id sid tid token lemma pos cord-284627-qvz63m93 1 1 key key NN cord-284627-qvz63m93 1 2 : : : cord-284627-qvz63m93 2 1 cord-284627-qvz63m93 cord-284627-qvz63m93 NNP cord-284627-qvz63m93 2 2 authors author NNS cord-284627-qvz63m93 2 3 : : : cord-284627-qvz63m93 2 4 Banerjee Banerjee NNP cord-284627-qvz63m93 2 5 , , , cord-284627-qvz63m93 2 6 Shuvam Shuvam NNP cord-284627-qvz63m93 2 7 ; ; : cord-284627-qvz63m93 2 8 Dhar Dhar NNP cord-284627-qvz63m93 2 9 , , , cord-284627-qvz63m93 2 10 Shrinjana Shrinjana NNP cord-284627-qvz63m93 2 11 ; ; : cord-284627-qvz63m93 2 12 Bhattacharjee Bhattacharjee NNP cord-284627-qvz63m93 2 13 , , , cord-284627-qvz63m93 2 14 Sandip Sandip NNP cord-284627-qvz63m93 2 15 ; ; : cord-284627-qvz63m93 2 16 Bhattacharjee Bhattacharjee NNP cord-284627-qvz63m93 2 17 , , , cord-284627-qvz63m93 2 18 Pritha Pritha NNP cord-284627-qvz63m93 2 19 title title NN cord-284627-qvz63m93 2 20 : : : cord-284627-qvz63m93 2 21 Decoding decode VBG cord-284627-qvz63m93 2 22 the the DT cord-284627-qvz63m93 2 23 lethal lethal JJ cord-284627-qvz63m93 2 24 effect effect NN cord-284627-qvz63m93 2 25 of of IN cord-284627-qvz63m93 2 26 SARS SARS NNP cord-284627-qvz63m93 2 27 - - HYPH cord-284627-qvz63m93 2 28 CoV-2 CoV-2 NNP cord-284627-qvz63m93 2 29 ( ( -LRB- cord-284627-qvz63m93 2 30 novel novel JJ cord-284627-qvz63m93 2 31 coronavirus coronavirus NN cord-284627-qvz63m93 2 32 ) ) -RRB- cord-284627-qvz63m93 2 33 strains strain NNS cord-284627-qvz63m93 2 34 from from IN cord-284627-qvz63m93 2 35 global global JJ cord-284627-qvz63m93 2 36 perspective perspective NN cord-284627-qvz63m93 2 37 : : : cord-284627-qvz63m93 2 38 molecular molecular JJ cord-284627-qvz63m93 2 39 pathogenesis pathogenesis NN cord-284627-qvz63m93 2 40 and and CC cord-284627-qvz63m93 2 41 evolutionary evolutionary JJ cord-284627-qvz63m93 2 42 divergence divergence NN cord-284627-qvz63m93 2 43 date date NN cord-284627-qvz63m93 2 44 : : : cord-284627-qvz63m93 2 45 2020 2020 CD cord-284627-qvz63m93 2 46 - - HYPH cord-284627-qvz63m93 2 47 04 04 CD cord-284627-qvz63m93 2 48 - - HYPH cord-284627-qvz63m93 2 49 09 09 CD cord-284627-qvz63m93 2 50 journal journal NN cord-284627-qvz63m93 2 51 : : : cord-284627-qvz63m93 3 1 bioRxiv biorxiv IN cord-284627-qvz63m93 3 2 DOI DOI NNP cord-284627-qvz63m93 3 3 : : : cord-284627-qvz63m93 4 1 10.1101/2020.04.06.027854 10.1101/2020.04.06.027854 CD cord-284627-qvz63m93 4 2 sha sha NN cord-284627-qvz63m93 4 3 : : : cord-284627-qvz63m93 4 4 54bef708e1c63787767ac584461cb124d254fda8 54bef708e1c63787767ac584461cb124d254fda8 CD cord-284627-qvz63m93 4 5 doc_id doc_id CD cord-284627-qvz63m93 4 6 : : : cord-284627-qvz63m93 4 7 284627 284627 CD cord-284627-qvz63m93 4 8 cord_uid cord_uid NNS cord-284627-qvz63m93 4 9 : : : cord-284627-qvz63m93 5 1 qvz63m93 qvz63m93 NNP cord-284627-qvz63m93 6 1 Background Background NNP cord-284627-qvz63m93 6 2 COVID-19 COVID-19 NNP cord-284627-qvz63m93 6 3 is be VBZ cord-284627-qvz63m93 6 4 a a DT cord-284627-qvz63m93 6 5 disease disease NN cord-284627-qvz63m93 6 6 with with IN cord-284627-qvz63m93 6 7 global global JJ cord-284627-qvz63m93 6 8 public public JJ cord-284627-qvz63m93 6 9 health health NN cord-284627-qvz63m93 6 10 emergency emergency NN cord-284627-qvz63m93 6 11 that that WDT cord-284627-qvz63m93 6 12 have have VBP cord-284627-qvz63m93 6 13 shook shake VBN cord-284627-qvz63m93 6 14 the the DT cord-284627-qvz63m93 6 15 world world NN cord-284627-qvz63m93 6 16 since since IN cord-284627-qvz63m93 6 17 its -PRON- PRP$ cord-284627-qvz63m93 6 18 ’ ' `` cord-284627-qvz63m93 6 19 first first JJ cord-284627-qvz63m93 6 20 detection detection NN cord-284627-qvz63m93 6 21 in in IN cord-284627-qvz63m93 6 22 China China NNP cord-284627-qvz63m93 6 23 in in IN cord-284627-qvz63m93 6 24 December December NNP cord-284627-qvz63m93 6 25 , , , cord-284627-qvz63m93 6 26 2019 2019 CD cord-284627-qvz63m93 6 27 . . . cord-284627-qvz63m93 7 1 Severe severe JJ cord-284627-qvz63m93 7 2 acute acute JJ cord-284627-qvz63m93 7 3 respiratory respiratory JJ cord-284627-qvz63m93 7 4 syndrome syndrome NN cord-284627-qvz63m93 7 5 Coronavirus Coronavirus NNP cord-284627-qvz63m93 7 6 2 2 CD cord-284627-qvz63m93 8 1 ( ( -LRB- cord-284627-qvz63m93 8 2 SARS SARS NNP cord-284627-qvz63m93 8 3 - - HYPH cord-284627-qvz63m93 8 4 CoV-2 CoV-2 NNP cord-284627-qvz63m93 8 5 ) ) -RRB- cord-284627-qvz63m93 8 6 is be VBZ cord-284627-qvz63m93 8 7 the the DT cord-284627-qvz63m93 8 8 pathogen pathogen NN cord-284627-qvz63m93 8 9 responsible responsible JJ cord-284627-qvz63m93 8 10 behind behind IN cord-284627-qvz63m93 8 11 this this DT cord-284627-qvz63m93 8 12 pandemic pandemic NN cord-284627-qvz63m93 8 13 . . . cord-284627-qvz63m93 9 1 The the DT cord-284627-qvz63m93 9 2 lethality lethality NN cord-284627-qvz63m93 9 3 of of IN cord-284627-qvz63m93 9 4 different different JJ cord-284627-qvz63m93 9 5 viral viral JJ cord-284627-qvz63m93 9 6 strains strain NNS cord-284627-qvz63m93 9 7 is be VBZ cord-284627-qvz63m93 9 8 found find VBN cord-284627-qvz63m93 9 9 to to TO cord-284627-qvz63m93 9 10 vary vary VB cord-284627-qvz63m93 9 11 in in IN cord-284627-qvz63m93 9 12 different different JJ cord-284627-qvz63m93 9 13 geographical geographical JJ cord-284627-qvz63m93 9 14 locations location NNS cord-284627-qvz63m93 9 15 but but CC cord-284627-qvz63m93 9 16 the the DT cord-284627-qvz63m93 9 17 molecular molecular JJ cord-284627-qvz63m93 9 18 mechanism mechanism NN cord-284627-qvz63m93 9 19 is be VBZ cord-284627-qvz63m93 9 20 yet yet RB cord-284627-qvz63m93 9 21 to to TO cord-284627-qvz63m93 9 22 be be VB cord-284627-qvz63m93 9 23 known know VBN cord-284627-qvz63m93 9 24 . . . cord-284627-qvz63m93 10 1 Methods method NNS cord-284627-qvz63m93 10 2 Available available JJ cord-284627-qvz63m93 10 3 data datum NNS cord-284627-qvz63m93 10 4 of of IN cord-284627-qvz63m93 10 5 whole whole JJ cord-284627-qvz63m93 10 6 genome genome NN cord-284627-qvz63m93 10 7 sequencing sequencing NN cord-284627-qvz63m93 10 8 of of IN cord-284627-qvz63m93 10 9 different different JJ cord-284627-qvz63m93 10 10 viral viral JJ cord-284627-qvz63m93 10 11 strains strain NNS cord-284627-qvz63m93 10 12 published publish VBN cord-284627-qvz63m93 10 13 by by IN cord-284627-qvz63m93 10 14 different different JJ cord-284627-qvz63m93 10 15 countries country NNS cord-284627-qvz63m93 10 16 were be VBD cord-284627-qvz63m93 10 17 retrieved retrieve VBN cord-284627-qvz63m93 10 18 and and CC cord-284627-qvz63m93 10 19 then then RB cord-284627-qvz63m93 10 20 analysed analyse VBD cord-284627-qvz63m93 10 21 using use VBG cord-284627-qvz63m93 10 22 Multiple Multiple NNP cord-284627-qvz63m93 10 23 Sequence Sequence NNP cord-284627-qvz63m93 10 24 Alignment Alignment NNP cord-284627-qvz63m93 10 25 and and CC cord-284627-qvz63m93 10 26 Pair pair NN cord-284627-qvz63m93 10 27 - - HYPH cord-284627-qvz63m93 10 28 wise wise JJ cord-284627-qvz63m93 10 29 Sequence sequence NN cord-284627-qvz63m93 10 30 Alignment Alignment NNP cord-284627-qvz63m93 10 31 leading lead VBG cord-284627-qvz63m93 10 32 to to IN cord-284627-qvz63m93 10 33 Phylogenetic phylogenetic JJ cord-284627-qvz63m93 10 34 tree tree NN cord-284627-qvz63m93 10 35 construction construction NN cord-284627-qvz63m93 10 36 . . . cord-284627-qvz63m93 11 1 Each each DT cord-284627-qvz63m93 11 2 location location NN cord-284627-qvz63m93 11 3 and and CC cord-284627-qvz63m93 11 4 the the DT cord-284627-qvz63m93 11 5 corresponding corresponding JJ cord-284627-qvz63m93 11 6 genetic genetic JJ cord-284627-qvz63m93 11 7 variations variation NNS cord-284627-qvz63m93 11 8 were be VBD cord-284627-qvz63m93 11 9 screened screen VBN cord-284627-qvz63m93 11 10 in in IN cord-284627-qvz63m93 11 11 depth depth NN cord-284627-qvz63m93 11 12 . . . cord-284627-qvz63m93 12 1 Then then RB cord-284627-qvz63m93 12 2 the the DT cord-284627-qvz63m93 12 3 variations variation NNS cord-284627-qvz63m93 12 4 are be VBP cord-284627-qvz63m93 12 5 analysed analyse VBN cord-284627-qvz63m93 12 6 at at IN cord-284627-qvz63m93 12 7 protein protein NN cord-284627-qvz63m93 12 8 level level NN cord-284627-qvz63m93 12 9 giving give VBG cord-284627-qvz63m93 12 10 special special JJ cord-284627-qvz63m93 12 11 emphasis emphasis NN cord-284627-qvz63m93 12 12 on on IN cord-284627-qvz63m93 12 13 Non Non NNP cord-284627-qvz63m93 12 14 Synonymous Synonymous NNP cord-284627-qvz63m93 12 15 amino amino NN cord-284627-qvz63m93 12 16 acid acid NN cord-284627-qvz63m93 12 17 substitutions substitution NNS cord-284627-qvz63m93 12 18 . . . cord-284627-qvz63m93 13 1 The the DT cord-284627-qvz63m93 13 2 fatality fatality NN cord-284627-qvz63m93 13 3 rates rate NNS cord-284627-qvz63m93 13 4 in in IN cord-284627-qvz63m93 13 5 different different JJ cord-284627-qvz63m93 13 6 countries country NNS cord-284627-qvz63m93 13 7 were be VBD cord-284627-qvz63m93 13 8 matched match VBN cord-284627-qvz63m93 13 9 against against IN cord-284627-qvz63m93 13 10 the the DT cord-284627-qvz63m93 13 11 mutation mutation NN cord-284627-qvz63m93 13 12 number number NN cord-284627-qvz63m93 13 13 , , , cord-284627-qvz63m93 13 14 rarity rarity NN cord-284627-qvz63m93 13 15 of of IN cord-284627-qvz63m93 13 16 the the DT cord-284627-qvz63m93 13 17 nucleotide nucleotide JJ cord-284627-qvz63m93 13 18 alterations alteration NNS cord-284627-qvz63m93 13 19 and and CC cord-284627-qvz63m93 13 20 functional functional JJ cord-284627-qvz63m93 13 21 impact impact NN cord-284627-qvz63m93 13 22 of of IN cord-284627-qvz63m93 13 23 the the DT cord-284627-qvz63m93 13 24 Non Non NNP cord-284627-qvz63m93 13 25 Synonymous Synonymous NNP cord-284627-qvz63m93 13 26 changes change NNS cord-284627-qvz63m93 13 27 at at IN cord-284627-qvz63m93 13 28 protein protein NN cord-284627-qvz63m93 13 29 level level NN cord-284627-qvz63m93 13 30 , , , cord-284627-qvz63m93 13 31 separately separately RB cord-284627-qvz63m93 13 32 and and CC cord-284627-qvz63m93 13 33 in in IN cord-284627-qvz63m93 13 34 combination combination NN cord-284627-qvz63m93 13 35 . . . cord-284627-qvz63m93 14 1 Findings finding NNS cord-284627-qvz63m93 15 1 All all PDT cord-284627-qvz63m93 15 2 the the DT cord-284627-qvz63m93 15 3 viral viral JJ cord-284627-qvz63m93 15 4 strains strain NNS cord-284627-qvz63m93 15 5 have have VBP cord-284627-qvz63m93 15 6 been be VBN cord-284627-qvz63m93 15 7 found find VBN cord-284627-qvz63m93 15 8 to to TO cord-284627-qvz63m93 15 9 evolve evolve VB cord-284627-qvz63m93 15 10 from from IN cord-284627-qvz63m93 15 11 the the DT cord-284627-qvz63m93 15 12 viral viral JJ cord-284627-qvz63m93 15 13 strain strain NN cord-284627-qvz63m93 15 14 of of IN cord-284627-qvz63m93 15 15 Taiwan Taiwan NNP cord-284627-qvz63m93 15 16 ( ( -LRB- cord-284627-qvz63m93 15 17 MT192759 mt192759 NN cord-284627-qvz63m93 15 18 ) ) -RRB- cord-284627-qvz63m93 15 19 which which WDT cord-284627-qvz63m93 15 20 is be VBZ cord-284627-qvz63m93 15 21 100 100 CD cord-284627-qvz63m93 15 22 % % NN cord-284627-qvz63m93 15 23 identical identical JJ cord-284627-qvz63m93 15 24 with with IN cord-284627-qvz63m93 15 25 the the DT cord-284627-qvz63m93 15 26 ancestor ancestor NN cord-284627-qvz63m93 15 27 SARS SARS NNP cord-284627-qvz63m93 15 28 - - HYPH cord-284627-qvz63m93 15 29 CoV-2 CoV-2 NNP cord-284627-qvz63m93 15 30 sequences sequence NNS cord-284627-qvz63m93 15 31 of of IN cord-284627-qvz63m93 15 32 Wuhan Wuhan NNP cord-284627-qvz63m93 15 33 ( ( -LRB- cord-284627-qvz63m93 15 34 NC NC NNP cord-284627-qvz63m93 15 35 045512.2 045512.2 CD cord-284627-qvz63m93 15 36 ; ; : cord-284627-qvz63m93 15 37 submitted submit VBN cord-284627-qvz63m93 15 38 on on IN cord-284627-qvz63m93 15 39 5th 5th JJ cord-284627-qvz63m93 15 40 Jan Jan NNP cord-284627-qvz63m93 15 41 , , , cord-284627-qvz63m93 15 42 2020 2020 CD cord-284627-qvz63m93 15 43 ) ) -RRB- cord-284627-qvz63m93 15 44 . . . cord-284627-qvz63m93 16 1 Transition transition NN cord-284627-qvz63m93 16 2 from from IN cord-284627-qvz63m93 16 3 C C NNP cord-284627-qvz63m93 16 4 to to IN cord-284627-qvz63m93 16 5 T t NN cord-284627-qvz63m93 16 6 ( ( -LRB- cord-284627-qvz63m93 16 7 C c NN cord-284627-qvz63m93 16 8 > > XX cord-284627-qvz63m93 16 9 T t NN cord-284627-qvz63m93 16 10 ) ) -RRB- cord-284627-qvz63m93 16 11 is be VBZ cord-284627-qvz63m93 16 12 the the DT cord-284627-qvz63m93 16 13 most most RBS cord-284627-qvz63m93 16 14 frequent frequent JJ cord-284627-qvz63m93 16 15 mutation mutation NN cord-284627-qvz63m93 16 16 in in IN cord-284627-qvz63m93 16 17 this this DT cord-284627-qvz63m93 16 18 viral viral JJ cord-284627-qvz63m93 16 19 genome genome NN cord-284627-qvz63m93 16 20 and and CC cord-284627-qvz63m93 16 21 mutations mutation NNS cord-284627-qvz63m93 17 1 A a DT cord-284627-qvz63m93 18 1 > > XX cord-284627-qvz63m93 18 2 T T NNP cord-284627-qvz63m93 18 3 , , , cord-284627-qvz63m93 18 4 G g NN cord-284627-qvz63m93 18 5 > > XX cord-284627-qvz63m93 19 1 A a LS cord-284627-qvz63m93 19 2 , , , cord-284627-qvz63m93 19 3 T t NN cord-284627-qvz63m93 19 4 > > XX cord-284627-qvz63m93 20 1 A a DT cord-284627-qvz63m93 20 2 are be VBP cord-284627-qvz63m93 20 3 the the DT cord-284627-qvz63m93 20 4 rarest rare JJS cord-284627-qvz63m93 20 5 ones one NNS cord-284627-qvz63m93 20 6 , , , cord-284627-qvz63m93 20 7 found find VBN cord-284627-qvz63m93 20 8 in in IN cord-284627-qvz63m93 20 9 countries country NNS cord-284627-qvz63m93 20 10 with with IN cord-284627-qvz63m93 20 11 maximum maximum JJ cord-284627-qvz63m93 20 12 fatality fatality NN cord-284627-qvz63m93 20 13 rate rate NN cord-284627-qvz63m93 20 14 i.e i.e XX cord-284627-qvz63m93 20 15 Italy Italy NNP cord-284627-qvz63m93 20 16 , , , cord-284627-qvz63m93 20 17 Spain Spain NNP cord-284627-qvz63m93 20 18 and and CC cord-284627-qvz63m93 20 19 Sweden Sweden NNP cord-284627-qvz63m93 20 20 . . . cord-284627-qvz63m93 21 1 20 20 CD cord-284627-qvz63m93 22 1 Non Non NNP cord-284627-qvz63m93 22 2 Synonymous Synonymous NNP cord-284627-qvz63m93 22 3 mutations mutation NNS cord-284627-qvz63m93 22 4 are be VBP cord-284627-qvz63m93 22 5 located locate VBN cord-284627-qvz63m93 22 6 in in IN cord-284627-qvz63m93 22 7 viral viral JJ cord-284627-qvz63m93 22 8 genome genome NN cord-284627-qvz63m93 22 9 spanning span VBG cord-284627-qvz63m93 22 10 Orf1ab Orf1ab NNP cord-284627-qvz63m93 22 11 polyprotein polyprotein NN cord-284627-qvz63m93 22 12 , , , cord-284627-qvz63m93 22 13 Surface Surface NNP cord-284627-qvz63m93 22 14 glycoprotein glycoprotein NN cord-284627-qvz63m93 22 15 , , , cord-284627-qvz63m93 22 16 Nucleocapsid Nucleocapsid NNP cord-284627-qvz63m93 22 17 protein protein NN cord-284627-qvz63m93 22 18 etc etc FW cord-284627-qvz63m93 22 19 . . . cord-284627-qvz63m93 23 1 The the DT cord-284627-qvz63m93 23 2 functional functional JJ cord-284627-qvz63m93 23 3 effect effect NN cord-284627-qvz63m93 23 4 on on IN cord-284627-qvz63m93 23 5 the the DT cord-284627-qvz63m93 23 6 structure structure NN cord-284627-qvz63m93 23 7 and and CC cord-284627-qvz63m93 23 8 function function NN cord-284627-qvz63m93 23 9 of of IN cord-284627-qvz63m93 23 10 the the DT cord-284627-qvz63m93 23 11 protein protein NN cord-284627-qvz63m93 23 12 can can MD cord-284627-qvz63m93 23 13 favourably favourably RB cord-284627-qvz63m93 23 14 or or CC cord-284627-qvz63m93 23 15 unfavourably unfavourably RB cord-284627-qvz63m93 23 16 interact interact VB cord-284627-qvz63m93 23 17 with with IN cord-284627-qvz63m93 23 18 the the DT cord-284627-qvz63m93 23 19 host host NN cord-284627-qvz63m93 23 20 body body NN cord-284627-qvz63m93 23 21 . . . cord-284627-qvz63m93 24 1 Interpretation interpretation NN cord-284627-qvz63m93 25 1 The the DT cord-284627-qvz63m93 25 2 fatality fatality NN cord-284627-qvz63m93 25 3 outcome outcome NN cord-284627-qvz63m93 25 4 depends depend VBZ cord-284627-qvz63m93 25 5 on on IN cord-284627-qvz63m93 25 6 three three CD cord-284627-qvz63m93 25 7 important important JJ cord-284627-qvz63m93 25 8 factors factor NNS cord-284627-qvz63m93 25 9 ( ( -LRB- cord-284627-qvz63m93 25 10 a a LS cord-284627-qvz63m93 25 11 ) ) -RRB- cord-284627-qvz63m93 25 12 number number NN cord-284627-qvz63m93 25 13 of of IN cord-284627-qvz63m93 25 14 mutation mutation NN cord-284627-qvz63m93 25 15 ( ( -LRB- cord-284627-qvz63m93 25 16 b b NN cord-284627-qvz63m93 25 17 ) ) -RRB- cord-284627-qvz63m93 25 18 rarity rarity NN cord-284627-qvz63m93 25 19 of of IN cord-284627-qvz63m93 25 20 the the DT cord-284627-qvz63m93 25 21 allelic allelic JJ cord-284627-qvz63m93 25 22 variation variation NN cord-284627-qvz63m93 25 23 and and CC cord-284627-qvz63m93 25 24 ( ( -LRB- cord-284627-qvz63m93 25 25 c c NN cord-284627-qvz63m93 25 26 ) ) -RRB- cord-284627-qvz63m93 25 27 functional functional JJ cord-284627-qvz63m93 25 28 consequence consequence NN cord-284627-qvz63m93 25 29 of of IN cord-284627-qvz63m93 25 30 the the DT cord-284627-qvz63m93 25 31 mutation mutation NN cord-284627-qvz63m93 25 32 at at IN cord-284627-qvz63m93 25 33 protein protein NN cord-284627-qvz63m93 25 34 level level NN cord-284627-qvz63m93 25 35 . . . cord-284627-qvz63m93 26 1 The the DT cord-284627-qvz63m93 26 2 molecular molecular JJ cord-284627-qvz63m93 26 3 divergence divergence NN cord-284627-qvz63m93 26 4 , , , cord-284627-qvz63m93 26 5 evolved evolve VBD cord-284627-qvz63m93 26 6 from from IN cord-284627-qvz63m93 26 7 the the DT cord-284627-qvz63m93 26 8 ancestral ancestral JJ cord-284627-qvz63m93 26 9 strain strain NN cord-284627-qvz63m93 26 10 ( ( -LRB- cord-284627-qvz63m93 26 11 S s NN cord-284627-qvz63m93 26 12 ) ) -RRB- cord-284627-qvz63m93 26 13 lead lead NN cord-284627-qvz63m93 26 14 to to IN cord-284627-qvz63m93 26 15 extremely extremely RB cord-284627-qvz63m93 26 16 lethal lethal JJ cord-284627-qvz63m93 26 17 ( ( -LRB- cord-284627-qvz63m93 26 18 E e NN cord-284627-qvz63m93 26 19 ) ) -RRB- cord-284627-qvz63m93 26 20 , , , cord-284627-qvz63m93 26 21 lethal(L lethal(L NNP cord-284627-qvz63m93 26 22 ) ) -RRB- cord-284627-qvz63m93 27 1 and and CC cord-284627-qvz63m93 27 2 non non AFX cord-284627-qvz63m93 27 3 lethal lethal JJ cord-284627-qvz63m93 27 4 ( ( -LRB- cord-284627-qvz63m93 27 5 N n NN cord-284627-qvz63m93 27 6 ) ) -RRB- cord-284627-qvz63m93 27 7 strains strain VBZ cord-284627-qvz63m93 27 8 with with IN cord-284627-qvz63m93 27 9 the the DT cord-284627-qvz63m93 27 10 involvement involvement NN cord-284627-qvz63m93 27 11 of of IN cord-284627-qvz63m93 27 12 an an DT cord-284627-qvz63m93 27 13 Intermediate Intermediate NNP cord-284627-qvz63m93 27 14 strain(I strain(i NN cord-284627-qvz63m93 27 15 ) ) -RRB- cord-284627-qvz63m93 27 16 . . . cord-284627-qvz63m93 28 1 In in IN cord-284627-qvz63m93 28 2 the the DT cord-284627-qvz63m93 28 3 new new JJ cord-284627-qvz63m93 28 4 decade decade NN cord-284627-qvz63m93 28 5 of of IN cord-284627-qvz63m93 28 6 21 21 CD cord-284627-qvz63m93 28 7 st st NNP cord-284627-qvz63m93 28 8 century century NN cord-284627-qvz63m93 28 9 , , , cord-284627-qvz63m93 28 10 surfaced surface VBD cord-284627-qvz63m93 28 11 the the DT cord-284627-qvz63m93 28 12 first first JJ cord-284627-qvz63m93 28 13 public public JJ cord-284627-qvz63m93 28 14 health health NN cord-284627-qvz63m93 28 15 emergency emergency NN cord-284627-qvz63m93 28 16 of of IN cord-284627-qvz63m93 28 17 global global JJ cord-284627-qvz63m93 28 18 concern concern NN cord-284627-qvz63m93 28 19 in in IN cord-284627-qvz63m93 28 20 Wuhan Wuhan NNP cord-284627-qvz63m93 28 21 , , , cord-284627-qvz63m93 28 22 China China NNP cord-284627-qvz63m93 28 23 from from IN cord-284627-qvz63m93 28 24 the the DT cord-284627-qvz63m93 28 25 menace menace NN cord-284627-qvz63m93 28 26 of of IN cord-284627-qvz63m93 28 27 COVID-19 COVID-19 NNP cord-284627-qvz63m93 28 28 ( ( -LRB- cord-284627-qvz63m93 28 29 nCoV nCoV NNP cord-284627-qvz63m93 28 30 / / SYM cord-284627-qvz63m93 28 31 β β NN cord-284627-qvz63m93 28 32 - - HYPH cord-284627-qvz63m93 28 33 coronavirus coronavirus NN cord-284627-qvz63m93 28 34 ) ) -RRB- cord-284627-qvz63m93 28 35 , , , cord-284627-qvz63m93 28 36 also also RB cord-284627-qvz63m93 28 37 known know VBN cord-284627-qvz63m93 28 38 as as IN cord-284627-qvz63m93 28 39 SARS SARS NNP cord-284627-qvz63m93 28 40 - - HYPH cord-284627-qvz63m93 28 41 CoV-2 CoV-2 NNP cord-284627-qvz63m93 28 42 . . . cord-284627-qvz63m93 29 1 COVID-19 COVID-19 NNP cord-284627-qvz63m93 29 2 is be VBZ cord-284627-qvz63m93 29 3 one one CD cord-284627-qvz63m93 29 4 of of IN cord-284627-qvz63m93 29 5 the the DT cord-284627-qvz63m93 29 6 seven seven CD cord-284627-qvz63m93 29 7 pathogenic pathogenic JJ cord-284627-qvz63m93 29 8 members member NNS cord-284627-qvz63m93 29 9 of of IN cord-284627-qvz63m93 29 10 family family NN cord-284627-qvz63m93 29 11 coronaviridae coronaviridae NNP cord-284627-qvz63m93 29 12 , , , cord-284627-qvz63m93 29 13 other other JJ cord-284627-qvz63m93 29 14 notable notable JJ cord-284627-qvz63m93 29 15 ones one NNS cord-284627-qvz63m93 29 16 are be VBP cord-284627-qvz63m93 29 17 severe severe JJ cord-284627-qvz63m93 29 18 acute acute JJ cord-284627-qvz63m93 29 19 respiratory respiratory JJ cord-284627-qvz63m93 29 20 syndrome syndrome NN cord-284627-qvz63m93 29 21 ( ( -LRB- cord-284627-qvz63m93 29 22 SARS SARS NNP cord-284627-qvz63m93 29 23 ) ) -RRB- cord-284627-qvz63m93 29 24 coronavirus coronavirus NN cord-284627-qvz63m93 29 25 ( ( -LRB- cord-284627-qvz63m93 29 26 SARS SARS NNP cord-284627-qvz63m93 29 27 - - HYPH cord-284627-qvz63m93 29 28 CoV CoV NNP cord-284627-qvz63m93 29 29 ) ) -RRB- cord-284627-qvz63m93 29 30 , , , cord-284627-qvz63m93 29 31 identified identify VBN cord-284627-qvz63m93 29 32 first first RB cord-284627-qvz63m93 29 33 in in IN cord-284627-qvz63m93 29 34 southern southern JJ cord-284627-qvz63m93 29 35 China China NNP cord-284627-qvz63m93 29 36 ( ( -LRB- cord-284627-qvz63m93 29 37 November November NNP cord-284627-qvz63m93 29 38 , , , cord-284627-qvz63m93 29 39 2002 2002 CD cord-284627-qvz63m93 29 40 ) ) -RRB- cord-284627-qvz63m93 29 41 , , , cord-284627-qvz63m93 29 42 and and CC cord-284627-qvz63m93 29 43 Middle Middle NNP cord-284627-qvz63m93 29 44 East East NNP cord-284627-qvz63m93 29 45 respiratory respiratory JJ cord-284627-qvz63m93 29 46 syndrome syndrome NN cord-284627-qvz63m93 29 47 ( ( -LRB- cord-284627-qvz63m93 29 48 MERS MERS NNP cord-284627-qvz63m93 29 49 ) ) -RRB- cord-284627-qvz63m93 29 50 coronavirus coronavirus NN cord-284627-qvz63m93 29 51 ( ( -LRB- cord-284627-qvz63m93 29 52 MERS MERS NNP cord-284627-qvz63m93 29 53 - - HYPH cord-284627-qvz63m93 29 54 CoV CoV NNP cord-284627-qvz63m93 29 55 ) ) -RRB- cord-284627-qvz63m93 29 56 , , , cord-284627-qvz63m93 29 57 from from IN cord-284627-qvz63m93 29 58 Saudi Saudi NNP cord-284627-qvz63m93 29 59 Arabia Arabia NNP cord-284627-qvz63m93 29 60 ( ( -LRB- cord-284627-qvz63m93 29 61 2012 2012 CD cord-284627-qvz63m93 29 62 ) ) -RRB- cord-284627-qvz63m93 29 63 . . . cord-284627-qvz63m93 30 1 Less less RBR cord-284627-qvz63m93 30 2 severe severe JJ cord-284627-qvz63m93 30 3 ones one NNS cord-284627-qvz63m93 30 4 are be VBP cord-284627-qvz63m93 30 5 HKU1 HKU1 NNP cord-284627-qvz63m93 30 6 , , , cord-284627-qvz63m93 30 7 NL63 NL63 NNP cord-284627-qvz63m93 30 8 , , , cord-284627-qvz63m93 30 9 OC-43 OC-43 NNP cord-284627-qvz63m93 30 10 and and CC cord-284627-qvz63m93 30 11 229E. 229e. NN cord-284627-qvz63m93 30 12 1 1 CD cord-284627-qvz63m93 31 1 The the DT cord-284627-qvz63m93 31 2 enveloped envelop VBN cord-284627-qvz63m93 31 3 virus virus NN cord-284627-qvz63m93 31 4 possesses possess VBZ cord-284627-qvz63m93 31 5 crown crown NN cord-284627-qvz63m93 31 6 - - HYPH cord-284627-qvz63m93 31 7 like like JJ cord-284627-qvz63m93 31 8 spikes spike NNS cord-284627-qvz63m93 31 9 on on IN cord-284627-qvz63m93 31 10 their -PRON- PRP$ cord-284627-qvz63m93 31 11 surface surface NN cord-284627-qvz63m93 31 12 ( ( -LRB- cord-284627-qvz63m93 31 13 Latin latin JJ cord-284627-qvz63m93 31 14 word word NN cord-284627-qvz63m93 31 15 corona corona NN cord-284627-qvz63m93 31 16 i.e i.e HYPH cord-284627-qvz63m93 31 17 crown crown NNP cord-284627-qvz63m93 31 18 ) ) -RRB- cord-284627-qvz63m93 31 19 and and CC cord-284627-qvz63m93 31 20 a a DT cord-284627-qvz63m93 31 21 RNA RNA NNP cord-284627-qvz63m93 31 22 genome genome NN cord-284627-qvz63m93 31 23 , , , cord-284627-qvz63m93 31 24 single single JJ cord-284627-qvz63m93 31 25 stranded strand VBN cord-284627-qvz63m93 31 26 positive positive JJ cord-284627-qvz63m93 31 27 - - HYPH cord-284627-qvz63m93 31 28 sense sense NN cord-284627-qvz63m93 31 29 strand strand NN cord-284627-qvz63m93 31 30 with with IN cord-284627-qvz63m93 31 31 26 26 CD cord-284627-qvz63m93 31 32 to to TO cord-284627-qvz63m93 31 33 32 32 CD cord-284627-qvz63m93 31 34 kb kb CD cord-284627-qvz63m93 31 35 length length NN cord-284627-qvz63m93 31 36 . . . cord-284627-qvz63m93 32 1 2 2 LS cord-284627-qvz63m93 33 1 The the DT cord-284627-qvz63m93 33 2 microbe microbe NN cord-284627-qvz63m93 33 3 can can MD cord-284627-qvz63m93 33 4 co co VB cord-284627-qvz63m93 33 5 - - VB cord-284627-qvz63m93 33 6 infect infect VB cord-284627-qvz63m93 33 7 different different JJ cord-284627-qvz63m93 33 8 vertebrates vertebrate NNS cord-284627-qvz63m93 33 9 including include VBG cord-284627-qvz63m93 33 10 humans human NNS cord-284627-qvz63m93 33 11 and and CC cord-284627-qvz63m93 33 12 affect affect VB cord-284627-qvz63m93 33 13 organs organ NNS cord-284627-qvz63m93 33 14 of of IN cord-284627-qvz63m93 33 15 respiratory respiratory JJ cord-284627-qvz63m93 33 16 , , , cord-284627-qvz63m93 33 17 gastrointestinal gastrointestinal JJ cord-284627-qvz63m93 33 18 and and CC cord-284627-qvz63m93 33 19 central central JJ cord-284627-qvz63m93 33 20 nervous nervous JJ cord-284627-qvz63m93 33 21 system system NN cord-284627-qvz63m93 33 22 . . . cord-284627-qvz63m93 34 1 According accord VBG cord-284627-qvz63m93 34 2 to to IN cord-284627-qvz63m93 34 3 World World NNP cord-284627-qvz63m93 34 4 Health Health NNP cord-284627-qvz63m93 34 5 Organization Organization NNP cord-284627-qvz63m93 34 6 ( ( -LRB- cord-284627-qvz63m93 34 7 WHO who WP cord-284627-qvz63m93 34 8 ) ) -RRB- cord-284627-qvz63m93 34 9 , , , cord-284627-qvz63m93 34 10 80 80 CD cord-284627-qvz63m93 34 11 % % NN cord-284627-qvz63m93 34 12 COVID covid JJ cord-284627-qvz63m93 34 13 infection infection NN cord-284627-qvz63m93 34 14 are be VBP cord-284627-qvz63m93 34 15 mild mild JJ cord-284627-qvz63m93 34 16 or or CC cord-284627-qvz63m93 34 17 asymptomatic asymptomatic JJ cord-284627-qvz63m93 34 18 , , , cord-284627-qvz63m93 34 19 15 15 CD cord-284627-qvz63m93 34 20 % % NN cord-284627-qvz63m93 34 21 are be VBP cord-284627-qvz63m93 34 22 severe severe JJ cord-284627-qvz63m93 34 23 infection infection NN cord-284627-qvz63m93 34 24 , , , cord-284627-qvz63m93 34 25 while while IN cord-284627-qvz63m93 34 26 5 5 CD cord-284627-qvz63m93 34 27 % % NN cord-284627-qvz63m93 34 28 are be VBP cord-284627-qvz63m93 34 29 critical critical JJ cord-284627-qvz63m93 34 30 . . . cord-284627-qvz63m93 35 1 Crude crude JJ cord-284627-qvz63m93 35 2 mortality mortality NN cord-284627-qvz63m93 35 3 ratio ratio NN cord-284627-qvz63m93 35 4 ( ( -LRB- cord-284627-qvz63m93 35 5 no no UH cord-284627-qvz63m93 35 6 . . NN cord-284627-qvz63m93 35 7 of of IN cord-284627-qvz63m93 35 8 reported report VBN cord-284627-qvz63m93 35 9 deaths death NNS cord-284627-qvz63m93 35 10 divided divide VBN cord-284627-qvz63m93 35 11 by by IN cord-284627-qvz63m93 35 12 reported report VBN cord-284627-qvz63m93 35 13 cases case NNS cord-284627-qvz63m93 35 14 ) ) -RRB- cord-284627-qvz63m93 35 15 is be VBZ cord-284627-qvz63m93 35 16 between between IN cord-284627-qvz63m93 35 17 3 3 CD cord-284627-qvz63m93 35 18 - - SYM cord-284627-qvz63m93 35 19 4 4 CD cord-284627-qvz63m93 35 20 % % NN cord-284627-qvz63m93 35 21 . . . cord-284627-qvz63m93 36 1 The the DT cord-284627-qvz63m93 36 2 infection infection NN cord-284627-qvz63m93 36 3 mortality mortality NN cord-284627-qvz63m93 36 4 rate rate NN cord-284627-qvz63m93 36 5 ( ( -LRB- cord-284627-qvz63m93 36 6 the the DT cord-284627-qvz63m93 36 7 number number NN cord-284627-qvz63m93 36 8 of of IN cord-284627-qvz63m93 36 9 reported report VBN cord-284627-qvz63m93 36 10 deaths death NNS cord-284627-qvz63m93 36 11 divided divide VBN cord-284627-qvz63m93 36 12 by by IN cord-284627-qvz63m93 36 13 the the DT cord-284627-qvz63m93 36 14 number number NN cord-284627-qvz63m93 36 15 of of IN cord-284627-qvz63m93 36 16 infection infection NN cord-284627-qvz63m93 36 17 ) ) -RRB- cord-284627-qvz63m93 36 18 will will MD cord-284627-qvz63m93 36 19 be be VB cord-284627-qvz63m93 36 20 lower low JJR cord-284627-qvz63m93 36 21 than than IN cord-284627-qvz63m93 36 22 seasonal seasonal JJ cord-284627-qvz63m93 36 23 influenza influenza NN cord-284627-qvz63m93 36 24 ( ( -LRB- cord-284627-qvz63m93 36 25 0·1 0·1 CD cord-284627-qvz63m93 36 26 % % NN cord-284627-qvz63m93 36 27 ) ) -RRB- cord-284627-qvz63m93 36 28 . . . cord-284627-qvz63m93 37 1 Globally globally RB cord-284627-qvz63m93 37 2 there there EX cord-284627-qvz63m93 37 3 are be VBP cord-284627-qvz63m93 37 4 6,68,690 6,68,690 CD cord-284627-qvz63m93 37 5 confirmed confirm VBN cord-284627-qvz63m93 37 6 cases case NNS cord-284627-qvz63m93 37 7 ; ; : cord-284627-qvz63m93 37 8 31,065 31,065 CD cord-284627-qvz63m93 37 9 deaths death NNS cord-284627-qvz63m93 37 10 and and CC cord-284627-qvz63m93 37 11 so so RB cord-284627-qvz63m93 37 12 far far RB cord-284627-qvz63m93 37 13 1,43,107 1,43,107 CD cord-284627-qvz63m93 37 14 people people NNS cord-284627-qvz63m93 37 15 recovered recover VBD cord-284627-qvz63m93 37 16 in in IN cord-284627-qvz63m93 37 17 199 199 CD cord-284627-qvz63m93 37 18 countries country NNS cord-284627-qvz63m93 37 19 and and CC cord-284627-qvz63m93 37 20 territories territory NNS cord-284627-qvz63m93 37 21 . . . cord-284627-qvz63m93 38 1 3 3 LS cord-284627-qvz63m93 38 2 , , , cord-284627-qvz63m93 38 3 4 4 CD cord-284627-qvz63m93 38 4 The the DT cord-284627-qvz63m93 38 5 most most RBS cord-284627-qvz63m93 38 6 vulnerable vulnerable JJ cord-284627-qvz63m93 38 7 group group NN cord-284627-qvz63m93 38 8 in in IN cord-284627-qvz63m93 38 9 corona corona NN cord-284627-qvz63m93 38 10 epidemic epidemic NN cord-284627-qvz63m93 38 11 is be VBZ cord-284627-qvz63m93 38 12 elderly elderly JJ cord-284627-qvz63m93 38 13 , , , cord-284627-qvz63m93 38 14 malnourished malnourished JJ cord-284627-qvz63m93 38 15 , , , cord-284627-qvz63m93 38 16 hypertensive hypertensive JJ cord-284627-qvz63m93 38 17 , , , cord-284627-qvz63m93 38 18 diabetic diabetic JJ cord-284627-qvz63m93 38 19 , , , cord-284627-qvz63m93 38 20 immune immune JJ cord-284627-qvz63m93 38 21 compromised compromise VBN cord-284627-qvz63m93 38 22 , , , cord-284627-qvz63m93 38 23 cancer cancer NN cord-284627-qvz63m93 38 24 and and CC cord-284627-qvz63m93 38 25 cardiovascular cardiovascular JJ cord-284627-qvz63m93 38 26 patients patient NNS cord-284627-qvz63m93 38 27 , , , cord-284627-qvz63m93 38 28 as as RB cord-284627-qvz63m93 38 29 well well RB cord-284627-qvz63m93 38 30 as as IN cord-284627-qvz63m93 38 31 pregnant pregnant JJ cord-284627-qvz63m93 38 32 women woman NNS cord-284627-qvz63m93 38 33 . . . cord-284627-qvz63m93 39 1 Despite despite IN cord-284627-qvz63m93 39 2 wide wide JJ cord-284627-qvz63m93 39 3 spread spread NN cord-284627-qvz63m93 39 4 COVID-19 covid-19 CD cord-284627-qvz63m93 39 5 infection infection NN cord-284627-qvz63m93 39 6 , , , cord-284627-qvz63m93 39 7 the the DT cord-284627-qvz63m93 39 8 numbers number NNS cord-284627-qvz63m93 39 9 of of IN cord-284627-qvz63m93 39 10 fatally fatally RB cord-284627-qvz63m93 39 11 infected infect VBN cord-284627-qvz63m93 39 12 children child NNS cord-284627-qvz63m93 39 13 cases case NNS cord-284627-qvz63m93 39 14 are be VBP cord-284627-qvz63m93 39 15 less less RBR cord-284627-qvz63m93 39 16 reported report VBN cord-284627-qvz63m93 39 17 so so RB cord-284627-qvz63m93 39 18 far far RB cord-284627-qvz63m93 39 19 , , , cord-284627-qvz63m93 39 20 possible possible JJ cord-284627-qvz63m93 39 21 mechanism mechanism NN cord-284627-qvz63m93 39 22 might may MD cord-284627-qvz63m93 39 23 be be VB cord-284627-qvz63m93 39 24 an an DT cord-284627-qvz63m93 39 25 unknown unknown JJ cord-284627-qvz63m93 39 26 protective protective JJ cord-284627-qvz63m93 39 27 interaction interaction NN cord-284627-qvz63m93 39 28 between between IN cord-284627-qvz63m93 39 29 immune immune JJ cord-284627-qvz63m93 39 30 system system NN cord-284627-qvz63m93 39 31 and and CC cord-284627-qvz63m93 39 32 respiratory respiratory JJ cord-284627-qvz63m93 39 33 pathway pathway NN cord-284627-qvz63m93 39 34 . . . cord-284627-qvz63m93 40 1 5 5 LS cord-284627-qvz63m93 40 2 COVID-19 COVID-19 NNP cord-284627-qvz63m93 40 3 spreads spread NNS cord-284627-qvz63m93 40 4 through through IN cord-284627-qvz63m93 40 5 droplet droplet NN cord-284627-qvz63m93 40 6 infection infection NN cord-284627-qvz63m93 40 7 and and CC cord-284627-qvz63m93 40 8 fomites fomite NNS cord-284627-qvz63m93 40 9 , , , cord-284627-qvz63m93 40 10 from from IN cord-284627-qvz63m93 40 11 infected infected JJ cord-284627-qvz63m93 40 12 person person NN cord-284627-qvz63m93 40 13 during during IN cord-284627-qvz63m93 40 14 coughing cough VBG cord-284627-qvz63m93 40 15 and and CC cord-284627-qvz63m93 40 16 sneezing sneezing NN cord-284627-qvz63m93 40 17 . . . cord-284627-qvz63m93 41 1 Majority majority NN cord-284627-qvz63m93 41 2 of of IN cord-284627-qvz63m93 41 3 symptoms symptom NNS cord-284627-qvz63m93 41 4 are be VBP cord-284627-qvz63m93 41 5 sore sore JJ cord-284627-qvz63m93 41 6 throat throat NN cord-284627-qvz63m93 41 7 , , , cord-284627-qvz63m93 41 8 breathing breathe VBG cord-284627-qvz63m93 41 9 difficulty difficulty NN cord-284627-qvz63m93 41 10 and and CC cord-284627-qvz63m93 41 11 fever fever NN cord-284627-qvz63m93 41 12 , , , cord-284627-qvz63m93 41 13 although although IN cord-284627-qvz63m93 41 14 GI GI NNP cord-284627-qvz63m93 41 15 and and CC cord-284627-qvz63m93 41 16 musculoskeletal musculoskeletal JJ cord-284627-qvz63m93 41 17 system system NN cord-284627-qvz63m93 41 18 are be VBP cord-284627-qvz63m93 41 19 also also RB cord-284627-qvz63m93 41 20 involved involve VBN cord-284627-qvz63m93 41 21 . . . cord-284627-qvz63m93 42 1 6,7 6,7 CD cord-284627-qvz63m93 43 1 Clinical clinical JJ cord-284627-qvz63m93 43 2 course course NN cord-284627-qvz63m93 43 3 is be VBZ cord-284627-qvz63m93 43 4 somehow somehow RB cord-284627-qvz63m93 43 5 showing show VBG cord-284627-qvz63m93 43 6 a a DT cord-284627-qvz63m93 43 7 predictable predictable JJ cord-284627-qvz63m93 43 8 pattern pattern NN cord-284627-qvz63m93 43 9 . . . cord-284627-qvz63m93 44 1 On on IN cord-284627-qvz63m93 44 2 around around IN cord-284627-qvz63m93 44 3 day day NN cord-284627-qvz63m93 44 4 five five CD cord-284627-qvz63m93 44 5 , , , cord-284627-qvz63m93 44 6 flu flu NN cord-284627-qvz63m93 44 7 like like IN cord-284627-qvz63m93 44 8 symptom symptom NN cord-284627-qvz63m93 44 9 starts start VBZ cord-284627-qvz63m93 44 10 , , , cord-284627-qvz63m93 44 11 common common JJ cord-284627-qvz63m93 44 12 are be VBP cord-284627-qvz63m93 44 13 fever fever NN cord-284627-qvz63m93 44 14 , , , cord-284627-qvz63m93 44 15 headache headache NN cord-284627-qvz63m93 44 16 , , , cord-284627-qvz63m93 44 17 dry dry JJ cord-284627-qvz63m93 44 18 cough cough NN cord-284627-qvz63m93 44 19 , , , cord-284627-qvz63m93 44 20 myalgia myalgia NN cord-284627-qvz63m93 44 21 ( ( -LRB- cord-284627-qvz63m93 44 22 and and CC cord-284627-qvz63m93 44 23 back back JJ cord-284627-qvz63m93 44 24 pain pain NN cord-284627-qvz63m93 44 25 ) ) -RRB- cord-284627-qvz63m93 44 26 , , , cord-284627-qvz63m93 44 27 nausea nausea NN cord-284627-qvz63m93 44 28 ( ( -LRB- cord-284627-qvz63m93 44 29 without without IN cord-284627-qvz63m93 44 30 vomiting vomit VBG cord-284627-qvz63m93 44 31 ) ) -RRB- cord-284627-qvz63m93 44 32 , , , cord-284627-qvz63m93 44 33 abdominal abdominal JJ cord-284627-qvz63m93 44 34 discomfort discomfort NN cord-284627-qvz63m93 44 35 with with IN cord-284627-qvz63m93 44 36 some some DT cord-284627-qvz63m93 44 37 diarrhea diarrhea NN cord-284627-qvz63m93 44 38 , , , cord-284627-qvz63m93 44 39 loss loss NN cord-284627-qvz63m93 44 40 of of IN cord-284627-qvz63m93 44 41 smell smell NN cord-284627-qvz63m93 44 42 , , , cord-284627-qvz63m93 44 43 anorexia anorexia NN cord-284627-qvz63m93 44 44 and and CC cord-284627-qvz63m93 44 45 fatigue fatigue NN cord-284627-qvz63m93 44 46 . . . cord-284627-qvz63m93 45 1 Around around IN cord-284627-qvz63m93 45 2 same same JJ cord-284627-qvz63m93 45 3 time time NN cord-284627-qvz63m93 45 4 symptoms symptom NNS cord-284627-qvz63m93 45 5 can can MD cord-284627-qvz63m93 45 6 worsen worsen VB cord-284627-qvz63m93 45 7 leading lead VBG cord-284627-qvz63m93 45 8 to to IN cord-284627-qvz63m93 45 9 shortness shortness NN cord-284627-qvz63m93 45 10 of of IN cord-284627-qvz63m93 45 11 breath breath NN cord-284627-qvz63m93 45 12 due due IN cord-284627-qvz63m93 45 13 to to IN cord-284627-qvz63m93 45 14 bilateral bilateral JJ cord-284627-qvz63m93 45 15 viral viral JJ cord-284627-qvz63m93 45 16 pneumonia pneumonia NN cord-284627-qvz63m93 45 17 from from IN cord-284627-qvz63m93 45 18 direct direct JJ cord-284627-qvz63m93 45 19 viral viral JJ cord-284627-qvz63m93 45 20 damage damage NN cord-284627-qvz63m93 45 21 to to IN cord-284627-qvz63m93 45 22 lung lung NN cord-284627-qvz63m93 45 23 parenchyma parenchyma NN cord-284627-qvz63m93 45 24 . . . cord-284627-qvz63m93 46 1 Around around IN cord-284627-qvz63m93 46 2 day10 day10 CD cord-284627-qvz63m93 46 3 , , , cord-284627-qvz63m93 46 4 cytokine cytokine NN cord-284627-qvz63m93 46 5 storm storm NN cord-284627-qvz63m93 46 6 kicks kick VBZ cord-284627-qvz63m93 46 7 in in RP cord-284627-qvz63m93 46 8 , , , cord-284627-qvz63m93 46 9 subsequently subsequently RB cord-284627-qvz63m93 46 10 acute acute JJ cord-284627-qvz63m93 46 11 respiratory respiratory JJ cord-284627-qvz63m93 46 12 distress distress NN cord-284627-qvz63m93 46 13 syndrome syndrome NN cord-284627-qvz63m93 46 14 ( ( -LRB- cord-284627-qvz63m93 46 15 ARDS ARDS NNP cord-284627-qvz63m93 46 16 ) ) -RRB- cord-284627-qvz63m93 46 17 and and CC cord-284627-qvz63m93 46 18 multi multi JJ cord-284627-qvz63m93 46 19 organ organ NN cord-284627-qvz63m93 46 20 failure failure NN cord-284627-qvz63m93 46 21 ensues ensue VBZ cord-284627-qvz63m93 46 22 . . . cord-284627-qvz63m93 47 1 This this DT cord-284627-qvz63m93 47 2 degradation degradation NN cord-284627-qvz63m93 47 3 usually usually RB cord-284627-qvz63m93 47 4 happens happen VBZ cord-284627-qvz63m93 47 5 in in IN cord-284627-qvz63m93 47 6 matter matter NN cord-284627-qvz63m93 47 7 of of IN cord-284627-qvz63m93 47 8 hours hour NNS cord-284627-qvz63m93 47 9 . . . cord-284627-qvz63m93 48 1 Hospitalized hospitalize VBN cord-284627-qvz63m93 48 2 patients patient NNS cord-284627-qvz63m93 48 3 in in IN cord-284627-qvz63m93 48 4 moderate moderate JJ cord-284627-qvz63m93 48 5 to to IN cord-284627-qvz63m93 48 6 severe severe JJ cord-284627-qvz63m93 48 7 cases case NNS cord-284627-qvz63m93 48 8 usually usually RB cord-284627-qvz63m93 48 9 come come VBP cord-284627-qvz63m93 48 10 in in IN cord-284627-qvz63m93 48 11 hypoxic hypoxic JJ cord-284627-qvz63m93 48 12 stage stage NN cord-284627-qvz63m93 48 13 without without IN cord-284627-qvz63m93 48 14 dyspnea dyspnea NN cord-284627-qvz63m93 48 15 . . . cord-284627-qvz63m93 49 1 China China NNP cord-284627-qvz63m93 49 2 reported report VBD cord-284627-qvz63m93 49 3 15 15 CD cord-284627-qvz63m93 49 4 % % NN cord-284627-qvz63m93 49 5 cardiac cardiac JJ cord-284627-qvz63m93 49 6 involvement involvement NN cord-284627-qvz63m93 49 7 and and CC cord-284627-qvz63m93 49 8 serious serious JJ cord-284627-qvz63m93 49 9 final final JJ cord-284627-qvz63m93 49 10 outcome outcome NN cord-284627-qvz63m93 49 11 . . . cord-284627-qvz63m93 50 1 In in IN cord-284627-qvz63m93 50 2 most most JJS cord-284627-qvz63m93 50 3 of of IN cord-284627-qvz63m93 50 4 the the DT cord-284627-qvz63m93 50 5 chest chest NN cord-284627-qvz63m93 50 6 X X NNS cord-284627-qvz63m93 50 7 - - NNS cord-284627-qvz63m93 50 8 rays ray NNS cord-284627-qvz63m93 50 9 , , , cord-284627-qvz63m93 50 10 bilateral bilateral JJ cord-284627-qvz63m93 50 11 interstitial interstitial JJ cord-284627-qvz63m93 50 12 pneumonia pneumonia NN cord-284627-qvz63m93 50 13 or or CC cord-284627-qvz63m93 50 14 ground ground NN cord-284627-qvz63m93 50 15 glass glass NN cord-284627-qvz63m93 50 16 opacities opacity NNS cord-284627-qvz63m93 50 17 are be VBP cord-284627-qvz63m93 50 18 seen see VBN cord-284627-qvz63m93 50 19 . . . cord-284627-qvz63m93 51 1 Hypoxia hypoxia NN cord-284627-qvz63m93 51 2 mostly mostly RB cord-284627-qvz63m93 51 3 does do VBZ cord-284627-qvz63m93 51 4 not not RB cord-284627-qvz63m93 51 5 correlate correlate VB cord-284627-qvz63m93 51 6 well well RB cord-284627-qvz63m93 51 7 with with IN cord-284627-qvz63m93 51 8 the the DT cord-284627-qvz63m93 51 9 chest chest NN cord-284627-qvz63m93 51 10 x x NN cord-284627-qvz63m93 51 11 - - NN cord-284627-qvz63m93 51 12 ray ray NN cord-284627-qvz63m93 51 13 findings finding NNS cord-284627-qvz63m93 51 14 . . . cord-284627-qvz63m93 52 1 Chest chest NN cord-284627-qvz63m93 52 2 auscultations auscultation NNS cord-284627-qvz63m93 52 3 are be VBP cord-284627-qvz63m93 52 4 not not RB cord-284627-qvz63m93 52 5 of of IN cord-284627-qvz63m93 52 6 great great JJ cord-284627-qvz63m93 52 7 help help NN cord-284627-qvz63m93 52 8 . . . cord-284627-qvz63m93 53 1 Blood blood NN cord-284627-qvz63m93 53 2 reports report NNS cord-284627-qvz63m93 53 3 show show VBP cord-284627-qvz63m93 53 4 , , , cord-284627-qvz63m93 53 5 in in IN cord-284627-qvz63m93 53 6 the the DT cord-284627-qvz63m93 53 7 most most JJS cord-284627-qvz63m93 53 8 cases case NNS cord-284627-qvz63m93 53 9 , , , cord-284627-qvz63m93 53 10 WBC WBC NNP cord-284627-qvz63m93 53 11 is be VBZ cord-284627-qvz63m93 53 12 low low JJ cord-284627-qvz63m93 53 13 , , , cord-284627-qvz63m93 53 14 i.e. i.e. FW cord-284627-qvz63m93 53 15 mostly mostly RB cord-284627-qvz63m93 53 16 lymphocytopenia lymphocytopenia NNP cord-284627-qvz63m93 53 17 , , , cord-284627-qvz63m93 53 18 low low JJ cord-284627-qvz63m93 53 19 platelet platelet NN cord-284627-qvz63m93 53 20 count count NN cord-284627-qvz63m93 53 21 whereas whereas IN cord-284627-qvz63m93 53 22 pro pro JJ cord-284627-qvz63m93 53 23 - - JJ cord-284627-qvz63m93 53 24 calcitonin calcitonin JJ cord-284627-qvz63m93 53 25 are be VBP cord-284627-qvz63m93 53 26 mostly mostly RB cord-284627-qvz63m93 53 27 normal normal JJ cord-284627-qvz63m93 53 28 . . . cord-284627-qvz63m93 54 1 Most most RBS cord-284627-qvz63m93 54 2 consistently consistently RB cord-284627-qvz63m93 54 3 , , , cord-284627-qvz63m93 54 4 CRP CRP NNP cord-284627-qvz63m93 54 5 and and CC cord-284627-qvz63m93 54 6 ferritin ferritin NN cord-284627-qvz63m93 54 7 levels level NNS cord-284627-qvz63m93 54 8 are be VBP cord-284627-qvz63m93 54 9 elevated elevate VBN cord-284627-qvz63m93 54 10 and and CC cord-284627-qvz63m93 54 11 similarly similarly RB cord-284627-qvz63m93 54 12 CPK CPK NNP cord-284627-qvz63m93 54 13 , , , cord-284627-qvz63m93 54 14 D d NN cord-284627-qvz63m93 54 15 - - HYPH cord-284627-qvz63m93 54 16 dimer dimer NN cord-284627-qvz63m93 54 17 , , , cord-284627-qvz63m93 54 18 LDH LDH NNP cord-284627-qvz63m93 54 19 , , , cord-284627-qvz63m93 54 20 ALKphos ALKphos NNP cord-284627-qvz63m93 54 21 / / SYM cord-284627-qvz63m93 54 22 AST AST NNP cord-284627-qvz63m93 54 23 - - HYPH cord-284627-qvz63m93 54 24 ALT alt NN cord-284627-qvz63m93 54 25 levels level NNS cord-284627-qvz63m93 54 26 are be VBP cord-284627-qvz63m93 54 27 also also RB cord-284627-qvz63m93 54 28 high high JJ cord-284627-qvz63m93 54 29 . . . cord-284627-qvz63m93 55 1 It -PRON- PRP cord-284627-qvz63m93 55 2 has have VBZ cord-284627-qvz63m93 55 3 been be VBN cord-284627-qvz63m93 55 4 seen see VBN cord-284627-qvz63m93 55 5 a a DT cord-284627-qvz63m93 55 6 ratio ratio NN cord-284627-qvz63m93 55 7 of of IN cord-284627-qvz63m93 55 8 absolute absolute JJ cord-284627-qvz63m93 55 9 neutrophil neutrophil NN cord-284627-qvz63m93 55 10 count count NN cord-284627-qvz63m93 55 11 to to IN cord-284627-qvz63m93 55 12 absolute absolute JJ cord-284627-qvz63m93 55 13 lymphocyte lymphocyte NN cord-284627-qvz63m93 55 14 count count NN cord-284627-qvz63m93 55 15 , , , cord-284627-qvz63m93 55 16 greater great JJR cord-284627-qvz63m93 55 17 than than IN cord-284627-qvz63m93 55 18 3.5 3.5 CD cord-284627-qvz63m93 55 19 , , , cord-284627-qvz63m93 55 20 may may MD cord-284627-qvz63m93 55 21 be be VB cord-284627-qvz63m93 55 22 the the DT cord-284627-qvz63m93 55 23 highest high JJS cord-284627-qvz63m93 55 24 predictor predictor NN cord-284627-qvz63m93 55 25 of of IN cord-284627-qvz63m93 55 26 poor poor JJ cord-284627-qvz63m93 55 27 outcome outcome NN cord-284627-qvz63m93 55 28 . . . cord-284627-qvz63m93 56 1 An an DT cord-284627-qvz63m93 56 2 elevated elevated JJ cord-284627-qvz63m93 56 3 level level NN cord-284627-qvz63m93 56 4 of of IN cord-284627-qvz63m93 56 5 IL-6 IL-6 NNP cord-284627-qvz63m93 56 6 is be VBZ cord-284627-qvz63m93 56 7 of of IN cord-284627-qvz63m93 56 8 grave grave JJ cord-284627-qvz63m93 56 9 concern concern NN cord-284627-qvz63m93 56 10 of of IN cord-284627-qvz63m93 56 11 cytokine cytokine NN cord-284627-qvz63m93 56 12 storm storm NN cord-284627-qvz63m93 56 13 . . . cord-284627-qvz63m93 57 1 8,9 8,9 CD cord-284627-qvz63m93 58 1 Among among IN cord-284627-qvz63m93 58 2 the the DT cord-284627-qvz63m93 58 3 four four CD cord-284627-qvz63m93 58 4 classified classify VBN cord-284627-qvz63m93 58 5 subfamilies subfamily NNS cord-284627-qvz63m93 58 6 , , , cord-284627-qvz63m93 58 7 α α NN cord-284627-qvz63m93 58 8 -and -and CC cord-284627-qvz63m93 58 9 β β NN cord-284627-qvz63m93 58 10 -coronaviruses -coronaviruses : cord-284627-qvz63m93 58 11 both both DT cord-284627-qvz63m93 58 12 were be VBD cord-284627-qvz63m93 58 13 found find VBN cord-284627-qvz63m93 58 14 in in IN cord-284627-qvz63m93 58 15 bats bat NNS cord-284627-qvz63m93 58 16 , , , cord-284627-qvz63m93 58 17 e.g e.g NNP cord-284627-qvz63m93 58 18 Leafnose Leafnose NNP cord-284627-qvz63m93 58 19 bats bat NNS cord-284627-qvz63m93 58 20 like like IN cord-284627-qvz63m93 58 21 Hipposideros Hipposideros NNP cord-284627-qvz63m93 58 22 armige armige NNP cord-284627-qvz63m93 58 23 harbor harbor NN cord-284627-qvz63m93 58 24 α α NNP cord-284627-qvz63m93 58 25 -coronavirus -coronavirus CD cord-284627-qvz63m93 58 26 and and CC cord-284627-qvz63m93 58 27 β β NN cord-284627-qvz63m93 58 28 -coronavirus -coronavirus CD cord-284627-qvz63m93 58 29 in in IN cord-284627-qvz63m93 58 30 Hipposideros Hipposideros NNP cord-284627-qvz63m93 58 31 larvatus larvatus NN cord-284627-qvz63m93 58 32 ; ; : cord-284627-qvz63m93 59 1 10 10 CD cord-284627-qvz63m93 59 2 while while IN cord-284627-qvz63m93 59 3 γ γ NN cord-284627-qvz63m93 59 4 -and -and : cord-284627-qvz63m93 60 1 δ δ LS cord-284627-qvz63m93 60 2 -coronavirus -coronavirus CD cord-284627-qvz63m93 60 3 found find VBN cord-284627-qvz63m93 60 4 in in IN cord-284627-qvz63m93 60 5 pigs pig NNS cord-284627-qvz63m93 60 6 and and CC cord-284627-qvz63m93 60 7 birds bird NNS cord-284627-qvz63m93 60 8 respectively respectively RB cord-284627-qvz63m93 60 9 . . . cord-284627-qvz63m93 61 1 11 11 CD cord-284627-qvz63m93 62 1 The the DT cord-284627-qvz63m93 62 2 genesis genesis NN cord-284627-qvz63m93 62 3 of of IN cord-284627-qvz63m93 62 4 β β NNP cord-284627-qvz63m93 62 5 coronavirus coronavirus NN cord-284627-qvz63m93 62 6 cluster cluster NN cord-284627-qvz63m93 62 7 in in IN cord-284627-qvz63m93 62 8 afore afore RB cord-284627-qvz63m93 62 9 mentioned mention VBN cord-284627-qvz63m93 62 10 bat bat NN cord-284627-qvz63m93 62 11 species specie NNS cord-284627-qvz63m93 62 12 , , , cord-284627-qvz63m93 62 13 consisting consist VBG cord-284627-qvz63m93 62 14 of of IN cord-284627-qvz63m93 62 15 primeval primeval JJ cord-284627-qvz63m93 62 16 and and CC cord-284627-qvz63m93 62 17 genetically genetically RB cord-284627-qvz63m93 62 18 independent independent JJ cord-284627-qvz63m93 62 19 types type NNS cord-284627-qvz63m93 62 20 might may MD cord-284627-qvz63m93 62 21 took take VBD cord-284627-qvz63m93 62 22 favour favour NN cord-284627-qvz63m93 62 23 of of IN cord-284627-qvz63m93 62 24 host host NN cord-284627-qvz63m93 62 25 / / SYM cord-284627-qvz63m93 62 26 pathogen pathogen NN cord-284627-qvz63m93 62 27 interaction interaction NN cord-284627-qvz63m93 62 28 despite despite IN cord-284627-qvz63m93 62 29 of of IN cord-284627-qvz63m93 62 30 wide wide JJ cord-284627-qvz63m93 62 31 geographical geographical JJ cord-284627-qvz63m93 62 32 distribution distribution NN cord-284627-qvz63m93 62 33 . . . cord-284627-qvz63m93 63 1 10 10 CD cord-284627-qvz63m93 63 2 Genomic genomic JJ cord-284627-qvz63m93 63 3 characterization characterization NN cord-284627-qvz63m93 63 4 of of IN cord-284627-qvz63m93 63 5 SARS SARS NNP cord-284627-qvz63m93 63 6 - - HYPH cord-284627-qvz63m93 63 7 CoV-2 CoV-2 NNP cord-284627-qvz63m93 63 8 reveals reveal VBZ cord-284627-qvz63m93 63 9 96 96 CD cord-284627-qvz63m93 63 10 % % NN cord-284627-qvz63m93 63 11 identity identity NN cord-284627-qvz63m93 63 12 to to IN cord-284627-qvz63m93 63 13 that that DT cord-284627-qvz63m93 63 14 of of IN cord-284627-qvz63m93 63 15 bat bat NN cord-284627-qvz63m93 63 16 coronavirus coronavirus NN cord-284627-qvz63m93 63 17 whole whole JJ cord-284627-qvz63m93 63 18 genome genome NN cord-284627-qvz63m93 63 19 ; ; : cord-284627-qvz63m93 63 20 1 1 CD cord-284627-qvz63m93 63 21 while while IN cord-284627-qvz63m93 63 22 79 79 CD cord-284627-qvz63m93 63 23 % % NN cord-284627-qvz63m93 63 24 and and CC cord-284627-qvz63m93 63 25 50 50 CD cord-284627-qvz63m93 63 26 % % NN cord-284627-qvz63m93 63 27 to to IN cord-284627-qvz63m93 63 28 that that DT cord-284627-qvz63m93 63 29 of of IN cord-284627-qvz63m93 63 30 SARS SARS NNP cord-284627-qvz63m93 63 31 - - HYPH cord-284627-qvz63m93 63 32 CoV CoV NNP cord-284627-qvz63m93 63 33 and and CC cord-284627-qvz63m93 63 34 MERS MERS NNP cord-284627-qvz63m93 63 35 - - HYPH cord-284627-qvz63m93 63 36 CoV CoV NNP cord-284627-qvz63m93 63 37 respectively respectively RB cord-284627-qvz63m93 63 38 . . . cord-284627-qvz63m93 64 1 12 12 CD cord-284627-qvz63m93 65 1 Like like IN cord-284627-qvz63m93 65 2 other other JJ cord-284627-qvz63m93 65 3 betacoronaviruses betacoronaviruse NNS cord-284627-qvz63m93 65 4 , , , cord-284627-qvz63m93 65 5 the the DT cord-284627-qvz63m93 65 6 genome genome NN cord-284627-qvz63m93 65 7 of of IN cord-284627-qvz63m93 65 8 SARS SARS NNP cord-284627-qvz63m93 65 9 - - HYPH cord-284627-qvz63m93 65 10 CoV-2 CoV-2 NNP cord-284627-qvz63m93 65 11 has have VBZ cord-284627-qvz63m93 65 12 a a DT cord-284627-qvz63m93 65 13 long long JJ cord-284627-qvz63m93 65 14 ORF1ab ORF1ab NNP cord-284627-qvz63m93 65 15 polyprotein polyprotein NN cord-284627-qvz63m93 65 16 at at IN cord-284627-qvz63m93 65 17 the the DT cord-284627-qvz63m93 65 18 5 5 CD cord-284627-qvz63m93 65 19 ' ' NN cord-284627-qvz63m93 65 20 end end NN cord-284627-qvz63m93 65 21 , , , cord-284627-qvz63m93 65 22 followed follow VBN cord-284627-qvz63m93 65 23 by by IN cord-284627-qvz63m93 65 24 four four CD cord-284627-qvz63m93 65 25 major major JJ cord-284627-qvz63m93 65 26 structural structural JJ cord-284627-qvz63m93 65 27 proteins protein NNS cord-284627-qvz63m93 65 28 , , , cord-284627-qvz63m93 65 29 including include VBG cord-284627-qvz63m93 65 30 the the DT cord-284627-qvz63m93 65 31 spike spike NN cord-284627-qvz63m93 65 32 like like IN cord-284627-qvz63m93 65 33 surface surface NN cord-284627-qvz63m93 65 34 glycoprotein glycoprotein NN cord-284627-qvz63m93 65 35 , , , cord-284627-qvz63m93 65 36 small small JJ cord-284627-qvz63m93 65 37 envelope envelope NN cord-284627-qvz63m93 65 38 protein protein NN cord-284627-qvz63m93 65 39 , , , cord-284627-qvz63m93 65 40 matrix matrix NN cord-284627-qvz63m93 65 41 protein protein NN cord-284627-qvz63m93 65 42 , , , cord-284627-qvz63m93 65 43 and and CC cord-284627-qvz63m93 65 44 nucleocapsid nucleocapsid NN cord-284627-qvz63m93 65 45 protein protein NN cord-284627-qvz63m93 65 46 . . . cord-284627-qvz63m93 66 1 11 11 CD cord-284627-qvz63m93 66 2 , , , cord-284627-qvz63m93 66 3 13 13 CD cord-284627-qvz63m93 67 1 The the DT cord-284627-qvz63m93 67 2 spike spike NN cord-284627-qvz63m93 67 3 ( ( -LRB- cord-284627-qvz63m93 67 4 S s NN cord-284627-qvz63m93 67 5 ) ) -RRB- cord-284627-qvz63m93 67 6 protein protein NN cord-284627-qvz63m93 67 7 has have VBZ cord-284627-qvz63m93 67 8 two two CD cord-284627-qvz63m93 67 9 distinct distinct JJ cord-284627-qvz63m93 67 10 functional functional JJ cord-284627-qvz63m93 67 11 domains domain NNS cord-284627-qvz63m93 67 12 , , , cord-284627-qvz63m93 67 13 termed term VBD cord-284627-qvz63m93 67 14 S1 S1 NNP cord-284627-qvz63m93 67 15 and and CC cord-284627-qvz63m93 67 16 S2 S2 NNP cord-284627-qvz63m93 67 17 , , , cord-284627-qvz63m93 67 18 both both DT cord-284627-qvz63m93 67 19 of of IN cord-284627-qvz63m93 67 20 which which WDT cord-284627-qvz63m93 67 21 are be VBP cord-284627-qvz63m93 67 22 necessary necessary JJ cord-284627-qvz63m93 67 23 for for IN cord-284627-qvz63m93 67 24 a a DT cord-284627-qvz63m93 67 25 coronavirus coronavirus NN cord-284627-qvz63m93 67 26 to to TO cord-284627-qvz63m93 67 27 successfully successfully RB cord-284627-qvz63m93 67 28 enter enter VB cord-284627-qvz63m93 67 29 a a DT cord-284627-qvz63m93 67 30 cell cell NN cord-284627-qvz63m93 67 31 . . . cord-284627-qvz63m93 68 1 It -PRON- PRP cord-284627-qvz63m93 68 2 has have VBZ cord-284627-qvz63m93 68 3 been be VBN cord-284627-qvz63m93 68 4 found find VBN cord-284627-qvz63m93 68 5 that that IN cord-284627-qvz63m93 68 6 S s NN cord-284627-qvz63m93 68 7 protein protein NN cord-284627-qvz63m93 68 8 of of IN cord-284627-qvz63m93 68 9 SARS SARS NNP cord-284627-qvz63m93 68 10 - - HYPH cord-284627-qvz63m93 68 11 CoV-2 CoV-2 NNP cord-284627-qvz63m93 68 12 is be VBZ cord-284627-qvz63m93 68 13 10 10 CD cord-284627-qvz63m93 68 14 - - SYM cord-284627-qvz63m93 68 15 20 20 CD cord-284627-qvz63m93 68 16 times time NNS cord-284627-qvz63m93 68 17 more more RBR cord-284627-qvz63m93 68 18 likely likely JJ cord-284627-qvz63m93 68 19 to to TO cord-284627-qvz63m93 68 20 bind bind VB cord-284627-qvz63m93 68 21 to to IN cord-284627-qvz63m93 68 22 human human JJ cord-284627-qvz63m93 68 23 ACE2 ACE2 NNP cord-284627-qvz63m93 68 24 than than IN cord-284627-qvz63m93 68 25 the the DT cord-284627-qvz63m93 68 26 S S NNP cord-284627-qvz63m93 68 27 protein protein NN cord-284627-qvz63m93 68 28 of of IN cord-284627-qvz63m93 68 29 the the DT cord-284627-qvz63m93 68 30 early early JJ cord-284627-qvz63m93 68 31 2000s 2000 NNS cord-284627-qvz63m93 68 32 SARS SARS NNP cord-284627-qvz63m93 68 33 - - HYPH cord-284627-qvz63m93 68 34 CoV CoV NNP cord-284627-qvz63m93 68 35 strain strain NN cord-284627-qvz63m93 68 36 . . . cord-284627-qvz63m93 69 1 ACE2 ACE2 NNP cord-284627-qvz63m93 69 2 is be VBZ cord-284627-qvz63m93 69 3 essentially essentially RB cord-284627-qvz63m93 69 4 a a DT cord-284627-qvz63m93 69 5 carboxypeptidase carboxypeptidase NN cord-284627-qvz63m93 69 6 , , , cord-284627-qvz63m93 69 7 which which WDT cord-284627-qvz63m93 69 8 can can MD cord-284627-qvz63m93 69 9 remove remove VB cord-284627-qvz63m93 69 10 carboxy carboxy JJ cord-284627-qvz63m93 69 11 - - HYPH cord-284627-qvz63m93 69 12 terminal terminal NN cord-284627-qvz63m93 69 13 of of IN cord-284627-qvz63m93 69 14 hydrophobic hydrophobic JJ cord-284627-qvz63m93 69 15 or or CC cord-284627-qvz63m93 69 16 basic basic JJ cord-284627-qvz63m93 69 17 amino amino NN cord-284627-qvz63m93 69 18 acids acid NNS cord-284627-qvz63m93 69 19 . . . cord-284627-qvz63m93 70 1 The the DT cord-284627-qvz63m93 70 2 expression expression NN cord-284627-qvz63m93 70 3 of of IN cord-284627-qvz63m93 70 4 ACE2 ACE2 NNP cord-284627-qvz63m93 70 5 is be VBZ cord-284627-qvz63m93 70 6 comparatively comparatively RB cord-284627-qvz63m93 70 7 higher high JJR cord-284627-qvz63m93 70 8 in in IN cord-284627-qvz63m93 70 9 mouth mouth NN cord-284627-qvz63m93 70 10 and and CC cord-284627-qvz63m93 70 11 tongue tongue NN cord-284627-qvz63m93 70 12 and and CC cord-284627-qvz63m93 70 13 is be VBZ cord-284627-qvz63m93 70 14 also also RB cord-284627-qvz63m93 70 15 normally normally RB cord-284627-qvz63m93 70 16 expressed express VBN cord-284627-qvz63m93 70 17 in in IN cord-284627-qvz63m93 70 18 human human JJ cord-284627-qvz63m93 70 19 lower low JJR cord-284627-qvz63m93 70 20 lungs lung NNS cord-284627-qvz63m93 70 21 on on IN cord-284627-qvz63m93 70 22 type type NN cord-284627-qvz63m93 70 23 - - : cord-284627-qvz63m93 70 24 I i NN cord-284627-qvz63m93 70 25 and and CC cord-284627-qvz63m93 70 26 type type NN cord-284627-qvz63m93 70 27 - - HYPH cord-284627-qvz63m93 70 28 II ii CD cord-284627-qvz63m93 70 29 alveolar alveolar NN cord-284627-qvz63m93 70 30 epithelial epithelial JJ cord-284627-qvz63m93 70 31 cells cell NNS cord-284627-qvz63m93 70 32 . . . cord-284627-qvz63m93 71 1 The the DT cord-284627-qvz63m93 71 2 heightened heightened JJ cord-284627-qvz63m93 71 3 affinity affinity NN cord-284627-qvz63m93 71 4 for for IN cord-284627-qvz63m93 71 5 a a DT cord-284627-qvz63m93 71 6 prevalent prevalent JJ cord-284627-qvz63m93 71 7 cellular cellular JJ cord-284627-qvz63m93 71 8 receptor receptor NN cord-284627-qvz63m93 71 9 may may MD cord-284627-qvz63m93 71 10 be be VB cord-284627-qvz63m93 71 11 a a DT cord-284627-qvz63m93 71 12 factor factor NN cord-284627-qvz63m93 71 13 which which WDT cord-284627-qvz63m93 71 14 increases increase VBZ cord-284627-qvz63m93 71 15 a a DT cord-284627-qvz63m93 71 16 quick quick JJ cord-284627-qvz63m93 71 17 transmission transmission NN cord-284627-qvz63m93 71 18 of of IN cord-284627-qvz63m93 71 19 SARS SARS NNP cord-284627-qvz63m93 71 20 - - HYPH cord-284627-qvz63m93 71 21 CoV-2 CoV-2 NNP cord-284627-qvz63m93 71 22 in in IN cord-284627-qvz63m93 71 23 the the DT cord-284627-qvz63m93 71 24 upper upper JJ cord-284627-qvz63m93 71 25 respiratory respiratory JJ cord-284627-qvz63m93 71 26 tract tract NN cord-284627-qvz63m93 71 27 . . . cord-284627-qvz63m93 72 1 As as IN cord-284627-qvz63m93 72 2 an an DT cord-284627-qvz63m93 72 3 RNA RNA NNP cord-284627-qvz63m93 72 4 virus virus NN cord-284627-qvz63m93 72 5 , , , cord-284627-qvz63m93 72 6 2019-nCoV 2019-ncov ADD cord-284627-qvz63m93 72 7 has have VBZ cord-284627-qvz63m93 72 8 the the DT cord-284627-qvz63m93 72 9 inherent inherent JJ cord-284627-qvz63m93 72 10 feature feature NN cord-284627-qvz63m93 72 11 of of IN cord-284627-qvz63m93 72 12 a a DT cord-284627-qvz63m93 72 13 high high JJ cord-284627-qvz63m93 72 14 mutation mutation NN cord-284627-qvz63m93 72 15 rate rate NN cord-284627-qvz63m93 72 16 . . . cord-284627-qvz63m93 73 1 Due due IN cord-284627-qvz63m93 73 2 to to IN cord-284627-qvz63m93 73 3 mutations mutation NNS cord-284627-qvz63m93 73 4 and and CC cord-284627-qvz63m93 73 5 recombination recombination NN cord-284627-qvz63m93 73 6 effects effect NNS cord-284627-qvz63m93 73 7 , , , cord-284627-qvz63m93 73 8 different different JJ cord-284627-qvz63m93 73 9 viral viral JJ cord-284627-qvz63m93 73 10 strains strain NNS cord-284627-qvz63m93 73 11 are be VBP cord-284627-qvz63m93 73 12 originating originate VBG cord-284627-qvz63m93 73 13 with with IN cord-284627-qvz63m93 73 14 new new JJ cord-284627-qvz63m93 73 15 characteristics characteristic NNS cord-284627-qvz63m93 73 16 ; ; : cord-284627-qvz63m93 73 17 however however RB cord-284627-qvz63m93 73 18 because because IN cord-284627-qvz63m93 73 19 of of IN cord-284627-qvz63m93 73 20 its -PRON- PRP$ cord-284627-qvz63m93 73 21 genome genome NN cord-284627-qvz63m93 73 22 encoded encode VBN cord-284627-qvz63m93 73 23 exonuclease exonuclease NN cord-284627-qvz63m93 73 24 , , , cord-284627-qvz63m93 73 25 the the DT cord-284627-qvz63m93 73 26 mutation mutation NN cord-284627-qvz63m93 73 27 rate rate NN cord-284627-qvz63m93 73 28 might may MD cord-284627-qvz63m93 73 29 be be VB cord-284627-qvz63m93 73 30 somewhat somewhat RB cord-284627-qvz63m93 73 31 lower low JJR cord-284627-qvz63m93 73 32 than than IN cord-284627-qvz63m93 73 33 other other JJ cord-284627-qvz63m93 73 34 RNA RNA NNP cord-284627-qvz63m93 73 35 viruses virus NNS cord-284627-qvz63m93 73 36 . . . cord-284627-qvz63m93 74 1 12 12 CD cord-284627-qvz63m93 74 2 , , , cord-284627-qvz63m93 74 3 14 14 CD cord-284627-qvz63m93 74 4 In in IN cord-284627-qvz63m93 74 5 this this DT cord-284627-qvz63m93 74 6 study study NN cord-284627-qvz63m93 74 7 , , , cord-284627-qvz63m93 74 8 we -PRON- PRP cord-284627-qvz63m93 74 9 comprehensively comprehensively RB cord-284627-qvz63m93 74 10 analyzed analyze VBD cord-284627-qvz63m93 74 11 the the DT cord-284627-qvz63m93 74 12 whole whole JJ cord-284627-qvz63m93 74 13 genome genome NN cord-284627-qvz63m93 74 14 sequence sequence NN cord-284627-qvz63m93 74 15 homology homology NN cord-284627-qvz63m93 74 16 from from IN cord-284627-qvz63m93 74 17 the the DT cord-284627-qvz63m93 74 18 available available JJ cord-284627-qvz63m93 74 19 patient patient NN cord-284627-qvz63m93 74 20 data datum NNS cord-284627-qvz63m93 74 21 uploaded upload VBN cord-284627-qvz63m93 74 22 by by IN cord-284627-qvz63m93 74 23 affected affected JJ cord-284627-qvz63m93 74 24 countries country NNS cord-284627-qvz63m93 74 25 in in IN cord-284627-qvz63m93 74 26 NCBI NCBI NNP cord-284627-qvz63m93 74 27 Virus Virus NNP cord-284627-qvz63m93 74 28 database database NN cord-284627-qvz63m93 74 29 , , , cord-284627-qvz63m93 74 30 identified identify VBD cord-284627-qvz63m93 74 31 the the DT cord-284627-qvz63m93 74 32 mutations mutation NNS cord-284627-qvz63m93 74 33 developed develop VBN cord-284627-qvz63m93 74 34 by by IN cord-284627-qvz63m93 74 35 different different JJ cord-284627-qvz63m93 74 36 strains strain NNS cord-284627-qvz63m93 74 37 from from IN cord-284627-qvz63m93 74 38 the the DT cord-284627-qvz63m93 74 39 ancestor ancestor NN cord-284627-qvz63m93 74 40 strain strain NN cord-284627-qvz63m93 74 41 and and CC cord-284627-qvz63m93 74 42 studied study VBD cord-284627-qvz63m93 74 43 the the DT cord-284627-qvz63m93 74 44 impact impact NN cord-284627-qvz63m93 74 45 of of IN cord-284627-qvz63m93 74 46 those those DT cord-284627-qvz63m93 74 47 mutations mutation NNS cord-284627-qvz63m93 74 48 at at IN cord-284627-qvz63m93 74 49 functional functional JJ cord-284627-qvz63m93 74 50 level level NN cord-284627-qvz63m93 74 51 . . . cord-284627-qvz63m93 75 1 Our -PRON- PRP$ cord-284627-qvz63m93 75 2 endeavour endeavour NN cord-284627-qvz63m93 75 3 was be VBD cord-284627-qvz63m93 75 4 to to TO cord-284627-qvz63m93 75 5 categorize categorize VB cord-284627-qvz63m93 75 6 all all PDT cord-284627-qvz63m93 75 7 the the DT cord-284627-qvz63m93 75 8 strains strain NNS cord-284627-qvz63m93 75 9 into into IN cord-284627-qvz63m93 75 10 major major JJ cord-284627-qvz63m93 75 11 groups group NNS cord-284627-qvz63m93 75 12 depending depend VBG cord-284627-qvz63m93 75 13 upon upon IN cord-284627-qvz63m93 75 14 their -PRON- PRP$ cord-284627-qvz63m93 75 15 lethal lethal JJ cord-284627-qvz63m93 75 16 effect effect NN cord-284627-qvz63m93 75 17 and and CC cord-284627-qvz63m93 75 18 mutations mutation NNS cord-284627-qvz63m93 75 19 observed observe VBD cord-284627-qvz63m93 75 20 . . . cord-284627-qvz63m93 76 1 Whole whole JJ cord-284627-qvz63m93 76 2 genomic genomic JJ cord-284627-qvz63m93 76 3 data data NN cord-284627-qvz63m93 76 4 retrieval retrieval NN cord-284627-qvz63m93 76 5 from from IN cord-284627-qvz63m93 76 6 the the DT cord-284627-qvz63m93 76 7 database database NN cord-284627-qvz63m93 76 8 Retrieved retrieve VBD cord-284627-qvz63m93 76 9 the the DT cord-284627-qvz63m93 76 10 whole whole JJ cord-284627-qvz63m93 76 11 genome genome NN cord-284627-qvz63m93 76 12 sequences sequence NNS cord-284627-qvz63m93 76 13 from from IN cord-284627-qvz63m93 76 14 " " `` cord-284627-qvz63m93 76 15 NCBI NCBI NNP cord-284627-qvz63m93 76 16 Virus Virus NNP cord-284627-qvz63m93 76 17 " " '' cord-284627-qvz63m93 76 18 database database NN cord-284627-qvz63m93 76 19 , , , cord-284627-qvz63m93 76 20 specific specific JJ cord-284627-qvz63m93 76 21 input input NN cord-284627-qvz63m93 76 22 was be VBD cord-284627-qvz63m93 76 23 " " `` cord-284627-qvz63m93 76 24 SARS SARS NNP cord-284627-qvz63m93 76 25 - - HYPH cord-284627-qvz63m93 76 26 CoV-2 CoV-2 NNP cord-284627-qvz63m93 76 27 " " '' cord-284627-qvz63m93 76 28 , , , cord-284627-qvz63m93 76 29 during during IN cord-284627-qvz63m93 76 30 a a DT cord-284627-qvz63m93 76 31 period period NN cord-284627-qvz63m93 76 32 from from IN cord-284627-qvz63m93 76 33 Jan Jan NNP cord-284627-qvz63m93 76 34 5 5 CD cord-284627-qvz63m93 76 35 through through IN cord-284627-qvz63m93 76 36 March March NNP cord-284627-qvz63m93 76 37 24 24 CD cord-284627-qvz63m93 76 38 , , , cord-284627-qvz63m93 76 39 2020 2020 CD cord-284627-qvz63m93 76 40 . . . cord-284627-qvz63m93 77 1 Later later JJ cord-284627-qvz63m93 77 2 submissions submission NNS cord-284627-qvz63m93 77 3 or or CC cord-284627-qvz63m93 77 4 the the DT cord-284627-qvz63m93 77 5 sequences sequence NNS cord-284627-qvz63m93 77 6 with with IN cord-284627-qvz63m93 77 7 many many JJ cord-284627-qvz63m93 77 8 undetermined undetermined JJ cord-284627-qvz63m93 77 9 nucleotides nucleotide NNS cord-284627-qvz63m93 77 10 ( ( -LRB- cord-284627-qvz63m93 77 11 denoted denote VBN cord-284627-qvz63m93 77 12 as as IN cord-284627-qvz63m93 77 13 N n CD cord-284627-qvz63m93 77 14 ) ) -RRB- cord-284627-qvz63m93 77 15 were be VBD cord-284627-qvz63m93 77 16 not not RB cord-284627-qvz63m93 77 17 considered consider VBN cord-284627-qvz63m93 77 18 . . . cord-284627-qvz63m93 78 1 15 15 CD cord-284627-qvz63m93 78 2 Countries country NNS cord-284627-qvz63m93 78 3 those those DT cord-284627-qvz63m93 78 4 had have VBD cord-284627-qvz63m93 78 5 multiple multiple JJ cord-284627-qvz63m93 78 6 entries entry NNS cord-284627-qvz63m93 78 7 , , , cord-284627-qvz63m93 78 8 highest high JJS cord-284627-qvz63m93 78 9 number number NN cord-284627-qvz63m93 78 10 of of IN cord-284627-qvz63m93 78 11 entries entry NNS cord-284627-qvz63m93 78 12 with with IN cord-284627-qvz63m93 78 13 whole whole JJ cord-284627-qvz63m93 78 14 genome genome NN cord-284627-qvz63m93 78 15 sequence sequence NN cord-284627-qvz63m93 78 16 were be VBD cord-284627-qvz63m93 78 17 matched match VBN cord-284627-qvz63m93 78 18 for for IN cord-284627-qvz63m93 78 19 identifying identify VBG cord-284627-qvz63m93 78 20 representative representative JJ cord-284627-qvz63m93 78 21 sequence sequence NN cord-284627-qvz63m93 78 22 to to TO cord-284627-qvz63m93 78 23 consider consider VB cord-284627-qvz63m93 78 24 ( ( -LRB- cord-284627-qvz63m93 78 25 e.g. e.g. RB cord-284627-qvz63m93 78 26 for for IN cord-284627-qvz63m93 78 27 USA USA NNP cord-284627-qvz63m93 78 28 , , , cord-284627-qvz63m93 78 29 out out IN cord-284627-qvz63m93 78 30 of of IN cord-284627-qvz63m93 78 31 44 44 CD cord-284627-qvz63m93 78 32 submitted submit VBN cord-284627-qvz63m93 78 33 complete complete JJ cord-284627-qvz63m93 78 34 genomic genomic JJ cord-284627-qvz63m93 78 35 sequences sequence NNS cord-284627-qvz63m93 78 36 , , , cord-284627-qvz63m93 78 37 the the DT cord-284627-qvz63m93 78 38 sequence sequence NN cord-284627-qvz63m93 78 39 with with IN cord-284627-qvz63m93 78 40 29 29 CD cord-284627-qvz63m93 78 41 submissions submission NNS cord-284627-qvz63m93 78 42 were be VBD cord-284627-qvz63m93 78 43 of of IN cord-284627-qvz63m93 78 44 complete complete JJ cord-284627-qvz63m93 78 45 genomic genomic JJ cord-284627-qvz63m93 78 46 sequence sequence NN cord-284627-qvz63m93 78 47 with with IN cord-284627-qvz63m93 78 48 100 100 CD cord-284627-qvz63m93 78 49 % % NN cord-284627-qvz63m93 78 50 identity identity NN cord-284627-qvz63m93 78 51 and and CC cord-284627-qvz63m93 78 52 thus thus RB cord-284627-qvz63m93 78 53 one one CD cord-284627-qvz63m93 78 54 representative representative JJ cord-284627-qvz63m93 78 55 sequence sequence NN cord-284627-qvz63m93 78 56 was be VBD cord-284627-qvz63m93 78 57 considered consider VBN cord-284627-qvz63m93 78 58 for for IN cord-284627-qvz63m93 78 59 the the DT cord-284627-qvz63m93 78 60 present present JJ cord-284627-qvz63m93 78 61 study study NN cord-284627-qvz63m93 78 62 ) ) -RRB- cord-284627-qvz63m93 78 63 . . . cord-284627-qvz63m93 79 1 Thus thus RB cord-284627-qvz63m93 79 2 , , , cord-284627-qvz63m93 79 3 13 13 CD cord-284627-qvz63m93 79 4 complete complete JJ cord-284627-qvz63m93 79 5 whole whole JJ cord-284627-qvz63m93 79 6 genome genome NN cord-284627-qvz63m93 79 7 sequences sequence NNS cord-284627-qvz63m93 79 8 submitted submit VBN cord-284627-qvz63m93 79 9 by by IN cord-284627-qvz63m93 79 10 13 13 CD cord-284627-qvz63m93 79 11 different different JJ cord-284627-qvz63m93 79 12 affected affect VBN cord-284627-qvz63m93 79 13 countries country NNS cord-284627-qvz63m93 79 14 were be VBD cord-284627-qvz63m93 79 15 taken take VBN cord-284627-qvz63m93 79 16 into into IN cord-284627-qvz63m93 79 17 consideration consideration NN cord-284627-qvz63m93 79 18 ( ( -LRB- cord-284627-qvz63m93 79 19 figure figure NN cord-284627-qvz63m93 79 20 1 1 CD cord-284627-qvz63m93 79 21 ) ) -RRB- cord-284627-qvz63m93 79 22 . . . cord-284627-qvz63m93 80 1 ClustalW ClustalW NNP cord-284627-qvz63m93 80 2 ( ( -LRB- cord-284627-qvz63m93 80 3 version version NN cord-284627-qvz63m93 80 4 2.1 2.1 CD cord-284627-qvz63m93 80 5 ) ) -RRB- cord-284627-qvz63m93 80 6 was be VBD cord-284627-qvz63m93 80 7 employed employ VBN cord-284627-qvz63m93 80 8 to to TO cord-284627-qvz63m93 80 9 align align VB cord-284627-qvz63m93 80 10 multiple multiple JJ cord-284627-qvz63m93 80 11 sequences sequence NNS cord-284627-qvz63m93 80 12 , , , cord-284627-qvz63m93 80 13 representative representative NN cord-284627-qvz63m93 80 14 of of IN cord-284627-qvz63m93 80 15 13 13 CD cord-284627-qvz63m93 80 16 countries country NNS cord-284627-qvz63m93 80 17 , , , cord-284627-qvz63m93 80 18 with with IN cord-284627-qvz63m93 80 19 the the DT cord-284627-qvz63m93 80 20 purpose purpose NN cord-284627-qvz63m93 80 21 ( ( -LRB- cord-284627-qvz63m93 80 22 a a LS cord-284627-qvz63m93 80 23 ) ) -RRB- cord-284627-qvz63m93 80 24 to to TO cord-284627-qvz63m93 80 25 understand understand VB cord-284627-qvz63m93 80 26 the the DT cord-284627-qvz63m93 80 27 similarity similarity NN cord-284627-qvz63m93 80 28 and and CC cord-284627-qvz63m93 80 29 variation variation NN cord-284627-qvz63m93 80 30 in in IN cord-284627-qvz63m93 80 31 all all DT cord-284627-qvz63m93 80 32 genomic genomic JJ cord-284627-qvz63m93 80 33 position position NN cord-284627-qvz63m93 80 34 , , , cord-284627-qvz63m93 80 35 ( ( -LRB- cord-284627-qvz63m93 80 36 b b NN cord-284627-qvz63m93 80 37 ) ) -RRB- cord-284627-qvz63m93 80 38 to to TO cord-284627-qvz63m93 80 39 establish establish VB cord-284627-qvz63m93 80 40 the the DT cord-284627-qvz63m93 80 41 evolutionary evolutionary JJ cord-284627-qvz63m93 80 42 relationship relationship NN cord-284627-qvz63m93 80 43 among among IN cord-284627-qvz63m93 80 44 the the DT cord-284627-qvz63m93 80 45 viral viral JJ cord-284627-qvz63m93 80 46 strains strain NNS cord-284627-qvz63m93 80 47 affecting affect VBG cord-284627-qvz63m93 80 48 the the DT cord-284627-qvz63m93 80 49 whole whole JJ cord-284627-qvz63m93 80 50 world world NN cord-284627-qvz63m93 80 51 and and CC cord-284627-qvz63m93 80 52 ( ( -LRB- cord-284627-qvz63m93 80 53 c c NN cord-284627-qvz63m93 80 54 ) ) -RRB- cord-284627-qvz63m93 80 55 finally finally RB cord-284627-qvz63m93 80 56 , , , cord-284627-qvz63m93 80 57 to to TO cord-284627-qvz63m93 80 58 distinguish distinguish VB cord-284627-qvz63m93 80 59 the the DT cord-284627-qvz63m93 80 60 ancestry ancestry NN cord-284627-qvz63m93 80 61 of of IN cord-284627-qvz63m93 80 62 different different JJ cord-284627-qvz63m93 80 63 viral viral JJ cord-284627-qvz63m93 80 64 strains strain NNS cord-284627-qvz63m93 80 65 using use VBG cord-284627-qvz63m93 80 66 FastTree FastTree NNP cord-284627-qvz63m93 80 67 tool tool NN cord-284627-qvz63m93 80 68 , , , cord-284627-qvz63m93 80 69 which which WDT cord-284627-qvz63m93 80 70 is be VBZ cord-284627-qvz63m93 80 71 based base VBN cord-284627-qvz63m93 80 72 on on IN cord-284627-qvz63m93 80 73 Neighbour Neighbour NNP cord-284627-qvz63m93 80 74 joining joining NN cord-284627-qvz63m93 80 75 method method NN cord-284627-qvz63m93 80 76 . . . cord-284627-qvz63m93 81 1 Pair pair JJ cord-284627-qvz63m93 81 2 - - HYPH cord-284627-qvz63m93 81 3 wise wise JJ cord-284627-qvz63m93 81 4 Sequence sequence NN cord-284627-qvz63m93 81 5 Alignment Alignment NNP cord-284627-qvz63m93 81 6 EMBOSS EMBOSS NNP cord-284627-qvz63m93 81 7 - - HYPH cord-284627-qvz63m93 81 8 Stretcher Stretcher NNP cord-284627-qvz63m93 81 9 was be VBD cord-284627-qvz63m93 81 10 used use VBN cord-284627-qvz63m93 81 11 for for IN cord-284627-qvz63m93 81 12 whole whole JJ cord-284627-qvz63m93 81 13 genomic genomic JJ cord-284627-qvz63m93 81 14 pair pair NN cord-284627-qvz63m93 81 15 - - HYPH cord-284627-qvz63m93 81 16 wise wise JJ cord-284627-qvz63m93 81 17 alignment alignment NN cord-284627-qvz63m93 81 18 between between IN cord-284627-qvz63m93 81 19 the the DT cord-284627-qvz63m93 81 20 ancestor ancestor NN cord-284627-qvz63m93 81 21 SARS SARS NNP cord-284627-qvz63m93 81 22 - - HYPH cord-284627-qvz63m93 81 23 CoV-2 CoV-2 NNP cord-284627-qvz63m93 81 24 sequences sequence NNS cord-284627-qvz63m93 81 25 of of IN cord-284627-qvz63m93 81 26 Wuhan Wuhan NNP cord-284627-qvz63m93 81 27 ( ( -LRB- cord-284627-qvz63m93 81 28 NC045512.2 NC045512.2 NNP cord-284627-qvz63m93 81 29 ; ; : cord-284627-qvz63m93 81 30 submitted submit VBN cord-284627-qvz63m93 81 31 on on IN cord-284627-qvz63m93 81 32 5 5 CD cord-284627-qvz63m93 81 33 th th XX cord-284627-qvz63m93 81 34 Jan Jan NNP cord-284627-qvz63m93 81 35 , , , cord-284627-qvz63m93 81 36 2020 2020 CD cord-284627-qvz63m93 81 37 ) ) -RRB- cord-284627-qvz63m93 81 38 with with IN cord-284627-qvz63m93 81 39 all all DT cord-284627-qvz63m93 81 40 13 13 CD cord-284627-qvz63m93 81 41 sequences sequence NNS cord-284627-qvz63m93 81 42 . . . cord-284627-qvz63m93 82 1 Similar similar JJ cord-284627-qvz63m93 82 2 strategy strategy NN cord-284627-qvz63m93 82 3 was be VBD cord-284627-qvz63m93 82 4 used use VBN cord-284627-qvz63m93 82 5 for for IN cord-284627-qvz63m93 82 6 pair pair VB cord-284627-qvz63m93 82 7 wise wise JJ cord-284627-qvz63m93 82 8 alignment alignment NN cord-284627-qvz63m93 82 9 between between IN cord-284627-qvz63m93 82 10 the the DT cord-284627-qvz63m93 82 11 genome genome NN cord-284627-qvz63m93 82 12 sequences sequence NNS cord-284627-qvz63m93 82 13 of of IN cord-284627-qvz63m93 82 14 SARS SARS NNP cord-284627-qvz63m93 82 15 - - HYPH cord-284627-qvz63m93 82 16 CoV CoV NNP cord-284627-qvz63m93 82 17 submitted submit VBN cord-284627-qvz63m93 82 18 by by IN cord-284627-qvz63m93 82 19 Italy Italy NNP cord-284627-qvz63m93 82 20 , , , cord-284627-qvz63m93 82 21 2003 2003 CD cord-284627-qvz63m93 82 22 with with IN cord-284627-qvz63m93 82 23 the the DT cord-284627-qvz63m93 82 24 SARS SARS NNP cord-284627-qvz63m93 82 25 - - HYPH cord-284627-qvz63m93 82 26 CoV-2 CoV-2 NNP cord-284627-qvz63m93 82 27 strain strain NN cord-284627-qvz63m93 82 28 of of IN cord-284627-qvz63m93 82 29 Italy Italy NNP cord-284627-qvz63m93 82 30 , , , cord-284627-qvz63m93 82 31 2020 2020 CD cord-284627-qvz63m93 82 32 . . . cord-284627-qvz63m93 83 1 All all DT cord-284627-qvz63m93 83 2 alignment alignment NN cord-284627-qvz63m93 83 3 results result NNS cord-284627-qvz63m93 83 4 were be VBD cord-284627-qvz63m93 83 5 thoroughly thoroughly RB cord-284627-qvz63m93 83 6 screened screen VBN cord-284627-qvz63m93 83 7 to to TO cord-284627-qvz63m93 83 8 find find VB cord-284627-qvz63m93 83 9 out out RP cord-284627-qvz63m93 83 10 the the DT cord-284627-qvz63m93 83 11 exact exact JJ cord-284627-qvz63m93 83 12 location location NN cord-284627-qvz63m93 83 13 of of IN cord-284627-qvz63m93 83 14 the the DT cord-284627-qvz63m93 83 15 mutations mutation NNS cord-284627-qvz63m93 83 16 and and CC cord-284627-qvz63m93 83 17 the the DT cord-284627-qvz63m93 83 18 genetic genetic JJ cord-284627-qvz63m93 83 19 variation variation NN cord-284627-qvz63m93 83 20 affecting affect VBG cord-284627-qvz63m93 83 21 that that DT cord-284627-qvz63m93 83 22 position position NN cord-284627-qvz63m93 83 23 . . . cord-284627-qvz63m93 84 1 Functional functional JJ cord-284627-qvz63m93 84 2 implications implication NNS cord-284627-qvz63m93 84 3 of of IN cord-284627-qvz63m93 84 4 each each DT cord-284627-qvz63m93 84 5 type type NN cord-284627-qvz63m93 84 6 of of IN cord-284627-qvz63m93 84 7 nucleotide nucleotide JJ cord-284627-qvz63m93 84 8 variations variation NNS cord-284627-qvz63m93 84 9 were be VBD cord-284627-qvz63m93 84 10 understood understand VBN cord-284627-qvz63m93 84 11 from from IN cord-284627-qvz63m93 84 12 the the DT cord-284627-qvz63m93 84 13 LODS LODS NNP cord-284627-qvz63m93 84 14 ratio ratio NN cord-284627-qvz63m93 84 15 and and CC cord-284627-qvz63m93 84 16 it -PRON- PRP cord-284627-qvz63m93 84 17 is be VBZ cord-284627-qvz63m93 84 18 calculated calculate VBN cord-284627-qvz63m93 84 19 by by IN cord-284627-qvz63m93 84 20 the the DT cord-284627-qvz63m93 84 21 formulae formula NNS cord-284627-qvz63m93 84 22 log log NN cord-284627-qvz63m93 84 23 e e NN cord-284627-qvz63m93 84 24 ( ( -LRB- cord-284627-qvz63m93 84 25 Obs Obs NNP cord-284627-qvz63m93 84 26 / / SYM cord-284627-qvz63m93 84 27 Exp Exp NNP cord-284627-qvz63m93 84 28 ) ) -RRB- cord-284627-qvz63m93 84 29 , , , cord-284627-qvz63m93 84 30 where where WRB cord-284627-qvz63m93 84 31 ' ' `` cord-284627-qvz63m93 84 32 Obs Obs NNP cord-284627-qvz63m93 84 33 ' ' '' cord-284627-qvz63m93 84 34 is be VBZ cord-284627-qvz63m93 84 35 the the DT cord-284627-qvz63m93 84 36 observed observed JJ cord-284627-qvz63m93 84 37 frequency frequency NN cord-284627-qvz63m93 84 38 of of IN cord-284627-qvz63m93 84 39 a a DT cord-284627-qvz63m93 84 40 specific specific JJ cord-284627-qvz63m93 84 41 alteration alteration NN cord-284627-qvz63m93 84 42 in in IN cord-284627-qvz63m93 84 43 the the DT cord-284627-qvz63m93 84 44 genome genome NN cord-284627-qvz63m93 84 45 and and CC cord-284627-qvz63m93 84 46 ' ' `` cord-284627-qvz63m93 84 47 Exp Exp NNP cord-284627-qvz63m93 84 48 ' ' '' cord-284627-qvz63m93 84 49 is be VBZ cord-284627-qvz63m93 84 50 the the DT cord-284627-qvz63m93 84 51 expected expect VBN cord-284627-qvz63m93 84 52 frequency frequency NN cord-284627-qvz63m93 84 53 of of IN cord-284627-qvz63m93 84 54 that that DT cord-284627-qvz63m93 84 55 specific specific JJ cord-284627-qvz63m93 84 56 alteration alteration NN cord-284627-qvz63m93 84 57 due due IN cord-284627-qvz63m93 84 58 to to IN cord-284627-qvz63m93 84 59 individual individual JJ cord-284627-qvz63m93 84 60 proportion proportion NN cord-284627-qvz63m93 84 61 of of IN cord-284627-qvz63m93 84 62 the the DT cord-284627-qvz63m93 84 63 nucleotides nucleotide NNS cord-284627-qvz63m93 84 64 in in IN cord-284627-qvz63m93 84 65 the the DT cord-284627-qvz63m93 84 66 genome genome NN cord-284627-qvz63m93 84 67 sequences sequence NNS cord-284627-qvz63m93 84 68 . . . cord-284627-qvz63m93 85 1 To to TO cord-284627-qvz63m93 85 2 obtain obtain VB cord-284627-qvz63m93 85 3 the the DT cord-284627-qvz63m93 85 4 different different JJ cord-284627-qvz63m93 85 5 protein protein NN cord-284627-qvz63m93 85 6 sequences sequence NNS cord-284627-qvz63m93 85 7 of of IN cord-284627-qvz63m93 85 8 the the DT cord-284627-qvz63m93 85 9 translated translate VBN cord-284627-qvz63m93 85 10 genome genome NN cord-284627-qvz63m93 85 11 , , , cord-284627-qvz63m93 85 12 open open JJ cord-284627-qvz63m93 85 13 reading reading NN cord-284627-qvz63m93 85 14 frame frame NN cord-284627-qvz63m93 85 15 was be VBD cord-284627-qvz63m93 85 16 generated generate VBN cord-284627-qvz63m93 85 17 using use VBG cord-284627-qvz63m93 85 18 ORF ORF NNP cord-284627-qvz63m93 85 19 Finder Finder NNP cord-284627-qvz63m93 85 20 . . . cord-284627-qvz63m93 86 1 Six six CD cord-284627-qvz63m93 86 2 different different JJ cord-284627-qvz63m93 86 3 ORF ORF NNP cord-284627-qvz63m93 86 4 were be VBD cord-284627-qvz63m93 86 5 generated generate VBN cord-284627-qvz63m93 86 6 which which WDT cord-284627-qvz63m93 86 7 covered cover VBD cord-284627-qvz63m93 86 8 the the DT cord-284627-qvz63m93 86 9 entire entire JJ cord-284627-qvz63m93 86 10 genome genome NN cord-284627-qvz63m93 86 11 sequence sequence NN cord-284627-qvz63m93 86 12 . . . cord-284627-qvz63m93 87 1 Our -PRON- PRP$ cord-284627-qvz63m93 87 2 protein protein NN cord-284627-qvz63m93 87 3 sequences sequence NNS cord-284627-qvz63m93 87 4 were be VBD cord-284627-qvz63m93 87 5 aligned align VBN cord-284627-qvz63m93 87 6 with with IN cord-284627-qvz63m93 87 7 existing exist VBG cord-284627-qvz63m93 87 8 protein protein NN cord-284627-qvz63m93 87 9 sequences sequence NNS cord-284627-qvz63m93 87 10 of of IN cord-284627-qvz63m93 87 11 SARS SARS NNP cord-284627-qvz63m93 87 12 - - HYPH cord-284627-qvz63m93 87 13 CoV-2 CoV-2 NNP cord-284627-qvz63m93 87 14 present present NN cord-284627-qvz63m93 87 15 in in IN cord-284627-qvz63m93 87 16 the the DT cord-284627-qvz63m93 87 17 ' ' `` cord-284627-qvz63m93 87 18 NCBI NCBI NNP cord-284627-qvz63m93 87 19 Virus Virus NNP cord-284627-qvz63m93 87 20 ' ' '' cord-284627-qvz63m93 87 21 database database NN cord-284627-qvz63m93 87 22 to to TO cord-284627-qvz63m93 87 23 check check VB cord-284627-qvz63m93 87 24 which which WDT cord-284627-qvz63m93 87 25 ORF ORF NNP cord-284627-qvz63m93 87 26 corresponds correspond VBZ cord-284627-qvz63m93 87 27 to to IN cord-284627-qvz63m93 87 28 the the DT cord-284627-qvz63m93 87 29 which which WDT cord-284627-qvz63m93 87 30 known know VBN cord-284627-qvz63m93 87 31 protein protein NN cord-284627-qvz63m93 87 32 . . . cord-284627-qvz63m93 88 1 The the DT cord-284627-qvz63m93 88 2 amino amino NN cord-284627-qvz63m93 88 3 acid acid NN cord-284627-qvz63m93 88 4 alterations alteration NNS cord-284627-qvz63m93 88 5 were be VBD cord-284627-qvz63m93 88 6 identified identify VBN cord-284627-qvz63m93 88 7 from from IN cord-284627-qvz63m93 88 8 the the DT cord-284627-qvz63m93 88 9 nucleotide nucleotide JJ cord-284627-qvz63m93 88 10 information information NN cord-284627-qvz63m93 88 11 and and CC cord-284627-qvz63m93 88 12 were be VBD cord-284627-qvz63m93 88 13 classified classify VBN cord-284627-qvz63m93 88 14 into into IN cord-284627-qvz63m93 88 15 Synonymous Synonymous NNP cord-284627-qvz63m93 88 16 ( ( -LRB- cord-284627-qvz63m93 88 17 S S NNP cord-284627-qvz63m93 88 18 ) ) -RRB- cord-284627-qvz63m93 88 19 and and CC cord-284627-qvz63m93 88 20 Non Non NNP cord-284627-qvz63m93 88 21 Synonymous Synonymous NNP cord-284627-qvz63m93 88 22 ( ( -LRB- cord-284627-qvz63m93 88 23 NS NS NNP cord-284627-qvz63m93 88 24 ) ) -RRB- cord-284627-qvz63m93 88 25 . . . cord-284627-qvz63m93 89 1 The the DT cord-284627-qvz63m93 89 2 functional functional JJ cord-284627-qvz63m93 89 3 impacts impact NNS cord-284627-qvz63m93 89 4 of of IN cord-284627-qvz63m93 89 5 all all DT cord-284627-qvz63m93 89 6 NS NS NNP cord-284627-qvz63m93 89 7 mutations mutation NNS cord-284627-qvz63m93 89 8 at at IN cord-284627-qvz63m93 89 9 protein protein NN cord-284627-qvz63m93 89 10 were be VBD cord-284627-qvz63m93 89 11 analysed analyse VBN cord-284627-qvz63m93 89 12 using use VBG cord-284627-qvz63m93 89 13 different different JJ cord-284627-qvz63m93 89 14 SNP SNP NNP cord-284627-qvz63m93 89 15 annotation annotation NN cord-284627-qvz63m93 89 16 tools tool NNS cord-284627-qvz63m93 89 17 ( ( -LRB- cord-284627-qvz63m93 89 18 i.e. i.e. FW cord-284627-qvz63m93 89 19 SIFT sift VB cord-284627-qvz63m93 89 20 , , , cord-284627-qvz63m93 89 21 SNAP snap VB cord-284627-qvz63m93 89 22 , , , cord-284627-qvz63m93 89 23 Polyphen2 Polyphen2 NNP cord-284627-qvz63m93 89 24 and and CC cord-284627-qvz63m93 89 25 MetaSNP MetaSNP NNP cord-284627-qvz63m93 89 26 ) ) -RRB- cord-284627-qvz63m93 89 27 . . . cord-284627-qvz63m93 90 1 The the DT cord-284627-qvz63m93 90 2 fatality fatality NN cord-284627-qvz63m93 90 3 rate rate NN cord-284627-qvz63m93 90 4 of of IN cord-284627-qvz63m93 90 5 a a DT cord-284627-qvz63m93 90 6 country country NN cord-284627-qvz63m93 90 7 was be VBD cord-284627-qvz63m93 90 8 calculated calculate VBN cord-284627-qvz63m93 90 9 considering consider VBG cord-284627-qvz63m93 90 10 the the DT cord-284627-qvz63m93 90 11 summation summation NN cord-284627-qvz63m93 90 12 of of IN cord-284627-qvz63m93 90 13 total total JJ cord-284627-qvz63m93 90 14 number number NN cord-284627-qvz63m93 90 15 of of IN cord-284627-qvz63m93 90 16 death death NN cord-284627-qvz63m93 90 17 and and CC cord-284627-qvz63m93 90 18 critical critical JJ cord-284627-qvz63m93 90 19 case case NN cord-284627-qvz63m93 90 20 and and CC cord-284627-qvz63m93 90 21 then then RB cord-284627-qvz63m93 90 22 dividing divide VBG cord-284627-qvz63m93 90 23 the the DT cord-284627-qvz63m93 90 24 same same JJ cord-284627-qvz63m93 90 25 with with IN cord-284627-qvz63m93 90 26 total total JJ cord-284627-qvz63m93 90 27 number number NN cord-284627-qvz63m93 90 28 of of IN cord-284627-qvz63m93 90 29 detected detect VBN cord-284627-qvz63m93 90 30 case case NN cord-284627-qvz63m93 90 31 . . . cord-284627-qvz63m93 91 1 [ [ -LRB- cord-284627-qvz63m93 91 2 Fatality fatality NN cord-284627-qvz63m93 91 3 rate rate NN cord-284627-qvz63m93 91 4 = = NFP cord-284627-qvz63m93 92 1 ( ( -LRB- cord-284627-qvz63m93 92 2 Total total VB cord-284627-qvz63m93 92 3 no no NN cord-284627-qvz63m93 92 4 . . . cord-284627-qvz63m93 93 1 of of IN cord-284627-qvz63m93 93 2 deaths death NNS cord-284627-qvz63m93 93 3 + + CC cord-284627-qvz63m93 93 4 total total VBP cord-284627-qvz63m93 93 5 no no DT cord-284627-qvz63m93 93 6 of of IN cord-284627-qvz63m93 93 7 Severe severe JJ cord-284627-qvz63m93 93 8 cases)/ cases)/ : cord-284627-qvz63m93 93 9 Total total VBP cord-284627-qvz63m93 93 10 no no NN cord-284627-qvz63m93 93 11 . . NN cord-284627-qvz63m93 93 12 of of IN cord-284627-qvz63m93 93 13 detected detect VBN cord-284627-qvz63m93 93 14 cases case NNS cord-284627-qvz63m93 93 15 ] ] -RRB- cord-284627-qvz63m93 93 16 ) ) -RRB- cord-284627-qvz63m93 93 17 . . . cord-284627-qvz63m93 94 1 The the DT cord-284627-qvz63m93 94 2 fatality fatality NN cord-284627-qvz63m93 94 3 rates rate NNS cord-284627-qvz63m93 94 4 were be VBD cord-284627-qvz63m93 94 5 matched match VBN cord-284627-qvz63m93 94 6 against against IN cord-284627-qvz63m93 94 7 the the DT cord-284627-qvz63m93 94 8 rarity rarity NN cord-284627-qvz63m93 94 9 of of IN cord-284627-qvz63m93 94 10 the the DT cord-284627-qvz63m93 94 11 nucleotide nucleotide JJ cord-284627-qvz63m93 94 12 alterations alteration NNS cord-284627-qvz63m93 94 13 and and CC cord-284627-qvz63m93 94 14 functional functional JJ cord-284627-qvz63m93 94 15 impact impact NN cord-284627-qvz63m93 94 16 of of IN cord-284627-qvz63m93 94 17 the the DT cord-284627-qvz63m93 94 18 Nonsynonymous Nonsynonymous NNP cord-284627-qvz63m93 94 19 changes change NNS cord-284627-qvz63m93 94 20 at at IN cord-284627-qvz63m93 94 21 protein protein NN cord-284627-qvz63m93 94 22 level level NN cord-284627-qvz63m93 94 23 . . . cord-284627-qvz63m93 95 1 All all PDT cord-284627-qvz63m93 95 2 the the DT cord-284627-qvz63m93 95 3 13 13 CD cord-284627-qvz63m93 95 4 Strains strain NNS cord-284627-qvz63m93 95 5 of of IN cord-284627-qvz63m93 95 6 13 13 CD cord-284627-qvz63m93 95 7 different different JJ cord-284627-qvz63m93 95 8 geographical geographical JJ cord-284627-qvz63m93 95 9 locations location NNS cord-284627-qvz63m93 95 10 were be VBD cord-284627-qvz63m93 95 11 categorized categorize VBN cord-284627-qvz63m93 95 12 depending depend VBG cord-284627-qvz63m93 95 13 upon upon IN cord-284627-qvz63m93 95 14 the the DT cord-284627-qvz63m93 95 15 no no NN cord-284627-qvz63m93 95 16 of of IN cord-284627-qvz63m93 95 17 mutations mutation NNS cord-284627-qvz63m93 95 18 and and CC cord-284627-qvz63m93 95 19 type type NN cord-284627-qvz63m93 95 20 of of IN cord-284627-qvz63m93 95 21 mutations mutation NNS cord-284627-qvz63m93 95 22 they -PRON- PRP cord-284627-qvz63m93 95 23 had have VBD cord-284627-qvz63m93 95 24 . . . cord-284627-qvz63m93 96 1 Multiple multiple JJ cord-284627-qvz63m93 96 2 sequence sequence NN cord-284627-qvz63m93 96 3 alignment alignment NN cord-284627-qvz63m93 96 4 of of IN cord-284627-qvz63m93 96 5 13 13 CD cord-284627-qvz63m93 96 6 whole whole JJ cord-284627-qvz63m93 96 7 genome genome NN cord-284627-qvz63m93 96 8 sequences sequence NNS cord-284627-qvz63m93 96 9 , , , cord-284627-qvz63m93 96 10 representative representative NN cord-284627-qvz63m93 96 11 entries entry NNS cord-284627-qvz63m93 96 12 from from IN cord-284627-qvz63m93 96 13 13 13 CD cord-284627-qvz63m93 96 14 countries country NNS cord-284627-qvz63m93 96 15 , , , cord-284627-qvz63m93 96 16 clearly clearly RB cord-284627-qvz63m93 96 17 showed show VBD cord-284627-qvz63m93 96 18 extremely extremely RB cord-284627-qvz63m93 96 19 conserved conserved JJ cord-284627-qvz63m93 96 20 sequence sequence NN cord-284627-qvz63m93 96 21 with with IN cord-284627-qvz63m93 96 22 only only RB cord-284627-qvz63m93 96 23 35 35 CD cord-284627-qvz63m93 96 24 mutations mutation NNS cord-284627-qvz63m93 96 25 ( ( -LRB- cord-284627-qvz63m93 96 26 Supplementary Supplementary NNP cord-284627-qvz63m93 96 27 Material Material NNP cord-284627-qvz63m93 96 28 1 1 CD cord-284627-qvz63m93 96 29 ) ) -RRB- cord-284627-qvz63m93 96 30 . . . cord-284627-qvz63m93 97 1 Only only JJ cord-284627-qvz63m93 97 2 viral viral JJ cord-284627-qvz63m93 97 3 genome genome NN cord-284627-qvz63m93 97 4 sequence sequence NN cord-284627-qvz63m93 97 5 identified identify VBN cord-284627-qvz63m93 97 6 from from IN cord-284627-qvz63m93 97 7 Taiwan Taiwan NNP cord-284627-qvz63m93 97 8 entry entry NN cord-284627-qvz63m93 97 9 does do VBZ cord-284627-qvz63m93 97 10 not not RB cord-284627-qvz63m93 97 11 show show VB cord-284627-qvz63m93 97 12 any any DT cord-284627-qvz63m93 97 13 mutation mutation NN cord-284627-qvz63m93 97 14 , , , cord-284627-qvz63m93 97 15 suggesting suggest VBG cord-284627-qvz63m93 97 16 this this DT cord-284627-qvz63m93 97 17 is be VBZ cord-284627-qvz63m93 97 18 the the DT cord-284627-qvz63m93 97 19 ancestral ancestral JJ cord-284627-qvz63m93 97 20 genome genome NN cord-284627-qvz63m93 97 21 sequence sequence NN cord-284627-qvz63m93 97 22 . . . cord-284627-qvz63m93 98 1 All all PDT cord-284627-qvz63m93 98 2 the the DT cord-284627-qvz63m93 98 3 mutations mutation NNS cord-284627-qvz63m93 98 4 of of IN cord-284627-qvz63m93 98 5 SARS SARS NNP cord-284627-qvz63m93 98 6 - - HYPH cord-284627-qvz63m93 98 7 CoV-2 CoV-2 NNP cord-284627-qvz63m93 98 8 identified identify VBN cord-284627-qvz63m93 98 9 were be VBD cord-284627-qvz63m93 98 10 reported report VBN cord-284627-qvz63m93 98 11 in in IN cord-284627-qvz63m93 98 12 Table Table NNP cord-284627-qvz63m93 98 13 1 1 CD cord-284627-qvz63m93 98 14 . . . cord-284627-qvz63m93 99 1 Among among IN cord-284627-qvz63m93 99 2 all all DT cord-284627-qvz63m93 99 3 mutations mutation NNS cord-284627-qvz63m93 99 4 , , , cord-284627-qvz63m93 99 5 a a DT cord-284627-qvz63m93 99 6 three three CD cord-284627-qvz63m93 99 7 nucleotide nucleotide JJ cord-284627-qvz63m93 99 8 deletion deletion NN cord-284627-qvz63m93 99 9 ( ( -LRB- cord-284627-qvz63m93 99 10 from from IN cord-284627-qvz63m93 99 11 21964 21964 CD cord-284627-qvz63m93 99 12 - - HYPH cord-284627-qvz63m93 99 13 21966 21966 CD cord-284627-qvz63m93 99 14 position position NN cord-284627-qvz63m93 99 15 ) ) -RRB- cord-284627-qvz63m93 99 16 was be VBD cord-284627-qvz63m93 99 17 observed observe VBN cord-284627-qvz63m93 99 18 only only RB cord-284627-qvz63m93 99 19 from from IN cord-284627-qvz63m93 99 20 MT012098 MT012098 NNP cord-284627-qvz63m93 99 21 strain strain NN cord-284627-qvz63m93 99 22 of of IN cord-284627-qvz63m93 99 23 India India NNP cord-284627-qvz63m93 99 24 . . . cord-284627-qvz63m93 100 1 The the DT cord-284627-qvz63m93 100 2 phylogenetic phylogenetic JJ cord-284627-qvz63m93 100 3 tree tree NN cord-284627-qvz63m93 100 4 analysis analysis NN cord-284627-qvz63m93 100 5 showed show VBD cord-284627-qvz63m93 100 6 the the DT cord-284627-qvz63m93 100 7 proximity proximity NN cord-284627-qvz63m93 100 8 of of IN cord-284627-qvz63m93 100 9 the the DT cord-284627-qvz63m93 100 10 viral viral JJ cord-284627-qvz63m93 100 11 strains strain NNS cord-284627-qvz63m93 100 12 of of IN cord-284627-qvz63m93 100 13 different different JJ cord-284627-qvz63m93 100 14 COVID-19 covid-19 JJ cord-284627-qvz63m93 100 15 affecting affect VBG cord-284627-qvz63m93 100 16 countries country NNS cord-284627-qvz63m93 100 17 . . . cord-284627-qvz63m93 101 1 Three three CD cord-284627-qvz63m93 101 2 distinct distinct JJ cord-284627-qvz63m93 101 3 clusters cluster NNS cord-284627-qvz63m93 101 4 have have VBP cord-284627-qvz63m93 101 5 been be VBN cord-284627-qvz63m93 101 6 found find VBN cord-284627-qvz63m93 101 7 ( ( -LRB- cord-284627-qvz63m93 101 8 _SP cord-284627-qvz63m93 101 9 All all PDT cord-284627-qvz63m93 101 10 the the DT cord-284627-qvz63m93 101 11 mutations mutation NNS cord-284627-qvz63m93 101 12 are be VBP cord-284627-qvz63m93 101 13 screened screen VBN cord-284627-qvz63m93 101 14 depending depend VBG cord-284627-qvz63m93 101 15 upon upon IN cord-284627-qvz63m93 101 16 their -PRON- PRP$ cord-284627-qvz63m93 101 17 rarity rarity NN cord-284627-qvz63m93 101 18 to to TO cord-284627-qvz63m93 101 19 occur occur VB cord-284627-qvz63m93 101 20 in in IN cord-284627-qvz63m93 101 21 this this DT cord-284627-qvz63m93 101 22 viral viral JJ cord-284627-qvz63m93 101 23 genome genome NN cord-284627-qvz63m93 101 24 and and CC cord-284627-qvz63m93 101 25 A a NN cord-284627-qvz63m93 101 26 > > XX cord-284627-qvz63m93 101 27 T t NN cord-284627-qvz63m93 101 28 , , , cord-284627-qvz63m93 101 29 G g NN cord-284627-qvz63m93 101 30 > > XX cord-284627-qvz63m93 102 1 A a NN cord-284627-qvz63m93 102 2 and and CC cord-284627-qvz63m93 102 3 T t NN cord-284627-qvz63m93 102 4 > > XX cord-284627-qvz63m93 103 1 A a DT cord-284627-qvz63m93 103 2 are be VBP cord-284627-qvz63m93 103 3 found find VBN cord-284627-qvz63m93 103 4 to to TO cord-284627-qvz63m93 103 5 be be VB cord-284627-qvz63m93 103 6 very very RB cord-284627-qvz63m93 103 7 rare rare JJ cord-284627-qvz63m93 103 8 alterations alteration NNS cord-284627-qvz63m93 103 9 with with IN cord-284627-qvz63m93 103 10 LOD lod NN cord-284627-qvz63m93 103 11 score score NN cord-284627-qvz63m93 103 12 value value NN cord-284627-qvz63m93 103 13 less less JJR cord-284627-qvz63m93 103 14 than than IN cord-284627-qvz63m93 103 15 -0·5 -0·5 NN cord-284627-qvz63m93 103 16 where where WRB cord-284627-qvz63m93 103 17 as as IN cord-284627-qvz63m93 103 18 C C NNP cord-284627-qvz63m93 104 1 > > XX cord-284627-qvz63m93 105 1 T T NNP cord-284627-qvz63m93 105 2 is be VBZ cord-284627-qvz63m93 105 3 the the DT cord-284627-qvz63m93 105 4 most most RBS cord-284627-qvz63m93 105 5 common common JJ cord-284627-qvz63m93 105 6 alteration alteration NN cord-284627-qvz63m93 105 7 with with IN cord-284627-qvz63m93 105 8 LOD LOD NNP cord-284627-qvz63m93 105 9 score score NN cord-284627-qvz63m93 105 10 1·81 1·81 CD cord-284627-qvz63m93 105 11 . . . cord-284627-qvz63m93 106 1 Variation variation NN cord-284627-qvz63m93 106 2 analysis analysis NN cord-284627-qvz63m93 106 3 at at IN cord-284627-qvz63m93 106 4 Protein Protein NNP cord-284627-qvz63m93 106 5 level level NN cord-284627-qvz63m93 107 1 Different different JJ cord-284627-qvz63m93 107 2 protein protein NN cord-284627-qvz63m93 107 3 sequences sequence NNS cord-284627-qvz63m93 107 4 are be VBP cord-284627-qvz63m93 107 5 obtained obtain VBN cord-284627-qvz63m93 107 6 using use VBG cord-284627-qvz63m93 107 7 ORF ORF NNP cord-284627-qvz63m93 107 8 finder finder NN cord-284627-qvz63m93 107 9 and and CC cord-284627-qvz63m93 107 10 those those DT cord-284627-qvz63m93 107 11 sequences sequence NNS cord-284627-qvz63m93 107 12 were be VBD cord-284627-qvz63m93 107 13 matched match VBN cord-284627-qvz63m93 107 14 with with IN cord-284627-qvz63m93 107 15 existing exist VBG cord-284627-qvz63m93 107 16 Orf1ab Orf1ab NNP cord-284627-qvz63m93 107 17 polyprotein polyprotein NN cord-284627-qvz63m93 107 18 , , , cord-284627-qvz63m93 107 19 spike spike NN cord-284627-qvz63m93 107 20 like like IN cord-284627-qvz63m93 107 21 surface surface NN cord-284627-qvz63m93 107 22 glycoprotein glycoprotein NN cord-284627-qvz63m93 107 23 , , , cord-284627-qvz63m93 107 24 nucleocapsid nucleocapsid NN cord-284627-qvz63m93 107 25 phosphoprotein phosphoprotein NNP cord-284627-qvz63m93 107 26 etc etc FW cord-284627-qvz63m93 107 27 . . . cord-284627-qvz63m93 108 1 to to TO cord-284627-qvz63m93 108 2 ensure ensure VB cord-284627-qvz63m93 108 3 prediction prediction NN cord-284627-qvz63m93 108 4 of of IN cord-284627-qvz63m93 108 5 in in IN cord-284627-qvz63m93 108 6 silico silico NNP cord-284627-qvz63m93 108 7 ORF ORF NNP cord-284627-qvz63m93 108 8 with with IN cord-284627-qvz63m93 108 9 corresponding correspond VBG cord-284627-qvz63m93 108 10 SARS SARS NNP cord-284627-qvz63m93 108 11 - - HYPH cord-284627-qvz63m93 108 12 CoV-2 CoV-2 NNP cord-284627-qvz63m93 108 13 protein protein NN cord-284627-qvz63m93 108 14 . . . cord-284627-qvz63m93 109 1 Next next RB cord-284627-qvz63m93 109 2 , , , cord-284627-qvz63m93 109 3 observed observed JJ cord-284627-qvz63m93 109 4 mutations mutation NNS cord-284627-qvz63m93 109 5 were be VBD cord-284627-qvz63m93 109 6 confirmed confirm VBN cord-284627-qvz63m93 109 7 at at IN cord-284627-qvz63m93 109 8 amino amino NN cord-284627-qvz63m93 109 9 acid acid NN cord-284627-qvz63m93 109 10 level level NN cord-284627-qvz63m93 109 11 and and CC cord-284627-qvz63m93 109 12 identified identify VBD cord-284627-qvz63m93 109 13 a a DT cord-284627-qvz63m93 109 14 total total NN cord-284627-qvz63m93 109 15 of of IN cord-284627-qvz63m93 109 16 20 20 CD cord-284627-qvz63m93 109 17 Nonsynonymous Nonsynonymous NNP cord-284627-qvz63m93 109 18 ( ( -LRB- cord-284627-qvz63m93 109 19 NS NS NNP cord-284627-qvz63m93 109 20 ) ) -RRB- cord-284627-qvz63m93 109 21 and and CC cord-284627-qvz63m93 109 22 14 14 CD cord-284627-qvz63m93 109 23 Synonymous Synonymous NNP cord-284627-qvz63m93 109 24 ( ( -LRB- cord-284627-qvz63m93 109 25 S S NNP cord-284627-qvz63m93 109 26 ) ) -RRB- cord-284627-qvz63m93 109 27 mutations mutation NNS cord-284627-qvz63m93 109 28 ( ( -LRB- cord-284627-qvz63m93 109 29 Table table NN cord-284627-qvz63m93 109 30 2 2 CD cord-284627-qvz63m93 109 31 ) ) -RRB- cord-284627-qvz63m93 109 32 . . . cord-284627-qvz63m93 110 1 The the DT cord-284627-qvz63m93 110 2 analysis analysis NN cord-284627-qvz63m93 110 3 with with IN cord-284627-qvz63m93 110 4 different different JJ cord-284627-qvz63m93 110 5 SNP SNP NNP cord-284627-qvz63m93 110 6 annotation annotation NN cord-284627-qvz63m93 110 7 tools tool NNS cord-284627-qvz63m93 110 8 like like IN cord-284627-qvz63m93 110 9 SIFT SIFT NNP cord-284627-qvz63m93 110 10 , , , cord-284627-qvz63m93 110 11 16 16 CD cord-284627-qvz63m93 110 12 SNAP snap VB cord-284627-qvz63m93 110 13 , , , cord-284627-qvz63m93 110 14 17 17 CD cord-284627-qvz63m93 110 15 Polyphen2 Polyphen2 NNP cord-284627-qvz63m93 110 16 , , , cord-284627-qvz63m93 110 17 18 18 CD cord-284627-qvz63m93 110 18 MetaSNP MetaSNP NNP cord-284627-qvz63m93 110 19 19 19 CD cord-284627-qvz63m93 110 20 showed show VBD cord-284627-qvz63m93 110 21 the the DT cord-284627-qvz63m93 110 22 functional functional JJ cord-284627-qvz63m93 110 23 impact impact NN cord-284627-qvz63m93 110 24 of of IN cord-284627-qvz63m93 110 25 NS NS NNP cord-284627-qvz63m93 110 26 mutations mutation NNS cord-284627-qvz63m93 110 27 at at IN cord-284627-qvz63m93 110 28 different different JJ cord-284627-qvz63m93 110 29 level level NN cord-284627-qvz63m93 110 30 , , , cord-284627-qvz63m93 110 31 predicting predict VBG cord-284627-qvz63m93 110 32 either either CC cord-284627-qvz63m93 110 33 tolerance tolerance NN cord-284627-qvz63m93 110 34 of of IN cord-284627-qvz63m93 110 35 the the DT cord-284627-qvz63m93 110 36 mutation mutation NN cord-284627-qvz63m93 110 37 , , , cord-284627-qvz63m93 110 38 or or CC cord-284627-qvz63m93 110 39 disease disease NN cord-284627-qvz63m93 110 40 causing cause VBG cord-284627-qvz63m93 110 41 ability ability NN cord-284627-qvz63m93 110 42 , , , cord-284627-qvz63m93 110 43 or or CC cord-284627-qvz63m93 110 44 executing execute VBG cord-284627-qvz63m93 110 45 risk risk NN cord-284627-qvz63m93 110 46 or or CC cord-284627-qvz63m93 110 47 damage damage NN cord-284627-qvz63m93 110 48 , , , cord-284627-qvz63m93 110 49 which which WDT cord-284627-qvz63m93 110 50 altogether altogether RB cord-284627-qvz63m93 110 51 can can MD cord-284627-qvz63m93 110 52 infer infer VB cord-284627-qvz63m93 110 53 the the DT cord-284627-qvz63m93 110 54 fatality fatality NN cord-284627-qvz63m93 110 55 rate rate NN cord-284627-qvz63m93 110 56 . . . cord-284627-qvz63m93 111 1 The the DT cord-284627-qvz63m93 111 2 fatality fatality NN cord-284627-qvz63m93 111 3 rate rate NN cord-284627-qvz63m93 111 4 of of IN cord-284627-qvz63m93 111 5 Italy Italy NNP cord-284627-qvz63m93 111 6 ( ( -LRB- cord-284627-qvz63m93 111 7 14·82 14·82 CD cord-284627-qvz63m93 111 8 % % NN cord-284627-qvz63m93 111 9 ) ) -RRB- cord-284627-qvz63m93 111 10 , , , cord-284627-qvz63m93 111 11 Spain Spain NNP cord-284627-qvz63m93 111 12 ( ( -LRB- cord-284627-qvz63m93 111 13 13·77 13·77 CD cord-284627-qvz63m93 111 14 % % NN cord-284627-qvz63m93 111 15 ) ) -RRB- cord-284627-qvz63m93 111 16 and and CC cord-284627-qvz63m93 111 17 Sweden Sweden NNP cord-284627-qvz63m93 111 18 ( ( -LRB- cord-284627-qvz63m93 111 19 9·20 9·20 CD cord-284627-qvz63m93 111 20 % % NN cord-284627-qvz63m93 111 21 ) ) -RRB- cord-284627-qvz63m93 111 22 were be VBD cord-284627-qvz63m93 111 23 significantly significantly RB cord-284627-qvz63m93 111 24 higher high JJR cord-284627-qvz63m93 111 25 , , , cord-284627-qvz63m93 111 26 where where WRB cord-284627-qvz63m93 111 27 it -PRON- PRP cord-284627-qvz63m93 111 28 was be VBD cord-284627-qvz63m93 111 29 less less JJR cord-284627-qvz63m93 111 30 than than IN cord-284627-qvz63m93 111 31 4 4 CD cord-284627-qvz63m93 111 32 % % NN cord-284627-qvz63m93 111 33 in in IN cord-284627-qvz63m93 111 34 countries country NNS cord-284627-qvz63m93 111 35 like like IN cord-284627-qvz63m93 111 36 Nepal Nepal NNP cord-284627-qvz63m93 111 37 ( ( -LRB- cord-284627-qvz63m93 111 38 Zero zero CD cord-284627-qvz63m93 111 39 fatality fatality NN cord-284627-qvz63m93 111 40 ) ) -RRB- cord-284627-qvz63m93 111 41 , , , cord-284627-qvz63m93 111 42 Finland Finland NNP cord-284627-qvz63m93 111 43 ( ( -LRB- cord-284627-qvz63m93 111 44 2·63 2·63 CD cord-284627-qvz63m93 111 45 % % NN cord-284627-qvz63m93 111 46 ) ) -RRB- cord-284627-qvz63m93 111 47 , , , cord-284627-qvz63m93 111 48 Vietnam Vietnam NNP cord-284627-qvz63m93 111 49 ( ( -LRB- cord-284627-qvz63m93 111 50 2·01 2·01 CD cord-284627-qvz63m93 111 51 % % NN cord-284627-qvz63m93 111 52 ) ) -RRB- cord-284627-qvz63m93 111 53 , , , cord-284627-qvz63m93 111 54 USA USA NNP cord-284627-qvz63m93 111 55 ( ( -LRB- cord-284627-qvz63m93 111 56 3·80 3·80 CD cord-284627-qvz63m93 111 57 ) ) -RRB- cord-284627-qvz63m93 111 58 , , , cord-284627-qvz63m93 111 59 Australia Australia NNP cord-284627-qvz63m93 111 60 ( ( -LRB- cord-284627-qvz63m93 111 61 0·91 0·91 CD cord-284627-qvz63m93 111 62 % % NN cord-284627-qvz63m93 111 63 ) ) -RRB- cord-284627-qvz63m93 111 64 and and CC cord-284627-qvz63m93 111 65 India India NNP cord-284627-qvz63m93 111 66 ( ( -LRB- cord-284627-qvz63m93 111 67 2·06 2·06 CD cord-284627-qvz63m93 111 68 ) ) -RRB- cord-284627-qvz63m93 111 69 . . . cord-284627-qvz63m93 112 1 In in IN cord-284627-qvz63m93 112 2 case case NN cord-284627-qvz63m93 112 3 of of IN cord-284627-qvz63m93 112 4 Japan Japan NNP cord-284627-qvz63m93 112 5 , , , cord-284627-qvz63m93 112 6 Brazil Brazil NNP cord-284627-qvz63m93 112 7 and and CC cord-284627-qvz63m93 112 8 China China NNP cord-284627-qvz63m93 112 9 , , , cord-284627-qvz63m93 112 10 fatality fatality NN cord-284627-qvz63m93 112 11 rate rate NN cord-284627-qvz63m93 112 12 was be VBD cord-284627-qvz63m93 112 13 moderate moderate JJ cord-284627-qvz63m93 112 14 i.e i.e XX cord-284627-qvz63m93 112 15 approximately approximately RB cord-284627-qvz63m93 112 16 4 4 CD cord-284627-qvz63m93 112 17 - - SYM cord-284627-qvz63m93 112 18 8 8 CD cord-284627-qvz63m93 112 19 % % NN cord-284627-qvz63m93 112 20 ( ( -LRB- cord-284627-qvz63m93 112 21 figure figure NN cord-284627-qvz63m93 112 22 3 3 CD cord-284627-qvz63m93 112 23 ) ) -RRB- cord-284627-qvz63m93 112 24 . . . cord-284627-qvz63m93 113 1 The the DT cord-284627-qvz63m93 113 2 number number NN cord-284627-qvz63m93 113 3 of of IN cord-284627-qvz63m93 113 4 mutations mutation NNS cord-284627-qvz63m93 113 5 and and CC cord-284627-qvz63m93 113 6 presence presence NN cord-284627-qvz63m93 113 7 of of IN cord-284627-qvz63m93 113 8 either either DT cord-284627-qvz63m93 113 9 of of IN cord-284627-qvz63m93 113 10 the the DT cord-284627-qvz63m93 113 11 very very RB cord-284627-qvz63m93 113 12 rare rare JJ cord-284627-qvz63m93 113 13 mutations mutation NNS cord-284627-qvz63m93 113 14 or or CC cord-284627-qvz63m93 113 15 functionally functionally RB cord-284627-qvz63m93 113 16 important important JJ cord-284627-qvz63m93 113 17 NS NS NNP cord-284627-qvz63m93 113 18 mutations mutation NNS cord-284627-qvz63m93 113 19 or or CC cord-284627-qvz63m93 113 20 both both DT cord-284627-qvz63m93 113 21 are be VBP cord-284627-qvz63m93 113 22 found find VBN cord-284627-qvz63m93 113 23 to to TO cord-284627-qvz63m93 113 24 be be VB cord-284627-qvz63m93 113 25 strongly strongly RB cord-284627-qvz63m93 113 26 linked link VBN cord-284627-qvz63m93 113 27 with with IN cord-284627-qvz63m93 113 28 the the DT cord-284627-qvz63m93 113 29 fatality fatality NN cord-284627-qvz63m93 113 30 rate rate NN cord-284627-qvz63m93 113 31 ( ( -LRB- cord-284627-qvz63m93 113 32 Table table NN cord-284627-qvz63m93 113 33 3A 3a CD cord-284627-qvz63m93 113 34 - - HYPH cord-284627-qvz63m93 113 35 Table table NN cord-284627-qvz63m93 113 36 3C 3c NN cord-284627-qvz63m93 113 37 ) ) -RRB- cord-284627-qvz63m93 113 38 . . . cord-284627-qvz63m93 114 1 It -PRON- PRP cord-284627-qvz63m93 114 2 is be VBZ cord-284627-qvz63m93 114 3 extremely extremely RB cord-284627-qvz63m93 114 4 important important JJ cord-284627-qvz63m93 114 5 to to TO cord-284627-qvz63m93 114 6 understand understand VB cord-284627-qvz63m93 114 7 how how WRB cord-284627-qvz63m93 114 8 the the DT cord-284627-qvz63m93 114 9 ancestral ancestral JJ cord-284627-qvz63m93 114 10 strain strain NN cord-284627-qvz63m93 114 11 ( ( -LRB- cord-284627-qvz63m93 114 12 S s NN cord-284627-qvz63m93 114 13 ) ) -RRB- cord-284627-qvz63m93 114 14 leads lead VBZ cord-284627-qvz63m93 114 15 to to IN cord-284627-qvz63m93 114 16 lethal lethal JJ cord-284627-qvz63m93 114 17 strain strain NN cord-284627-qvz63m93 114 18 ( ( -LRB- cord-284627-qvz63m93 114 19 L l NN cord-284627-qvz63m93 114 20 ) ) -RRB- cord-284627-qvz63m93 114 21 and and CC cord-284627-qvz63m93 114 22 other other JJ cord-284627-qvz63m93 114 23 clusters cluster NNS cord-284627-qvz63m93 114 24 observed observe VBD cord-284627-qvz63m93 114 25 according accord VBG cord-284627-qvz63m93 114 26 to to IN cord-284627-qvz63m93 114 27 phylogeny phylogeny NN cord-284627-qvz63m93 114 28 . . . cord-284627-qvz63m93 115 1 Our -PRON- PRP$ cord-284627-qvz63m93 115 2 analysis analysis NN cord-284627-qvz63m93 115 3 showed show VBD cord-284627-qvz63m93 115 4 Ancestral ancestral JJ cord-284627-qvz63m93 115 5 strain strain NN cord-284627-qvz63m93 115 6 ( ( -LRB- cord-284627-qvz63m93 115 7 S s NN cord-284627-qvz63m93 115 8 ) ) -RRB- cord-284627-qvz63m93 115 9 give give VBP cord-284627-qvz63m93 115 10 rise rise NN cord-284627-qvz63m93 115 11 to to IN cord-284627-qvz63m93 115 12 an an DT cord-284627-qvz63m93 115 13 Intermediate Intermediate NNP cord-284627-qvz63m93 115 14 strain strain NN cord-284627-qvz63m93 115 15 ( ( -LRB- cord-284627-qvz63m93 115 16 I i NN cord-284627-qvz63m93 115 17 ) ) -RRB- cord-284627-qvz63m93 115 18 with with IN cord-284627-qvz63m93 115 19 single single JJ cord-284627-qvz63m93 115 20 very very RB cord-284627-qvz63m93 115 21 common common JJ cord-284627-qvz63m93 115 22 mutation mutation NN cord-284627-qvz63m93 115 23 , , , cord-284627-qvz63m93 115 24 a a DT cord-284627-qvz63m93 115 25 transition transition NN cord-284627-qvz63m93 115 26 from from IN cord-284627-qvz63m93 115 27 C C NNP cord-284627-qvz63m93 115 28 to to IN cord-284627-qvz63m93 115 29 T. t. NN cord-284627-qvz63m93 116 1 From from IN cord-284627-qvz63m93 116 2 I -PRON- PRP cord-284627-qvz63m93 116 3 , , , cord-284627-qvz63m93 116 4 three three CD cord-284627-qvz63m93 116 5 different different JJ cord-284627-qvz63m93 116 6 strains strain NNS cord-284627-qvz63m93 116 7 originate originate VBP cord-284627-qvz63m93 116 8 , , , cord-284627-qvz63m93 116 9 i.e i.e FW cord-284627-qvz63m93 116 10 ( ( -LRB- cord-284627-qvz63m93 116 11 a a DT cord-284627-qvz63m93 116 12 ) ) -RRB- cord-284627-qvz63m93 116 13 Lethal lethal JJ cord-284627-qvz63m93 116 14 strain strain NN cord-284627-qvz63m93 116 15 ( ( -LRB- cord-284627-qvz63m93 116 16 L L NNP cord-284627-qvz63m93 116 17 ) ) -RRB- cord-284627-qvz63m93 116 18 , , , cord-284627-qvz63m93 116 19 with with IN cord-284627-qvz63m93 116 20 additional additional JJ cord-284627-qvz63m93 116 21 mutations mutation NNS cord-284627-qvz63m93 116 22 over over IN cord-284627-qvz63m93 116 23 I -PRON- PRP cord-284627-qvz63m93 116 24 , , , cord-284627-qvz63m93 116 25 ( ( -LRB- cord-284627-qvz63m93 116 26 b b LS cord-284627-qvz63m93 116 27 ) ) -RRB- cord-284627-qvz63m93 116 28 Extremely extremely RB cord-284627-qvz63m93 116 29 lethal lethal JJ cord-284627-qvz63m93 116 30 strain strain NN cord-284627-qvz63m93 116 31 ( ( -LRB- cord-284627-qvz63m93 116 32 E e NN cord-284627-qvz63m93 116 33 ) ) -RRB- cord-284627-qvz63m93 116 34 that that WDT cord-284627-qvz63m93 116 35 contains contain VBZ cord-284627-qvz63m93 116 36 very very RB cord-284627-qvz63m93 116 37 rare rare JJ cord-284627-qvz63m93 116 38 mutations mutation NNS cord-284627-qvz63m93 116 39 and and CC cord-284627-qvz63m93 116 40 a a DT cord-284627-qvz63m93 116 41 ( ( -LRB- cord-284627-qvz63m93 116 42 c c NN cord-284627-qvz63m93 116 43 ) ) -RRB- cord-284627-qvz63m93 116 44 Non Non NNP cord-284627-qvz63m93 116 45 Lethal lethal JJ cord-284627-qvz63m93 116 46 strain strain NN cord-284627-qvz63m93 116 47 ( ( -LRB- cord-284627-qvz63m93 116 48 N n NN cord-284627-qvz63m93 116 49 ) ) -RRB- cord-284627-qvz63m93 116 50 that that WDT cord-284627-qvz63m93 116 51 contains contain VBZ cord-284627-qvz63m93 116 52 favourable favourable JJ cord-284627-qvz63m93 116 53 mutations mutation NNS cord-284627-qvz63m93 116 54 at at IN cord-284627-qvz63m93 116 55 surface surface NN cord-284627-qvz63m93 116 56 glycoprotein glycoprotein NN cord-284627-qvz63m93 116 57 , , , cord-284627-qvz63m93 116 58 which which WDT cord-284627-qvz63m93 116 59 possibly possibly RB cord-284627-qvz63m93 116 60 inhibit inhibit VBP cord-284627-qvz63m93 116 61 the the DT cord-284627-qvz63m93 116 62 interaction interaction NN cord-284627-qvz63m93 116 63 of of IN cord-284627-qvz63m93 116 64 ACE2 ACE2 NNP cord-284627-qvz63m93 116 65 and and CC cord-284627-qvz63m93 116 66 favouring favour VBG cord-284627-qvz63m93 116 67 non non JJ cord-284627-qvz63m93 116 68 - - JJ cord-284627-qvz63m93 116 69 lethal lethal JJ cord-284627-qvz63m93 116 70 outcome outcome NN cord-284627-qvz63m93 116 71 ( ( -LRB- cord-284627-qvz63m93 116 72 figure figure NN cord-284627-qvz63m93 116 73 4 4 CD cord-284627-qvz63m93 116 74 ) ) -RRB- cord-284627-qvz63m93 116 75 . . . cord-284627-qvz63m93 117 1 The the DT cord-284627-qvz63m93 117 2 current current JJ cord-284627-qvz63m93 117 3 global global JJ cord-284627-qvz63m93 117 4 pandemic pandemic NN cord-284627-qvz63m93 117 5 of of IN cord-284627-qvz63m93 117 6 the the DT cord-284627-qvz63m93 117 7 novel novel JJ cord-284627-qvz63m93 117 8 coronavirus coronavirus NN cord-284627-qvz63m93 117 9 Covid-19 covid-19 VB cord-284627-qvz63m93 117 10 created create VBN cord-284627-qvz63m93 117 11 two two CD cord-284627-qvz63m93 117 12 epicenters epicenter NNS cord-284627-qvz63m93 117 13 first first RB cord-284627-qvz63m93 117 14 at at IN cord-284627-qvz63m93 117 15 Hubei Hubei NNP cord-284627-qvz63m93 117 16 Province Province NNP cord-284627-qvz63m93 117 17 in in IN cord-284627-qvz63m93 117 18 People People NNPS cord-284627-qvz63m93 117 19 's 's POS cord-284627-qvz63m93 117 20 Republic Republic NNP cord-284627-qvz63m93 117 21 of of IN cord-284627-qvz63m93 117 22 China China NNP cord-284627-qvz63m93 117 23 and and CC cord-284627-qvz63m93 117 24 presently presently RB cord-284627-qvz63m93 117 25 in in IN cord-284627-qvz63m93 117 26 Europe Europe NNP cord-284627-qvz63m93 117 27 . . . cord-284627-qvz63m93 118 1 SARS SARS NNP cord-284627-qvz63m93 118 2 - - HYPH cord-284627-qvz63m93 118 3 CoV-2 CoV-2 NNP cord-284627-qvz63m93 118 4 , , , cord-284627-qvz63m93 118 5 like like IN cord-284627-qvz63m93 118 6 its -PRON- PRP$ cord-284627-qvz63m93 118 7 close close JJ cord-284627-qvz63m93 118 8 relatives relative NNS cord-284627-qvz63m93 118 9 SARS SARS NNP cord-284627-qvz63m93 118 10 - - HYPH cord-284627-qvz63m93 118 11 CoV CoV NNP cord-284627-qvz63m93 118 12 and and CC cord-284627-qvz63m93 118 13 MERS MERS NNP cord-284627-qvz63m93 118 14 - - HYPH cord-284627-qvz63m93 118 15 CoV CoV NNP cord-284627-qvz63m93 118 16 , , , cord-284627-qvz63m93 118 17 is be VBZ cord-284627-qvz63m93 118 18 also also RB cord-284627-qvz63m93 118 19 pathogenic pathogenic JJ cord-284627-qvz63m93 118 20 but but CC cord-284627-qvz63m93 118 21 with with IN cord-284627-qvz63m93 118 22 a a DT cord-284627-qvz63m93 118 23 higher high JJR cord-284627-qvz63m93 118 24 infectivity infectivity NN cord-284627-qvz63m93 118 25 rate rate NN cord-284627-qvz63m93 118 26 . . . cord-284627-qvz63m93 119 1 The the DT cord-284627-qvz63m93 119 2 increasing increase VBG cord-284627-qvz63m93 119 3 number number NN cord-284627-qvz63m93 119 4 of of IN cord-284627-qvz63m93 119 5 cases case NNS cord-284627-qvz63m93 119 6 and and CC cord-284627-qvz63m93 119 7 wide wide JJ cord-284627-qvz63m93 119 8 spread spread NN cord-284627-qvz63m93 119 9 disease disease NN cord-284627-qvz63m93 119 10 raise raise VBP cord-284627-qvz63m93 119 11 grave grave JJ cord-284627-qvz63m93 119 12 concerns concern NNS cord-284627-qvz63m93 119 13 about about IN cord-284627-qvz63m93 119 14 the the DT cord-284627-qvz63m93 119 15 future future JJ cord-284627-qvz63m93 119 16 trajectory trajectory NN cord-284627-qvz63m93 119 17 of of IN cord-284627-qvz63m93 119 18 the the DT cord-284627-qvz63m93 119 19 pandemic pandemic NN cord-284627-qvz63m93 119 20 and and CC cord-284627-qvz63m93 119 21 thus thus RB cord-284627-qvz63m93 119 22 , , , cord-284627-qvz63m93 119 23 a a DT cord-284627-qvz63m93 119 24 better well JJR cord-284627-qvz63m93 119 25 understanding understanding NN cord-284627-qvz63m93 119 26 regarding regard VBG cord-284627-qvz63m93 119 27 the the DT cord-284627-qvz63m93 119 28 molecular molecular JJ cord-284627-qvz63m93 119 29 divergence divergence NN cord-284627-qvz63m93 119 30 of of IN cord-284627-qvz63m93 119 31 viral viral JJ cord-284627-qvz63m93 119 32 strains strain NNS cord-284627-qvz63m93 119 33 and and CC cord-284627-qvz63m93 119 34 pathogenesis pathogenesis NN cord-284627-qvz63m93 119 35 , , , cord-284627-qvz63m93 119 36 is be VBZ cord-284627-qvz63m93 119 37 utmost utmost RB cord-284627-qvz63m93 119 38 important important JJ cord-284627-qvz63m93 119 39 . . . cord-284627-qvz63m93 120 1 The the DT cord-284627-qvz63m93 120 2 present present JJ cord-284627-qvz63m93 120 3 study study NN cord-284627-qvz63m93 120 4 attempted attempt VBD cord-284627-qvz63m93 120 5 to to TO cord-284627-qvz63m93 120 6 categorize categorize VB cord-284627-qvz63m93 120 7 COVID COVID NNP cord-284627-qvz63m93 120 8 affected affected JJ cord-284627-qvz63m93 120 9 countries country NNS cord-284627-qvz63m93 120 10 based base VBN cord-284627-qvz63m93 120 11 on on IN cord-284627-qvz63m93 120 12 molecular molecular JJ cord-284627-qvz63m93 120 13 pathogenesis pathogenesis NN cord-284627-qvz63m93 120 14 . . . cord-284627-qvz63m93 121 1 Three three CD cord-284627-qvz63m93 121 2 important important JJ cord-284627-qvz63m93 121 3 factors factor NNS cord-284627-qvz63m93 121 4 were be VBD cord-284627-qvz63m93 121 5 considered consider VBN cord-284627-qvz63m93 121 6 , , , cord-284627-qvz63m93 122 1 i.e i.e NNP cord-284627-qvz63m93 122 2 , , , cord-284627-qvz63m93 122 3 number number NN cord-284627-qvz63m93 122 4 of of IN cord-284627-qvz63m93 122 5 mutations mutation NNS cord-284627-qvz63m93 122 6 during during IN cord-284627-qvz63m93 122 7 evolution evolution NN cord-284627-qvz63m93 122 8 , , , cord-284627-qvz63m93 122 9 rarity rarity NN cord-284627-qvz63m93 122 10 of of IN cord-284627-qvz63m93 122 11 the the DT cord-284627-qvz63m93 122 12 allelic allelic JJ cord-284627-qvz63m93 122 13 substitution substitution NN cord-284627-qvz63m93 122 14 and and CC cord-284627-qvz63m93 122 15 functional functional JJ cord-284627-qvz63m93 122 16 alteration alteration NN cord-284627-qvz63m93 122 17 of of IN cord-284627-qvz63m93 122 18 the the DT cord-284627-qvz63m93 122 19 non non JJ cord-284627-qvz63m93 122 20 - - JJ cord-284627-qvz63m93 122 21 synonymous synonymous JJ cord-284627-qvz63m93 122 22 mutations mutation NNS cord-284627-qvz63m93 122 23 . . . cord-284627-qvz63m93 123 1 We -PRON- PRP cord-284627-qvz63m93 123 2 screened screen VBD cord-284627-qvz63m93 123 3 and and CC cord-284627-qvz63m93 123 4 compared compare VBN cord-284627-qvz63m93 123 5 extent extent NN cord-284627-qvz63m93 123 6 of of IN cord-284627-qvz63m93 123 7 mutations mutation NNS cord-284627-qvz63m93 123 8 observed observe VBN cord-284627-qvz63m93 123 9 in in IN cord-284627-qvz63m93 123 10 genome genome NN cord-284627-qvz63m93 123 11 sequence sequence NN cord-284627-qvz63m93 123 12 of of IN cord-284627-qvz63m93 123 13 SARS SARS NNP cord-284627-qvz63m93 123 14 - - HYPH cord-284627-qvz63m93 123 15 CoV-2 CoV-2 NNP cord-284627-qvz63m93 123 16 . . . cord-284627-qvz63m93 124 1 All all DT cord-284627-qvz63m93 124 2 reported report VBN cord-284627-qvz63m93 124 3 genome genome NN cord-284627-qvz63m93 124 4 sequences sequence NNS cord-284627-qvz63m93 124 5 of of IN cord-284627-qvz63m93 124 6 13 13 CD cord-284627-qvz63m93 124 7 affected affected JJ cord-284627-qvz63m93 124 8 countries country NNS cord-284627-qvz63m93 124 9 have have VBP cord-284627-qvz63m93 124 10 been be VBN cord-284627-qvz63m93 124 11 analyzed analyze VBN cord-284627-qvz63m93 124 12 . . . cord-284627-qvz63m93 125 1 So so RB cord-284627-qvz63m93 125 2 far far RB cord-284627-qvz63m93 125 3 , , , cord-284627-qvz63m93 125 4 studies study NNS cord-284627-qvz63m93 125 5 indicated indicate VBD cord-284627-qvz63m93 125 6 that that IN cord-284627-qvz63m93 125 7 there there EX cord-284627-qvz63m93 125 8 are be VBP cord-284627-qvz63m93 125 9 only only RB cord-284627-qvz63m93 125 10 two two CD cord-284627-qvz63m93 125 11 strains strain NNS cord-284627-qvz63m93 125 12 , , , cord-284627-qvz63m93 125 13 S S NNP cord-284627-qvz63m93 125 14 , , , cord-284627-qvz63m93 125 15 possibly possibly RB cord-284627-qvz63m93 125 16 the the DT cord-284627-qvz63m93 125 17 ancestral ancestral JJ cord-284627-qvz63m93 125 18 one one NN cord-284627-qvz63m93 125 19 and and CC cord-284627-qvz63m93 125 20 L L NNP cord-284627-qvz63m93 125 21 , , , cord-284627-qvz63m93 125 22 might may MD cord-284627-qvz63m93 125 23 be be VB cord-284627-qvz63m93 125 24 the the DT cord-284627-qvz63m93 125 25 lethal lethal JJ cord-284627-qvz63m93 125 26 and and CC cord-284627-qvz63m93 125 27 more more RBR cord-284627-qvz63m93 125 28 aggressive aggressive JJ cord-284627-qvz63m93 125 29 one one CD cord-284627-qvz63m93 125 30 . . . cord-284627-qvz63m93 126 1 The the DT cord-284627-qvz63m93 126 2 distinct distinct JJ cord-284627-qvz63m93 126 3 clusters cluster NNS cord-284627-qvz63m93 126 4 that that WDT cord-284627-qvz63m93 126 5 we -PRON- PRP cord-284627-qvz63m93 126 6 observed observe VBD cord-284627-qvz63m93 126 7 from from IN cord-284627-qvz63m93 126 8 our -PRON- PRP$ cord-284627-qvz63m93 126 9 phylogenetic phylogenetic JJ cord-284627-qvz63m93 126 10 tree tree NN cord-284627-qvz63m93 126 11 construction construction NN cord-284627-qvz63m93 126 12 raise raise VBP cord-284627-qvz63m93 126 13 the the DT cord-284627-qvz63m93 126 14 assumption assumption NN cord-284627-qvz63m93 126 15 of of IN cord-284627-qvz63m93 126 16 existence existence NN cord-284627-qvz63m93 126 17 of of IN cord-284627-qvz63m93 126 18 many many JJ cord-284627-qvz63m93 126 19 more more JJR cord-284627-qvz63m93 126 20 unknown unknown JJ cord-284627-qvz63m93 126 21 strains strain NNS cord-284627-qvz63m93 126 22 ( ( -LRB- cord-284627-qvz63m93 126 23 figure figure NN cord-284627-qvz63m93 126 24 5 5 CD cord-284627-qvz63m93 126 25 ) ) -RRB- cord-284627-qvz63m93 126 26 . . . cord-284627-qvz63m93 127 1 One one CD cord-284627-qvz63m93 127 2 interesting interesting JJ cord-284627-qvz63m93 127 3 report report NN cord-284627-qvz63m93 127 4 substantiating substantiate VBG cord-284627-qvz63m93 127 5 our -PRON- PRP$ cord-284627-qvz63m93 127 6 finding finding NN cord-284627-qvz63m93 127 7 is be VBZ cord-284627-qvz63m93 127 8 from from IN cord-284627-qvz63m93 127 9 Shenzhen Shenzhen NNP cord-284627-qvz63m93 127 10 which which WDT cord-284627-qvz63m93 127 11 showed show VBD cord-284627-qvz63m93 127 12 possible possible JJ cord-284627-qvz63m93 127 13 generation generation NN cord-284627-qvz63m93 127 14 of of IN cord-284627-qvz63m93 127 15 new new JJ cord-284627-qvz63m93 127 16 strain strain NN cord-284627-qvz63m93 127 17 which which WDT cord-284627-qvz63m93 127 18 neither neither CC cord-284627-qvz63m93 127 19 belongs belong VBZ cord-284627-qvz63m93 127 20 to to IN cord-284627-qvz63m93 127 21 'S 's NNP cord-284627-qvz63m93 127 22 ' ' '' cord-284627-qvz63m93 127 23 nor nor CC cord-284627-qvz63m93 127 24 to to TO cord-284627-qvz63m93 127 25 ' ' `` cord-284627-qvz63m93 127 26 L l NN cord-284627-qvz63m93 127 27 ' ' '' cord-284627-qvz63m93 127 28 subtype subtype NN cord-284627-qvz63m93 127 29 . . . cord-284627-qvz63m93 128 1 12 12 CD cord-284627-qvz63m93 129 1 We -PRON- PRP cord-284627-qvz63m93 129 2 evaluated evaluate VBD cord-284627-qvz63m93 129 3 the the DT cord-284627-qvz63m93 129 4 extent extent NN cord-284627-qvz63m93 129 5 of of IN cord-284627-qvz63m93 129 6 molecular molecular JJ cord-284627-qvz63m93 129 7 divergence divergence NN cord-284627-qvz63m93 129 8 by by IN cord-284627-qvz63m93 129 9 MSA MSA NNP cord-284627-qvz63m93 129 10 and and CC cord-284627-qvz63m93 129 11 Pair Pair NNP cord-284627-qvz63m93 129 12 - - HYPH cord-284627-qvz63m93 129 13 wise wise JJ cord-284627-qvz63m93 129 14 alignment alignment NN cord-284627-qvz63m93 129 15 and and CC cord-284627-qvz63m93 129 16 subsequently subsequently RB cord-284627-qvz63m93 129 17 tried try VBD cord-284627-qvz63m93 129 18 to to TO cord-284627-qvz63m93 129 19 decipher decipher VB cord-284627-qvz63m93 129 20 the the DT cord-284627-qvz63m93 129 21 protein protein NN cord-284627-qvz63m93 129 22 alteration alteration NN cord-284627-qvz63m93 129 23 parallel parallel JJ cord-284627-qvz63m93 129 24 to to IN cord-284627-qvz63m93 129 25 the the DT cord-284627-qvz63m93 129 26 mutations mutation NNS cord-284627-qvz63m93 129 27 . . . cord-284627-qvz63m93 130 1 As as IN cord-284627-qvz63m93 130 2 a a DT cord-284627-qvz63m93 130 3 RNA RNA NNP cord-284627-qvz63m93 130 4 virus virus NN cord-284627-qvz63m93 130 5 , , , cord-284627-qvz63m93 130 6 it -PRON- PRP cord-284627-qvz63m93 130 7 was be VBD cord-284627-qvz63m93 130 8 hypothesized hypothesize VBN cord-284627-qvz63m93 130 9 that that IN cord-284627-qvz63m93 130 10 2019-nCoV 2019-ncov CD cord-284627-qvz63m93 130 11 mutate mutate VB cord-284627-qvz63m93 130 12 faster fast RBR cord-284627-qvz63m93 130 13 than than IN cord-284627-qvz63m93 130 14 DNA dna NN cord-284627-qvz63m93 130 15 virus virus NN cord-284627-qvz63m93 130 16 . . . cord-284627-qvz63m93 131 1 12 12 CD cord-284627-qvz63m93 132 1 The the DT cord-284627-qvz63m93 132 2 genome genome NN cord-284627-qvz63m93 132 3 - - HYPH cord-284627-qvz63m93 132 4 wide wide JJ cord-284627-qvz63m93 132 5 phylogenetic phylogenetic JJ cord-284627-qvz63m93 132 6 tree tree NN cord-284627-qvz63m93 132 7 indicated indicate VBD cord-284627-qvz63m93 132 8 that that IN cord-284627-qvz63m93 132 9 2019-nCoV 2019-ncov CD cord-284627-qvz63m93 132 10 was be VBD cord-284627-qvz63m93 132 11 closest close JJS cord-284627-qvz63m93 132 12 to to IN cord-284627-qvz63m93 132 13 SARS SARS NNP cord-284627-qvz63m93 132 14 - - HYPH cord-284627-qvz63m93 132 15 like like JJ cord-284627-qvz63m93 132 16 coronavirus coronavirus NN cord-284627-qvz63m93 132 17 , , , cord-284627-qvz63m93 132 18 with with IN cord-284627-qvz63m93 132 19 96 96 CD cord-284627-qvz63m93 132 20 % % NN cord-284627-qvz63m93 132 21 sequence sequence NN cord-284627-qvz63m93 132 22 similarity similarity NN cord-284627-qvz63m93 132 23 . . . cord-284627-qvz63m93 133 1 20,21 20,21 CD cord-284627-qvz63m93 134 1 When when WRB cord-284627-qvz63m93 134 2 we -PRON- PRP cord-284627-qvz63m93 134 3 evaluated evaluate VBD cord-284627-qvz63m93 134 4 the the DT cord-284627-qvz63m93 134 5 SARS SARS NNP cord-284627-qvz63m93 134 6 - - HYPH cord-284627-qvz63m93 134 7 CoV CoV NNP cord-284627-qvz63m93 134 8 ( ( -LRB- cord-284627-qvz63m93 134 9 2003 2003 CD cord-284627-qvz63m93 134 10 ) ) -RRB- cord-284627-qvz63m93 134 11 and and CC cord-284627-qvz63m93 134 12 SARS SARS NNP cord-284627-qvz63m93 134 13 - - HYPH cord-284627-qvz63m93 134 14 CoV-2 CoV-2 NNP cord-284627-qvz63m93 134 15 ( ( -LRB- cord-284627-qvz63m93 134 16 2020 2020 CD cord-284627-qvz63m93 134 17 ) ) -RRB- cord-284627-qvz63m93 134 18 from from IN cord-284627-qvz63m93 134 19 Italy Italy NNP cord-284627-qvz63m93 134 20 , , , cord-284627-qvz63m93 134 21 sequence sequence NN cord-284627-qvz63m93 134 22 identity identity NN cord-284627-qvz63m93 134 23 was be VBD cord-284627-qvz63m93 134 24 79.4 79.4 CD cord-284627-qvz63m93 134 25 % % NN cord-284627-qvz63m93 134 26 , , , cord-284627-qvz63m93 134 27 suggesting suggest VBG cord-284627-qvz63m93 134 28 new new JJ cord-284627-qvz63m93 134 29 mutations mutation NNS cord-284627-qvz63m93 134 30 , , , cord-284627-qvz63m93 134 31 might may MD cord-284627-qvz63m93 134 32 be be VB cord-284627-qvz63m93 134 33 deleterious deleterious JJ cord-284627-qvz63m93 134 34 in in IN cord-284627-qvz63m93 134 35 later later JJ cord-284627-qvz63m93 134 36 strain strain NN cord-284627-qvz63m93 134 37 . . . cord-284627-qvz63m93 135 1 Our -PRON- PRP$ cord-284627-qvz63m93 135 2 first first JJ cord-284627-qvz63m93 135 3 approach approach NN cord-284627-qvz63m93 135 4 was be VBD cord-284627-qvz63m93 135 5 to to TO cord-284627-qvz63m93 135 6 categorize categorize VB cord-284627-qvz63m93 135 7 the the DT cord-284627-qvz63m93 135 8 countries country NNS cord-284627-qvz63m93 135 9 depending depend VBG cord-284627-qvz63m93 135 10 on on IN cord-284627-qvz63m93 135 11 number number NN cord-284627-qvz63m93 135 12 of of IN cord-284627-qvz63m93 135 13 mutations mutation NNS cord-284627-qvz63m93 135 14 and and CC cord-284627-qvz63m93 135 15 type type NN cord-284627-qvz63m93 135 16 of of IN cord-284627-qvz63m93 135 17 mutation mutation NN cord-284627-qvz63m93 135 18 they -PRON- PRP cord-284627-qvz63m93 135 19 had have VBD cord-284627-qvz63m93 135 20 . . . cord-284627-qvz63m93 136 1 It -PRON- PRP cord-284627-qvz63m93 136 2 was be VBD cord-284627-qvz63m93 136 3 found find VBN cord-284627-qvz63m93 136 4 that that IN cord-284627-qvz63m93 136 5 similar similar JJ cord-284627-qvz63m93 136 6 number number NN cord-284627-qvz63m93 136 7 of of IN cord-284627-qvz63m93 136 8 mutations mutation NNS cord-284627-qvz63m93 136 9 does do VBZ cord-284627-qvz63m93 136 10 not not RB cord-284627-qvz63m93 136 11 correlate correlate VB cord-284627-qvz63m93 136 12 well well RB cord-284627-qvz63m93 136 13 with with IN cord-284627-qvz63m93 136 14 similar similar JJ cord-284627-qvz63m93 136 15 extent extent NN cord-284627-qvz63m93 136 16 of of IN cord-284627-qvz63m93 136 17 fatality fatality NN cord-284627-qvz63m93 136 18 outcome outcome NN cord-284627-qvz63m93 136 19 . . . cord-284627-qvz63m93 137 1 Example example NN cord-284627-qvz63m93 137 2 , , , cord-284627-qvz63m93 137 3 patients patient NNS cord-284627-qvz63m93 137 4 from from IN cord-284627-qvz63m93 137 5 Australia Australia NNP cord-284627-qvz63m93 137 6 , , , cord-284627-qvz63m93 137 7 Japan Japan NNP cord-284627-qvz63m93 137 8 and and CC cord-284627-qvz63m93 137 9 Italy Italy NNP cord-284627-qvz63m93 137 10 all all DT cord-284627-qvz63m93 137 11 show show VBP cord-284627-qvz63m93 137 12 3 3 CD cord-284627-qvz63m93 137 13 mutations mutation NNS cord-284627-qvz63m93 137 14 in in IN cord-284627-qvz63m93 137 15 the the DT cord-284627-qvz63m93 137 16 viral viral JJ cord-284627-qvz63m93 137 17 genome genome NN cord-284627-qvz63m93 137 18 , , , cord-284627-qvz63m93 137 19 but but CC cord-284627-qvz63m93 137 20 Australia Australia NNP cord-284627-qvz63m93 137 21 has have VBZ cord-284627-qvz63m93 137 22 least least JJS cord-284627-qvz63m93 137 23 fatality fatality NN cord-284627-qvz63m93 137 24 rate rate NN cord-284627-qvz63m93 137 25 , , , cord-284627-qvz63m93 137 26 while while IN cord-284627-qvz63m93 137 27 Italy Italy NNP cord-284627-qvz63m93 137 28 has have VBZ cord-284627-qvz63m93 137 29 maximum maximum NN cord-284627-qvz63m93 137 30 . . . cord-284627-qvz63m93 138 1 Again again RB cord-284627-qvz63m93 138 2 , , , cord-284627-qvz63m93 138 3 numbers number NNS cord-284627-qvz63m93 138 4 of of IN cord-284627-qvz63m93 138 5 mutations mutation NNS cord-284627-qvz63m93 138 6 are be VBP cord-284627-qvz63m93 138 7 5 5 CD cord-284627-qvz63m93 138 8 in in IN cord-284627-qvz63m93 138 9 China China NNP cord-284627-qvz63m93 138 10 , , , cord-284627-qvz63m93 138 11 6 6 CD cord-284627-qvz63m93 138 12 in in IN cord-284627-qvz63m93 138 13 India India NNP cord-284627-qvz63m93 138 14 and and CC cord-284627-qvz63m93 138 15 7 7 CD cord-284627-qvz63m93 138 16 in in IN cord-284627-qvz63m93 138 17 both both CC cord-284627-qvz63m93 138 18 Sweden Sweden NNP cord-284627-qvz63m93 138 19 and and CC cord-284627-qvz63m93 138 20 Spain Spain NNP cord-284627-qvz63m93 138 21 . . . cord-284627-qvz63m93 139 1 The the DT cord-284627-qvz63m93 139 2 observations observation NNS cord-284627-qvz63m93 139 3 mentioned mention VBN cord-284627-qvz63m93 139 4 above above IN cord-284627-qvz63m93 139 5 strongly strongly RB cord-284627-qvz63m93 139 6 indicate indicate VBP cord-284627-qvz63m93 139 7 that that IN cord-284627-qvz63m93 139 8 not not RB cord-284627-qvz63m93 139 9 the the DT cord-284627-qvz63m93 139 10 total total JJ cord-284627-qvz63m93 139 11 number number NN cord-284627-qvz63m93 139 12 of of IN cord-284627-qvz63m93 139 13 mutation mutation NN cord-284627-qvz63m93 139 14 , , , cord-284627-qvz63m93 139 15 but but CC cord-284627-qvz63m93 139 16 the the DT cord-284627-qvz63m93 139 17 nature nature NN cord-284627-qvz63m93 139 18 of of IN cord-284627-qvz63m93 139 19 mutations mutation NNS cord-284627-qvz63m93 139 20 finally finally RB cord-284627-qvz63m93 139 21 guides guide VBZ cord-284627-qvz63m93 139 22 the the DT cord-284627-qvz63m93 139 23 overall overall JJ cord-284627-qvz63m93 139 24 fatality fatality NN cord-284627-qvz63m93 139 25 outcome outcome NN cord-284627-qvz63m93 139 26 . . . cord-284627-qvz63m93 140 1 In in IN cord-284627-qvz63m93 140 2 the the DT cord-284627-qvz63m93 140 3 case case NN cord-284627-qvz63m93 140 4 of of IN cord-284627-qvz63m93 140 5 Italy Italy NNP cord-284627-qvz63m93 140 6 , , , cord-284627-qvz63m93 140 7 we -PRON- PRP cord-284627-qvz63m93 140 8 found find VBD cord-284627-qvz63m93 140 9 three three CD cord-284627-qvz63m93 140 10 deadly deadly JJ cord-284627-qvz63m93 140 11 mutations mutation NNS cord-284627-qvz63m93 140 12 in in IN cord-284627-qvz63m93 140 13 2020 2020 CD cord-284627-qvz63m93 141 1 ( ( -LRB- cord-284627-qvz63m93 141 2 i.e. i.e. FW cord-284627-qvz63m93 141 3 2269 2269 CD cord-284627-qvz63m93 141 4 A a NN cord-284627-qvz63m93 142 1 > > XX cord-284627-qvz63m93 142 2 T T NNP cord-284627-qvz63m93 142 3 , , , cord-284627-qvz63m93 142 4 very very RB cord-284627-qvz63m93 142 5 rare rare JJ cord-284627-qvz63m93 142 6 allele allele NN cord-284627-qvz63m93 142 7 ; ; . cord-284627-qvz63m93 143 1 11083 11083 CD cord-284627-qvz63m93 143 2 G g NN cord-284627-qvz63m93 143 3 > > XX cord-284627-qvz63m93 143 4 A a DT cord-284627-qvz63m93 143 5 , , , cord-284627-qvz63m93 143 6 very very RB cord-284627-qvz63m93 143 7 rare rare JJ cord-284627-qvz63m93 143 8 allele allele NN cord-284627-qvz63m93 143 9 and and CC cord-284627-qvz63m93 143 10 26144 26144 CD cord-284627-qvz63m93 143 11 G g NN cord-284627-qvz63m93 143 12 > > XX cord-284627-qvz63m93 143 13 T T NNP cord-284627-qvz63m93 143 14 ) ) -RRB- cord-284627-qvz63m93 143 15 with with IN cord-284627-qvz63m93 143 16 high high JJ cord-284627-qvz63m93 143 17 disease disease NN cord-284627-qvz63m93 143 18 outcome outcome NN cord-284627-qvz63m93 143 19 but but CC cord-284627-qvz63m93 143 20 the the DT cord-284627-qvz63m93 143 21 wild wild JJ cord-284627-qvz63m93 143 22 counterpart counterpart NN cord-284627-qvz63m93 143 23 of of IN cord-284627-qvz63m93 143 24 these these DT cord-284627-qvz63m93 143 25 found find VBN cord-284627-qvz63m93 143 26 in in IN cord-284627-qvz63m93 143 27 2003 2003 CD cord-284627-qvz63m93 143 28 did do VBD cord-284627-qvz63m93 143 29 not not RB cord-284627-qvz63m93 143 30 lead lead VB cord-284627-qvz63m93 143 31 to to IN cord-284627-qvz63m93 143 32 any any DT cord-284627-qvz63m93 143 33 fatality fatality NN cord-284627-qvz63m93 143 34 , , , cord-284627-qvz63m93 143 35 suggesting suggest VBG cord-284627-qvz63m93 143 36 the the DT cord-284627-qvz63m93 143 37 significance significance NN cord-284627-qvz63m93 143 38 of of IN cord-284627-qvz63m93 143 39 newly newly RB cord-284627-qvz63m93 143 40 evolved evolve VBN cord-284627-qvz63m93 143 41 mutations mutation NNS cord-284627-qvz63m93 143 42 . . . cord-284627-qvz63m93 144 1 Although although IN cord-284627-qvz63m93 144 2 , , , cord-284627-qvz63m93 144 3 2269 2269 CD cord-284627-qvz63m93 144 4 A a NN cord-284627-qvz63m93 144 5 > > XX cord-284627-qvz63m93 144 6 T t NN cord-284627-qvz63m93 144 7 mutation mutation NN cord-284627-qvz63m93 144 8 does do VBZ cord-284627-qvz63m93 144 9 not not RB cord-284627-qvz63m93 144 10 alter alter VB cord-284627-qvz63m93 144 11 amino amino NN cord-284627-qvz63m93 144 12 acid acid NN cord-284627-qvz63m93 144 13 ( ( -LRB- cord-284627-qvz63m93 144 14 A668A A668A NNP cord-284627-qvz63m93 144 15 ) ) -RRB- cord-284627-qvz63m93 144 16 , , , cord-284627-qvz63m93 144 17 increasing increase VBG cord-284627-qvz63m93 144 18 number number NN cord-284627-qvz63m93 144 19 of of IN cord-284627-qvz63m93 144 20 evidences evidence NNS cord-284627-qvz63m93 144 21 suggest suggest VBP cord-284627-qvz63m93 144 22 that that IN cord-284627-qvz63m93 144 23 synonymous synonymous JJ cord-284627-qvz63m93 144 24 mutations mutation NNS cord-284627-qvz63m93 144 25 could could MD cord-284627-qvz63m93 144 26 have have VB cord-284627-qvz63m93 144 27 effects effect NNS cord-284627-qvz63m93 144 28 on on IN cord-284627-qvz63m93 144 29 splicing splicing NN cord-284627-qvz63m93 144 30 , , , cord-284627-qvz63m93 144 31 transcription transcription NN cord-284627-qvz63m93 144 32 , , , cord-284627-qvz63m93 144 33 that that WDT cord-284627-qvz63m93 144 34 ultimately ultimately RB cord-284627-qvz63m93 144 35 alter alter VBP cord-284627-qvz63m93 144 36 the the DT cord-284627-qvz63m93 144 37 phenotype phenotype NN cord-284627-qvz63m93 144 38 , , , cord-284627-qvz63m93 144 39 disrupting disrupt VBG cord-284627-qvz63m93 144 40 their -PRON- PRP$ cord-284627-qvz63m93 144 41 silence silence NN cord-284627-qvz63m93 144 42 . . . cord-284627-qvz63m93 145 1 22 22 CD cord-284627-qvz63m93 146 1 Spain Spain NNP cord-284627-qvz63m93 146 2 is be VBZ cord-284627-qvz63m93 146 3 also also RB cord-284627-qvz63m93 146 4 carrying carry VBG cord-284627-qvz63m93 146 5 a a DT cord-284627-qvz63m93 146 6 very very RB cord-284627-qvz63m93 146 7 rare rare JJ cord-284627-qvz63m93 146 8 allele allele NN cord-284627-qvz63m93 146 9 transversion transversion NN cord-284627-qvz63m93 146 10 T T NNP cord-284627-qvz63m93 146 11 > > XX cord-284627-qvz63m93 147 1 A a LS cord-284627-qvz63m93 147 2 , , , cord-284627-qvz63m93 147 3 that that DT cord-284627-qvz63m93 147 4 occurs occur VBZ cord-284627-qvz63m93 147 5 in in IN cord-284627-qvz63m93 147 6 orf1ab orf1ab CD cord-284627-qvz63m93 147 7 gene gene NN cord-284627-qvz63m93 147 8 of of IN cord-284627-qvz63m93 147 9 virus virus NN cord-284627-qvz63m93 147 10 . . . cord-284627-qvz63m93 148 1 Orf1ab orf1ab NN cord-284627-qvz63m93 148 2 gene gene NN cord-284627-qvz63m93 148 3 transcribes transcribe VBZ cord-284627-qvz63m93 148 4 into into IN cord-284627-qvz63m93 148 5 a a DT cord-284627-qvz63m93 148 6 polyprotein polyprotein NN cord-284627-qvz63m93 148 7 and and CC cord-284627-qvz63m93 148 8 cleaving cleaving NN cord-284627-qvz63m93 148 9 by by IN cord-284627-qvz63m93 148 10 protease protease NN cord-284627-qvz63m93 148 11 ( ( -LRB- cord-284627-qvz63m93 148 12 3CLpro 3clpro CD cord-284627-qvz63m93 148 13 ) ) -RRB- cord-284627-qvz63m93 148 14 and and CC cord-284627-qvz63m93 148 15 papain papain NN cord-284627-qvz63m93 148 16 - - HYPH cord-284627-qvz63m93 148 17 like like JJ cord-284627-qvz63m93 148 18 protease protease NN cord-284627-qvz63m93 148 19 ( ( -LRB- cord-284627-qvz63m93 148 20 PLpro PLpro NNP cord-284627-qvz63m93 148 21 ) ) -RRB- cord-284627-qvz63m93 149 1 produces produce VBZ cord-284627-qvz63m93 149 2 several several JJ cord-284627-qvz63m93 149 3 non non JJ cord-284627-qvz63m93 149 4 - - JJ cord-284627-qvz63m93 149 5 structural structural JJ cord-284627-qvz63m93 149 6 proteins protein NNS cord-284627-qvz63m93 149 7 , , , cord-284627-qvz63m93 149 8 which which WDT cord-284627-qvz63m93 149 9 are be VBP cord-284627-qvz63m93 149 10 important important JJ cord-284627-qvz63m93 149 11 for for IN cord-284627-qvz63m93 149 12 replication replication NN cord-284627-qvz63m93 149 13 as as RB cord-284627-qvz63m93 149 14 well well RB cord-284627-qvz63m93 149 15 as as IN cord-284627-qvz63m93 149 16 virulence virulence NN cord-284627-qvz63m93 149 17 for for IN cord-284627-qvz63m93 149 18 coronavirus coronavirus NN cord-284627-qvz63m93 149 19 . . . cord-284627-qvz63m93 150 1 Thus thus RB cord-284627-qvz63m93 150 2 , , , cord-284627-qvz63m93 150 3 an an DT cord-284627-qvz63m93 150 4 alteration alteration NN cord-284627-qvz63m93 150 5 in in IN cord-284627-qvz63m93 150 6 this this DT cord-284627-qvz63m93 150 7 region region NN cord-284627-qvz63m93 150 8 might may MD cord-284627-qvz63m93 150 9 alter alter VB cord-284627-qvz63m93 150 10 the the DT cord-284627-qvz63m93 150 11 virulence virulence NN cord-284627-qvz63m93 150 12 , , , cord-284627-qvz63m93 150 13 and and CC cord-284627-qvz63m93 150 14 associated associated JJ cord-284627-qvz63m93 150 15 fatality fatality NN cord-284627-qvz63m93 150 16 outcome outcome NN cord-284627-qvz63m93 150 17 . . . cord-284627-qvz63m93 151 1 We -PRON- PRP cord-284627-qvz63m93 151 2 assume assume VBP cord-284627-qvz63m93 151 3 , , , cord-284627-qvz63m93 151 4 while while IN cord-284627-qvz63m93 151 5 some some DT cord-284627-qvz63m93 151 6 mutations mutation NNS cord-284627-qvz63m93 151 7 are be VBP cord-284627-qvz63m93 151 8 pathogenic pathogenic JJ cord-284627-qvz63m93 151 9 , , , cord-284627-qvz63m93 151 10 some some DT cord-284627-qvz63m93 151 11 will will MD cord-284627-qvz63m93 151 12 be be VB cord-284627-qvz63m93 151 13 favorable favorable JJ cord-284627-qvz63m93 151 14 and and CC cord-284627-qvz63m93 151 15 will will MD cord-284627-qvz63m93 151 16 undergo undergo VB cord-284627-qvz63m93 151 17 positive positive JJ cord-284627-qvz63m93 151 18 selection selection NN cord-284627-qvz63m93 151 19 pressure pressure NN cord-284627-qvz63m93 151 20 . . . cord-284627-qvz63m93 152 1 Herein herein RB cord-284627-qvz63m93 152 2 , , , cord-284627-qvz63m93 152 3 we -PRON- PRP cord-284627-qvz63m93 152 4 tried try VBD cord-284627-qvz63m93 152 5 to to TO cord-284627-qvz63m93 152 6 elucidate elucidate VB cord-284627-qvz63m93 152 7 the the DT cord-284627-qvz63m93 152 8 possible possible JJ cord-284627-qvz63m93 152 9 interaction interaction NN cord-284627-qvz63m93 152 10 between between IN cord-284627-qvz63m93 152 11 ACE2 ACE2 NNP cord-284627-qvz63m93 152 12 and and CC cord-284627-qvz63m93 152 13 spike spike NN cord-284627-qvz63m93 152 14 glycoprotein glycoprotein NN cord-284627-qvz63m93 152 15 . . . cord-284627-qvz63m93 153 1 It -PRON- PRP cord-284627-qvz63m93 153 2 is be VBZ cord-284627-qvz63m93 153 3 well well RB cord-284627-qvz63m93 153 4 established establish VBN cord-284627-qvz63m93 153 5 that that IN cord-284627-qvz63m93 153 6 for for IN cord-284627-qvz63m93 153 7 virus virus NN cord-284627-qvz63m93 153 8 entry entry NN cord-284627-qvz63m93 153 9 , , , cord-284627-qvz63m93 153 10 spike spike NN cord-284627-qvz63m93 153 11 glycoprotein glycoprotein NN cord-284627-qvz63m93 153 12 ( ( -LRB- cord-284627-qvz63m93 153 13 S s NN cord-284627-qvz63m93 153 14 ) ) -RRB- cord-284627-qvz63m93 154 1 present present JJ cord-284627-qvz63m93 154 2 on on IN cord-284627-qvz63m93 154 3 the the DT cord-284627-qvz63m93 154 4 CoV cov NN cord-284627-qvz63m93 154 5 can can MD cord-284627-qvz63m93 154 6 be be VB cord-284627-qvz63m93 154 7 a a DT cord-284627-qvz63m93 154 8 neutralization neutralization NN cord-284627-qvz63m93 154 9 antibody antibody NN cord-284627-qvz63m93 154 10 and and CC cord-284627-qvz63m93 154 11 it -PRON- PRP cord-284627-qvz63m93 154 12 binds bind VBZ cord-284627-qvz63m93 154 13 to to IN cord-284627-qvz63m93 154 14 its -PRON- PRP$ cord-284627-qvz63m93 154 15 receptor receptor NN cord-284627-qvz63m93 154 16 followed follow VBN cord-284627-qvz63m93 154 17 by by IN cord-284627-qvz63m93 154 18 membrane membrane NN cord-284627-qvz63m93 154 19 fusion fusion NN cord-284627-qvz63m93 154 20 . . . cord-284627-qvz63m93 155 1 It -PRON- PRP cord-284627-qvz63m93 155 2 has have VBZ cord-284627-qvz63m93 155 3 been be VBN cord-284627-qvz63m93 155 4 inferred infer VBN cord-284627-qvz63m93 155 5 that that IN cord-284627-qvz63m93 155 6 some some DT cord-284627-qvz63m93 155 7 favorable favorable JJ cord-284627-qvz63m93 155 8 changes change NNS cord-284627-qvz63m93 155 9 in in IN cord-284627-qvz63m93 155 10 viral viral JJ cord-284627-qvz63m93 155 11 glycoprotein glycoprotein NN cord-284627-qvz63m93 155 12 may may MD cord-284627-qvz63m93 155 13 limit limit VB cord-284627-qvz63m93 155 14 the the DT cord-284627-qvz63m93 155 15 increase increase NN cord-284627-qvz63m93 155 16 of of IN cord-284627-qvz63m93 155 17 fatality fatality NN cord-284627-qvz63m93 155 18 . . . cord-284627-qvz63m93 156 1 This this DT cord-284627-qvz63m93 156 2 kind kind NN cord-284627-qvz63m93 156 3 of of IN cord-284627-qvz63m93 156 4 favorable favorable JJ cord-284627-qvz63m93 156 5 mutation mutation NN cord-284627-qvz63m93 156 6 was be VBD cord-284627-qvz63m93 156 7 found find VBN cord-284627-qvz63m93 156 8 in in IN cord-284627-qvz63m93 156 9 some some DT cord-284627-qvz63m93 156 10 strains strain NNS cord-284627-qvz63m93 156 11 of of IN cord-284627-qvz63m93 156 12 COVID-19 COVID-19 NNP cord-284627-qvz63m93 156 13 from from IN cord-284627-qvz63m93 156 14 India India NNP cord-284627-qvz63m93 156 15 , , , cord-284627-qvz63m93 156 16 Australia Australia NNP cord-284627-qvz63m93 156 17 and and CC cord-284627-qvz63m93 156 18 Sweden Sweden NNP cord-284627-qvz63m93 156 19 . . . cord-284627-qvz63m93 157 1 Detailed detailed JJ cord-284627-qvz63m93 157 2 screening screening NN cord-284627-qvz63m93 157 3 depicted depict VBD cord-284627-qvz63m93 157 4 that that IN cord-284627-qvz63m93 157 5 Australian australian JJ cord-284627-qvz63m93 157 6 strain strain NN cord-284627-qvz63m93 157 7 carry carry VBP cord-284627-qvz63m93 157 8 a a DT cord-284627-qvz63m93 157 9 rare rare JJ cord-284627-qvz63m93 157 10 allele allele NN cord-284627-qvz63m93 157 11 transversion transversion NN cord-284627-qvz63m93 157 12 ( ( -LRB- cord-284627-qvz63m93 157 13 T t NN cord-284627-qvz63m93 157 14 > > XX cord-284627-qvz63m93 157 15 G g NN cord-284627-qvz63m93 157 16 ) ) -RRB- cord-284627-qvz63m93 157 17 which which WDT cord-284627-qvz63m93 157 18 results result VBZ cord-284627-qvz63m93 157 19 into into IN cord-284627-qvz63m93 157 20 a a DT cord-284627-qvz63m93 157 21 NS NS NNP cord-284627-qvz63m93 157 22 mutation mutation NN cord-284627-qvz63m93 157 23 ( ( -LRB- cord-284627-qvz63m93 157 24 S256R S256R NNP cord-284627-qvz63m93 157 25 ) ) -RRB- cord-284627-qvz63m93 157 26 on on IN cord-284627-qvz63m93 157 27 surface surface NN cord-284627-qvz63m93 157 28 glycoprotein glycoprotein NN cord-284627-qvz63m93 157 29 S1 s1 NN cord-284627-qvz63m93 157 30 domain domain NN cord-284627-qvz63m93 157 31 which which WDT cord-284627-qvz63m93 157 32 may may MD cord-284627-qvz63m93 157 33 affect affect VB cord-284627-qvz63m93 157 34 the the DT cord-284627-qvz63m93 157 35 binding binding NN cord-284627-qvz63m93 157 36 of of IN cord-284627-qvz63m93 157 37 hACE2 hace2 NN cord-284627-qvz63m93 157 38 molecules molecule NNS cord-284627-qvz63m93 157 39 , , , cord-284627-qvz63m93 157 40 thus thus RB cord-284627-qvz63m93 157 41 these these DT cord-284627-qvz63m93 157 42 strains strain NNS cord-284627-qvz63m93 157 43 become become VBP cord-284627-qvz63m93 157 44 non non JJ cord-284627-qvz63m93 157 45 - - JJ cord-284627-qvz63m93 157 46 lethal lethal JJ cord-284627-qvz63m93 157 47 to to IN cord-284627-qvz63m93 157 48 human human NN cord-284627-qvz63m93 157 49 . . . cord-284627-qvz63m93 158 1 In in IN cord-284627-qvz63m93 158 2 this this DT cord-284627-qvz63m93 158 3 study study NN cord-284627-qvz63m93 158 4 , , , cord-284627-qvz63m93 158 5 only only RB cord-284627-qvz63m93 158 6 one one CD cord-284627-qvz63m93 158 7 tri tri JJ cord-284627-qvz63m93 158 8 - - JJ cord-284627-qvz63m93 158 9 nucleotide nucleotide JJ cord-284627-qvz63m93 158 10 deletion deletion NN cord-284627-qvz63m93 158 11 at at IN cord-284627-qvz63m93 158 12 S1 s1 NN cord-284627-qvz63m93 158 13 domain domain NN cord-284627-qvz63m93 158 14 of of IN cord-284627-qvz63m93 158 15 surface surface NN cord-284627-qvz63m93 158 16 glycoprotein glycoprotein NN cord-284627-qvz63m93 158 17 has have VBZ cord-284627-qvz63m93 158 18 been be VBN cord-284627-qvz63m93 158 19 found find VBN cord-284627-qvz63m93 158 20 and and CC cord-284627-qvz63m93 158 21 that that DT cord-284627-qvz63m93 158 22 is be VBZ cord-284627-qvz63m93 158 23 found find VBN cord-284627-qvz63m93 158 24 in in IN cord-284627-qvz63m93 158 25 Indian indian JJ cord-284627-qvz63m93 158 26 strains strain NNS cord-284627-qvz63m93 158 27 along along IN cord-284627-qvz63m93 158 28 with with IN cord-284627-qvz63m93 158 29 a a DT cord-284627-qvz63m93 158 30 NS NS NNP cord-284627-qvz63m93 158 31 mutation mutation NN cord-284627-qvz63m93 158 32 ( ( -LRB- cord-284627-qvz63m93 158 33 R417I R417I NNP cord-284627-qvz63m93 158 34 ) ) -RRB- cord-284627-qvz63m93 158 35 in in IN cord-284627-qvz63m93 158 36 the the DT cord-284627-qvz63m93 158 37 Receptor Receptor NNP cord-284627-qvz63m93 158 38 Binding Binding NNP cord-284627-qvz63m93 158 39 Domain Domain NNP cord-284627-qvz63m93 158 40 ( ( -LRB- cord-284627-qvz63m93 158 41 RBD RBD NNP cord-284627-qvz63m93 158 42 ) ) -RRB- cord-284627-qvz63m93 158 43 of of IN cord-284627-qvz63m93 158 44 S1 s1 NN cord-284627-qvz63m93 158 45 subunit subunit NN cord-284627-qvz63m93 158 46 that that WDT cord-284627-qvz63m93 158 47 disfavor disfavor VBP cord-284627-qvz63m93 158 48 viral viral JJ cord-284627-qvz63m93 158 49 entry entry NN cord-284627-qvz63m93 158 50 by by IN cord-284627-qvz63m93 158 51 inhibiting inhibit VBG cord-284627-qvz63m93 158 52 hACE2 hace2 ADD cord-284627-qvz63m93 158 53 interaction interaction NN cord-284627-qvz63m93 158 54 . . . cord-284627-qvz63m93 159 1 On on IN cord-284627-qvz63m93 159 2 the the DT cord-284627-qvz63m93 159 3 other other JJ cord-284627-qvz63m93 159 4 hand hand NN cord-284627-qvz63m93 159 5 , , , cord-284627-qvz63m93 159 6 Brazilian brazilian JJ cord-284627-qvz63m93 159 7 strain strain NN cord-284627-qvz63m93 159 8 acquires acquire VBZ cord-284627-qvz63m93 159 9 four four CD cord-284627-qvz63m93 159 10 common common JJ cord-284627-qvz63m93 159 11 allelic allelic JJ cord-284627-qvz63m93 159 12 transitions transition NNS cord-284627-qvz63m93 159 13 , , , cord-284627-qvz63m93 159 14 of of IN cord-284627-qvz63m93 159 15 which which WDT cord-284627-qvz63m93 159 16 only only RB cord-284627-qvz63m93 159 17 two two CD cord-284627-qvz63m93 159 18 non non JJ cord-284627-qvz63m93 159 19 - - JJ cord-284627-qvz63m93 159 20 synonymous synonymous JJ cord-284627-qvz63m93 159 21 mutations mutation NNS cord-284627-qvz63m93 159 22 affect affect VBP cord-284627-qvz63m93 159 23 protein protein NN cord-284627-qvz63m93 159 24 alteration alteration NN cord-284627-qvz63m93 159 25 . . . cord-284627-qvz63m93 160 1 Surprisingly surprisingly RB cord-284627-qvz63m93 160 2 , , , cord-284627-qvz63m93 160 3 Swedish swedish JJ cord-284627-qvz63m93 160 4 strain strain NN cord-284627-qvz63m93 160 5 carry carry VBP cord-284627-qvz63m93 160 6 both both CC cord-284627-qvz63m93 160 7 extreme extreme JJ cord-284627-qvz63m93 160 8 lethal lethal NN cord-284627-qvz63m93 160 9 ( ( -LRB- cord-284627-qvz63m93 160 10 2717 2717 CD cord-284627-qvz63m93 160 11 G g NN cord-284627-qvz63m93 160 12 > > XX cord-284627-qvz63m93 160 13 A a NN cord-284627-qvz63m93 160 14 , , , cord-284627-qvz63m93 160 15 very very RB cord-284627-qvz63m93 160 16 rare rare JJ cord-284627-qvz63m93 160 17 allele allele NN cord-284627-qvz63m93 160 18 leading lead VBG cord-284627-qvz63m93 160 19 to to IN cord-284627-qvz63m93 160 20 G818S g818s ADD cord-284627-qvz63m93 160 21 at at IN cord-284627-qvz63m93 160 22 Orf1ab Orf1ab NNP cord-284627-qvz63m93 160 23 polyprotein polyprotein NNP cord-284627-qvz63m93 160 24 ) ) -RRB- cord-284627-qvz63m93 160 25 and and CC cord-284627-qvz63m93 160 26 also also RB cord-284627-qvz63m93 160 27 favorable favorable JJ cord-284627-qvz63m93 160 28 mutations mutation NNS cord-284627-qvz63m93 160 29 ( ( -LRB- cord-284627-qvz63m93 161 1 23952 23952 CD cord-284627-qvz63m93 161 2 T t NN cord-284627-qvz63m93 161 3 > > XX cord-284627-qvz63m93 161 4 G g NN cord-284627-qvz63m93 161 5 , , , cord-284627-qvz63m93 161 6 rare rare JJ cord-284627-qvz63m93 161 7 allele allele NN cord-284627-qvz63m93 161 8 leading lead VBG cord-284627-qvz63m93 161 9 to to IN cord-284627-qvz63m93 161 10 F806C F806C NNP cord-284627-qvz63m93 161 11 at at IN cord-284627-qvz63m93 161 12 surface surface NN cord-284627-qvz63m93 161 13 glycoprotein glycoprotein NN cord-284627-qvz63m93 161 14 ) ) -RRB- cord-284627-qvz63m93 161 15 and and CC cord-284627-qvz63m93 161 16 thus thus RB cord-284627-qvz63m93 161 17 cumulatively cumulatively RB cord-284627-qvz63m93 161 18 lower lower VB cord-284627-qvz63m93 161 19 the the DT cord-284627-qvz63m93 161 20 severity severity NN cord-284627-qvz63m93 161 21 of of IN cord-284627-qvz63m93 161 22 the the DT cord-284627-qvz63m93 161 23 disease disease NN cord-284627-qvz63m93 161 24 . . . cord-284627-qvz63m93 162 1 In in IN cord-284627-qvz63m93 162 2 summary summary NN cord-284627-qvz63m93 162 3 , , , cord-284627-qvz63m93 162 4 the the DT cord-284627-qvz63m93 162 5 present present JJ cord-284627-qvz63m93 162 6 study study NN cord-284627-qvz63m93 162 7 reveals reveal VBZ cord-284627-qvz63m93 162 8 that that IN cord-284627-qvz63m93 162 9 the the DT cord-284627-qvz63m93 162 10 fatality fatality NN cord-284627-qvz63m93 162 11 rate rate NN cord-284627-qvz63m93 162 12 increases increase NNS cord-284627-qvz63m93 162 13 with with IN cord-284627-qvz63m93 162 14 not not RB cord-284627-qvz63m93 162 15 only only RB cord-284627-qvz63m93 162 16 the the DT cord-284627-qvz63m93 162 17 number number NN cord-284627-qvz63m93 162 18 of of IN cord-284627-qvz63m93 162 19 mutations mutation NNS cord-284627-qvz63m93 162 20 but but CC cord-284627-qvz63m93 162 21 also also RB cord-284627-qvz63m93 162 22 depending depend VBG cord-284627-qvz63m93 162 23 on on IN cord-284627-qvz63m93 162 24 its -PRON- PRP$ cord-284627-qvz63m93 162 25 allelic allelic JJ cord-284627-qvz63m93 162 26 rarity rarity NN cord-284627-qvz63m93 162 27 as as RB cord-284627-qvz63m93 162 28 well well RB cord-284627-qvz63m93 162 29 as as IN cord-284627-qvz63m93 162 30 functional functional JJ cord-284627-qvz63m93 162 31 alteration alteration NN cord-284627-qvz63m93 162 32 of of IN cord-284627-qvz63m93 162 33 protein protein NN cord-284627-qvz63m93 162 34 . . . cord-284627-qvz63m93 163 1 Surface surface NN cord-284627-qvz63m93 163 2 glycoprotein glycoprotein NN cord-284627-qvz63m93 163 3 domain domain NN cord-284627-qvz63m93 163 4 is be VBZ cord-284627-qvz63m93 163 5 very very RB cord-284627-qvz63m93 163 6 important important JJ cord-284627-qvz63m93 163 7 for for IN cord-284627-qvz63m93 163 8 host host NN cord-284627-qvz63m93 163 9 - - HYPH cord-284627-qvz63m93 163 10 carrier carrier NN cord-284627-qvz63m93 163 11 interactions interaction NNS cord-284627-qvz63m93 163 12 and and CC cord-284627-qvz63m93 163 13 hence hence RB cord-284627-qvz63m93 163 14 the the DT cord-284627-qvz63m93 163 15 mutations mutation NNS cord-284627-qvz63m93 163 16 affecting affect VBG cord-284627-qvz63m93 163 17 surface surface NN cord-284627-qvz63m93 163 18 glycoprotein glycoprotein NN cord-284627-qvz63m93 163 19 can can MD cord-284627-qvz63m93 163 20 be be VB cord-284627-qvz63m93 163 21 one one CD cord-284627-qvz63m93 163 22 of of IN cord-284627-qvz63m93 163 23 the the DT cord-284627-qvz63m93 163 24 important important JJ cord-284627-qvz63m93 163 25 mechanisms mechanism NNS cord-284627-qvz63m93 163 26 which which WDT cord-284627-qvz63m93 163 27 alter alter VBP cord-284627-qvz63m93 163 28 the the DT cord-284627-qvz63m93 163 29 viral viral JJ cord-284627-qvz63m93 163 30 entry entry NN cord-284627-qvz63m93 163 31 and and CC cord-284627-qvz63m93 163 32 pathogenesis pathogenesis NN cord-284627-qvz63m93 163 33 . . . cord-284627-qvz63m93 164 1 Future future JJ cord-284627-qvz63m93 164 2 studies study NNS cord-284627-qvz63m93 164 3 may may MD cord-284627-qvz63m93 164 4 uncover uncover VB cord-284627-qvz63m93 164 5 more more JJR cord-284627-qvz63m93 164 6 genetic genetic JJ cord-284627-qvz63m93 164 7 information information NN cord-284627-qvz63m93 164 8 at at IN cord-284627-qvz63m93 164 9 the the DT cord-284627-qvz63m93 164 10 molecular molecular JJ cord-284627-qvz63m93 164 11 level level NN cord-284627-qvz63m93 164 12 as as RB cord-284627-qvz63m93 164 13 well well RB cord-284627-qvz63m93 164 14 as as IN cord-284627-qvz63m93 164 15 structural structural JJ cord-284627-qvz63m93 164 16 levels level NNS cord-284627-qvz63m93 164 17 of of IN cord-284627-qvz63m93 164 18 the the DT cord-284627-qvz63m93 164 19 proteins protein NNS cord-284627-qvz63m93 164 20 , , , cord-284627-qvz63m93 164 21 because because IN cord-284627-qvz63m93 164 22 without without IN cord-284627-qvz63m93 164 23 this this DT cord-284627-qvz63m93 164 24 knowledge knowledge NN cord-284627-qvz63m93 164 25 it -PRON- PRP cord-284627-qvz63m93 164 26 'll will MD cord-284627-qvz63m93 164 27 be be VB cord-284627-qvz63m93 164 28 difficult difficult JJ cord-284627-qvz63m93 164 29 to to TO cord-284627-qvz63m93 164 30 identify identify VB cord-284627-qvz63m93 164 31 drug drug NN cord-284627-qvz63m93 164 32 target target NN cord-284627-qvz63m93 164 33 and and CC cord-284627-qvz63m93 164 34 prepare prepare VB cord-284627-qvz63m93 164 35 vaccine vaccine NN cord-284627-qvz63m93 164 36 . . . cord-284627-qvz63m93 165 1 We -PRON- PRP cord-284627-qvz63m93 165 2 hope hope VBP cord-284627-qvz63m93 165 3 our -PRON- PRP$ cord-284627-qvz63m93 165 4 work work NN cord-284627-qvz63m93 165 5 will will MD cord-284627-qvz63m93 165 6 help help VB cord-284627-qvz63m93 165 7 in in IN cord-284627-qvz63m93 165 8 that that DT cord-284627-qvz63m93 165 9 direction direction NN cord-284627-qvz63m93 165 10 . . . cord-284627-qvz63m93 166 1 SB SB NNP cord-284627-qvz63m93 166 2 , , , cord-284627-qvz63m93 166 3 PB PB NNP cord-284627-qvz63m93 166 4 designed design VBD cord-284627-qvz63m93 166 5 the the DT cord-284627-qvz63m93 166 6 study study NN cord-284627-qvz63m93 166 7 ; ; : cord-284627-qvz63m93 166 8 SB SB NNP cord-284627-qvz63m93 166 9 , , , cord-284627-qvz63m93 166 10 SD SD NNP cord-284627-qvz63m93 166 11 analyzed analyze VBD cord-284627-qvz63m93 166 12 the the DT cord-284627-qvz63m93 166 13 data datum NNS cord-284627-qvz63m93 166 14 ; ; : cord-284627-qvz63m93 166 15 SB SB NNP cord-284627-qvz63m93 166 16 , , , cord-284627-qvz63m93 166 17 PB PB NNP cord-284627-qvz63m93 166 18 interpreted interpret VBD cord-284627-qvz63m93 166 19 the the DT cord-284627-qvz63m93 166 20 data datum NNS cord-284627-qvz63m93 166 21 ; ; : cord-284627-qvz63m93 166 22 SB SB NNP cord-284627-qvz63m93 166 23 , , , cord-284627-qvz63m93 166 24 SD SD NNP cord-284627-qvz63m93 166 25 , , , cord-284627-qvz63m93 166 26 SBh SBh NNS cord-284627-qvz63m93 166 27 searched search VBD cord-284627-qvz63m93 166 28 literatures literature NNS cord-284627-qvz63m93 166 29 ; ; : cord-284627-qvz63m93 166 30 SD sd NN cord-284627-qvz63m93 166 31 , , , cord-284627-qvz63m93 166 32 SBh sbh NN cord-284627-qvz63m93 166 33 , , , cord-284627-qvz63m93 166 34 PB PB NNP cord-284627-qvz63m93 166 35 wrote write VBD cord-284627-qvz63m93 166 36 the the DT cord-284627-qvz63m93 166 37 manuscript manuscript NN cord-284627-qvz63m93 166 38 ; ; : cord-284627-qvz63m93 166 39 SD SD NNP cord-284627-qvz63m93 166 40 prepared prepared JJ cord-284627-qvz63m93 166 41 figures figure NNS cord-284627-qvz63m93 166 42 ; ; : cord-284627-qvz63m93 166 43 PB PB NNP cord-284627-qvz63m93 166 44 supervised supervise VBD cord-284627-qvz63m93 166 45 overall overall JJ cord-284627-qvz63m93 166 46 study study NN cord-284627-qvz63m93 166 47 . . . cord-284627-qvz63m93 167 1 We -PRON- PRP cord-284627-qvz63m93 167 2 declare declare VBP cord-284627-qvz63m93 167 3 no no DT cord-284627-qvz63m93 167 4 competing compete VBG cord-284627-qvz63m93 167 5 interests interest NNS cord-284627-qvz63m93 167 6 . . . cord-284627-qvz63m93 168 1 Zhou Zhou NNP cord-284627-qvz63m93 168 2 P P NNP cord-284627-qvz63m93 168 3 , , , cord-284627-qvz63m93 168 4 Yang Yang NNP cord-284627-qvz63m93 168 5 XL XL NNP cord-284627-qvz63m93 168 6 , , , cord-284627-qvz63m93 168 7 Wang Wang NNP cord-284627-qvz63m93 168 8 Common Common NNP cord-284627-qvz63m93 168 9 _SP cord-284627-qvz63m93 168 10 8 8 CD cord-284627-qvz63m93 168 11 _SP cord-284627-qvz63m93 168 12 8782 8782 CD cord-284627-qvz63m93 168 13 _SP cord-284627-qvz63m93 168 14 C C NNP cord-284627-qvz63m93 168 15 _SP cord-284627-qvz63m93 169 1 T T NNP cord-284627-qvz63m93 169 2 _SP cord-284627-qvz63m93 170 1 0·923 0·923 CD cord-284627-qvz63m93 170 2 _SP cord-284627-qvz63m93 171 1 C C NNP cord-284627-qvz63m93 172 1 > > XX cord-284627-qvz63m93 173 1 T T NNP cord-284627-qvz63m93 173 2 _SP cord-284627-qvz63m93 174 1 0·0615 0·0615 NFP cord-284627-qvz63m93 174 2 _SP cord-284627-qvz63m93 175 1 0·375 0·375 CD cord-284627-qvz63m93 175 2 _SP cord-284627-qvz63m93 176 1 1·81 1·81 CD cord-284627-qvz63m93 176 2 _SP cord-284627-qvz63m93 177 1 Very very RB cord-284627-qvz63m93 177 2 _SP cord-284627-qvz63m93 177 3 Common common JJ cord-284627-qvz63m93 177 4 _SP cord-284627-qvz63m93 178 1 9 9 CD cord-284627-qvz63m93 178 2 _SP cord-284627-qvz63m93 179 1 9274 9274 CD cord-284627-qvz63m93 179 2 _SP cord-284627-qvz63m93 180 1 A a DT cord-284627-qvz63m93 180 2 _SP cord-284627-qvz63m93 180 3 G g NN cord-284627-qvz63m93 180 4 _SP cord-284627-qvz63m93 181 1 0·923 0·923 CD cord-284627-qvz63m93 181 2 _SP cord-284627-qvz63m93 182 1 A a DT cord-284627-qvz63m93 183 1 > > XX cord-284627-qvz63m93 183 2 G G NNP cord-284627-qvz63m93 183 3 _SP cord-284627-qvz63m93 183 4 0·0592 0·0592 CD cord-284627-qvz63m93 183 5 _SP cord-284627-qvz63m93 184 1 0·05 0·05 CD cord-284627-qvz63m93 184 2 _SP cord-284627-qvz63m93 184 3 -0·16 -0·16 XX cord-284627-qvz63m93 184 4 _SP cord-284627-qvz63m93 185 1 Rare rare JJ cord-284627-qvz63m93 185 2 _SP cord-284627-qvz63m93 186 1 10 10 CD cord-284627-qvz63m93 186 2 _SP cord-284627-qvz63m93 186 3 9477 9477 CD cord-284627-qvz63m93 186 4 _SP cord-284627-qvz63m93 187 1 T T NNP cord-284627-qvz63m93 187 2 _SP cord-284627-qvz63m93 188 1 A a DT cord-284627-qvz63m93 188 2 _SP cord-284627-qvz63m93 189 1 0·923 0·923 CD cord-284627-qvz63m93 189 2 _SP cord-284627-qvz63m93 189 3 T T NNP cord-284627-qvz63m93 190 1 > > XX cord-284627-qvz63m93 191 1 A a DT cord-284627-qvz63m93 191 2 _SP cord-284627-qvz63m93 192 1 0·0874 0·0874 NFP cord-284627-qvz63m93 192 2 _SP cord-284627-qvz63m93 193 1 0·025 0·025 CD cord-284627-qvz63m93 193 2 _SP cord-284627-qvz63m93 193 3 -1·25 -1·25 HYPH cord-284627-qvz63m93 193 4 _SP cord-284627-qvz63m93 194 1 Very very RB cord-284627-qvz63m93 194 2 _SP cord-284627-qvz63m93 194 3 Rare rare JJ cord-284627-qvz63m93 194 4 _SP cord-284627-qvz63m93 195 1 11 11 CD cord-284627-qvz63m93 195 2 _SP cord-284627-qvz63m93 195 3 10232 10232 CD cord-284627-qvz63m93 195 4 _SP cord-284627-qvz63m93 196 1 C C NNP cord-284627-qvz63m93 196 2 _SP cord-284627-qvz63m93 197 1 T T NNP cord-284627-qvz63m93 197 2 _SP cord-284627-qvz63m93 198 1 0·923 0·923 CD cord-284627-qvz63m93 198 2 _SP cord-284627-qvz63m93 199 1 C C NNP cord-284627-qvz63m93 200 1 > > XX cord-284627-qvz63m93 201 1 T T NNP cord-284627-qvz63m93 201 2 _SP cord-284627-qvz63m93 202 1 0·0615 0·0615 NFP cord-284627-qvz63m93 202 2 _SP cord-284627-qvz63m93 203 1 0·375 0·375 CD cord-284627-qvz63m93 203 2 _SP cord-284627-qvz63m93 204 1 1·81 1·81 CD cord-284627-qvz63m93 204 2 _SP cord-284627-qvz63m93 205 1 Very very RB cord-284627-qvz63m93 205 2 _SP cord-284627-qvz63m93 205 3 Common Common NNP cord-284627-qvz63m93 205 4 _SP cord-284627-qvz63m93 205 5 12 12 CD cord-284627-qvz63m93 205 6 _SP cord-284627-qvz63m93 205 7 11083 11083 CD cord-284627-qvz63m93 205 8 _SP cord-284627-qvz63m93 206 1 G G NNP cord-284627-qvz63m93 206 2 _SP cord-284627-qvz63m93 206 3 T T NNP cord-284627-qvz63m93 206 4 / / SYM cord-284627-qvz63m93 206 5 N N NNP cord-284627-qvz63m93 206 6 _SP cord-284627-qvz63m93 207 1 0·846 0·846 CD cord-284627-qvz63m93 207 2 _SP cord-284627-qvz63m93 208 1 G g NN cord-284627-qvz63m93 209 1 > > XX cord-284627-qvz63m93 210 1 T T NNP cord-284627-qvz63m93 210 2 _SP cord-284627-qvz63m93 211 1 0·0641 0·0641 CD cord-284627-qvz63m93 211 2 _SP cord-284627-qvz63m93 212 1 0·20 0·20 CD cord-284627-qvz63m93 212 2 _SP cord-284627-qvz63m93 213 1 1·14 1·14 CD cord-284627-qvz63m93 213 2 Common common JJ cord-284627-qvz63m93 213 3 _SP cord-284627-qvz63m93 213 4 G g NN cord-284627-qvz63m93 214 1 > > XX cord-284627-qvz63m93 215 1 A a DT cord-284627-qvz63m93 215 2 _SP cord-284627-qvz63m93 215 3 0·0592 0·0592 CD cord-284627-qvz63m93 215 4 _SP cord-284627-qvz63m93 216 1 0·025 0·025 CD cord-284627-qvz63m93 216 2 _SP cord-284627-qvz63m93 217 1 -0·86 -0·86 : cord-284627-qvz63m93 217 2 _SP cord-284627-qvz63m93 218 1 Very very RB cord-284627-qvz63m93 218 2 _SP cord-284627-qvz63m93 218 3 Rare rare JJ cord-284627-qvz63m93 218 4 _SP cord-284627-qvz63m93 219 1 13 13 CD cord-284627-qvz63m93 219 2 _SP cord-284627-qvz63m93 219 3 13225 13225 CD cord-284627-qvz63m93 219 4 _SP cord-284627-qvz63m93 219 5 C C NNP cord-284627-qvz63m93 219 6 _SP cord-284627-qvz63m93 220 1 G G NNP cord-284627-qvz63m93 220 2 _SP cord-284627-qvz63m93 221 1 0·923 0·923 CD cord-284627-qvz63m93 221 2 _SP cord-284627-qvz63m93 222 1 C C NNP cord-284627-qvz63m93 223 1 > > XX cord-284627-qvz63m93 224 1 G G NNP cord-284627-qvz63m93 224 2 _SP cord-284627-qvz63m93 224 3 0·0416 0·0416 CD cord-284627-qvz63m93 224 4 _SP cord-284627-qvz63m93 225 1 0·05 0·05 CD cord-284627-qvz63m93 225 2 _SP cord-284627-qvz63m93 226 1 0·18 0·18 CD cord-284627-qvz63m93 227 1 Common common JJ cord-284627-qvz63m93 227 2 _SP cord-284627-qvz63m93 228 1 14 14 CD cord-284627-qvz63m93 228 2 _SP cord-284627-qvz63m93 229 1 13226 13226 CD cord-284627-qvz63m93 229 2 _SP cord-284627-qvz63m93 230 1 T T NNP cord-284627-qvz63m93 230 2 _SP cord-284627-qvz63m93 231 1 C C NNP cord-284627-qvz63m93 231 2 _SP cord-284627-qvz63m93 232 1 0·923 0·923 CD cord-284627-qvz63m93 232 2 _SP cord-284627-qvz63m93 233 1 T T NNP cord-284627-qvz63m93 234 1 > > XX cord-284627-qvz63m93 235 1 C C NNP cord-284627-qvz63m93 235 2 _SP cord-284627-qvz63m93 236 1 0·0615 0·0615 NFP cord-284627-qvz63m93 236 2 _SP cord-284627-qvz63m93 237 1 0·175 0·175 CD cord-284627-qvz63m93 237 2 _SP cord-284627-qvz63m93 238 1 1·05 1·05 CD cord-284627-qvz63m93 239 1 Common common JJ cord-284627-qvz63m93 239 2 _SP cord-284627-qvz63m93 239 3 15 15 CD cord-284627-qvz63m93 239 4 _SP cord-284627-qvz63m93 240 1 14657 14657 CD cord-284627-qvz63m93 240 2 _SP cord-284627-qvz63m93 241 1 C C NNP cord-284627-qvz63m93 241 2 _SP cord-284627-qvz63m93 241 3 T T NNP cord-284627-qvz63m93 241 4 _SP cord-284627-qvz63m93 242 1 0·923 0·923 CD cord-284627-qvz63m93 242 2 _SP cord-284627-qvz63m93 243 1 C C NNP cord-284627-qvz63m93 244 1 > > XX cord-284627-qvz63m93 245 1 T T NNP cord-284627-qvz63m93 245 2 _SP cord-284627-qvz63m93 246 1 0·0615 0·0615 NFP cord-284627-qvz63m93 246 2 _SP cord-284627-qvz63m93 247 1 0·375 0·375 CD cord-284627-qvz63m93 247 2 _SP cord-284627-qvz63m93 248 1 1·81 1·81 CD cord-284627-qvz63m93 248 2 _SP cord-284627-qvz63m93 249 1 Very very RB cord-284627-qvz63m93 249 2 _SP cord-284627-qvz63m93 249 3 Common common JJ cord-284627-qvz63m93 249 4 _SP cord-284627-qvz63m93 250 1 16 16 CD cord-284627-qvz63m93 250 2 _SP cord-284627-qvz63m93 251 1 14805 14805 CD cord-284627-qvz63m93 251 2 _SP cord-284627-qvz63m93 252 1 C C NNP cord-284627-qvz63m93 252 2 _SP cord-284627-qvz63m93 253 1 T T NNP cord-284627-qvz63m93 253 2 _SP cord-284627-qvz63m93 253 3 0·846 0·846 CD cord-284627-qvz63m93 253 4 _SP cord-284627-qvz63m93 254 1 C C NNP cord-284627-qvz63m93 255 1 > > XX cord-284627-qvz63m93 256 1 T T NNP cord-284627-qvz63m93 256 2 _SP cord-284627-qvz63m93 257 1 0·0615 0·0615 NFP cord-284627-qvz63m93 257 2 _SP cord-284627-qvz63m93 258 1 0·375 0·375 CD cord-284627-qvz63m93 258 2 _SP cord-284627-qvz63m93 259 1 1·81 1·81 CD cord-284627-qvz63m93 259 2 _SP cord-284627-qvz63m93 260 1 Very very RB cord-284627-qvz63m93 260 2 _SP cord-284627-qvz63m93 260 3 Common common JJ cord-284627-qvz63m93 260 4 _SP cord-284627-qvz63m93 261 1 17 17 CD cord-284627-qvz63m93 261 2 _SP cord-284627-qvz63m93 262 1 15324 15324 CD cord-284627-qvz63m93 262 2 _SP cord-284627-qvz63m93 263 1 C C NNP cord-284627-qvz63m93 263 2 _SP cord-284627-qvz63m93 264 1 T T NNP cord-284627-qvz63m93 264 2 _SP cord-284627-qvz63m93 265 1 0·923 0·923 CD cord-284627-qvz63m93 265 2 _SP cord-284627-qvz63m93 266 1 C C NNP cord-284627-qvz63m93 267 1 > > XX cord-284627-qvz63m93 268 1 T T NNP cord-284627-qvz63m93 268 2 _SP cord-284627-qvz63m93 269 1 0·0615 0·0615 NFP cord-284627-qvz63m93 269 2 _SP cord-284627-qvz63m93 270 1 0·375 0·375 CD cord-284627-qvz63m93 270 2 _SP cord-284627-qvz63m93 271 1 1·81 1·81 CD cord-284627-qvz63m93 271 2 _SP cord-284627-qvz63m93 272 1 Very very RB cord-284627-qvz63m93 272 2 _SP cord-284627-qvz63m93 272 3 Common common JJ cord-284627-qvz63m93 272 4 _SP cord-284627-qvz63m93 273 1 18 18 CD cord-284627-qvz63m93 273 2 _SP cord-284627-qvz63m93 273 3 17247 17247 CD cord-284627-qvz63m93 273 4 _SP cord-284627-qvz63m93 274 1 C C NNP cord-284627-qvz63m93 274 2 _SP cord-284627-qvz63m93 274 3 T T NNP cord-284627-qvz63m93 274 4 _SP cord-284627-qvz63m93 275 1 0·923 0·923 CD cord-284627-qvz63m93 275 2 _SP cord-284627-qvz63m93 276 1 C C NNP cord-284627-qvz63m93 277 1 > > XX cord-284627-qvz63m93 278 1 T T NNP cord-284627-qvz63m93 278 2 _SP cord-284627-qvz63m93 279 1 0·0615 0·0615 NFP cord-284627-qvz63m93 279 2 _SP cord-284627-qvz63m93 280 1 0·375 0·375 CD cord-284627-qvz63m93 280 2 _SP cord-284627-qvz63m93 281 1 1·81 1·81 CD cord-284627-qvz63m93 281 2 _SP cord-284627-qvz63m93 282 1 Very very RB cord-284627-qvz63m93 282 2 _SP cord-284627-qvz63m93 282 3 Common Common NNP cord-284627-qvz63m93 282 4 _SP cord-284627-qvz63m93 282 5 19 19 CD cord-284627-qvz63m93 282 6 _SP cord-284627-qvz63m93 282 7 17373 17373 CD cord-284627-qvz63m93 282 8 _SP cord-284627-qvz63m93 282 9 C C NNP cord-284627-qvz63m93 282 10 _SP cord-284627-qvz63m93 283 1 T T NNP cord-284627-qvz63m93 283 2 _SP cord-284627-qvz63m93 284 1 0·923 0·923 CD cord-284627-qvz63m93 284 2 _SP cord-284627-qvz63m93 285 1 C C NNP cord-284627-qvz63m93 286 1 > > XX cord-284627-qvz63m93 287 1 T T NNP cord-284627-qvz63m93 287 2 _SP cord-284627-qvz63m93 288 1 0·0615 0·0615 NFP cord-284627-qvz63m93 288 2 _SP cord-284627-qvz63m93 289 1 0·375 0·375 CD cord-284627-qvz63m93 289 2 _SP cord-284627-qvz63m93 290 1 1·81 1·81 CD cord-284627-qvz63m93 290 2 _SP cord-284627-qvz63m93 291 1 Very very RB cord-284627-qvz63m93 291 2 _SP cord-284627-qvz63m93 291 3 Common common JJ cord-284627-qvz63m93 291 4 _SP cord-284627-qvz63m93 292 1 20 20 CD cord-284627-qvz63m93 292 2 _SP cord-284627-qvz63m93 293 1 17376 17376 CD cord-284627-qvz63m93 293 2 _SP cord-284627-qvz63m93 294 1 A a DT cord-284627-qvz63m93 294 2 _SP cord-284627-qvz63m93 295 1 G G NNP cord-284627-qvz63m93 295 2 _SP cord-284627-qvz63m93 296 1 0·923 0·923 CD cord-284627-qvz63m93 296 2 _SP cord-284627-qvz63m93 297 1 A a DT cord-284627-qvz63m93 298 1 > > XX cord-284627-qvz63m93 298 2 G G NNP cord-284627-qvz63m93 298 3 _SP cord-284627-qvz63m93 298 4 0·0592 0·0592 CD cord-284627-qvz63m93 298 5 _SP cord-284627-qvz63m93 299 1 0·05 0·05 CD cord-284627-qvz63m93 299 2 _SP cord-284627-qvz63m93 299 3 -0·16 -0·16 XX cord-284627-qvz63m93 299 4 _SP cord-284627-qvz63m93 300 1 Rare rare JJ cord-284627-qvz63m93 300 2 _SP cord-284627-qvz63m93 301 1 21 21 CD cord-284627-qvz63m93 301 2 _SP cord-284627-qvz63m93 302 1 19065 19065 CD cord-284627-qvz63m93 302 2 _SP cord-284627-qvz63m93 303 1 T T NNP cord-284627-qvz63m93 303 2 _SP cord-284627-qvz63m93 304 1 C C NNP cord-284627-qvz63m93 304 2 _SP cord-284627-qvz63m93 305 1 0·923 0·923 CD cord-284627-qvz63m93 305 2 _SP cord-284627-qvz63m93 306 1 T T NNP cord-284627-qvz63m93 307 1 > > XX cord-284627-qvz63m93 308 1 C C NNP cord-284627-qvz63m93 308 2 _SP cord-284627-qvz63m93 309 1 0·0615 0·0615 NFP cord-284627-qvz63m93 309 2 _SP cord-284627-qvz63m93 310 1 0·175 0·175 CD cord-284627-qvz63m93 310 2 _SP cord-284627-qvz63m93 311 1 1·05 1·05 CD cord-284627-qvz63m93 312 1 Common common JJ cord-284627-qvz63m93 312 2 _SP cord-284627-qvz63m93 312 3 22 22 CD cord-284627-qvz63m93 312 4 _SP cord-284627-qvz63m93 313 1 21707 21707 CD cord-284627-qvz63m93 313 2 _SP cord-284627-qvz63m93 314 1 C C NNP cord-284627-qvz63m93 314 2 _SP cord-284627-qvz63m93 315 1 T T NNP cord-284627-qvz63m93 315 2 _SP cord-284627-qvz63m93 315 3 0·846 0·846 CD cord-284627-qvz63m93 315 4 _SP cord-284627-qvz63m93 316 1 C C NNP cord-284627-qvz63m93 317 1 > > XX cord-284627-qvz63m93 318 1 T T NNP cord-284627-qvz63m93 318 2 _SP cord-284627-qvz63m93 319 1 0·0615 0·0615 NFP cord-284627-qvz63m93 319 2 _SP cord-284627-qvz63m93 320 1 0·375 0·375 CD cord-284627-qvz63m93 320 2 _SP cord-284627-qvz63m93 321 1 1·81 1·81 CD cord-284627-qvz63m93 321 2 _SP cord-284627-qvz63m93 322 1 Very very RB cord-284627-qvz63m93 322 2 _SP cord-284627-qvz63m93 323 1 Common common JJ cord-284627-qvz63m93 323 2 _SP cord-284627-qvz63m93 324 1 23 23 CD cord-284627-qvz63m93 324 2 _SP cord-284627-qvz63m93 325 1 21964 21964 CD cord-284627-qvz63m93 325 2 - - SYM cord-284627-qvz63m93 325 3 66 66 CD cord-284627-qvz63m93 325 4 _SP cord-284627-qvz63m93 326 1 TTA TTA NNP cord-284627-qvz63m93 326 2 _SP cord-284627-qvz63m93 326 3 ---0·923 ---0·923 NNP cord-284627-qvz63m93 326 4 _SP cord-284627-qvz63m93 327 1 NA NA NNP cord-284627-qvz63m93 327 2 _SP cord-284627-qvz63m93 328 1 NA NA NNP cord-284627-qvz63m93 328 2 _SP cord-284627-qvz63m93 329 1 NA NA NNP cord-284627-qvz63m93 329 2 _SP cord-284627-qvz63m93 330 1 NA NA NNP cord-284627-qvz63m93 330 2 _SP cord-284627-qvz63m93 331 1 NA NA NNP cord-284627-qvz63m93 331 2 _SP cord-284627-qvz63m93 331 3 24 24 CD cord-284627-qvz63m93 331 4 _SP cord-284627-qvz63m93 331 5 22303 22303 CD cord-284627-qvz63m93 331 6 _SP cord-284627-qvz63m93 332 1 T T NNP cord-284627-qvz63m93 332 2 _SP cord-284627-qvz63m93 333 1 G G NNP cord-284627-qvz63m93 333 2 _SP cord-284627-qvz63m93 334 1 0·923 0·923 CD cord-284627-qvz63m93 334 2 _SP cord-284627-qvz63m93 335 1 T T NNP cord-284627-qvz63m93 336 1 > > XX cord-284627-qvz63m93 337 1 G G NNP cord-284627-qvz63m93 337 2 _SP cord-284627-qvz63m93 337 3 0·0641 0·0641 CD cord-284627-qvz63m93 337 4 _SP cord-284627-qvz63m93 338 1 0·05 0·05 CD cord-284627-qvz63m93 338 2 _SP cord-284627-qvz63m93 339 1 -0·24 -0·24 : cord-284627-qvz63m93 339 2 _SP cord-284627-qvz63m93 340 1 Rare rare JJ cord-284627-qvz63m93 340 2 _SP cord-284627-qvz63m93 341 1 25 25 CD cord-284627-qvz63m93 341 2 _SP cord-284627-qvz63m93 341 3 22785 22785 CD cord-284627-qvz63m93 341 4 _SP cord-284627-qvz63m93 342 1 G G NNP cord-284627-qvz63m93 342 2 _SP cord-284627-qvz63m93 343 1 T T NNP cord-284627-qvz63m93 343 2 _SP cord-284627-qvz63m93 344 1 0·923 0·923 CD cord-284627-qvz63m93 344 2 _SP cord-284627-qvz63m93 345 1 G g NN cord-284627-qvz63m93 346 1 > > XX cord-284627-qvz63m93 347 1 T T NNP cord-284627-qvz63m93 347 2 _SP cord-284627-qvz63m93 348 1 0·0641 0·0641 CD cord-284627-qvz63m93 348 2 _SP cord-284627-qvz63m93 349 1 0·20 0·20 CD cord-284627-qvz63m93 349 2 _SP cord-284627-qvz63m93 349 3 1·14 1·14 CD cord-284627-qvz63m93 350 1 Common common JJ cord-284627-qvz63m93 350 2 _SP cord-284627-qvz63m93 351 1 26 26 CD cord-284627-qvz63m93 351 2 _SP cord-284627-qvz63m93 352 1 23952 23952 CD cord-284627-qvz63m93 352 2 _SP cord-284627-qvz63m93 353 1 T T NNP cord-284627-qvz63m93 353 2 _SP cord-284627-qvz63m93 354 1 G G NNP cord-284627-qvz63m93 354 2 _SP cord-284627-qvz63m93 355 1 0·923 0·923 CD cord-284627-qvz63m93 355 2 _SP cord-284627-qvz63m93 356 1 T T NNP cord-284627-qvz63m93 357 1 > > XX cord-284627-qvz63m93 358 1 G G NNP cord-284627-qvz63m93 358 2 _SP cord-284627-qvz63m93 358 3 0·0641 0·0641 CD cord-284627-qvz63m93 358 4 _SP cord-284627-qvz63m93 359 1 NA NA NNP cord-284627-qvz63m93 359 2 _SP cord-284627-qvz63m93 360 1 NA NA NNP cord-284627-qvz63m93 360 2 _SP cord-284627-qvz63m93 361 1 NA NA NNP cord-284627-qvz63m93 361 2 _SP cord-284627-qvz63m93 362 1 27 27 CD cord-284627-qvz63m93 362 2 _SP cord-284627-qvz63m93 363 1 24034 24034 CD cord-284627-qvz63m93 363 2 _SP cord-284627-qvz63m93 364 1 C C NNP cord-284627-qvz63m93 364 2 _SP cord-284627-qvz63m93 365 1 T T NNP cord-284627-qvz63m93 365 2 _SP cord-284627-qvz63m93 366 1 0·923 0·923 CD cord-284627-qvz63m93 366 2 _SP cord-284627-qvz63m93 367 1 C C NNP cord-284627-qvz63m93 368 1 > > XX cord-284627-qvz63m93 369 1 T T NNP cord-284627-qvz63m93 369 2 _SP cord-284627-qvz63m93 370 1 0·0615 0·0615 NFP cord-284627-qvz63m93 370 2 _SP cord-284627-qvz63m93 371 1 0·375 0·375 CD cord-284627-qvz63m93 371 2 T t NN cord-284627-qvz63m93 371 3 > > XX cord-284627-qvz63m93 372 1 C C NNP cord-284627-qvz63m93 372 2 _SP cord-284627-qvz63m93 373 1 A a DT cord-284627-qvz63m93 374 1 > > XX cord-284627-qvz63m93 374 2 G g NN cord-284627-qvz63m93 374 3 _SP cord-284627-qvz63m93 374 4 T t NN cord-284627-qvz63m93 375 1 > > XX cord-284627-qvz63m93 376 1 G G NNP cord-284627-qvz63m93 376 2 _SP cord-284627-qvz63m93 377 1 G g NN cord-284627-qvz63m93 378 1 > > XX cord-284627-qvz63m93 379 1 T T NNP cord-284627-qvz63m93 379 2 _SP cord-284627-qvz63m93 379 3 GGT ggt NN cord-284627-qvz63m93 380 1 > > XX cord-284627-qvz63m93 381 1 AGT AGT NNP cord-284627-qvz63m93 381 2 _SP cord-284627-qvz63m93 381 3 AGA AGA NNP cord-284627-qvz63m93 382 1 > > XX cord-284627-qvz63m93 383 1 AGG AGG NNP cord-284627-qvz63m93 383 2 _SP cord-284627-qvz63m93 383 3 TCC tcc NN cord-284627-qvz63m93 384 1 > > XX cord-284627-qvz63m93 385 1 TCG TCG NNP cord-284627-qvz63m93 385 2 _SP cord-284627-qvz63m93 385 3 TTT TTT NNP cord-284627-qvz63m93 386 1 > > XX cord-284627-qvz63m93 387 1 CTT CTT NNP cord-284627-qvz63m93 387 2 _SP cord-284627-qvz63m93 387 3 ACA ACA NNP cord-284627-qvz63m93 388 1 > > XX cord-284627-qvz63m93 389 1 ACG ACG NNP cord-284627-qvz63m93 389 2 _SP cord-284627-qvz63m93 389 3 TTT TTT NNP cord-284627-qvz63m93 390 1 > > XX cord-284627-qvz63m93 391 1 TGT TGT NNP cord-284627-qvz63m93 391 2 _SP cord-284627-qvz63m93 392 1 GGT GGT NNP cord-284627-qvz63m93 392 2 > > XX cord-284627-qvz63m93 393 1 GTT GTT NNP cord-284627-qvz63m93 393 2 _SP cord-284627-qvz63m93 394 1 G818S G818S NNP cord-284627-qvz63m93 394 2 _SP cord-284627-qvz63m93 395 1 R3003R R3003R NNP cord-284627-qvz63m93 395 2 _SP cord-284627-qvz63m93 396 1 S4320S S4320S NNP cord-284627-qvz63m93 396 2 _SP cord-284627-qvz63m93 397 1 F4321L F4321L NNP cord-284627-qvz63m93 397 2 _SP cord-284627-qvz63m93 398 1 T1203 T1203 NNP cord-284627-qvz63m93 398 2 T T NNP cord-284627-qvz63m93 398 3 _SP cord-284627-qvz63m93 399 1 F806C F806C NNP cord-284627-qvz63m93 399 2 _SP cord-284627-qvz63m93 400 1 G251V G251V NNP cord-284627-qvz63m93 400 2 _SP cord-284627-qvz63m93 401 1 NS NS NNP cord-284627-qvz63m93 401 2 _SP cord-284627-qvz63m93 402 1 S S NNP cord-284627-qvz63m93 402 2 _SP cord-284627-qvz63m93 403 1 S S NNP cord-284627-qvz63m93 403 2 _SP cord-284627-qvz63m93 404 1 NS NS NNP cord-284627-qvz63m93 404 2 _SP cord-284627-qvz63m93 405 1 S S NNP cord-284627-qvz63m93 405 2 _SP cord-284627-qvz63m93 406 1 NS NS NNP cord-284627-qvz63m93 406 2 _SP cord-284627-qvz63m93 407 1 NS NS NNP cord-284627-qvz63m93 407 2 _SP cord-284627-qvz63m93 408 1 9·20 9·20 LS cord-284627-qvz63m93 408 2 _SP cord-284627-qvz63m93 409 1 MT233523 MT233523 NNP cord-284627-qvz63m93 409 2 _SP cord-284627-qvz63m93 410 1 Spain Spain NNP cord-284627-qvz63m93 410 2 _SP cord-284627-qvz63m93 411 1 7 7 LS cord-284627-qvz63m93 411 2 _SP cord-284627-qvz63m93 411 3 8782 8782 CD cord-284627-qvz63m93 411 4 _SP cord-284627-qvz63m93 412 1 9477 9477 CD cord-284627-qvz63m93 412 2 _SP cord-284627-qvz63m93 413 1 14805 14805 CD cord-284627-qvz63m93 413 2 _SP cord-284627-qvz63m93 414 1 25979 25979 CD cord-284627-qvz63m93 414 2 _SP cord-284627-qvz63m93 415 1 28144 28144 CD cord-284627-qvz63m93 415 2 _SP cord-284627-qvz63m93 416 1 28657 28657 CD cord-284627-qvz63m93 416 2 _SP cord-284627-qvz63m93 417 1 28863 28863 CD cord-284627-qvz63m93 417 2 _SP cord-284627-qvz63m93 418 1 C C NNP cord-284627-qvz63m93 419 1 > > XX cord-284627-qvz63m93 420 1 T T NNP cord-284627-qvz63m93 420 2 _SP cord-284627-qvz63m93 420 3 T T NNP cord-284627-qvz63m93 421 1 > > XX cord-284627-qvz63m93 422 1 A a DT cord-284627-qvz63m93 422 2 _SP cord-284627-qvz63m93 422 3 C c NN cord-284627-qvz63m93 423 1 > > XX cord-284627-qvz63m93 424 1 T T NNP cord-284627-qvz63m93 424 2 _SP cord-284627-qvz63m93 425 1 G g NN cord-284627-qvz63m93 426 1 > > XX cord-284627-qvz63m93 427 1 T T NNP cord-284627-qvz63m93 427 2 _SP cord-284627-qvz63m93 427 3 T T NNP cord-284627-qvz63m93 428 1 > > XX cord-284627-qvz63m93 429 1 C C NNP cord-284627-qvz63m93 429 2 _SP cord-284627-qvz63m93 430 1 C C NNP cord-284627-qvz63m93 431 1 > > XX cord-284627-qvz63m93 432 1 T T NNP cord-284627-qvz63m93 432 2 _SP cord-284627-qvz63m93 433 1 C C NNP cord-284627-qvz63m93 434 1 > > XX cord-284627-qvz63m93 435 1 T T NNP cord-284627-qvz63m93 435 2 _SP cord-284627-qvz63m93 435 3 AGC AGC NNP cord-284627-qvz63m93 436 1 > > XX cord-284627-qvz63m93 437 1 AGT AGT NNP cord-284627-qvz63m93 437 2 _SP cord-284627-qvz63m93 437 3 TTT TTT NNP cord-284627-qvz63m93 438 1 > > XX cord-284627-qvz63m93 439 1 TAT TAT NNP cord-284627-qvz63m93 439 2 _SP cord-284627-qvz63m93 440 1 TAC TAC NNP cord-284627-qvz63m93 441 1 > > XX cord-284627-qvz63m93 442 1 TAT TAT NNP cord-284627-qvz63m93 442 2 _SP cord-284627-qvz63m93 443 1 GGA GGA NNP cord-284627-qvz63m93 444 1 > > XX cord-284627-qvz63m93 445 1 GTA GTA NNP cord-284627-qvz63m93 445 2 _SP cord-284627-qvz63m93 445 3 TTT TTT NNP cord-284627-qvz63m93 446 1 > > XX cord-284627-qvz63m93 447 1 TTC TTC NNP cord-284627-qvz63m93 447 2 _SP cord-284627-qvz63m93 447 3 GAC GAC NNP cord-284627-qvz63m93 448 1 > > XX cord-284627-qvz63m93 449 1 GAT GAT NNP cord-284627-qvz63m93 449 2 _SP cord-284627-qvz63m93 449 3 TCA TCA NNP cord-284627-qvz63m93 450 1 > > XX cord-284627-qvz63m93 451 1 TTA TTA NNP cord-284627-qvz63m93 451 2 _SP cord-284627-qvz63m93 452 1 S2839S S2839S NNP cord-284627-qvz63m93 452 2 _SP cord-284627-qvz63m93 453 1 F3071Y F3071Y NNP cord-284627-qvz63m93 453 2 _SP cord-284627-qvz63m93 454 1 Y346Y Y346Y NNP cord-284627-qvz63m93 454 2 _SP cord-284627-qvz63m93 455 1 G196V G196V NNP cord-284627-qvz63m93 455 2 _SP cord-284627-qvz63m93 456 1 F87F F87F NNP cord-284627-qvz63m93 456 2 _SP cord-284627-qvz63m93 457 1 D128D D128D NNP cord-284627-qvz63m93 457 2 _SP cord-284627-qvz63m93 458 1 S197L S197L NNP cord-284627-qvz63m93 458 2 _SP cord-284627-qvz63m93 459 1 S S NNP cord-284627-qvz63m93 459 2 _SP cord-284627-qvz63m93 460 1 NS NS NNP cord-284627-qvz63m93 460 2 _SP cord-284627-qvz63m93 461 1 S S NNP cord-284627-qvz63m93 461 2 _SP cord-284627-qvz63m93 462 1 On on IN cord-284627-qvz63m93 462 2 the the DT cord-284627-qvz63m93 462 3 origin origin NN cord-284627-qvz63m93 462 4 and and CC cord-284627-qvz63m93 462 5 continuing continue VBG cord-284627-qvz63m93 462 6 evolution evolution NN cord-284627-qvz63m93 462 7 of of IN cord-284627-qvz63m93 462 8 SARS SARS NNP cord-284627-qvz63m93 462 9 - - HYPH cord-284627-qvz63m93 462 10 CoV-2 CoV-2 NNP cord-284627-qvz63m93 462 11 Genetic genetic JJ cord-284627-qvz63m93 462 12 diversity diversity NN cord-284627-qvz63m93 462 13 and and CC cord-284627-qvz63m93 462 14 evolution evolution NN cord-284627-qvz63m93 462 15 of of IN cord-284627-qvz63m93 462 16 SARS SARS NNP cord-284627-qvz63m93 462 17 - - HYPH cord-284627-qvz63m93 462 18 CoV-2 CoV-2 NNP cord-284627-qvz63m93 462 19 Mechanisms Mechanisms NNPS cord-284627-qvz63m93 462 20 of of IN cord-284627-qvz63m93 462 21 viral viral JJ cord-284627-qvz63m93 462 22 mutation mutation NN cord-284627-qvz63m93 463 1 The the DT cord-284627-qvz63m93 463 2 establishment establishment NN cord-284627-qvz63m93 463 3 of of IN cord-284627-qvz63m93 463 4 reference reference NN cord-284627-qvz63m93 463 5 sequence sequence NN cord-284627-qvz63m93 463 6 for for IN cord-284627-qvz63m93 463 7 SARS SARS NNP cord-284627-qvz63m93 463 8 CoV CoV NNP cord-284627-qvz63m93 463 9 2 2 CD cord-284627-qvz63m93 463 10 and and CC cord-284627-qvz63m93 463 11 variation variation NN cord-284627-qvz63m93 463 12 analysis analysis NN cord-284627-qvz63m93 463 13 SIFT sift VB cord-284627-qvz63m93 463 14 : : : cord-284627-qvz63m93 464 1 Predicting predict VBG cord-284627-qvz63m93 464 2 amino amino NN cord-284627-qvz63m93 464 3 acid acid NN cord-284627-qvz63m93 464 4 changes change NNS cord-284627-qvz63m93 464 5 that that WDT cord-284627-qvz63m93 464 6 affect affect VBP cord-284627-qvz63m93 464 7 protein protein NN cord-284627-qvz63m93 464 8 function function NN cord-284627-qvz63m93 464 9 HIV HIV NNP cord-284627-qvz63m93 464 10 Signature Signature NNP cord-284627-qvz63m93 464 11 and and CC cord-284627-qvz63m93 464 12 Sequence Sequence NNP cord-284627-qvz63m93 464 13 Variation Variation NNP cord-284627-qvz63m93 464 14 Analysis Analysis NNP cord-284627-qvz63m93 465 1 Predicting predict VBG cord-284627-qvz63m93 465 2 functional functional JJ cord-284627-qvz63m93 465 3 effect effect NN cord-284627-qvz63m93 465 4 of of IN cord-284627-qvz63m93 465 5 human human JJ cord-284627-qvz63m93 465 6 missense missense NN cord-284627-qvz63m93 465 7 mutations mutation NNS cord-284627-qvz63m93 465 8 using use VBG cord-284627-qvz63m93 465 9 PolyPhen-2 PolyPhen-2 NNPS cord-284627-qvz63m93 465 10 Collective collective JJ cord-284627-qvz63m93 465 11 judgment judgment NN cord-284627-qvz63m93 465 12 predicts predict VBZ cord-284627-qvz63m93 465 13 disease disease NN cord-284627-qvz63m93 465 14 - - HYPH cord-284627-qvz63m93 465 15 associated associate VBN cord-284627-qvz63m93 465 16 single single JJ cord-284627-qvz63m93 465 17 nucleotide nucleotide JJ cord-284627-qvz63m93 465 18 variants variant NNS cord-284627-qvz63m93 465 19 mutations mutation NNS cord-284627-qvz63m93 465 20 in in IN cord-284627-qvz63m93 465 21 proteins protein NNS cord-284627-qvz63m93 466 1 Nonstructural nonstructural JJ cord-284627-qvz63m93 466 2 proteins protein NNS cord-284627-qvz63m93 466 3 NS7b NS7b NNP cord-284627-qvz63m93 466 4 and and CC cord-284627-qvz63m93 466 5 NS8 NS8 NNP cord-284627-qvz63m93 466 6 are be VBP cord-284627-qvz63m93 466 7 likely likely JJ cord-284627-qvz63m93 466 8 to to TO cord-284627-qvz63m93 466 9 be be VB cord-284627-qvz63m93 466 10 phylogenetically phylogenetically RB cord-284627-qvz63m93 466 11 associated associate VBN cord-284627-qvz63m93 466 12 with with IN cord-284627-qvz63m93 466 13 evolution evolution NN cord-284627-qvz63m93 466 14 of of IN cord-284627-qvz63m93 466 15 2019-nCoV 2019-ncov CD cord-284627-qvz63m93 467 1 The the DT cord-284627-qvz63m93 467 2 2019-new 2019-new CD cord-284627-qvz63m93 467 3 coronavirus coronavirus NN cord-284627-qvz63m93 467 4 epidemic epidemic NN cord-284627-qvz63m93 467 5 : : : cord-284627-qvz63m93 467 6 Evidence evidence NN cord-284627-qvz63m93 467 7 for for IN cord-284627-qvz63m93 467 8 virus virus NN cord-284627-qvz63m93 467 9 evolution evolution NN cord-284627-qvz63m93 467 10 Genetic genetic JJ cord-284627-qvz63m93 467 11 variation variation NN cord-284627-qvz63m93 467 12 : : : cord-284627-qvz63m93 468 1 Synonymous synonymous JJ cord-284627-qvz63m93 468 2 mutations mutation NNS cord-284627-qvz63m93 468 3 break break VBP cord-284627-qvz63m93 468 4 their -PRON- PRP$ cord-284627-qvz63m93 468 5 silence silence NN cord-284627-qvz63m93 469 1 The the DT cord-284627-qvz63m93 469 2 authors author NNS cord-284627-qvz63m93 469 3 acknowledge acknowledge VBP cord-284627-qvz63m93 469 4 UGC UGC NNP cord-284627-qvz63m93 469 5 - - HYPH cord-284627-qvz63m93 469 6 DAE DAE NNP cord-284627-qvz63m93 469 7 CSR CSR NNP cord-284627-qvz63m93 469 8 for for IN cord-284627-qvz63m93 469 9 providing provide VBG cord-284627-qvz63m93 469 10 fellowship fellowship NN cord-284627-qvz63m93 469 11 to to IN cord-284627-qvz63m93 469 12 Shuvam Shuvam NNP cord-284627-qvz63m93 469 13 Banerjee Banerjee NNP cord-284627-qvz63m93 469 14 . . .