JJ
cord-300194-nsp53lv6	22	11	in	in	IN
cord-300194-nsp53lv6	22	12	many	many	JJ
cord-300194-nsp53lv6	22	13	cases	case	NNS
cord-300194-nsp53lv6	22	14	[	[	-LRB-
cord-300194-nsp53lv6	22	15	2	2	CD
cord-300194-nsp53lv6	22	16	]	]	-RRB-
cord-300194-nsp53lv6	22	17	.	.	.
cord-300194-nsp53lv6	23	1	It	-PRON-	PRP
cord-300194-nsp53lv6	23	2	is	be	VBZ
cord-300194-nsp53lv6	23	3	believed	believe	VBN
cord-300194-nsp53lv6	23	4	that	that	IN
cord-300194-nsp53lv6	23	5	the	the	DT
cord-300194-nsp53lv6	23	6	virus	virus	NN
cord-300194-nsp53lv6	23	7	originated	originate	VBD
cord-300194-nsp53lv6	23	8	in	in	IN
cord-300194-nsp53lv6	23	9	bats	bat	NNS
cord-300194-nsp53lv6	23	10	,	,	,
cord-300194-nsp53lv6	23	11	which	which	WDT
cord-300194-nsp53lv6	23	12	act	act	VBP
cord-300194-nsp53lv6	23	13	as	as	IN
cord-300194-nsp53lv6	23	14	the	the	DT
cord-300194-nsp53lv6	23	15	natural	natural	JJ
cord-300194-nsp53lv6	23	16	reservoir	reservoir	NN
cord-300194-nsp53lv6	23	17	;	;	:
cord-300194-nsp53lv6	23	18	subsequently	subsequently	RB
cord-300194-nsp53lv6	23	19	it	-PRON-	PRP
cord-300194-nsp53lv6	23	20	got	get	VBD
cord-300194-nsp53lv6	23	21	transmitted	transmit	VBN
cord-300194-nsp53lv6	23	22	to	to	IN
cord-300194-nsp53lv6	23	23	human	human	NN
cord-300194-nsp53lv6	23	24	.	.	.
cord-300194-nsp53lv6	24	1	It	-PRON-	PRP
cord-300194-nsp53lv6	24	2	then	then	RB
cord-300194-nsp53lv6	24	3	gradually	gradually	RB
cord-300194-nsp53lv6	24	4	spread	spread	VBD
cord-300194-nsp53lv6	24	5	across	across	IN
cord-300194-nsp53lv6	24	6	almost	almost	RB
cord-300194-nsp53lv6	24	7	all	all	PDT
cord-300194-nsp53lv6	24	8	the	the	DT
cord-300194-nsp53lv6	24	9	nations	nation	NNS
cord-300194-nsp53lv6	24	10	through	through	IN
cord-300194-nsp53lv6	24	11	aerial	aerial	JJ
cord-300194-nsp53lv6	24	12	transmission	transmission	NN
cord-300194-nsp53lv6	24	13	resulting	result	VBG
cord-300194-nsp53lv6	24	14	in	in	IN
cord-300194-nsp53lv6	24	15	one	one	CD
cord-300194-nsp53lv6	24	16	of	of	IN
cord-300194-nsp53lv6	24	17	the	the	DT
cord-300194-nsp53lv6	24	18	worst	worst	RBS
cord-300194-nsp53lv6	24	19	known	know	VBN
cord-300194-nsp53lv6	24	20	global	global	JJ
cord-300194-nsp53lv6	24	21	pandemic	pandemic	NN
cord-300194-nsp53lv6	24	22	of	of	IN
cord-300194-nsp53lv6	24	23	this	this	DT
cord-300194-nsp53lv6	24	24	century	century	NN
cord-300194-nsp53lv6	24	25	[	[	-LRB-
cord-300194-nsp53lv6	24	26	3	3	CD
cord-300194-nsp53lv6	24	27	]	]	-RRB-
cord-300194-nsp53lv6	24	28	.	.	.
cord-300194-nsp53lv6	25	1	SARS	SARS	NNP
cord-300194-nsp53lv6	25	2	-	-	HYPH
cord-300194-nsp53lv6	25	3	COV-2	COV-2	NNP
cord-300194-nsp53lv6	25	4	is	be	VBZ
cord-300194-nsp53lv6	25	5	one	one	CD
cord-300194-nsp53lv6	25	6	of	of	IN
cord-300194-nsp53lv6	25	7	the	the	DT
cord-300194-nsp53lv6	25	8	seven	seven	CD
cord-300194-nsp53lv6	25	9	forms	form	NNS
cord-300194-nsp53lv6	25	10	of	of	IN
cord-300194-nsp53lv6	25	11	coronaviruses	coronaviruse	NNS
cord-300194-nsp53lv6	25	12	that	that	WDT
cord-300194-nsp53lv6	25	13	affect	affect	VBP
cord-300194-nsp53lv6	25	14	the	the	DT
cord-300194-nsp53lv6	25	15	human	human	JJ
cord-300194-nsp53lv6	25	16	population	population	NN
cord-300194-nsp53lv6	25	17	.	.	.
cord-300194-nsp53lv6	26	1	The	the	DT
cord-300194-nsp53lv6	26	2	other	other	JJ
cord-300194-nsp53lv6	26	3	known	know	VBN
cord-300194-nsp53lv6	26	4	coronaviruses	coronaviruse	NNS
cord-300194-nsp53lv6	26	5	include	include	VBP
cord-300194-nsp53lv6	26	6	HCoV-229E	HCoV-229E	NNP
cord-300194-nsp53lv6	26	7	,	,	,
cord-300194-nsp53lv6	26	8	HCoV	HCoV	NNP
cord-300194-nsp53lv6	26	9	-	-	HYPH
cord-300194-nsp53lv6	26	10	OC43	OC43	NNP
cord-300194-nsp53lv6	26	11	,	,	,
cord-300194-nsp53lv6	26	12	SARS	SARS	NNP
cord-300194-nsp53lv6	26	13	-	-	HYPH
cord-300194-nsp53lv6	26	14	CoV	CoV	NNP
cord-300194-nsp53lv6	26	15	,	,	,
cord-300194-nsp53lv6	26	16	HCoV	HCoV	NNP
cord-300194-nsp53lv6	26	17	-	-	HYPH
cord-300194-nsp53lv6	26	18	NL63	NL63	NNP
cord-300194-nsp53lv6	26	19	,	,	,
cord-300194-nsp53lv6	26	20	HCoV	HCoV	NNP
cord-300194-nsp53lv6	26	21	-	-	HYPH
cord-300194-nsp53lv6	26	22	HKU1	HKU1	NNP
cord-300194-nsp53lv6	26	23	and	and	CC
cord-300194-nsp53lv6	26	24	MERS	MERS	NNP
cord-300194-nsp53lv6	26	25	-	-	HYPH
cord-300194-nsp53lv6	26	26	CoV	CoV	NNP
cord-300194-nsp53lv6	26	27	[	[	-LRB-
cord-300194-nsp53lv6	26	28	4	4	CD
cord-300194-nsp53lv6	26	29	,	,	,
cord-300194-nsp53lv6	26	30	5	5	CD
cord-300194-nsp53lv6	26	31	]	]	-RRB-
cord-300194-nsp53lv6	26	32	.	.	.
cord-300194-nsp53lv6	27	1	Their	-PRON-	PRP$
cord-300194-nsp53lv6	27	2	infection	infection	NN
cord-300194-nsp53lv6	27	3	varies	vary	VBZ
cord-300194-nsp53lv6	27	4	from	from	IN
cord-300194-nsp53lv6	27	5	common	common	JJ
cord-300194-nsp53lv6	27	6	cold	cold	NN
cord-300194-nsp53lv6	27	7	to	to	IN
cord-300194-nsp53lv6	27	8	SARS	SARS	NNP
cord-300194-nsp53lv6	27	9	,	,	,
cord-300194-nsp53lv6	27	10	MERS	MERS	NNP
cord-300194-nsp53lv6	27	11	or	or	CC
cord-300194-nsp53lv6	27	12	Covid19	Covid19	NNP
cord-300194-nsp53lv6	28	1	[	[	-LRB-
cord-300194-nsp53lv6	28	2	5	5	CD
cord-300194-nsp53lv6	28	3	]	]	-RRB-
cord-300194-nsp53lv6	28	4	.	.	.
cord-300194-nsp53lv6	29	1	These	these	DT
cord-300194-nsp53lv6	29	2	viruses	virus	NNS
cord-300194-nsp53lv6	29	3	have	have	VBP
cord-300194-nsp53lv6	29	4	been	be	VBN
cord-300194-nsp53lv6	29	5	observed	observe	VBN
cord-300194-nsp53lv6	29	6	to	to	TO
cord-300194-nsp53lv6	29	7	affect	affect	VB
cord-300194-nsp53lv6	29	8	the	the	DT
cord-300194-nsp53lv6	29	9	human	human	JJ
cord-300194-nsp53lv6	29	10	population	population	NN
cord-300194-nsp53lv6	29	11	predominantly	predominantly	RB
cord-300194-nsp53lv6	29	12	during	during	IN
cord-300194-nsp53lv6	29	13	a	a	DT
cord-300194-nsp53lv6	29	14	particular	particular	JJ
cord-300194-nsp53lv6	29	15	season	season	NN
cord-300194-nsp53lv6	29	16	.	.	.
cord-300194-nsp53lv6	30	1	For	for	IN
cord-300194-nsp53lv6	30	2	instance	instance	NN
cord-300194-nsp53lv6	30	3	,	,	,
cord-300194-nsp53lv6	30	4	the	the	DT
cord-300194-nsp53lv6	30	5	2002	2002	CD
cord-300194-nsp53lv6	30	6	SARS	SARS	NNP
cord-300194-nsp53lv6	30	7	infections	infection	NNS
cord-300194-nsp53lv6	30	8	began	begin	VBD
cord-300194-nsp53lv6	30	9	during	during	IN
cord-300194-nsp53lv6	30	10	the	the	DT
cord-300194-nsp53lv6	30	11	cold	cold	JJ
cord-300194-nsp53lv6	30	12	winters	winter	NNS
cord-300194-nsp53lv6	30	13	of	of	IN
cord-300194-nsp53lv6	30	14	November	November	NNP
cord-300194-nsp53lv6	30	15	and	and	CC
cord-300194-nsp53lv6	30	16	after	after	IN
cord-300194-nsp53lv6	30	17	eight	eight	CD
cord-300194-nsp53lv6	30	18	months	month	NNS
cord-300194-nsp53lv6	30	19	,	,	,
cord-300194-nsp53lv6	30	20	the	the	DT
cord-300194-nsp53lv6	30	21	number	number	NN
cord-300194-nsp53lv6	30	22	of	of	IN
cord-300194-nsp53lv6	30	23	reported	report	VBN
cord-300194-nsp53lv6	30	24	cases	case	NNS
cord-300194-nsp53lv6	30	25	became	become	VBD
cord-300194-nsp53lv6	30	26	almost	almost	RB
cord-300194-nsp53lv6	30	27	negligible	negligible	JJ
cord-300194-nsp53lv6	30	28	[	[	-LRB-
cord-300194-nsp53lv6	30	29	5	5	CD
cord-300194-nsp53lv6	30	30	]	]	-RRB-
cord-300194-nsp53lv6	30	31	.	.	.
cord-300194-nsp53lv6	31	1	Statistics	statistic	NNS
cord-300194-nsp53lv6	31	2	show	show	VBP
cord-300194-nsp53lv6	31	3	that	that	IN
cord-300194-nsp53lv6	31	4	countries	country	NNS
cord-300194-nsp53lv6	31	5	with	with	IN
cord-300194-nsp53lv6	31	6	hot	hot	JJ
cord-300194-nsp53lv6	31	7	and	and	CC
cord-300194-nsp53lv6	31	8	humid	humid	JJ
cord-300194-nsp53lv6	31	9	weather	weather	NN
cord-300194-nsp53lv6	31	10	conditions	condition	NNS
cord-300194-nsp53lv6	31	11	had	have	VBD
cord-300194-nsp53lv6	31	12	lesser	less	JJR
cord-300194-nsp53lv6	31	13	number	number	NN
cord-300194-nsp53lv6	31	14	of	of	IN
cord-300194-nsp53lv6	31	15	infectious	infectious	JJ
cord-300194-nsp53lv6	31	16	cases	case	NNS
cord-300194-nsp53lv6	31	17	of	of	IN
cord-300194-nsp53lv6	31	18	SARS	SARS	NNP
cord-300194-nsp53lv6	31	19	[	[	-LRB-
cord-300194-nsp53lv6	31	20	6	6	CD
cord-300194-nsp53lv6	31	21	]	]	-RRB-
cord-300194-nsp53lv6	31	22	.	.	.
cord-300194-nsp53lv6	32	1	However	however	RB
cord-300194-nsp53lv6	32	2	,	,	,
cord-300194-nsp53lv6	32	3	MERS	MERS	NNP
cord-300194-nsp53lv6	32	4	-	-	HYPH
cord-300194-nsp53lv6	32	5	COV	COV	NNP
cord-300194-nsp53lv6	32	6	,	,	,
cord-300194-nsp53lv6	32	7	which	which	WDT
cord-300194-nsp53lv6	32	8	was	be	VBD
cord-300194-nsp53lv6	32	9	identified	identify	VBN
cord-300194-nsp53lv6	32	10	in	in	IN
cord-300194-nsp53lv6	32	11	Middle	Middle	NNP
cord-300194-nsp53lv6	32	12	East	East	NNP
cord-300194-nsp53lv6	32	13	regions	region	NNS
cord-300194-nsp53lv6	32	14	,	,	,
cord-300194-nsp53lv6	32	15	affected	affect	VBD
cord-300194-nsp53lv6	32	16	individuals	individual	NNS
cord-300194-nsp53lv6	32	17	during	during	IN
cord-300194-nsp53lv6	32	18	the	the	DT
cord-300194-nsp53lv6	32	19	summer	summer	NN
cord-300194-nsp53lv6	32	20	[	[	-LRB-
cord-300194-nsp53lv6	32	21	5	5	CD
cord-300194-nsp53lv6	32	22	]	]	-RRB-
cord-300194-nsp53lv6	32	23	.	.	.
cord-300194-nsp53lv6	33	1	Thus	thus	RB
cord-300194-nsp53lv6	33	2	,	,	,
cord-300194-nsp53lv6	33	3	the	the	DT
cord-300194-nsp53lv6	33	4	disease	disease	NN
cord-300194-nsp53lv6	33	5	epidemiology	epidemiology	NN
cord-300194-nsp53lv6	33	6	suggests	suggest	VBZ
cord-300194-nsp53lv6	33	7	that	that	IN
cord-300194-nsp53lv6	33	8	the	the	DT
cord-300194-nsp53lv6	33	9	virus	virus	NN
cord-300194-nsp53lv6	33	10	is	be	VBZ
cord-300194-nsp53lv6	33	11	found	find	VBN
cord-300194-nsp53lv6	33	12	to	to	TO
cord-300194-nsp53lv6	33	13	be	be	VB
cord-300194-nsp53lv6	33	14	prominent	prominent	JJ
cord-300194-nsp53lv6	33	15	in	in	IN
cord-300194-nsp53lv6	33	16	certain	certain	JJ
cord-300194-nsp53lv6	33	17	climatic	climatic	JJ
cord-300194-nsp53lv6	33	18	conditions	condition	NNS
cord-300194-nsp53lv6	33	19	only	only	RB
cord-300194-nsp53lv6	33	20	.	.	.
cord-300194-nsp53lv6	34	1	The	the	DT
cord-300194-nsp53lv6	34	2	viability	viability	NN
cord-300194-nsp53lv6	34	3	of	of	IN
cord-300194-nsp53lv6	34	4	SARS	SARS	NNP
cord-300194-nsp53lv6	34	5	-	-	HYPH
cord-300194-nsp53lv6	34	6	COV-2	COV-2	NNP
cord-300194-nsp53lv6	34	7	was	be	VBD
cord-300194-nsp53lv6	34	8	measured	measure	VBN
cord-300194-nsp53lv6	34	9	on	on	IN
cord-300194-nsp53lv6	34	10	different	different	JJ
cord-300194-nsp53lv6	34	11	surfaces	surface	NNS
cord-300194-nsp53lv6	34	12	y	y	NNP
cord-300194-nsp53lv6	34	13	hin	hin	NNP
cord-300194-nsp53lv6	34	14	et	et	FW
cord-300194-nsp53lv6	34	15	al	al	NNP
cord-300194-nsp53lv6	34	16	who	who	WP
cord-300194-nsp53lv6	34	17	found	find	VBD
cord-300194-nsp53lv6	34	18	that	that	IN
cord-300194-nsp53lv6	34	19	the	the	DT
cord-300194-nsp53lv6	34	20	virus	virus	NN
cord-300194-nsp53lv6	34	21	droplets	droplet	NNS
cord-300194-nsp53lv6	34	22	survived	survive	VBD
cord-300194-nsp53lv6	34	23	at	at	IN
cord-300194-nsp53lv6	34	24	ut	ut	NNP
cord-300194-nsp53lv6	34	25	qui	qui	NNP
cord-300194-nsp53lv6	34	26	kly	kly	NNP
cord-300194-nsp53lv6	34	27	dea	dea	NNP
cord-300194-nsp53lv6	34	28	tivated	tivate	VBN
cord-300194-nsp53lv6	34	29	at	at	IN
cord-300194-nsp53lv6	34	30	elevated	elevated	JJ
cord-300194-nsp53lv6	34	31	temperatures	temperature	NNS
cord-300194-nsp53lv6	34	32	of	of	IN
cord-300194-nsp53lv6	34	33	5	5	CD
cord-300194-nsp53lv6	34	34	[	[	-LRB-
cord-300194-nsp53lv6	34	35	7	7	CD
cord-300194-nsp53lv6	34	36	]	]	-RRB-
cord-300194-nsp53lv6	34	37	.	.	.
cord-300194-nsp53lv6	35	1	Smooth	smooth	JJ
cord-300194-nsp53lv6	35	2	surfaces	surface	NNS
cord-300194-nsp53lv6	35	3	,	,	,
cord-300194-nsp53lv6	35	4	plastics	plastic	NNS
cord-300194-nsp53lv6	35	5	and	and	CC
cord-300194-nsp53lv6	35	6	iron	iron	NN
cord-300194-nsp53lv6	35	7	show	show	VBP
cord-300194-nsp53lv6	35	8	greater	great	JJR
cord-300194-nsp53lv6	35	9	viability	viability	NN
cord-300194-nsp53lv6	35	10	of	of	IN
cord-300194-nsp53lv6	35	11	the	the	DT
cord-300194-nsp53lv6	35	12	virus	virus	NN
cord-300194-nsp53lv6	35	13	compared	compare	VBN
cord-300194-nsp53lv6	35	14	to	to	IN
cord-300194-nsp53lv6	35	15	that	that	DT
cord-300194-nsp53lv6	35	16	of	of	IN
cord-300194-nsp53lv6	35	17	paper	paper	NN
cord-300194-nsp53lv6	35	18	,	,	,
cord-300194-nsp53lv6	35	19	tissue	tissue	NN
cord-300194-nsp53lv6	35	20	,	,	,
cord-300194-nsp53lv6	35	21	wood	wood	NN
cord-300194-nsp53lv6	35	22	or	or	CC
cord-300194-nsp53lv6	35	23	cloth	cloth	NN
cord-300194-nsp53lv6	35	24	.	.	.
cord-300194-nsp53lv6	36	1	Surgical	surgical	JJ
cord-300194-nsp53lv6	36	2	masks	mask	NNS
cord-300194-nsp53lv6	36	3	had	have	VBD
cord-300194-nsp53lv6	36	4	detectable	detectable	JJ
cord-300194-nsp53lv6	36	5	viruses	virus	NNS
cord-300194-nsp53lv6	36	6	even	even	RB
cord-300194-nsp53lv6	36	7	on	on	IN
cord-300194-nsp53lv6	36	8	7	7	CD
cord-300194-nsp53lv6	36	9	th	th	XX
cord-300194-nsp53lv6	36	10	day	day	NN
cord-300194-nsp53lv6	36	11	[	[	-LRB-
cord-300194-nsp53lv6	36	12	8	8	CD
cord-300194-nsp53lv6	36	13	,	,	,
cord-300194-nsp53lv6	36	14	9	9	CD
cord-300194-nsp53lv6	36	15	]	]	-RRB-
cord-300194-nsp53lv6	36	16	.	.	.
cord-300194-nsp53lv6	37	1	Soaps	soap	NNS
cord-300194-nsp53lv6	37	2	and	and	CC
cord-300194-nsp53lv6	37	3	disinfectants	disinfectant	NNS
cord-300194-nsp53lv6	37	4	which	which	WDT
cord-300194-nsp53lv6	37	5	disintegrate	disintegrate	VBP
cord-300194-nsp53lv6	37	6	the	the	DT
cord-300194-nsp53lv6	37	7	virus	virus	NN
cord-300194-nsp53lv6	37	8	membrane	membrane	NN
cord-300194-nsp53lv6	37	9	and	and	CC
cord-300194-nsp53lv6	37	10	structural	structural	JJ
cord-300194-nsp53lv6	37	11	proteins	protein	NNS
cord-300194-nsp53lv6	37	12	are	be	VBP
cord-300194-nsp53lv6	37	13	a	a	DT
cord-300194-nsp53lv6	37	14	potent	potent	JJ
cord-300194-nsp53lv6	37	15	example	example	NN
cord-300194-nsp53lv6	37	16	of	of	IN
cord-300194-nsp53lv6	37	17	how	how	WRB
cord-300194-nsp53lv6	37	18	the	the	DT
cord-300194-nsp53lv6	37	19	modulation	modulation	NN
cord-300194-nsp53lv6	37	20	of	of	IN
cord-300194-nsp53lv6	37	21	atmospheric	atmospheric	JJ
cord-300194-nsp53lv6	37	22	conditions	condition	NNS
cord-300194-nsp53lv6	37	23	can	can	MD
cord-300194-nsp53lv6	37	24	affect	affect	VB
cord-300194-nsp53lv6	37	25	the	the	DT
cord-300194-nsp53lv6	37	26	virus	virus	NN
cord-300194-nsp53lv6	37	27	viability	viability	NN
cord-300194-nsp53lv6	37	28	.	.	.
cord-300194-nsp53lv6	38	1	Statistical	statistical	JJ
cord-300194-nsp53lv6	38	2	reports	report	NNS
cord-300194-nsp53lv6	38	3	by	by	IN
cord-300194-nsp53lv6	38	4	Cai	Cai	NNP
cord-300194-nsp53lv6	38	5	et	et	NNP
cord-300194-nsp53lv6	38	6	.	.	.
cord-300194-nsp53lv6	39	1	al	al	NNP
cord-300194-nsp53lv6	39	2	.	.	.
cord-300194-nsp53lv6	40	1	,	,	,
cord-300194-nsp53lv6	40	2	and	and	CC
cord-300194-nsp53lv6	40	3	several	several	JJ
cord-300194-nsp53lv6	40	4	others	other	NNS
cord-300194-nsp53lv6	40	5	had	have	VBD
cord-300194-nsp53lv6	40	6	shown	show	VBN
cord-300194-nsp53lv6	40	7	that	that	IN
cord-300194-nsp53lv6	40	8	tropical	tropical	JJ
cord-300194-nsp53lv6	40	9	countries	country	NNS
cord-300194-nsp53lv6	40	10	like	like	IN
cord-300194-nsp53lv6	40	11	Malaysia	Malaysia	NNP
cord-300194-nsp53lv6	40	12	,	,	,
cord-300194-nsp53lv6	40	13	Indonesia	Indonesia	NNP
cord-300194-nsp53lv6	40	14	or	or	CC
cord-300194-nsp53lv6	40	15	Thailand	Thailand	NNP
cord-300194-nsp53lv6	40	16	with	with	IN
cord-300194-nsp53lv6	40	17	high	high	JJ
cord-300194-nsp53lv6	40	18	temperature	temperature	NN
cord-300194-nsp53lv6	40	19	and	and	CC
cord-300194-nsp53lv6	40	20	high	high	JJ
cord-300194-nsp53lv6	40	21	relative	relative	JJ
cord-300194-nsp53lv6	40	22	humidity	humidity	NN
cord-300194-nsp53lv6	40	23	did	do	VBD
cord-300194-nsp53lv6	40	24	not	not	RB
cord-300194-nsp53lv6	40	25	have	have	VB
cord-300194-nsp53lv6	40	26	major	major	JJ
cord-300194-nsp53lv6	40	27	community	community	NN
cord-300194-nsp53lv6	40	28	outbreaks	outbreak	NNS
cord-300194-nsp53lv6	40	29	of	of	IN
cord-300194-nsp53lv6	40	30	SARS	SARS	NNP
cord-300194-nsp53lv6	40	31	[	[	-LRB-
cord-300194-nsp53lv6	40	32	6	6	CD
cord-300194-nsp53lv6	40	33	,	,	,
cord-300194-nsp53lv6	40	34	[	[	-LRB-
cord-300194-nsp53lv6	40	35	10	10	CD
cord-300194-nsp53lv6	40	36	]	]	-RRB-
cord-300194-nsp53lv6	40	37	[	[	-LRB-
cord-300194-nsp53lv6	40	38	11	11	CD
cord-300194-nsp53lv6	40	39	]	]	-RRB-
cord-300194-nsp53lv6	40	40	.	.	.
cord-300194-nsp53lv6	41	1	Although	although	IN
cord-300194-nsp53lv6	41	2	viruses	virus	NNS
cord-300194-nsp53lv6	41	3	can	can	MD
cord-300194-nsp53lv6	41	4	not	not	RB
cord-300194-nsp53lv6	41	5	be	be	VB
cord-300194-nsp53lv6	41	6	killed	kill	VBN
cord-300194-nsp53lv6	41	7	like	like	IN
cord-300194-nsp53lv6	41	8	bacteria	bacteria	NNS
cord-300194-nsp53lv6	41	9	by	by	IN
cord-300194-nsp53lv6	41	10	autoclaving	autoclave	VBG
cord-300194-nsp53lv6	41	11	,	,	,
cord-300194-nsp53lv6	41	12	temperature	temperature	NN
cord-300194-nsp53lv6	41	13	sensitivity	sensitivity	NN
cord-300194-nsp53lv6	41	14	of	of	IN
cord-300194-nsp53lv6	41	15	virus	virus	NN
cord-300194-nsp53lv6	41	16	have	have	VBP
cord-300194-nsp53lv6	41	17	been	be	VBN
cord-300194-nsp53lv6	41	18	reported	report	VBN
cord-300194-nsp53lv6	41	19	several	several	JJ
cord-300194-nsp53lv6	41	20	times	time	NNS
cord-300194-nsp53lv6	41	21	in	in	IN
cord-300194-nsp53lv6	41	22	the	the	DT
cord-300194-nsp53lv6	41	23	past	past	NN
cord-300194-nsp53lv6	41	24	.	.	.
cord-300194-nsp53lv6	42	1	Seasonal	Seasonal	NNP
cord-300194-nsp53lv6	42	2	Rhinoviruses	Rhinoviruses	NNP
cord-300194-nsp53lv6	42	3	ould	ould	MD
cord-300194-nsp53lv6	42	4	not	not	RB
cord-300194-nsp53lv6	42	5	repli	repli	VB
cord-300194-nsp53lv6	42	6	ate	eat	VBD
cord-300194-nsp53lv6	42	7	at	at	IN
cord-300194-nsp53lv6	42	8	C	c	NN
cord-300194-nsp53lv6	42	9	whereas	whereas	IN
cord-300194-nsp53lv6	42	10	-C	-C	VBZ
cord-300194-nsp53lv6	42	11	is	be	VBZ
cord-300194-nsp53lv6	42	12	ideal	ideal	JJ
cord-300194-nsp53lv6	42	13	for	for	IN
cord-300194-nsp53lv6	42	14	their	-PRON-	PRP$
cord-300194-nsp53lv6	42	15	survival	survival	NN
cord-300194-nsp53lv6	42	16	in	in	IN
cord-300194-nsp53lv6	42	17	nasal	nasal	NN
cord-300194-nsp53lv6	42	18	cavity	cavity	NN
cord-300194-nsp53lv6	42	19	[	[	-LRB-
cord-300194-nsp53lv6	42	20	12	12	CD
cord-300194-nsp53lv6	42	21	nfluenza	nfluenza	NNP
cord-300194-nsp53lv6	42	22	was	be	VBD
cord-300194-nsp53lv6	42	23	found	find	VBN
cord-300194-nsp53lv6	42	24	to	to	IN
cord-300194-nsp53lv6	42	25	e	e	NNP
cord-300194-nsp53lv6	42	26	effe	effe	NNP
cord-300194-nsp53lv6	42	27	tive	tive	NNP
cord-300194-nsp53lv6	42	28	at	at	IN
cord-300194-nsp53lv6	42	29	a	a	DT
cord-300194-nsp53lv6	42	30	temperature	temperature	NN
cord-300194-nsp53lv6	42	31	around	around	IN
cord-300194-nsp53lv6	42	32	C	C	NNP
cord-300194-nsp53lv6	42	33	whereas	whereas	IN
cord-300194-nsp53lv6	42	34	higher	high	JJR
cord-300194-nsp53lv6	42	35	temperatures	temperature	NNS
cord-300194-nsp53lv6	42	36	of	of	IN
cord-300194-nsp53lv6	42	37	1	1	CD
cord-300194-nsp53lv6	42	38	C	c	NN
cord-300194-nsp53lv6	42	39	resulted	result	VBD
cord-300194-nsp53lv6	42	40	in	in	IN
cord-300194-nsp53lv6	42	41	clumping	clumping	NN
cord-300194-nsp53lv6	42	42	of	of	IN
cord-300194-nsp53lv6	42	43	viruses	virus	NNS
cord-300194-nsp53lv6	42	44	on	on	IN
cord-300194-nsp53lv6	42	45	cell	cell	NN
cord-300194-nsp53lv6	42	46	surfaces	surface	NNS
cord-300194-nsp53lv6	42	47	[	[	-LRB-
cord-300194-nsp53lv6	42	48	13	13	CD
cord-300194-nsp53lv6	42	49	,	,	,
cord-300194-nsp53lv6	42	50	14	14	CD
cord-300194-nsp53lv6	42	51	,	,	,
cord-300194-nsp53lv6	42	52	15	15	CD
cord-300194-nsp53lv6	42	53	]	]	-RRB-
cord-300194-nsp53lv6	42	54	.	.	.
cord-300194-nsp53lv6	43	1	Similarly	similarly	RB
cord-300194-nsp53lv6	43	2	,	,	,
cord-300194-nsp53lv6	43	3	the	the	DT
cord-300194-nsp53lv6	43	4	viability	viability	NN
cord-300194-nsp53lv6	43	5	of	of	IN
cord-300194-nsp53lv6	43	6	SARS	SARS	NNP
cord-300194-nsp53lv6	43	7	virus	virus	NN
cord-300194-nsp53lv6	43	8	that	that	WDT
cord-300194-nsp53lv6	43	9	persisted	persist	VBD
cord-300194-nsp53lv6	43	10	for	for	IN
cord-300194-nsp53lv6	43	11	5	5	CD
cord-300194-nsp53lv6	43	12	days	day	NNS
cord-300194-nsp53lv6	43	13	at	at	IN
cord-300194-nsp53lv6	43	14	temperatures	temperature	NNS
cord-300194-nsp53lv6	43	15	ranging	range	VBG
cord-300194-nsp53lv6	43	16	etween	etween	JJ
cord-300194-nsp53lv6	43	17	-C	-C	VBZ
cord-300194-nsp53lv6	43	18	andhumidity	andhumidity	NN
cord-300194-nsp53lv6	43	19	was	be	VBD
cord-300194-nsp53lv6	43	20	lost	lose	VBN
cord-300194-nsp53lv6	43	21	when	when	WRB
cord-300194-nsp53lv6	43	22	the	the	DT
cord-300194-nsp53lv6	43	23	temperature	temperature	NN
cord-300194-nsp53lv6	43	24	was	be	VBD
cord-300194-nsp53lv6	43	25	raised	raise	VBN
cord-300194-nsp53lv6	43	26	to	to	IN
cord-300194-nsp53lv6	43	27	C	C	NNP
cord-300194-nsp53lv6	43	28	and	and	CC
cord-300194-nsp53lv6	43	29	95	95	CD
cord-300194-nsp53lv6	43	30	%	%	NN
cord-300194-nsp53lv6	43	31	humidity	humidity	NN
cord-300194-nsp53lv6	43	32	[	[	-LRB-
cord-300194-nsp53lv6	43	33	6	6	CD
cord-300194-nsp53lv6	43	34	]	]	-RRB-
cord-300194-nsp53lv6	43	35	.	.	.
cord-300194-nsp53lv6	44	1	When	when	WRB
cord-300194-nsp53lv6	44	2	the	the	DT
cord-300194-nsp53lv6	44	3	virus	virus	NN
cord-300194-nsp53lv6	44	4	is	be	VBZ
cord-300194-nsp53lv6	44	5	exposed	expose	VBN
cord-300194-nsp53lv6	44	6	to	to	IN
cord-300194-nsp53lv6	44	7	different	different	JJ
cord-300194-nsp53lv6	44	8	temperature	temperature	NN
cord-300194-nsp53lv6	44	9	conditions	condition	NNS
cord-300194-nsp53lv6	44	10	,	,	,
cord-300194-nsp53lv6	44	11	the	the	DT
cord-300194-nsp53lv6	44	12	initial	initial	JJ
cord-300194-nsp53lv6	44	13	interactions	interaction	NNS
cord-300194-nsp53lv6	44	14	of	of	IN
cord-300194-nsp53lv6	44	15	the	the	DT
cord-300194-nsp53lv6	44	16	atmosphere	atmosphere	NN
cord-300194-nsp53lv6	44	17	occur	occur	VBP
cord-300194-nsp53lv6	44	18	with	with	IN
cord-300194-nsp53lv6	44	19	the	the	DT
cord-300194-nsp53lv6	44	20	structural	structural	JJ
cord-300194-nsp53lv6	44	21	proteins	protein	NNS
cord-300194-nsp53lv6	44	22	.	.	.
cord-300194-nsp53lv6	45	1	There	there	EX
cord-300194-nsp53lv6	45	2	are	be	VBP
cord-300194-nsp53lv6	45	3	four	four	CD
cord-300194-nsp53lv6	45	4	major	major	JJ
cord-300194-nsp53lv6	45	5	structural	structural	JJ
cord-300194-nsp53lv6	45	6	proteins	protein	NNS
cord-300194-nsp53lv6	45	7	present	present	JJ
cord-300194-nsp53lv6	45	8	on	on	IN
cord-300194-nsp53lv6	45	9	the	the	DT
cord-300194-nsp53lv6	45	10	virus	virus	NN
cord-300194-nsp53lv6	45	11	,	,	,
cord-300194-nsp53lv6	45	12	the	the	DT
cord-300194-nsp53lv6	45	13	Spike	Spike	NNP
cord-300194-nsp53lv6	45	14	glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	45	15	,	,	,
cord-300194-nsp53lv6	45	16	the	the	DT
cord-300194-nsp53lv6	45	17	Envelope	Envelope	NNP
cord-300194-nsp53lv6	45	18	protein	protein	NN
cord-300194-nsp53lv6	45	19	,	,	,
cord-300194-nsp53lv6	45	20	the	the	DT
cord-300194-nsp53lv6	45	21	Membrane	Membrane	NNP
cord-300194-nsp53lv6	45	22	protein	protein	NN
cord-300194-nsp53lv6	45	23	and	and	CC
cord-300194-nsp53lv6	45	24	the	the	DT
cord-300194-nsp53lv6	45	25	Nucleocapsid	Nucleocapsid	NNP
cord-300194-nsp53lv6	45	26	.	.	.
cord-300194-nsp53lv6	46	1	Each	each	DT
cord-300194-nsp53lv6	46	2	of	of	IN
cord-300194-nsp53lv6	46	3	the	the	DT
cord-300194-nsp53lv6	46	4	proteins	protein	NNS
cord-300194-nsp53lv6	46	5	performs	perform	VBZ
cord-300194-nsp53lv6	46	6	specific	specific	JJ
cord-300194-nsp53lv6	46	7	functions	function	NNS
cord-300194-nsp53lv6	46	8	in	in	IN
cord-300194-nsp53lv6	46	9	receptor	receptor	NN
cord-300194-nsp53lv6	46	10	binding	binding	NN
cord-300194-nsp53lv6	46	11	,	,	,
cord-300194-nsp53lv6	46	12	viral	viral	JJ
cord-300194-nsp53lv6	46	13	assembly	assembly	NN
cord-300194-nsp53lv6	46	14	and	and	CC
cord-300194-nsp53lv6	46	15	genome	genome	NN
cord-300194-nsp53lv6	46	16	release	release	NN
cord-300194-nsp53lv6	46	17	[	[	-LRB-
cord-300194-nsp53lv6	46	18	16	16	CD
cord-300194-nsp53lv6	46	19	]	]	-RRB-
cord-300194-nsp53lv6	46	20	.	.	.
cord-300194-nsp53lv6	47	1	One	one	CD
cord-300194-nsp53lv6	47	2	of	of	IN
cord-300194-nsp53lv6	47	3	the	the	DT
cord-300194-nsp53lv6	47	4	first	first	JJ
cord-300194-nsp53lv6	47	5	and	and	CC
cord-300194-nsp53lv6	47	6	largest	large	JJS
cord-300194-nsp53lv6	47	7	structural	structural	JJ
cord-300194-nsp53lv6	47	8	proteins	protein	NNS
cord-300194-nsp53lv6	47	9	of	of	IN
cord-300194-nsp53lv6	47	10	the	the	DT
cord-300194-nsp53lv6	47	11	Coronavirus	Coronavirus	NNP
cord-300194-nsp53lv6	47	12	is	be	VBZ
cord-300194-nsp53lv6	47	13	the	the	DT
cord-300194-nsp53lv6	47	14	Spike	Spike	NNP
cord-300194-nsp53lv6	47	15	glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	47	16	[	[	-LRB-
cord-300194-nsp53lv6	47	17	17	17	CD
cord-300194-nsp53lv6	47	18	]	]	-RRB-
cord-300194-nsp53lv6	47	19	.	.	.
cord-300194-nsp53lv6	48	1	The	the	DT
cord-300194-nsp53lv6	48	2	protein	protein	NN
cord-300194-nsp53lv6	48	3	exists	exist	VBZ
cord-300194-nsp53lv6	48	4	as	as	IN
cord-300194-nsp53lv6	48	5	a	a	DT
cord-300194-nsp53lv6	48	6	homotrimer	homotrimer	NN
cord-300194-nsp53lv6	48	7	where	where	WRB
cord-300194-nsp53lv6	48	8	each	each	DT
cord-300194-nsp53lv6	48	9	monomer	monomer	NN
cord-300194-nsp53lv6	48	10	consists	consist	VBZ
cord-300194-nsp53lv6	48	11	of	of	IN
cord-300194-nsp53lv6	48	12	1273	1273	CD
cord-300194-nsp53lv6	48	13	amino	amino	NN
cord-300194-nsp53lv6	48	14	acid	acid	NN
cord-300194-nsp53lv6	48	15	residues	residue	NNS
cord-300194-nsp53lv6	48	16	(	(	-LRB-
cord-300194-nsp53lv6	48	17	Figure	figure	NN
cord-300194-nsp53lv6	48	18	1	1	CD
cord-300194-nsp53lv6	48	19	)	)	-RRB-
cord-300194-nsp53lv6	48	20	and	and	CC
cord-300194-nsp53lv6	48	21	is	be	VBZ
cord-300194-nsp53lv6	48	22	intertwined	intertwine	VBN
cord-300194-nsp53lv6	48	23	with	with	IN
cord-300194-nsp53lv6	48	24	each	each	DT
cord-300194-nsp53lv6	48	25	other	other	JJ
cord-300194-nsp53lv6	48	26	.	.	.
cord-300194-nsp53lv6	49	1	Each	each	DT
cord-300194-nsp53lv6	49	2	monomer	monomer	NN
cord-300194-nsp53lv6	49	3	has	have	VBZ
cord-300194-nsp53lv6	49	4	two	two	CD
cord-300194-nsp53lv6	49	5	domains	domain	NNS
cord-300194-nsp53lv6	49	6	,	,	,
cord-300194-nsp53lv6	49	7	namely	namely	RB
cord-300194-nsp53lv6	49	8	S1	S1	NNP
cord-300194-nsp53lv6	49	9	and	and	CC
cord-300194-nsp53lv6	49	10	S2	S2	NNP
cord-300194-nsp53lv6	49	11	[	[	-LRB-
cord-300194-nsp53lv6	49	12	18	18	CD
cord-300194-nsp53lv6	49	13	]	]	-RRB-
cord-300194-nsp53lv6	49	14	.	.	.
cord-300194-nsp53lv6	50	1	The	the	DT
cord-300194-nsp53lv6	50	2	S1	s1	NN
cord-300194-nsp53lv6	50	3	and	and	CC
cord-300194-nsp53lv6	50	4	S2	s2	NN
cord-300194-nsp53lv6	50	5	domains	domain	NNS
cord-300194-nsp53lv6	50	6	are	be	VBP
cord-300194-nsp53lv6	50	7	cleaved	cleave	VBN
cord-300194-nsp53lv6	50	8	at	at	IN
cord-300194-nsp53lv6	50	9	6	6	CD
cord-300194-nsp53lv6	50	10	a	a	DT
cord-300194-nsp53lv6	50	11	furin	furin	NN
cord-300194-nsp53lv6	50	12	site	site	NN
cord-300194-nsp53lv6	50	13	by	by	IN
cord-300194-nsp53lv6	50	14	a	a	DT
cord-300194-nsp53lv6	50	15	host	host	NN
cord-300194-nsp53lv6	50	16	cell	cell	NN
cord-300194-nsp53lv6	50	17	protease	protease	NN
cord-300194-nsp53lv6	50	18	[	[	-LRB-
cord-300194-nsp53lv6	50	19	18	18	CD
cord-300194-nsp53lv6	50	20	,	,	,
cord-300194-nsp53lv6	50	21	19	19	CD
cord-300194-nsp53lv6	50	22	]	]	-RRB-
cord-300194-nsp53lv6	50	23	.	.	.
cord-300194-nsp53lv6	51	1	The	the	DT
cord-300194-nsp53lv6	51	2	S1	s1	NN
cord-300194-nsp53lv6	51	3	domain	domain	NN
cord-300194-nsp53lv6	51	4	lies	lie	VBZ
cord-300194-nsp53lv6	51	5	predominantly	predominantly	RB
cord-300194-nsp53lv6	51	6	above	above	IN
cord-300194-nsp53lv6	51	7	the	the	DT
cord-300194-nsp53lv6	51	8	lipid	lipid	NN
cord-300194-nsp53lv6	51	9	bilayer	bilayer	NN
cord-300194-nsp53lv6	51	10	.	.	.
cord-300194-nsp53lv6	52	1	The	the	DT
cord-300194-nsp53lv6	52	2	S2	S2	NNP
cord-300194-nsp53lv6	52	3	domain	domain	NN
cord-300194-nsp53lv6	52	4	,	,	,
cord-300194-nsp53lv6	52	5	which	which	WDT
cord-300194-nsp53lv6	52	6	is	be	VBZ
cord-300194-nsp53lv6	52	7	a	a	DT
cord-300194-nsp53lv6	52	8	class	class	NN
cord-300194-nsp53lv6	52	9	I	-PRON-	PRP
cord-300194-nsp53lv6	52	10	transmembrane	transmembrane	NN
cord-300194-nsp53lv6	52	11	domain	domain	NN
cord-300194-nsp53lv6	52	12	,	,	,
cord-300194-nsp53lv6	52	13	travels	travel	VBZ
cord-300194-nsp53lv6	52	14	across	across	IN
cord-300194-nsp53lv6	52	15	the	the	DT
cord-300194-nsp53lv6	52	16	bilayer	bilayer	NN
cord-300194-nsp53lv6	52	17	and	and	CC
cord-300194-nsp53lv6	52	18	ends	end	NNS
cord-300194-nsp53lv6	52	19	towards	towards	IN
cord-300194-nsp53lv6	52	20	the	the	DT
cord-300194-nsp53lv6	52	21	inner	inner	JJ
cord-300194-nsp53lv6	52	22	side	side	NN
cord-300194-nsp53lv6	52	23	of	of	IN
cord-300194-nsp53lv6	52	24	the	the	DT
cord-300194-nsp53lv6	52	25	lipid	lipid	NN
cord-300194-nsp53lv6	52	26	membrane	membrane	NN
cord-300194-nsp53lv6	52	27	[	[	-LRB-
cord-300194-nsp53lv6	52	28	18	18	CD
cord-300194-nsp53lv6	52	29	]	]	-RRB-
cord-300194-nsp53lv6	52	30	.	.	.
cord-300194-nsp53lv6	53	1	Figure	figure	NN
cord-300194-nsp53lv6	53	2	1	1	CD
cord-300194-nsp53lv6	53	3	shows	show	VBZ
cord-300194-nsp53lv6	53	4	the	the	DT
cord-300194-nsp53lv6	53	5	two	two	CD
cord-300194-nsp53lv6	53	6	domains	domain	NNS
cord-300194-nsp53lv6	53	7	of	of	IN
cord-300194-nsp53lv6	53	8	the	the	DT
cord-300194-nsp53lv6	53	9	Spike	Spike	NNP
cord-300194-nsp53lv6	53	10	glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	53	11	.	.	.
cord-300194-nsp53lv6	54	1	The	the	DT
cord-300194-nsp53lv6	54	2	S1	s1	NN
cord-300194-nsp53lv6	54	3	domain	domain	NN
cord-300194-nsp53lv6	54	4	comprises	comprise	VBZ
cord-300194-nsp53lv6	54	5	of	of	IN
cord-300194-nsp53lv6	54	6	mostly	mostly	RB
cord-300194-nsp53lv6	54	7	beta	beta	JJ
cord-300194-nsp53lv6	54	8	pleated	pleated	JJ
cord-300194-nsp53lv6	54	9	sheets	sheet	NNS
cord-300194-nsp53lv6	54	10	.	.	.
cord-300194-nsp53lv6	55	1	It	-PRON-	PRP
cord-300194-nsp53lv6	55	2	can	can	MD
cord-300194-nsp53lv6	55	3	be	be	VB
cord-300194-nsp53lv6	55	4	further	further	RB
cord-300194-nsp53lv6	55	5	classified	classify	VBN
cord-300194-nsp53lv6	55	6	into	into	IN
cord-300194-nsp53lv6	55	7	Receptor	Receptor	NNP
cord-300194-nsp53lv6	55	8	Binding	Binding	NNP
cord-300194-nsp53lv6	55	9	domain	domain	NN
cord-300194-nsp53lv6	55	10	(	(	-LRB-
cord-300194-nsp53lv6	55	11	RBD	RBD	NNP
cord-300194-nsp53lv6	55	12	)	)	-RRB-
cord-300194-nsp53lv6	55	13	and	and	CC
cord-300194-nsp53lv6	55	14	N	n	CD
cord-300194-nsp53lv6	55	15	-	-	HYPH
cord-300194-nsp53lv6	55	16	terminal	terminal	NN
cord-300194-nsp53lv6	55	17	Domain	domain	NN
cord-300194-nsp53lv6	55	18	(	(	-LRB-
cord-300194-nsp53lv6	55	19	NTD	NTD	NNP
cord-300194-nsp53lv6	55	20	)	)	-RRB-
cord-300194-nsp53lv6	55	21	.	.	.
cord-300194-nsp53lv6	56	1	The	the	DT
cord-300194-nsp53lv6	56	2	RBD	RBD	NNP
cord-300194-nsp53lv6	56	3	binds	bind	VBZ
cord-300194-nsp53lv6	56	4	to	to	IN
cord-300194-nsp53lv6	56	5	Angiotensin	Angiotensin	NNP
cord-300194-nsp53lv6	56	6	Converting	Converting	NNP
cord-300194-nsp53lv6	56	7	Enzyme	Enzyme	NNP
cord-300194-nsp53lv6	56	8	2	2	CD
cord-300194-nsp53lv6	57	1	(	(	-LRB-
cord-300194-nsp53lv6	57	2	ACE	ace	NN
cord-300194-nsp53lv6	57	3	2	2	CD
cord-300194-nsp53lv6	57	4	)	)	-RRB-
cord-300194-nsp53lv6	57	5	on	on	IN
cord-300194-nsp53lv6	57	6	the	the	DT
cord-300194-nsp53lv6	57	7	host	host	NN
cord-300194-nsp53lv6	57	8	cells	cell	NNS
cord-300194-nsp53lv6	57	9	[	[	-LRB-
cord-300194-nsp53lv6	57	10	20	20	CD
cord-300194-nsp53lv6	57	11	]	]	-RRB-
cord-300194-nsp53lv6	57	12	.	.	.
cord-300194-nsp53lv6	58	1	It	-PRON-	PRP
cord-300194-nsp53lv6	58	2	lies	lie	VBZ
cord-300194-nsp53lv6	58	3	on	on	IN
cord-300194-nsp53lv6	58	4	the	the	DT
cord-300194-nsp53lv6	58	5	top	top	NN
cord-300194-nsp53lv6	58	6	of	of	IN
cord-300194-nsp53lv6	58	7	the	the	DT
cord-300194-nsp53lv6	58	8	complex	complex	NN
cord-300194-nsp53lv6	58	9	,	,	,
cord-300194-nsp53lv6	58	10	where	where	WRB
cord-300194-nsp53lv6	58	11	around	around	RB
cord-300194-nsp53lv6	58	12	14	14	CD
cord-300194-nsp53lv6	58	13	residues	residue	NNS
cord-300194-nsp53lv6	58	14	from	from	IN
cord-300194-nsp53lv6	58	15	the	the	DT
cord-300194-nsp53lv6	58	16	RBD	RBD	NNP
cord-300194-nsp53lv6	58	17	domain	domain	NN
cord-300194-nsp53lv6	58	18	bind	bind	NN
cord-300194-nsp53lv6	58	19	to	to	IN
cord-300194-nsp53lv6	58	20	the	the	DT
cord-300194-nsp53lv6	58	21	ACE2	ACE2	NNP
cord-300194-nsp53lv6	58	22	receptor	receptor	NN
cord-300194-nsp53lv6	58	23	on	on	IN
cord-300194-nsp53lv6	58	24	the	the	DT
cord-300194-nsp53lv6	58	25	host	host	NN
cord-300194-nsp53lv6	58	26	protein	protein	NN
cord-300194-nsp53lv6	58	27	[	[	-LRB-
cord-300194-nsp53lv6	58	28	21	21	CD
cord-300194-nsp53lv6	58	29	,	,	,
cord-300194-nsp53lv6	58	30	22	22	CD
cord-300194-nsp53lv6	58	31	]	]	-RRB-
cord-300194-nsp53lv6	58	32	.	.	.
cord-300194-nsp53lv6	59	1	The	the	DT
cord-300194-nsp53lv6	59	2	NTD	NTD	NNP
cord-300194-nsp53lv6	59	3	is	be	VBZ
cord-300194-nsp53lv6	59	4	the	the	DT
cord-300194-nsp53lv6	59	5	outermost	outermost	JJS
cord-300194-nsp53lv6	59	6	domain	domain	NN
cord-300194-nsp53lv6	59	7	that	that	WDT
cord-300194-nsp53lv6	59	8	is	be	VBZ
cord-300194-nsp53lv6	59	9	relatively	relatively	RB
cord-300194-nsp53lv6	59	10	more	more	RBR
cord-300194-nsp53lv6	59	11	exposed	expose	VBN
cord-300194-nsp53lv6	59	12	and	and	CC
cord-300194-nsp53lv6	59	13	lies	lie	NNS
cord-300194-nsp53lv6	59	14	on	on	IN
cord-300194-nsp53lv6	59	15	the	the	DT
cord-300194-nsp53lv6	59	16	three	three	CD
cord-300194-nsp53lv6	59	17	sides	side	NNS
cord-300194-nsp53lv6	59	18	giving	give	VBG
cord-300194-nsp53lv6	59	19	a	a	DT
cord-300194-nsp53lv6	59	20	triangular	triangular	JJ
cord-300194-nsp53lv6	59	21	shape	shape	NN
cord-300194-nsp53lv6	59	22	to	to	IN
cord-300194-nsp53lv6	59	23	the	the	DT
cord-300194-nsp53lv6	59	24	protein	protein	NN
cord-300194-nsp53lv6	59	25	when	when	WRB
cord-300194-nsp53lv6	59	26	viewed	view	VBN
cord-300194-nsp53lv6	59	27	from	from	IN
cord-300194-nsp53lv6	59	28	top	top	NN
cord-300194-nsp53lv6	60	1	(	(	-LRB-
cord-300194-nsp53lv6	60	2	Figure	figure	NN
cord-300194-nsp53lv6	60	3	1	1	CD
cord-300194-nsp53lv6	60	4	)	)	-RRB-
cord-300194-nsp53lv6	60	5	.	.	.
cord-300194-nsp53lv6	61	1	The	the	DT
cord-300194-nsp53lv6	61	2	NTD	NTD	NNP
cord-300194-nsp53lv6	61	3	has	have	VBZ
cord-300194-nsp53lv6	61	4	a	a	DT
cord-300194-nsp53lv6	61	5	galectin	galectin	XX
cord-300194-nsp53lv6	61	6	fold	fold	VB
cord-300194-nsp53lv6	61	7	and	and	CC
cord-300194-nsp53lv6	61	8	is	be	VBZ
cord-300194-nsp53lv6	61	9	known	know	VBN
cord-300194-nsp53lv6	61	10	to	to	TO
cord-300194-nsp53lv6	61	11	bind	bind	VB
cord-300194-nsp53lv6	61	12	to	to	IN
cord-300194-nsp53lv6	61	13	the	the	DT
cord-300194-nsp53lv6	61	14	sugar	sugar	NN
cord-300194-nsp53lv6	61	15	moieties	moiety	NNS
cord-300194-nsp53lv6	61	16	[	[	-LRB-
cord-300194-nsp53lv6	61	17	21	21	CD
cord-300194-nsp53lv6	61	18	]	]	-RRB-
cord-300194-nsp53lv6	61	19	.	.	.
cord-300194-nsp53lv6	62	1	The	the	DT
cord-300194-nsp53lv6	62	2	S2	S2	NNP
cord-300194-nsp53lv6	62	3	domain	domain	NN
cord-300194-nsp53lv6	62	4	on	on	IN
cord-300194-nsp53lv6	62	5	the	the	DT
cord-300194-nsp53lv6	62	6	other	other	JJ
cord-300194-nsp53lv6	62	7	hand	hand	NN
cord-300194-nsp53lv6	62	8	is	be	VBZ
cord-300194-nsp53lv6	62	9	a	a	DT
cord-300194-nsp53lv6	62	10	transmem	transmem	NNP
cord-300194-nsp53lv6	62	11	rane	rane	NNP
cord-300194-nsp53lv6	62	12	region	region	NN
cord-300194-nsp53lv6	62	13	with	with	IN
cord-300194-nsp53lv6	62	14	strong	strong	JJ
cord-300194-nsp53lv6	62	15	inter	inter	NNP
cord-300194-nsp53lv6	62	16	hain	hain	NNP
cord-300194-nsp53lv6	62	17	onding	onding	NNP
cord-300194-nsp53lv6	62	18	etween	etween	NNP
cord-300194-nsp53lv6	63	1	the	the	DT
cord-300194-nsp53lv6	63	2	residues	residue	NNS
cord-300194-nsp53lv6	63	3	t	t	NN
cord-300194-nsp53lv6	63	4	is	be	VBZ
cord-300194-nsp53lv6	63	5	mostly	mostly	RB
cord-300194-nsp53lv6	63	6	αhelical	αhelical	JJ
cord-300194-nsp53lv6	63	7	and	and	CC
cord-300194-nsp53lv6	63	8	forms	form	VBZ
cord-300194-nsp53lv6	63	9	a	a	DT
cord-300194-nsp53lv6	63	10	triangle	triangle	NN
cord-300194-nsp53lv6	63	11	when	when	WRB
cord-300194-nsp53lv6	63	12	viewed	view	VBN
cord-300194-nsp53lv6	63	13	from	from	IN
cord-300194-nsp53lv6	63	14	bottom	bottom	NN
cord-300194-nsp53lv6	63	15	,	,	,
cord-300194-nsp53lv6	63	16	though	though	IN
cord-300194-nsp53lv6	63	17	there	there	EX
cord-300194-nsp53lv6	63	18	is	be	VBZ
cord-300194-nsp53lv6	63	19	no	no	DT
cord-300194-nsp53lv6	63	20	overlapping	overlapping	NN
cord-300194-nsp53lv6	63	21	of	of	IN
cord-300194-nsp53lv6	63	22	the	the	DT
cord-300194-nsp53lv6	63	23	top	top	JJ
cord-300194-nsp53lv6	63	24	and	and	CC
cord-300194-nsp53lv6	63	25	bottom	bottom	JJ
cord-300194-nsp53lv6	63	26	triangles	triangle	NNS
cord-300194-nsp53lv6	63	27	.	.	.
cord-300194-nsp53lv6	64	1	Temperature	temperature	NN
cord-300194-nsp53lv6	64	2	is	be	VBZ
cord-300194-nsp53lv6	64	3	a	a	DT
cord-300194-nsp53lv6	64	4	very	very	RB
cord-300194-nsp53lv6	64	5	significant	significant	JJ
cord-300194-nsp53lv6	64	6	variable	variable	JJ
cord-300194-nsp53lv6	64	7	parameter	parameter	NN
cord-300194-nsp53lv6	64	8	for	for	IN
cord-300194-nsp53lv6	64	9	proteins	protein	NNS
cord-300194-nsp53lv6	64	10	because	because	IN
cord-300194-nsp53lv6	64	11	proteins	protein	NNS
cord-300194-nsp53lv6	64	12	respond	respond	VBP
cord-300194-nsp53lv6	64	13	differently	differently	RB
cord-300194-nsp53lv6	64	14	in	in	IN
cord-300194-nsp53lv6	64	15	high	high	JJ
cord-300194-nsp53lv6	64	16	and	and	CC
cord-300194-nsp53lv6	64	17	low	low	JJ
cord-300194-nsp53lv6	64	18	temperature	temperature	NN
cord-300194-nsp53lv6	64	19	conditions	condition	NNS
cord-300194-nsp53lv6	64	20	.	.	.
cord-300194-nsp53lv6	65	1	Many	many	JJ
cord-300194-nsp53lv6	65	2	proteins	protein	NNS
cord-300194-nsp53lv6	65	3	have	have	VBP
cord-300194-nsp53lv6	65	4	high	high	JJ
cord-300194-nsp53lv6	65	5	thermal	thermal	JJ
cord-300194-nsp53lv6	65	6	stability	stability	NN
cord-300194-nsp53lv6	65	7	while	while	IN
cord-300194-nsp53lv6	65	8	others	other	NNS
cord-300194-nsp53lv6	65	9	can	can	MD
cord-300194-nsp53lv6	65	10	unfold	unfold	VB
cord-300194-nsp53lv6	65	11	or	or	CC
cord-300194-nsp53lv6	65	12	even	even	RB
cord-300194-nsp53lv6	65	13	denature	denature	VB
cord-300194-nsp53lv6	65	14	at	at	IN
cord-300194-nsp53lv6	65	15	high	high	JJ
cord-300194-nsp53lv6	65	16	temperatures	temperature	NNS
cord-300194-nsp53lv6	65	17	[	[	-LRB-
cord-300194-nsp53lv6	65	18	23	23	CD
cord-300194-nsp53lv6	65	19	,	,	,
cord-300194-nsp53lv6	65	20	24	24	CD
cord-300194-nsp53lv6	65	21	]	]	-RRB-
cord-300194-nsp53lv6	65	22	.	.	.
cord-300194-nsp53lv6	66	1	During	during	IN
cord-300194-nsp53lv6	66	2	November	November	NNP
cord-300194-nsp53lv6	66	3	,	,	,
cord-300194-nsp53lv6	66	4	2019	2019	CD
cord-300194-nsp53lv6	66	5	,	,	,
cord-300194-nsp53lv6	66	6	when	when	WRB
cord-300194-nsp53lv6	66	7	the	the	DT
cord-300194-nsp53lv6	66	8	first	first	JJ
cord-300194-nsp53lv6	66	9	out	out	IN
cord-300194-nsp53lv6	66	10	reak	reak	NN
cord-300194-nsp53lv6	66	11	of	of	IN
cord-300194-nsp53lv6	66	12	ovid1	ovid1	NN
cord-300194-nsp53lv6	66	13	was	be	VBD
cord-300194-nsp53lv6	66	14	reported	report	VBN
cord-300194-nsp53lv6	66	15	the	the	DT
cord-300194-nsp53lv6	66	16	temperature	temperature	NN
cord-300194-nsp53lv6	66	17	in	in	IN
cord-300194-nsp53lv6	66	18	uhan	uhan	NNP
cord-300194-nsp53lv6	66	19	hina	hina	NNP
cord-300194-nsp53lv6	66	20	was	be	VBD
cord-300194-nsp53lv6	66	21	around	around	RB
cord-300194-nsp53lv6	66	22	1	1	CD
cord-300194-nsp53lv6	66	23	in	in	IN
cord-300194-nsp53lv6	66	24	the	the	DT
cord-300194-nsp53lv6	66	25	morning	morning	NN
cord-300194-nsp53lv6	66	26	and	and	CC
cord-300194-nsp53lv6	66	27	at	at	IN
cord-300194-nsp53lv6	66	28	night	night	NN
cord-300194-nsp53lv6	66	29	Tropi	Tropi	NNP
cord-300194-nsp53lv6	66	30	al	al	NNP
cord-300194-nsp53lv6	66	31	ountries	ountrie	NNS
cord-300194-nsp53lv6	66	32	such	such	JJ
cord-300194-nsp53lv6	66	33	as	as	IN
cord-300194-nsp53lv6	66	34	India	India	NNP
cord-300194-nsp53lv6	66	35	,	,	,
cord-300194-nsp53lv6	66	36	where	where	WRB
cord-300194-nsp53lv6	66	37	a	a	DT
cord-300194-nsp53lv6	66	38	large	large	JJ
cord-300194-nsp53lv6	66	39	number	number	NN
cord-300194-nsp53lv6	66	40	of	of	IN
cord-300194-nsp53lv6	66	41	cases	case	NNS
cord-300194-nsp53lv6	66	42	still	still	RB
cord-300194-nsp53lv6	66	43	persist	persist	VBP
cord-300194-nsp53lv6	66	44	,	,	,
cord-300194-nsp53lv6	66	45	had	have	VBD
cord-300194-nsp53lv6	66	46	over	over	IN
cord-300194-nsp53lv6	66	47	of	of	IN
cord-300194-nsp53lv6	66	48	temperature	temperature	NN
cord-300194-nsp53lv6	66	49	[	[	-LRB-
cord-300194-nsp53lv6	66	50	25	25	CD
cord-300194-nsp53lv6	66	51	,	,	,
cord-300194-nsp53lv6	66	52	26	26	CD
cord-300194-nsp53lv6	66	53	]	]	-RRB-
cord-300194-nsp53lv6	66	54	.	.	.
cord-300194-nsp53lv6	67	1	Although	although	IN
cord-300194-nsp53lv6	67	2	statistical	statistical	JJ
cord-300194-nsp53lv6	67	3	and	and	CC
cord-300194-nsp53lv6	67	4	experimental	experimental	JJ
cord-300194-nsp53lv6	67	5	evidence	evidence	NN
cord-300194-nsp53lv6	67	6	show	show	VBP
cord-300194-nsp53lv6	67	7	that	that	IN
cord-300194-nsp53lv6	67	8	temperature	temperature	NN
cord-300194-nsp53lv6	67	9	influences	influence	VBZ
cord-300194-nsp53lv6	67	10	the	the	DT
cord-300194-nsp53lv6	67	11	activity	activity	NN
cord-300194-nsp53lv6	67	12	and	and	CC
cord-300194-nsp53lv6	67	13	virulence	virulence	NN
cord-300194-nsp53lv6	67	14	of	of	IN
cord-300194-nsp53lv6	67	15	the	the	DT
cord-300194-nsp53lv6	67	16	virus	virus	NN
cord-300194-nsp53lv6	67	17	,	,	,
cord-300194-nsp53lv6	67	18	we	-PRON-	PRP
cord-300194-nsp53lv6	67	19	still	still	RB
cord-300194-nsp53lv6	67	20	lack	lack	VBP
cord-300194-nsp53lv6	67	21	7	7	CD
cord-300194-nsp53lv6	67	22	the	the	DT
cord-300194-nsp53lv6	67	23	understanding	understanding	NN
cord-300194-nsp53lv6	67	24	of	of	IN
cord-300194-nsp53lv6	67	25	the	the	DT
cord-300194-nsp53lv6	67	26	molecular	molecular	JJ
cord-300194-nsp53lv6	67	27	level	level	NN
cord-300194-nsp53lv6	67	28	changes	change	NNS
cord-300194-nsp53lv6	67	29	that	that	WDT
cord-300194-nsp53lv6	67	30	are	be	VBP
cord-300194-nsp53lv6	67	31	taking	take	VBG
cord-300194-nsp53lv6	67	32	place	place	NN
cord-300194-nsp53lv6	67	33	in	in	IN
cord-300194-nsp53lv6	67	34	the	the	DT
cord-300194-nsp53lv6	67	35	virus	virus	NN
cord-300194-nsp53lv6	67	36	due	due	IN
cord-300194-nsp53lv6	67	37	to	to	IN
cord-300194-nsp53lv6	67	38	the	the	DT
cord-300194-nsp53lv6	67	39	different	different	JJ
cord-300194-nsp53lv6	67	40	weather	weather	NN
cord-300194-nsp53lv6	67	41	conditions	condition	NNS
cord-300194-nsp53lv6	67	42	.	.	.
cord-300194-nsp53lv6	68	1	Till	till	IN
cord-300194-nsp53lv6	68	2	date	date	NN
cord-300194-nsp53lv6	68	3	,	,	,
cord-300194-nsp53lv6	68	4	there	there	EX
cord-300194-nsp53lv6	68	5	is	be	VBZ
cord-300194-nsp53lv6	68	6	no	no	DT
cord-300194-nsp53lv6	68	7	concrete	concrete	JJ
cord-300194-nsp53lv6	68	8	evidence	evidence	NN
cord-300194-nsp53lv6	68	9	on	on	IN
cord-300194-nsp53lv6	68	10	whether	whether	IN
cord-300194-nsp53lv6	68	11	atmospheric	atmospheric	JJ
cord-300194-nsp53lv6	68	12	conditions	condition	NNS
cord-300194-nsp53lv6	68	13	actually	actually	RB
cord-300194-nsp53lv6	68	14	influence	influence	VBP
cord-300194-nsp53lv6	68	15	the	the	DT
cord-300194-nsp53lv6	68	16	structure	structure	NN
cord-300194-nsp53lv6	68	17	of	of	IN
cord-300194-nsp53lv6	68	18	the	the	DT
cord-300194-nsp53lv6	68	19	virus	virus	NN
cord-300194-nsp53lv6	68	20	.	.	.
cord-300194-nsp53lv6	69	1	Here	here	RB
cord-300194-nsp53lv6	69	2	,	,	,
cord-300194-nsp53lv6	69	3	by	by	IN
cord-300194-nsp53lv6	69	4	using	use	VBG
cord-300194-nsp53lv6	69	5	all	all	DT
cord-300194-nsp53lv6	69	6	atom	atom	NN
cord-300194-nsp53lv6	69	7	molecular	molecular	JJ
cord-300194-nsp53lv6	69	8	dynamics	dynamic	NNS
cord-300194-nsp53lv6	69	9	(	(	-LRB-
cord-300194-nsp53lv6	69	10	MD	MD	NNP
cord-300194-nsp53lv6	69	11	)	)	-RRB-
cord-300194-nsp53lv6	69	12	simulations	simulation	NNS
cord-300194-nsp53lv6	69	13	we	-PRON-	PRP
cord-300194-nsp53lv6	69	14	explore	explore	VBP
cord-300194-nsp53lv6	69	15	the	the	DT
cord-300194-nsp53lv6	69	16	dynamics	dynamic	NNS
cord-300194-nsp53lv6	69	17	of	of	IN
cord-300194-nsp53lv6	69	18	the	the	DT
cord-300194-nsp53lv6	69	19	Spike	Spike	NNP
cord-300194-nsp53lv6	69	20	glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	69	21	of	of	IN
cord-300194-nsp53lv6	69	22	SARS	SARS	NNP
cord-300194-nsp53lv6	69	23	-	-	HYPH
cord-300194-nsp53lv6	69	24	COV-2	COV-2	NNP
cord-300194-nsp53lv6	69	25	at	at	IN
cord-300194-nsp53lv6	69	26	different	different	JJ
cord-300194-nsp53lv6	69	27	temperatures	temperature	NNS
cord-300194-nsp53lv6	69	28	.	.	.
cord-300194-nsp53lv6	70	1	This	this	DT
cord-300194-nsp53lv6	70	2	is	be	VBZ
cord-300194-nsp53lv6	70	3	the	the	DT
cord-300194-nsp53lv6	70	4	first	first	JJ
cord-300194-nsp53lv6	70	5	molecular	molecular	JJ
cord-300194-nsp53lv6	70	6	study	study	NN
cord-300194-nsp53lv6	70	7	on	on	IN
cord-300194-nsp53lv6	70	8	the	the	DT
cord-300194-nsp53lv6	70	9	environmental	environmental	JJ
cord-300194-nsp53lv6	70	10	influence	influence	NN
cord-300194-nsp53lv6	70	11	on	on	IN
cord-300194-nsp53lv6	70	12	the	the	DT
cord-300194-nsp53lv6	70	13	protein	protein	NN
cord-300194-nsp53lv6	70	14	structure	structure	NN
cord-300194-nsp53lv6	70	15	.	.	.
cord-300194-nsp53lv6	71	1	Results	result	NNS
cord-300194-nsp53lv6	71	2	suggest	suggest	VBP
cord-300194-nsp53lv6	71	3	that	that	IN
cord-300194-nsp53lv6	71	4	S1	s1	NN
cord-300194-nsp53lv6	71	5	domain	domain	NN
cord-300194-nsp53lv6	71	6	is	be	VBZ
cord-300194-nsp53lv6	71	7	more	more	RBR
cord-300194-nsp53lv6	71	8	flexible	flexible	JJ
cord-300194-nsp53lv6	71	9	than	than	IN
cord-300194-nsp53lv6	71	10	S2	S2	NNP
cord-300194-nsp53lv6	71	11	.	.	.
cord-300194-nsp53lv6	72	1	In	in	IN
cord-300194-nsp53lv6	72	2	the	the	DT
cord-300194-nsp53lv6	72	3	S1	S1	NNP
cord-300194-nsp53lv6	72	4	domain	domain	NN
cord-300194-nsp53lv6	72	5	,	,	,
cord-300194-nsp53lv6	72	6	we	-PRON-	PRP
cord-300194-nsp53lv6	72	7	observed	observe	VBD
cord-300194-nsp53lv6	72	8	the	the	DT
cord-300194-nsp53lv6	72	9	sensitivity	sensitivity	NN
cord-300194-nsp53lv6	72	10	of	of	IN
cord-300194-nsp53lv6	72	11	the	the	DT
cord-300194-nsp53lv6	72	12	receptor	receptor	NN
cord-300194-nsp53lv6	72	13	binding	bind	VBG
cord-300194-nsp53lv6	72	14	motif	motif	NN
cord-300194-nsp53lv6	72	15	to	to	IN
cord-300194-nsp53lv6	72	16	different	different	JJ
cord-300194-nsp53lv6	72	17	temperatures	temperature	NNS
cord-300194-nsp53lv6	72	18	.	.	.
cord-300194-nsp53lv6	73	1	We	-PRON-	PRP
cord-300194-nsp53lv6	73	2	also	also	RB
cord-300194-nsp53lv6	73	3	found	find	VBD
cord-300194-nsp53lv6	73	4	that	that	IN
cord-300194-nsp53lv6	73	5	the	the	DT
cord-300194-nsp53lv6	73	6	N	n	CD
cord-300194-nsp53lv6	73	7	-	-	HYPH
cord-300194-nsp53lv6	73	8	terminal	terminal	NN
cord-300194-nsp53lv6	73	9	domain	domain	NN
cord-300194-nsp53lv6	73	10	of	of	IN
cord-300194-nsp53lv6	73	11	the	the	DT
cord-300194-nsp53lv6	73	12	protein	protein	NN
cord-300194-nsp53lv6	73	13	has	have	VBZ
cord-300194-nsp53lv6	73	14	the	the	DT
cord-300194-nsp53lv6	73	15	potential	potential	NN
cord-300194-nsp53lv6	73	16	of	of	IN
cord-300194-nsp53lv6	73	17	binding	bind	VBG
cord-300194-nsp53lv6	73	18	to	to	IN
cord-300194-nsp53lv6	73	19	different	different	JJ
cord-300194-nsp53lv6	73	20	human	human	JJ
cord-300194-nsp53lv6	73	21	receptors	receptor	NNS
cord-300194-nsp53lv6	73	22	.	.	.
cord-300194-nsp53lv6	74	1	The	the	DT
cord-300194-nsp53lv6	74	2	study	study	NN
cord-300194-nsp53lv6	74	3	will	will	MD
cord-300194-nsp53lv6	74	4	not	not	RB
cord-300194-nsp53lv6	74	5	only	only	RB
cord-300194-nsp53lv6	74	6	help	help	VB
cord-300194-nsp53lv6	74	7	us	-PRON-	PRP
cord-300194-nsp53lv6	74	8	in	in	IN
cord-300194-nsp53lv6	74	9	understanding	understand	VBG
cord-300194-nsp53lv6	74	10	the	the	DT
cord-300194-nsp53lv6	74	11	nature	nature	NN
cord-300194-nsp53lv6	74	12	of	of	IN
cord-300194-nsp53lv6	74	13	the	the	DT
cord-300194-nsp53lv6	74	14	virus	virus	NN
cord-300194-nsp53lv6	74	15	but	but	CC
cord-300194-nsp53lv6	74	16	is	be	VBZ
cord-300194-nsp53lv6	74	17	also	also	RB
cord-300194-nsp53lv6	74	18	useful	useful	JJ
cord-300194-nsp53lv6	74	19	to	to	TO
cord-300194-nsp53lv6	74	20	design	design	VB
cord-300194-nsp53lv6	74	21	effective	effective	JJ
cord-300194-nsp53lv6	74	22	therapeutic	therapeutic	JJ
cord-300194-nsp53lv6	74	23	strategies	strategy	NNS
cord-300194-nsp53lv6	74	24	.	.	.
cord-300194-nsp53lv6	75	1	The	the	DT
cord-300194-nsp53lv6	75	2	crystal	crystal	JJ
cord-300194-nsp53lv6	75	3	structure	structure	NN
cord-300194-nsp53lv6	75	4	of	of	IN
cord-300194-nsp53lv6	75	5	the	the	DT
cord-300194-nsp53lv6	75	6	Spike	Spike	NNP
cord-300194-nsp53lv6	75	7	glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	75	8	(	(	-LRB-
cord-300194-nsp53lv6	75	9	PDB	PDB	NNP
cord-300194-nsp53lv6	75	10	:	:	:
cord-300194-nsp53lv6	75	11	6VXX	6vxx	LS
cord-300194-nsp53lv6	75	12	)	)	-RRB-
cord-300194-nsp53lv6	75	13	was	be	VBD
cord-300194-nsp53lv6	75	14	found	find	VBN
cord-300194-nsp53lv6	75	15	to	to	TO
cord-300194-nsp53lv6	75	16	have	have	VB
cord-300194-nsp53lv6	75	17	871	871	CD
cord-300194-nsp53lv6	75	18	missing	miss	VBG
cord-300194-nsp53lv6	75	19	residues	residue	NNS
cord-300194-nsp53lv6	75	20	.	.	.
cord-300194-nsp53lv6	76	1	Thus	thus	RB
cord-300194-nsp53lv6	76	2	,	,	,
cord-300194-nsp53lv6	76	3	for	for	IN
cord-300194-nsp53lv6	76	4	our	-PRON-	PRP$
cord-300194-nsp53lv6	76	5	study	study	NN
cord-300194-nsp53lv6	76	6	we	-PRON-	PRP
cord-300194-nsp53lv6	76	7	considered	consider	VBD
cord-300194-nsp53lv6	76	8	the	the	DT
cord-300194-nsp53lv6	76	9	complete	complete	JJ
cord-300194-nsp53lv6	76	10	model	model	NN
cord-300194-nsp53lv6	76	11	of	of	IN
cord-300194-nsp53lv6	76	12	the	the	DT
cord-300194-nsp53lv6	76	13	trimeric	trimeric	NNP
cord-300194-nsp53lv6	76	14	Spike	Spike	NNP
cord-300194-nsp53lv6	76	15	protein	protein	NN
cord-300194-nsp53lv6	76	16	generated	generate	VBN
cord-300194-nsp53lv6	76	17	by	by	IN
cord-300194-nsp53lv6	76	18	Zhang	Zhang	NNP
cord-300194-nsp53lv6	76	19	et	et	NNP
cord-300194-nsp53lv6	76	20	.	.	.
cord-300194-nsp53lv6	77	1	al	al	NNP
cord-300194-nsp53lv6	77	2	.	.	.
cord-300194-nsp53lv6	78	1	and	and	CC
cord-300194-nsp53lv6	78	2	had	have	VBD
cord-300194-nsp53lv6	78	3	a	a	DT
cord-300194-nsp53lv6	78	4	Template	template	NN
cord-300194-nsp53lv6	78	5	modeling	modeling	NN
cord-300194-nsp53lv6	78	6	score	score	NN
cord-300194-nsp53lv6	78	7	of	of	IN
cord-300194-nsp53lv6	78	8	0.6	0.6	CD
cord-300194-nsp53lv6	78	9	[	[	-LRB-
cord-300194-nsp53lv6	78	10	27	27	CD
cord-300194-nsp53lv6	78	11	]	]	-RRB-
cord-300194-nsp53lv6	78	12	.	.	.
cord-300194-nsp53lv6	79	1	The	the	DT
cord-300194-nsp53lv6	79	2	model	model	NN
cord-300194-nsp53lv6	79	3	was	be	VBD
cord-300194-nsp53lv6	79	4	devoid	devoid	JJ
cord-300194-nsp53lv6	79	5	of	of	IN
cord-300194-nsp53lv6	79	6	N	n	NN
cord-300194-nsp53lv6	79	7	-	-	HYPH
cord-300194-nsp53lv6	79	8	acetyl	acetyl	NN
cord-300194-nsp53lv6	79	9	glucosamine	glucosamine	NN
cord-300194-nsp53lv6	79	10	(	(	-LRB-
cord-300194-nsp53lv6	79	11	NAG	NAG	NNP
cord-300194-nsp53lv6	79	12	)	)	-RRB-
cord-300194-nsp53lv6	79	13	sugar	sugar	NN
cord-300194-nsp53lv6	79	14	moieties	moiety	NNS
cord-300194-nsp53lv6	79	15	which	which	WDT
cord-300194-nsp53lv6	79	16	are	be	VBP
cord-300194-nsp53lv6	79	17	known	know	VBN
cord-300194-nsp53lv6	79	18	to	to	TO
cord-300194-nsp53lv6	79	19	bind	bind	VB
cord-300194-nsp53lv6	79	20	and	and	CC
cord-300194-nsp53lv6	79	21	stabilize	stabilize	VB
cord-300194-nsp53lv6	79	22	the	the	DT
cord-300194-nsp53lv6	79	23	protein	protein	NN
cord-300194-nsp53lv6	79	24	.	.	.
cord-300194-nsp53lv6	80	1	The	the	DT
cord-300194-nsp53lv6	80	2	envelope	envelope	NN
cord-300194-nsp53lv6	80	3	lipid	lipid	NN
cord-300194-nsp53lv6	80	4	bilayer	bilayer	NN
cord-300194-nsp53lv6	80	5	was	be	VBD
cord-300194-nsp53lv6	80	6	not	not	RB
cord-300194-nsp53lv6	80	7	considered	consider	VBN
cord-300194-nsp53lv6	80	8	in	in	IN
cord-300194-nsp53lv6	80	9	the	the	DT
cord-300194-nsp53lv6	80	10	work	work	NN
cord-300194-nsp53lv6	80	11	to	to	TO
cord-300194-nsp53lv6	80	12	avoid	avoid	VB
cord-300194-nsp53lv6	80	13	large	large	JJ
cord-300194-nsp53lv6	80	14	system	system	NN
cord-300194-nsp53lv6	80	15	size	size	NN
cord-300194-nsp53lv6	80	16	in	in	IN
cord-300194-nsp53lv6	80	17	atomistic	atomistic	JJ
cord-300194-nsp53lv6	80	18	simulations	simulation	NNS
cord-300194-nsp53lv6	80	19	.	.	.
cord-300194-nsp53lv6	81	1	fter	fter	JJ
cord-300194-nsp53lv6	81	2	initial	initial	JJ
cord-300194-nsp53lv6	81	3	minimization	minimization	NN
cord-300194-nsp53lv6	81	4	and	and	CC
cord-300194-nsp53lv6	81	5	equili	equili	NNP
cord-300194-nsp53lv6	81	6	ration	ration	NN
cord-300194-nsp53lv6	82	1	we	-PRON-	PRP
cord-300194-nsp53lv6	82	2	generated	generate	VBD
cord-300194-nsp53lv6	82	3	five	five	CD
cord-300194-nsp53lv6	82	4	different	different	JJ
cord-300194-nsp53lv6	82	5	systems	system	NNS
cord-300194-nsp53lv6	82	6	having	have	VBG
cord-300194-nsp53lv6	82	7	temperatures	temperature	NNS
cord-300194-nsp53lv6	82	8	ranging	range	VBG
cord-300194-nsp53lv6	82	9	from	from	IN
cord-300194-nsp53lv6	82	10	1	1	CD
cord-300194-nsp53lv6	82	11	to	to	IN
cord-300194-nsp53lv6	82	12	at	at	IN
cord-300194-nsp53lv6	82	13	an	an	DT
cord-300194-nsp53lv6	82	14	interval	interval	NN
cord-300194-nsp53lv6	82	15	of	of	IN
cord-300194-nsp53lv6	82	16	10	10	CD
cord-300194-nsp53lv6	82	17	degrees	degree	NNS
cord-300194-nsp53lv6	82	18	.	.	.
cord-300194-nsp53lv6	83	1	This	this	DT
cord-300194-nsp53lv6	83	2	was	be	VBD
cord-300194-nsp53lv6	83	3	done	do	VBN
cord-300194-nsp53lv6	83	4	to	to	TO
cord-300194-nsp53lv6	83	5	maintain	maintain	VB
cord-300194-nsp53lv6	83	6	the	the	DT
cord-300194-nsp53lv6	83	7	uniformity	uniformity	NN
cord-300194-nsp53lv6	83	8	of	of	IN
cord-300194-nsp53lv6	83	9	the	the	DT
cord-300194-nsp53lv6	83	10	simulations	simulation	NNS
cord-300194-nsp53lv6	83	11	,	,	,
cord-300194-nsp53lv6	83	12	where	where	WRB
cord-300194-nsp53lv6	83	13	temperature	temperature	NN
cord-300194-nsp53lv6	83	14	was	be	VBD
cord-300194-nsp53lv6	83	15	the	the	DT
cord-300194-nsp53lv6	83	16	only	only	JJ
cord-300194-nsp53lv6	83	17	variable	variable	NN
cord-300194-nsp53lv6	83	18	that	that	WDT
cord-300194-nsp53lv6	83	19	was	be	VBD
cord-300194-nsp53lv6	83	20	different	different	JJ
cord-300194-nsp53lv6	83	21	.	.	.
cord-300194-nsp53lv6	84	1	n	n	CC
cord-300194-nsp53lv6	84	2	addition	addition	NN
cord-300194-nsp53lv6	84	3	a	a	DT
cord-300194-nsp53lv6	84	4	temperature	temperature	NN
cord-300194-nsp53lv6	84	5	of	of	IN
cord-300194-nsp53lv6	84	6	was	be	VBD
cord-300194-nsp53lv6	84	7	also	also	RB
cord-300194-nsp53lv6	84	8	imposed	impose	VBN
cord-300194-nsp53lv6	84	9	on	on	IN
cord-300194-nsp53lv6	84	10	the	the	DT
cord-300194-nsp53lv6	84	11	system	system	NN
cord-300194-nsp53lv6	84	12	to	to	TO
cord-300194-nsp53lv6	84	13	observe	observe	VB
cord-300194-nsp53lv6	84	14	any	any	DT
cord-300194-nsp53lv6	84	15	8	8	CD
cord-300194-nsp53lv6	84	16	possible	possible	JJ
cord-300194-nsp53lv6	84	17	deformation	deformation	NN
cord-300194-nsp53lv6	84	18	in	in	IN
cord-300194-nsp53lv6	84	19	the	the	DT
cord-300194-nsp53lv6	84	20	structure	structure	NN
cord-300194-nsp53lv6	84	21	of	of	IN
cord-300194-nsp53lv6	84	22	spike	spike	NN
cord-300194-nsp53lv6	84	23	protein	protein	NN
cord-300194-nsp53lv6	84	24	,	,	,
cord-300194-nsp53lv6	84	25	although	although	IN
cord-300194-nsp53lv6	84	26	this	this	DT
cord-300194-nsp53lv6	84	27	high	high	JJ
cord-300194-nsp53lv6	84	28	temperature	temperature	NN
cord-300194-nsp53lv6	84	29	is	be	VBZ
cord-300194-nsp53lv6	84	30	not	not	RB
cord-300194-nsp53lv6	84	31	realistic	realistic	JJ
cord-300194-nsp53lv6	84	32	to	to	TO
cord-300194-nsp53lv6	84	33	imitate	imitate	VB
cord-300194-nsp53lv6	84	34	the	the	DT
cord-300194-nsp53lv6	84	35	environmental	environmental	JJ
cord-300194-nsp53lv6	84	36	condition	condition	NN
cord-300194-nsp53lv6	84	37	(	(	-LRB-
cord-300194-nsp53lv6	84	38	Table	Table	NNP
cord-300194-nsp53lv6	84	39	S1	S1	NNP
cord-300194-nsp53lv6	84	40	)	)	-RRB-
cord-300194-nsp53lv6	84	41	.	.	.
cord-300194-nsp53lv6	85	1	Production	production	NN
cord-300194-nsp53lv6	85	2	run	run	NN
cord-300194-nsp53lv6	85	3	for	for	IN
cord-300194-nsp53lv6	85	4	200ns	200ns	NNP
cord-300194-nsp53lv6	85	5	was	be	VBD
cord-300194-nsp53lv6	85	6	carried	carry	VBN
cord-300194-nsp53lv6	85	7	out	out	RP
cord-300194-nsp53lv6	85	8	in	in	IN
cord-300194-nsp53lv6	85	9	isothermal	isothermal	JJ
cord-300194-nsp53lv6	85	10	isobaric	isobaric	JJ
cord-300194-nsp53lv6	85	11	(	(	-LRB-
cord-300194-nsp53lv6	85	12	NPT	NPT	NNP
cord-300194-nsp53lv6	85	13	)	)	-RRB-
cord-300194-nsp53lv6	85	14	ensemble	ensemble	NN
cord-300194-nsp53lv6	85	15	.	.	.
cord-300194-nsp53lv6	86	1	After	after	IN
cord-300194-nsp53lv6	86	2	performing	perform	VBG
cord-300194-nsp53lv6	86	3	200ns	200ns	NN
cord-300194-nsp53lv6	86	4	of	of	IN
cord-300194-nsp53lv6	86	5	classical	classical	JJ
cord-300194-nsp53lv6	86	6	Molecular	Molecular	NNP
cord-300194-nsp53lv6	86	7	dynamics	dynamic	NNS
cord-300194-nsp53lv6	86	8	simulations	simulation	NNS
cord-300194-nsp53lv6	86	9	,	,	,
cord-300194-nsp53lv6	86	10	the	the	DT
cord-300194-nsp53lv6	86	11	root	root	NN
cord-300194-nsp53lv6	86	12	mean	mean	VBP
cord-300194-nsp53lv6	86	13	square	square	JJ
cord-300194-nsp53lv6	86	14	deviation	deviation	NN
cord-300194-nsp53lv6	86	15	(	(	-LRB-
cord-300194-nsp53lv6	86	16	RMSD	RMSD	NNP
cord-300194-nsp53lv6	86	17	)	)	-RRB-
cord-300194-nsp53lv6	86	18	of	of	IN
cord-300194-nsp53lv6	86	19	the	the	DT
cord-300194-nsp53lv6	86	20	trajectory	trajectory	NN
cord-300194-nsp53lv6	86	21	,	,	,
cord-300194-nsp53lv6	86	22	with	with	IN
cord-300194-nsp53lv6	86	23	respect	respect	NN
cord-300194-nsp53lv6	86	24	to	to	IN
cord-300194-nsp53lv6	86	25	the	the	DT
cord-300194-nsp53lv6	86	26	starting	starting	NN
cord-300194-nsp53lv6	86	27	structure	structure	NN
cord-300194-nsp53lv6	86	28	,	,	,
cord-300194-nsp53lv6	86	29	was	be	VBD
cord-300194-nsp53lv6	86	30	calculated	calculate	VBN
cord-300194-nsp53lv6	86	31	to	to	TO
cord-300194-nsp53lv6	86	32	check	check	VB
cord-300194-nsp53lv6	86	33	if	if	IN
cord-300194-nsp53lv6	86	34	the	the	DT
cord-300194-nsp53lv6	86	35	systems	system	NNS
cord-300194-nsp53lv6	86	36	have	have	VBP
cord-300194-nsp53lv6	86	37	attained	attain	VBN
cord-300194-nsp53lv6	86	38	stability	stability	NN
cord-300194-nsp53lv6	86	39	.	.	.
cord-300194-nsp53lv6	87	1	Figure	figure	NN
cord-300194-nsp53lv6	87	2	S1	s1	NN
cord-300194-nsp53lv6	87	3	shows	show	VBZ
cord-300194-nsp53lv6	87	4	the	the	DT
cord-300194-nsp53lv6	87	5	complete	complete	JJ
cord-300194-nsp53lv6	87	6	RMSD	rmsd	NN
cord-300194-nsp53lv6	87	7	of	of	IN
cord-300194-nsp53lv6	87	8	all	all	PDT
cord-300194-nsp53lv6	87	9	the	the	DT
cord-300194-nsp53lv6	87	10	systems	system	NNS
cord-300194-nsp53lv6	87	11	at	at	IN
cord-300194-nsp53lv6	87	12	different	different	JJ
cord-300194-nsp53lv6	87	13	temperatures	temperature	NNS
cord-300194-nsp53lv6	87	14	.	.	.
cord-300194-nsp53lv6	88	1	It	-PRON-	PRP
cord-300194-nsp53lv6	88	2	can	can	MD
cord-300194-nsp53lv6	88	3	be	be	VB
cord-300194-nsp53lv6	88	4	seen	see	VBN
cord-300194-nsp53lv6	88	5	that	that	IN
cord-300194-nsp53lv6	88	6	the	the	DT
cord-300194-nsp53lv6	88	7	stability	stability	NN
cord-300194-nsp53lv6	88	8	was	be	VBD
cord-300194-nsp53lv6	88	9	attained	attain	VBN
cord-300194-nsp53lv6	88	10	within	within	IN
cord-300194-nsp53lv6	88	11	the	the	DT
cord-300194-nsp53lv6	88	12	first	first	JJ
cord-300194-nsp53lv6	88	13	ns	ns	NN
cord-300194-nsp53lv6	88	14	of	of	IN
cord-300194-nsp53lv6	88	15	the	the	DT
cord-300194-nsp53lv6	88	16	simulation	simulation	NN
cord-300194-nsp53lv6	88	17	time	time	NN
cord-300194-nsp53lv6	88	18	thus	thus	RB
cord-300194-nsp53lv6	88	19	indi	indi	NNP
cord-300194-nsp53lv6	88	20	ating	ating	NNP
cord-300194-nsp53lv6	89	1	that	that	IN
cord-300194-nsp53lv6	89	2	the	the	DT
cord-300194-nsp53lv6	89	3	systems	system	NNS
cord-300194-nsp53lv6	89	4	are	be	VBP
cord-300194-nsp53lv6	89	5	well	well	JJ
cord-300194-nsp53lv6	90	1	equili	equili	NNP
cord-300194-nsp53lv6	90	2	rated	rate	VBD
cord-300194-nsp53lv6	91	1	The	the	DT
cord-300194-nsp53lv6	91	2	R	r	NN
cord-300194-nsp53lv6	91	3	S	S	NNP
cord-300194-nsp53lv6	91	4	values	value	NNS
cord-300194-nsp53lv6	91	5	lie	lie	VBP
cord-300194-nsp53lv6	91	6	etween	etween	NNP
cord-300194-nsp53lv6	91	7	nm	nm	NN
cord-300194-nsp53lv6	91	8	for	for	IN
cord-300194-nsp53lv6	91	9	all	all	PDT
cord-300194-nsp53lv6	91	10	the	the	DT
cord-300194-nsp53lv6	91	11	systems	system	NNS
cord-300194-nsp53lv6	91	12	with	with	IN
cord-300194-nsp53lv6	91	13	an	an	DT
cord-300194-nsp53lv6	91	14	ex	ex	NN
cord-300194-nsp53lv6	91	15	eption	eption	NN
cord-300194-nsp53lv6	91	16	at	at	IN
cord-300194-nsp53lv6	91	17	where	where	WRB
cord-300194-nsp53lv6	91	18	a	a	DT
cord-300194-nsp53lv6	91	19	marginally	marginally	RB
cord-300194-nsp53lv6	91	20	higher	high	JJR
cord-300194-nsp53lv6	91	21	RMSD	RMSD	NNP
cord-300194-nsp53lv6	91	22	was	be	VBD
cord-300194-nsp53lv6	91	23	seen	see	VBN
cord-300194-nsp53lv6	91	24	after	after	IN
cord-300194-nsp53lv6	91	25	100ns	100ns	CD
cord-300194-nsp53lv6	91	26	of	of	IN
cord-300194-nsp53lv6	91	27	simulation	simulation	NN
cord-300194-nsp53lv6	91	28	time	time	NN
cord-300194-nsp53lv6	91	29	.	.	.
cord-300194-nsp53lv6	92	1	At	at	IN
cord-300194-nsp53lv6	92	2	temperatures	temperature	NNS
cord-300194-nsp53lv6	92	3	and	and	CC
cord-300194-nsp53lv6	92	4	a	a	DT
cord-300194-nsp53lv6	92	5	small	small	JJ
cord-300194-nsp53lv6	92	6	rise	rise	NN
cord-300194-nsp53lv6	92	7	in	in	IN
cord-300194-nsp53lv6	92	8	RMSD	RMSD	NNP
cord-300194-nsp53lv6	92	9	curves	curve	NNS
cord-300194-nsp53lv6	92	10	after	after	IN
cord-300194-nsp53lv6	92	11	100ns	100ns	CD
cord-300194-nsp53lv6	92	12	of	of	IN
cord-300194-nsp53lv6	92	13	simulation	simulation	NN
cord-300194-nsp53lv6	92	14	time	time	NN
cord-300194-nsp53lv6	92	15	was	be	VBD
cord-300194-nsp53lv6	92	16	observed	observe	VBN
cord-300194-nsp53lv6	92	17	.	.	.
cord-300194-nsp53lv6	93	1	This	this	DT
cord-300194-nsp53lv6	93	2	implies	imply	VBZ
cord-300194-nsp53lv6	93	3	that	that	IN
cord-300194-nsp53lv6	93	4	the	the	DT
cord-300194-nsp53lv6	93	5	Spike	Spike	NNP
cord-300194-nsp53lv6	93	6	protein	protein	NN
cord-300194-nsp53lv6	93	7	was	be	VBD
cord-300194-nsp53lv6	93	8	more	more	JJR
cord-300194-nsp53lv6	93	9	sta	sta	NNP
cord-300194-nsp53lv6	93	10	le	le	FW
cord-300194-nsp53lv6	93	11	at	at	IN
cord-300194-nsp53lv6	93	12	temperatures	temperature	NNS
cord-300194-nsp53lv6	93	13	1	1	CD
cord-300194-nsp53lv6	93	14	and	and	CC
cord-300194-nsp53lv6	93	15	Since	since	IN
cord-300194-nsp53lv6	93	16	,	,	,
cord-300194-nsp53lv6	93	17	the	the	DT
cord-300194-nsp53lv6	93	18	protein	protein	NN
cord-300194-nsp53lv6	93	19	comprises	comprise	VBZ
cord-300194-nsp53lv6	93	20	of	of	IN
cord-300194-nsp53lv6	93	21	two	two	CD
cord-300194-nsp53lv6	93	22	distinct	distinct	JJ
cord-300194-nsp53lv6	93	23	domains	domain	NNS
cord-300194-nsp53lv6	93	24	S1	s1	NN
cord-300194-nsp53lv6	93	25	and	and	CC
cord-300194-nsp53lv6	93	26	S2	S2	NNP
cord-300194-nsp53lv6	93	27	,	,	,
cord-300194-nsp53lv6	93	28	we	-PRON-	PRP
cord-300194-nsp53lv6	93	29	checked	check	VBD
cord-300194-nsp53lv6	93	30	the	the	DT
cord-300194-nsp53lv6	93	31	RMSD	RMSD	NNP
cord-300194-nsp53lv6	93	32	of	of	IN
cord-300194-nsp53lv6	93	33	S1	S1	NNP
cord-300194-nsp53lv6	93	34	and	and	CC
cord-300194-nsp53lv6	93	35	S2	s2	NN
cord-300194-nsp53lv6	93	36	domains	domain	NNS
cord-300194-nsp53lv6	93	37	individually	individually	RB
cord-300194-nsp53lv6	93	38	,	,	,
cord-300194-nsp53lv6	93	39	with	with	IN
cord-300194-nsp53lv6	93	40	respect	respect	NN
cord-300194-nsp53lv6	93	41	to	to	IN
cord-300194-nsp53lv6	93	42	the	the	DT
cord-300194-nsp53lv6	93	43	starting	starting	NN
cord-300194-nsp53lv6	93	44	structure	structure	NN
cord-300194-nsp53lv6	93	45	,	,	,
cord-300194-nsp53lv6	93	46	to	to	TO
cord-300194-nsp53lv6	93	47	understand	understand	VB
cord-300194-nsp53lv6	93	48	the	the	DT
cord-300194-nsp53lv6	93	49	ause	ause	NN
cord-300194-nsp53lv6	93	50	for	for	IN
cord-300194-nsp53lv6	93	51	higher	high	JJR
cord-300194-nsp53lv6	93	52	R	r	NN
cord-300194-nsp53lv6	93	53	S	s	NN
cord-300194-nsp53lv6	93	54	values	value	NNS
cord-300194-nsp53lv6	93	55	o	o	NN
cord-300194-nsp53lv6	93	56	served	serve	VBD
cord-300194-nsp53lv6	93	57	at	at	IN
cord-300194-nsp53lv6	93	58	and	and	CC
cord-300194-nsp53lv6	93	59	igure	igure	VB
cord-300194-nsp53lv6	93	60	The	the	DT
cord-300194-nsp53lv6	93	61	R	r	NN
cord-300194-nsp53lv6	93	62	S	S	NNP
cord-300194-nsp53lv6	93	63	values	value	NNS
cord-300194-nsp53lv6	93	64	of	of	IN
cord-300194-nsp53lv6	93	65	S1	s1	NN
cord-300194-nsp53lv6	93	66	domain	domain	NN
cord-300194-nsp53lv6	93	67	at	at	IN
cord-300194-nsp53lv6	93	68	and	and	CC
cord-300194-nsp53lv6	93	69	were	be	VBD
cord-300194-nsp53lv6	93	70	found	find	VBN
cord-300194-nsp53lv6	93	71	to	to	IN
cord-300194-nsp53lv6	93	72	e	e	VB
cord-300194-nsp53lv6	93	73	around	around	RB
cord-300194-nsp53lv6	93	74	nm	nm	NN
cord-300194-nsp53lv6	93	75	nearly	nearly	RB
cord-300194-nsp53lv6	93	76	nm	nm	RB
cord-300194-nsp53lv6	93	77	more	more	JJR
cord-300194-nsp53lv6	93	78	than	than	IN
cord-300194-nsp53lv6	93	79	simulations	simulation	NNS
cord-300194-nsp53lv6	93	80	at	at	IN
cord-300194-nsp53lv6	93	81	1	1	CD
cord-300194-nsp53lv6	93	82	and	and	CC
cord-300194-nsp53lv6	93	83	respe	respe	NNP
cord-300194-nsp53lv6	94	1	tively	tively	NNP
cord-300194-nsp53lv6	94	2	similar	similar	JJ
cord-300194-nsp53lv6	94	3	trend	trend	NN
cord-300194-nsp53lv6	94	4	was	be	VBD
cord-300194-nsp53lv6	94	5	o	o	UH
cord-300194-nsp53lv6	94	6	served	serve	VBN
cord-300194-nsp53lv6	94	7	in	in	IN
cord-300194-nsp53lv6	94	8	the	the	DT
cord-300194-nsp53lv6	94	9	R	R	NNP
cord-300194-nsp53lv6	94	10	S	S	NNP
cord-300194-nsp53lv6	94	11	of	of	IN
cord-300194-nsp53lv6	94	12	S	S	NNP
cord-300194-nsp53lv6	94	13	domain	domain	NN
cord-300194-nsp53lv6	94	14	ut	ut	NN
cord-300194-nsp53lv6	95	1	the	the	DT
cord-300194-nsp53lv6	95	2	differen	differen	NNP
cord-300194-nsp53lv6	95	3	e	e	NN
cord-300194-nsp53lv6	95	4	in	in	IN
cord-300194-nsp53lv6	95	5	values	value	NNS
cord-300194-nsp53lv6	95	6	was	be	VBD
cord-300194-nsp53lv6	95	7	only	only	RB
cord-300194-nsp53lv6	95	8	1	1	CD
cord-300194-nsp53lv6	95	9	nm	nm	CC
cord-300194-nsp53lv6	95	10	lthough	lthough	UH
cord-300194-nsp53lv6	95	11	in	in	IN
cord-300194-nsp53lv6	95	12	this	this	DT
cord-300194-nsp53lv6	95	13	study	study	NN
cord-300194-nsp53lv6	95	14	we	-PRON-	PRP
cord-300194-nsp53lv6	95	15	have	have	VBP
cord-300194-nsp53lv6	95	16	n't	not	RB
cord-300194-nsp53lv6	95	17	considered	consider	VBN
cord-300194-nsp53lv6	95	18	the	the	DT
cord-300194-nsp53lv6	95	19	bilayer	bilayer	NN
cord-300194-nsp53lv6	95	20	lipid	lipid	NN
cord-300194-nsp53lv6	95	21	membrane	membrane	NN
cord-300194-nsp53lv6	95	22	of	of	IN
cord-300194-nsp53lv6	95	23	the	the	DT
cord-300194-nsp53lv6	95	24	SARS	SARS	NNP
cord-300194-nsp53lv6	95	25	-	-	HYPH
cord-300194-nsp53lv6	95	26	COV-2	COV-2	NNP
cord-300194-nsp53lv6	95	27	envelope	envelope	NN
cord-300194-nsp53lv6	95	28	inside	inside	IN
cord-300194-nsp53lv6	95	29	which	which	WDT
cord-300194-nsp53lv6	95	30	the	the	DT
cord-300194-nsp53lv6	95	31	Spike	Spike	NNP
cord-300194-nsp53lv6	95	32	9	9	CD
cord-300194-nsp53lv6	95	33	glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	95	34	resides	reside	VBZ
cord-300194-nsp53lv6	95	35	,	,	,
cord-300194-nsp53lv6	95	36	the	the	DT
cord-300194-nsp53lv6	95	37	S2	S2	NNP
cord-300194-nsp53lv6	95	38	domain	domain	NN
cord-300194-nsp53lv6	95	39	shows	show	VBZ
cord-300194-nsp53lv6	95	40	remarkable	remarkable	JJ
cord-300194-nsp53lv6	95	41	stability	stability	NN
cord-300194-nsp53lv6	95	42	in	in	IN
cord-300194-nsp53lv6	95	43	its	-PRON-	PRP$
cord-300194-nsp53lv6	95	44	RMSD	rmsd	NN
cord-300194-nsp53lv6	95	45	values	value	NNS
cord-300194-nsp53lv6	95	46	(	(	-LRB-
cord-300194-nsp53lv6	95	47	Figure	figure	NN
cord-300194-nsp53lv6	95	48	2	2	CD
cord-300194-nsp53lv6	95	49	)	)	-RRB-
cord-300194-nsp53lv6	95	50	.	.	.
cord-300194-nsp53lv6	96	1	The	the	DT
cord-300194-nsp53lv6	96	2	stability	stability	NN
cord-300194-nsp53lv6	96	3	of	of	IN
cord-300194-nsp53lv6	96	4	the	the	DT
cord-300194-nsp53lv6	96	5	S2	S2	NNP
cord-300194-nsp53lv6	96	6	domain	domain	NN
cord-300194-nsp53lv6	96	7	can	can	MD
cord-300194-nsp53lv6	96	8	be	be	VB
cord-300194-nsp53lv6	96	9	conferred	confer	VBN
cord-300194-nsp53lv6	96	10	to	to	IN
cord-300194-nsp53lv6	96	11	the	the	DT
cord-300194-nsp53lv6	96	12	strong	strong	JJ
cord-300194-nsp53lv6	96	13	interchain	interchain	JJ
cord-300194-nsp53lv6	96	14	interactions	interaction	NNS
cord-300194-nsp53lv6	96	15	among	among	IN
cord-300194-nsp53lv6	96	16	the	the	DT
cord-300194-nsp53lv6	96	17	highly	highly	RB
cord-300194-nsp53lv6	96	18	α	α	NN
cord-300194-nsp53lv6	96	19	-	-	HYPH
cord-300194-nsp53lv6	96	20	helical	helical	JJ
cord-300194-nsp53lv6	96	21	S2	s2	NN
cord-300194-nsp53lv6	96	22	domain	domain	NN
cord-300194-nsp53lv6	96	23	.	.	.
cord-300194-nsp53lv6	97	1	Since	since	IN
cord-300194-nsp53lv6	97	2	the	the	DT
cord-300194-nsp53lv6	97	3	Spike	Spike	NNP
cord-300194-nsp53lv6	97	4	protein	protein	NN
cord-300194-nsp53lv6	97	5	is	be	VBZ
cord-300194-nsp53lv6	97	6	a	a	DT
cord-300194-nsp53lv6	97	7	homotrimer	homotrimer	NN
cord-300194-nsp53lv6	97	8	,	,	,
cord-300194-nsp53lv6	97	9	the	the	DT
cord-300194-nsp53lv6	97	10	S1	S1	NNP
cord-300194-nsp53lv6	97	11	domain	domain	NN
cord-300194-nsp53lv6	97	12	of	of	IN
cord-300194-nsp53lv6	97	13	individual	individual	JJ
cord-300194-nsp53lv6	97	14	domains	domain	NNS
cord-300194-nsp53lv6	97	15	was	be	VBD
cord-300194-nsp53lv6	97	16	also	also	RB
cord-300194-nsp53lv6	97	17	checked	check	VBN
cord-300194-nsp53lv6	97	18	to	to	TO
cord-300194-nsp53lv6	97	19	account	account	VB
cord-300194-nsp53lv6	97	20	for	for	IN
cord-300194-nsp53lv6	97	21	the	the	DT
cord-300194-nsp53lv6	97	22	difference	difference	NN
cord-300194-nsp53lv6	97	23	in	in	IN
cord-300194-nsp53lv6	97	24	fluctuations	fluctuation	NNS
cord-300194-nsp53lv6	97	25	.	.	.
cord-300194-nsp53lv6	98	1	Figure	figure	NN
cord-300194-nsp53lv6	98	2	2	2	CD
cord-300194-nsp53lv6	98	3	(	(	-LRB-
cord-300194-nsp53lv6	98	4	c	c	NN
cord-300194-nsp53lv6	98	5	)	)	-RRB-
cord-300194-nsp53lv6	98	6	-(e	-(e	.
cord-300194-nsp53lv6	98	7	)	)	-RRB-
cord-300194-nsp53lv6	98	8	shows	show	VBZ
cord-300194-nsp53lv6	98	9	the	the	DT
cord-300194-nsp53lv6	98	10	RMSD	RMSD	NNP
cord-300194-nsp53lv6	98	11	of	of	IN
cord-300194-nsp53lv6	98	12	S1	s1	NN
cord-300194-nsp53lv6	98	13	domain	domain	NN
cord-300194-nsp53lv6	98	14	of	of	IN
cord-300194-nsp53lv6	98	15	chains	chain	NNS
cord-300194-nsp53lv6	99	1	A	a	LS
cord-300194-nsp53lv6	99	2	,	,	,
cord-300194-nsp53lv6	99	3	B	b	NN
cord-300194-nsp53lv6	99	4	and	and	CC
cord-300194-nsp53lv6	99	5	C	c	NN
cord-300194-nsp53lv6	99	6	at	at	IN
cord-300194-nsp53lv6	99	7	different	different	JJ
cord-300194-nsp53lv6	99	8	temperatures	temperature	NNS
cord-300194-nsp53lv6	99	9	.	.	.
cord-300194-nsp53lv6	100	1	In	in	IN
cord-300194-nsp53lv6	100	2	chain	chain	NN
cord-300194-nsp53lv6	100	3	A	A	NNP
cord-300194-nsp53lv6	100	4	,	,	,
cord-300194-nsp53lv6	100	5	it	-PRON-	PRP
cord-300194-nsp53lv6	100	6	can	can	MD
cord-300194-nsp53lv6	100	7	be	be	VB
cord-300194-nsp53lv6	100	8	clearly	clearly	RB
cord-300194-nsp53lv6	100	9	seen	see	VBN
cord-300194-nsp53lv6	100	10	how	how	WRB
cord-300194-nsp53lv6	100	11	the	the	DT
cord-300194-nsp53lv6	100	12	RMSD	RMSD	NNP
cord-300194-nsp53lv6	100	13	is	be	VBZ
cord-300194-nsp53lv6	100	14	quite	quite	RB
cord-300194-nsp53lv6	100	15	high	high	JJ
cord-300194-nsp53lv6	100	16	at	at	IN
cord-300194-nsp53lv6	100	17	temperatures	temperature	NNS
cord-300194-nsp53lv6	100	18	of	of	IN
cord-300194-nsp53lv6	100	19	30	30	CD
cord-300194-nsp53lv6	100	20	C	C	NNP
cord-300194-nsp53lv6	100	21	and	and	CC
cord-300194-nsp53lv6	100	22	respe	respe	NNP
cord-300194-nsp53lv6	100	23	tively	tively	NNP
cord-300194-nsp53lv6	100	24	t	t	NNP
cord-300194-nsp53lv6	100	25	C	C	NNP
cord-300194-nsp53lv6	100	26	however	however	RB
cord-300194-nsp53lv6	100	27	,	,	,
cord-300194-nsp53lv6	100	28	the	the	DT
cord-300194-nsp53lv6	100	29	fluctuations	fluctuation	NNS
cord-300194-nsp53lv6	100	30	are	be	VBP
cord-300194-nsp53lv6	100	31	quite	quite	RB
cord-300194-nsp53lv6	100	32	negligible	negligible	JJ
cord-300194-nsp53lv6	100	33	and	and	CC
cord-300194-nsp53lv6	100	34	the	the	DT
cord-300194-nsp53lv6	100	35	system	system	NN
cord-300194-nsp53lv6	100	36	is	be	VBZ
cord-300194-nsp53lv6	100	37	very	very	RB
cord-300194-nsp53lv6	100	38	stable	stable	JJ
cord-300194-nsp53lv6	100	39	.	.	.
cord-300194-nsp53lv6	101	1	Similarly	similarly	RB
cord-300194-nsp53lv6	101	2	,	,	,
cord-300194-nsp53lv6	101	3	for	for	IN
cord-300194-nsp53lv6	101	4	chain	chain	NN
cord-300194-nsp53lv6	101	5	B	b	NN
cord-300194-nsp53lv6	101	6	at	at	IN
cord-300194-nsp53lv6	101	7	10	10	CD
cord-300194-nsp53lv6	101	8	and	and	CC
cord-300194-nsp53lv6	101	9	the	the	DT
cord-300194-nsp53lv6	101	10	chains	chain	NNS
cord-300194-nsp53lv6	101	11	were	be	VBD
cord-300194-nsp53lv6	101	12	stable	stable	JJ
cord-300194-nsp53lv6	101	13	.	.	.
cord-300194-nsp53lv6	102	1	In	in	IN
cord-300194-nsp53lv6	102	2	the	the	DT
cord-300194-nsp53lv6	102	3	S1	S1	NNP
cord-300194-nsp53lv6	102	4	domain	domain	NN
cord-300194-nsp53lv6	102	5	of	of	IN
cord-300194-nsp53lv6	102	6	chain	chain	NN
cord-300194-nsp53lv6	102	7	C	c	NN
cord-300194-nsp53lv6	102	8	,	,	,
cord-300194-nsp53lv6	102	9	except	except	IN
cord-300194-nsp53lv6	102	10	for	for	IN
cord-300194-nsp53lv6	102	11	simulation	simulation	NN
cord-300194-nsp53lv6	102	12	at	at	IN
cord-300194-nsp53lv6	102	13	40	40	CD
cord-300194-nsp53lv6	102	14	C	C	NNP
cord-300194-nsp53lv6	102	15	,	,	,
cord-300194-nsp53lv6	102	16	at	at	IN
cord-300194-nsp53lv6	102	17	all	all	DT
cord-300194-nsp53lv6	102	18	other	other	JJ
cord-300194-nsp53lv6	102	19	temperatures	temperature	NNS
cord-300194-nsp53lv6	102	20	,	,	,
cord-300194-nsp53lv6	102	21	the	the	DT
cord-300194-nsp53lv6	102	22	RMSD	rmsd	NN
cord-300194-nsp53lv6	102	23	values	value	NNS
cord-300194-nsp53lv6	102	24	were	be	VBD
cord-300194-nsp53lv6	102	25	found	find	VBN
cord-300194-nsp53lv6	102	26	to	to	TO
cord-300194-nsp53lv6	102	27	be	be	VB
cord-300194-nsp53lv6	102	28	quite	quite	RB
cord-300194-nsp53lv6	102	29	low	low	JJ
cord-300194-nsp53lv6	102	30	along	along	IN
cord-300194-nsp53lv6	102	31	the	the	DT
cord-300194-nsp53lv6	102	32	length	length	NN
cord-300194-nsp53lv6	102	33	of	of	IN
cord-300194-nsp53lv6	102	34	the	the	DT
cord-300194-nsp53lv6	102	35	simulation	simulation	NN
cord-300194-nsp53lv6	102	36	time	time	NN
cord-300194-nsp53lv6	102	37	.	.	.
cord-300194-nsp53lv6	103	1	The	the	DT
cord-300194-nsp53lv6	103	2	above	above	JJ
cord-300194-nsp53lv6	103	3	data	data	NN
cord-300194-nsp53lv6	103	4	indicates	indicate	VBZ
cord-300194-nsp53lv6	103	5	that	that	IN
cord-300194-nsp53lv6	103	6	the	the	DT
cord-300194-nsp53lv6	103	7	protein	protein	NN
cord-300194-nsp53lv6	103	8	chains	chain	NNS
cord-300194-nsp53lv6	103	9	,	,	,
cord-300194-nsp53lv6	103	10	especially	especially	RB
cord-300194-nsp53lv6	103	11	the	the	DT
cord-300194-nsp53lv6	103	12	S1	s1	NN
cord-300194-nsp53lv6	103	13	domains	domain	NNS
cord-300194-nsp53lv6	103	14	are	be	VBP
cord-300194-nsp53lv6	103	15	quite	quite	RB
cord-300194-nsp53lv6	103	16	flexible	flexible	JJ
cord-300194-nsp53lv6	103	17	around	around	IN
cord-300194-nsp53lv6	103	18	the	the	DT
cord-300194-nsp53lv6	103	19	temperatures	temperature	NNS
cord-300194-nsp53lv6	103	20	of	of	IN
cord-300194-nsp53lv6	103	21	20	20	CD
cord-300194-nsp53lv6	103	22	-	-	SYM
cord-300194-nsp53lv6	103	23	40	40	CD
cord-300194-nsp53lv6	103	24	C	c	NN
cord-300194-nsp53lv6	103	25	in	in	IN
cord-300194-nsp53lv6	103	26	comparison	comparison	NN
cord-300194-nsp53lv6	103	27	to	to	IN
cord-300194-nsp53lv6	103	28	low	low	JJ
cord-300194-nsp53lv6	103	29	temperatures	temperature	NNS
cord-300194-nsp53lv6	103	30	of	of	IN
cord-300194-nsp53lv6	103	31	10	10	CD
cord-300194-nsp53lv6	103	32	or	or	CC
cord-300194-nsp53lv6	103	33	high	high	JJ
cord-300194-nsp53lv6	103	34	of	of	IN
cord-300194-nsp53lv6	103	35	simulation	simulation	NN
cord-300194-nsp53lv6	103	36	temperature	temperature	NN
cord-300194-nsp53lv6	103	37	rrespe	rrespe	NN
cord-300194-nsp53lv6	103	38	tive	tive	JJ
cord-300194-nsp53lv6	103	39	of	of	IN
cord-300194-nsp53lv6	103	40	the	the	DT
cord-300194-nsp53lv6	103	41	presen	presen	NNP
cord-300194-nsp53lv6	103	42	e	e	NNP
cord-300194-nsp53lv6	103	43	of	of	IN
cord-300194-nsp53lv6	103	44	the	the	DT
cord-300194-nsp53lv6	103	45	ilayer	ilayer	NNP
cord-300194-nsp53lv6	103	46	mem	mem	NNP
cord-300194-nsp53lv6	103	47	rane	rane	NNP
cord-300194-nsp53lv6	103	48	at	at	IN
cord-300194-nsp53lv6	103	49	different	different	JJ
cord-300194-nsp53lv6	103	50	temperature	temperature	NN
cord-300194-nsp53lv6	103	51	conditions	condition	NNS
cord-300194-nsp53lv6	103	52	,	,	,
cord-300194-nsp53lv6	103	53	the	the	DT
cord-300194-nsp53lv6	103	54	stalk	stalk	NN
cord-300194-nsp53lv6	103	55	of	of	IN
cord-300194-nsp53lv6	103	56	the	the	DT
cord-300194-nsp53lv6	103	57	Spike	Spike	NNP
cord-300194-nsp53lv6	103	58	protein	protein	NN
cord-300194-nsp53lv6	103	59	remains	remain	VBZ
cord-300194-nsp53lv6	103	60	stable	stable	JJ
cord-300194-nsp53lv6	103	61	.	.	.
cord-300194-nsp53lv6	104	1	B.	B.	NNP
cord-300194-nsp53lv6	104	2	Domain	Domain	NNP
cord-300194-nsp53lv6	104	3	flexibility	flexibility	NN
cord-300194-nsp53lv6	104	4	of	of	IN
cord-300194-nsp53lv6	104	5	S1	s1	NN
cord-300194-nsp53lv6	104	6	is	be	VBZ
cord-300194-nsp53lv6	104	7	more	more	RBR
cord-300194-nsp53lv6	104	8	pronounced	pronounced	JJ
cord-300194-nsp53lv6	105	1	In	in	IN
cord-300194-nsp53lv6	105	2	order	order	NN
cord-300194-nsp53lv6	105	3	to	to	TO
cord-300194-nsp53lv6	105	4	identify	identify	VB
cord-300194-nsp53lv6	105	5	the	the	DT
cord-300194-nsp53lv6	105	6	region	region	NN
cord-300194-nsp53lv6	105	7	on	on	IN
cord-300194-nsp53lv6	105	8	the	the	DT
cord-300194-nsp53lv6	105	9	Spike	Spike	NNP
cord-300194-nsp53lv6	105	10	protein	protein	NN
cord-300194-nsp53lv6	105	11	that	that	WDT
cord-300194-nsp53lv6	105	12	causes	cause	VBZ
cord-300194-nsp53lv6	105	13	the	the	DT
cord-300194-nsp53lv6	105	14	deviations	deviation	NNS
cord-300194-nsp53lv6	105	15	in	in	IN
cord-300194-nsp53lv6	105	16	RMSDs	rmsd	NNS
cord-300194-nsp53lv6	105	17	,	,	,
cord-300194-nsp53lv6	105	18	we	-PRON-	PRP
cord-300194-nsp53lv6	105	19	The	the	DT
cord-300194-nsp53lv6	105	20	RMSF	RMSF	NNP
cord-300194-nsp53lv6	105	21	of	of	IN
cord-300194-nsp53lv6	105	22	S2	S2	NNP
cord-300194-nsp53lv6	105	23	domain	domain	NN
cord-300194-nsp53lv6	105	24	on	on	IN
cord-300194-nsp53lv6	105	25	the	the	DT
cord-300194-nsp53lv6	105	26	other	other	JJ
cord-300194-nsp53lv6	105	27	hand	hand	NN
cord-300194-nsp53lv6	105	28	shows	show	NNS
cord-300194-nsp53lv6	105	29	marked	mark	VBN
cord-300194-nsp53lv6	105	30	stability	stability	NN
cord-300194-nsp53lv6	105	31	compared	compare	VBN
cord-300194-nsp53lv6	105	32	to	to	IN
cord-300194-nsp53lv6	105	33	domain	domain	NN
cord-300194-nsp53lv6	105	34	S1	s1	NN
cord-300194-nsp53lv6	105	35	(	(	-LRB-
cord-300194-nsp53lv6	105	36	Figure	figure	NN
cord-300194-nsp53lv6	105	37	S4	S4	NNP
cord-300194-nsp53lv6	105	38	)	)	-RRB-
cord-300194-nsp53lv6	105	39	.	.	.
cord-300194-nsp53lv6	106	1	This	this	DT
cord-300194-nsp53lv6	106	2	is	be	VBZ
cord-300194-nsp53lv6	106	3	in	in	IN
cord-300194-nsp53lv6	106	4	good	good	JJ
cord-300194-nsp53lv6	106	5	agreement	agreement	NN
cord-300194-nsp53lv6	106	6	to	to	IN
cord-300194-nsp53lv6	106	7	our	-PRON-	PRP$
cord-300194-nsp53lv6	106	8	earlier	early	JJR
cord-300194-nsp53lv6	106	9	observations	observation	NNS
cord-300194-nsp53lv6	106	10	of	of	IN
cord-300194-nsp53lv6	106	11	the	the	DT
cord-300194-nsp53lv6	106	12	RMSD	RMSD	NNP
cord-300194-nsp53lv6	106	13	of	of	IN
cord-300194-nsp53lv6	106	14	the	the	DT
cord-300194-nsp53lv6	106	15	S2	S2	NNP
cord-300194-nsp53lv6	106	16	domain	domain	NN
cord-300194-nsp53lv6	106	17	.	.	.
cord-300194-nsp53lv6	107	1	Since	since	IN
cord-300194-nsp53lv6	107	2	it	-PRON-	PRP
cord-300194-nsp53lv6	107	3	is	be	VBZ
cord-300194-nsp53lv6	107	4	a	a	DT
cord-300194-nsp53lv6	107	5	triple	triple	JJ
cord-300194-nsp53lv6	107	6	helical	helical	JJ
cord-300194-nsp53lv6	107	7	coil	coil	NN
cord-300194-nsp53lv6	107	8	,	,	,
cord-300194-nsp53lv6	107	9	the	the	DT
cord-300194-nsp53lv6	107	10	coiled	coil	VBN
cord-300194-nsp53lv6	107	11	-	-	HYPH
cord-300194-nsp53lv6	107	12	coil	coil	NN
cord-300194-nsp53lv6	107	13	motif	motif	NN
cord-300194-nsp53lv6	107	14	of	of	IN
cord-300194-nsp53lv6	107	15	the	the	DT
cord-300194-nsp53lv6	107	16	S2	S2	NNP
cord-300194-nsp53lv6	107	17	domain	domain	NN
cord-300194-nsp53lv6	107	18	which	which	WDT
cord-300194-nsp53lv6	107	19	is	be	VBZ
cord-300194-nsp53lv6	107	20	further	further	RB
cord-300194-nsp53lv6	107	21	supported	support	VBN
cord-300194-nsp53lv6	107	22	by	by	IN
cord-300194-nsp53lv6	107	23	three	three	CD
cord-300194-nsp53lv6	107	24	shorter	short	JJR
cord-300194-nsp53lv6	107	25	helices	helix	NNS
cord-300194-nsp53lv6	107	26	supports	support	VBZ
cord-300194-nsp53lv6	107	27	domain	domain	NN
cord-300194-nsp53lv6	107	28	stability	stability	NN
cord-300194-nsp53lv6	107	29	[	[	-LRB-
cord-300194-nsp53lv6	107	30	29	29	CD
cord-300194-nsp53lv6	107	31	]	]	-RRB-
cord-300194-nsp53lv6	107	32	.	.	.
cord-300194-nsp53lv6	108	1	However	however	RB
cord-300194-nsp53lv6	108	2	,	,	,
cord-300194-nsp53lv6	108	3	the	the	DT
cord-300194-nsp53lv6	108	4	C	c	NN
cord-300194-nsp53lv6	108	5	-	-	HYPH
cord-300194-nsp53lv6	108	6	terminal	terminal	NN
cord-300194-nsp53lv6	108	7	residues	residue	NNS
cord-300194-nsp53lv6	108	8	1125	1125	CD
cord-300194-nsp53lv6	108	9	-	-	SYM
cord-300194-nsp53lv6	108	10	1273	1273	CD
cord-300194-nsp53lv6	108	11	show	show	VBP
cord-300194-nsp53lv6	108	12	greater	great	JJR
cord-300194-nsp53lv6	108	13	flexibility	flexibility	NN
cord-300194-nsp53lv6	108	14	compared	compare	VBN
cord-300194-nsp53lv6	108	15	to	to	IN
cord-300194-nsp53lv6	108	16	the	the	DT
cord-300194-nsp53lv6	108	17	rest	rest	NN
cord-300194-nsp53lv6	108	18	of	of	IN
cord-300194-nsp53lv6	108	19	the	the	DT
cord-300194-nsp53lv6	108	20	domain	domain	NN
cord-300194-nsp53lv6	108	21	.	.	.
cord-300194-nsp53lv6	109	1	It	-PRON-	PRP
cord-300194-nsp53lv6	109	2	should	should	MD
cord-300194-nsp53lv6	109	3	be	be	VB
cord-300194-nsp53lv6	109	4	noted	note	VBN
cord-300194-nsp53lv6	109	5	that	that	IN
cord-300194-nsp53lv6	109	6	the	the	DT
cord-300194-nsp53lv6	109	7	C-	C-	NNP
cord-300194-nsp53lv6	109	8	11	11	CD
cord-300194-nsp53lv6	109	9	terminal	terminal	NN
cord-300194-nsp53lv6	109	10	region	region	NN
cord-300194-nsp53lv6	109	11	of	of	IN
cord-300194-nsp53lv6	109	12	the	the	DT
cord-300194-nsp53lv6	109	13	Spike	Spike	NNP
cord-300194-nsp53lv6	109	14	glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	109	15	is	be	VBZ
cord-300194-nsp53lv6	109	16	exposed	expose	VBN
cord-300194-nsp53lv6	109	17	towards	towards	IN
cord-300194-nsp53lv6	109	18	the	the	DT
cord-300194-nsp53lv6	109	19	inner	inner	JJ
cord-300194-nsp53lv6	109	20	side	side	NN
cord-300194-nsp53lv6	109	21	of	of	IN
cord-300194-nsp53lv6	109	22	the	the	DT
cord-300194-nsp53lv6	109	23	envelope	envelope	NN
cord-300194-nsp53lv6	109	24	bilayer	bilayer	NN
cord-300194-nsp53lv6	109	25	and	and	CC
cord-300194-nsp53lv6	109	26	does	do	VBZ
cord-300194-nsp53lv6	109	27	not	not	RB
cord-300194-nsp53lv6	109	28	participate	participate	VB
cord-300194-nsp53lv6	109	29	in	in	IN
cord-300194-nsp53lv6	109	30	the	the	DT
cord-300194-nsp53lv6	109	31	interchain	interchain	JJ
cord-300194-nsp53lv6	109	32	interactions	interaction	NNS
cord-300194-nsp53lv6	109	33	.	.	.
cord-300194-nsp53lv6	110	1	It	-PRON-	PRP
cord-300194-nsp53lv6	110	2	also	also	RB
cord-300194-nsp53lv6	110	3	has	have	VBZ
cord-300194-nsp53lv6	110	4	a	a	DT
cord-300194-nsp53lv6	110	5	more	more	RBR
cord-300194-nsp53lv6	110	6	relaxed	relaxed	JJ
cord-300194-nsp53lv6	110	7	packing	packing	NN
cord-300194-nsp53lv6	110	8	compared	compare	VBN
cord-300194-nsp53lv6	110	9	to	to	IN
cord-300194-nsp53lv6	110	10	the	the	DT
cord-300194-nsp53lv6	110	11	rest	rest	NN
cord-300194-nsp53lv6	110	12	of	of	IN
cord-300194-nsp53lv6	110	13	the	the	DT
cord-300194-nsp53lv6	110	14	S2	s2	NN
cord-300194-nsp53lv6	110	15	[	[	-LRB-
cord-300194-nsp53lv6	110	16	28	28	CD
cord-300194-nsp53lv6	110	17	,	,	,
cord-300194-nsp53lv6	110	18	30	30	CD
cord-300194-nsp53lv6	110	19	]	]	-RRB-
cord-300194-nsp53lv6	110	20	.	.	.
cord-300194-nsp53lv6	111	1	Although	although	IN
cord-300194-nsp53lv6	111	2	,	,	,
cord-300194-nsp53lv6	111	3	the	the	DT
cord-300194-nsp53lv6	111	4	NTD	NTD	NNP
cord-300194-nsp53lv6	111	5	is	be	VBZ
cord-300194-nsp53lv6	111	6	not	not	RB
cord-300194-nsp53lv6	111	7	known	know	VBN
cord-300194-nsp53lv6	111	8	to	to	TO
cord-300194-nsp53lv6	111	9	directly	directly	RB
cord-300194-nsp53lv6	111	10	bind	bind	VB
cord-300194-nsp53lv6	111	11	to	to	IN
cord-300194-nsp53lv6	111	12	the	the	DT
cord-300194-nsp53lv6	111	13	receptor	receptor	NN
cord-300194-nsp53lv6	111	14	,	,	,
cord-300194-nsp53lv6	111	15	in	in	IN
cord-300194-nsp53lv6	111	16	Mouse	Mouse	NNP
cord-300194-nsp53lv6	111	17	hepatitis	hepatitis	NN
cord-300194-nsp53lv6	111	18	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	111	19	,	,	,
cord-300194-nsp53lv6	111	20	it	-PRON-	PRP
cord-300194-nsp53lv6	111	21	was	be	VBD
cord-300194-nsp53lv6	111	22	found	find	VBN
cord-300194-nsp53lv6	111	23	that	that	IN
cord-300194-nsp53lv6	111	24	the	the	DT
cord-300194-nsp53lv6	111	25	NTD	NTD	NNP
cord-300194-nsp53lv6	111	26	binds	bind	VBZ
cord-300194-nsp53lv6	111	27	to	to	IN
cord-300194-nsp53lv6	111	28	a	a	DT
cord-300194-nsp53lv6	111	29	CEACAM1a	ceacam1a	NN
cord-300194-nsp53lv6	111	30	receptor	receptor	NN
cord-300194-nsp53lv6	111	31	[	[	-LRB-
cord-300194-nsp53lv6	111	32	31	31	CD
cord-300194-nsp53lv6	111	33	]	]	-RRB-
cord-300194-nsp53lv6	111	34	.	.	.
cord-300194-nsp53lv6	112	1	Similarly	similarly	RB
cord-300194-nsp53lv6	112	2	,	,	,
cord-300194-nsp53lv6	112	3	vaccines	vaccine	NNS
cord-300194-nsp53lv6	112	4	developed	develop	VBN
cord-300194-nsp53lv6	112	5	against	against	IN
cord-300194-nsp53lv6	112	6	the	the	DT
cord-300194-nsp53lv6	112	7	NTD	NTD	NNP
cord-300194-nsp53lv6	112	8	of	of	IN
cord-300194-nsp53lv6	112	9	Spike	Spike	NNP
cord-300194-nsp53lv6	112	10	protein	protein	NN
cord-300194-nsp53lv6	112	11	in	in	IN
cord-300194-nsp53lv6	112	12	mice	mouse	NNS
cord-300194-nsp53lv6	112	13	,	,	,
cord-300194-nsp53lv6	112	14	had	have	VBD
cord-300194-nsp53lv6	112	15	shown	show	VBN
cord-300194-nsp53lv6	112	16	that	that	IN
cord-300194-nsp53lv6	112	17	NTD	NTD	NNP
cord-300194-nsp53lv6	112	18	can	can	MD
cord-300194-nsp53lv6	112	19	also	also	RB
cord-300194-nsp53lv6	112	20	be	be	VB
cord-300194-nsp53lv6	112	21	a	a	DT
cord-300194-nsp53lv6	112	22	potential	potential	JJ
cord-300194-nsp53lv6	112	23	therapeutic	therapeutic	JJ
cord-300194-nsp53lv6	112	24	target	target	NN
cord-300194-nsp53lv6	112	25	[	[	-LRB-
cord-300194-nsp53lv6	112	26	32	32	CD
cord-300194-nsp53lv6	112	27	,	,	,
cord-300194-nsp53lv6	112	28	33	33	CD
cord-300194-nsp53lv6	112	29	]	]	-RRB-
cord-300194-nsp53lv6	112	30	.	.	.
cord-300194-nsp53lv6	113	1	Moreover	moreover	RB
cord-300194-nsp53lv6	113	2	,	,	,
cord-300194-nsp53lv6	113	3	comparison	comparison	NN
cord-300194-nsp53lv6	113	4	between	between	IN
cord-300194-nsp53lv6	113	5	Bovine	bovine	JJ
cord-300194-nsp53lv6	113	6	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	113	7	and	and	CC
cord-300194-nsp53lv6	113	8	Bovine	bovine	JJ
cord-300194-nsp53lv6	113	9	hemagglutinin	hemagglutinin	NN
cord-300194-nsp53lv6	113	10	-	-	HYPH
cord-300194-nsp53lv6	113	11	esterase	esterase	NN
cord-300194-nsp53lv6	113	12	enzyme	enzyme	NN
cord-300194-nsp53lv6	113	13	indicated	indicate	VBD
cord-300194-nsp53lv6	113	14	close	close	JJ
cord-300194-nsp53lv6	113	15	evolutionary	evolutionary	JJ
cord-300194-nsp53lv6	113	16	link	link	NN
cord-300194-nsp53lv6	113	17	between	between	IN
cord-300194-nsp53lv6	113	18	the	the	DT
cord-300194-nsp53lv6	113	19	virus	virus	NN
cord-300194-nsp53lv6	113	20	and	and	CC
cord-300194-nsp53lv6	113	21	the	the	DT
cord-300194-nsp53lv6	113	22	host	host	NN
cord-300194-nsp53lv6	113	23	proteins	protein	NNS
cord-300194-nsp53lv6	113	24	,	,	,
cord-300194-nsp53lv6	113	25	which	which	WDT
cord-300194-nsp53lv6	113	26	could	could	MD
cord-300194-nsp53lv6	113	27	facilitate	facilitate	VB
cord-300194-nsp53lv6	113	28	attachment	attachment	NN
cord-300194-nsp53lv6	113	29	in	in	IN
cord-300194-nsp53lv6	113	30	the	the	DT
cord-300194-nsp53lv6	113	31	host	host	NN
cord-300194-nsp53lv6	113	32	cells	cell	NNS
cord-300194-nsp53lv6	113	33	[	[	-LRB-
cord-300194-nsp53lv6	113	34	34	34	CD
cord-300194-nsp53lv6	113	35	]	]	-RRB-
cord-300194-nsp53lv6	113	36	.	.	.
cord-300194-nsp53lv6	114	1	We	-PRON-	PRP
cord-300194-nsp53lv6	114	2	performed	perform	VBD
cord-300194-nsp53lv6	114	3	a	a	DT
cord-300194-nsp53lv6	114	4	Multiple	multiple	NN
cord-300194-nsp53lv6	115	1	The	the	DT
cord-300194-nsp53lv6	115	2	NTD	NTD	NNP
cord-300194-nsp53lv6	115	3	is	be	VBZ
cord-300194-nsp53lv6	115	4	relatively	relatively	RB
cord-300194-nsp53lv6	115	5	more	more	RBR
cord-300194-nsp53lv6	115	6	exposed	expose	VBN
cord-300194-nsp53lv6	115	7	to	to	IN
cord-300194-nsp53lv6	115	8	solvents	solvent	NNS
cord-300194-nsp53lv6	115	9	and	and	CC
cord-300194-nsp53lv6	115	10	more	more	RBR
cord-300194-nsp53lv6	115	11	susceptible	susceptible	JJ
cord-300194-nsp53lv6	115	12	to	to	IN
cord-300194-nsp53lv6	115	13	external	external	JJ
cord-300194-nsp53lv6	115	14	environmental	environmental	JJ
cord-300194-nsp53lv6	115	15	conditions	condition	NNS
cord-300194-nsp53lv6	115	16	.	.	.
cord-300194-nsp53lv6	116	1	However	however	RB
cord-300194-nsp53lv6	116	2	unlike	unlike	IN
cord-300194-nsp53lv6	116	3	RBD	RBD	NNP
cord-300194-nsp53lv6	116	4	,	,	,
cord-300194-nsp53lv6	116	5	the	the	DT
cord-300194-nsp53lv6	116	6	NT	NT	NNP
cord-300194-nsp53lv6	116	7	does	do	VBZ
cord-300194-nsp53lv6	116	8	n't	not	RB
cord-300194-nsp53lv6	116	9	have	have	VB
cord-300194-nsp53lv6	116	10	a	a	DT
cord-300194-nsp53lv6	116	11	defined	define	VBN
cord-300194-nsp53lv6	116	12	open	open	JJ
cord-300194-nsp53lv6	116	13	or	or	CC
cord-300194-nsp53lv6	116	14	losed	losed	JJ
cord-300194-nsp53lv6	116	15	onformation	onformation	NN
cord-300194-nsp53lv6	117	1	The	the	DT
cord-300194-nsp53lv6	117	2	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	117	3	NTD	NTD	NNP
cord-300194-nsp53lv6	117	4	is	be	VBZ
cord-300194-nsp53lv6	117	5	composed	compose	VBN
cord-300194-nsp53lv6	117	6	of	of	IN
cord-300194-nsp53lv6	117	7	three	three	CD
cord-300194-nsp53lv6	117	8	layered	layered	JJ
cord-300194-nsp53lv6	117	9	beta	beta	NN
cord-300194-nsp53lv6	117	10	-	-	HYPH
cord-300194-nsp53lv6	117	11	sheet	sheet	NN
cord-300194-nsp53lv6	117	12	sandwich	sandwich	NN
cord-300194-nsp53lv6	117	13	with	with	IN
cord-300194-nsp53lv6	117	14	7	7	CD
cord-300194-nsp53lv6	117	15	,	,	,
cord-300194-nsp53lv6	117	16	3	3	CD
cord-300194-nsp53lv6	117	17	and	and	CC
cord-300194-nsp53lv6	117	18	6	6	CD
cord-300194-nsp53lv6	118	1	antiparallel	antiparallel	IN
cord-300194-nsp53lv6	118	2	β	β	NN
cord-300194-nsp53lv6	118	3	strands	strand	NNS
cord-300194-nsp53lv6	118	4	in	in	IN
cord-300194-nsp53lv6	118	5	ea	ea	NNP
cord-300194-nsp53lv6	118	6	h	h	NNP
cord-300194-nsp53lv6	118	7	layer	layer	NN
cord-300194-nsp53lv6	118	8	making	make	VBG
cord-300194-nsp53lv6	118	9	it	-PRON-	PRP
cord-300194-nsp53lv6	118	10	a	a	DT
cord-300194-nsp53lv6	118	11	total	total	NN
cord-300194-nsp53lv6	118	12	of	of	IN
cord-300194-nsp53lv6	118	13	1	1	CD
cord-300194-nsp53lv6	118	14	eta	eta	NNP
cord-300194-nsp53lv6	118	15	stranded	strand	VBN
cord-300194-nsp53lv6	118	16	sheet	sheet	NN
cord-300194-nsp53lv6	118	17	with	with	IN
cord-300194-nsp53lv6	118	18	prominent	prominent	JJ
cord-300194-nsp53lv6	118	19	β	β	NNP
cord-300194-nsp53lv6	118	20	hairpin	hairpin	JJ
cord-300194-nsp53lv6	118	21	loops	loop	NNS
cord-300194-nsp53lv6	118	22	(	(	-LRB-
cord-300194-nsp53lv6	118	23	Figure	figure	NN
cord-300194-nsp53lv6	118	24	S5	S5	NNP
cord-300194-nsp53lv6	118	25	)	)	-RRB-
cord-300194-nsp53lv6	118	26	.	.	.
cord-300194-nsp53lv6	119	1	The	the	DT
cord-300194-nsp53lv6	119	2	crystal	crystal	NN
cord-300194-nsp53lv6	119	3	structures	structure	NNS
cord-300194-nsp53lv6	119	4	of	of	IN
cord-300194-nsp53lv6	119	5	Mouse	Mouse	NNP
cord-300194-nsp53lv6	119	6	Hepatitis	Hepatitis	NNP
cord-300194-nsp53lv6	119	7	Coronavirus	Coronavirus	NNP
cord-300194-nsp53lv6	119	8	(	(	-LRB-
cord-300194-nsp53lv6	119	9	MHC	MHC	NNP
cord-300194-nsp53lv6	119	10	)	)	-RRB-
cord-300194-nsp53lv6	119	11	Spike	spike	NN
cord-300194-nsp53lv6	119	12	protein	protein	NN
cord-300194-nsp53lv6	119	13	and	and	CC
cord-300194-nsp53lv6	119	14	its	-PRON-	PRP$
cord-300194-nsp53lv6	119	15	re	re	NNP
cord-300194-nsp53lv6	119	16	eptor	eptor	NNP
cord-300194-nsp53lv6	119	17	shows	show	VBZ
cord-300194-nsp53lv6	119	18	that	that	IN
cord-300194-nsp53lv6	119	19	the	the	DT
cord-300194-nsp53lv6	119	20	β1	β1	NNP
cord-300194-nsp53lv6	119	21	and	and	CC
cord-300194-nsp53lv6	119	22	β	β	NN
cord-300194-nsp53lv6	119	23	of	of	IN
cord-300194-nsp53lv6	119	24	the	the	DT
cord-300194-nsp53lv6	119	25	NTD	NTD	NNP
cord-300194-nsp53lv6	119	26	are	be	VBP
cord-300194-nsp53lv6	119	27	the	the	DT
cord-300194-nsp53lv6	119	28	binding	binding	JJ
cord-300194-nsp53lv6	119	29	motif	motif	NN
cord-300194-nsp53lv6	119	30	for	for	IN
cord-300194-nsp53lv6	119	31	CECAM1a	cecam1a	JJ
cord-300194-nsp53lv6	119	32	protein	protein	NN
cord-300194-nsp53lv6	119	33	[	[	-LRB-
cord-300194-nsp53lv6	119	34	31	31	CD
cord-300194-nsp53lv6	119	35	]	]	-RRB-
cord-300194-nsp53lv6	119	36	.	.	.
cord-300194-nsp53lv6	120	1	However	however	RB
cord-300194-nsp53lv6	120	2	,	,	,
cord-300194-nsp53lv6	120	3	unlike	unlike	IN
cord-300194-nsp53lv6	120	4	the	the	DT
cord-300194-nsp53lv6	120	5	MHC	MHC	NNP
cord-300194-nsp53lv6	120	6	NTD	NTD	NNP
cord-300194-nsp53lv6	120	7	,	,	,
cord-300194-nsp53lv6	120	8	the	the	DT
cord-300194-nsp53lv6	120	9	arrangement	arrangement	NN
cord-300194-nsp53lv6	120	10	of	of	IN
cord-300194-nsp53lv6	120	11	strands	strand	NNS
cord-300194-nsp53lv6	120	12	in	in	IN
cord-300194-nsp53lv6	120	13	SARS	SARS	NNP
cord-300194-nsp53lv6	120	14	-	-	HYPH
cord-300194-nsp53lv6	120	15	CoV-2	CoV-2	NNP
cord-300194-nsp53lv6	120	16	is	be	VBZ
cord-300194-nsp53lv6	120	17	in	in	IN
cord-300194-nsp53lv6	120	18	opposite	opposite	JJ
cord-300194-nsp53lv6	120	19	direction	direction	NN
cord-300194-nsp53lv6	120	20	.	.	.
cord-300194-nsp53lv6	121	1	The	the	DT
cord-300194-nsp53lv6	121	2	upper	upper	JJ
cord-300194-nsp53lv6	121	3	layer	layer	NN
cord-300194-nsp53lv6	121	4	of	of	IN
cord-300194-nsp53lv6	121	5	the	the	DT
cord-300194-nsp53lv6	121	6	beta	beta	NN
cord-300194-nsp53lv6	121	7	sandwich	sandwich	NN
cord-300194-nsp53lv6	121	8	is	be	VBZ
cord-300194-nsp53lv6	121	9	composed	compose	VBN
cord-300194-nsp53lv6	121	10	of	of	IN
cord-300194-nsp53lv6	121	11	beta	beta	NN
cord-300194-nsp53lv6	121	12	strands	strand	NNS
cord-300194-nsp53lv6	121	13	β	β	NNP
cord-300194-nsp53lv6	121	14	β	β	NN
cord-300194-nsp53lv6	121	15	β	β	NN
cord-300194-nsp53lv6	121	16	β	β	NN
cord-300194-nsp53lv6	122	1	β	β	XX
cord-300194-nsp53lv6	122	2	β1	β1	NNP
cord-300194-nsp53lv6	122	3	β1	β1	NNP
cord-300194-nsp53lv6	122	4	igure	igure	NN
cord-300194-nsp53lv6	122	5	S	s	NN
cord-300194-nsp53lv6	123	1	The	the	DT
cord-300194-nsp53lv6	123	2	three	three	CD
cord-300194-nsp53lv6	123	3	prominent	prominent	JJ
cord-300194-nsp53lv6	123	4	regions	region	NNS
cord-300194-nsp53lv6	123	5	which	which	WDT
cord-300194-nsp53lv6	123	6	are	be	VBP
cord-300194-nsp53lv6	123	7	exposed	expose	VBN
cord-300194-nsp53lv6	123	8	to	to	IN
cord-300194-nsp53lv6	123	9	the	the	DT
cord-300194-nsp53lv6	123	10	solvent	solvent	NN
cord-300194-nsp53lv6	123	11	and	and	CC
cord-300194-nsp53lv6	123	12	capable	capable	JJ
cord-300194-nsp53lv6	123	13	of	of	IN
cord-300194-nsp53lv6	123	14	interacting	interact	VBG
cord-300194-nsp53lv6	123	15	with	with	IN
cord-300194-nsp53lv6	123	16	potential	potential	JJ
cord-300194-nsp53lv6	123	17	receptors	receptor	NNS
cord-300194-nsp53lv6	123	18	are	be	VBP
cord-300194-nsp53lv6	123	19	regions	region	NNS
cord-300194-nsp53lv6	123	20	N	n	CD
cord-300194-nsp53lv6	123	21	-	-	HYPH
cord-300194-nsp53lv6	123	22	terminal	terminal	NN
cord-300194-nsp53lv6	123	23	β	β	NNP
cord-300194-nsp53lv6	123	24	strand	strand	NN
cord-300194-nsp53lv6	123	25	ββ	ββ	NNP
cord-300194-nsp53lv6	123	26	β	β	NNP
cord-300194-nsp53lv6	123	27	-β1	-β1	NNP
cord-300194-nsp53lv6	123	28	and	and	CC
cord-300194-nsp53lv6	123	29	β1	β1	NNP
cord-300194-nsp53lv6	123	30	-β15	-β15	NNP
cord-300194-nsp53lv6	123	31	loop	loop	NN
cord-300194-nsp53lv6	123	32	.	.	.
cord-300194-nsp53lv6	124	1	Comparison	comparison	NN
cord-300194-nsp53lv6	124	2	of	of	IN
cord-300194-nsp53lv6	124	3	the	the	DT
cord-300194-nsp53lv6	124	4	NTD	NTD	NNP
cord-300194-nsp53lv6	124	5	at	at	IN
cord-300194-nsp53lv6	124	6	different	different	JJ
cord-300194-nsp53lv6	124	7	temperatures	temperature	NNS
cord-300194-nsp53lv6	124	8	(	(	-LRB-
cord-300194-nsp53lv6	124	9	Figure	figure	NN
cord-300194-nsp53lv6	124	10	5	5	CD
cord-300194-nsp53lv6	124	11	)	)	-RRB-
cord-300194-nsp53lv6	124	12	show	show	VBP
cord-300194-nsp53lv6	124	13	differential	differential	NN
cord-300194-nsp53lv6	124	14	arrangement	arrangement	NN
cord-300194-nsp53lv6	124	15	of	of	IN
cord-300194-nsp53lv6	124	16	the	the	DT
cord-300194-nsp53lv6	124	17	solvent	solvent	NN
cord-300194-nsp53lv6	124	18	exposed	expose	VBD
cord-300194-nsp53lv6	124	19	loops	loop	NNS
cord-300194-nsp53lv6	124	20	.	.	.
cord-300194-nsp53lv6	125	1	The	the	DT
cord-300194-nsp53lv6	125	2	loops	loop	NNS
cord-300194-nsp53lv6	125	3	are	be	VBP
cord-300194-nsp53lv6	125	4	formed	form	VBN
cord-300194-nsp53lv6	125	5	by	by	IN
cord-300194-nsp53lv6	125	6	residues	residue	NNS
cord-300194-nsp53lv6	125	7	from	from	IN
cord-300194-nsp53lv6	125	8	N	n	CD
cord-300194-nsp53lv6	125	9	-	-	HYPH
cord-300194-nsp53lv6	125	10	terminal	terminal	NN
cord-300194-nsp53lv6	125	11	β	β	NNP
cord-300194-nsp53lv6	125	12	strand	strand	NN
cord-300194-nsp53lv6	125	13	ββ	ββ	NNP
cord-300194-nsp53lv6	125	14	β	β	NNP
cord-300194-nsp53lv6	125	15	-β1	-β1	NNP
cord-300194-nsp53lv6	125	16	and	and	CC
cord-300194-nsp53lv6	125	17	β1	β1	NNP
cord-300194-nsp53lv6	125	18	-β1	-β1	NNP
cord-300194-nsp53lv6	125	19	.	.	.
cord-300194-nsp53lv6	126	1	The	the	DT
cord-300194-nsp53lv6	126	2	time	time	NN
cord-300194-nsp53lv6	126	3	averaged	average	VBD
cord-300194-nsp53lv6	126	4	conformation	conformation	NN
cord-300194-nsp53lv6	126	5	of	of	IN
cord-300194-nsp53lv6	126	6	the	the	DT
cord-300194-nsp53lv6	126	7	loops	loop	NNS
cord-300194-nsp53lv6	126	8	after	after	IN
cord-300194-nsp53lv6	126	9	200ns	200ns	NNP
cord-300194-nsp53lv6	126	10	of	of	IN
cord-300194-nsp53lv6	126	11	simulation	simulation	NN
cord-300194-nsp53lv6	126	12	show	show	VBP
cord-300194-nsp53lv6	126	13	that	that	IN
cord-300194-nsp53lv6	126	14	the	the	DT
cord-300194-nsp53lv6	126	15	loops	loop	NNS
cord-300194-nsp53lv6	126	16	are	be	VBP
cord-300194-nsp53lv6	126	17	oriented	orient	VBN
cord-300194-nsp53lv6	126	18	close	close	RB
cord-300194-nsp53lv6	126	19	to	to	IN
cord-300194-nsp53lv6	126	20	each	each	DT
cord-300194-nsp53lv6	126	21	other	other	JJ
cord-300194-nsp53lv6	126	22	at	at	IN
cord-300194-nsp53lv6	126	23	temperatures	temperature	NNS
cord-300194-nsp53lv6	126	24	10	10	CD
cord-300194-nsp53lv6	126	25	-	-	SYM
cord-300194-nsp53lv6	126	26	30	30	CD
cord-300194-nsp53lv6	126	27	C	c	NN
cord-300194-nsp53lv6	126	28	,	,	,
cord-300194-nsp53lv6	126	29	however	however	RB
cord-300194-nsp53lv6	126	30	at	at	IN
cord-300194-nsp53lv6	126	31	40	40	CD
cord-300194-nsp53lv6	126	32	C	c	NN
cord-300194-nsp53lv6	126	33	and	and	CC
cord-300194-nsp53lv6	126	34	50	50	CD
cord-300194-nsp53lv6	126	35	C	c	NN
cord-300194-nsp53lv6	126	36	,	,	,
cord-300194-nsp53lv6	126	37	they	-PRON-	PRP
cord-300194-nsp53lv6	126	38	move	move	VBP
cord-300194-nsp53lv6	126	39	farther	farther	RB
cord-300194-nsp53lv6	126	40	away	away	RB
cord-300194-nsp53lv6	126	41	from	from	IN
cord-300194-nsp53lv6	126	42	each	each	DT
cord-300194-nsp53lv6	126	43	other	other	JJ
cord-300194-nsp53lv6	126	44	.	.	.
cord-300194-nsp53lv6	127	1	Since	since	IN
cord-300194-nsp53lv6	127	2	,	,	,
cord-300194-nsp53lv6	127	3	there	there	EX
cord-300194-nsp53lv6	127	4	was	be	VBD
cord-300194-nsp53lv6	127	5	similarity	similarity	NN
cord-300194-nsp53lv6	127	6	between	between	IN
cord-300194-nsp53lv6	127	7	the	the	DT
cord-300194-nsp53lv6	127	8	Ehprin	Ehprin	NNP
cord-300194-nsp53lv6	127	9	A	A	NNP
cord-300194-nsp53lv6	127	10	proteins	protein	NNS
cord-300194-nsp53lv6	127	11	that	that	WDT
cord-300194-nsp53lv6	127	12	binds	bind	VBZ
cord-300194-nsp53lv6	127	13	to	to	IN
cord-300194-nsp53lv6	127	14	the	the	DT
cord-300194-nsp53lv6	127	15	Ephrin	Ephrin	NNP
cord-300194-nsp53lv6	127	16	A	A	NNP
cord-300194-nsp53lv6	127	17	receptors	receptor	NNS
cord-300194-nsp53lv6	127	18	;	;	:
cord-300194-nsp53lv6	127	19	we	-PRON-	PRP
cord-300194-nsp53lv6	127	20	compared	compare	VBD
cord-300194-nsp53lv6	127	21	the	the	DT
cord-300194-nsp53lv6	127	22	residues	residue	NNS
cord-300194-nsp53lv6	127	23	involved	involve	VBN
cord-300194-nsp53lv6	127	24	in	in	IN
cord-300194-nsp53lv6	127	25	protein-	protein-	JJ
cord-300194-nsp53lv6	127	26	13	13	CD
cord-300194-nsp53lv6	127	27	protein	protein	NN
cord-300194-nsp53lv6	127	28	interaction	interaction	NN
cord-300194-nsp53lv6	127	29	in	in	IN
cord-300194-nsp53lv6	127	30	the	the	DT
cord-300194-nsp53lv6	127	31	crystal	crystal	JJ
cord-300194-nsp53lv6	127	32	structure	structure	NN
cord-300194-nsp53lv6	127	33	of	of	IN
cord-300194-nsp53lv6	127	34	the	the	DT
cord-300194-nsp53lv6	127	35	human	human	JJ
cord-300194-nsp53lv6	127	36	EphA4	EphA4	NNP
cord-300194-nsp53lv6	127	37	ectodomain	ectodomain	NN
cord-300194-nsp53lv6	127	38	in	in	IN
cord-300194-nsp53lv6	127	39	complex	complex	NN
cord-300194-nsp53lv6	127	40	with	with	IN
cord-300194-nsp53lv6	127	41	human	human	JJ
cord-300194-nsp53lv6	127	42	Ephrin	Ephrin	NNP
cord-300194-nsp53lv6	127	43	A5	A5	NNP
cord-300194-nsp53lv6	127	44	for	for	IN
cord-300194-nsp53lv6	127	45	comparison	comparison	NN
cord-300194-nsp53lv6	127	46	.	.	.
cord-300194-nsp53lv6	128	1	(	(	-LRB-
cord-300194-nsp53lv6	128	2	PDB	PDB	NNP
cord-300194-nsp53lv6	128	3	ID	ID	NNP
cord-300194-nsp53lv6	128	4	:	:	:
cord-300194-nsp53lv6	128	5	4BKA	4bka	CD
cord-300194-nsp53lv6	128	6	)	)	-RRB-
cord-300194-nsp53lv6	128	7	.	.	.
cord-300194-nsp53lv6	129	1	There	there	EX
cord-300194-nsp53lv6	129	2	are	be	VBP
cord-300194-nsp53lv6	129	3	three	three	CD
cord-300194-nsp53lv6	129	4	salt	salt	NN
cord-300194-nsp53lv6	129	5	bridges	bridge	NNS
cord-300194-nsp53lv6	129	6	and	and	CC
cord-300194-nsp53lv6	129	7	seven	seven	CD
cord-300194-nsp53lv6	129	8	hydrogen	hydrogen	NN
cord-300194-nsp53lv6	129	9	bonds	bond	NNS
cord-300194-nsp53lv6	129	10	between	between	IN
cord-300194-nsp53lv6	129	11	the	the	DT
cord-300194-nsp53lv6	129	12	Ephrin	Ephrin	NNP
cord-300194-nsp53lv6	129	13	protein	protein	NN
cord-300194-nsp53lv6	129	14	and	and	CC
cord-300194-nsp53lv6	129	15	its	-PRON-	PRP$
cord-300194-nsp53lv6	129	16	receptor	receptor	NN
cord-300194-nsp53lv6	129	17	.	.	.
cord-300194-nsp53lv6	130	1	Moreover	moreover	RB
cord-300194-nsp53lv6	130	2	,	,	,
cord-300194-nsp53lv6	130	3	it	-PRON-	PRP
cord-300194-nsp53lv6	130	4	can	can	MD
cord-300194-nsp53lv6	130	5	be	be	VB
cord-300194-nsp53lv6	130	6	clearly	clearly	RB
cord-300194-nsp53lv6	130	7	seen	see	VBN
cord-300194-nsp53lv6	130	8	that	that	IN
cord-300194-nsp53lv6	130	9	the	the	DT
cord-300194-nsp53lv6	130	10	NTD	NTD	NNP
cord-300194-nsp53lv6	130	11	loops	loop	NNS
cord-300194-nsp53lv6	130	12	host	host	VBP
cord-300194-nsp53lv6	130	13	a	a	DT
cord-300194-nsp53lv6	130	14	large	large	JJ
cord-300194-nsp53lv6	130	15	number	number	NN
cord-300194-nsp53lv6	130	16	of	of	IN
cord-300194-nsp53lv6	130	17	polar	polar	JJ
cord-300194-nsp53lv6	130	18	residues	residue	NNS
cord-300194-nsp53lv6	130	19	(	(	-LRB-
cord-300194-nsp53lv6	130	20	Figure	figure	NN
cord-300194-nsp53lv6	130	21	5	5	CD
cord-300194-nsp53lv6	130	22	)	)	-RRB-
cord-300194-nsp53lv6	130	23	.	.	.
cord-300194-nsp53lv6	131	1	These	these	DT
cord-300194-nsp53lv6	131	2	residues	residue	NNS
cord-300194-nsp53lv6	131	3	form	form	VBP
cord-300194-nsp53lv6	131	4	a	a	DT
cord-300194-nsp53lv6	131	5	stable	stable	JJ
cord-300194-nsp53lv6	131	6	motif	motif	NN
cord-300194-nsp53lv6	131	7	at	at	IN
cord-300194-nsp53lv6	131	8	temperatures	temperature	NNS
cord-300194-nsp53lv6	131	9	10	10	CD
cord-300194-nsp53lv6	131	10	-	-	SYM
cord-300194-nsp53lv6	131	11	30	30	CD
cord-300194-nsp53lv6	131	12	C	c	NN
cord-300194-nsp53lv6	131	13	,	,	,
cord-300194-nsp53lv6	131	14	primarily	primarily	RB
cord-300194-nsp53lv6	131	15	due	due	IN
cord-300194-nsp53lv6	131	16	to	to	IN
cord-300194-nsp53lv6	131	17	the	the	DT
cord-300194-nsp53lv6	131	18	stability	stability	NN
cord-300194-nsp53lv6	131	19	between	between	IN
cord-300194-nsp53lv6	131	20	the	the	DT
cord-300194-nsp53lv6	131	21	loops	loop	NNS
cord-300194-nsp53lv6	131	22	.	.	.
cord-300194-nsp53lv6	132	1	At	at	IN
cord-300194-nsp53lv6	132	2	40	40	CD
cord-300194-nsp53lv6	132	3	C	c	NN
cord-300194-nsp53lv6	132	4	and	and	CC
cord-300194-nsp53lv6	132	5	50	50	CD
cord-300194-nsp53lv6	132	6	C	c	NN
cord-300194-nsp53lv6	132	7	,	,	,
cord-300194-nsp53lv6	132	8	hydrophobic	hydrophobic	JJ
cord-300194-nsp53lv6	132	9	patch	patch	NN
cord-300194-nsp53lv6	132	10	from	from	IN
cord-300194-nsp53lv6	132	11	N	n	CD
cord-300194-nsp53lv6	132	12	-	-	HYPH
cord-300194-nsp53lv6	132	13	terminal	terminal	NN
cord-300194-nsp53lv6	132	14	β	β	NNP
cord-300194-nsp53lv6	132	15	strand	strand	NN
cord-300194-nsp53lv6	132	16	is	be	VBZ
cord-300194-nsp53lv6	132	17	exposed	expose	VBN
cord-300194-nsp53lv6	132	18	towards	towards	IN
cord-300194-nsp53lv6	132	19	the	the	DT
cord-300194-nsp53lv6	132	20	solvent	solvent	NN
cord-300194-nsp53lv6	132	21	.	.	.
cord-300194-nsp53lv6	133	1	The	the	DT
cord-300194-nsp53lv6	133	2	polar	polar	JJ
cord-300194-nsp53lv6	133	3	residues	residue	NNS
cord-300194-nsp53lv6	133	4	from	from	IN
cord-300194-nsp53lv6	133	5	β	β	NNP
cord-300194-nsp53lv6	133	6	-β1	-β1	NNP
cord-300194-nsp53lv6	133	7	and	and	CC
cord-300194-nsp53lv6	133	8	β1	β1	NNP
cord-300194-nsp53lv6	133	9	-β1	-β1	NNP
cord-300194-nsp53lv6	133	10	move	move	VBP
cord-300194-nsp53lv6	133	11	away	away	RB
cord-300194-nsp53lv6	133	12	from	from	IN
cord-300194-nsp53lv6	133	13	the	the	DT
cord-300194-nsp53lv6	133	14	N	N	NNP
cord-300194-nsp53lv6	133	15	-	-	HYPH
cord-300194-nsp53lv6	133	16	terminal	terminal	NN
cord-300194-nsp53lv6	133	17	β	β	NNP
cord-300194-nsp53lv6	133	18	strand	strand	NN
cord-300194-nsp53lv6	133	19	and	and	CC
cord-300194-nsp53lv6	133	20	the	the	DT
cord-300194-nsp53lv6	133	21	β	β	NN
cord-300194-nsp53lv6	133	22	-β	-β	NN
cord-300194-nsp53lv6	133	23	loop	loop	NNP
cord-300194-nsp53lv6	133	24	,	,	,
cord-300194-nsp53lv6	133	25	reducing	reduce	VBG
cord-300194-nsp53lv6	133	26	the	the	DT
cord-300194-nsp53lv6	133	27	possibility	possibility	NN
cord-300194-nsp53lv6	133	28	of	of	IN
cord-300194-nsp53lv6	133	29	protein	protein	NN
cord-300194-nsp53lv6	133	30	-	-	HYPH
cord-300194-nsp53lv6	133	31	protein	protein	NN
cord-300194-nsp53lv6	133	32	interaction	interaction	NN
cord-300194-nsp53lv6	133	33	.	.	.
cord-300194-nsp53lv6	134	1	Hence	hence	RB
cord-300194-nsp53lv6	134	2	,	,	,
cord-300194-nsp53lv6	134	3	a	a	DT
cord-300194-nsp53lv6	134	4	strong	strong	JJ
cord-300194-nsp53lv6	134	5	possibility	possibility	NN
cord-300194-nsp53lv6	134	6	exists	exist	VBZ
cord-300194-nsp53lv6	134	7	for	for	IN
cord-300194-nsp53lv6	134	8	the	the	DT
cord-300194-nsp53lv6	134	9	NTD	NTD	NNP
cord-300194-nsp53lv6	134	10	to	to	TO
cord-300194-nsp53lv6	134	11	act	act	VB
cord-300194-nsp53lv6	134	12	as	as	IN
cord-300194-nsp53lv6	134	13	a	a	DT
cord-300194-nsp53lv6	134	14	protein	protein	NN
cord-300194-nsp53lv6	134	15	binding	binding	NN
cord-300194-nsp53lv6	134	16	site	site	NN
cord-300194-nsp53lv6	134	17	at	at	IN
cord-300194-nsp53lv6	134	18	lower	low	JJR
cord-300194-nsp53lv6	134	19	temperature	temperature	NN
cord-300194-nsp53lv6	134	20	ranges	range	NNS
cord-300194-nsp53lv6	134	21	.	.	.
cord-300194-nsp53lv6	135	1	From	from	IN
cord-300194-nsp53lv6	135	2	the	the	DT
cord-300194-nsp53lv6	135	3	bioinformatics	bioinformatic	NNS
cord-300194-nsp53lv6	135	4	and	and	CC
cord-300194-nsp53lv6	135	5	structural	structural	JJ
cord-300194-nsp53lv6	135	6	analyses	analysis	NNS
cord-300194-nsp53lv6	135	7	,	,	,
cord-300194-nsp53lv6	135	8	we	-PRON-	PRP
cord-300194-nsp53lv6	135	9	observed	observe	VBD
cord-300194-nsp53lv6	135	10	that	that	IN
cord-300194-nsp53lv6	135	11	the	the	DT
cord-300194-nsp53lv6	135	12	NTD	NTD	NNP
cord-300194-nsp53lv6	135	13	not	not	RB
cord-300194-nsp53lv6	135	14	only	only	RB
cord-300194-nsp53lv6	135	15	acts	act	VBZ
cord-300194-nsp53lv6	135	16	as	as	IN
cord-300194-nsp53lv6	135	17	a	a	DT
cord-300194-nsp53lv6	135	18	glycan	glycan	NN
cord-300194-nsp53lv6	135	19	binding	bind	VBG
cord-300194-nsp53lv6	135	20	site	site	NN
cord-300194-nsp53lv6	135	21	but	but	CC
cord-300194-nsp53lv6	135	22	can	can	MD
cord-300194-nsp53lv6	135	23	also	also	RB
cord-300194-nsp53lv6	135	24	as	as	IN
cord-300194-nsp53lv6	135	25	a	a	DT
cord-300194-nsp53lv6	135	26	site	site	NN
cord-300194-nsp53lv6	135	27	for	for	IN
cord-300194-nsp53lv6	135	28	binding	bind	VBG
cord-300194-nsp53lv6	135	29	of	of	IN
cord-300194-nsp53lv6	135	30	several	several	JJ
cord-300194-nsp53lv6	135	31	human	human	JJ
cord-300194-nsp53lv6	135	32	proteins	protein	NNS
cord-300194-nsp53lv6	135	33	.	.	.
cord-300194-nsp53lv6	136	1	The	the	DT
cord-300194-nsp53lv6	136	2	motif	motif	NN
cord-300194-nsp53lv6	136	3	formed	form	VBN
cord-300194-nsp53lv6	136	4	out	out	IN
cord-300194-nsp53lv6	136	5	of	of	IN
cord-300194-nsp53lv6	136	6	several	several	JJ
cord-300194-nsp53lv6	136	7	polar	polar	JJ
cord-300194-nsp53lv6	136	8	residues	residue	NNS
cord-300194-nsp53lv6	136	9	on	on	IN
cord-300194-nsp53lv6	136	10	the	the	DT
cord-300194-nsp53lv6	136	11	solvent	solvent	NN
cord-300194-nsp53lv6	136	12	exposed	expose	VBD
cord-300194-nsp53lv6	136	13	loops	loop	NNS
cord-300194-nsp53lv6	136	14	at	at	IN
cord-300194-nsp53lv6	136	15	1	1	CD
cord-300194-nsp53lv6	136	16	-ould	-ould	HYPH
cord-300194-nsp53lv6	136	17	form	form	NN
cord-300194-nsp53lv6	136	18	salt	salt	NN
cord-300194-nsp53lv6	136	19	-	-	HYPH
cord-300194-nsp53lv6	136	20	bridges	bridge	NNS
cord-300194-nsp53lv6	136	21	and	and	CC
cord-300194-nsp53lv6	136	22	hydrogen	hydrogen	NN
cord-300194-nsp53lv6	136	23	bonds	bond	NNS
cord-300194-nsp53lv6	136	24	with	with	IN
cord-300194-nsp53lv6	136	25	partner	partner	NN
cord-300194-nsp53lv6	136	26	proteins	protein	NNS
cord-300194-nsp53lv6	136	27	.	.	.
cord-300194-nsp53lv6	137	1	At	at	IN
cord-300194-nsp53lv6	137	2	higher	high	JJR
cord-300194-nsp53lv6	137	3	temperatures	temperature	NNS
cord-300194-nsp53lv6	137	4	,	,	,
cord-300194-nsp53lv6	137	5	the	the	DT
cord-300194-nsp53lv6	137	6	propensity	propensity	NN
cord-300194-nsp53lv6	137	7	of	of	IN
cord-300194-nsp53lv6	137	8	forming	form	VBG
cord-300194-nsp53lv6	137	9	such	such	JJ
cord-300194-nsp53lv6	137	10	interactions	interaction	NNS
cord-300194-nsp53lv6	137	11	would	would	MD
cord-300194-nsp53lv6	137	12	be	be	VB
cord-300194-nsp53lv6	137	13	lost	lose	VBN
cord-300194-nsp53lv6	137	14	owing	owe	VBG
cord-300194-nsp53lv6	137	15	to	to	IN
cord-300194-nsp53lv6	137	16	the	the	DT
cord-300194-nsp53lv6	137	17	differential	differential	JJ
cord-300194-nsp53lv6	137	18	orientation	orientation	NN
cord-300194-nsp53lv6	137	19	of	of	IN
cord-300194-nsp53lv6	137	20	the	the	DT
cord-300194-nsp53lv6	137	21	loops	loop	NNS
cord-300194-nsp53lv6	137	22	.	.	.
cord-300194-nsp53lv6	138	1	Nonetheless	nonetheless	RB
cord-300194-nsp53lv6	138	2	,	,	,
cord-300194-nsp53lv6	138	3	the	the	DT
cord-300194-nsp53lv6	138	4	NTD	NTD	NNP
cord-300194-nsp53lv6	138	5	could	could	MD
cord-300194-nsp53lv6	138	6	act	act	VB
cord-300194-nsp53lv6	138	7	as	as	IN
cord-300194-nsp53lv6	138	8	a	a	DT
cord-300194-nsp53lv6	138	9	possible	possible	JJ
cord-300194-nsp53lv6	138	10	target	target	NN
cord-300194-nsp53lv6	138	11	for	for	IN
cord-300194-nsp53lv6	138	12	development	development	NN
cord-300194-nsp53lv6	138	13	of	of	IN
cord-300194-nsp53lv6	138	14	vaccines	vaccine	NNS
cord-300194-nsp53lv6	138	15	and	and	CC
cord-300194-nsp53lv6	138	16	inhibitors	inhibitor	NNS
cord-300194-nsp53lv6	138	17	.	.	.
cord-300194-nsp53lv6	139	1	The	the	DT
cord-300194-nsp53lv6	139	2	receptor	receptor	NN
cord-300194-nsp53lv6	139	3	binding	bind	VBG
cord-300194-nsp53lv6	139	4	domain	domain	NN
cord-300194-nsp53lv6	139	5	(	(	-LRB-
cord-300194-nsp53lv6	139	6	RBD	RBD	NNP
cord-300194-nsp53lv6	139	7	)	)	-RRB-
cord-300194-nsp53lv6	139	8	of	of	IN
cord-300194-nsp53lv6	139	9	the	the	DT
cord-300194-nsp53lv6	139	10	Spike	Spike	NNP
cord-300194-nsp53lv6	139	11	glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	139	12	is	be	VBZ
cord-300194-nsp53lv6	139	13	a	a	DT
cord-300194-nsp53lv6	139	14	potential	potential	JJ
cord-300194-nsp53lv6	139	15	target	target	NN
cord-300194-nsp53lv6	139	16	for	for	IN
cord-300194-nsp53lv6	139	17	vaccine	vaccine	NN
cord-300194-nsp53lv6	139	18	and	and	CC
cord-300194-nsp53lv6	139	19	drug	drug	NN
cord-300194-nsp53lv6	139	20	development	development	NN
cord-300194-nsp53lv6	139	21	[	[	-LRB-
cord-300194-nsp53lv6	139	22	36	36	CD
cord-300194-nsp53lv6	139	23	,	,	,
cord-300194-nsp53lv6	139	24	37	37	CD
cord-300194-nsp53lv6	139	25	]	]	-RRB-
cord-300194-nsp53lv6	139	26	.	.	.
cord-300194-nsp53lv6	140	1	It	-PRON-	PRP
cord-300194-nsp53lv6	140	2	is	be	VBZ
cord-300194-nsp53lv6	140	3	highly	highly	RB
cord-300194-nsp53lv6	140	4	conserved	conserve	VBN
cord-300194-nsp53lv6	140	5	among	among	IN
cord-300194-nsp53lv6	140	6	the	the	DT
cord-300194-nsp53lv6	140	7	human	human	JJ
cord-300194-nsp53lv6	140	8	coronaviruses	coronaviruse	NNS
cord-300194-nsp53lv6	140	9	and	and	CC
cord-300194-nsp53lv6	140	10	binds	bind	VBZ
cord-300194-nsp53lv6	140	11	to	to	IN
cord-300194-nsp53lv6	140	12	ACE2	ACE2	NNP
cord-300194-nsp53lv6	140	13	receptor	receptor	NN
cord-300194-nsp53lv6	140	14	present	present	NN
cord-300194-nsp53lv6	140	15	on	on	IN
cord-300194-nsp53lv6	140	16	the	the	DT
cord-300194-nsp53lv6	140	17	lung	lung	NN
cord-300194-nsp53lv6	140	18	tissues	tissue	NNS
cord-300194-nsp53lv6	140	19	[	[	-LRB-
cord-300194-nsp53lv6	140	20	38	38	CD
cord-300194-nsp53lv6	140	21	]	]	-RRB-
cord-300194-nsp53lv6	140	22	.	.	.
cord-300194-nsp53lv6	141	1	Residues	residue	NNS
cord-300194-nsp53lv6	141	2	458	458	CD
cord-300194-nsp53lv6	141	3	-	-	SYM
cord-300194-nsp53lv6	141	4	506	506	CD
cord-300194-nsp53lv6	141	5	of	of	IN
cord-300194-nsp53lv6	141	6	the	the	DT
cord-300194-nsp53lv6	141	7	RBD	RBD	NNP
cord-300194-nsp53lv6	141	8	domain	domain	NN
cord-300194-nsp53lv6	141	9	comprises	comprise	VBZ
cord-300194-nsp53lv6	141	10	of	of	IN
cord-300194-nsp53lv6	141	11	the	the	DT
cord-300194-nsp53lv6	141	12	receptor	receptor	NN
cord-300194-nsp53lv6	141	13	binding	bind	VBG
cord-300194-nsp53lv6	141	14	motif	motif	NN
cord-300194-nsp53lv6	141	15	(	(	-LRB-
cord-300194-nsp53lv6	141	16	RBM	RBM	NNP
cord-300194-nsp53lv6	141	17	)	)	-RRB-
cord-300194-nsp53lv6	141	18	.	.	.
cord-300194-nsp53lv6	142	1	The	the	DT
cord-300194-nsp53lv6	142	2	RBM	RBM	NNP
cord-300194-nsp53lv6	142	3	has	have	VBZ
cord-300194-nsp53lv6	142	4	8	8	CD
cord-300194-nsp53lv6	142	5	residues	residue	NNS
cord-300194-nsp53lv6	142	6	which	which	WDT
cord-300194-nsp53lv6	142	7	are	be	VBP
cord-300194-nsp53lv6	142	8	identical	identical	JJ
cord-300194-nsp53lv6	142	9	and	and	CC
cord-300194-nsp53lv6	142	10	14	14	CD
cord-300194-nsp53lv6	142	11	 	 	_SP
cord-300194-nsp53lv6	142	12	conserved	conserve	VBN
cord-300194-nsp53lv6	142	13	region	region	NN
cord-300194-nsp53lv6	142	14	primarily	primarily	RB
cord-300194-nsp53lv6	142	15	interacts	interact	VBZ
cord-300194-nsp53lv6	142	16	with	with	IN
cord-300194-nsp53lv6	142	17	the	the	DT
cord-300194-nsp53lv6	142	18	ACE2	ACE2	NNP
cord-300194-nsp53lv6	142	19	receptor	receptor	NN
cord-300194-nsp53lv6	142	20	and	and	CC
cord-300194-nsp53lv6	142	21	hence	hence	RB
cord-300194-nsp53lv6	142	22	,	,	,
cord-300194-nsp53lv6	142	23	often	often	RB
cord-300194-nsp53lv6	142	24	scientists	scientist	NNS
cord-300194-nsp53lv6	142	25	target	target	VBP
cord-300194-nsp53lv6	142	26	the	the	DT
cord-300194-nsp53lv6	142	27	RBD	RBD	NNP
cord-300194-nsp53lv6	142	28	domain	domain	NN
cord-300194-nsp53lv6	142	29	of	of	IN
cord-300194-nsp53lv6	142	30	for	for	IN
cord-300194-nsp53lv6	142	31	developing	develop	VBG
cord-300194-nsp53lv6	142	32	therapeutic	therapeutic	JJ
cord-300194-nsp53lv6	142	33	agents	agent	NNS
cord-300194-nsp53lv6	142	34	[	[	-LRB-
cord-300194-nsp53lv6	142	35	36	36	CD
cord-300194-nsp53lv6	142	36	,	,	,
cord-300194-nsp53lv6	142	37	37	37	CD
cord-300194-nsp53lv6	142	38	,	,	,
cord-300194-nsp53lv6	142	39	and	and	CC
cord-300194-nsp53lv6	142	40	39	39	CD
cord-300194-nsp53lv6	142	41	]	]	-RRB-
cord-300194-nsp53lv6	142	42	.	.	.
cord-300194-nsp53lv6	143	1	Earlier	early	RBR
cord-300194-nsp53lv6	143	2	in	in	IN
cord-300194-nsp53lv6	143	3	Figure	figure	NN
cord-300194-nsp53lv6	143	4	2	2	CD
cord-300194-nsp53lv6	143	5	,	,	,
cord-300194-nsp53lv6	143	6	we	-PRON-	PRP
cord-300194-nsp53lv6	143	7	saw	see	VBD
cord-300194-nsp53lv6	143	8	that	that	IN
cord-300194-nsp53lv6	143	9	the	the	DT
cord-300194-nsp53lv6	143	10	RBD	RBD	NNP
cord-300194-nsp53lv6	143	11	domain	domain	NN
cord-300194-nsp53lv6	143	12	spanning	span	VBG
cord-300194-nsp53lv6	143	13	from	from	IN
cord-300194-nsp53lv6	143	14	residues	residue	NNS
cord-300194-nsp53lv6	143	15	333	333	CD
cord-300194-nsp53lv6	143	16	-	-	SYM
cord-300194-nsp53lv6	143	17	680	680	CD
cord-300194-nsp53lv6	143	18	shows	show	VBZ
cord-300194-nsp53lv6	143	19	higher	high	JJR
cord-300194-nsp53lv6	143	20	stability	stability	NN
cord-300194-nsp53lv6	143	21	when	when	WRB
cord-300194-nsp53lv6	143	22	compared	compare	VBN
cord-300194-nsp53lv6	143	23	to	to	IN
cord-300194-nsp53lv6	143	24	the	the	DT
cord-300194-nsp53lv6	143	25	NTD	NTD	NNP
cord-300194-nsp53lv6	143	26	of	of	IN
cord-300194-nsp53lv6	143	27	the	the	DT
cord-300194-nsp53lv6	143	28	S1	S1	NNP
cord-300194-nsp53lv6	143	29	domain	domain	NN
cord-300194-nsp53lv6	143	30	at	at	IN
cord-300194-nsp53lv6	143	31	different	different	JJ
cord-300194-nsp53lv6	143	32	range	range	NN
cord-300194-nsp53lv6	143	33	of	of	IN
cord-300194-nsp53lv6	143	34	temperatures	temperature	NNS
cord-300194-nsp53lv6	143	35	.	.	.
cord-300194-nsp53lv6	144	1	We	-PRON-	PRP
cord-300194-nsp53lv6	144	2	compared	compare	VBD
cord-300194-nsp53lv6	144	3	the	the	DT
cord-300194-nsp53lv6	144	4	time	time	NN
cord-300194-nsp53lv6	144	5	averaged	average	VBD
cord-300194-nsp53lv6	144	6	conformation	conformation	NN
cord-300194-nsp53lv6	144	7	of	of	IN
cord-300194-nsp53lv6	144	8	the	the	DT
cord-300194-nsp53lv6	144	9	RBD	RBD	NNP
cord-300194-nsp53lv6	144	10	generated	generate	VBN
cord-300194-nsp53lv6	144	11	from	from	IN
cord-300194-nsp53lv6	144	12	the	the	DT
cord-300194-nsp53lv6	144	13	last	last	JJ
cord-300194-nsp53lv6	144	14	10ns	10ns	NN
cord-300194-nsp53lv6	144	15	of	of	IN
cord-300194-nsp53lv6	144	16	the	the	DT
cord-300194-nsp53lv6	144	17	simulation	simulation	NN
cord-300194-nsp53lv6	144	18	time	time	NN
cord-300194-nsp53lv6	144	19	at	at	IN
cord-300194-nsp53lv6	144	20	different	different	JJ
cord-300194-nsp53lv6	144	21	temperatures	temperature	NNS
cord-300194-nsp53lv6	144	22	igure	igure	JJ
cord-300194-nsp53lv6	145	1	The	the	DT
cord-300194-nsp53lv6	145	2	ore	ore	NN
cord-300194-nsp53lv6	145	3	β	β	FW
cord-300194-nsp53lv6	145	4	pleated	pleated	JJ
cord-300194-nsp53lv6	145	5	sheet	sheet	NN
cord-300194-nsp53lv6	145	6	was	be	VBD
cord-300194-nsp53lv6	145	7	very	very	RB
cord-300194-nsp53lv6	145	8	sta	sta	NNP
cord-300194-nsp53lv6	145	9	le	le	NNP
cord-300194-nsp53lv6	145	10	demonstrating	demonstrate	VBG
cord-300194-nsp53lv6	145	11	no	no	DT
cord-300194-nsp53lv6	145	12	lack	lack	NN
cord-300194-nsp53lv6	145	13	of	of	IN
cord-300194-nsp53lv6	145	14	secondary	secondary	JJ
cord-300194-nsp53lv6	145	15	structures	structure	NNS
cord-300194-nsp53lv6	145	16	at	at	IN
cord-300194-nsp53lv6	145	17	higher	high	JJR
cord-300194-nsp53lv6	145	18	temperatures	temperature	NNS
cord-300194-nsp53lv6	145	19	.	.	.
cord-300194-nsp53lv6	146	1	However	however	RB
cord-300194-nsp53lv6	146	2	,	,	,
cord-300194-nsp53lv6	146	3	the	the	DT
cord-300194-nsp53lv6	146	4	RBM	RBM	NNP
cord-300194-nsp53lv6	146	5	motif	motif	NN
cord-300194-nsp53lv6	146	6	(	(	-LRB-
cord-300194-nsp53lv6	146	7	highlighted	highlight	VBN
cord-300194-nsp53lv6	146	8	in	in	IN
cord-300194-nsp53lv6	146	9	magenta	magenta	NN
cord-300194-nsp53lv6	146	10	in	in	IN
cord-300194-nsp53lv6	146	11	Figure	figure	NN
cord-300194-nsp53lv6	146	12	6	6	CD
cord-300194-nsp53lv6	146	13	)	)	-RRB-
cord-300194-nsp53lv6	146	14	shows	show	VBZ
cord-300194-nsp53lv6	146	15	a	a	DT
cord-300194-nsp53lv6	146	16	very	very	RB
cord-300194-nsp53lv6	146	17	dynamic	dynamic	JJ
cord-300194-nsp53lv6	146	18	conformation	conformation	NN
cord-300194-nsp53lv6	146	19	across	across	IN
cord-300194-nsp53lv6	146	20	different	different	JJ
cord-300194-nsp53lv6	146	21	temperature	temperature	NN
cord-300194-nsp53lv6	147	1	ranges	range	NNS
cord-300194-nsp53lv6	148	1	The	the	DT
cord-300194-nsp53lv6	148	2	dynami	dynami	NN
cord-300194-nsp53lv6	148	3	s	s	NN
cord-300194-nsp53lv6	148	4	was	be	VBD
cord-300194-nsp53lv6	148	5	more	more	JJR
cord-300194-nsp53lv6	148	6	pronoun	pronoun	NN
cord-300194-nsp53lv6	148	7	ed	ed	NN
cord-300194-nsp53lv6	148	8	at	at	IN
cord-300194-nsp53lv6	148	9	1	1	CD
cord-300194-nsp53lv6	148	10	C	c	NN
cord-300194-nsp53lv6	148	11	C	c	NN
cord-300194-nsp53lv6	148	12	and	and	CC
cord-300194-nsp53lv6	148	13	C	C	NNP
cord-300194-nsp53lv6	148	14	whereas	whereas	IN
cord-300194-nsp53lv6	148	15	at	at	IN
cord-300194-nsp53lv6	148	16	C	C	NNP
cord-300194-nsp53lv6	148	17	and	and	CC
cord-300194-nsp53lv6	148	18	C	C	NNP
cord-300194-nsp53lv6	148	19	of	of	IN
cord-300194-nsp53lv6	148	20	temperature	temperature	NN
cord-300194-nsp53lv6	148	21	,	,	,
cord-300194-nsp53lv6	148	22	the	the	DT
cord-300194-nsp53lv6	148	23	RBM	RBM	NNP
cord-300194-nsp53lv6	148	24	had	have	VBD
cord-300194-nsp53lv6	148	25	a	a	DT
cord-300194-nsp53lv6	148	26	more	more	RBR
cord-300194-nsp53lv6	148	27	confined	confine	VBN
cord-300194-nsp53lv6	148	28	onformation	onformation	NN
cord-300194-nsp53lv6	149	1	The	the	DT
cord-300194-nsp53lv6	149	2	R	r	NN
cord-300194-nsp53lv6	149	3	flexi	flexi	NN
cord-300194-nsp53lv6	149	4	ility	ility	NN
cord-300194-nsp53lv6	149	5	was	be	VBD
cord-300194-nsp53lv6	149	6	more	more	RBR
cord-300194-nsp53lv6	149	7	apparent	apparent	JJ
cord-300194-nsp53lv6	149	8	at	at	IN
cord-300194-nsp53lv6	149	9	C	C	NNP
cord-300194-nsp53lv6	149	10	and	and	CC
cord-300194-nsp53lv6	149	11	C	C	NNP
cord-300194-nsp53lv6	149	12	where	where	WRB
cord-300194-nsp53lv6	149	13	the	the	DT
cord-300194-nsp53lv6	149	14	three	three	CD
cord-300194-nsp53lv6	149	15	chains	chain	NNS
cord-300194-nsp53lv6	149	16	moved	move	VBD
cord-300194-nsp53lv6	149	17	further	further	RB
cord-300194-nsp53lv6	149	18	away	away	RB
cord-300194-nsp53lv6	149	19	from	from	IN
cord-300194-nsp53lv6	149	20	each	each	DT
cord-300194-nsp53lv6	149	21	other	other	JJ
cord-300194-nsp53lv6	149	22	.	.	.
cord-300194-nsp53lv6	150	1	However	however	RB
cord-300194-nsp53lv6	150	2	,	,	,
cord-300194-nsp53lv6	150	3	a	a	DT
cord-300194-nsp53lv6	150	4	tighter	tight	JJR
cord-300194-nsp53lv6	150	5	and	and	CC
cord-300194-nsp53lv6	150	6	well	well	RB
cord-300194-nsp53lv6	150	7	packed	packed	JJ
cord-300194-nsp53lv6	150	8	structure	structure	NN
cord-300194-nsp53lv6	150	9	was	be	VBD
cord-300194-nsp53lv6	150	10	found	find	VBN
cord-300194-nsp53lv6	150	11	for	for	IN
cord-300194-nsp53lv6	150	12	the	the	DT
cord-300194-nsp53lv6	150	13	protein	protein	NN
cord-300194-nsp53lv6	150	14	at	at	IN
cord-300194-nsp53lv6	150	15	50	50	CD
cord-300194-nsp53lv6	150	16	C.	c.	NN
cord-300194-nsp53lv6	151	1	The	the	DT
cord-300194-nsp53lv6	151	2	figures	figure	NNS
cord-300194-nsp53lv6	151	3	suggest	suggest	VBP
cord-300194-nsp53lv6	151	4	that	that	IN
cord-300194-nsp53lv6	151	5	although	although	IN
cord-300194-nsp53lv6	151	6	residue	residue	JJ
cord-300194-nsp53lv6	151	7	wise	wise	JJ
cord-300194-nsp53lv6	151	8	movements	movement	NNS
cord-300194-nsp53lv6	151	9	in	in	IN
cord-300194-nsp53lv6	151	10	RBD	RBD	NNP
cord-300194-nsp53lv6	151	11	were	be	VBD
cord-300194-nsp53lv6	151	12	not	not	RB
cord-300194-nsp53lv6	151	13	visible	visible	JJ
cord-300194-nsp53lv6	151	14	in	in	IN
cord-300194-nsp53lv6	151	15	RMSF	RMSF	NNP
cord-300194-nsp53lv6	151	16	(	(	-LRB-
cord-300194-nsp53lv6	151	17	Figure	figure	NN
cord-300194-nsp53lv6	151	18	2	2	CD
cord-300194-nsp53lv6	151	19	)	)	-RRB-
cord-300194-nsp53lv6	151	20	,	,	,
cord-300194-nsp53lv6	151	21	the	the	DT
cord-300194-nsp53lv6	151	22	RBD	RBD	NNP
cord-300194-nsp53lv6	151	23	domains	domain	NNS
cord-300194-nsp53lv6	151	24	and	and	CC
cord-300194-nsp53lv6	151	25	motifs	motif	NNS
cord-300194-nsp53lv6	151	26	show	show	VBP
cord-300194-nsp53lv6	151	27	intrinsic	intrinsic	JJ
cord-300194-nsp53lv6	151	28	flexibility	flexibility	NN
cord-300194-nsp53lv6	151	29	along	along	IN
cord-300194-nsp53lv6	151	30	particular	particular	JJ
cord-300194-nsp53lv6	151	31	temperature	temperature	NN
cord-300194-nsp53lv6	151	32	ranges	range	NNS
cord-300194-nsp53lv6	151	33	.	.	.
cord-300194-nsp53lv6	152	1	Previous	previous	JJ
cord-300194-nsp53lv6	152	2	studies	study	NNS
cord-300194-nsp53lv6	152	3	have	have	VBP
cord-300194-nsp53lv6	152	4	indicated	indicate	VBN
cord-300194-nsp53lv6	152	5	that	that	IN
cord-300194-nsp53lv6	152	6	the	the	DT
cord-300194-nsp53lv6	152	7	RBD	RBD	NNP
cord-300194-nsp53lv6	152	8	domain	domain	NN
cord-300194-nsp53lv6	152	9	can	can	MD
cord-300194-nsp53lv6	152	10	adopt	adopt	VB
cord-300194-nsp53lv6	152	11	either	either	CC
cord-300194-nsp53lv6	152	12	an	an	DT
cord-300194-nsp53lv6	152	13	open	open	JJ
cord-300194-nsp53lv6	152	14	or	or	CC
cord-300194-nsp53lv6	152	15	a	a	DT
cord-300194-nsp53lv6	152	16	closed	closed	JJ
cord-300194-nsp53lv6	152	17	conformation	conformation	NN
cord-300194-nsp53lv6	152	18	in	in	IN
cord-300194-nsp53lv6	152	19	the	the	DT
cord-300194-nsp53lv6	152	20	virus	virus	NN
cord-300194-nsp53lv6	152	21	[	[	-LRB-
cord-300194-nsp53lv6	152	22	18	18	CD
cord-300194-nsp53lv6	152	23	]	]	-RRB-
cord-300194-nsp53lv6	152	24	.	.	.
cord-300194-nsp53lv6	153	1	We	-PRON-	PRP
cord-300194-nsp53lv6	153	2	compared	compare	VBD
cord-300194-nsp53lv6	153	3	the	the	DT
cord-300194-nsp53lv6	153	4	conformation	conformation	NN
cord-300194-nsp53lv6	153	5	of	of	IN
cord-300194-nsp53lv6	153	6	the	the	DT
cord-300194-nsp53lv6	153	7	Spikeprotein	Spikeprotein	NNP
cord-300194-nsp53lv6	153	8	-	-	HYPH
cord-300194-nsp53lv6	153	9	ACE2	ACE2	NNP
cord-300194-nsp53lv6	153	10	crystal	crystal	NN
cord-300194-nsp53lv6	153	11	structure	structure	NN
cord-300194-nsp53lv6	153	12	and	and	CC
cord-300194-nsp53lv6	153	13	found	find	VBD
cord-300194-nsp53lv6	153	14	that	that	IN
cord-300194-nsp53lv6	153	15	in	in	IN
cord-300194-nsp53lv6	153	16	the	the	DT
cord-300194-nsp53lv6	153	17	open	open	JJ
cord-300194-nsp53lv6	153	18	conformation	conformation	NN
cord-300194-nsp53lv6	153	19	,	,	,
cord-300194-nsp53lv6	153	20	the	the	DT
cord-300194-nsp53lv6	153	21	RBD	RBD	NNP
cord-300194-nsp53lv6	153	22	exposes	expose	VBZ
cord-300194-nsp53lv6	153	23	its	-PRON-	PRP$
cord-300194-nsp53lv6	153	24	RBM	RBM	NNP
cord-300194-nsp53lv6	153	25	residues	residue	NNS
cord-300194-nsp53lv6	153	26	Phe456	phe456	IN
cord-300194-nsp53lv6	153	27	,	,	,
cord-300194-nsp53lv6	153	28	Ala475	ala475	UH
cord-300194-nsp53lv6	153	29	,	,	,
cord-300194-nsp53lv6	153	30	Phe486	phe486	ADD
cord-300194-nsp53lv6	153	31	,	,	,
cord-300194-nsp53lv6	153	32	Asn487	asn487	UH
cord-300194-nsp53lv6	153	33	,	,	,
cord-300194-nsp53lv6	153	34	Tyr489	tyr489	CD
cord-300194-nsp53lv6	153	35	,	,	,
cord-300194-nsp53lv6	153	36	Gln493	Gln493	NNP
cord-300194-nsp53lv6	153	37	,	,	,
cord-300194-nsp53lv6	153	38	Gly496	Gly496	NNP
cord-300194-nsp53lv6	153	39	,	,	,
cord-300194-nsp53lv6	153	40	Gln498	gln498	CD
cord-300194-nsp53lv6	153	41	,	,	,
cord-300194-nsp53lv6	153	42	Thr500	thr500	UH
cord-300194-nsp53lv6	153	43	,	,	,
cord-300194-nsp53lv6	153	44	Asn501	asn501	UH
cord-300194-nsp53lv6	153	45	,	,	,
cord-300194-nsp53lv6	153	46	Gly502	gly502	ADD
cord-300194-nsp53lv6	153	47	and	and	CC
cord-300194-nsp53lv6	153	48	Tyr505	tyr505	NN
cord-300194-nsp53lv6	153	49	to	to	TO
cord-300194-nsp53lv6	153	50	fa	fa	XX
cord-300194-nsp53lv6	153	51	ilitate	ilitate	NNP
cord-300194-nsp53lv6	153	52	the	the	DT
cord-300194-nsp53lv6	153	53	inding	inding	NN
cord-300194-nsp53lv6	153	54	of	of	IN
cord-300194-nsp53lv6	153	55	the	the	DT
cord-300194-nsp53lv6	153	56	re	re	NNP
cord-300194-nsp53lv6	153	57	eptors	eptor	NNS
cord-300194-nsp53lv6	153	58	t	t	NNP
cord-300194-nsp53lv6	154	1	is	be	VBZ
cord-300194-nsp53lv6	154	2	fas	fas	NNP
cord-300194-nsp53lv6	154	3	inating	inate	VBG
cord-300194-nsp53lv6	154	4	to	to	TO
cord-300194-nsp53lv6	154	5	see	see	VB
cord-300194-nsp53lv6	154	6	that	that	DT
cord-300194-nsp53lv6	154	7	at	at	IN
cord-300194-nsp53lv6	154	8	C	c	NN
cord-300194-nsp53lv6	154	9	and	and	CC
cord-300194-nsp53lv6	154	10	more	more	JJR
cord-300194-nsp53lv6	154	11	interestingly	interestingly	RB
cord-300194-nsp53lv6	154	12	at	at	IN
cord-300194-nsp53lv6	154	13	C	C	NNP
cord-300194-nsp53lv6	154	14	,	,	,
cord-300194-nsp53lv6	154	15	the	the	DT
cord-300194-nsp53lv6	154	16	RBM	RBM	NNP
cord-300194-nsp53lv6	154	17	motif	motif	NN
cord-300194-nsp53lv6	154	18	is	be	VBZ
cord-300194-nsp53lv6	154	19	in	in	IN
cord-300194-nsp53lv6	154	20	a	a	DT
cord-300194-nsp53lv6	154	21	closed	closed	JJ
cord-300194-nsp53lv6	154	22	loop	loop	NN
cord-300194-nsp53lv6	154	23	conformation	conformation	NN
cord-300194-nsp53lv6	154	24	and	and	CC
cord-300194-nsp53lv6	154	25	very	very	RB
cord-300194-nsp53lv6	154	26	compact	compact	JJ
cord-300194-nsp53lv6	154	27	which	which	WDT
cord-300194-nsp53lv6	154	28	hinders	hinder	VBZ
cord-300194-nsp53lv6	154	29	its	-PRON-	PRP$
cord-300194-nsp53lv6	154	30	association	association	NN
cord-300194-nsp53lv6	154	31	with	with	IN
cord-300194-nsp53lv6	154	32	the	the	DT
cord-300194-nsp53lv6	154	33	partner	partner	NN
cord-300194-nsp53lv6	154	34	proteins	protein	NNS
cord-300194-nsp53lv6	154	35	.	.	.
cord-300194-nsp53lv6	155	1	15	15	CD
cord-300194-nsp53lv6	156	1	To	to	TO
cord-300194-nsp53lv6	156	2	validate	validate	VB
cord-300194-nsp53lv6	156	3	the	the	DT
cord-300194-nsp53lv6	156	4	findings	finding	NNS
cord-300194-nsp53lv6	156	5	,	,	,
cord-300194-nsp53lv6	156	6	we	-PRON-	PRP
cord-300194-nsp53lv6	156	7	ran	run	VBD
cord-300194-nsp53lv6	156	8	another	another	DT
cord-300194-nsp53lv6	156	9	simulation	simulation	NN
cord-300194-nsp53lv6	156	10	of	of	IN
cord-300194-nsp53lv6	156	11	the	the	DT
cord-300194-nsp53lv6	156	12	Spike	Spike	NNP
cord-300194-nsp53lv6	156	13	protein	protein	NN
cord-300194-nsp53lv6	156	14	at	at	IN
cord-300194-nsp53lv6	156	15	a	a	DT
cord-300194-nsp53lv6	156	16	higher	high	JJR
cord-300194-nsp53lv6	156	17	temperature	temperature	NN
cord-300194-nsp53lv6	156	18	of	of	IN
cord-300194-nsp53lv6	156	19	70	70	CD
cord-300194-nsp53lv6	156	20	C.	C.	NNP
cord-300194-nsp53lv6	156	21	After	after	IN
cord-300194-nsp53lv6	156	22	100ns	100ns	CD
cord-300194-nsp53lv6	156	23	of	of	IN
cord-300194-nsp53lv6	156	24	simulation	simulation	NN
cord-300194-nsp53lv6	156	25	,	,	,
cord-300194-nsp53lv6	156	26	we	-PRON-	PRP
cord-300194-nsp53lv6	156	27	found	find	VBD
cord-300194-nsp53lv6	156	28	that	that	IN
cord-300194-nsp53lv6	156	29	significant	significant	JJ
cord-300194-nsp53lv6	156	30	similarity	similarity	NN
cord-300194-nsp53lv6	156	31	between	between	IN
cord-300194-nsp53lv6	156	32	the	the	DT
cord-300194-nsp53lv6	156	33	closed	closed	JJ
cord-300194-nsp53lv6	156	34	conformation	conformation	NN
cord-300194-nsp53lv6	156	35	observed	observe	VBN
cord-300194-nsp53lv6	156	36	at	at	IN
cord-300194-nsp53lv6	156	37	50	50	CD
cord-300194-nsp53lv6	156	38	C	c	NN
cord-300194-nsp53lv6	156	39	and	and	CC
cord-300194-nsp53lv6	156	40	the	the	DT
cord-300194-nsp53lv6	156	41	conformation	conformation	NN
cord-300194-nsp53lv6	156	42	at	at	IN
cord-300194-nsp53lv6	156	43	70	70	CD
cord-300194-nsp53lv6	156	44	C.	c.	NN
cord-300194-nsp53lv6	157	1	The	the	DT
cord-300194-nsp53lv6	157	2	RBM	RBM	NNP
cord-300194-nsp53lv6	157	3	residues	residue	NNS
cord-300194-nsp53lv6	157	4	,	,	,
cord-300194-nsp53lv6	157	5	specifically	specifically	RB
cord-300194-nsp53lv6	157	6	Phe456	phe456	IN
cord-300194-nsp53lv6	157	7	,	,	,
cord-300194-nsp53lv6	157	8	Ala475	ala475	UH
cord-300194-nsp53lv6	157	9	,	,	,
cord-300194-nsp53lv6	157	10	Phe486	phe486	ADD
cord-300194-nsp53lv6	157	11	,	,	,
cord-300194-nsp53lv6	157	12	Asn487	asn487	UH
cord-300194-nsp53lv6	157	13	,	,	,
cord-300194-nsp53lv6	157	14	Tyr489	tyr489	CD
cord-300194-nsp53lv6	157	15	,	,	,
cord-300194-nsp53lv6	157	16	Gln493	Gln493	NNP
cord-300194-nsp53lv6	157	17	,	,	,
cord-300194-nsp53lv6	157	18	Gly496	Gly496	NNP
cord-300194-nsp53lv6	157	19	,	,	,
cord-300194-nsp53lv6	157	20	Gln498	gln498	CD
cord-300194-nsp53lv6	157	21	,	,	,
cord-300194-nsp53lv6	157	22	Thr500	thr500	UH
cord-300194-nsp53lv6	157	23	,	,	,
cord-300194-nsp53lv6	157	24	Asn501	asn501	UH
cord-300194-nsp53lv6	157	25	,	,	,
cord-300194-nsp53lv6	157	26	Gly502	gly502	ADD
cord-300194-nsp53lv6	157	27	and	and	CC
cord-300194-nsp53lv6	157	28	Tyr505	Tyr505	NNS
cord-300194-nsp53lv6	157	29	were	be	VBD
cord-300194-nsp53lv6	157	30	found	find	VBN
cord-300194-nsp53lv6	157	31	to	to	TO
cord-300194-nsp53lv6	157	32	be	be	VB
cord-300194-nsp53lv6	157	33	clearly	clearly	RB
cord-300194-nsp53lv6	157	34	buried	bury	VBN
cord-300194-nsp53lv6	157	35	between	between	IN
cord-300194-nsp53lv6	157	36	the	the	DT
cord-300194-nsp53lv6	157	37	interchain	interchain	JJ
cord-300194-nsp53lv6	157	38	subunits	subunit	NNS
cord-300194-nsp53lv6	157	39	at	at	IN
cord-300194-nsp53lv6	157	40	70	70	CD
cord-300194-nsp53lv6	157	41	C	c	NN
cord-300194-nsp53lv6	157	42	(	(	-LRB-
cord-300194-nsp53lv6	157	43	Figure	Figure	NNP
cord-300194-nsp53lv6	157	44	7	7	CD
cord-300194-nsp53lv6	157	45	,	,	,
cord-300194-nsp53lv6	157	46	of	of	IN
cord-300194-nsp53lv6	157	47	the	the	DT
cord-300194-nsp53lv6	157	48	coronaviruses	coronaviruse	NNS
cord-300194-nsp53lv6	157	49	inside	inside	IN
cord-300194-nsp53lv6	157	50	the	the	DT
cord-300194-nsp53lv6	157	51	host	host	NN
cord-300194-nsp53lv6	157	52	cells	cell	NNS
cord-300194-nsp53lv6	157	53	.	.	.
cord-300194-nsp53lv6	158	1	It	-PRON-	PRP
cord-300194-nsp53lv6	158	2	exists	exist	VBZ
cord-300194-nsp53lv6	158	3	as	as	IN
cord-300194-nsp53lv6	158	4	a	a	DT
cord-300194-nsp53lv6	158	5	homotrimer	homotrimer	NN
cord-300194-nsp53lv6	158	6	and	and	CC
cord-300194-nsp53lv6	158	7	is	be	VBZ
cord-300194-nsp53lv6	158	8	partly	partly	RB
cord-300194-nsp53lv6	158	9	exposed	expose	VBN
cord-300194-nsp53lv6	158	10	to	to	IN
cord-300194-nsp53lv6	158	11	the	the	DT
cord-300194-nsp53lv6	158	12	outer	outer	JJ
cord-300194-nsp53lv6	158	13	environment	environment	NN
cord-300194-nsp53lv6	158	14	and	and	CC
cord-300194-nsp53lv6	158	15	partly	partly	RB
cord-300194-nsp53lv6	158	16	immersed	immerse	VBN
cord-300194-nsp53lv6	158	17	inside	inside	IN
cord-300194-nsp53lv6	158	18	the	the	DT
cord-300194-nsp53lv6	158	19	lipid	lipid	NN
cord-300194-nsp53lv6	158	20	bilayer	bilayer	NN
cord-300194-nsp53lv6	158	21	of	of	IN
cord-300194-nsp53lv6	158	22	the	the	DT
cord-300194-nsp53lv6	158	23	viral	viral	JJ
cord-300194-nsp53lv6	158	24	envelope	envelope	NN
cord-300194-nsp53lv6	158	25	.	.	.
cord-300194-nsp53lv6	159	1	Here	here	RB
cord-300194-nsp53lv6	159	2	,	,	,
cord-300194-nsp53lv6	159	3	we	-PRON-	PRP
cord-300194-nsp53lv6	159	4	studied	study	VBD
cord-300194-nsp53lv6	159	5	the	the	DT
cord-300194-nsp53lv6	159	6	differential	differential	JJ
cord-300194-nsp53lv6	159	7	response	response	NN
cord-300194-nsp53lv6	159	8	of	of	IN
cord-300194-nsp53lv6	159	9	the	the	DT
cord-300194-nsp53lv6	159	10	Spike	Spike	NNP
cord-300194-nsp53lv6	159	11	protein	protein	NN
cord-300194-nsp53lv6	159	12	at	at	IN
cord-300194-nsp53lv6	159	13	different	different	JJ
cord-300194-nsp53lv6	159	14	temperature	temperature	NN
cord-300194-nsp53lv6	159	15	conditions	condition	NNS
cord-300194-nsp53lv6	159	16	.	.	.
cord-300194-nsp53lv6	160	1	Our	-PRON-	PRP$
cord-300194-nsp53lv6	160	2	results	result	NNS
cord-300194-nsp53lv6	160	3	show	show	VBP
cord-300194-nsp53lv6	160	4	that	that	IN
cord-300194-nsp53lv6	160	5	the	the	DT
cord-300194-nsp53lv6	160	6	S2	S2	NNP
cord-300194-nsp53lv6	160	7	transmembrane	transmembrane	NN
cord-300194-nsp53lv6	160	8	domain	domain	NN
cord-300194-nsp53lv6	160	9	remains	remain	VBZ
cord-300194-nsp53lv6	160	10	stable	stable	JJ
cord-300194-nsp53lv6	160	11	even	even	RB
cord-300194-nsp53lv6	160	12	without	without	IN
cord-300194-nsp53lv6	160	13	the	the	DT
cord-300194-nsp53lv6	160	14	bilayer	bilayer	NN
cord-300194-nsp53lv6	160	15	membrane	membrane	NN
cord-300194-nsp53lv6	160	16	,	,	,
cord-300194-nsp53lv6	160	17	whereas	whereas	IN
cord-300194-nsp53lv6	160	18	the	the	DT
cord-300194-nsp53lv6	160	19	solvent	solvent	NN
cord-300194-nsp53lv6	160	20	exposed	expose	VBD
cord-300194-nsp53lv6	160	21	S1	s1	NN
cord-300194-nsp53lv6	160	22	domain	domain	NN
cord-300194-nsp53lv6	160	23	is	be	VBZ
cord-300194-nsp53lv6	160	24	quite	quite	RB
cord-300194-nsp53lv6	160	25	flexible	flexible	JJ
cord-300194-nsp53lv6	160	26	.	.	.
cord-300194-nsp53lv6	161	1	Moreover	moreover	RB
cord-300194-nsp53lv6	161	2	,	,	,
cord-300194-nsp53lv6	161	3	the	the	DT
cord-300194-nsp53lv6	161	4	S1	s1	NN
cord-300194-nsp53lv6	161	5	comprises	comprise	VBZ
cord-300194-nsp53lv6	161	6	of	of	IN
cord-300194-nsp53lv6	161	7	two	two	CD
cord-300194-nsp53lv6	161	8	subdomains	subdomain	NNS
cord-300194-nsp53lv6	161	9	,	,	,
cord-300194-nsp53lv6	161	10	namely	namely	RB
cord-300194-nsp53lv6	161	11	N	n	CD
cord-300194-nsp53lv6	161	12	-	-	HYPH
cord-300194-nsp53lv6	161	13	terminal	terminal	NN
cord-300194-nsp53lv6	161	14	domain	domain	NN
cord-300194-nsp53lv6	161	15	(	(	-LRB-
cord-300194-nsp53lv6	161	16	NTD	NTD	NNP
cord-300194-nsp53lv6	161	17	)	)	-RRB-
cord-300194-nsp53lv6	161	18	and	and	CC
cord-300194-nsp53lv6	161	19	the	the	DT
cord-300194-nsp53lv6	161	20	receptor	receptor	NN
cord-300194-nsp53lv6	161	21	binding	bind	VBG
cord-300194-nsp53lv6	161	22	domain	domain	NN
cord-300194-nsp53lv6	161	23	(	(	-LRB-
cord-300194-nsp53lv6	161	24	RBD	RBD	NNP
cord-300194-nsp53lv6	161	25	)	)	-RRB-
cord-300194-nsp53lv6	161	26	.	.	.
cord-300194-nsp53lv6	162	1	The	the	DT
cord-300194-nsp53lv6	162	2	simulations	simulation	NNS
cord-300194-nsp53lv6	162	3	results	result	NNS
cord-300194-nsp53lv6	162	4	show	show	VBP
cord-300194-nsp53lv6	162	5	that	that	IN
cord-300194-nsp53lv6	162	6	the	the	DT
cord-300194-nsp53lv6	162	7	RBD	RBD	NNP
cord-300194-nsp53lv6	162	8	is	be	VBZ
cord-300194-nsp53lv6	162	9	relatively	relatively	RB
cord-300194-nsp53lv6	162	10	less	less	RBR
cord-300194-nsp53lv6	162	11	mobile	mobile	JJ
cord-300194-nsp53lv6	162	12	.	.	.
cord-300194-nsp53lv6	163	1	Its	-PRON-	PRP$
cord-300194-nsp53lv6	163	2	flexibility	flexibility	NN
cord-300194-nsp53lv6	163	3	is	be	VBZ
cord-300194-nsp53lv6	163	4	limited	limit	VBN
cord-300194-nsp53lv6	163	5	only	only	RB
cord-300194-nsp53lv6	163	6	to	to	IN
cord-300194-nsp53lv6	163	7	the	the	DT
cord-300194-nsp53lv6	163	8	receptor	receptor	NN
cord-300194-nsp53lv6	163	9	binding	bind	VBG
cord-300194-nsp53lv6	163	10	motif	motif	NN
cord-300194-nsp53lv6	163	11	or	or	CC
cord-300194-nsp53lv6	163	12	RBM	RBM	NNP
cord-300194-nsp53lv6	163	13	which	which	WDT
cord-300194-nsp53lv6	163	14	interacts	interact	VBZ
cord-300194-nsp53lv6	163	15	with	with	IN
cord-300194-nsp53lv6	163	16	the	the	DT
cord-300194-nsp53lv6	163	17	Angiotensin	Angiotensin	NNP
cord-300194-nsp53lv6	163	18	Converting	convert	VBG
cord-300194-nsp53lv6	163	19	enzyme	enzyme	NN
cord-300194-nsp53lv6	163	20	2	2	CD
cord-300194-nsp53lv6	163	21	(	(	-LRB-
cord-300194-nsp53lv6	163	22	ACE2	ACE2	NNP
cord-300194-nsp53lv6	163	23	)	)	-RRB-
cord-300194-nsp53lv6	163	24	,	,	,
cord-300194-nsp53lv6	163	25	its	-PRON-	PRP$
cord-300194-nsp53lv6	163	26	human	human	JJ
cord-300194-nsp53lv6	163	27	receptor	receptor	NN
cord-300194-nsp53lv6	163	28	.	.	.
cord-300194-nsp53lv6	164	1	However	however	RB
cord-300194-nsp53lv6	164	2	,	,	,
cord-300194-nsp53lv6	164	3	the	the	DT
cord-300194-nsp53lv6	164	4	NTD	NTD	NNP
cord-300194-nsp53lv6	164	5	was	be	VBD
cord-300194-nsp53lv6	164	6	found	find	VBN
cord-300194-nsp53lv6	164	7	to	to	TO
cord-300194-nsp53lv6	164	8	be	be	VB
cord-300194-nsp53lv6	164	9	quite	quite	RB
cord-300194-nsp53lv6	164	10	mobile	mobile	JJ
cord-300194-nsp53lv6	164	11	.	.	.
cord-300194-nsp53lv6	165	1	Although	although	IN
cord-300194-nsp53lv6	165	2	,	,	,
cord-300194-nsp53lv6	165	3	the	the	DT
cord-300194-nsp53lv6	165	4	NTD	NTD	NNP
cord-300194-nsp53lv6	165	5	does	do	VBZ
cord-300194-nsp53lv6	165	6	n't	not	RB
cord-300194-nsp53lv6	165	7	dire	dire	VB
cord-300194-nsp53lv6	165	8	tly	tly	RB
cord-300194-nsp53lv6	165	9	intera	intera	NNP
cord-300194-nsp53lv6	165	10	t	t	NNP
cord-300194-nsp53lv6	165	11	with	with	IN
cord-300194-nsp53lv6	165	12	the	the	DT
cord-300194-nsp53lv6	165	13	re	re	NNP
cord-300194-nsp53lv6	165	14	eptor	eptor	NNP
cord-300194-nsp53lv6	165	15	in	in	IN
cord-300194-nsp53lv6	165	16	humans	human	NNS
cord-300194-nsp53lv6	165	17	,	,	,
cord-300194-nsp53lv6	165	18	it	-PRON-	PRP
cord-300194-nsp53lv6	165	19	has	have	VBZ
cord-300194-nsp53lv6	165	20	been	be	VBN
cord-300194-nsp53lv6	165	21	found	find	VBN
cord-300194-nsp53lv6	165	22	to	to	TO
cord-300194-nsp53lv6	165	23	bind	bind	VB
cord-300194-nsp53lv6	165	24	to	to	IN
cord-300194-nsp53lv6	165	25	receptors	receptor	NNS
cord-300194-nsp53lv6	165	26	in	in	IN
cord-300194-nsp53lv6	165	27	other	other	JJ
cord-300194-nsp53lv6	165	28	mammals	mammal	NNS
cord-300194-nsp53lv6	165	29	[	[	-LRB-
cord-300194-nsp53lv6	165	30	31	31	CD
cord-300194-nsp53lv6	165	31	]	]	-RRB-
cord-300194-nsp53lv6	165	32	.	.	.
cord-300194-nsp53lv6	166	1	The	the	DT
cord-300194-nsp53lv6	166	2	flexible	flexible	JJ
cord-300194-nsp53lv6	166	3	NTD	NTD	NNP
cord-300194-nsp53lv6	166	4	hosts	host	VBZ
cord-300194-nsp53lv6	166	5	a	a	DT
cord-300194-nsp53lv6	166	6	large	large	JJ
cord-300194-nsp53lv6	166	7	number	number	NN
cord-300194-nsp53lv6	166	8	of	of	IN
cord-300194-nsp53lv6	166	9	charged	charge	VBN
cord-300194-nsp53lv6	166	10	residues	residue	NNS
cord-300194-nsp53lv6	166	11	on	on	IN
cord-300194-nsp53lv6	166	12	the	the	DT
cord-300194-nsp53lv6	166	13	top	top	JJ
cord-300194-nsp53lv6	166	14	layer	layer	NN
cord-300194-nsp53lv6	166	15	of	of	IN
cord-300194-nsp53lv6	166	16	its	-PRON-	PRP$
cord-300194-nsp53lv6	166	17	tri	tri	JJ
cord-300194-nsp53lv6	166	18	-	-	JJ
cord-300194-nsp53lv6	166	19	layered	layered	JJ
cord-300194-nsp53lv6	166	20	beta	beta	NN
cord-300194-nsp53lv6	166	21	sandwi	sandwi	NNP
cord-300194-nsp53lv6	166	22	h	h	NNP
cord-300194-nsp53lv6	166	23	ar	ar	NNP
cord-300194-nsp53lv6	166	24	hite	hite	NNP
cord-300194-nsp53lv6	166	25	ture	ture	NNP
cord-300194-nsp53lv6	166	26	owever	owever	RB
cord-300194-nsp53lv6	166	27	at	at	IN
cord-300194-nsp53lv6	166	28	-C	-C	NNS
cord-300194-nsp53lv6	166	29	of	of	IN
cord-300194-nsp53lv6	166	30	temperature	temperature	NN
cord-300194-nsp53lv6	167	1	,	,	,
cord-300194-nsp53lv6	167	2	the	the	DT
cord-300194-nsp53lv6	167	3	polar	polar	JJ
cord-300194-nsp53lv6	167	4	residues	residue	NNS
cord-300194-nsp53lv6	167	5	were	be	VBD
cord-300194-nsp53lv6	167	6	found	find	VBN
cord-300194-nsp53lv6	167	7	to	to	TO
cord-300194-nsp53lv6	167	8	be	be	VB
cord-300194-nsp53lv6	167	9	less	less	RBR
cord-300194-nsp53lv6	167	10	solvent	solvent	NN
cord-300194-nsp53lv6	167	11	exposed	expose	VBN
cord-300194-nsp53lv6	167	12	.	.	.
cord-300194-nsp53lv6	168	1	The	the	DT
cord-300194-nsp53lv6	168	2	similarity	similarity	NN
cord-300194-nsp53lv6	168	3	of	of	IN
cord-300194-nsp53lv6	168	4	the	the	DT
cord-300194-nsp53lv6	168	5	NTD	NTD	NNP
cord-300194-nsp53lv6	168	6	sequence	sequence	NN
cord-300194-nsp53lv6	168	7	with	with	IN
cord-300194-nsp53lv6	168	8	the	the	DT
cord-300194-nsp53lv6	168	9	several	several	JJ
cord-300194-nsp53lv6	168	10	human	human	JJ
cord-300194-nsp53lv6	168	11	receptors	receptor	NNS
cord-300194-nsp53lv6	168	12	such	such	JJ
cord-300194-nsp53lv6	168	13	as	as	IN
cord-300194-nsp53lv6	168	14	Ephrins	Ephrins	NNP
cord-300194-nsp53lv6	168	15	,	,	,
cord-300194-nsp53lv6	168	16	Briakunumab	Briakunumab	NNP
cord-300194-nsp53lv6	168	17	,	,	,
cord-300194-nsp53lv6	168	18	anti	anti	JJ
cord-300194-nsp53lv6	168	19	-	-	NNP
cord-300194-nsp53lv6	168	20	TSLP	TSLP	NNP
cord-300194-nsp53lv6	168	21	,	,	,
cord-300194-nsp53lv6	168	22	etc	etc	FW
cord-300194-nsp53lv6	168	23	indicated	indicate	VBD
cord-300194-nsp53lv6	168	24	a	a	DT
cord-300194-nsp53lv6	168	25	possibility	possibility	NN
cord-300194-nsp53lv6	168	26	of	of	IN
cord-300194-nsp53lv6	168	27	the	the	DT
cord-300194-nsp53lv6	168	28	subdomain	subdomain	NN
cord-300194-nsp53lv6	168	29	to	to	TO
cord-300194-nsp53lv6	168	30	be	be	VB
cord-300194-nsp53lv6	168	31	involved	involve	VBN
cord-300194-nsp53lv6	168	32	in	in	IN
cord-300194-nsp53lv6	168	33	binding	bind	VBG
cord-300194-nsp53lv6	168	34	to	to	IN
cord-300194-nsp53lv6	168	35	alternate	alternate	JJ
cord-300194-nsp53lv6	168	36	human	human	JJ
cord-300194-nsp53lv6	168	37	proteins	protein	NNS
cord-300194-nsp53lv6	168	38	.	.	.
cord-300194-nsp53lv6	169	1	The	the	DT
cord-300194-nsp53lv6	169	2	RBM	RBM	NNP
cord-300194-nsp53lv6	169	3	present	present	NN
cord-300194-nsp53lv6	169	4	on	on	IN
cord-300194-nsp53lv6	169	5	the	the	DT
cord-300194-nsp53lv6	169	6	RBD	RBD	NNP
cord-300194-nsp53lv6	169	7	is	be	VBZ
cord-300194-nsp53lv6	169	8	very	very	RB
cord-300194-nsp53lv6	169	9	crucial	crucial	JJ
cord-300194-nsp53lv6	169	10	in	in	IN
cord-300194-nsp53lv6	169	11	initial	initial	JJ
cord-300194-nsp53lv6	169	12	protein	protein	NN
cord-300194-nsp53lv6	169	13	-	-	HYPH
cord-300194-nsp53lv6	169	14	protein	protein	NN
cord-300194-nsp53lv6	169	15	interaction	interaction	NN
cord-300194-nsp53lv6	169	16	between	between	IN
cord-300194-nsp53lv6	169	17	the	the	DT
cord-300194-nsp53lv6	169	18	host	host	NN
cord-300194-nsp53lv6	169	19	and	and	CC
cord-300194-nsp53lv6	169	20	virus	virus	NN
cord-300194-nsp53lv6	169	21	.	.	.
cord-300194-nsp53lv6	170	1	We	-PRON-	PRP
cord-300194-nsp53lv6	170	2	found	find	VBD
cord-300194-nsp53lv6	170	3	that	that	IN
cord-300194-nsp53lv6	170	4	this	this	DT
cord-300194-nsp53lv6	170	5	domain	domain	NN
cord-300194-nsp53lv6	170	6	is	be	VBZ
cord-300194-nsp53lv6	170	7	equilibration	equilibration	NN
cord-300194-nsp53lv6	170	8	,	,	,
cord-300194-nsp53lv6	170	9	by	by	IN
cord-300194-nsp53lv6	170	10	maintaining	maintain	VBG
cord-300194-nsp53lv6	170	11	harmonic	harmonic	JJ
cord-300194-nsp53lv6	170	12	restraints	restraint	NNS
cord-300194-nsp53lv6	170	13	on	on	IN
cord-300194-nsp53lv6	170	14	the	the	DT
cord-300194-nsp53lv6	170	15	protein	protein	NN
cord-300194-nsp53lv6	170	16	heavy	heavy	JJ
cord-300194-nsp53lv6	170	17	atoms	atom	NNS
cord-300194-nsp53lv6	170	18	,	,	,
cord-300194-nsp53lv6	170	19	the	the	DT
cord-300194-nsp53lv6	170	20	system	system	NN
cord-300194-nsp53lv6	170	21	was	be	VBD
cord-300194-nsp53lv6	170	22	gradually	gradually	RB
cord-300194-nsp53lv6	170	23	heated	heat	VBN
cord-300194-nsp53lv6	170	24	to	to	IN
cord-300194-nsp53lv6	170	25	300	300	CD
cord-300194-nsp53lv6	170	26	K	k	NN
cord-300194-nsp53lv6	170	27	in	in	IN
cord-300194-nsp53lv6	170	28	a	a	DT
cord-300194-nsp53lv6	170	29	canonical	canonical	JJ
cord-300194-nsp53lv6	170	30	ensemble	ensemble	NN
cord-300194-nsp53lv6	170	31	.	.	.
cord-300194-nsp53lv6	171	1	The	the	DT
cord-300194-nsp53lv6	171	2	harmonic	harmonic	JJ
cord-300194-nsp53lv6	171	3	restraints	restraint	NNS
cord-300194-nsp53lv6	171	4	were	be	VBD
cord-300194-nsp53lv6	171	5	gradually	gradually	RB
cord-300194-nsp53lv6	171	6	reduced	reduce	VBN
cord-300194-nsp53lv6	171	7	to	to	IN
cord-300194-nsp53lv6	171	8	zero	zero	CD
cord-300194-nsp53lv6	171	9	and	and	CC
cord-300194-nsp53lv6	171	10	solvent	solvent	NN
cord-300194-nsp53lv6	171	11	density	density	NN
cord-300194-nsp53lv6	171	12	was	be	VBD
cord-300194-nsp53lv6	171	13	adjusted	adjust	VBN
cord-300194-nsp53lv6	171	14	under	under	IN
cord-300194-nsp53lv6	171	15	isobaric	isobaric	JJ
cord-300194-nsp53lv6	171	16	and	and	CC
cord-300194-nsp53lv6	171	17	isothermal	isothermal	JJ
cord-300194-nsp53lv6	171	18	conditions	condition	NNS
cord-300194-nsp53lv6	171	19	at	at	IN
cord-300194-nsp53lv6	171	20	1	1	CD
cord-300194-nsp53lv6	171	21	atm	atm	NN
cord-300194-nsp53lv6	171	22	and	and	CC
cord-300194-nsp53lv6	171	23	300	300	CD
cord-300194-nsp53lv6	171	24	K.	K.	NNP
cord-300194-nsp53lv6	172	1	This	this	DT
cord-300194-nsp53lv6	172	2	was	be	VBD
cord-300194-nsp53lv6	172	3	followed	follow	VBN
cord-300194-nsp53lv6	172	4	by	by	IN
cord-300194-nsp53lv6	172	5	500ps	500ps	NNP
cord-300194-nsp53lv6	172	6	NVT	NVT	NNP
cord-300194-nsp53lv6	172	7	and	and	CC
cord-300194-nsp53lv6	172	8	500ps	500ps	JJ
cord-300194-nsp53lv6	172	9	NPT	npt	NN
cord-300194-nsp53lv6	172	10	equilibration	equilibration	NN
cord-300194-nsp53lv6	172	11	with	with	IN
cord-300194-nsp53lv6	172	12	harmonic	harmonic	JJ
cord-300194-nsp53lv6	172	13	restraints	restraint	NNS
cord-300194-nsp53lv6	172	14	of	of	IN
cord-300194-nsp53lv6	172	15	1000	1000	CD
cord-300194-nsp53lv6	172	16	kJ	kJ	NNP
cord-300194-nsp53lv6	172	17	mol	mol	NNP
cord-300194-nsp53lv6	172	18	-1	-1	NNP
cord-300194-nsp53lv6	172	19	nm	nm	NNP
cord-300194-nsp53lv6	172	20	-2	-2	NNP
cord-300194-nsp53lv6	172	21	on	on	IN
cord-300194-nsp53lv6	172	22	the	the	DT
cord-300194-nsp53lv6	172	23	heavy	heavy	JJ
cord-300194-nsp53lv6	172	24	atoms	atom	NNS
cord-300194-nsp53lv6	172	25	.	.	.
cord-300194-nsp53lv6	173	1	Production	production	NN
cord-300194-nsp53lv6	173	2	run	run	VBN
cord-300194-nsp53lv6	173	3	for	for	IN
cord-300194-nsp53lv6	173	4	all	all	PDT
cord-300194-nsp53lv6	173	5	the	the	DT
cord-300194-nsp53lv6	173	6	systems	system	NNS
cord-300194-nsp53lv6	173	7	was	be	VBD
cord-300194-nsp53lv6	173	8	carried	carry	VBN
cord-300194-nsp53lv6	173	9	out	out	RP
cord-300194-nsp53lv6	173	10	for	for	IN
cord-300194-nsp53lv6	173	11	200ns	200ns	NNP
cord-300194-nsp53lv6	173	12	till	till	IN
cord-300194-nsp53lv6	173	13	it	-PRON-	PRP
cord-300194-nsp53lv6	173	14	reached	reach	VBD
cord-300194-nsp53lv6	173	15	a	a	DT
cord-300194-nsp53lv6	173	16	stable	stable	JJ
cord-300194-nsp53lv6	173	17	RMSD	rmsd	NN
cord-300194-nsp53lv6	173	18	.	.	.
cord-300194-nsp53lv6	174	1	All	all	DT
cord-300194-nsp53lv6	174	2	simulations	simulation	NNS
cord-300194-nsp53lv6	174	3	were	be	VBD
cord-300194-nsp53lv6	174	4	carried	carry	VBN
cord-300194-nsp53lv6	174	5	out	out	RP
cord-300194-nsp53lv6	174	6	in	in	IN
cord-300194-nsp53lv6	174	7	Gromacs	Gromacs	NNP
cord-300194-nsp53lv6	174	8	2020	2020	CD
cord-300194-nsp53lv6	174	9	with	with	IN
cord-300194-nsp53lv6	174	10	AMBERff99SB	AMBERff99SB	NNP
cord-300194-nsp53lv6	174	11	-	-	HYPH
cord-300194-nsp53lv6	174	12	ILDN	ILDN	NNP
cord-300194-nsp53lv6	174	13	forcefield	forcefield	NN
cord-300194-nsp53lv6	174	14	for	for	IN
cord-300194-nsp53lv6	174	15	proteins	protein	NNS
cord-300194-nsp53lv6	174	16	[	[	-LRB-
cord-300194-nsp53lv6	174	17	40	40	CD
cord-300194-nsp53lv6	174	18	,	,	,
cord-300194-nsp53lv6	174	19	41	41	CD
cord-300194-nsp53lv6	174	20	]	]	-RRB-
cord-300194-nsp53lv6	174	21	.	.	.
cord-300194-nsp53lv6	175	1	The	the	DT
cord-300194-nsp53lv6	175	2	long	long	JJ
cord-300194-nsp53lv6	175	3	-	-	HYPH
cord-300194-nsp53lv6	175	4	range	range	NN
cord-300194-nsp53lv6	175	5	electrostatic	electrostatic	JJ
cord-300194-nsp53lv6	175	6	interactions	interaction	NNS
cord-300194-nsp53lv6	175	7	were	be	VBD
cord-300194-nsp53lv6	175	8	treated	treat	VBN
cord-300194-nsp53lv6	175	9	by	by	IN
cord-300194-nsp53lv6	175	10	using	use	VBG
cord-300194-nsp53lv6	175	11	Particle	Particle	NNP
cord-300194-nsp53lv6	175	12	-	-	HYPH
cord-300194-nsp53lv6	175	13	Mesh	Mesh	NNP
cord-300194-nsp53lv6	175	14	Ewald	Ewald	NNP
cord-300194-nsp53lv6	175	15	sum	sum	VBP
cord-300194-nsp53lv6	175	16	and	and	CC
cord-300194-nsp53lv6	175	17	SHAKE	shake	NN
cord-300194-nsp53lv6	175	18	was	be	VBD
cord-300194-nsp53lv6	175	19	used	use	VBN
cord-300194-nsp53lv6	175	20	to	to	TO
cord-300194-nsp53lv6	175	21	constrain	constrain	VB
cord-300194-nsp53lv6	175	22	all	all	DT
cord-300194-nsp53lv6	175	23	bonds	bond	NNS
cord-300194-nsp53lv6	175	24	involving	involve	VBG
cord-300194-nsp53lv6	175	25	hydrogen	hydrogen	NN
cord-300194-nsp53lv6	175	26	atoms	atom	NNS
cord-300194-nsp53lv6	175	27	.	.	.
cord-300194-nsp53lv6	176	1	After	after	IN
cord-300194-nsp53lv6	176	2	equilibration	equilibration	NN
cord-300194-nsp53lv6	176	3	,	,	,
cord-300194-nsp53lv6	176	4	systems	system	NNS
cord-300194-nsp53lv6	176	5	were	be	VBD
cord-300194-nsp53lv6	176	6	heated	heat	VBN
cord-300194-nsp53lv6	176	7	or	or	CC
cord-300194-nsp53lv6	176	8	cooled	cool	VBN
cord-300194-nsp53lv6	176	9	at	at	IN
cord-300194-nsp53lv6	176	10	different	different	JJ
cord-300194-nsp53lv6	176	11	temperatures	temperature	NNS
cord-300194-nsp53lv6	176	12	(	(	-LRB-
cord-300194-nsp53lv6	176	13	Table	Table	NNP
cord-300194-nsp53lv6	176	14	S1	S1	NNP
cord-300194-nsp53lv6	176	15	)	)	-RRB-
cord-300194-nsp53lv6	176	16	and	and	CC
cord-300194-nsp53lv6	176	17	simulated	simulate	VBN
cord-300194-nsp53lv6	176	18	for	for	IN
cord-300194-nsp53lv6	176	19	200ns	200ns	NNP
cord-300194-nsp53lv6	176	20	.	.	.
cord-300194-nsp53lv6	177	1	All	all	DT
cord-300194-nsp53lv6	177	2	analyses	analysis	NNS
cord-300194-nsp53lv6	177	3	were	be	VBD
cord-300194-nsp53lv6	177	4	carried	carry	VBN
cord-300194-nsp53lv6	177	5	out	out	RP
cord-300194-nsp53lv6	177	6	using	use	VBG
cord-300194-nsp53lv6	177	7	Gromacs	Gromacs	NNP
cord-300194-nsp53lv6	177	8	analysis	analysis	NN
cord-300194-nsp53lv6	177	9	tools	tool	NNS
cord-300194-nsp53lv6	177	10	[	[	-LRB-
cord-300194-nsp53lv6	177	11	40	40	CD
cord-300194-nsp53lv6	177	12	]	]	-RRB-
cord-300194-nsp53lv6	177	13	.	.	.
cord-300194-nsp53lv6	178	1	Protein	Protein	NNP
cord-300194-nsp53lv6	178	2	Blast	Blast	NNP
cord-300194-nsp53lv6	178	3	was	be	VBD
cord-300194-nsp53lv6	178	4	used	use	VBN
cord-300194-nsp53lv6	178	5	to	to	TO
cord-300194-nsp53lv6	178	6	search	search	VB
cord-300194-nsp53lv6	178	7	similar	similar	JJ
cord-300194-nsp53lv6	178	8	sequences	sequence	NNS
cord-300194-nsp53lv6	178	9	in	in	IN
cord-300194-nsp53lv6	178	10	the	the	DT
cord-300194-nsp53lv6	178	11	human	human	JJ
cord-300194-nsp53lv6	178	12	proteome	proteome	NN
cord-300194-nsp53lv6	178	13	.	.	.
cord-300194-nsp53lv6	179	1	The	the	DT
cord-300194-nsp53lv6	179	2	Blast	blast	NN
cord-300194-nsp53lv6	179	3	Tree	tree	NN
cord-300194-nsp53lv6	179	4	View	View	NNP
cord-300194-nsp53lv6	179	5	widget	widget	NN
cord-300194-nsp53lv6	179	6	helped	help	VBD
cord-300194-nsp53lv6	179	7	us	-PRON-	PRP
cord-300194-nsp53lv6	179	8	generate	generate	VB
cord-300194-nsp53lv6	179	9	the	the	DT
cord-300194-nsp53lv6	179	10	phylogenetic	phylogenetic	JJ
cord-300194-nsp53lv6	179	11	tree	tree	NN
cord-300194-nsp53lv6	179	12	which	which	WDT
cord-300194-nsp53lv6	179	13	is	be	VBZ
cord-300194-nsp53lv6	179	14	a	a	DT
cord-300194-nsp53lv6	179	15	simple	simple	JJ
cord-300194-nsp53lv6	179	16	distance	distance	NN
cord-300194-nsp53lv6	179	17	based	base	VBN
cord-300194-nsp53lv6	179	18	clustering	clustering	NN
cord-300194-nsp53lv6	179	19	of	of	IN
cord-300194-nsp53lv6	179	20	the	the	DT
cord-300194-nsp53lv6	179	21	sequences	sequence	NNS
cord-300194-nsp53lv6	179	22	based	base	VBN
cord-300194-nsp53lv6	179	23	on	on	IN
cord-300194-nsp53lv6	179	24	pairwise	pairwise	JJ
cord-300194-nsp53lv6	179	25	alignment	alignment	NN
cord-300194-nsp53lv6	179	26	results	result	NNS
cord-300194-nsp53lv6	179	27	of	of	IN
cord-300194-nsp53lv6	179	28	Blast	blast	NN
cord-300194-nsp53lv6	179	29	relative	relative	JJ
cord-300194-nsp53lv6	179	30	to	to	IN
cord-300194-nsp53lv6	179	31	the	the	DT
cord-300194-nsp53lv6	179	32	query	query	NN
cord-300194-nsp53lv6	179	33	sequence	sequence	NN
cord-300194-nsp53lv6	179	34	[	[	-LRB-
cord-300194-nsp53lv6	179	35	42	42	CD
cord-300194-nsp53lv6	179	36	]	]	-RRB-
cord-300194-nsp53lv6	179	37	.	.	.
cord-300194-nsp53lv6	180	1	VMD	VMD	NNP
cord-300194-nsp53lv6	180	2	was	be	VBD
cord-300194-nsp53lv6	180	3	used	use	VBN
cord-300194-nsp53lv6	180	4	for	for	IN
cord-300194-nsp53lv6	180	5	visualization	visualization	NN
cord-300194-nsp53lv6	180	6	of	of	IN
cord-300194-nsp53lv6	180	7	results	result	NNS
cord-300194-nsp53lv6	180	8	and	and	CC
cord-300194-nsp53lv6	180	9	generation	generation	NN
cord-300194-nsp53lv6	180	10	of	of	IN
cord-300194-nsp53lv6	180	11	figures	figure	NNS
cord-300194-nsp53lv6	180	12	[	[	-LRB-
cord-300194-nsp53lv6	180	13	43	43	CD
cord-300194-nsp53lv6	180	14	]	]	-RRB-
cord-300194-nsp53lv6	180	15	.	.	.
cord-300194-nsp53lv6	181	1	Supporting	support	VBG
cord-300194-nsp53lv6	181	2	figures	figure	NNS
cord-300194-nsp53lv6	181	3	,	,	,
cord-300194-nsp53lv6	181	4	Figs	Figs	NNP
cord-300194-nsp53lv6	181	5	S1-S6	S1-S6	NNPS
cord-300194-nsp53lv6	181	6	and	and	CC
cord-300194-nsp53lv6	181	7	Table	Table	NNP
cord-300194-nsp53lv6	181	8	S1	S1	NNP
cord-300194-nsp53lv6	181	9	are	be	VBP
cord-300194-nsp53lv6	181	10	provided	provide	VBN
cord-300194-nsp53lv6	181	11	online	online	RB
cord-300194-nsp53lv6	181	12	.	.	.
cord-300194-nsp53lv6	181	13	 	 	_SP
cord-300194-nsp53lv6	182	1	A	a	DT
cord-300194-nsp53lv6	182	2	SARS	SARS	NNP
cord-300194-nsp53lv6	182	3	-	-	:
cord-300194-nsp53lv6	182	4	CoV-21	CoV-21	NNP
cord-300194-nsp53lv6	182	5	2	2	CD
cord-300194-nsp53lv6	182	6	protein	protein	NN
cord-300194-nsp53lv6	182	7	interaction	interaction	NN
cord-300194-nsp53lv6	182	8	map	map	NN
cord-300194-nsp53lv6	182	9	reveals	reveal	VBZ
cord-300194-nsp53lv6	182	10	targets	target	NNS
cord-300194-nsp53lv6	182	11	for	for	IN
cord-300194-nsp53lv6	182	12	drug	drug	NN
cord-300194-nsp53lv6	182	13	repurposing	repurposing	NN
cord-300194-nsp53lv6	182	14	COVID-19	covid-19	CD
cord-300194-nsp53lv6	182	15	:	:	:
cord-300194-nsp53lv6	182	16	A	a	DT
cord-300194-nsp53lv6	182	17	novel	novel	JJ
cord-300194-nsp53lv6	182	18	zoonotic	zoonotic	JJ
cord-300194-nsp53lv6	182	19	disease	disease	NN
cord-300194-nsp53lv6	182	20	caused	cause	VBN
cord-300194-nsp53lv6	182	21	by	by	IN
cord-300194-nsp53lv6	182	22	a	a	DT
cord-300194-nsp53lv6	182	23	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	182	24	from	from	IN
cord-300194-nsp53lv6	182	25	hina	hina	NNP
cord-300194-nsp53lv6	182	26	:	:	:
cord-300194-nsp53lv6	182	27	hat	hat	NN
cord-300194-nsp53lv6	182	28	we	-PRON-	PRP
cord-300194-nsp53lv6	182	29	know	know	VBP
cord-300194-nsp53lv6	182	30	and	and	CC
cord-300194-nsp53lv6	182	31	what	what	WP
cord-300194-nsp53lv6	182	32	we	-PRON-	PRP
cord-300194-nsp53lv6	182	33	do	do	VBP
cord-300194-nsp53lv6	183	1	n't	n't	RB
cord-300194-nsp53lv6	183	2	i	i	PRP
cord-300194-nsp53lv6	183	3	ro	ro	NNP
cord-300194-nsp53lv6	184	1	iol	iol	NNP
cord-300194-nsp53lv6	184	2	ust	ust	NNP
cord-300194-nsp53lv6	184	3	From	from	IN
cord-300194-nsp53lv6	184	4	SARS	SARS	NNP
cord-300194-nsp53lv6	184	5	to	to	IN
cord-300194-nsp53lv6	184	6	MERS	MERS	NNP
cord-300194-nsp53lv6	184	7	:	:	:
cord-300194-nsp53lv6	185	1	evidence	evidence	NN
cord-300194-nsp53lv6	185	2	and	and	CC
cord-300194-nsp53lv6	185	3	speculation	speculation	NN
cord-300194-nsp53lv6	185	4	Genetic	Genetic	NNP
cord-300194-nsp53lv6	185	5	Recombination	Recombination	NNP
cord-300194-nsp53lv6	185	6	,	,	,
cord-300194-nsp53lv6	185	7	and	and	CC
cord-300194-nsp53lv6	185	8	Pathogenesis	Pathogenesis	NNP
cord-300194-nsp53lv6	185	9	of	of	IN
cord-300194-nsp53lv6	185	10	Coronaviruses	Coronaviruses	NNP
cord-300194-nsp53lv6	186	1	The	the	DT
cord-300194-nsp53lv6	186	2	effects	effect	NNS
cord-300194-nsp53lv6	186	3	of	of	IN
cord-300194-nsp53lv6	186	4	temperature	temperature	NN
cord-300194-nsp53lv6	186	5	and	and	CC
cord-300194-nsp53lv6	186	6	relative	relative	JJ
cord-300194-nsp53lv6	186	7	humidity	humidity	NN
cord-300194-nsp53lv6	186	8	on	on	IN
cord-300194-nsp53lv6	186	9	the	the	DT
cord-300194-nsp53lv6	186	10	viability	viability	NN
cord-300194-nsp53lv6	186	11	of	of	IN
cord-300194-nsp53lv6	186	12	the	the	DT
cord-300194-nsp53lv6	186	13	SARS	SARS	NNP
cord-300194-nsp53lv6	186	14	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	186	15	Stability	stability	NN
cord-300194-nsp53lv6	186	16	of	of	IN
cord-300194-nsp53lv6	186	17	SARS	SARS	NNP
cord-300194-nsp53lv6	186	18	-	-	HYPH
cord-300194-nsp53lv6	186	19	CoV-2	CoV-2	NNP
cord-300194-nsp53lv6	186	20	in	in	IN
cord-300194-nsp53lv6	186	21	different	different	JJ
cord-300194-nsp53lv6	186	22	environmental	environmental	JJ
cord-300194-nsp53lv6	186	23	conditions	condition	NNS
cord-300194-nsp53lv6	186	24	Effects	effect	NNS
cord-300194-nsp53lv6	186	25	of	of	IN
cord-300194-nsp53lv6	186	26	air	air	NN
cord-300194-nsp53lv6	186	27	temperature	temperature	NN
cord-300194-nsp53lv6	186	28	and	and	CC
cord-300194-nsp53lv6	186	29	relative	relative	JJ
cord-300194-nsp53lv6	186	30	humidity	humidity	NN
cord-300194-nsp53lv6	186	31	on	on	IN
cord-300194-nsp53lv6	186	32	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	186	33	survival	survival	NN
cord-300194-nsp53lv6	186	34	on	on	IN
cord-300194-nsp53lv6	186	35	surfaces	surface	NNS
cord-300194-nsp53lv6	186	36	Aerosol	Aerosol	NNP
cord-300194-nsp53lv6	186	37	and	and	CC
cord-300194-nsp53lv6	186	38	surface	surface	NN
cord-300194-nsp53lv6	186	39	stability	stability	NN
cord-300194-nsp53lv6	186	40	of	of	IN
cord-300194-nsp53lv6	186	41	SARS	SARS	NNP
cord-300194-nsp53lv6	186	42	-	-	HYPH
cord-300194-nsp53lv6	186	43	CoV-2	CoV-2	NNP
cord-300194-nsp53lv6	186	44	as	as	IN
cord-300194-nsp53lv6	186	45	compared	compare	VBN
cord-300194-nsp53lv6	186	46	with	with	IN
cord-300194-nsp53lv6	186	47	22	22	CD
cord-300194-nsp53lv6	186	48	SARS	SARS	NNP
cord-300194-nsp53lv6	186	49	-	-	HYPH
cord-300194-nsp53lv6	186	50	CoV-1	CoV-1	NNP
cord-300194-nsp53lv6	186	51	Influence	influence	NN
cord-300194-nsp53lv6	186	52	of	of	IN
cord-300194-nsp53lv6	186	53	meteorological	meteorological	JJ
cord-300194-nsp53lv6	186	54	factors	factor	NNS
cord-300194-nsp53lv6	186	55	and	and	CC
cord-300194-nsp53lv6	186	56	air	air	NN
cord-300194-nsp53lv6	186	57	pollution	pollution	NN
cord-300194-nsp53lv6	186	58	on	on	IN
cord-300194-nsp53lv6	186	59	the	the	DT
cord-300194-nsp53lv6	186	60	outbreak	outbreak	NN
cord-300194-nsp53lv6	186	61	of	of	IN
cord-300194-nsp53lv6	186	62	severe	severe	JJ
cord-300194-nsp53lv6	186	63	acute	acute	JJ
cord-300194-nsp53lv6	186	64	respiratory	respiratory	JJ
cord-300194-nsp53lv6	186	65	syndrome	syndrome	NN
cord-300194-nsp53lv6	187	1	An	an	DT
cord-300194-nsp53lv6	187	2	initial	initial	JJ
cord-300194-nsp53lv6	187	3	investigation	investigation	NN
cord-300194-nsp53lv6	187	4	of	of	IN
cord-300194-nsp53lv6	187	5	the	the	DT
cord-300194-nsp53lv6	187	6	association	association	NN
cord-300194-nsp53lv6	187	7	between	between	IN
cord-300194-nsp53lv6	187	8	the	the	DT
cord-300194-nsp53lv6	187	9	SARS	SARS	NNP
cord-300194-nsp53lv6	187	10	outbreak	outbreak	NN
cord-300194-nsp53lv6	187	11	and	and	CC
cord-300194-nsp53lv6	187	12	weather	weather	NN
cord-300194-nsp53lv6	187	13	:	:	:
cord-300194-nsp53lv6	187	14	With	with	IN
cord-300194-nsp53lv6	187	15	the	the	DT
cord-300194-nsp53lv6	187	16	view	view	NN
cord-300194-nsp53lv6	187	17	of	of	IN
cord-300194-nsp53lv6	187	18	the	the	DT
cord-300194-nsp53lv6	187	19	environmental	environmental	JJ
cord-300194-nsp53lv6	187	20	temperature	temperature	NN
cord-300194-nsp53lv6	187	21	and	and	CC
cord-300194-nsp53lv6	187	22	its	-PRON-	PRP$
cord-300194-nsp53lv6	187	23	variation	variation	NN
cord-300194-nsp53lv6	187	24	Temperature	temperature	NN
cord-300194-nsp53lv6	187	25	-	-	HYPH
cord-300194-nsp53lv6	187	26	dependent	dependent	JJ
cord-300194-nsp53lv6	187	27	innate	innate	JJ
cord-300194-nsp53lv6	187	28	defense	defense	NN
cord-300194-nsp53lv6	187	29	against	against	IN
cord-300194-nsp53lv6	187	30	the	the	DT
cord-300194-nsp53lv6	187	31	common	common	JJ
cord-300194-nsp53lv6	187	32	cold	cold	JJ
cord-300194-nsp53lv6	187	33	virus	virus	NN
cord-300194-nsp53lv6	187	34	limits	limit	VBZ
cord-300194-nsp53lv6	187	35	viral	viral	JJ
cord-300194-nsp53lv6	187	36	replication	replication	NN
cord-300194-nsp53lv6	187	37	at	at	IN
cord-300194-nsp53lv6	187	38	warm	warm	JJ
cord-300194-nsp53lv6	187	39	temperature	temperature	NN
cord-300194-nsp53lv6	187	40	in	in	IN
cord-300194-nsp53lv6	187	41	mouse	mouse	NN
cord-300194-nsp53lv6	187	42	airway	airway	NN
cord-300194-nsp53lv6	187	43	cells	cell	NNS
cord-300194-nsp53lv6	187	44	Roles	role	NNS
cord-300194-nsp53lv6	187	45	of	of	IN
cord-300194-nsp53lv6	187	46	Humidity	Humidity	NNP
cord-300194-nsp53lv6	187	47	and	and	CC
cord-300194-nsp53lv6	187	48	Temperature	temperature	NN
cord-300194-nsp53lv6	187	49	in	in	IN
cord-300194-nsp53lv6	187	50	Shaping	shape	VBG
cord-300194-nsp53lv6	187	51	Influenza	Influenza	NNP
cord-300194-nsp53lv6	187	52	Seasonality	Seasonality	NNP
cord-300194-nsp53lv6	187	53	Temperature	temperature	NN
cord-300194-nsp53lv6	187	54	-	-	HYPH
cord-300194-nsp53lv6	187	55	sensitive	sensitive	JJ
cord-300194-nsp53lv6	187	56	viral	viral	JJ
cord-300194-nsp53lv6	187	57	infection	infection	NN
cord-300194-nsp53lv6	187	58	:	:	:
cord-300194-nsp53lv6	187	59	Inhibition	inhibition	NN
cord-300194-nsp53lv6	187	60	of	of	IN
cord-300194-nsp53lv6	187	61	hemagglutinating	hemagglutinate	VBG
cord-300194-nsp53lv6	187	62	virus	virus	NN
cord-300194-nsp53lv6	187	63	of	of	IN
cord-300194-nsp53lv6	187	64	Japan	Japan	NNP
cord-300194-nsp53lv6	187	65	(	(	-LRB-
cord-300194-nsp53lv6	187	66	Sendai	Sendai	NNP
cord-300194-nsp53lv6	187	67	virus	virus	NN
cord-300194-nsp53lv6	187	68	)	)	-RRB-
cord-300194-nsp53lv6	187	69	infection	infection	NN
cord-300194-nsp53lv6	187	70	at	at	IN
cord-300194-nsp53lv6	187	71	41	41	CD
cord-300194-nsp53lv6	187	72	°	°	NN
cord-300194-nsp53lv6	187	73	Highly	highly	RB
cord-300194-nsp53lv6	187	74	heterogeneous	heterogeneous	JJ
cord-300194-nsp53lv6	187	75	temperature	temperature	NN
cord-300194-nsp53lv6	187	76	sensitivity	sensitivity	NN
cord-300194-nsp53lv6	187	77	of	of	IN
cord-300194-nsp53lv6	187	78	2009	2009	CD
cord-300194-nsp53lv6	187	79	pandemic	pandemic	NN
cord-300194-nsp53lv6	187	80	influenza	influenza	NN
cord-300194-nsp53lv6	187	81	A(H1N1	A(H1N1	NNP
cord-300194-nsp53lv6	187	82	)	)	-RRB-
cord-300194-nsp53lv6	188	1	viral	viral	JJ
cord-300194-nsp53lv6	188	2	isolates	isolate	NNS
cord-300194-nsp53lv6	189	1	Severe	severe	JJ
cord-300194-nsp53lv6	189	2	Acute	acute	JJ
cord-300194-nsp53lv6	189	3	Respiratory	Respiratory	NNP
cord-300194-nsp53lv6	189	4	Syndrome	Syndrome	NNP
cord-300194-nsp53lv6	189	5	Coronavirus	Coronavirus	NNP
cord-300194-nsp53lv6	189	6	2	2	CD
cord-300194-nsp53lv6	190	1	(	(	-LRB-
cord-300194-nsp53lv6	190	2	SARS	SARS	NNP
cord-300194-nsp53lv6	190	3	-	-	HYPH
cord-300194-nsp53lv6	190	4	CoV-2	CoV-2	NNP
cord-300194-nsp53lv6	190	5	)	)	-RRB-
cord-300194-nsp53lv6	190	6	:	:	:
cord-300194-nsp53lv6	191	1	An	an	DT
cord-300194-nsp53lv6	191	2	overview	overview	NN
cord-300194-nsp53lv6	191	3	of	of	IN
cord-300194-nsp53lv6	191	4	viral	viral	JJ
cord-300194-nsp53lv6	191	5	structure	structure	NN
cord-300194-nsp53lv6	191	6	and	and	CC
cord-300194-nsp53lv6	191	7	host	host	NN
cord-300194-nsp53lv6	191	8	response	response	NN
cord-300194-nsp53lv6	191	9	Structure	Structure	NNP
cord-300194-nsp53lv6	191	10	,	,	,
cord-300194-nsp53lv6	191	11	Function	Function	NNP
cord-300194-nsp53lv6	191	12	,	,	,
cord-300194-nsp53lv6	191	13	and	and	CC
cord-300194-nsp53lv6	191	14	Evolution	evolution	NN
cord-300194-nsp53lv6	191	15	of	of	IN
cord-300194-nsp53lv6	191	16	Coronavirus	Coronavirus	NNP
cord-300194-nsp53lv6	191	17	Spike	Spike	NNP
cord-300194-nsp53lv6	191	18	Proteins	Proteins	NNP
cord-300194-nsp53lv6	191	19	Structure	Structure	NNP
cord-300194-nsp53lv6	191	20	,	,	,
cord-300194-nsp53lv6	191	21	Function	Function	NNP
cord-300194-nsp53lv6	191	22	,	,	,
cord-300194-nsp53lv6	191	23	and	and	CC
cord-300194-nsp53lv6	191	24	Antigenicity	Antigenicity	NNP
cord-300194-nsp53lv6	191	25	of	of	IN
cord-300194-nsp53lv6	191	26	the	the	DT
cord-300194-nsp53lv6	191	27	SARS	SARS	NNP
cord-300194-nsp53lv6	191	28	-	-	HYPH
cord-300194-nsp53lv6	191	29	CoV-2	CoV-2	NNP
cord-300194-nsp53lv6	191	30	Spike	Spike	NNP
cord-300194-nsp53lv6	191	31	Glycoprotein	Glycoprotein	NNP
cord-300194-nsp53lv6	191	32	Activation	Activation	NNP
cord-300194-nsp53lv6	191	33	of	of	IN
cord-300194-nsp53lv6	191	34	the	the	DT
cord-300194-nsp53lv6	191	35	SARS	SARS	NNP
cord-300194-nsp53lv6	191	36	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	191	37	spike	spike	NN
cord-300194-nsp53lv6	191	38	protein	protein	NN
cord-300194-nsp53lv6	191	39	via	via	IN
cord-300194-nsp53lv6	191	40	sequential	sequential	JJ
cord-300194-nsp53lv6	191	41	proteolytic	proteolytic	JJ
cord-300194-nsp53lv6	191	42	cleavage	cleavage	NN
cord-300194-nsp53lv6	191	43	at	at	IN
cord-300194-nsp53lv6	191	44	two	two	CD
cord-300194-nsp53lv6	191	45	distinct	distinct	JJ
cord-300194-nsp53lv6	191	46	sites	site	NNS
cord-300194-nsp53lv6	191	47	Structural	structural	JJ
cord-300194-nsp53lv6	191	48	and	and	CC
cord-300194-nsp53lv6	191	49	Functional	Functional	NNP
cord-300194-nsp53lv6	191	50	Basis	Basis	NNP
cord-300194-nsp53lv6	191	51	of	of	IN
cord-300194-nsp53lv6	191	52	SARS	SARS	NNP
cord-300194-nsp53lv6	191	53	-	-	HYPH
cord-300194-nsp53lv6	191	54	CoV-2	CoV-2	NNP
cord-300194-nsp53lv6	191	55	Entry	Entry	NNP
cord-300194-nsp53lv6	191	56	by	by	IN
cord-300194-nsp53lv6	191	57	Using	use	VBG
cord-300194-nsp53lv6	191	58	Human	Human	NNP
cord-300194-nsp53lv6	191	59	ACE2	ACE2	NNP
cord-300194-nsp53lv6	191	60	Cryo	Cryo	NNP
cord-300194-nsp53lv6	191	61	-	-	HYPH
cord-300194-nsp53lv6	191	62	EM	EM	NNP
cord-300194-nsp53lv6	191	63	structures	structure	NNS
cord-300194-nsp53lv6	191	64	of	of	IN
cord-300194-nsp53lv6	191	65	MERS	MERS	NNP
cord-300194-nsp53lv6	191	66	-	-	HYPH
cord-300194-nsp53lv6	191	67	CoV	CoV	NNP
cord-300194-nsp53lv6	191	68	and	and	CC
cord-300194-nsp53lv6	191	69	SARS	SARS	NNP
cord-300194-nsp53lv6	191	70	-	-	HYPH
cord-300194-nsp53lv6	191	71	CoV	CoV	NNP
cord-300194-nsp53lv6	191	72	spike	spike	NN
cord-300194-nsp53lv6	191	73	glycoproteins	glycoprotein	NNS
cord-300194-nsp53lv6	191	74	reveal	reveal	VBP
cord-300194-nsp53lv6	191	75	the	the	DT
cord-300194-nsp53lv6	191	76	dynamic	dynamic	JJ
cord-300194-nsp53lv6	191	77	receptor	receptor	NN
cord-300194-nsp53lv6	191	78	binding	bind	VBG
cord-300194-nsp53lv6	191	79	domains	domain	NNS
cord-300194-nsp53lv6	191	80	Structure	Structure	NNP
cord-300194-nsp53lv6	191	81	of	of	IN
cord-300194-nsp53lv6	191	82	the	the	DT
cord-300194-nsp53lv6	191	83	SARS	SARS	NNP
cord-300194-nsp53lv6	191	84	-	-	HYPH
cord-300194-nsp53lv6	191	85	CoV-2	CoV-2	NNP
cord-300194-nsp53lv6	191	86	spike	spike	NN
cord-300194-nsp53lv6	191	87	receptor	receptor	NN
cord-300194-nsp53lv6	191	88	-	-	HYPH
cord-300194-nsp53lv6	191	89	binding	bind	VBG
cord-300194-nsp53lv6	191	90	domain	domain	NN
cord-300194-nsp53lv6	191	91	bound	bind	VBN
cord-300194-nsp53lv6	191	92	to	to	IN
cord-300194-nsp53lv6	191	93	the	the	DT
cord-300194-nsp53lv6	191	94	ACE2	ACE2	NNP
cord-300194-nsp53lv6	191	95	receptor	receptor	NN
cord-300194-nsp53lv6	191	96	Thermal	thermal	JJ
cord-300194-nsp53lv6	191	97	Stability	stability	NN
cord-300194-nsp53lv6	191	98	of	of	IN
cord-300194-nsp53lv6	191	99	Globins	Globins	NNP
cord-300194-nsp53lv6	191	100	:	:	:
cord-300194-nsp53lv6	191	101	Implications	implication	NNS
cord-300194-nsp53lv6	191	102	of	of	IN
cord-300194-nsp53lv6	191	103	Flexibility	Flexibility	NNP
cord-300194-nsp53lv6	191	104	and	and	CC
cord-300194-nsp53lv6	191	105	Heme	Heme	NNP
cord-300194-nsp53lv6	191	106	Coordination	Coordination	NNP
cord-300194-nsp53lv6	191	107	Studied	study	VBN
cord-300194-nsp53lv6	191	108	by	by	IN
cord-300194-nsp53lv6	191	109	Molecular	Molecular	NNP
cord-300194-nsp53lv6	191	110	Dynamics	Dynamics	NNPS
cord-300194-nsp53lv6	191	111	Simulations	Simulations	NNPS
cord-300194-nsp53lv6	191	112	Structural	structural	JJ
cord-300194-nsp53lv6	191	113	flexibility	flexibility	NN
cord-300194-nsp53lv6	191	114	and	and	CC
cord-300194-nsp53lv6	191	115	protein	protein	NN
cord-300194-nsp53lv6	191	116	adaptation	adaptation	NN
cord-300194-nsp53lv6	191	117	to	to	IN
cord-300194-nsp53lv6	191	118	temperature	temperature	NN
cord-300194-nsp53lv6	191	119	:	:	:
cord-300194-nsp53lv6	191	120	Molecular	molecular	JJ
cord-300194-nsp53lv6	191	121	dynamics	dynamic	NNS
cord-300194-nsp53lv6	191	122	analysis	analysis	NN
cord-300194-nsp53lv6	191	123	of	of	IN
cord-300194-nsp53lv6	191	124	malate	malate	NNP
cord-300194-nsp53lv6	191	125	dehydrogenases	dehydrogenases	NNP
cord-300194-nsp53lv6	191	126	of	of	IN
cord-300194-nsp53lv6	191	127	marine	marine	JJ
cord-300194-nsp53lv6	191	128	molluscs	mollusc	NNS
cord-300194-nsp53lv6	191	129	Effects	effect	NNS
cord-300194-nsp53lv6	191	130	of	of	IN
cord-300194-nsp53lv6	191	131	temperature	temperature	NN
cord-300194-nsp53lv6	191	132	and	and	CC
cord-300194-nsp53lv6	191	133	humidity	humidity	NN
cord-300194-nsp53lv6	191	134	on	on	IN
cord-300194-nsp53lv6	191	135	the	the	DT
cord-300194-nsp53lv6	191	136	daily	daily	JJ
cord-300194-nsp53lv6	191	137	new	new	JJ
cord-300194-nsp53lv6	191	138	cases	case	NNS
cord-300194-nsp53lv6	191	139	and	and	CC
cord-300194-nsp53lv6	191	140	new	new	JJ
cord-300194-nsp53lv6	191	141	deaths	death	NNS
cord-300194-nsp53lv6	191	142	of	of	IN
cord-300194-nsp53lv6	191	143	COVID-19	covid-19	CD
cord-300194-nsp53lv6	191	144	in	in	IN
cord-300194-nsp53lv6	191	145	166	166	CD
cord-300194-nsp53lv6	191	146	countries	country	NNS
cord-300194-nsp53lv6	191	147	Will	Will	MD
cord-300194-nsp53lv6	191	148	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	191	149	pandemic	pandemic	NN
cord-300194-nsp53lv6	191	150	diminish	diminish	VB
cord-300194-nsp53lv6	191	151	by	by	IN
cord-300194-nsp53lv6	191	152	summer	summer	NN
cord-300194-nsp53lv6	191	153	?	?	.
cord-300194-nsp53lv6	192	1	How	how	WRB
cord-300194-nsp53lv6	192	2	significant	significant	JJ
cord-300194-nsp53lv6	192	3	is	be	VBZ
cord-300194-nsp53lv6	192	4	a	a	DT
cord-300194-nsp53lv6	192	5	protein	protein	NN
cord-300194-nsp53lv6	192	6	structure	structure	NN
cord-300194-nsp53lv6	192	7	similarity	similarity	NN
cord-300194-nsp53lv6	192	8	with	with	IN
cord-300194-nsp53lv6	192	9	TM	TM	NNP
cord-300194-nsp53lv6	192	10	-	-	HYPH
cord-300194-nsp53lv6	192	11	score	score	NN
cord-300194-nsp53lv6	192	12	=	=	SYM
cord-300194-nsp53lv6	192	13	0.5	0.5	CD
cord-300194-nsp53lv6	192	14	?	?	.
cord-300194-nsp53lv6	193	1	The	the	DT
cord-300194-nsp53lv6	193	2	Protein	Protein	NNP
cord-300194-nsp53lv6	193	3	Data	Data	NNP
cord-300194-nsp53lv6	193	4	Bank	Bank	NNP
cord-300194-nsp53lv6	193	5	Nuc	Nuc	NNP
cord-300194-nsp53lv6	193	6	Cryo	Cryo	NNP
cord-300194-nsp53lv6	193	7	-	-	HYPH
cord-300194-nsp53lv6	193	8	electron	electron	NN
cord-300194-nsp53lv6	193	9	microscopy	microscopy	NN
cord-300194-nsp53lv6	193	10	structure	structure	NN
cord-300194-nsp53lv6	193	11	of	of	IN
cord-300194-nsp53lv6	193	12	a	a	DT
cord-300194-nsp53lv6	193	13	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	193	14	spike	spike	NN
cord-300194-nsp53lv6	193	15	glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	193	16	trimer	trimer	NN
cord-300194-nsp53lv6	193	17	Identification	identification	NN
cord-300194-nsp53lv6	193	18	of	of	IN
cord-300194-nsp53lv6	193	19	the	the	DT
cord-300194-nsp53lv6	193	20	Membrane	Membrane	NNP
cord-300194-nsp53lv6	193	21	-	-	HYPH
cord-300194-nsp53lv6	193	22	Active	active	JJ
cord-300194-nsp53lv6	193	23	Regions	Regions	NNPS
cord-300194-nsp53lv6	193	24	of	of	IN
cord-300194-nsp53lv6	193	25	the	the	DT
cord-300194-nsp53lv6	193	26	Severe	severe	JJ
cord-300194-nsp53lv6	193	27	Acute	acute	JJ
cord-300194-nsp53lv6	193	28	Respiratory	Respiratory	NNP
cord-300194-nsp53lv6	193	29	Syndrome	Syndrome	NNP
cord-300194-nsp53lv6	193	30	Coronavirus	Coronavirus	NNP
cord-300194-nsp53lv6	193	31	Spike	Spike	NNP
cord-300194-nsp53lv6	193	32	Membrane	membrane	NN
cord-300194-nsp53lv6	193	33	Glycoprotein	glycoprotein	NN
cord-300194-nsp53lv6	193	34	Using	use	VBG
cord-300194-nsp53lv6	193	35	a	a	DT
cord-300194-nsp53lv6	193	36	16/18-Mer	16/18-mer	CD
cord-300194-nsp53lv6	193	37	Peptide	peptide	NN
cord-300194-nsp53lv6	193	38	Scan	scan	NN
cord-300194-nsp53lv6	193	39	:	:	:
cord-300194-nsp53lv6	194	1	Implications	implication	NNS
cord-300194-nsp53lv6	194	2	for	for	IN
cord-300194-nsp53lv6	194	3	the	the	DT
cord-300194-nsp53lv6	194	4	Viral	Viral	NNP
cord-300194-nsp53lv6	194	5	Fusion	Fusion	NNP
cord-300194-nsp53lv6	194	6	Mechanism	Mechanism	NNP
cord-300194-nsp53lv6	194	7	J	J	NNP
cord-300194-nsp53lv6	194	8	Structure	Structure	NNP
cord-300194-nsp53lv6	194	9	of	of	IN
cord-300194-nsp53lv6	194	10	mouse	mouse	NN
cord-300194-nsp53lv6	194	11	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	194	12	spike	spike	NN
cord-300194-nsp53lv6	194	13	protein	protein	NN
cord-300194-nsp53lv6	194	14	complexed	complexe	VBN
cord-300194-nsp53lv6	194	15	with	with	IN
cord-300194-nsp53lv6	194	16	receptor	receptor	NN
cord-300194-nsp53lv6	194	17	reveals	reveal	VBZ
cord-300194-nsp53lv6	194	18	mechanism	mechanism	NN
cord-300194-nsp53lv6	194	19	for	for	IN
cord-300194-nsp53lv6	194	20	viral	viral	JJ
cord-300194-nsp53lv6	194	21	entry	entry	NN
cord-300194-nsp53lv6	194	22	Purified	purify	VBN
cord-300194-nsp53lv6	194	23	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	194	24	spike	spike	NN
cord-300194-nsp53lv6	194	25	protein	protein	NN
cord-300194-nsp53lv6	194	26	nanoparticles	nanoparticle	NNS
cord-300194-nsp53lv6	194	27	induce	induce	VBP
cord-300194-nsp53lv6	194	28	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	194	29	neutralizing	neutralize	VBG
cord-300194-nsp53lv6	194	30	antibodies	antibody	NNS
cord-300194-nsp53lv6	194	31	in	in	IN
cord-300194-nsp53lv6	194	32	mice	mouse	NNS
cord-300194-nsp53lv6	195	1	The	the	DT
cord-300194-nsp53lv6	195	2	recombinant	recombinant	JJ
cord-300194-nsp53lv6	195	3	N	n	CD
cord-300194-nsp53lv6	195	4	-	-	HYPH
cord-300194-nsp53lv6	195	5	terminal	terminal	NN
cord-300194-nsp53lv6	195	6	domain	domain	NN
cord-300194-nsp53lv6	195	7	of	of	IN
cord-300194-nsp53lv6	195	8	spike	spike	NN
cord-300194-nsp53lv6	195	9	proteins	protein	NNS
cord-300194-nsp53lv6	195	10	is	be	VBZ
cord-300194-nsp53lv6	195	11	a	a	DT
cord-300194-nsp53lv6	195	12	potential	potential	JJ
cord-300194-nsp53lv6	195	13	vaccine	vaccine	NN
cord-300194-nsp53lv6	195	14	against	against	IN
cord-300194-nsp53lv6	195	15	Middle	Middle	NNP
cord-300194-nsp53lv6	195	16	East	East	NNP
cord-300194-nsp53lv6	195	17	respiratory	respiratory	JJ
cord-300194-nsp53lv6	195	18	syndrome	syndrome	NN
cord-300194-nsp53lv6	195	19	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	195	20	(	(	-LRB-
cord-300194-nsp53lv6	195	21	MERS	MERS	NNP
cord-300194-nsp53lv6	195	22	-	-	HYPH
cord-300194-nsp53lv6	195	23	CoV	CoV	NNP
cord-300194-nsp53lv6	195	24	)	)	-RRB-
cord-300194-nsp53lv6	195	25	infection	infection	NN
cord-300194-nsp53lv6	195	26	Immunogenicity	Immunogenicity	NNP
cord-300194-nsp53lv6	195	27	and	and	CC
cord-300194-nsp53lv6	195	28	protection	protection	NN
cord-300194-nsp53lv6	195	29	efficacy	efficacy	NN
cord-300194-nsp53lv6	195	30	of	of	IN
cord-300194-nsp53lv6	195	31	monomeric	monomeric	JJ
cord-300194-nsp53lv6	195	32	and	and	CC
cord-300194-nsp53lv6	195	33	trimeric	trimeric	JJ
cord-300194-nsp53lv6	195	34	recombinant	recombinant	JJ
cord-300194-nsp53lv6	195	35	SARS	SARS	NNP
cord-300194-nsp53lv6	195	36	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	195	37	spike	spike	NN
cord-300194-nsp53lv6	195	38	protein	protein	NN
cord-300194-nsp53lv6	195	39	subunit	subunit	NN
cord-300194-nsp53lv6	195	40	vaccine	vaccine	NN
cord-300194-nsp53lv6	195	41	candidates	candidate	NNS
cord-300194-nsp53lv6	196	1	COVID-19	COVID-19	NNP
cord-300194-nsp53lv6	196	2	and	and	CC
cord-300194-nsp53lv6	196	3	Multiorgan	Multiorgan	NNP
cord-300194-nsp53lv6	196	4	Response	Response	NNP
cord-300194-nsp53lv6	196	5	Receptor	Receptor	NNP
cord-300194-nsp53lv6	196	6	-	-	HYPH
cord-300194-nsp53lv6	196	7	binding	bind	VBG
cord-300194-nsp53lv6	196	8	domain	domain	NN
cord-300194-nsp53lv6	196	9	of	of	IN
cord-300194-nsp53lv6	196	10	SARS	SARS	NNP
cord-300194-nsp53lv6	196	11	-	-	HYPH
cord-300194-nsp53lv6	196	12	CoV	CoV	NNP
cord-300194-nsp53lv6	196	13	spike	spike	NN
cord-300194-nsp53lv6	196	14	protein	protein	NN
cord-300194-nsp53lv6	196	15	induces	induce	VBZ
cord-300194-nsp53lv6	196	16	highly	highly	RB
cord-300194-nsp53lv6	196	17	potent	potent	JJ
cord-300194-nsp53lv6	196	18	neutralizing	neutralize	VBG
cord-300194-nsp53lv6	196	19	antibodies	antibody	NNS
cord-300194-nsp53lv6	196	20	:	:	:
cord-300194-nsp53lv6	196	21	Implication	implication	NN
cord-300194-nsp53lv6	196	22	for	for	IN
cord-300194-nsp53lv6	196	23	26	26	CD
cord-300194-nsp53lv6	196	24	developing	develop	VBG
cord-300194-nsp53lv6	196	25	subunit	subunit	NN
cord-300194-nsp53lv6	196	26	vaccine	vaccine	NN
cord-300194-nsp53lv6	196	27	Characterization	characterization	NN
cord-300194-nsp53lv6	196	28	of	of	IN
cord-300194-nsp53lv6	196	29	the	the	DT
cord-300194-nsp53lv6	196	30	receptor	receptor	NN
cord-300194-nsp53lv6	196	31	-	-	HYPH
cord-300194-nsp53lv6	196	32	binding	bind	VBG
cord-300194-nsp53lv6	196	33	domain	domain	NN
cord-300194-nsp53lv6	196	34	(	(	-LRB-
cord-300194-nsp53lv6	196	35	RBD	RBD	NNP
cord-300194-nsp53lv6	196	36	)	)	-RRB-
cord-300194-nsp53lv6	196	37	of	of	IN
cord-300194-nsp53lv6	196	38	2019	2019	CD
cord-300194-nsp53lv6	196	39	novel	novel	JJ
cord-300194-nsp53lv6	196	40	coronavirus	coronavirus	NN
cord-300194-nsp53lv6	196	41	:	:	:
cord-300194-nsp53lv6	196	42	implication	implication	NN
cord-300194-nsp53lv6	196	43	for	for	IN
cord-300194-nsp53lv6	196	44	development	development	NN
cord-300194-nsp53lv6	196	45	of	of	IN
cord-300194-nsp53lv6	196	46	RBD	RBD	NNP
cord-300194-nsp53lv6	196	47	protein	protein	NN
cord-300194-nsp53lv6	196	48	as	as	IN
cord-300194-nsp53lv6	196	49	a	a	DT
cord-300194-nsp53lv6	196	50	viral	viral	JJ
cord-300194-nsp53lv6	196	51	attachment	attachment	NN
cord-300194-nsp53lv6	196	52	inhibitor	inhibitor	NN
cord-300194-nsp53lv6	196	53	and	and	CC
cord-300194-nsp53lv6	196	54	vaccine	vaccine	NN
cord-300194-nsp53lv6	196	55	Structure	Structure	NNP
cord-300194-nsp53lv6	196	56	,	,	,
cord-300194-nsp53lv6	196	57	Function	Function	NNP
cord-300194-nsp53lv6	196	58	,	,	,
cord-300194-nsp53lv6	196	59	and	and	CC
cord-300194-nsp53lv6	196	60	Evolution	evolution	NN
cord-300194-nsp53lv6	196	61	of	of	IN
cord-300194-nsp53lv6	196	62	Coronavirus	Coronavirus	NNP
cord-300194-nsp53lv6	196	63	Spike	Spike	NNP
cord-300194-nsp53lv6	196	64	Proteins	Proteins	NNP
cord-300194-nsp53lv6	196	65	Receptor	Receptor	NNP
cord-300194-nsp53lv6	196	66	Recognition	Recognition	NNP
cord-300194-nsp53lv6	196	67	Mechanisms	Mechanisms	NNPS
cord-300194-nsp53lv6	196	68	of	of	IN
cord-300194-nsp53lv6	196	69	Coronaviruses	Coronaviruses	NNPS
cord-300194-nsp53lv6	196	70	:	:	:
cord-300194-nsp53lv6	197	1	a	a	DT
cord-300194-nsp53lv6	197	2	Decade	decade	NN
cord-300194-nsp53lv6	197	3	of	of	IN
cord-300194-nsp53lv6	197	4	Structural	Structural	NNP
cord-300194-nsp53lv6	197	5	Studies	Studies	NNPS
cord-300194-nsp53lv6	197	6	GROMACS	GROMACS	NNP
cord-300194-nsp53lv6	197	7	development	development	NN
cord-300194-nsp53lv6	197	8	team	team	NN
cord-300194-nsp53lv6	197	9	Improved	improve	VBD
cord-300194-nsp53lv6	197	10	side	side	NN
cord-300194-nsp53lv6	197	11	-	-	HYPH
cord-300194-nsp53lv6	197	12	chain	chain	NN
cord-300194-nsp53lv6	197	13	torsion	torsion	NN
cord-300194-nsp53lv6	197	14	potentials	potential	NNS
cord-300194-nsp53lv6	197	15	for	for	IN
cord-300194-nsp53lv6	197	16	the	the	DT
cord-300194-nsp53lv6	197	17	Amber	Amber	NNP
cord-300194-nsp53lv6	197	18	ff99SB	ff99SB	NNP
cord-300194-nsp53lv6	197	19	protein	protein	NN
cord-300194-nsp53lv6	197	20	force	force	NN
cord-300194-nsp53lv6	197	21	field	field	NN
cord-300194-nsp53lv6	197	22	Database	database	NN
cord-300194-nsp53lv6	197	23	resources	resource	NNS
cord-300194-nsp53lv6	197	24	of	of	IN
cord-300194-nsp53lv6	197	25	the	the	DT
cord-300194-nsp53lv6	197	26	National	National	NNP
cord-300194-nsp53lv6	197	27	Center	Center	NNP
cord-300194-nsp53lv6	197	28	for	for	IN
cord-300194-nsp53lv6	197	29	Biotechnology	Biotechnology	NNP
cord-300194-nsp53lv6	197	30	Information	Information	NNP