id sid tid token lemma pos cord-295545-ruxz77i8 1 1 key key JJ cord-295545-ruxz77i8 1 2 : : : cord-295545-ruxz77i8 1 3 cord-295545-ruxz77i8 cord-295545-ruxz77i8 CD cord-295545-ruxz77i8 1 4 authors author NNS cord-295545-ruxz77i8 1 5 : : : cord-295545-ruxz77i8 1 6 Hennighausen Hennighausen NNP cord-295545-ruxz77i8 1 7 , , , cord-295545-ruxz77i8 1 8 Lothar Lothar NNP cord-295545-ruxz77i8 1 9 ; ; : cord-295545-ruxz77i8 1 10 Lee Lee NNP cord-295545-ruxz77i8 1 11 , , , cord-295545-ruxz77i8 1 12 Hye Hye NNP cord-295545-ruxz77i8 1 13 Kyung Kyung NNP cord-295545-ruxz77i8 1 14 title title NN cord-295545-ruxz77i8 1 15 : : : cord-295545-ruxz77i8 1 16 Activation activation NN cord-295545-ruxz77i8 1 17 of of IN cord-295545-ruxz77i8 1 18 the the DT cord-295545-ruxz77i8 1 19 SARS SARS NNP cord-295545-ruxz77i8 1 20 - - HYPH cord-295545-ruxz77i8 1 21 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 1 22 receptor receptor NN cord-295545-ruxz77i8 1 23 Ace2 Ace2 NNP cord-295545-ruxz77i8 1 24 by by IN cord-295545-ruxz77i8 1 25 cytokines cytokine NNS cord-295545-ruxz77i8 1 26 through through IN cord-295545-ruxz77i8 1 27 pan pan JJ cord-295545-ruxz77i8 1 28 JAK JAK NNP cord-295545-ruxz77i8 1 29 - - HYPH cord-295545-ruxz77i8 1 30 STAT stat NN cord-295545-ruxz77i8 1 31 enhancers enhancer NNS cord-295545-ruxz77i8 1 32 date date NN cord-295545-ruxz77i8 1 33 : : : cord-295545-ruxz77i8 1 34 2020 2020 CD cord-295545-ruxz77i8 1 35 - - HYPH cord-295545-ruxz77i8 1 36 05 05 CD cord-295545-ruxz77i8 1 37 - - HYPH cord-295545-ruxz77i8 1 38 11 11 CD cord-295545-ruxz77i8 1 39 journal journal NN cord-295545-ruxz77i8 1 40 : : : cord-295545-ruxz77i8 2 1 bioRxiv biorxiv IN cord-295545-ruxz77i8 2 2 DOI DOI NNP cord-295545-ruxz77i8 2 3 : : : cord-295545-ruxz77i8 3 1 10.1101/2020.05.11.089045 10.1101/2020.05.11.089045 LS cord-295545-ruxz77i8 3 2 sha sha NNP cord-295545-ruxz77i8 3 3 : : : cord-295545-ruxz77i8 3 4 5faebf10727332cc9f91a323e702e58efb744d75 5faebf10727332cc9f91a323e702e58efb744d75 CD cord-295545-ruxz77i8 3 5 doc_id doc_id CD cord-295545-ruxz77i8 3 6 : : : cord-295545-ruxz77i8 3 7 295545 295545 CD cord-295545-ruxz77i8 3 8 cord_uid cord_uid NNS cord-295545-ruxz77i8 3 9 : : : cord-295545-ruxz77i8 3 10 ruxz77i8 ruxz77i8 NNP cord-295545-ruxz77i8 3 11 ACE2 ACE2 NNP cord-295545-ruxz77i8 3 12 , , , cord-295545-ruxz77i8 3 13 in in IN cord-295545-ruxz77i8 3 14 concert concert NN cord-295545-ruxz77i8 3 15 with with IN cord-295545-ruxz77i8 3 16 the the DT cord-295545-ruxz77i8 3 17 protease protease NN cord-295545-ruxz77i8 3 18 TMPRSS2 TMPRSS2 NNP cord-295545-ruxz77i8 3 19 , , , cord-295545-ruxz77i8 3 20 binds bind VBZ cord-295545-ruxz77i8 3 21 the the DT cord-295545-ruxz77i8 3 22 novel novel JJ cord-295545-ruxz77i8 3 23 coronavirus coronavirus NN cord-295545-ruxz77i8 3 24 SARS SARS NNP cord-295545-ruxz77i8 3 25 - - HYPH cord-295545-ruxz77i8 3 26 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 3 27 and and CC cord-295545-ruxz77i8 3 28 facilitates facilitate VBZ cord-295545-ruxz77i8 3 29 its -PRON- PRP$ cord-295545-ruxz77i8 3 30 cellular cellular JJ cord-295545-ruxz77i8 3 31 entry entry NN cord-295545-ruxz77i8 3 32 . . . cord-295545-ruxz77i8 4 1 The the DT cord-295545-ruxz77i8 4 2 ACE2 ACE2 NNP cord-295545-ruxz77i8 4 3 gene gene NN cord-295545-ruxz77i8 4 4 is be VBZ cord-295545-ruxz77i8 4 5 expressed express VBN cord-295545-ruxz77i8 4 6 in in IN cord-295545-ruxz77i8 4 7 SARS SARS NNP cord-295545-ruxz77i8 4 8 - - HYPH cord-295545-ruxz77i8 4 9 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 4 10 target target NN cord-295545-ruxz77i8 4 11 cells cell NNS cord-295545-ruxz77i8 4 12 , , , cord-295545-ruxz77i8 4 13 including include VBG cord-295545-ruxz77i8 4 14 Type Type NNP cord-295545-ruxz77i8 4 15 II II NNP cord-295545-ruxz77i8 4 16 Pneumocytes Pneumocytes NNPS cord-295545-ruxz77i8 4 17 ( ( -LRB- cord-295545-ruxz77i8 4 18 Ziegler Ziegler NNP cord-295545-ruxz77i8 4 19 , , , cord-295545-ruxz77i8 4 20 2020 2020 CD cord-295545-ruxz77i8 4 21 ) ) -RRB- cord-295545-ruxz77i8 4 22 , , , cord-295545-ruxz77i8 4 23 and and CC cord-295545-ruxz77i8 4 24 is be VBZ cord-295545-ruxz77i8 4 25 activated activate VBN cord-295545-ruxz77i8 4 26 by by IN cord-295545-ruxz77i8 4 27 interferons interferon NNS cord-295545-ruxz77i8 4 28 . . . cord-295545-ruxz77i8 5 1 Viral Viral NNP cord-295545-ruxz77i8 5 2 RNA RNA NNP cord-295545-ruxz77i8 5 3 was be VBD cord-295545-ruxz77i8 5 4 also also RB cord-295545-ruxz77i8 5 5 detected detect VBN cord-295545-ruxz77i8 5 6 in in IN cord-295545-ruxz77i8 5 7 breast breast NN cord-295545-ruxz77i8 5 8 milk milk NN cord-295545-ruxz77i8 6 1 ( ( -LRB- cord-295545-ruxz77i8 6 2 Wu Wu NNP cord-295545-ruxz77i8 6 3 et et NNP cord-295545-ruxz77i8 6 4 al al NNP cord-295545-ruxz77i8 6 5 . . NNP cord-295545-ruxz77i8 6 6 , , , cord-295545-ruxz77i8 6 7 2020 2020 CD cord-295545-ruxz77i8 6 8 ) ) -RRB- cord-295545-ruxz77i8 6 9 , , , cord-295545-ruxz77i8 6 10 raising raise VBG cord-295545-ruxz77i8 6 11 the the DT cord-295545-ruxz77i8 6 12 possibility possibility NN cord-295545-ruxz77i8 6 13 that that IN cord-295545-ruxz77i8 6 14 ACE2 ACE2 NNP cord-295545-ruxz77i8 6 15 expression expression NN cord-295545-ruxz77i8 6 16 is be VBZ cord-295545-ruxz77i8 6 17 under under IN cord-295545-ruxz77i8 6 18 the the DT cord-295545-ruxz77i8 6 19 control control NN cord-295545-ruxz77i8 6 20 of of IN cord-295545-ruxz77i8 6 21 cytokines cytokine NNS cord-295545-ruxz77i8 6 22 through through IN cord-295545-ruxz77i8 6 23 the the DT cord-295545-ruxz77i8 6 24 JAK JAK NNP cord-295545-ruxz77i8 6 25 - - HYPH cord-295545-ruxz77i8 6 26 STAT STAT NNP cord-295545-ruxz77i8 6 27 pathway pathway NN cord-295545-ruxz77i8 6 28 . . . cord-295545-ruxz77i8 7 1 Here here RB cord-295545-ruxz77i8 7 2 we -PRON- PRP cord-295545-ruxz77i8 7 3 show show VBP cord-295545-ruxz77i8 7 4 that that IN cord-295545-ruxz77i8 7 5 Ace2 Ace2 NNP cord-295545-ruxz77i8 7 6 expression expression NN cord-295545-ruxz77i8 7 7 in in IN cord-295545-ruxz77i8 7 8 mammary mammary JJ cord-295545-ruxz77i8 7 9 tissue tissue NN cord-295545-ruxz77i8 7 10 is be VBZ cord-295545-ruxz77i8 7 11 induced induce VBN cord-295545-ruxz77i8 7 12 during during IN cord-295545-ruxz77i8 7 13 pregnancy pregnancy NN cord-295545-ruxz77i8 7 14 and and CC cord-295545-ruxz77i8 7 15 lactation lactation NN cord-295545-ruxz77i8 7 16 , , , cord-295545-ruxz77i8 7 17 which which WDT cord-295545-ruxz77i8 7 18 coincides coincide VBZ cord-295545-ruxz77i8 7 19 with with IN cord-295545-ruxz77i8 7 20 the the DT cord-295545-ruxz77i8 7 21 establishment establishment NN cord-295545-ruxz77i8 7 22 of of IN cord-295545-ruxz77i8 7 23 a a DT cord-295545-ruxz77i8 7 24 candidate candidate NN cord-295545-ruxz77i8 7 25 enhancer enhancer NN cord-295545-ruxz77i8 7 26 . . . cord-295545-ruxz77i8 8 1 The the DT cord-295545-ruxz77i8 8 2 prolactin prolactin NN cord-295545-ruxz77i8 8 3 - - HYPH cord-295545-ruxz77i8 8 4 activated activate VBN cord-295545-ruxz77i8 8 5 transcription transcription NN cord-295545-ruxz77i8 8 6 factor factor NN cord-295545-ruxz77i8 8 7 STAT5 stat5 RB cord-295545-ruxz77i8 8 8 binds bind VBZ cord-295545-ruxz77i8 8 9 to to TO cord-295545-ruxz77i8 8 10 tandem tandem VB cord-295545-ruxz77i8 8 11 sites site NNS cord-295545-ruxz77i8 8 12 that that WDT cord-295545-ruxz77i8 8 13 coincide coincide VBP cord-295545-ruxz77i8 8 14 with with IN cord-295545-ruxz77i8 8 15 activating activate VBG cord-295545-ruxz77i8 8 16 histone histone NN cord-295545-ruxz77i8 8 17 enhancer enhancer NN cord-295545-ruxz77i8 8 18 marks mark NNS cord-295545-ruxz77i8 8 19 and and CC cord-295545-ruxz77i8 8 20 additional additional JJ cord-295545-ruxz77i8 8 21 transcription transcription NN cord-295545-ruxz77i8 8 22 components component NNS cord-295545-ruxz77i8 8 23 . . . cord-295545-ruxz77i8 9 1 The the DT cord-295545-ruxz77i8 9 2 presence presence NN cord-295545-ruxz77i8 9 3 of of IN cord-295545-ruxz77i8 9 4 pan pan NNP cord-295545-ruxz77i8 9 5 JAK JAK NNP cord-295545-ruxz77i8 9 6 - - HYPH cord-295545-ruxz77i8 9 7 STAT stat NN cord-295545-ruxz77i8 9 8 components component NNS cord-295545-ruxz77i8 9 9 in in IN cord-295545-ruxz77i8 9 10 mammary mammary JJ cord-295545-ruxz77i8 9 11 alveolar alveolar NN cord-295545-ruxz77i8 9 12 cells cell NNS cord-295545-ruxz77i8 9 13 and and CC cord-295545-ruxz77i8 9 14 in in IN cord-295545-ruxz77i8 9 15 Type Type NNP cord-295545-ruxz77i8 9 16 II II NNP cord-295545-ruxz77i8 9 17 Pneumocytes Pneumocytes NNPS cord-295545-ruxz77i8 9 18 combined combine VBN cord-295545-ruxz77i8 9 19 with with IN cord-295545-ruxz77i8 9 20 the the DT cord-295545-ruxz77i8 9 21 autoregulation autoregulation NN cord-295545-ruxz77i8 9 22 of of IN cord-295545-ruxz77i8 9 23 both both DT cord-295545-ruxz77i8 9 24 STAT1 stat1 XX cord-295545-ruxz77i8 10 1 and and CC cord-295545-ruxz77i8 10 2 STAT5 STAT5 NNP cord-295545-ruxz77i8 10 3 suggests suggest VBZ cord-295545-ruxz77i8 10 4 a a DT cord-295545-ruxz77i8 10 5 prominent prominent JJ cord-295545-ruxz77i8 10 6 role role NN cord-295545-ruxz77i8 10 7 of of IN cord-295545-ruxz77i8 10 8 cytokine cytokine NN cord-295545-ruxz77i8 10 9 signaling signal VBG cord-295545-ruxz77i8 10 10 pathways pathway NNS cord-295545-ruxz77i8 10 11 in in IN cord-295545-ruxz77i8 10 12 cells cell NNS cord-295545-ruxz77i8 10 13 targeted target VBN cord-295545-ruxz77i8 10 14 by by IN cord-295545-ruxz77i8 10 15 SARS SARS NNP cord-295545-ruxz77i8 10 16 - - HYPH cord-295545-ruxz77i8 10 17 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 10 18 . . . cord-295545-ruxz77i8 11 1 ACE2 ACE2 NNP cord-295545-ruxz77i8 11 2 , , , cord-295545-ruxz77i8 11 3 the the DT cord-295545-ruxz77i8 11 4 receptor receptor NN cord-295545-ruxz77i8 11 5 for for IN cord-295545-ruxz77i8 11 6 SARS SARS NNP cord-295545-ruxz77i8 11 7 - - HYPH cord-295545-ruxz77i8 11 8 CoV CoV NNP cord-295545-ruxz77i8 11 9 ( ( -LRB- cord-295545-ruxz77i8 11 10 Imai Imai NNP cord-295545-ruxz77i8 11 11 et et NNP cord-295545-ruxz77i8 11 12 al al NNP cord-295545-ruxz77i8 11 13 . . NNP cord-295545-ruxz77i8 11 14 , , , cord-295545-ruxz77i8 11 15 2005 2005 CD cord-295545-ruxz77i8 11 16 ) ) -RRB- cord-295545-ruxz77i8 11 17 and and CC cord-295545-ruxz77i8 11 18 SARS SARS NNP cord-295545-ruxz77i8 11 19 - - HYPH cord-295545-ruxz77i8 11 20 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 12 1 ( ( -LRB- cord-295545-ruxz77i8 12 2 Hoffmann Hoffmann NNP cord-295545-ruxz77i8 12 3 et et NNP cord-295545-ruxz77i8 12 4 al al NNP cord-295545-ruxz77i8 12 5 . . NNP cord-295545-ruxz77i8 12 6 , , , cord-295545-ruxz77i8 12 7 2020 2020 CD cord-295545-ruxz77i8 12 8 ) ) -RRB- cord-295545-ruxz77i8 12 9 , , , cord-295545-ruxz77i8 12 10 has have VBZ cord-295545-ruxz77i8 12 11 been be VBN cord-295545-ruxz77i8 12 12 identified identify VBN cord-295545-ruxz77i8 12 13 in in IN cord-295545-ruxz77i8 12 14 several several JJ cord-295545-ruxz77i8 12 15 target target NN cord-295545-ruxz77i8 12 16 cells cell NNS cord-295545-ruxz77i8 12 17 , , , cord-295545-ruxz77i8 12 18 including include VBG cord-295545-ruxz77i8 12 19 absorptive absorptive JJ cord-295545-ruxz77i8 12 20 Enterocytes Enterocytes NNPS cord-295545-ruxz77i8 12 21 ( ( -LRB- cord-295545-ruxz77i8 12 22 Lamers Lamers NNPS cord-295545-ruxz77i8 12 23 et et NNP cord-295545-ruxz77i8 12 24 al al NNP cord-295545-ruxz77i8 12 25 . . NNP cord-295545-ruxz77i8 12 26 , , , cord-295545-ruxz77i8 12 27 2020 2020 CD cord-295545-ruxz77i8 12 28 ) ) -RRB- cord-295545-ruxz77i8 12 29 , , , cord-295545-ruxz77i8 12 30 secretory secretory JJ cord-295545-ruxz77i8 12 31 goblet goblet NN cord-295545-ruxz77i8 12 32 cells cell NNS cord-295545-ruxz77i8 12 33 ( ( -LRB- cord-295545-ruxz77i8 12 34 Zhao Zhao NNP cord-295545-ruxz77i8 12 35 , , , cord-295545-ruxz77i8 12 36 2020 2020 CD cord-295545-ruxz77i8 12 37 ) ) -RRB- cord-295545-ruxz77i8 12 38 , , , cord-295545-ruxz77i8 12 39 the the DT cord-295545-ruxz77i8 12 40 olfactory olfactory JJ cord-295545-ruxz77i8 12 41 system system NN cord-295545-ruxz77i8 12 42 ( ( -LRB- cord-295545-ruxz77i8 12 43 Brann Brann NNP cord-295545-ruxz77i8 12 44 , , , cord-295545-ruxz77i8 12 45 2020 2020 CD cord-295545-ruxz77i8 12 46 ) ) -RRB- cord-295545-ruxz77i8 12 47 and and CC cord-295545-ruxz77i8 12 48 several several JJ cord-295545-ruxz77i8 12 49 epithelial epithelial JJ cord-295545-ruxz77i8 12 50 cell cell NN cord-295545-ruxz77i8 12 51 types type NNS cord-295545-ruxz77i8 12 52 ( ( -LRB- cord-295545-ruxz77i8 12 53 Brann Brann NNP cord-295545-ruxz77i8 12 54 , , , cord-295545-ruxz77i8 12 55 2020 2020 CD cord-295545-ruxz77i8 12 56 ; ; : cord-295545-ruxz77i8 12 57 Lukassen Lukassen NNP cord-295545-ruxz77i8 12 58 et et NNP cord-295545-ruxz77i8 12 59 al al NNP cord-295545-ruxz77i8 12 60 . . NNP cord-295545-ruxz77i8 12 61 , , , cord-295545-ruxz77i8 12 62 2020 2020 CD cord-295545-ruxz77i8 12 63 ; ; . cord-295545-ruxz77i8 13 1 Qi Qi NNP cord-295545-ruxz77i8 13 2 et et NNP cord-295545-ruxz77i8 13 3 al al NNP cord-295545-ruxz77i8 13 4 . . NNP cord-295545-ruxz77i8 13 5 , , , cord-295545-ruxz77i8 13 6 2020 2020 CD cord-295545-ruxz77i8 13 7 ) ) -RRB- cord-295545-ruxz77i8 13 8 . . . cord-295545-ruxz77i8 14 1 A a DT cord-295545-ruxz77i8 14 2 study study NN cord-295545-ruxz77i8 14 3 in in IN cord-295545-ruxz77i8 14 4 pneumocytes pneumocyte NNS cord-295545-ruxz77i8 14 5 demonstrated demonstrate VBD cord-295545-ruxz77i8 14 6 that that IN cord-295545-ruxz77i8 14 7 ACE2 ACE2 NNP cord-295545-ruxz77i8 14 8 expression expression NN cord-295545-ruxz77i8 14 9 is be VBZ cord-295545-ruxz77i8 14 10 induced induce VBN cord-295545-ruxz77i8 14 11 by by IN cord-295545-ruxz77i8 14 12 interferons interferon NNS cord-295545-ruxz77i8 14 13 ( ( -LRB- cord-295545-ruxz77i8 14 14 Ziegler Ziegler NNP cord-295545-ruxz77i8 14 15 , , , cord-295545-ruxz77i8 14 16 2020 2020 CD cord-295545-ruxz77i8 14 17 ) ) -RRB- cord-295545-ruxz77i8 14 18 , , , cord-295545-ruxz77i8 14 19 possibly possibly RB cord-295545-ruxz77i8 14 20 through through IN cord-295545-ruxz77i8 14 21 the the DT cord-295545-ruxz77i8 14 22 transcription transcription NN cord-295545-ruxz77i8 14 23 factors factor NNS cord-295545-ruxz77i8 14 24 Signal Signal NNP cord-295545-ruxz77i8 14 25 Transducer Transducer NNP cord-295545-ruxz77i8 14 26 and and CC cord-295545-ruxz77i8 14 27 Activator Activator NNP cord-295545-ruxz77i8 14 28 of of IN cord-295545-ruxz77i8 14 29 Transcription Transcription NNP cord-295545-ruxz77i8 14 30 ( ( -LRB- cord-295545-ruxz77i8 14 31 STAT stat NN cord-295545-ruxz77i8 14 32 ) ) -RRB- cord-295545-ruxz77i8 14 33 1 1 CD cord-295545-ruxz77i8 14 34 and and CC cord-295545-ruxz77i8 14 35 2 2 CD cord-295545-ruxz77i8 14 36 , , , cord-295545-ruxz77i8 14 37 as as IN cord-295545-ruxz77i8 14 38 the the DT cord-295545-ruxz77i8 14 39 authors author NNS cord-295545-ruxz77i8 14 40 suggest suggest VBP cord-295545-ruxz77i8 14 41 . . . cord-295545-ruxz77i8 15 1 The the DT cord-295545-ruxz77i8 15 2 STAT stat NN cord-295545-ruxz77i8 15 3 family family NN cord-295545-ruxz77i8 15 4 is be VBZ cord-295545-ruxz77i8 15 5 comprised comprise VBN cord-295545-ruxz77i8 15 6 of of IN cord-295545-ruxz77i8 15 7 seven seven CD cord-295545-ruxz77i8 15 8 transcription transcription NN cord-295545-ruxz77i8 15 9 factors factor NNS cord-295545-ruxz77i8 15 10 ( ( -LRB- cord-295545-ruxz77i8 15 11 STAT1 stat1 XX cord-295545-ruxz77i8 15 12 , , , cord-295545-ruxz77i8 15 13 2 2 CD cord-295545-ruxz77i8 15 14 , , , cord-295545-ruxz77i8 15 15 3 3 CD cord-295545-ruxz77i8 15 16 , , , cord-295545-ruxz77i8 15 17 4 4 CD cord-295545-ruxz77i8 15 18 , , , cord-295545-ruxz77i8 15 19 5A 5a CD cord-295545-ruxz77i8 15 20 , , , cord-295545-ruxz77i8 15 21 5B 5b NN cord-295545-ruxz77i8 15 22 and and CC cord-295545-ruxz77i8 15 23 6 6 CD cord-295545-ruxz77i8 15 24 ) ) -RRB- cord-295545-ruxz77i8 15 25 that that WDT cord-295545-ruxz77i8 15 26 are be VBP cord-295545-ruxz77i8 15 27 activated activate VBN cord-295545-ruxz77i8 15 28 by by IN cord-295545-ruxz77i8 15 29 type type NN cord-295545-ruxz77i8 15 30 I -PRON- PRP cord-295545-ruxz77i8 15 31 and and CC cord-295545-ruxz77i8 15 32 II II NNP cord-295545-ruxz77i8 15 33 cytokines cytokine NNS cord-295545-ruxz77i8 15 34 through through IN cord-295545-ruxz77i8 15 35 their -PRON- PRP$ cord-295545-ruxz77i8 15 36 respective respective JJ cord-295545-ruxz77i8 15 37 receptors receptor NNS cord-295545-ruxz77i8 15 38 and and CC cord-295545-ruxz77i8 15 39 the the DT cord-295545-ruxz77i8 15 40 JAK JAK NNP cord-295545-ruxz77i8 15 41 / / SYM cord-295545-ruxz77i8 15 42 TYK2 TYK2 NNP cord-295545-ruxz77i8 15 43 family family NN cord-295545-ruxz77i8 15 44 of of IN cord-295545-ruxz77i8 15 45 tyrosine tyrosine NN cord-295545-ruxz77i8 15 46 kinases kinase NNS cord-295545-ruxz77i8 15 47 ( ( -LRB- cord-295545-ruxz77i8 15 48 Stark stark JJ cord-295545-ruxz77i8 15 49 and and CC cord-295545-ruxz77i8 15 50 Darnell Darnell NNP cord-295545-ruxz77i8 15 51 , , , cord-295545-ruxz77i8 15 52 2012 2012 CD cord-295545-ruxz77i8 15 53 ) ) -RRB- cord-295545-ruxz77i8 15 54 . . . cord-295545-ruxz77i8 16 1 Although although IN cord-295545-ruxz77i8 16 2 each each DT cord-295545-ruxz77i8 16 3 cytokine cytokine NN cord-295545-ruxz77i8 16 4 receptor receptor NN cord-295545-ruxz77i8 16 5 has have VBZ cord-295545-ruxz77i8 16 6 some some DT cord-295545-ruxz77i8 16 7 preference preference NN cord-295545-ruxz77i8 16 8 for for IN cord-295545-ruxz77i8 16 9 individual individual JJ cord-295545-ruxz77i8 16 10 STAT stat NN cord-295545-ruxz77i8 16 11 members member NNS cord-295545-ruxz77i8 16 12 , , , cord-295545-ruxz77i8 16 13 it -PRON- PRP cord-295545-ruxz77i8 16 14 has have VBZ cord-295545-ruxz77i8 16 15 become become VBN cord-295545-ruxz77i8 16 16 clear clear JJ cord-295545-ruxz77i8 16 17 that that IN cord-295545-ruxz77i8 16 18 any any DT cord-295545-ruxz77i8 16 19 given give VBN cord-295545-ruxz77i8 16 20 cytokine cytokine NN cord-295545-ruxz77i8 16 21 can can MD cord-295545-ruxz77i8 16 22 activate activate VB cord-295545-ruxz77i8 16 23 several several JJ cord-295545-ruxz77i8 16 24 , , , cord-295545-ruxz77i8 16 25 if if IN cord-295545-ruxz77i8 16 26 not not RB cord-295545-ruxz77i8 16 27 all all DT cord-295545-ruxz77i8 16 28 , , , cord-295545-ruxz77i8 16 29 STAT stat NN cord-295545-ruxz77i8 16 30 members member NNS cord-295545-ruxz77i8 16 31 , , , cord-295545-ruxz77i8 16 32 which which WDT cord-295545-ruxz77i8 16 33 subsequently subsequently RB cord-295545-ruxz77i8 16 34 bind bind VBP cord-295545-ruxz77i8 16 35 to to IN cord-295545-ruxz77i8 16 36 a a DT cord-295545-ruxz77i8 16 37 shared share VBN cord-295545-ruxz77i8 16 38 DNA dna NN cord-295545-ruxz77i8 16 39 motif motif NN cord-295545-ruxz77i8 16 40 , , , cord-295545-ruxz77i8 16 41 the the DT cord-295545-ruxz77i8 16 42 gamma gamma NN cord-295545-ruxz77i8 16 43 interferon interferon NN cord-295545-ruxz77i8 16 44 activated activate VBD cord-295545-ruxz77i8 16 45 sequence sequence NN cord-295545-ruxz77i8 16 46 ( ( -LRB- cord-295545-ruxz77i8 16 47 GAS gas NN cord-295545-ruxz77i8 16 48 ) ) -RRB- cord-295545-ruxz77i8 17 1 ( ( -LRB- cord-295545-ruxz77i8 17 2 Hennighausen Hennighausen NNP cord-295545-ruxz77i8 17 3 and and CC cord-295545-ruxz77i8 17 4 Robinson Robinson NNP cord-295545-ruxz77i8 17 5 , , , cord-295545-ruxz77i8 17 6 2008 2008 CD cord-295545-ruxz77i8 17 7 ) ) -RRB- cord-295545-ruxz77i8 17 8 . . . cord-295545-ruxz77i8 18 1 This this DT cord-295545-ruxz77i8 18 2 permits permit VBZ cord-295545-ruxz77i8 18 3 individual individual JJ cord-295545-ruxz77i8 18 4 genes gene NNS cord-295545-ruxz77i8 18 5 to to TO cord-295545-ruxz77i8 18 6 be be VB cord-295545-ruxz77i8 18 7 activated activate VBN cord-295545-ruxz77i8 18 8 by by IN cord-295545-ruxz77i8 18 9 more more JJR cord-295545-ruxz77i8 18 10 than than IN cord-295545-ruxz77i8 18 11 one one CD cord-295545-ruxz77i8 18 12 cytokine cytokine NN cord-295545-ruxz77i8 18 13 through through IN cord-295545-ruxz77i8 18 14 different different JJ cord-295545-ruxz77i8 18 15 receptors receptor NNS cord-295545-ruxz77i8 18 16 and and CC cord-295545-ruxz77i8 18 17 several several JJ cord-295545-ruxz77i8 18 18 STAT stat NN cord-295545-ruxz77i8 18 19 family family NN cord-295545-ruxz77i8 18 20 members member NNS cord-295545-ruxz77i8 18 21 . . . cord-295545-ruxz77i8 19 1 While while IN cord-295545-ruxz77i8 19 2 SARS SARS NNP cord-295545-ruxz77i8 19 3 - - HYPH cord-295545-ruxz77i8 19 4 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 19 5 infection infection NN cord-295545-ruxz77i8 19 6 of of IN cord-295545-ruxz77i8 19 7 lung lung NN cord-295545-ruxz77i8 19 8 epithelium epithelium NN cord-295545-ruxz77i8 19 9 is be VBZ cord-295545-ruxz77i8 19 10 driving drive VBG cord-295545-ruxz77i8 19 11 the the DT cord-295545-ruxz77i8 19 12 disease disease NN cord-295545-ruxz77i8 19 13 , , , cord-295545-ruxz77i8 19 14 disturbances disturbance NNS cord-295545-ruxz77i8 19 15 in in IN cord-295545-ruxz77i8 19 16 other other JJ cord-295545-ruxz77i8 19 17 cell cell NN cord-295545-ruxz77i8 19 18 types type NNS cord-295545-ruxz77i8 19 19 ( ( -LRB- cord-295545-ruxz77i8 19 20 Qi Qi NNP cord-295545-ruxz77i8 19 21 et et FW cord-295545-ruxz77i8 19 22 al al NNP cord-295545-ruxz77i8 19 23 . . NNP cord-295545-ruxz77i8 19 24 , , , cord-295545-ruxz77i8 19 25 2020 2020 CD cord-295545-ruxz77i8 19 26 ) ) -RRB- cord-295545-ruxz77i8 19 27 , , , cord-295545-ruxz77i8 19 28 such such JJ cord-295545-ruxz77i8 19 29 as as IN cord-295545-ruxz77i8 19 30 the the DT cord-295545-ruxz77i8 19 31 olfactory olfactory JJ cord-295545-ruxz77i8 19 32 system system NN cord-295545-ruxz77i8 19 33 ( ( -LRB- cord-295545-ruxz77i8 19 34 Brann Brann NNP cord-295545-ruxz77i8 19 35 , , , cord-295545-ruxz77i8 19 36 2020 2020 CD cord-295545-ruxz77i8 19 37 ) ) -RRB- cord-295545-ruxz77i8 19 38 , , , cord-295545-ruxz77i8 19 39 have have VBP cord-295545-ruxz77i8 19 40 been be VBN cord-295545-ruxz77i8 19 41 observed observe VBN cord-295545-ruxz77i8 19 42 . . . cord-295545-ruxz77i8 20 1 SARS SARS NNP cord-295545-ruxz77i8 20 2 - - HYPH cord-295545-ruxz77i8 20 3 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 20 4 RNA RNA NNP cord-295545-ruxz77i8 20 5 has have VBZ cord-295545-ruxz77i8 20 6 also also RB cord-295545-ruxz77i8 20 7 been be VBN cord-295545-ruxz77i8 20 8 detected detect VBN cord-295545-ruxz77i8 20 9 in in IN cord-295545-ruxz77i8 20 10 breast breast NN cord-295545-ruxz77i8 20 11 milk milk NN cord-295545-ruxz77i8 20 12 of of IN cord-295545-ruxz77i8 20 13 infected infected JJ cord-295545-ruxz77i8 20 14 patients patient NNS cord-295545-ruxz77i8 20 15 suggesting suggest VBG cord-295545-ruxz77i8 20 16 that that IN cord-295545-ruxz77i8 20 17 the the DT cord-295545-ruxz77i8 20 18 virus virus NN cord-295545-ruxz77i8 20 19 can can MD cord-295545-ruxz77i8 20 20 enter enter VB cord-295545-ruxz77i8 20 21 differentiated differentiate VBN cord-295545-ruxz77i8 20 22 mammary mammary JJ cord-295545-ruxz77i8 20 23 alveolar alveolar NN cord-295545-ruxz77i8 20 24 cells cell NNS cord-295545-ruxz77i8 20 25 and and CC cord-295545-ruxz77i8 20 26 be be VB cord-295545-ruxz77i8 20 27 vertically vertically RB cord-295545-ruxz77i8 20 28 transmitted transmit VBN cord-295545-ruxz77i8 20 29 through through IN cord-295545-ruxz77i8 20 30 breast breast NN cord-295545-ruxz77i8 20 31 feeding feeding NN cord-295545-ruxz77i8 20 32 . . . cord-295545-ruxz77i8 21 1 Based base VBN cord-295545-ruxz77i8 21 2 on on IN cord-295545-ruxz77i8 21 3 the the DT cord-295545-ruxz77i8 21 4 overlapping overlap VBG cord-295545-ruxz77i8 21 5 activities activity NNS cord-295545-ruxz77i8 21 6 of of IN cord-295545-ruxz77i8 21 7 JAK JAK NNP cord-295545-ruxz77i8 21 8 - - HYPH cord-295545-ruxz77i8 21 9 STAT stat NN cord-295545-ruxz77i8 21 10 components component NNS cord-295545-ruxz77i8 21 11 and and CC cord-295545-ruxz77i8 21 12 their -PRON- PRP$ cord-295545-ruxz77i8 21 13 potential potential JJ cord-295545-ruxz77i8 21 14 redundancy redundancy NN cord-295545-ruxz77i8 21 15 , , , cord-295545-ruxz77i8 21 16 it -PRON- PRP cord-295545-ruxz77i8 21 17 is be VBZ cord-295545-ruxz77i8 21 18 likely likely JJ cord-295545-ruxz77i8 21 19 that that IN cord-295545-ruxz77i8 21 20 ACE2 ACE2 NNP cord-295545-ruxz77i8 21 21 expression expression NN cord-295545-ruxz77i8 21 22 is be VBZ cord-295545-ruxz77i8 21 23 activated activate VBN cord-295545-ruxz77i8 21 24 by by IN cord-295545-ruxz77i8 21 25 a a DT cord-295545-ruxz77i8 21 26 wide wide JJ cord-295545-ruxz77i8 21 27 range range NN cord-295545-ruxz77i8 21 28 of of IN cord-295545-ruxz77i8 21 29 cytokines cytokine NNS cord-295545-ruxz77i8 21 30 through through IN cord-295545-ruxz77i8 21 31 STATs stat NNS cord-295545-ruxz77i8 21 32 1 1 CD cord-295545-ruxz77i8 21 33 , , , cord-295545-ruxz77i8 21 34 2 2 CD cord-295545-ruxz77i8 21 35 , , , cord-295545-ruxz77i8 21 36 3 3 CD cord-295545-ruxz77i8 21 37 and and CC cord-295545-ruxz77i8 21 38 5 5 CD cord-295545-ruxz77i8 21 39 . . . cord-295545-ruxz77i8 22 1 This this DT cord-295545-ruxz77i8 22 2 has have VBZ cord-295545-ruxz77i8 22 3 profound profound JJ cord-295545-ruxz77i8 22 4 implications implication NNS cord-295545-ruxz77i8 22 5 for for IN cord-295545-ruxz77i8 22 6 strategies strategy NNS cord-295545-ruxz77i8 22 7 to to TO cord-295545-ruxz77i8 22 8 mitigate mitigate VB cord-295545-ruxz77i8 22 9 ACE2 ACE2 NNP cord-295545-ruxz77i8 22 10 levels level NNS cord-295545-ruxz77i8 22 11 . . . cord-295545-ruxz77i8 23 1 Interfering interfere VBG cord-295545-ruxz77i8 23 2 with with IN cord-295545-ruxz77i8 23 3 individual individual JJ cord-295545-ruxz77i8 23 4 STATs stat NNS cord-295545-ruxz77i8 23 5 will will MD cord-295545-ruxz77i8 23 6 result result VB cord-295545-ruxz77i8 23 7 in in IN cord-295545-ruxz77i8 23 8 the the DT cord-295545-ruxz77i8 23 9 compensational compensational JJ cord-295545-ruxz77i8 23 10 recruitment recruitment NN cord-295545-ruxz77i8 23 11 of of IN cord-295545-ruxz77i8 23 12 other other JJ cord-295545-ruxz77i8 23 13 STAT stat NN cord-295545-ruxz77i8 23 14 members member NNS cord-295545-ruxz77i8 23 15 to to IN cord-295545-ruxz77i8 23 16 cytokine cytokine JJ cord-295545-ruxz77i8 23 17 receptors receptor NNS cord-295545-ruxz77i8 23 18 ( ( -LRB- cord-295545-ruxz77i8 23 19 Cui Cui NNP cord-295545-ruxz77i8 23 20 et et FW cord-295545-ruxz77i8 23 21 al al NNP cord-295545-ruxz77i8 23 22 . . NNP cord-295545-ruxz77i8 23 23 , , , cord-295545-ruxz77i8 23 24 2007 2007 CD cord-295545-ruxz77i8 23 25 ) ) -RRB- cord-295545-ruxz77i8 23 26 with with IN cord-295545-ruxz77i8 23 27 all all PDT cord-295545-ruxz77i8 23 28 its -PRON- PRP$ cord-295545-ruxz77i8 23 29 transcriptional transcriptional JJ cord-295545-ruxz77i8 23 30 consequences consequence NNS cord-295545-ruxz77i8 23 31 ( ( -LRB- cord-295545-ruxz77i8 23 32 Hennighausen Hennighausen NNP cord-295545-ruxz77i8 23 33 and and CC cord-295545-ruxz77i8 23 34 Robinson Robinson NNP cord-295545-ruxz77i8 23 35 , , , cord-295545-ruxz77i8 23 36 2008 2008 CD cord-295545-ruxz77i8 23 37 ; ; : cord-295545-ruxz77i8 23 38 Shin Shin NNP cord-295545-ruxz77i8 23 39 et et NNP cord-295545-ruxz77i8 23 40 al al NNP cord-295545-ruxz77i8 23 41 . . NNP cord-295545-ruxz77i8 23 42 , , , cord-295545-ruxz77i8 23 43 2016 2016 CD cord-295545-ruxz77i8 23 44 ) ) -RRB- cord-295545-ruxz77i8 23 45 . . . cord-295545-ruxz77i8 24 1 Ace2 Ace2 NNP cord-295545-ruxz77i8 24 2 mRNA mRNA NNP cord-295545-ruxz77i8 24 3 levels level NNS cord-295545-ruxz77i8 24 4 vary vary VBP cord-295545-ruxz77i8 24 5 widely widely RB cord-295545-ruxz77i8 24 6 between between IN cord-295545-ruxz77i8 24 7 cell cell NN cord-295545-ruxz77i8 24 8 types type NNS cord-295545-ruxz77i8 24 9 , , , cord-295545-ruxz77i8 24 10 with with IN cord-295545-ruxz77i8 24 11 high high JJ cord-295545-ruxz77i8 24 12 expression expression NN cord-295545-ruxz77i8 24 13 detected detect VBN cord-295545-ruxz77i8 24 14 in in IN cord-295545-ruxz77i8 24 15 lactating lactate VBG cord-295545-ruxz77i8 24 16 mammary mammary JJ cord-295545-ruxz77i8 24 17 and and CC cord-295545-ruxz77i8 24 18 intestinal intestinal JJ cord-295545-ruxz77i8 24 19 tissues tissue NNS cord-295545-ruxz77i8 24 20 ( ( -LRB- cord-295545-ruxz77i8 24 21 Figure figure NN cord-295545-ruxz77i8 24 22 1A 1a NN cord-295545-ruxz77i8 24 23 -B -B NFP cord-295545-ruxz77i8 24 24 ) ) -RRB- cord-295545-ruxz77i8 24 25 and and CC cord-295545-ruxz77i8 24 26 Type Type NNP cord-295545-ruxz77i8 24 27 II II NNP cord-295545-ruxz77i8 24 28 Pneumocytes Pneumocytes NNPS cord-295545-ruxz77i8 24 29 ( ( -LRB- cord-295545-ruxz77i8 24 30 Ziegler Ziegler NNP cord-295545-ruxz77i8 24 31 , , , cord-295545-ruxz77i8 24 32 2020 2020 CD cord-295545-ruxz77i8 24 33 ) ) -RRB- cord-295545-ruxz77i8 24 34 . . . cord-295545-ruxz77i8 25 1 To to TO cord-295545-ruxz77i8 25 2 explore explore VB cord-295545-ruxz77i8 25 3 the the DT cord-295545-ruxz77i8 25 4 possibility possibility NN cord-295545-ruxz77i8 25 5 that that IN cord-295545-ruxz77i8 25 6 Ace2 Ace2 NNP cord-295545-ruxz77i8 25 7 gene gene NN cord-295545-ruxz77i8 25 8 expression expression NN cord-295545-ruxz77i8 25 9 in in IN cord-295545-ruxz77i8 25 10 SARS SARS NNP cord-295545-ruxz77i8 25 11 - - HYPH cord-295545-ruxz77i8 25 12 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 25 13 target target NN cord-295545-ruxz77i8 25 14 cells cell NNS cord-295545-ruxz77i8 25 15 is be VBZ cord-295545-ruxz77i8 25 16 regulated regulate VBN cord-295545-ruxz77i8 25 17 not not RB cord-295545-ruxz77i8 25 18 only only RB cord-295545-ruxz77i8 25 19 by by IN cord-295545-ruxz77i8 25 20 interferons interferon NNS cord-295545-ruxz77i8 25 21 but but CC cord-295545-ruxz77i8 25 22 also also RB cord-295545-ruxz77i8 25 23 by by IN cord-295545-ruxz77i8 25 24 a a DT cord-295545-ruxz77i8 25 25 range range NN cord-295545-ruxz77i8 25 26 of of IN cord-295545-ruxz77i8 25 27 cytokines cytokine NNS cord-295545-ruxz77i8 25 28 through through IN cord-295545-ruxz77i8 25 29 the the DT cord-295545-ruxz77i8 25 30 family family NN cord-295545-ruxz77i8 25 31 of of IN cord-295545-ruxz77i8 25 32 STAT stat NN cord-295545-ruxz77i8 25 33 transcription transcription NN cord-295545-ruxz77i8 25 34 factors factor NNS cord-295545-ruxz77i8 25 35 , , , cord-295545-ruxz77i8 25 36 we -PRON- PRP cord-295545-ruxz77i8 25 37 mined mine VBD cord-295545-ruxz77i8 25 38 available available JJ cord-295545-ruxz77i8 25 39 scRNA scrna JJ cord-295545-ruxz77i8 25 40 - - HYPH cord-295545-ruxz77i8 25 41 seq seq NN cord-295545-ruxz77i8 25 42 data datum NNS cord-295545-ruxz77i8 25 43 ( ( -LRB- cord-295545-ruxz77i8 25 44 Ziegler Ziegler NNP cord-295545-ruxz77i8 25 45 , , , cord-295545-ruxz77i8 25 46 2020 2020 CD cord-295545-ruxz77i8 25 47 ) ) -RRB- cord-295545-ruxz77i8 26 1 ( ( -LRB- cord-295545-ruxz77i8 26 2 Table table NN cord-295545-ruxz77i8 26 3 1 1 CD cord-295545-ruxz77i8 26 4 ) ) -RRB- cord-295545-ruxz77i8 26 5 . . . cord-295545-ruxz77i8 27 1 Interferon interferon NN cord-295545-ruxz77i8 27 2 receptors receptor NNS cord-295545-ruxz77i8 27 3 ( ( -LRB- cord-295545-ruxz77i8 27 4 IFNAR IFNAR NNP cord-295545-ruxz77i8 27 5 ) ) -RRB- cord-295545-ruxz77i8 27 6 and and CC cord-295545-ruxz77i8 27 7 its -PRON- PRP$ cord-295545-ruxz77i8 27 8 downstream downstream JJ cord-295545-ruxz77i8 27 9 mediators mediator NNS cord-295545-ruxz77i8 27 10 JAK1 JAK1 NNP cord-295545-ruxz77i8 27 11 , , , cord-295545-ruxz77i8 27 12 JAK2 JAK2 NNP cord-295545-ruxz77i8 27 13 , , , cord-295545-ruxz77i8 27 14 TYK2 TYK2 NNP cord-295545-ruxz77i8 27 15 as as RB cord-295545-ruxz77i8 27 16 well well RB cord-295545-ruxz77i8 27 17 as as IN cord-295545-ruxz77i8 27 18 STATs stat NNS cord-295545-ruxz77i8 27 19 1 1 CD cord-295545-ruxz77i8 27 20 , , , cord-295545-ruxz77i8 27 21 3 3 CD cord-295545-ruxz77i8 27 22 and and CC cord-295545-ruxz77i8 27 23 5 5 CD cord-295545-ruxz77i8 27 24 are be VBP cord-295545-ruxz77i8 27 25 highly highly RB cord-295545-ruxz77i8 27 26 expressed express VBN cord-295545-ruxz77i8 27 27 , , , cord-295545-ruxz77i8 27 28 thus thus RB cord-295545-ruxz77i8 27 29 supporting support VBG cord-295545-ruxz77i8 27 30 the the DT cord-295545-ruxz77i8 27 31 mechanism mechanism NN cord-295545-ruxz77i8 27 32 of of IN cord-295545-ruxz77i8 27 33 ACE2 ACE2 NNP cord-295545-ruxz77i8 27 34 induction induction NN cord-295545-ruxz77i8 27 35 by by IN cord-295545-ruxz77i8 27 36 IFN IFN NNP cord-295545-ruxz77i8 27 37 - - HYPH cord-295545-ruxz77i8 27 38 a a NNP cord-295545-ruxz77i8 27 39 / / SYM cord-295545-ruxz77i8 27 40 b b NN cord-295545-ruxz77i8 27 41 and and CC cord-295545-ruxz77i8 27 42 IFN IFN NNP cord-295545-ruxz77i8 27 43 - - HYPH cord-295545-ruxz77i8 27 44 g g NNP cord-295545-ruxz77i8 27 45 . . . cord-295545-ruxz77i8 28 1 STAT1 STAT1 NNP cord-295545-ruxz77i8 28 2 levels level NNS cord-295545-ruxz77i8 28 3 increase increase VBP cord-295545-ruxz77i8 28 4 sharply sharply RB cord-295545-ruxz77i8 28 5 in in IN cord-295545-ruxz77i8 28 6 cells cell NNS cord-295545-ruxz77i8 28 7 treated treat VBN cord-295545-ruxz77i8 28 8 with with IN cord-295545-ruxz77i8 28 9 IFNs ifn NNS cord-295545-ruxz77i8 28 10 , , , cord-295545-ruxz77i8 28 11 supporting support VBG cord-295545-ruxz77i8 28 12 the the DT cord-295545-ruxz77i8 28 13 notion notion NN cord-295545-ruxz77i8 28 14 of of IN cord-295545-ruxz77i8 28 15 an an DT cord-295545-ruxz77i8 28 16 autoregulatory autoregulatory NN cord-295545-ruxz77i8 28 17 loop loop NN cord-295545-ruxz77i8 28 18 ( ( -LRB- cord-295545-ruxz77i8 28 19 Yuasa Yuasa NNP cord-295545-ruxz77i8 28 20 and and CC cord-295545-ruxz77i8 28 21 Hijikata Hijikata NNP cord-295545-ruxz77i8 28 22 , , , cord-295545-ruxz77i8 28 23 2016 2016 CD cord-295545-ruxz77i8 28 24 ) ) -RRB- cord-295545-ruxz77i8 28 25 . . . cord-295545-ruxz77i8 29 1 Moreover moreover RB cord-295545-ruxz77i8 29 2 , , , cord-295545-ruxz77i8 29 3 these these DT cord-295545-ruxz77i8 29 4 expression expression NN cord-295545-ruxz77i8 29 5 data datum NNS cord-295545-ruxz77i8 29 6 point point NN cord-295545-ruxz77i8 29 7 to to IN cord-295545-ruxz77i8 29 8 the the DT cord-295545-ruxz77i8 29 9 presence presence NN cord-295545-ruxz77i8 29 10 of of IN cord-295545-ruxz77i8 29 11 functional functional JJ cord-295545-ruxz77i8 29 12 STAT3 STAT3 NNP cord-295545-ruxz77i8 29 13 and and CC cord-295545-ruxz77i8 29 14 STAT5 stat5 NN cord-295545-ruxz77i8 29 15 signaling signal VBG cord-295545-ruxz77i8 29 16 cascades cascade NNS cord-295545-ruxz77i8 29 17 . . . cord-295545-ruxz77i8 30 1 Interleukin interleukin NN cord-295545-ruxz77i8 30 2 receptors receptor NNS cord-295545-ruxz77i8 30 3 , , , cord-295545-ruxz77i8 30 4 such such JJ cord-295545-ruxz77i8 30 5 as as IN cord-295545-ruxz77i8 30 6 IL-7R IL-7R NNP cord-295545-ruxz77i8 30 7 , , , cord-295545-ruxz77i8 30 8 that that WDT cord-295545-ruxz77i8 30 9 are be VBP cord-295545-ruxz77i8 30 10 dependent dependent JJ cord-295545-ruxz77i8 30 11 on on IN cord-295545-ruxz77i8 30 12 the the DT cord-295545-ruxz77i8 30 13 common common JJ cord-295545-ruxz77i8 30 14 gamma gamma NN cord-295545-ruxz77i8 30 15 chain chain NN cord-295545-ruxz77i8 30 16 ( ( -LRB- cord-295545-ruxz77i8 30 17 IL2RG IL2RG NNP cord-295545-ruxz77i8 30 18 ) ) -RRB- cord-295545-ruxz77i8 30 19 , , , cord-295545-ruxz77i8 30 20 JAK1 JAK1 NNP cord-295545-ruxz77i8 30 21 and and CC cord-295545-ruxz77i8 30 22 JAK3 JAK3 NNPS cord-295545-ruxz77i8 30 23 are be VBP cord-295545-ruxz77i8 30 24 also also RB cord-295545-ruxz77i8 30 25 highly highly RB cord-295545-ruxz77i8 30 26 expressed express VBN cord-295545-ruxz77i8 30 27 . . . cord-295545-ruxz77i8 31 1 The the DT cord-295545-ruxz77i8 31 2 presence presence NN cord-295545-ruxz77i8 31 3 of of IN cord-295545-ruxz77i8 31 4 a a DT cord-295545-ruxz77i8 31 5 wide wide JJ cord-295545-ruxz77i8 31 6 range range NN cord-295545-ruxz77i8 31 7 of of IN cord-295545-ruxz77i8 31 8 cytokine cytokine NN cord-295545-ruxz77i8 31 9 receptors receptor NNS cord-295545-ruxz77i8 31 10 , , , cord-295545-ruxz77i8 31 11 JAKs jak NNS cord-295545-ruxz77i8 31 12 and and CC cord-295545-ruxz77i8 31 13 STATs stat NNS cord-295545-ruxz77i8 31 14 , , , cord-295545-ruxz77i8 31 15 suggests suggest VBZ cord-295545-ruxz77i8 31 16 that that IN cord-295545-ruxz77i8 31 17 Ace2 Ace2 NNP cord-295545-ruxz77i8 31 18 might may MD cord-295545-ruxz77i8 31 19 be be VB cord-295545-ruxz77i8 31 20 activated activate VBN cord-295545-ruxz77i8 31 21 by by IN cord-295545-ruxz77i8 31 22 a a DT cord-295545-ruxz77i8 31 23 broad broad JJ cord-295545-ruxz77i8 31 24 selection selection NN cord-295545-ruxz77i8 31 25 of of IN cord-295545-ruxz77i8 31 26 extracellular extracellular JJ cord-295545-ruxz77i8 31 27 cues cue NNS cord-295545-ruxz77i8 31 28 and and CC cord-295545-ruxz77i8 31 29 most most JJS cord-295545-ruxz77i8 31 30 cytokines cytokine NNS cord-295545-ruxz77i8 31 31 , , , cord-295545-ruxz77i8 31 32 including include VBG cord-295545-ruxz77i8 31 33 growth growth NN cord-295545-ruxz77i8 31 34 hormone hormone NN cord-295545-ruxz77i8 31 35 and and CC cord-295545-ruxz77i8 31 36 prolactin prolactin NN cord-295545-ruxz77i8 31 37 . . . cord-295545-ruxz77i8 32 1 We -PRON- PRP cord-295545-ruxz77i8 32 2 have have VBP cord-295545-ruxz77i8 32 3 tested test VBN cord-295545-ruxz77i8 32 4 this this DT cord-295545-ruxz77i8 32 5 premise premise NN cord-295545-ruxz77i8 32 6 and and CC cord-295545-ruxz77i8 32 7 explored explore VBD cord-295545-ruxz77i8 32 8 whether whether IN cord-295545-ruxz77i8 32 9 Ace2 Ace2 NNP cord-295545-ruxz77i8 32 10 is be VBZ cord-295545-ruxz77i8 32 11 activated activate VBN cord-295545-ruxz77i8 32 12 in in IN cord-295545-ruxz77i8 32 13 mouse mouse NN cord-295545-ruxz77i8 32 14 mammary mammary JJ cord-295545-ruxz77i8 32 15 tissue tissue NN cord-295545-ruxz77i8 32 16 through through IN cord-295545-ruxz77i8 32 17 STAT stat NN cord-295545-ruxz77i8 32 18 transcription transcription NN cord-295545-ruxz77i8 32 19 factors factor NNS cord-295545-ruxz77i8 32 20 . . . cord-295545-ruxz77i8 33 1 Gene gene NN cord-295545-ruxz77i8 33 2 expression expression NN cord-295545-ruxz77i8 33 3 in in IN cord-295545-ruxz77i8 33 4 mammary mammary JJ cord-295545-ruxz77i8 33 5 epithelium epithelium NN cord-295545-ruxz77i8 33 6 during during IN cord-295545-ruxz77i8 33 7 pregnancy pregnancy NN cord-295545-ruxz77i8 33 8 and and CC cord-295545-ruxz77i8 33 9 lactation lactation NN cord-295545-ruxz77i8 33 10 is be VBZ cord-295545-ruxz77i8 33 11 activated activate VBN cord-295545-ruxz77i8 33 12 by by IN cord-295545-ruxz77i8 33 13 prolactin prolactin NN cord-295545-ruxz77i8 33 14 through through IN cord-295545-ruxz77i8 33 15 STAT5 stat5 NN cord-295545-ruxz77i8 34 1 ( ( -LRB- cord-295545-ruxz77i8 34 2 Liu Liu NNP cord-295545-ruxz77i8 34 3 et et NNP cord-295545-ruxz77i8 34 4 al al NNP cord-295545-ruxz77i8 34 5 . . NNP cord-295545-ruxz77i8 34 6 , , , cord-295545-ruxz77i8 34 7 1997 1997 CD cord-295545-ruxz77i8 34 8 ) ) -RRB- cord-295545-ruxz77i8 34 9 . . . cord-295545-ruxz77i8 35 1 We -PRON- PRP cord-295545-ruxz77i8 35 2 observed observe VBD cord-295545-ruxz77i8 35 3 an an DT cord-295545-ruxz77i8 35 4 approximately approximately RB cord-295545-ruxz77i8 35 5 100-fold 100-fold CD cord-295545-ruxz77i8 35 6 increase increase NN cord-295545-ruxz77i8 35 7 of of IN cord-295545-ruxz77i8 35 8 Ace2 Ace2 NNP cord-295545-ruxz77i8 35 9 mRNA mrna NN cord-295545-ruxz77i8 35 10 during during IN cord-295545-ruxz77i8 35 11 pregnancy pregnancy NN cord-295545-ruxz77i8 35 12 and and CC cord-295545-ruxz77i8 35 13 lactation lactation NN cord-295545-ruxz77i8 35 14 ( ( -LRB- cord-295545-ruxz77i8 35 15 Figure figure NN cord-295545-ruxz77i8 35 16 1B 1b NN cord-295545-ruxz77i8 35 17 ) ) -RRB- cord-295545-ruxz77i8 35 18 , , , cord-295545-ruxz77i8 35 19 which which WDT cord-295545-ruxz77i8 35 20 coincided coincide VBD cord-295545-ruxz77i8 35 21 with with IN cord-295545-ruxz77i8 35 22 the the DT cord-295545-ruxz77i8 35 23 establishment establishment NN cord-295545-ruxz77i8 35 24 of of IN cord-295545-ruxz77i8 35 25 a a DT cord-295545-ruxz77i8 35 26 putative putative JJ cord-295545-ruxz77i8 35 27 enhancer enhancer NN cord-295545-ruxz77i8 35 28 ( ( -LRB- cord-295545-ruxz77i8 35 29 Figure figure NN cord-295545-ruxz77i8 35 30 2A 2a CD cord-295545-ruxz77i8 35 31 ) ) -RRB- cord-295545-ruxz77i8 35 32 . . . cord-295545-ruxz77i8 36 1 Tmprss2 Tmprss2 NNP cord-295545-ruxz77i8 37 1 mRNA mRNA NNP cord-295545-ruxz77i8 37 2 levels level NNS cord-295545-ruxz77i8 37 3 were be VBD cord-295545-ruxz77i8 37 4 similar similar JJ cord-295545-ruxz77i8 37 5 throughout throughout IN cord-295545-ruxz77i8 37 6 pregnancy pregnancy NN cord-295545-ruxz77i8 37 7 and and CC cord-295545-ruxz77i8 37 8 lactation lactation NN cord-295545-ruxz77i8 37 9 ( ( -LRB- cord-295545-ruxz77i8 37 10 Figure figure NN cord-295545-ruxz77i8 37 11 1B 1b NN cord-295545-ruxz77i8 37 12 ) ) -RRB- cord-295545-ruxz77i8 37 13 , , , cord-295545-ruxz77i8 37 14 suggesting suggest VBG cord-295545-ruxz77i8 37 15 that that IN cord-295545-ruxz77i8 37 16 its -PRON- PRP$ cord-295545-ruxz77i8 37 17 expression expression NN cord-295545-ruxz77i8 37 18 is be VBZ cord-295545-ruxz77i8 37 19 not not RB cord-295545-ruxz77i8 37 20 under under IN cord-295545-ruxz77i8 37 21 overt overt JJ cord-295545-ruxz77i8 37 22 control control NN cord-295545-ruxz77i8 37 23 of of IN cord-295545-ruxz77i8 37 24 the the DT cord-295545-ruxz77i8 37 25 JAK JAK NNP cord-295545-ruxz77i8 37 26 / / SYM cord-295545-ruxz77i8 37 27 STAT stat NN cord-295545-ruxz77i8 37 28 pathway pathway NN cord-295545-ruxz77i8 37 29 . . . cord-295545-ruxz77i8 38 1 STAT5 STAT5 NNP cord-295545-ruxz77i8 38 2 was be VBD cord-295545-ruxz77i8 38 3 recruited recruit VBN cord-295545-ruxz77i8 38 4 to to IN cord-295545-ruxz77i8 38 5 two two CD cord-295545-ruxz77i8 38 6 distinct distinct JJ cord-295545-ruxz77i8 38 7 GAS gas NN cord-295545-ruxz77i8 38 8 ( ( -LRB- cord-295545-ruxz77i8 38 9 bona bona FW cord-295545-ruxz77i8 38 10 fide fide FW cord-295545-ruxz77i8 38 11 STAT stat NN cord-295545-ruxz77i8 38 12 binding bind VBG cord-295545-ruxz77i8 38 13 motifs motif NNS cord-295545-ruxz77i8 38 14 ) ) -RRB- cord-295545-ruxz77i8 38 15 in in IN cord-295545-ruxz77i8 38 16 the the DT cord-295545-ruxz77i8 38 17 candidate candidate NN cord-295545-ruxz77i8 38 18 enhancer enhancer NN cord-295545-ruxz77i8 38 19 and and CC cord-295545-ruxz77i8 38 20 cooccupancy cooccupancy NN cord-295545-ruxz77i8 38 21 of of IN cord-295545-ruxz77i8 38 22 the the DT cord-295545-ruxz77i8 38 23 glucocorticoid glucocorticoid NN cord-295545-ruxz77i8 38 24 receptor receptor NN cord-295545-ruxz77i8 38 25 ( ( -LRB- cord-295545-ruxz77i8 38 26 GR GR NNP cord-295545-ruxz77i8 38 27 ) ) -RRB- cord-295545-ruxz77i8 38 28 , , , cord-295545-ruxz77i8 38 29 nuclear nuclear JJ cord-295545-ruxz77i8 38 30 factor factor NN cord-295545-ruxz77i8 38 31 1 1 CD cord-295545-ruxz77i8 38 32 B B NNP cord-295545-ruxz77i8 38 33 ( ( -LRB- cord-295545-ruxz77i8 38 34 NFIB NFIB NNP cord-295545-ruxz77i8 38 35 ) ) -RRB- cord-295545-ruxz77i8 38 36 and and CC cord-295545-ruxz77i8 38 37 mediator mediator NN cord-295545-ruxz77i8 38 38 complex complex JJ cord-295545-ruxz77i8 38 39 subunit subunit NN cord-295545-ruxz77i8 38 40 1 1 CD cord-295545-ruxz77i8 38 41 ( ( -LRB- cord-295545-ruxz77i8 38 42 MED1 MED1 NNP cord-295545-ruxz77i8 38 43 ) ) -RRB- cord-295545-ruxz77i8 38 44 is be VBZ cord-295545-ruxz77i8 38 45 likely likely JJ cord-295545-ruxz77i8 38 46 not not RB cord-295545-ruxz77i8 38 47 through through IN cord-295545-ruxz77i8 38 48 their -PRON- PRP$ cord-295545-ruxz77i8 38 49 individual individual JJ cord-295545-ruxz77i8 38 50 recognition recognition NN cord-295545-ruxz77i8 38 51 motifs motif NNS cord-295545-ruxz77i8 38 52 but but CC cord-295545-ruxz77i8 38 53 through through IN cord-295545-ruxz77i8 38 54 contacting contact VBG cord-295545-ruxz77i8 38 55 STAT5 stat5 NN cord-295545-ruxz77i8 38 56 . . . cord-295545-ruxz77i8 39 1 The the DT cord-295545-ruxz77i8 39 2 presence presence NN cord-295545-ruxz77i8 39 3 of of IN cord-295545-ruxz77i8 39 4 H3K4me1 H3K4me1 NNP cord-295545-ruxz77i8 39 5 enhancer enhancer NN cord-295545-ruxz77i8 39 6 marks mark NNS cord-295545-ruxz77i8 39 7 , , , cord-295545-ruxz77i8 39 8 H3K27ac h3k27ac CD cord-295545-ruxz77i8 39 9 marks mark NNS cord-295545-ruxz77i8 39 10 and and CC cord-295545-ruxz77i8 39 11 RNA RNA NNP cord-295545-ruxz77i8 39 12 polymerase polymerase NN cord-295545-ruxz77i8 39 13 II II NNP cord-295545-ruxz77i8 39 14 ( ( -LRB- cord-295545-ruxz77i8 39 15 Pol Pol NNP cord-295545-ruxz77i8 39 16 II II NNP cord-295545-ruxz77i8 39 17 ) ) -RRB- cord-295545-ruxz77i8 39 18 occupancy occupancy NN cord-295545-ruxz77i8 39 19 further further RB cord-295545-ruxz77i8 39 20 supports support VBZ cord-295545-ruxz77i8 39 21 the the DT cord-295545-ruxz77i8 39 22 validity validity NN cord-295545-ruxz77i8 39 23 of of IN cord-295545-ruxz77i8 39 24 this this DT cord-295545-ruxz77i8 39 25 regulatory regulatory JJ cord-295545-ruxz77i8 39 26 region region NN cord-295545-ruxz77i8 39 27 . . . cord-295545-ruxz77i8 40 1 Of of IN cord-295545-ruxz77i8 40 2 note note VB cord-295545-ruxz77i8 40 3 , , , cord-295545-ruxz77i8 40 4 no no DT cord-295545-ruxz77i8 40 5 STAT3 STAT3 NNP cord-295545-ruxz77i8 40 6 occupancy occupancy NN cord-295545-ruxz77i8 40 7 was be VBD cord-295545-ruxz77i8 40 8 observed observe VBN cord-295545-ruxz77i8 40 9 , , , cord-295545-ruxz77i8 40 10 suggesting suggest VBG cord-295545-ruxz77i8 40 11 a a DT cord-295545-ruxz77i8 40 12 predominance predominance NN cord-295545-ruxz77i8 40 13 of of IN cord-295545-ruxz77i8 40 14 STAT5 stat5 NN cord-295545-ruxz77i8 40 15 . . . cord-295545-ruxz77i8 41 1 In in IN cord-295545-ruxz77i8 41 2 contrast contrast NN cord-295545-ruxz77i8 41 3 to to IN cord-295545-ruxz77i8 41 4 mammary mammary JJ cord-295545-ruxz77i8 41 5 tissue tissue NN cord-295545-ruxz77i8 41 6 , , , cord-295545-ruxz77i8 41 7 limited limited JJ cord-295545-ruxz77i8 41 8 STAT5 stat5 NN cord-295545-ruxz77i8 41 9 binding binding NN cord-295545-ruxz77i8 41 10 was be VBD cord-295545-ruxz77i8 41 11 observed observe VBN cord-295545-ruxz77i8 41 12 in in IN cord-295545-ruxz77i8 41 13 liver liver NN cord-295545-ruxz77i8 41 14 and and CC cord-295545-ruxz77i8 41 15 no no UH cord-295545-ruxz77i8 41 16 STAT5 stat5 NN cord-295545-ruxz77i8 41 17 and and CC cord-295545-ruxz77i8 41 18 STAT3 STAT3 NNP cord-295545-ruxz77i8 42 1 binding bind VBG cord-295545-ruxz77i8 42 2 was be VBD cord-295545-ruxz77i8 42 3 observed observe VBN cord-295545-ruxz77i8 42 4 in in IN cord-295545-ruxz77i8 42 5 kidney kidney NN cord-295545-ruxz77i8 42 6 tissue tissue NN cord-295545-ruxz77i8 42 7 ( ( -LRB- cord-295545-ruxz77i8 42 8 Figure figure NN cord-295545-ruxz77i8 42 9 2B 2b CD cord-295545-ruxz77i8 42 10 ) ) -RRB- cord-295545-ruxz77i8 42 11 . . . cord-295545-ruxz77i8 43 1 The the DT cord-295545-ruxz77i8 43 2 putative putative JJ cord-295545-ruxz77i8 43 3 autoregulatory autoregulatory NN cord-295545-ruxz77i8 43 4 enhancer enhancer NN cord-295545-ruxz77i8 43 5 in in IN cord-295545-ruxz77i8 43 6 the the DT cord-295545-ruxz77i8 43 7 Stat1 Stat1 NNP cord-295545-ruxz77i8 43 8 gene gene NN cord-295545-ruxz77i8 43 9 served serve VBD cord-295545-ruxz77i8 43 10 as as IN cord-295545-ruxz77i8 43 11 a a DT cord-295545-ruxz77i8 43 12 positive positive JJ cord-295545-ruxz77i8 43 13 control control NN cord-295545-ruxz77i8 43 14 for for IN cord-295545-ruxz77i8 43 15 STAT stat NN cord-295545-ruxz77i8 43 16 binding binding NN cord-295545-ruxz77i8 43 17 ( ( -LRB- cord-295545-ruxz77i8 43 18 Figure figure NN cord-295545-ruxz77i8 43 19 2C 2c NN cord-295545-ruxz77i8 43 20 ) ) -RRB- cord-295545-ruxz77i8 43 21 . . . cord-295545-ruxz77i8 44 1 Our -PRON- PRP$ cord-295545-ruxz77i8 44 2 study study NN cord-295545-ruxz77i8 44 3 demonstrates demonstrate VBZ cord-295545-ruxz77i8 44 4 the the DT cord-295545-ruxz77i8 44 5 presence presence NN cord-295545-ruxz77i8 44 6 of of IN cord-295545-ruxz77i8 44 7 pan pan NNP cord-295545-ruxz77i8 44 8 JAK JAK NNP cord-295545-ruxz77i8 44 9 / / SYM cord-295545-ruxz77i8 44 10 STAT stat NN cord-295545-ruxz77i8 44 11 components component NNS cord-295545-ruxz77i8 44 12 in in IN cord-295545-ruxz77i8 44 13 Type Type NNP cord-295545-ruxz77i8 44 14 II II NNP cord-295545-ruxz77i8 44 15 Pneumocytes Pneumocytes NNPS cord-295545-ruxz77i8 44 16 , , , cord-295545-ruxz77i8 44 17 suggesting suggest VBG cord-295545-ruxz77i8 44 18 that that IN cord-295545-ruxz77i8 44 19 ACE2 ACE2 NNP cord-295545-ruxz77i8 44 20 is be VBZ cord-295545-ruxz77i8 44 21 not not RB cord-295545-ruxz77i8 44 22 only only RB cord-295545-ruxz77i8 44 23 activated activate VBN cord-295545-ruxz77i8 44 24 by by IN cord-295545-ruxz77i8 44 25 IFN IFN NNP cord-295545-ruxz77i8 44 26 - - HYPH cord-295545-ruxz77i8 44 27 a a NNP cord-295545-ruxz77i8 44 28 / / SYM cord-295545-ruxz77i8 44 29 b b NN cord-295545-ruxz77i8 44 30 and and CC cord-295545-ruxz77i8 44 31 IFN IFN NNP cord-295545-ruxz77i8 44 32 - - HYPH cord-295545-ruxz77i8 44 33 g g NNP cord-295545-ruxz77i8 45 1 but but CC cord-295545-ruxz77i8 45 2 also also RB cord-295545-ruxz77i8 45 3 by by IN cord-295545-ruxz77i8 45 4 other other JJ cord-295545-ruxz77i8 45 5 cytokines cytokine NNS cord-295545-ruxz77i8 45 6 . . . cord-295545-ruxz77i8 46 1 Moreover moreover RB cord-295545-ruxz77i8 46 2 , , , cord-295545-ruxz77i8 46 3 we -PRON- PRP cord-295545-ruxz77i8 46 4 demonstrate demonstrate VBP cord-295545-ruxz77i8 46 5 an an DT cord-295545-ruxz77i8 46 6 ~100-fold ~100-fold NNP cord-295545-ruxz77i8 46 7 increase increase NN cord-295545-ruxz77i8 46 8 of of IN cord-295545-ruxz77i8 46 9 Ace2 Ace2 NNP cord-295545-ruxz77i8 46 10 expression expression NN cord-295545-ruxz77i8 46 11 by by IN cord-295545-ruxz77i8 46 12 pregnancy pregnancy NN cord-295545-ruxz77i8 46 13 and and CC cord-295545-ruxz77i8 46 14 lactation lactation NN cord-295545-ruxz77i8 46 15 hormones hormone NNS cord-295545-ruxz77i8 46 16 in in IN cord-295545-ruxz77i8 46 17 mouse mouse NN cord-295545-ruxz77i8 46 18 mammary mammary JJ cord-295545-ruxz77i8 46 19 tissue tissue NN cord-295545-ruxz77i8 46 20 . . . cord-295545-ruxz77i8 47 1 Future future JJ cord-295545-ruxz77i8 47 2 inquiries inquiry NNS cord-295545-ruxz77i8 47 3 aimed aim VBN cord-295545-ruxz77i8 47 4 at at IN cord-295545-ruxz77i8 47 5 understanding understand VBG cord-295545-ruxz77i8 47 6 the the DT cord-295545-ruxz77i8 47 7 mechanism mechanism NN cord-295545-ruxz77i8 47 8 of of IN cord-295545-ruxz77i8 47 9 ACE2 ACE2 NNP cord-295545-ruxz77i8 47 10 gene gene NN cord-295545-ruxz77i8 47 11 regulation regulation NN cord-295545-ruxz77i8 47 12 in in IN cord-295545-ruxz77i8 47 13 potential potential JJ cord-295545-ruxz77i8 47 14 SARS SARS NNP cord-295545-ruxz77i8 47 15 - - HYPH cord-295545-ruxz77i8 47 16 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 47 17 target target NN cord-295545-ruxz77i8 47 18 cells cell NNS cord-295545-ruxz77i8 47 19 need need VBP cord-295545-ruxz77i8 47 20 to to TO cord-295545-ruxz77i8 47 21 address address VB cord-295545-ruxz77i8 47 22 the the DT cord-295545-ruxz77i8 47 23 pan pan JJ cord-295545-ruxz77i8 47 24 JAK JAK NNP cord-295545-ruxz77i8 47 25 - - HYPH cord-295545-ruxz77i8 47 26 STAT STAT NNP cord-295545-ruxz77i8 47 27 pathway pathway NN cord-295545-ruxz77i8 47 28 as as RB cord-295545-ruxz77i8 47 29 well well RB cord-295545-ruxz77i8 47 30 as as IN cord-295545-ruxz77i8 47 31 steroid steroid NN cord-295545-ruxz77i8 47 32 hormones hormone NNS cord-295545-ruxz77i8 47 33 , , , cord-295545-ruxz77i8 47 34 which which WDT cord-295545-ruxz77i8 47 35 might may MD cord-295545-ruxz77i8 47 36 explain explain VB cord-295545-ruxz77i8 47 37 some some DT cord-295545-ruxz77i8 47 38 of of IN cord-295545-ruxz77i8 47 39 the the DT cord-295545-ruxz77i8 47 40 sex sex NN cord-295545-ruxz77i8 47 41 differences difference NNS cord-295545-ruxz77i8 47 42 seen see VBN cord-295545-ruxz77i8 47 43 in in IN cord-295545-ruxz77i8 47 44 Covid-19 covid-19 NN cord-295545-ruxz77i8 47 45 morbidity morbidity NN cord-295545-ruxz77i8 47 46 and and CC cord-295545-ruxz77i8 47 47 mortality mortality NN cord-295545-ruxz77i8 47 48 . . . cord-295545-ruxz77i8 48 1 Such such JJ cord-295545-ruxz77i8 48 2 investigations investigation NNS cord-295545-ruxz77i8 48 3 would would MD cord-295545-ruxz77i8 48 4 need need VB cord-295545-ruxz77i8 48 5 to to TO cord-295545-ruxz77i8 48 6 include include VB cord-295545-ruxz77i8 48 7 experimental experimental JJ cord-295545-ruxz77i8 48 8 approaches approach NNS cord-295545-ruxz77i8 48 9 that that WDT cord-295545-ruxz77i8 48 10 comprehensively comprehensively RB cord-295545-ruxz77i8 48 11 interrogate interrogate VBP cord-295545-ruxz77i8 48 12 regulatory regulatory JJ cord-295545-ruxz77i8 48 13 elements element NNS cord-295545-ruxz77i8 48 14 controlling control VBG cord-295545-ruxz77i8 48 15 ACE2 ACE2 NNP cord-295545-ruxz77i8 48 16 expression expression NN cord-295545-ruxz77i8 48 17 in in IN cord-295545-ruxz77i8 48 18 vivo vivo NN cord-295545-ruxz77i8 48 19 in in IN cord-295545-ruxz77i8 48 20 human human JJ cord-295545-ruxz77i8 48 21 tissues tissue NNS cord-295545-ruxz77i8 48 22 , , , cord-295545-ruxz77i8 48 23 both both CC cord-295545-ruxz77i8 48 24 in in IN cord-295545-ruxz77i8 48 25 males male NNS cord-295545-ruxz77i8 48 26 and and CC cord-295545-ruxz77i8 48 27 females female NNS cord-295545-ruxz77i8 48 28 at at IN cord-295545-ruxz77i8 48 29 different different JJ cord-295545-ruxz77i8 48 30 ages age NNS cord-295545-ruxz77i8 48 31 . . . cord-295545-ruxz77i8 49 1 Since since IN cord-295545-ruxz77i8 49 2 underlying underlie VBG cord-295545-ruxz77i8 49 3 preexisting preexisting JJ cord-295545-ruxz77i8 49 4 conditions condition NNS cord-295545-ruxz77i8 49 5 , , , cord-295545-ruxz77i8 49 6 such such JJ cord-295545-ruxz77i8 49 7 as as IN cord-295545-ruxz77i8 49 8 obesity obesity NN cord-295545-ruxz77i8 49 9 , , , cord-295545-ruxz77i8 49 10 diabetes diabetes NN cord-295545-ruxz77i8 49 11 and and CC cord-295545-ruxz77i8 49 12 high high JJ cord-295545-ruxz77i8 49 13 blood blood NN cord-295545-ruxz77i8 49 14 pressure pressure NN cord-295545-ruxz77i8 49 15 , , , cord-295545-ruxz77i8 49 16 can can MD cord-295545-ruxz77i8 49 17 affect affect VB cord-295545-ruxz77i8 49 18 the the DT cord-295545-ruxz77i8 49 19 severity severity NN cord-295545-ruxz77i8 49 20 and and CC cord-295545-ruxz77i8 49 21 progression progression NN cord-295545-ruxz77i8 49 22 of of IN cord-295545-ruxz77i8 49 23 Covid-19 covid-19 NN cord-295545-ruxz77i8 49 24 , , , cord-295545-ruxz77i8 49 25 it -PRON- PRP cord-295545-ruxz77i8 49 26 would would MD cord-295545-ruxz77i8 49 27 prudent prudent VB cord-295545-ruxz77i8 49 28 to to TO cord-295545-ruxz77i8 49 29 take take VB cord-295545-ruxz77i8 49 30 this this DT cord-295545-ruxz77i8 49 31 into into IN cord-295545-ruxz77i8 49 32 account account NN cord-295545-ruxz77i8 49 33 when when WRB cord-295545-ruxz77i8 49 34 analyzing analyze VBG cord-295545-ruxz77i8 49 35 the the DT cord-295545-ruxz77i8 49 36 control control NN cord-295545-ruxz77i8 49 37 of of IN cord-295545-ruxz77i8 49 38 Ace2 Ace2 NNP cord-295545-ruxz77i8 49 39 regulation regulation NN cord-295545-ruxz77i8 49 40 . . . cord-295545-ruxz77i8 50 1 Chromatin Chromatin NNP cord-295545-ruxz77i8 50 2 immunoprecipitation immunoprecipitation NN cord-295545-ruxz77i8 50 3 sequencing sequencing NN cord-295545-ruxz77i8 50 4 ( ( -LRB- cord-295545-ruxz77i8 50 5 ChIP chip NN cord-295545-ruxz77i8 50 6 - - HYPH cord-295545-ruxz77i8 50 7 seq seq NN cord-295545-ruxz77i8 50 8 ) ) -RRB- cord-295545-ruxz77i8 50 9 analysis analysis NN cord-295545-ruxz77i8 50 10 . . . cord-295545-ruxz77i8 51 1 Quality quality NN cord-295545-ruxz77i8 51 2 filtering filtering NN cord-295545-ruxz77i8 51 3 and and CC cord-295545-ruxz77i8 51 4 alignment alignment NN cord-295545-ruxz77i8 51 5 of of IN cord-295545-ruxz77i8 51 6 the the DT cord-295545-ruxz77i8 51 7 raw raw JJ cord-295545-ruxz77i8 51 8 reads read NNS cord-295545-ruxz77i8 51 9 was be VBD cord-295545-ruxz77i8 51 10 done do VBN cord-295545-ruxz77i8 51 11 using use VBG cord-295545-ruxz77i8 51 12 Trimmomatic Trimmomatic NNP cord-295545-ruxz77i8 51 13 ( ( -LRB- cord-295545-ruxz77i8 51 14 Bolger Bolger NNP cord-295545-ruxz77i8 51 15 et et NNP cord-295545-ruxz77i8 51 16 al al NNP cord-295545-ruxz77i8 51 17 . . NNP cord-295545-ruxz77i8 51 18 , , , cord-295545-ruxz77i8 51 19 2014 2014 CD cord-295545-ruxz77i8 51 20 ) ) -RRB- cord-295545-ruxz77i8 51 21 was be VBD cord-295545-ruxz77i8 51 22 used use VBN cord-295545-ruxz77i8 51 23 for for IN cord-295545-ruxz77i8 51 24 visualization visualization NN cord-295545-ruxz77i8 51 25 . . . cord-295545-ruxz77i8 52 1 Coverage coverage NN cord-295545-ruxz77i8 52 2 plots plot NNS cord-295545-ruxz77i8 52 3 were be VBD cord-295545-ruxz77i8 52 4 generated generate VBN cord-295545-ruxz77i8 52 5 using use VBG cord-295545-ruxz77i8 52 6 Homer Homer NNP cord-295545-ruxz77i8 52 7 ( ( -LRB- cord-295545-ruxz77i8 52 8 Heinz Heinz NNP cord-295545-ruxz77i8 52 9 et et NNP cord-295545-ruxz77i8 52 10 al al NNP cord-295545-ruxz77i8 52 11 . . NNP cord-295545-ruxz77i8 52 12 , , , cord-295545-ruxz77i8 52 13 2010 2010 CD cord-295545-ruxz77i8 52 14 ) ) -RRB- cord-295545-ruxz77i8 52 15 software software NN cord-295545-ruxz77i8 52 16 with with IN cord-295545-ruxz77i8 52 17 the the DT cord-295545-ruxz77i8 52 18 bedGraph bedgraph NN cord-295545-ruxz77i8 52 19 from from IN cord-295545-ruxz77i8 52 20 deepTools deeptool NNS cord-295545-ruxz77i8 52 21 as as IN cord-295545-ruxz77i8 52 22 input input NN cord-295545-ruxz77i8 52 23 . . . cord-295545-ruxz77i8 53 1 R r NN cord-295545-ruxz77i8 53 2 and and CC cord-295545-ruxz77i8 53 3 the the DT cord-295545-ruxz77i8 53 4 packages package NNS cord-295545-ruxz77i8 53 5 dplyr dplyr NNS cord-295545-ruxz77i8 53 6 ( ( -LRB- cord-295545-ruxz77i8 53 7 https://CRAN.R-project.org/package=dplyr https://CRAN.R-project.org/package=dplyr NNP cord-295545-ruxz77i8 53 8 ) ) -RRB- cord-295545-ruxz77i8 53 9 and and CC cord-295545-ruxz77i8 53 10 ggplot2 ggplot2 NN cord-295545-ruxz77i8 53 11 ( ( -LRB- cord-295545-ruxz77i8 53 12 Love Love NNP cord-295545-ruxz77i8 53 13 et et NNP cord-295545-ruxz77i8 53 14 al al NNP cord-295545-ruxz77i8 53 15 . . NNP cord-295545-ruxz77i8 53 16 , , , cord-295545-ruxz77i8 53 17 2014 2014 CD cord-295545-ruxz77i8 53 18 ) ) -RRB- cord-295545-ruxz77i8 53 19 were be VBD cord-295545-ruxz77i8 53 20 used use VBN cord-295545-ruxz77i8 53 21 for for IN cord-295545-ruxz77i8 53 22 visualization visualization NN cord-295545-ruxz77i8 53 23 . . . cord-295545-ruxz77i8 54 1 Each each DT cord-295545-ruxz77i8 54 2 ChIP chip NN cord-295545-ruxz77i8 54 3 - - HYPH cord-295545-ruxz77i8 54 4 seq seq NN cord-295545-ruxz77i8 54 5 experiment experiment NN cord-295545-ruxz77i8 54 6 was be VBD cord-295545-ruxz77i8 54 7 conducted conduct VBN cord-295545-ruxz77i8 54 8 for for IN cord-295545-ruxz77i8 54 9 two two CD cord-295545-ruxz77i8 54 10 replicates replicate NNS cord-295545-ruxz77i8 54 11 . . . cord-295545-ruxz77i8 55 1 Sequence sequence NN cord-295545-ruxz77i8 55 2 read read VBD cord-295545-ruxz77i8 55 3 numbers number NNS cord-295545-ruxz77i8 55 4 were be VBD cord-295545-ruxz77i8 55 5 calculated calculate VBN cord-295545-ruxz77i8 55 6 using use VBG cord-295545-ruxz77i8 55 7 Samtools Samtools NNP cord-295545-ruxz77i8 55 8 ( ( -LRB- cord-295545-ruxz77i8 55 9 Masella Masella NNP cord-295545-ruxz77i8 55 10 et et NNP cord-295545-ruxz77i8 55 11 al al NNP cord-295545-ruxz77i8 55 12 . . NNP cord-295545-ruxz77i8 55 13 , , , cord-295545-ruxz77i8 55 14 2016 2016 CD cord-295545-ruxz77i8 55 15 ) ) -RRB- cord-295545-ruxz77i8 55 16 software software NN cord-295545-ruxz77i8 55 17 with with IN cord-295545-ruxz77i8 55 18 sorted sort VBN cord-295545-ruxz77i8 55 19 bam bam NNP cord-295545-ruxz77i8 55 20 files file NNS cord-295545-ruxz77i8 55 21 . . . cord-295545-ruxz77i8 56 1 The the DT cord-295545-ruxz77i8 56 2 correlation correlation NN cord-295545-ruxz77i8 56 3 between between IN cord-295545-ruxz77i8 56 4 the the DT cord-295545-ruxz77i8 56 5 ChIP chip NN cord-295545-ruxz77i8 56 6 - - HYPH cord-295545-ruxz77i8 56 7 seq seq NN cord-295545-ruxz77i8 56 8 replicates replicate NNS cord-295545-ruxz77i8 56 9 was be VBD cord-295545-ruxz77i8 56 10 computed compute VBN cord-295545-ruxz77i8 56 11 using use VBG cord-295545-ruxz77i8 56 12 deepTools deeptool NNS cord-295545-ruxz77i8 56 13 using use VBG cord-295545-ruxz77i8 56 14 Spearman Spearman NNP cord-295545-ruxz77i8 56 15 correlation correlation NN cord-295545-ruxz77i8 56 16 . . . cord-295545-ruxz77i8 57 1 RNA RNA NNP cord-295545-ruxz77i8 57 2 - - HYPH cord-295545-ruxz77i8 57 3 seq seq NN cord-295545-ruxz77i8 57 4 analysis analysis NN cord-295545-ruxz77i8 57 5 . . . cord-295545-ruxz77i8 58 1 RNA RNA NNP cord-295545-ruxz77i8 58 2 - - HYPH cord-295545-ruxz77i8 58 3 seq seq NNP cord-295545-ruxz77i8 58 4 reads read NNS cord-295545-ruxz77i8 58 5 were be VBD cord-295545-ruxz77i8 58 6 analyzed analyze VBN cord-295545-ruxz77i8 58 7 using use VBG cord-295545-ruxz77i8 58 8 Trimmomatic Trimmomatic NNP cord-295545-ruxz77i8 58 9 ( ( -LRB- cord-295545-ruxz77i8 58 10 Bolger Bolger NNP cord-295545-ruxz77i8 58 11 et et NNP cord-295545-ruxz77i8 58 12 al al NNP cord-295545-ruxz77i8 58 13 . . NNP cord-295545-ruxz77i8 58 14 , , , cord-295545-ruxz77i8 58 15 2014 2014 CD cord-295545-ruxz77i8 58 16 ) ) -RRB- cord-295545-ruxz77i8 58 17 ( ( -LRB- cord-295545-ruxz77i8 58 18 version version NN cord-295545-ruxz77i8 58 19 0.36 0.36 CD cord-295545-ruxz77i8 58 20 ) ) -RRB- cord-295545-ruxz77i8 58 21 to to TO cord-295545-ruxz77i8 58 22 check check VB cord-295545-ruxz77i8 58 23 read read VB cord-295545-ruxz77i8 58 24 quality quality NN cord-295545-ruxz77i8 58 25 ( ( -LRB- cord-295545-ruxz77i8 58 26 with with IN cord-295545-ruxz77i8 58 27 following following JJ cord-295545-ruxz77i8 58 28 parameters parameter NNS cord-295545-ruxz77i8 58 29 : : : cord-295545-ruxz77i8 58 30 LEADING leading NN cord-295545-ruxz77i8 58 31 : : : cord-295545-ruxz77i8 58 32 3 3 CD cord-295545-ruxz77i8 58 33 , , , cord-295545-ruxz77i8 58 34 TRAILING trailing NN cord-295545-ruxz77i8 58 35 : : : cord-295545-ruxz77i8 58 36 3 3 CD cord-295545-ruxz77i8 58 37 , , , cord-295545-ruxz77i8 58 38 SLIDINGWINDOW SLIDINGWINDOW NNP cord-295545-ruxz77i8 58 39 : : : cord-295545-ruxz77i8 59 1 4:20 4:20 CD cord-295545-ruxz77i8 59 2 , , , cord-295545-ruxz77i8 59 3 MINLEN MINLEN NNP cord-295545-ruxz77i8 59 4 : : : cord-295545-ruxz77i8 59 5 36 36 CD cord-295545-ruxz77i8 59 6 ) ) -RRB- cord-295545-ruxz77i8 59 7 . . . cord-295545-ruxz77i8 60 1 The the DT cord-295545-ruxz77i8 60 2 alignment alignment NN cord-295545-ruxz77i8 60 3 was be VBD cord-295545-ruxz77i8 60 4 performed perform VBN cord-295545-ruxz77i8 60 5 in in IN cord-295545-ruxz77i8 60 6 Bowtie Bowtie NNP cord-295545-ruxz77i8 60 7 aligner aligner NN cord-295545-ruxz77i8 61 1 ( ( -LRB- cord-295545-ruxz77i8 61 2 Langmead Langmead NNP cord-295545-ruxz77i8 61 3 et et NNP cord-295545-ruxz77i8 61 4 al al NNP cord-295545-ruxz77i8 61 5 . . NNP cord-295545-ruxz77i8 61 6 , , , cord-295545-ruxz77i8 61 7 2009 2009 CD cord-295545-ruxz77i8 61 8 ) ) -RRB- cord-295545-ruxz77i8 62 1 ( ( -LRB- cord-295545-ruxz77i8 62 2 version version NN cord-295545-ruxz77i8 62 3 1.1.2 1.1.2 CD cord-295545-ruxz77i8 62 4 ) ) -RRB- cord-295545-ruxz77i8 62 5 using use VBG cord-295545-ruxz77i8 62 6 paired pair VBN cord-295545-ruxz77i8 62 7 end end NN cord-295545-ruxz77i8 62 8 mode mode NN cord-295545-ruxz77i8 62 9 . . . cord-295545-ruxz77i8 63 1 RNA RNA NNP cord-295545-ruxz77i8 63 2 - - HYPH cord-295545-ruxz77i8 63 3 seq seq NN cord-295545-ruxz77i8 63 4 data datum NNS cord-295545-ruxz77i8 63 5 from from IN cord-295545-ruxz77i8 63 6 human human JJ cord-295545-ruxz77i8 63 7 and and CC cord-295545-ruxz77i8 63 8 mouse mouse NN cord-295545-ruxz77i8 63 9 tissues tissue NNS cord-295545-ruxz77i8 63 10 shown show VBN cord-295545-ruxz77i8 63 11 in in IN cord-295545-ruxz77i8 63 12 Figure figure NN cord-295545-ruxz77i8 63 13 1a 1a CD cord-295545-ruxz77i8 63 14 were be VBD cord-295545-ruxz77i8 63 15 obtained obtain VBN cord-295545-ruxz77i8 63 16 from from IN cord-295545-ruxz77i8 63 17 ENCODE encode NN cord-295545-ruxz77i8 63 18 . . . cord-295545-ruxz77i8 64 1 RNA RNA NNP cord-295545-ruxz77i8 64 2 - - HYPH cord-295545-ruxz77i8 64 3 seq seq NN cord-295545-ruxz77i8 64 4 data datum NNS cord-295545-ruxz77i8 64 5 shown show VBN cord-295545-ruxz77i8 64 6 in in IN cord-295545-ruxz77i8 64 7 Fig Fig NNP cord-295545-ruxz77i8 64 8 . . . cord-295545-ruxz77i8 65 1 1b 1b NNP cord-295545-ruxz77i8 65 2 _SP cord-295545-ruxz77i8 66 1 The the DT cord-295545-ruxz77i8 66 2 authors author NNS cord-295545-ruxz77i8 66 3 declare declare VBP cord-295545-ruxz77i8 66 4 not not RB cord-295545-ruxz77i8 66 5 competing compete VBG cord-295545-ruxz77i8 66 6 interests interest NNS cord-295545-ruxz77i8 66 7 . . . cord-295545-ruxz77i8 67 1 Table table NN cord-295545-ruxz77i8 67 2 1 1 CD cord-295545-ruxz77i8 67 3 . . . cord-295545-ruxz77i8 68 1 mRNA mRNA NNP cord-295545-ruxz77i8 68 2 levels level NNS cord-295545-ruxz77i8 68 3 of of IN cord-295545-ruxz77i8 68 4 genes gene NNS cord-295545-ruxz77i8 68 5 associated associate VBN cord-295545-ruxz77i8 68 6 with with IN cord-295545-ruxz77i8 68 7 the the DT cord-295545-ruxz77i8 68 8 pan pan JJ cord-295545-ruxz77i8 68 9 JAK JAK NNP cord-295545-ruxz77i8 68 10 - - HYPH cord-295545-ruxz77i8 68 11 STAT STAT NNP cord-295545-ruxz77i8 68 12 pathway pathway NN cord-295545-ruxz77i8 68 13 in in IN cord-295545-ruxz77i8 68 14 primary primary JJ cord-295545-ruxz77i8 68 15 human human JJ cord-295545-ruxz77i8 68 16 basal basal NN cord-295545-ruxz77i8 68 17 epithelial epithelial JJ cord-295545-ruxz77i8 68 18 cells cell NNS cord-295545-ruxz77i8 68 19 . . . cord-295545-ruxz77i8 69 1 scRNA scRNA NNP cord-295545-ruxz77i8 69 2 - - HYPH cord-295545-ruxz77i8 69 3 seq seq NN cord-295545-ruxz77i8 69 4 data datum NNS cord-295545-ruxz77i8 69 5 were be VBD cord-295545-ruxz77i8 69 6 extracted extract VBN cord-295545-ruxz77i8 69 7 from from IN cord-295545-ruxz77i8 69 8 the the DT cord-295545-ruxz77i8 69 9 study study NN cord-295545-ruxz77i8 69 10 by by IN cord-295545-ruxz77i8 69 11 Ziegler Ziegler NNP cord-295545-ruxz77i8 69 12 and and CC cord-295545-ruxz77i8 69 13 colleagues colleague NNS cord-295545-ruxz77i8 69 14 ( ( -LRB- cord-295545-ruxz77i8 69 15 Ziegler Ziegler NNP cord-295545-ruxz77i8 69 16 , , , cord-295545-ruxz77i8 69 17 2020 2020 CD cord-295545-ruxz77i8 69 18 ) ) -RRB- cord-295545-ruxz77i8 69 19 . . . cord-295545-ruxz77i8 70 1 The the DT cord-295545-ruxz77i8 70 2 human human JJ cord-295545-ruxz77i8 70 3 bronchial bronchial JJ cord-295545-ruxz77i8 70 4 cell cell NN cord-295545-ruxz77i8 70 5 line line NN cord-295545-ruxz77i8 70 6 ( ( -LRB- cord-295545-ruxz77i8 70 7 BEAS-2B BEAS-2B NNP cord-295545-ruxz77i8 70 8 ) ) -RRB- cord-295545-ruxz77i8 70 9 and and CC cord-295545-ruxz77i8 70 10 airway airway NN cord-295545-ruxz77i8 70 11 basal basal NN cord-295545-ruxz77i8 70 12 cells cell NNS cord-295545-ruxz77i8 70 13 from from IN cord-295545-ruxz77i8 70 14 human human JJ cord-295545-ruxz77i8 70 15 donors donor NNS cord-295545-ruxz77i8 70 16 had have VBD cord-295545-ruxz77i8 70 17 been be VBN cord-295545-ruxz77i8 70 18 exposed expose VBN cord-295545-ruxz77i8 70 19 to to IN cord-295545-ruxz77i8 70 20 interferons interferon NNS cord-295545-ruxz77i8 70 21 ( ( -LRB- cord-295545-ruxz77i8 70 22 IFNa2 IFNa2 NNP cord-295545-ruxz77i8 70 23 and and CC cord-295545-ruxz77i8 70 24 IFNg IFNg NNP cord-295545-ruxz77i8 70 25 ) ) -RRB- cord-295545-ruxz77i8 70 26 and and CC cord-295545-ruxz77i8 70 27 cytokines cytokine NNS cord-295545-ruxz77i8 70 28 ( ( -LRB- cord-295545-ruxz77i8 70 29 IL4 il4 NN cord-295545-ruxz77i8 70 30 and and CC cord-295545-ruxz77i8 70 31 IL17A il17a NN cord-295545-ruxz77i8 70 32 ) ) -RRB- cord-295545-ruxz77i8 70 33 . . . cord-295545-ruxz77i8 71 1 scRNA scRNA NNP cord-295545-ruxz77i8 71 2 - - HYPH cord-295545-ruxz77i8 71 3 seq seq NN cord-295545-ruxz77i8 71 4 libraries library NNS cord-295545-ruxz77i8 71 5 were be VBD cord-295545-ruxz77i8 71 6 generated generate VBN cord-295545-ruxz77i8 71 7 with with IN cord-295545-ruxz77i8 71 8 15,000 15,000 CD cord-295545-ruxz77i8 71 9 cells cell NNS cord-295545-ruxz77i8 71 10 . . . cord-295545-ruxz77i8 72 1 mRNA mrna NN cord-295545-ruxz77i8 72 2 levels level NNS cord-295545-ruxz77i8 72 3 for for IN cord-295545-ruxz77i8 72 4 genes gene NNS cord-295545-ruxz77i8 72 5 in in IN cord-295545-ruxz77i8 72 6 JAK JAK NNP cord-295545-ruxz77i8 72 7 / / SYM cord-295545-ruxz77i8 72 8 STAT stat NN cord-295545-ruxz77i8 72 9 signaling signal VBG cord-295545-ruxz77i8 72 10 pathway pathway NN cord-295545-ruxz77i8 72 11 were be VBD cord-295545-ruxz77i8 72 12 collected collect VBN cord-295545-ruxz77i8 72 13 from from IN cord-295545-ruxz77i8 72 14 the the DT cord-295545-ruxz77i8 72 15 data datum NNS cord-295545-ruxz77i8 72 16 and and CC cord-295545-ruxz77i8 72 17 averages average NNS cord-295545-ruxz77i8 72 18 of of IN cord-295545-ruxz77i8 72 19 independent independent JJ cord-295545-ruxz77i8 72 20 biological biological JJ cord-295545-ruxz77i8 72 21 replicates replicate NNS cord-295545-ruxz77i8 72 22 were be VBD cord-295545-ruxz77i8 72 23 normalized normalize VBN cord-295545-ruxz77i8 72 24 to to IN cord-295545-ruxz77i8 72 25 the the DT cord-295545-ruxz77i8 72 26 value value NN cord-295545-ruxz77i8 72 27 of of IN cord-295545-ruxz77i8 72 28 untreated untreated JJ cord-295545-ruxz77i8 72 29 group group NN cord-295545-ruxz77i8 72 30 . . . cord-295545-ruxz77i8 73 1 Genes gene NNS cord-295545-ruxz77i8 73 2 that that WDT cord-295545-ruxz77i8 73 3 were be VBD cord-295545-ruxz77i8 73 4 regulated regulate VBN cord-295545-ruxz77i8 73 5 more more JJR cord-295545-ruxz77i8 73 6 than than IN cord-295545-ruxz77i8 73 7 3-fold 3-fold CD cord-295545-ruxz77i8 73 8 by by IN cord-295545-ruxz77i8 73 9 interferons interferon NNS cord-295545-ruxz77i8 73 10 and and CC cord-295545-ruxz77i8 73 11 cytokines cytokine NNS cord-295545-ruxz77i8 73 12 are be VBP cord-295545-ruxz77i8 73 13 marked mark VBN cord-295545-ruxz77i8 73 14 in in IN cord-295545-ruxz77i8 73 15 red red JJ cord-295545-ruxz77i8 73 16 and and CC cord-295545-ruxz77i8 73 17 highlighted highlight VBN cord-295545-ruxz77i8 73 18 colors color NNS cord-295545-ruxz77i8 73 19 . . . cord-295545-ruxz77i8 74 1 Trimmomatic Trimmomatic NNP cord-295545-ruxz77i8 74 2 : : : cord-295545-ruxz77i8 75 1 a a DT cord-295545-ruxz77i8 75 2 flexible flexible JJ cord-295545-ruxz77i8 75 3 trimmer trimmer NN cord-295545-ruxz77i8 75 4 for for IN cord-295545-ruxz77i8 75 5 Illumina Illumina NNP cord-295545-ruxz77i8 75 6 sequence sequence NN cord-295545-ruxz77i8 75 7 data data NN cord-295545-ruxz77i8 75 8 Non non JJ cord-295545-ruxz77i8 75 9 - - JJ cord-295545-ruxz77i8 75 10 neuronal neuronal JJ cord-295545-ruxz77i8 75 11 expression expression NN cord-295545-ruxz77i8 75 12 of of IN cord-295545-ruxz77i8 75 13 SARS SARS NNP cord-295545-ruxz77i8 75 14 - - HYPH cord-295545-ruxz77i8 75 15 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 75 16 entry entry NN cord-295545-ruxz77i8 75 17 genes gene NNS cord-295545-ruxz77i8 75 18 in in IN cord-295545-ruxz77i8 75 19 the the DT cord-295545-ruxz77i8 75 20 olfactory olfactory JJ cord-295545-ruxz77i8 75 21 system system NN cord-295545-ruxz77i8 75 22 suggests suggest VBZ cord-295545-ruxz77i8 75 23 mechanisms mechanism NNS cord-295545-ruxz77i8 75 24 underlying underlie VBG cord-295545-ruxz77i8 75 25 COVID-19-associated covid-19-associated JJ cord-295545-ruxz77i8 75 26 anosmia anosmia NN cord-295545-ruxz77i8 75 27 Loss Loss NNP cord-295545-ruxz77i8 75 28 of of IN cord-295545-ruxz77i8 75 29 signal signal NN cord-295545-ruxz77i8 75 30 transducer transducer NN cord-295545-ruxz77i8 75 31 and and CC cord-295545-ruxz77i8 75 32 activator activator NN cord-295545-ruxz77i8 75 33 of of IN cord-295545-ruxz77i8 75 34 transcription transcription NN cord-295545-ruxz77i8 75 35 5 5 CD cord-295545-ruxz77i8 75 36 leads lead NNS cord-295545-ruxz77i8 75 37 to to IN cord-295545-ruxz77i8 75 38 hepatosteatosis hepatosteatosis NN cord-295545-ruxz77i8 75 39 and and CC cord-295545-ruxz77i8 75 40 impaired impaired JJ cord-295545-ruxz77i8 75 41 liver liver NN cord-295545-ruxz77i8 75 42 regeneration regeneration NN cord-295545-ruxz77i8 75 43 Simple simple JJ cord-295545-ruxz77i8 75 44 combinations combination NNS cord-295545-ruxz77i8 75 45 of of IN cord-295545-ruxz77i8 75 46 lineage lineage NN cord-295545-ruxz77i8 75 47 - - HYPH cord-295545-ruxz77i8 75 48 determining determine VBG cord-295545-ruxz77i8 75 49 transcription transcription NN cord-295545-ruxz77i8 75 50 factors factor NNS cord-295545-ruxz77i8 75 51 prime prime NNP cord-295545-ruxz77i8 75 52 cis cis JJ cord-295545-ruxz77i8 75 53 - - HYPH cord-295545-ruxz77i8 75 54 regulatory regulatory JJ cord-295545-ruxz77i8 75 55 elements element NNS cord-295545-ruxz77i8 75 56 required require VBN cord-295545-ruxz77i8 75 57 for for IN cord-295545-ruxz77i8 75 58 macrophage macrophage NN cord-295545-ruxz77i8 75 59 and and CC cord-295545-ruxz77i8 75 60 B b NN cord-295545-ruxz77i8 75 61 cell cell NN cord-295545-ruxz77i8 75 62 identities identity NNS cord-295545-ruxz77i8 75 63 Interpretation Interpretation NNP cord-295545-ruxz77i8 75 64 of of IN cord-295545-ruxz77i8 75 65 cytokine cytokine NN cord-295545-ruxz77i8 75 66 signaling signal VBG cord-295545-ruxz77i8 75 67 through through IN cord-295545-ruxz77i8 75 68 the the DT cord-295545-ruxz77i8 75 69 transcription transcription NN cord-295545-ruxz77i8 75 70 factors factor NNS cord-295545-ruxz77i8 75 71 STAT5A STAT5A NNP cord-295545-ruxz77i8 75 72 and and CC cord-295545-ruxz77i8 75 73 STAT5B STAT5B NNP cord-295545-ruxz77i8 76 1 SARS SARS NNP cord-295545-ruxz77i8 76 2 - - HYPH cord-295545-ruxz77i8 76 3 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 76 4 Cell Cell NNP cord-295545-ruxz77i8 76 5 Entry entry NN cord-295545-ruxz77i8 76 6 Depends depend VBZ cord-295545-ruxz77i8 76 7 on on IN cord-295545-ruxz77i8 76 8 ACE2 ACE2 NNP cord-295545-ruxz77i8 76 9 and and CC cord-295545-ruxz77i8 76 10 TMPRSS2 TMPRSS2 NNP cord-295545-ruxz77i8 76 11 and and CC cord-295545-ruxz77i8 76 12 Is be VBZ cord-295545-ruxz77i8 76 13 Blocked block VBN cord-295545-ruxz77i8 76 14 by by IN cord-295545-ruxz77i8 77 1 a a DT cord-295545-ruxz77i8 77 2 Clinically Clinically NNP cord-295545-ruxz77i8 77 3 Proven prove VBN cord-295545-ruxz77i8 77 4 Protease protease NN cord-295545-ruxz77i8 77 5 Inhibitor Inhibitor NNP cord-295545-ruxz77i8 77 6 Angiotensin Angiotensin NNP cord-295545-ruxz77i8 77 7 - - HYPH cord-295545-ruxz77i8 77 8 converting convert VBG cord-295545-ruxz77i8 77 9 enzyme enzyme NN cord-295545-ruxz77i8 77 10 2 2 CD cord-295545-ruxz77i8 77 11 protects protect VBZ cord-295545-ruxz77i8 77 12 from from IN cord-295545-ruxz77i8 77 13 severe severe JJ cord-295545-ruxz77i8 77 14 acute acute JJ cord-295545-ruxz77i8 77 15 lung lung NN cord-295545-ruxz77i8 77 16 failure failure NN cord-295545-ruxz77i8 78 1 SARS SARS NNP cord-295545-ruxz77i8 78 2 - - HYPH cord-295545-ruxz77i8 78 3 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 78 4 productively productively RB cord-295545-ruxz77i8 78 5 infects infect VBZ cord-295545-ruxz77i8 78 6 human human JJ cord-295545-ruxz77i8 78 7 gut gut NN cord-295545-ruxz77i8 78 8 enterocytes enterocytes NNPS cord-295545-ruxz77i8 78 9 Ultrafast Ultrafast NNP cord-295545-ruxz77i8 78 10 and and CC cord-295545-ruxz77i8 78 11 memoryefficient memoryefficient JJ cord-295545-ruxz77i8 78 12 alignment alignment NN cord-295545-ruxz77i8 78 13 of of IN cord-295545-ruxz77i8 78 14 short short JJ cord-295545-ruxz77i8 78 15 DNA dna NN cord-295545-ruxz77i8 78 16 sequences sequence NNS cord-295545-ruxz77i8 78 17 to to IN cord-295545-ruxz77i8 78 18 the the DT cord-295545-ruxz77i8 78 19 human human JJ cord-295545-ruxz77i8 78 20 genome genome NN cord-295545-ruxz77i8 78 21 Stat5a Stat5a NNP cord-295545-ruxz77i8 78 22 is be VBZ cord-295545-ruxz77i8 78 23 mandatory mandatory JJ cord-295545-ruxz77i8 78 24 for for IN cord-295545-ruxz77i8 78 25 adult adult NN cord-295545-ruxz77i8 78 26 mammary mammary JJ cord-295545-ruxz77i8 78 27 gland gland NN cord-295545-ruxz77i8 78 28 development development NN cord-295545-ruxz77i8 78 29 and and CC cord-295545-ruxz77i8 78 30 lactogenesis lactogenesis NN cord-295545-ruxz77i8 78 31 Moderated moderate VBD cord-295545-ruxz77i8 78 32 estimation estimation NN cord-295545-ruxz77i8 78 33 of of IN cord-295545-ruxz77i8 78 34 fold fold JJ cord-295545-ruxz77i8 78 35 change change NN cord-295545-ruxz77i8 78 36 and and CC cord-295545-ruxz77i8 78 37 dispersion dispersion NN cord-295545-ruxz77i8 78 38 for for IN cord-295545-ruxz77i8 78 39 RNA RNA NNP cord-295545-ruxz77i8 78 40 - - HYPH cord-295545-ruxz77i8 78 41 seq seq NN cord-295545-ruxz77i8 78 42 data datum NNS cord-295545-ruxz77i8 78 43 with with IN cord-295545-ruxz77i8 78 44 DESeq2 DESeq2 NNP cord-295545-ruxz77i8 78 45 SARS SARS NNP cord-295545-ruxz77i8 78 46 - - HYPH cord-295545-ruxz77i8 78 47 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 78 48 receptor receptor NN cord-295545-ruxz77i8 78 49 ACE2 ACE2 NNP cord-295545-ruxz77i8 78 50 and and CC cord-295545-ruxz77i8 78 51 TMPRSS2 TMPRSS2 NNP cord-295545-ruxz77i8 78 52 are be VBP cord-295545-ruxz77i8 78 53 primarily primarily RB cord-295545-ruxz77i8 78 54 expressed express VBN cord-295545-ruxz77i8 78 55 in in IN cord-295545-ruxz77i8 78 56 bronchial bronchial JJ cord-295545-ruxz77i8 78 57 transient transient JJ cord-295545-ruxz77i8 78 58 secretory secretory NN cord-295545-ruxz77i8 78 59 cells cell NNS cord-295545-ruxz77i8 78 60 BAMQL BAMQL NNP cord-295545-ruxz77i8 78 61 : : : cord-295545-ruxz77i8 79 1 a a DT cord-295545-ruxz77i8 79 2 query query NN cord-295545-ruxz77i8 79 3 language language NN cord-295545-ruxz77i8 79 4 for for IN cord-295545-ruxz77i8 79 5 extracting extract VBG cord-295545-ruxz77i8 79 6 reads read NNS cord-295545-ruxz77i8 79 7 from from IN cord-295545-ruxz77i8 79 8 BAM BAM NNP cord-295545-ruxz77i8 79 9 files file VBZ cord-295545-ruxz77i8 79 10 Single single JJ cord-295545-ruxz77i8 79 11 cell cell NN cord-295545-ruxz77i8 79 12 RNA rna NN cord-295545-ruxz77i8 79 13 sequencing sequencing NN cord-295545-ruxz77i8 79 14 of of IN cord-295545-ruxz77i8 79 15 13 13 CD cord-295545-ruxz77i8 79 16 human human JJ cord-295545-ruxz77i8 79 17 tissues tissue NNS cord-295545-ruxz77i8 80 1 identify identify VB cord-295545-ruxz77i8 80 2 cell cell NN cord-295545-ruxz77i8 80 3 types type NNS cord-295545-ruxz77i8 80 4 and and CC cord-295545-ruxz77i8 80 5 receptors receptor NNS cord-295545-ruxz77i8 80 6 of of IN cord-295545-ruxz77i8 80 7 human human JJ cord-295545-ruxz77i8 80 8 coronaviruses coronaviruse NNS cord-295545-ruxz77i8 80 9 deepTools2 deepTools2 NNS cord-295545-ruxz77i8 80 10 : : : cord-295545-ruxz77i8 80 11 a a DT cord-295545-ruxz77i8 80 12 next next JJ cord-295545-ruxz77i8 80 13 generation generation NN cord-295545-ruxz77i8 80 14 web web NN cord-295545-ruxz77i8 80 15 server server NN cord-295545-ruxz77i8 80 16 for for IN cord-295545-ruxz77i8 80 17 deepsequencing deepsequence VBG cord-295545-ruxz77i8 80 18 data datum NNS cord-295545-ruxz77i8 80 19 analysis analysis NN cord-295545-ruxz77i8 80 20 Hierarchy Hierarchy NNP cord-295545-ruxz77i8 80 21 within within IN cord-295545-ruxz77i8 80 22 the the DT cord-295545-ruxz77i8 80 23 mammary mammary JJ cord-295545-ruxz77i8 80 24 STAT5-driven STAT5-driven NNP cord-295545-ruxz77i8 80 25 Wap Wap NNP cord-295545-ruxz77i8 80 26 super super JJ cord-295545-ruxz77i8 80 27 - - NN cord-295545-ruxz77i8 80 28 enhancer enhancer NN cord-295545-ruxz77i8 81 1 The the DT cord-295545-ruxz77i8 81 2 JAK JAK NNP cord-295545-ruxz77i8 81 3 - - HYPH cord-295545-ruxz77i8 81 4 STAT stat NN cord-295545-ruxz77i8 81 5 pathway pathway NN cord-295545-ruxz77i8 81 6 at at IN cord-295545-ruxz77i8 81 7 twenty twenty CD cord-295545-ruxz77i8 81 8 Integrative Integrative NNP cord-295545-ruxz77i8 81 9 Genomics Genomics NNPS cord-295545-ruxz77i8 81 10 Viewer viewer NN cord-295545-ruxz77i8 81 11 ( ( -LRB- cord-295545-ruxz77i8 81 12 IGV igv NN cord-295545-ruxz77i8 81 13 ) ) -RRB- cord-295545-ruxz77i8 81 14 : : : cord-295545-ruxz77i8 81 15 high high JJ cord-295545-ruxz77i8 81 16 - - HYPH cord-295545-ruxz77i8 81 17 performance performance NN cord-295545-ruxz77i8 81 18 genomics genomic NNS cord-295545-ruxz77i8 81 19 data datum NNS cord-295545-ruxz77i8 81 20 visualization visualization NN cord-295545-ruxz77i8 81 21 and and CC cord-295545-ruxz77i8 81 22 exploration exploration NN cord-295545-ruxz77i8 81 23 Coronavirus Coronavirus NNP cord-295545-ruxz77i8 81 24 disease disease NN cord-295545-ruxz77i8 81 25 2019 2019 CD cord-295545-ruxz77i8 81 26 among among IN cord-295545-ruxz77i8 81 27 pregnant pregnant JJ cord-295545-ruxz77i8 81 28 Chinese chinese JJ cord-295545-ruxz77i8 81 29 women woman NNS cord-295545-ruxz77i8 81 30 : : : cord-295545-ruxz77i8 81 31 Case case NN cord-295545-ruxz77i8 81 32 series series NN cord-295545-ruxz77i8 81 33 data datum NNS cord-295545-ruxz77i8 81 34 on on IN cord-295545-ruxz77i8 81 35 the the DT cord-295545-ruxz77i8 81 36 safety safety NN cord-295545-ruxz77i8 81 37 of of IN cord-295545-ruxz77i8 81 38 vaginal vaginal JJ cord-295545-ruxz77i8 81 39 birth birth NN cord-295545-ruxz77i8 81 40 and and CC cord-295545-ruxz77i8 81 41 breastfeeding breastfeeding NN cord-295545-ruxz77i8 81 42 Distal distal JJ cord-295545-ruxz77i8 81 43 regulatory regulatory JJ cord-295545-ruxz77i8 81 44 element element NN cord-295545-ruxz77i8 81 45 of of IN cord-295545-ruxz77i8 81 46 the the DT cord-295545-ruxz77i8 81 47 STAT1 stat1 NN cord-295545-ruxz77i8 81 48 gene gene NN cord-295545-ruxz77i8 81 49 potentially potentially RB cord-295545-ruxz77i8 81 50 mediates mediate VBZ cord-295545-ruxz77i8 81 51 positive positive JJ cord-295545-ruxz77i8 81 52 feedback feedback NN cord-295545-ruxz77i8 81 53 control control NN cord-295545-ruxz77i8 81 54 of of IN cord-295545-ruxz77i8 81 55 STAT1 stat1 NN cord-295545-ruxz77i8 81 56 expression expression NN cord-295545-ruxz77i8 81 57 Single single JJ cord-295545-ruxz77i8 81 58 - - HYPH cord-295545-ruxz77i8 81 59 cell cell NN cord-295545-ruxz77i8 81 60 RNA rna NN cord-295545-ruxz77i8 81 61 expression expression NN cord-295545-ruxz77i8 81 62 profiling profiling NN cord-295545-ruxz77i8 81 63 of of IN cord-295545-ruxz77i8 81 64 ACE2 ACE2 NNP cord-295545-ruxz77i8 81 65 , , , cord-295545-ruxz77i8 81 66 the the DT cord-295545-ruxz77i8 81 67 receptor receptor NN cord-295545-ruxz77i8 81 68 of of IN cord-295545-ruxz77i8 81 69 SARS SARS NNP cord-295545-ruxz77i8 81 70 - - HYPH cord-295545-ruxz77i8 81 71 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 81 72 SARS SARS NNP cord-295545-ruxz77i8 81 73 - - HYPH cord-295545-ruxz77i8 81 74 CoV-2 CoV-2 NNP cord-295545-ruxz77i8 81 75 receptor receptor NN cord-295545-ruxz77i8 81 76 ACE2 ACE2 NNP cord-295545-ruxz77i8 82 1 is be VBZ cord-295545-ruxz77i8 82 2 an an DT cord-295545-ruxz77i8 82 3 interferon interferon NN cord-295545-ruxz77i8 82 4 - - HYPH cord-295545-ruxz77i8 82 5 stimulated stimulate VBN cord-295545-ruxz77i8 82 6 gene gene NN cord-295545-ruxz77i8 82 7 in in IN cord-295545-ruxz77i8 82 8 human human JJ cord-295545-ruxz77i8 82 9 airway airway NN cord-295545-ruxz77i8 82 10 epithelial epithelial JJ cord-295545-ruxz77i8 82 11 cells cell NNS cord-295545-ruxz77i8 82 12 and and CC cord-295545-ruxz77i8 82 13 is be VBZ cord-295545-ruxz77i8 82 14 detected detect VBN cord-295545-ruxz77i8 82 15 in in IN cord-295545-ruxz77i8 82 16 specific specific JJ cord-295545-ruxz77i8 82 17 cell cell NN cord-295545-ruxz77i8 82 18 subsets subset NNS cord-295545-ruxz77i8 82 19 across across IN cord-295545-ruxz77i8 82 20 tissues tissue NNS