id	sid	tid	token	lemma	pos
cord-260054-iihgc5nr	1	1	key	key	NN
cord-260054-iihgc5nr	1	2	:	:	:
cord-260054-iihgc5nr	1	3	cord-260054-iihgc5nr	cord-260054-iihgc5nr	.
cord-260054-iihgc5nr	2	1	authors	author	NNS
cord-260054-iihgc5nr	2	2	:	:	:
cord-260054-iihgc5nr	2	3	Cavallo	Cavallo	NNP
cord-260054-iihgc5nr	2	4	,	,	,
cord-260054-iihgc5nr	2	5	Luigi	Luigi	NNP
cord-260054-iihgc5nr	2	6	;	;	:
cord-260054-iihgc5nr	2	7	Oliva	Oliva	NNP
cord-260054-iihgc5nr	2	8	,	,	,
cord-260054-iihgc5nr	2	9	Romina	Romina	NNP
cord-260054-iihgc5nr	2	10	title	title	NN
cord-260054-iihgc5nr	2	11	:	:	:
cord-260054-iihgc5nr	2	12	D936Y	D936Y	NNP
cord-260054-iihgc5nr	2	13	and	and	CC
cord-260054-iihgc5nr	2	14	Other	Other	NNP
cord-260054-iihgc5nr	2	15	Mutations	Mutations	NNPS
cord-260054-iihgc5nr	2	16	in	in	IN
cord-260054-iihgc5nr	2	17	the	the	DT
cord-260054-iihgc5nr	2	18	Fusion	Fusion	NNP
cord-260054-iihgc5nr	2	19	Core	Core	NNP
cord-260054-iihgc5nr	2	20	of	of	IN
cord-260054-iihgc5nr	2	21	the	the	DT
cord-260054-iihgc5nr	2	22	SARS	SARS	NNP
cord-260054-iihgc5nr	2	23	-	-	HYPH
cord-260054-iihgc5nr	2	24	Cov-2	Cov-2	NNP
cord-260054-iihgc5nr	2	25	Spike	Spike	NNP
cord-260054-iihgc5nr	2	26	Protein	Protein	NNP
cord-260054-iihgc5nr	2	27	Heptad	Heptad	NNP
cord-260054-iihgc5nr	2	28	Repeat	repeat	NN
cord-260054-iihgc5nr	2	29	1	1	CD
cord-260054-iihgc5nr	2	30	Undermine	undermine	VBP
cord-260054-iihgc5nr	2	31	the	the	DT
cord-260054-iihgc5nr	2	32	Post	Post	NNP
cord-260054-iihgc5nr	2	33	-	-	NNP
cord-260054-iihgc5nr	2	34	Fusion	Fusion	NNP
cord-260054-iihgc5nr	2	35	Assembly	Assembly	NNP
cord-260054-iihgc5nr	2	36	date	date	NN
cord-260054-iihgc5nr	3	1	:	:	:
cord-260054-iihgc5nr	3	2	2020	2020	CD
cord-260054-iihgc5nr	3	3	-	-	HYPH
cord-260054-iihgc5nr	3	4	06	06	CD
cord-260054-iihgc5nr	3	5	-	-	HYPH
cord-260054-iihgc5nr	3	6	08	08	CD
cord-260054-iihgc5nr	3	7	journal	journal	NN
cord-260054-iihgc5nr	3	8	:	:	:
cord-260054-iihgc5nr	4	1	bioRxiv	biorxiv	IN
cord-260054-iihgc5nr	4	2	DOI	DOI	NNP
cord-260054-iihgc5nr	4	3	:	:	:
cord-260054-iihgc5nr	5	1	10.1101/2020.06.08.140152	10.1101/2020.06.08.140152	CD
cord-260054-iihgc5nr	5	2	sha	sha	NNP
cord-260054-iihgc5nr	5	3	:	:	:
cord-260054-iihgc5nr	6	1	7bec72c240a061d6182d0c823d19efbae5014583	7bec72c240a061d6182d0c823d19efbae5014583	NNP
cord-260054-iihgc5nr	6	2	doc_id	doc_id	CD
cord-260054-iihgc5nr	6	3	:	:	:
cord-260054-iihgc5nr	6	4	260054	260054	CD
cord-260054-iihgc5nr	6	5	cord_uid	cord_uid	NNS
cord-260054-iihgc5nr	6	6	:	:	:
cord-260054-iihgc5nr	7	1	iihgc5nr	iihgc5nr	NNP
cord-260054-iihgc5nr	8	1	The	the	DT
cord-260054-iihgc5nr	8	2	iconic	iconic	JJ
cord-260054-iihgc5nr	8	3	“	"	``
cord-260054-iihgc5nr	8	4	red	red	JJ
cord-260054-iihgc5nr	8	5	crown	crown	NN
cord-260054-iihgc5nr	8	6	”	"	''
cord-260054-iihgc5nr	8	7	of	of	IN
cord-260054-iihgc5nr	8	8	the	the	DT
cord-260054-iihgc5nr	8	9	severe	severe	JJ
cord-260054-iihgc5nr	8	10	acute	acute	JJ
cord-260054-iihgc5nr	8	11	respiratory	respiratory	JJ
cord-260054-iihgc5nr	8	12	syndrome	syndrome	NN
cord-260054-iihgc5nr	8	13	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	8	14	2	2	CD
cord-260054-iihgc5nr	9	1	(	(	-LRB-
cord-260054-iihgc5nr	9	2	SARS	SARS	NNP
cord-260054-iihgc5nr	9	3	-	-	HYPH
cord-260054-iihgc5nr	9	4	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	9	5	)	)	-RRB-
cord-260054-iihgc5nr	9	6	is	be	VBZ
cord-260054-iihgc5nr	9	7	made	make	VBN
cord-260054-iihgc5nr	9	8	of	of	IN
cord-260054-iihgc5nr	9	9	its	-PRON-	PRP$
cord-260054-iihgc5nr	9	10	spike	spike	NN
cord-260054-iihgc5nr	9	11	(	(	-LRB-
cord-260054-iihgc5nr	9	12	S	s	NN
cord-260054-iihgc5nr	9	13	)	)	-RRB-
cord-260054-iihgc5nr	9	14	glycoprotein	glycoprotein	NN
cord-260054-iihgc5nr	9	15	.	.	.
cord-260054-iihgc5nr	10	1	The	the	DT
cord-260054-iihgc5nr	10	2	S	S	NNP
cord-260054-iihgc5nr	10	3	protein	protein	NN
cord-260054-iihgc5nr	10	4	is	be	VBZ
cord-260054-iihgc5nr	10	5	the	the	DT
cord-260054-iihgc5nr	10	6	Trojan	Trojan	NNP
cord-260054-iihgc5nr	10	7	horse	horse	NN
cord-260054-iihgc5nr	10	8	of	of	IN
cord-260054-iihgc5nr	10	9	coronaviruses	coronaviruse	NNS
cord-260054-iihgc5nr	10	10	,	,	,
cord-260054-iihgc5nr	10	11	mediating	mediate	VBG
cord-260054-iihgc5nr	10	12	their	-PRON-	PRP$
cord-260054-iihgc5nr	10	13	entry	entry	NN
cord-260054-iihgc5nr	10	14	into	into	IN
cord-260054-iihgc5nr	10	15	the	the	DT
cord-260054-iihgc5nr	10	16	host	host	NN
cord-260054-iihgc5nr	10	17	cells	cell	NNS
cord-260054-iihgc5nr	10	18	.	.	.
cord-260054-iihgc5nr	11	1	While	while	IN
cord-260054-iihgc5nr	11	2	SARS	SARS	NNP
cord-260054-iihgc5nr	11	3	-	-	HYPH
cord-260054-iihgc5nr	11	4	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	11	5	was	be	VBD
cord-260054-iihgc5nr	11	6	becoming	become	VBG
cord-260054-iihgc5nr	11	7	a	a	DT
cord-260054-iihgc5nr	11	8	global	global	JJ
cord-260054-iihgc5nr	11	9	threat	threat	NN
cord-260054-iihgc5nr	11	10	,	,	,
cord-260054-iihgc5nr	11	11	scientists	scientist	NNS
cord-260054-iihgc5nr	11	12	have	have	VBP
cord-260054-iihgc5nr	11	13	been	be	VBN
cord-260054-iihgc5nr	11	14	accumulating	accumulate	VBG
cord-260054-iihgc5nr	11	15	data	datum	NNS
cord-260054-iihgc5nr	11	16	on	on	IN
cord-260054-iihgc5nr	11	17	the	the	DT
cord-260054-iihgc5nr	11	18	virus	virus	NN
cord-260054-iihgc5nr	11	19	at	at	IN
cord-260054-iihgc5nr	11	20	an	an	DT
cord-260054-iihgc5nr	11	21	impressive	impressive	JJ
cord-260054-iihgc5nr	11	22	pace	pace	NN
cord-260054-iihgc5nr	11	23	,	,	,
cord-260054-iihgc5nr	11	24	both	both	CC
cord-260054-iihgc5nr	11	25	in	in	IN
cord-260054-iihgc5nr	11	26	terms	term	NNS
cord-260054-iihgc5nr	11	27	of	of	IN
cord-260054-iihgc5nr	11	28	genomic	genomic	JJ
cord-260054-iihgc5nr	11	29	sequences	sequence	NNS
cord-260054-iihgc5nr	11	30	and	and	CC
cord-260054-iihgc5nr	11	31	of	of	IN
cord-260054-iihgc5nr	11	32	three	three	CD
cord-260054-iihgc5nr	11	33	-	-	HYPH
cord-260054-iihgc5nr	11	34	dimensional	dimensional	JJ
cord-260054-iihgc5nr	11	35	structures	structure	NNS
cord-260054-iihgc5nr	11	36	.	.	.
cord-260054-iihgc5nr	12	1	On	on	IN
cord-260054-iihgc5nr	12	2	April	April	NNP
cord-260054-iihgc5nr	12	3	21st	21st	NN
cord-260054-iihgc5nr	12	4	,	,	,
cord-260054-iihgc5nr	12	5	the	the	DT
cord-260054-iihgc5nr	12	6	GISAID	GISAID	NNP
cord-260054-iihgc5nr	12	7	resource	resource	NN
cord-260054-iihgc5nr	12	8	had	have	VBD
cord-260054-iihgc5nr	12	9	collected	collect	VBN
cord-260054-iihgc5nr	12	10	10,823	10,823	CD
cord-260054-iihgc5nr	12	11	SARS	SARS	NNP
cord-260054-iihgc5nr	12	12	-	-	HYPH
cord-260054-iihgc5nr	12	13	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	12	14	genomic	genomic	JJ
cord-260054-iihgc5nr	12	15	sequences	sequence	NNS
cord-260054-iihgc5nr	12	16	.	.	.
cord-260054-iihgc5nr	13	1	We	-PRON-	PRP
cord-260054-iihgc5nr	13	2	extracted	extract	VBD
cord-260054-iihgc5nr	13	3	from	from	IN
cord-260054-iihgc5nr	13	4	them	-PRON-	PRP
cord-260054-iihgc5nr	13	5	all	all	PDT
cord-260054-iihgc5nr	13	6	the	the	DT
cord-260054-iihgc5nr	13	7	complete	complete	JJ
cord-260054-iihgc5nr	13	8	S	S	NNP
cord-260054-iihgc5nr	13	9	protein	protein	NN
cord-260054-iihgc5nr	13	10	sequences	sequence	NNS
cord-260054-iihgc5nr	13	11	and	and	CC
cord-260054-iihgc5nr	13	12	identified	identify	VBN
cord-260054-iihgc5nr	13	13	point	point	NN
cord-260054-iihgc5nr	13	14	mutations	mutation	NNS
cord-260054-iihgc5nr	13	15	thereof	thereof	RB
cord-260054-iihgc5nr	13	16	.	.	.
cord-260054-iihgc5nr	14	1	Six	six	CD
cord-260054-iihgc5nr	14	2	mutations	mutation	NNS
cord-260054-iihgc5nr	14	3	were	be	VBD
cord-260054-iihgc5nr	14	4	located	locate	VBN
cord-260054-iihgc5nr	14	5	on	on	IN
cord-260054-iihgc5nr	14	6	a	a	DT
cord-260054-iihgc5nr	14	7	14-residue	14-residue	CD
cord-260054-iihgc5nr	14	8	segment	segment	NN
cord-260054-iihgc5nr	14	9	(	(	-LRB-
cord-260054-iihgc5nr	14	10	929	929	CD
cord-260054-iihgc5nr	14	11	-	-	SYM
cord-260054-iihgc5nr	14	12	943	943	CD
cord-260054-iihgc5nr	14	13	)	)	-RRB-
cord-260054-iihgc5nr	14	14	in	in	IN
cord-260054-iihgc5nr	14	15	the	the	DT
cord-260054-iihgc5nr	14	16	“	"	``
cord-260054-iihgc5nr	14	17	fusion	fusion	NN
cord-260054-iihgc5nr	14	18	core	core	NN
cord-260054-iihgc5nr	14	19	”	"	''
cord-260054-iihgc5nr	14	20	of	of	IN
cord-260054-iihgc5nr	14	21	the	the	DT
cord-260054-iihgc5nr	14	22	heptad	heptad	NN
cord-260054-iihgc5nr	14	23	repeat	repeat	NN
cord-260054-iihgc5nr	14	24	1	1	CD
cord-260054-iihgc5nr	14	25	(	(	-LRB-
cord-260054-iihgc5nr	14	26	HR1	HR1	NNP
cord-260054-iihgc5nr	14	27	)	)	-RRB-
cord-260054-iihgc5nr	14	28	.	.	.
cord-260054-iihgc5nr	15	1	Our	-PRON-	PRP$
cord-260054-iihgc5nr	15	2	modeling	modeling	NN
cord-260054-iihgc5nr	15	3	in	in	IN
cord-260054-iihgc5nr	15	4	the	the	DT
cord-260054-iihgc5nr	15	5	pre-	pre-	JJ
cord-260054-iihgc5nr	15	6	and	and	CC
cord-260054-iihgc5nr	15	7	post	post	JJ
cord-260054-iihgc5nr	15	8	-	-	JJ
cord-260054-iihgc5nr	15	9	fusion	fusion	JJ
cord-260054-iihgc5nr	15	10	S	S	NNP
cord-260054-iihgc5nr	15	11	protein	protein	NN
cord-260054-iihgc5nr	15	12	conformations	conformation	NNS
cord-260054-iihgc5nr	15	13	revealed	reveal	VBD
cord-260054-iihgc5nr	15	14	,	,	,
cord-260054-iihgc5nr	15	15	for	for	IN
cord-260054-iihgc5nr	15	16	three	three	CD
cord-260054-iihgc5nr	15	17	of	of	IN
cord-260054-iihgc5nr	15	18	them	-PRON-	PRP
cord-260054-iihgc5nr	15	19	,	,	,
cord-260054-iihgc5nr	15	20	the	the	DT
cord-260054-iihgc5nr	15	21	loss	loss	NN
cord-260054-iihgc5nr	15	22	of	of	IN
cord-260054-iihgc5nr	15	23	interactions	interaction	NNS
cord-260054-iihgc5nr	15	24	stabilizing	stabilize	VBG
cord-260054-iihgc5nr	15	25	the	the	DT
cord-260054-iihgc5nr	15	26	post	post	JJ
cord-260054-iihgc5nr	15	27	-	-	JJ
cord-260054-iihgc5nr	15	28	fusion	fusion	JJ
cord-260054-iihgc5nr	15	29	assembly	assembly	NN
cord-260054-iihgc5nr	15	30	.	.	.
cord-260054-iihgc5nr	16	1	On	on	IN
cord-260054-iihgc5nr	16	2	May	May	NNP
cord-260054-iihgc5nr	16	3	29th	29th	NN
cord-260054-iihgc5nr	16	4	,	,	,
cord-260054-iihgc5nr	16	5	the	the	DT
cord-260054-iihgc5nr	16	6	SARS	SARS	NNP
cord-260054-iihgc5nr	16	7	-	-	HYPH
cord-260054-iihgc5nr	16	8	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	16	9	genomic	genomic	JJ
cord-260054-iihgc5nr	16	10	sequences	sequence	NNS
cord-260054-iihgc5nr	16	11	in	in	IN
cord-260054-iihgc5nr	16	12	GISAID	GISAID	NNP
cord-260054-iihgc5nr	16	13	were	be	VBD
cord-260054-iihgc5nr	16	14	34,805	34,805	CD
cord-260054-iihgc5nr	16	15	.	.	.
cord-260054-iihgc5nr	17	1	An	an	DT
cord-260054-iihgc5nr	17	2	analysis	analysis	NN
cord-260054-iihgc5nr	17	3	of	of	IN
cord-260054-iihgc5nr	17	4	the	the	DT
cord-260054-iihgc5nr	17	5	occurrences	occurrence	NNS
cord-260054-iihgc5nr	17	6	of	of	IN
cord-260054-iihgc5nr	17	7	the	the	DT
cord-260054-iihgc5nr	17	8	HR1	HR1	NNP
cord-260054-iihgc5nr	17	9	mutations	mutation	NNS
cord-260054-iihgc5nr	17	10	in	in	IN
cord-260054-iihgc5nr	17	11	this	this	DT
cord-260054-iihgc5nr	17	12	updated	update	VBN
cord-260054-iihgc5nr	17	13	dataset	dataset	NN
cord-260054-iihgc5nr	17	14	revealed	reveal	VBD
cord-260054-iihgc5nr	17	15	a	a	DT
cord-260054-iihgc5nr	17	16	significant	significant	JJ
cord-260054-iihgc5nr	17	17	increase	increase	NN
cord-260054-iihgc5nr	17	18	for	for	IN
cord-260054-iihgc5nr	17	19	the	the	DT
cord-260054-iihgc5nr	17	20	S929I	S929I	NNP
cord-260054-iihgc5nr	17	21	and	and	CC
cord-260054-iihgc5nr	17	22	S939F	S939F	NNP
cord-260054-iihgc5nr	17	23	mutations	mutation	NNS
cord-260054-iihgc5nr	17	24	and	and	CC
cord-260054-iihgc5nr	17	25	a	a	DT
cord-260054-iihgc5nr	17	26	dramatic	dramatic	JJ
cord-260054-iihgc5nr	17	27	increase	increase	NN
cord-260054-iihgc5nr	17	28	for	for	IN
cord-260054-iihgc5nr	17	29	the	the	DT
cord-260054-iihgc5nr	17	30	D936Y	d936y	JJ
cord-260054-iihgc5nr	17	31	mutation	mutation	NN
cord-260054-iihgc5nr	17	32	,	,	,
cord-260054-iihgc5nr	17	33	which	which	WDT
cord-260054-iihgc5nr	17	34	was	be	VBD
cord-260054-iihgc5nr	17	35	particularly	particularly	RB
cord-260054-iihgc5nr	17	36	widespread	widespread	JJ
cord-260054-iihgc5nr	17	37	in	in	IN
cord-260054-iihgc5nr	17	38	Sweden	Sweden	NNP
cord-260054-iihgc5nr	17	39	and	and	CC
cord-260054-iihgc5nr	17	40	Wales	Wales	NNP
cord-260054-iihgc5nr	17	41	/	/	SYM
cord-260054-iihgc5nr	17	42	England	England	NNP
cord-260054-iihgc5nr	17	43	.	.	.
cord-260054-iihgc5nr	18	1	We	-PRON-	PRP
cord-260054-iihgc5nr	18	2	notice	notice	VBP
cord-260054-iihgc5nr	18	3	that	that	IN
cord-260054-iihgc5nr	18	4	this	this	DT
cord-260054-iihgc5nr	18	5	is	be	VBZ
cord-260054-iihgc5nr	18	6	also	also	RB
cord-260054-iihgc5nr	18	7	the	the	DT
cord-260054-iihgc5nr	18	8	mutation	mutation	NN
cord-260054-iihgc5nr	18	9	causing	cause	VBG
cord-260054-iihgc5nr	18	10	the	the	DT
cord-260054-iihgc5nr	18	11	loss	loss	NN
cord-260054-iihgc5nr	18	12	of	of	IN
cord-260054-iihgc5nr	18	13	a	a	DT
cord-260054-iihgc5nr	18	14	strong	strong	JJ
cord-260054-iihgc5nr	18	15	inter	inter	JJ
cord-260054-iihgc5nr	18	16	-	-	JJ
cord-260054-iihgc5nr	18	17	monomer	monomer	JJ
cord-260054-iihgc5nr	18	18	interaction	interaction	NN
cord-260054-iihgc5nr	18	19	,	,	,
cord-260054-iihgc5nr	18	20	the	the	DT
cord-260054-iihgc5nr	18	21	D936-R1185	D936-R1185	NNP
cord-260054-iihgc5nr	18	22	salt	salt	NN
cord-260054-iihgc5nr	18	23	bridge	bridge	NN
cord-260054-iihgc5nr	18	24	,	,	,
cord-260054-iihgc5nr	18	25	thus	thus	RB
cord-260054-iihgc5nr	18	26	clearly	clearly	RB
cord-260054-iihgc5nr	18	27	weakening	weaken	VBG
cord-260054-iihgc5nr	18	28	the	the	DT
cord-260054-iihgc5nr	18	29	post	post	JJ
cord-260054-iihgc5nr	18	30	-	-	JJ
cord-260054-iihgc5nr	18	31	fusion	fusion	JJ
cord-260054-iihgc5nr	18	32	assembly	assembly	NN
cord-260054-iihgc5nr	18	33	.	.	.
cord-260054-iihgc5nr	19	1	Coronavirus	Coronavirus	NNP
cord-260054-iihgc5nr	19	2	Disease	Disease	NNP
cord-260054-iihgc5nr	19	3	2019	2019	CD
cord-260054-iihgc5nr	19	4	is	be	VBZ
cord-260054-iihgc5nr	19	5	caused	cause	VBN
cord-260054-iihgc5nr	19	6	by	by	IN
cord-260054-iihgc5nr	19	7	the	the	DT
cord-260054-iihgc5nr	19	8	severe	severe	JJ
cord-260054-iihgc5nr	19	9	acute	acute	JJ
cord-260054-iihgc5nr	19	10	respiratory	respiratory	JJ
cord-260054-iihgc5nr	19	11	syndrome	syndrome	NN
cord-260054-iihgc5nr	19	12	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	19	13	2	2	CD
cord-260054-iihgc5nr	20	1	(	(	-LRB-
cord-260054-iihgc5nr	20	2	SARS	SARS	NNP
cord-260054-iihgc5nr	20	3	-	-	HYPH
cord-260054-iihgc5nr	20	4	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	20	5	)	)	-RRB-
cord-260054-iihgc5nr	20	6	.	.	.
cord-260054-iihgc5nr	21	1	SARS	SARS	NNP
cord-260054-iihgc5nr	21	2	-	-	HYPH
cord-260054-iihgc5nr	21	3	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	21	4	is	be	VBZ
cord-260054-iihgc5nr	21	5	a	a	DT
cord-260054-iihgc5nr	21	6	novel	novel	JJ
cord-260054-iihgc5nr	21	7	virus	virus	NN
cord-260054-iihgc5nr	21	8	belonging	belong	VBG
cord-260054-iihgc5nr	21	9	to	to	IN
cord-260054-iihgc5nr	21	10	the	the	DT
cord-260054-iihgc5nr	21	11	β	β	XX
cord-260054-iihgc5nr	21	12	genus	genus	NN
cord-260054-iihgc5nr	21	13	coronaviruses	coronaviruses	NNP
cord-260054-iihgc5nr	21	14	,	,	,
cord-260054-iihgc5nr	21	15	which	which	WDT
cord-260054-iihgc5nr	21	16	also	also	RB
cord-260054-iihgc5nr	21	17	include	include	VBP
cord-260054-iihgc5nr	21	18	two	two	CD
cord-260054-iihgc5nr	21	19	highly	highly	RB
cord-260054-iihgc5nr	21	20	pathogenic	pathogenic	JJ
cord-260054-iihgc5nr	21	21	human	human	JJ
cord-260054-iihgc5nr	21	22	viruses	virus	NNS
cord-260054-iihgc5nr	21	23	identified	identify	VBN
cord-260054-iihgc5nr	21	24	in	in	IN
cord-260054-iihgc5nr	21	25	the	the	DT
cord-260054-iihgc5nr	21	26	last	last	JJ
cord-260054-iihgc5nr	21	27	two	two	CD
cord-260054-iihgc5nr	21	28	decades	decade	NNS
cord-260054-iihgc5nr	21	29	,	,	,
cord-260054-iihgc5nr	21	30	the	the	DT
cord-260054-iihgc5nr	21	31	severe	severe	JJ
cord-260054-iihgc5nr	21	32	acute	acute	JJ
cord-260054-iihgc5nr	21	33	respiratory	respiratory	JJ
cord-260054-iihgc5nr	21	34	syndrome	syndrome	NN
cord-260054-iihgc5nr	21	35	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	21	36	(	(	-LRB-
cord-260054-iihgc5nr	21	37	SARS	SARS	NNP
cord-260054-iihgc5nr	21	38	-	-	HYPH
cord-260054-iihgc5nr	21	39	CoV	CoV	NNP
cord-260054-iihgc5nr	21	40	)	)	-RRB-
cord-260054-iihgc5nr	21	41	and	and	CC
cord-260054-iihgc5nr	21	42	the	the	DT
cord-260054-iihgc5nr	21	43	Middle	Middle	NNP
cord-260054-iihgc5nr	21	44	East	East	NNP
cord-260054-iihgc5nr	21	45	respiratory	respiratory	JJ
cord-260054-iihgc5nr	21	46	syndrome	syndrome	NN
cord-260054-iihgc5nr	21	47	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	21	48	(	(	-LRB-
cord-260054-iihgc5nr	21	49	MERS	MERS	NNP
cord-260054-iihgc5nr	21	50	-	-	HYPH
cord-260054-iihgc5nr	21	51	CoV	CoV	NNP
cord-260054-iihgc5nr	21	52	)	)	-RRB-
cord-260054-iihgc5nr	21	53	(	(	-LRB-
cord-260054-iihgc5nr	21	54	1	1	LS
cord-260054-iihgc5nr	21	55	)	)	-RRB-
cord-260054-iihgc5nr	21	56	(	(	-LRB-
cord-260054-iihgc5nr	21	57	2	2	LS
cord-260054-iihgc5nr	21	58	)	)	-RRB-
cord-260054-iihgc5nr	21	59	(	(	-LRB-
cord-260054-iihgc5nr	21	60	3	3	CD
cord-260054-iihgc5nr	21	61	)	)	-RRB-
cord-260054-iihgc5nr	21	62	.	.	.
cord-260054-iihgc5nr	22	1	Coronaviruses	coronaviruse	NNS
cord-260054-iihgc5nr	22	2	are	be	VBP
cord-260054-iihgc5nr	22	3	named	name	VBN
cord-260054-iihgc5nr	22	4	after	after	IN
cord-260054-iihgc5nr	22	5	the	the	DT
cord-260054-iihgc5nr	22	6	protruding	protrude	VBG
cord-260054-iihgc5nr	22	7	spike	spike	NN
cord-260054-iihgc5nr	22	8	(	(	-LRB-
cord-260054-iihgc5nr	22	9	S	s	NN
cord-260054-iihgc5nr	22	10	)	)	-RRB-
cord-260054-iihgc5nr	22	11	glycoproteins	glycoprotein	NNS
cord-260054-iihgc5nr	22	12	on	on	IN
cord-260054-iihgc5nr	22	13	their	-PRON-	PRP$
cord-260054-iihgc5nr	22	14	envelope	envelope	NN
cord-260054-iihgc5nr	22	15	,	,	,
cord-260054-iihgc5nr	22	16	giving	give	VBG
cord-260054-iihgc5nr	22	17	a	a	DT
cord-260054-iihgc5nr	22	18	crown	crown	NN
cord-260054-iihgc5nr	22	19	(	(	-LRB-
cord-260054-iihgc5nr	22	20	corona	corona	NN
cord-260054-iihgc5nr	22	21	in	in	IN
cord-260054-iihgc5nr	22	22	latin	latin	NNP
cord-260054-iihgc5nr	22	23	)	)	-RRB-
cord-260054-iihgc5nr	22	24	shape	shape	NN
cord-260054-iihgc5nr	22	25	to	to	IN
cord-260054-iihgc5nr	22	26	the	the	DT
cord-260054-iihgc5nr	22	27	virions	virion	NNS
cord-260054-iihgc5nr	22	28	(	(	-LRB-
cord-260054-iihgc5nr	22	29	4	4	CD
cord-260054-iihgc5nr	22	30	)	)	-RRB-
cord-260054-iihgc5nr	22	31	.	.	.
cord-260054-iihgc5nr	23	1	Of	of	IN
cord-260054-iihgc5nr	23	2	the	the	DT
cord-260054-iihgc5nr	23	3	four	four	CD
cord-260054-iihgc5nr	23	4	structural	structural	JJ
cord-260054-iihgc5nr	23	5	proteins	protein	NNS
cord-260054-iihgc5nr	23	6	of	of	IN
cord-260054-iihgc5nr	23	7	coronavirues	coronavirue	NNS
cord-260054-iihgc5nr	23	8	,	,	,
cord-260054-iihgc5nr	23	9	S	S	NNP
cord-260054-iihgc5nr	23	10	,	,	,
cord-260054-iihgc5nr	23	11	envelope	envelope	NN
cord-260054-iihgc5nr	23	12	(	(	-LRB-
cord-260054-iihgc5nr	23	13	E	E	NNP
cord-260054-iihgc5nr	23	14	)	)	-RRB-
cord-260054-iihgc5nr	23	15	,	,	,
cord-260054-iihgc5nr	23	16	membrane	membrane	NN
cord-260054-iihgc5nr	23	17	(	(	-LRB-
cord-260054-iihgc5nr	23	18	M	M	NNP
cord-260054-iihgc5nr	23	19	)	)	-RRB-
cord-260054-iihgc5nr	23	20	,	,	,
cord-260054-iihgc5nr	23	21	and	and	CC
cord-260054-iihgc5nr	23	22	nucleocapsid	nucleocapsid	NN
cord-260054-iihgc5nr	23	23	(	(	-LRB-
cord-260054-iihgc5nr	23	24	N	N	NNP
cord-260054-iihgc5nr	23	25	)	)	-RRB-
cord-260054-iihgc5nr	23	26	,	,	,
cord-260054-iihgc5nr	23	27	the	the	DT
cord-260054-iihgc5nr	23	28	S	S	NNP
cord-260054-iihgc5nr	23	29	protein	protein	NN
cord-260054-iihgc5nr	23	30	is	be	VBZ
cord-260054-iihgc5nr	23	31	the	the	DT
cord-260054-iihgc5nr	23	32	one	one	NN
cord-260054-iihgc5nr	23	33	playing	play	VBG
cord-260054-iihgc5nr	23	34	a	a	DT
cord-260054-iihgc5nr	23	35	key	key	JJ
cord-260054-iihgc5nr	23	36	role	role	NN
cord-260054-iihgc5nr	23	37	in	in	IN
cord-260054-iihgc5nr	23	38	mediating	mediate	VBG
cord-260054-iihgc5nr	23	39	the	the	DT
cord-260054-iihgc5nr	23	40	viral	viral	JJ
cord-260054-iihgc5nr	23	41	entry	entry	NN
cord-260054-iihgc5nr	23	42	into	into	IN
cord-260054-iihgc5nr	23	43	the	the	DT
cord-260054-iihgc5nr	23	44	host	host	NN
cord-260054-iihgc5nr	23	45	cells	cell	NNS
cord-260054-iihgc5nr	23	46	(	(	-LRB-
cord-260054-iihgc5nr	23	47	5	5	CD
cord-260054-iihgc5nr	23	48	)	)	-RRB-
cord-260054-iihgc5nr	23	49	(	(	-LRB-
cord-260054-iihgc5nr	23	50	6	6	LS
cord-260054-iihgc5nr	23	51	)	)	-RRB-
cord-260054-iihgc5nr	23	52	(	(	-LRB-
cord-260054-iihgc5nr	23	53	7	7	CD
cord-260054-iihgc5nr	23	54	)	)	-RRB-
cord-260054-iihgc5nr	23	55	,	,	,
cord-260054-iihgc5nr	23	56	making	make	VBG
cord-260054-iihgc5nr	23	57	it	-PRON-	PRP
cord-260054-iihgc5nr	23	58	one	one	CD
cord-260054-iihgc5nr	23	59	of	of	IN
cord-260054-iihgc5nr	23	60	the	the	DT
cord-260054-iihgc5nr	23	61	main	main	JJ
cord-260054-iihgc5nr	23	62	targets	target	NNS
cord-260054-iihgc5nr	23	63	for	for	IN
cord-260054-iihgc5nr	23	64	the	the	DT
cord-260054-iihgc5nr	23	65	development	development	NN
cord-260054-iihgc5nr	23	66	of	of	IN
cord-260054-iihgc5nr	23	67	therapeutic	therapeutic	JJ
cord-260054-iihgc5nr	23	68	drugs	drug	NNS
cord-260054-iihgc5nr	23	69	and	and	CC
cord-260054-iihgc5nr	23	70	vaccines	vaccine	NNS
cord-260054-iihgc5nr	23	71	(	(	-LRB-
cord-260054-iihgc5nr	23	72	8)	8)	NNP
cord-260054-iihgc5nr	23	73	(	(	-LRB-
cord-260054-iihgc5nr	23	74	9	9	CD
cord-260054-iihgc5nr	23	75	)	)	-RRB-
cord-260054-iihgc5nr	23	76	(	(	-LRB-
cord-260054-iihgc5nr	23	77	10	10	CD
cord-260054-iihgc5nr	23	78	)	)	-RRB-
cord-260054-iihgc5nr	23	79	(	(	-LRB-
cord-260054-iihgc5nr	23	80	11	11	CD
cord-260054-iihgc5nr	23	81	)	)	-RRB-
cord-260054-iihgc5nr	23	82	(	(	-LRB-
cord-260054-iihgc5nr	23	83	12	12	CD
cord-260054-iihgc5nr	23	84	)	)	-RRB-
cord-260054-iihgc5nr	23	85	(	(	-LRB-
cord-260054-iihgc5nr	23	86	13	13	CD
cord-260054-iihgc5nr	23	87	)	)	-RRB-
cord-260054-iihgc5nr	23	88	(	(	-LRB-
cord-260054-iihgc5nr	23	89	14	14	CD
cord-260054-iihgc5nr	23	90	)	)	-RRB-
cord-260054-iihgc5nr	23	91	.	.	.
cord-260054-iihgc5nr	24	1	Comprised	comprise	VBN
cord-260054-iihgc5nr	24	2	of	of	IN
cord-260054-iihgc5nr	24	3	two	two	CD
cord-260054-iihgc5nr	24	4	functional	functional	JJ
cord-260054-iihgc5nr	24	5	subunits	subunit	NNS
cord-260054-iihgc5nr	24	6	,	,	,
cord-260054-iihgc5nr	24	7	S1	S1	NNP
cord-260054-iihgc5nr	24	8	and	and	CC
cord-260054-iihgc5nr	24	9	S2	S2	NNP
cord-260054-iihgc5nr	24	10	,	,	,
cord-260054-iihgc5nr	24	11	it	-PRON-	PRP
cord-260054-iihgc5nr	24	12	first	first	RB
cord-260054-iihgc5nr	24	13	binds	bind	VBZ
cord-260054-iihgc5nr	24	14	to	to	IN
cord-260054-iihgc5nr	24	15	a	a	DT
cord-260054-iihgc5nr	24	16	host	host	NN
cord-260054-iihgc5nr	24	17	receptor	receptor	NN
cord-260054-iihgc5nr	24	18	through	through	IN
cord-260054-iihgc5nr	24	19	the	the	DT
cord-260054-iihgc5nr	24	20	receptor	receptor	NN
cord-260054-iihgc5nr	24	21	-	-	HYPH
cord-260054-iihgc5nr	24	22	binding	bind	VBG
cord-260054-iihgc5nr	24	23	domain	domain	NN
cord-260054-iihgc5nr	24	24	(	(	-LRB-
cord-260054-iihgc5nr	24	25	RBD	RBD	NNP
cord-260054-iihgc5nr	24	26	)	)	-RRB-
cord-260054-iihgc5nr	24	27	in	in	IN
cord-260054-iihgc5nr	24	28	the	the	DT
cord-260054-iihgc5nr	24	29	S1	S1	NNP
cord-260054-iihgc5nr	24	30	subunit	subunit	NN
cord-260054-iihgc5nr	24	31	and	and	CC
cord-260054-iihgc5nr	24	32	then	then	RB
cord-260054-iihgc5nr	24	33	fuses	fuse	VBZ
cord-260054-iihgc5nr	24	34	the	the	DT
cord-260054-iihgc5nr	24	35	viral	viral	JJ
cord-260054-iihgc5nr	24	36	and	and	CC
cord-260054-iihgc5nr	24	37	host	host	NN
cord-260054-iihgc5nr	24	38	membranes	membrane	NNS
cord-260054-iihgc5nr	24	39	through	through	IN
cord-260054-iihgc5nr	24	40	the	the	DT
cord-260054-iihgc5nr	24	41	S2	S2	NNP
cord-260054-iihgc5nr	24	42	subunit	subunit	NN
cord-260054-iihgc5nr	24	43	(	(	-LRB-
cord-260054-iihgc5nr	24	44	7	7	CD
cord-260054-iihgc5nr	24	45	,	,	,
cord-260054-iihgc5nr	24	46	15	15	CD
cord-260054-iihgc5nr	24	47	)	)	-RRB-
cord-260054-iihgc5nr	24	48	.	.	.
cord-260054-iihgc5nr	25	1	In	in	IN
cord-260054-iihgc5nr	25	2	the	the	DT
cord-260054-iihgc5nr	25	3	prefusion	prefusion	NN
cord-260054-iihgc5nr	25	4	conformation	conformation	NN
cord-260054-iihgc5nr	25	5	,	,	,
cord-260054-iihgc5nr	25	6	the	the	DT
cord-260054-iihgc5nr	25	7	SARS	SARS	NNP
cord-260054-iihgc5nr	25	8	-	-	HYPH
cord-260054-iihgc5nr	25	9	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	25	10	S	S	NNP
cord-260054-iihgc5nr	25	11	protein	protein	NN
cord-260054-iihgc5nr	25	12	forms	form	VBZ
cord-260054-iihgc5nr	25	13	homotrimers	homotrimer	NNS
cord-260054-iihgc5nr	25	14	protruding	protrude	VBG
cord-260054-iihgc5nr	25	15	from	from	IN
cord-260054-iihgc5nr	25	16	the	the	DT
cord-260054-iihgc5nr	25	17	viral	viral	JJ
cord-260054-iihgc5nr	25	18	surface	surface	NN
cord-260054-iihgc5nr	25	19	,	,	,
cord-260054-iihgc5nr	25	20	where	where	WRB
cord-260054-iihgc5nr	25	21	its	-PRON-	PRP$
cord-260054-iihgc5nr	25	22	RBD	RBD	NNP
cord-260054-iihgc5nr	25	23	binds	bind	VBZ
cord-260054-iihgc5nr	25	24	to	to	IN
cord-260054-iihgc5nr	25	25	the	the	DT
cord-260054-iihgc5nr	25	26	angiotensin	angiotensin	NN
cord-260054-iihgc5nr	25	27	-	-	HYPH
cord-260054-iihgc5nr	25	28	converting	convert	VBG
cord-260054-iihgc5nr	25	29	enzyme	enzyme	NN
cord-260054-iihgc5nr	25	30	2	2	CD
cord-260054-iihgc5nr	25	31	(	(	-LRB-
cord-260054-iihgc5nr	25	32	ACE2	ACE2	NNP
cord-260054-iihgc5nr	25	33	)	)	-RRB-
cord-260054-iihgc5nr	25	34	receptor	receptor	NN
cord-260054-iihgc5nr	25	35	on	on	IN
cord-260054-iihgc5nr	25	36	the	the	DT
cord-260054-iihgc5nr	25	37	host	host	NN
cord-260054-iihgc5nr	25	38	cell	cell	NN
cord-260054-iihgc5nr	25	39	surface	surface	NN
cord-260054-iihgc5nr	25	40	(	(	-LRB-
cord-260054-iihgc5nr	25	41	1	1	CD
cord-260054-iihgc5nr	25	42	)	)	-RRB-
cord-260054-iihgc5nr	26	1	(	(	-LRB-
cord-260054-iihgc5nr	26	2	like	like	IN
cord-260054-iihgc5nr	26	3	the	the	DT
cord-260054-iihgc5nr	26	4	SARS	SARS	NNP
cord-260054-iihgc5nr	26	5	-	-	HYPH
cord-260054-iihgc5nr	26	6	CoV	CoV	NNP
cord-260054-iihgc5nr	26	7	homolog	homolog	NN
cord-260054-iihgc5nr	26	8	(	(	-LRB-
cord-260054-iihgc5nr	26	9	16	16	CD
cord-260054-iihgc5nr	26	10	)	)	-RRB-
cord-260054-iihgc5nr	26	11	,	,	,
cord-260054-iihgc5nr	26	12	and	and	CC
cord-260054-iihgc5nr	26	13	differently	differently	RB
cord-260054-iihgc5nr	26	14	from	from	IN
cord-260054-iihgc5nr	26	15	MERS	MERS	NNP
cord-260054-iihgc5nr	26	16	-	-	HYPH
cord-260054-iihgc5nr	26	17	CoV	CoV	NNP
cord-260054-iihgc5nr	26	18	S	S	NNP
cord-260054-iihgc5nr	26	19	,	,	,
cord-260054-iihgc5nr	26	20	which	which	WDT
cord-260054-iihgc5nr	26	21	recognizes	recognize	VBZ
cord-260054-iihgc5nr	26	22	a	a	DT
cord-260054-iihgc5nr	26	23	different	different	JJ
cord-260054-iihgc5nr	26	24	receptor	receptor	NN
cord-260054-iihgc5nr	26	25	,	,	,
cord-260054-iihgc5nr	26	26	the	the	DT
cord-260054-iihgc5nr	26	27	dipeptidyl	dipeptidyl	JJ
cord-260054-iihgc5nr	26	28	peptidase	peptidase	NN
cord-260054-iihgc5nr	26	29	4	4	CD
cord-260054-iihgc5nr	26	30	(	(	-LRB-
cord-260054-iihgc5nr	26	31	17	17	CD
cord-260054-iihgc5nr	26	32	)	)	-RRB-
cord-260054-iihgc5nr	26	33	)	)	-RRB-
cord-260054-iihgc5nr	26	34	.	.	.
cord-260054-iihgc5nr	27	1	Receptor	receptor	NN
cord-260054-iihgc5nr	27	2	binding	binding	NN
cord-260054-iihgc5nr	27	3	and	and	CC
cord-260054-iihgc5nr	27	4	proteolytic	proteolytic	JJ
cord-260054-iihgc5nr	27	5	processing	processing	NN
cord-260054-iihgc5nr	27	6	by	by	IN
cord-260054-iihgc5nr	27	7	cellular	cellular	JJ
cord-260054-iihgc5nr	27	8	proteases	protease	NNS
cord-260054-iihgc5nr	27	9	then	then	RB
cord-260054-iihgc5nr	27	10	cause	cause	VBP
cord-260054-iihgc5nr	27	11	S1	s1	NN
cord-260054-iihgc5nr	27	12	to	to	TO
cord-260054-iihgc5nr	27	13	dissociate	dissociate	VB
cord-260054-iihgc5nr	27	14	and	and	CC
cord-260054-iihgc5nr	27	15	S2	S2	NNP
cord-260054-iihgc5nr	27	16	to	to	TO
cord-260054-iihgc5nr	27	17	undergo	undergo	VB
cord-260054-iihgc5nr	27	18	large	large	JJ
cord-260054-iihgc5nr	27	19	-	-	HYPH
cord-260054-iihgc5nr	27	20	scale	scale	NN
cord-260054-iihgc5nr	27	21	conformational	conformational	JJ
cord-260054-iihgc5nr	27	22	changes	change	NNS
cord-260054-iihgc5nr	27	23	towards	towards	IN
cord-260054-iihgc5nr	27	24	a	a	DT
cord-260054-iihgc5nr	27	25	stable	stable	JJ
cord-260054-iihgc5nr	27	26	structure	structure	NN
cord-260054-iihgc5nr	27	27	,	,	,
cord-260054-iihgc5nr	27	28	bringing	bring	VBG
cord-260054-iihgc5nr	27	29	viral	viral	JJ
cord-260054-iihgc5nr	27	30	and	and	CC
cord-260054-iihgc5nr	27	31	cellular	cellular	JJ
cord-260054-iihgc5nr	27	32	membranes	membrane	NNS
cord-260054-iihgc5nr	27	33	into	into	IN
cord-260054-iihgc5nr	27	34	close	close	JJ
cord-260054-iihgc5nr	27	35	proximity	proximity	NN
cord-260054-iihgc5nr	27	36	for	for	IN
cord-260054-iihgc5nr	27	37	fusion	fusion	NN
cord-260054-iihgc5nr	27	38	and	and	CC
cord-260054-iihgc5nr	27	39	infection	infection	NN
cord-260054-iihgc5nr	27	40	(	(	-LRB-
cord-260054-iihgc5nr	27	41	7	7	CD
cord-260054-iihgc5nr	27	42	,	,	,
cord-260054-iihgc5nr	27	43	15	15	CD
cord-260054-iihgc5nr	27	44	,	,	,
cord-260054-iihgc5nr	27	45	18	18	CD
cord-260054-iihgc5nr	27	46	)	)	-RRB-
cord-260054-iihgc5nr	27	47	.	.	.
cord-260054-iihgc5nr	28	1	While	while	IN
cord-260054-iihgc5nr	28	2	the	the	DT
cord-260054-iihgc5nr	28	3	outbreak	outbreak	NN
cord-260054-iihgc5nr	28	4	of	of	IN
cord-260054-iihgc5nr	28	5	COVID-19	COVID-19	NNP
cord-260054-iihgc5nr	28	6	was	be	VBD
cord-260054-iihgc5nr	28	7	rapidly	rapidly	RB
cord-260054-iihgc5nr	28	8	spreading	spread	VBG
cord-260054-iihgc5nr	28	9	all	all	RB
cord-260054-iihgc5nr	28	10	over	over	IN
cord-260054-iihgc5nr	28	11	the	the	DT
cord-260054-iihgc5nr	28	12	world	world	NN
cord-260054-iihgc5nr	28	13	,	,	,
cord-260054-iihgc5nr	28	14	affecting	affect	VBG
cord-260054-iihgc5nr	28	15	millions	million	NNS
cord-260054-iihgc5nr	28	16	of	of	IN
cord-260054-iihgc5nr	28	17	people	people	NNS
cord-260054-iihgc5nr	28	18	and	and	CC
cord-260054-iihgc5nr	28	19	becoming	become	VBG
cord-260054-iihgc5nr	28	20	a	a	DT
cord-260054-iihgc5nr	28	21	global	global	JJ
cord-260054-iihgc5nr	28	22	threat	threat	NN
cord-260054-iihgc5nr	28	23	,	,	,
cord-260054-iihgc5nr	28	24	laboratories	laboratory	NNS
cord-260054-iihgc5nr	28	25	worldwide	worldwide	RB
cord-260054-iihgc5nr	28	26	promptly	promptly	RB
cord-260054-iihgc5nr	28	27	started	start	VBD
cord-260054-iihgc5nr	28	28	to	to	TO
cord-260054-iihgc5nr	28	29	sequence	sequence	VB
cord-260054-iihgc5nr	28	30	a	a	DT
cord-260054-iihgc5nr	28	31	large	large	JJ
cord-260054-iihgc5nr	28	32	number	number	NN
cord-260054-iihgc5nr	28	33	of	of	IN
cord-260054-iihgc5nr	28	34	SARS	SARS	NNP
cord-260054-iihgc5nr	28	35	-	-	HYPH
cord-260054-iihgc5nr	28	36	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	28	37	genomes	genome	NNS
cord-260054-iihgc5nr	28	38	.	.	.
cord-260054-iihgc5nr	29	1	All	all	PDT
cord-260054-iihgc5nr	29	2	the	the	DT
cord-260054-iihgc5nr	29	3	available	available	JJ
cord-260054-iihgc5nr	29	4	genomic	genomic	JJ
cord-260054-iihgc5nr	29	5	data	datum	NNS
cord-260054-iihgc5nr	29	6	is	be	VBZ
cord-260054-iihgc5nr	29	7	accessible	accessible	JJ
cord-260054-iihgc5nr	29	8	through	through	IN
cord-260054-iihgc5nr	29	9	the	the	DT
cord-260054-iihgc5nr	29	10	Global	Global	NNP
cord-260054-iihgc5nr	29	11	Initiative	Initiative	NNP
cord-260054-iihgc5nr	29	12	on	on	IN
cord-260054-iihgc5nr	29	13	Sharing	Sharing	NNP
cord-260054-iihgc5nr	29	14	All	all	DT
cord-260054-iihgc5nr	29	15	Influenza	Influenza	NNP
cord-260054-iihgc5nr	29	16	Data	Data	NNP
cord-260054-iihgc5nr	29	17	(	(	-LRB-
cord-260054-iihgc5nr	29	18	GISAID	GISAID	NNP
cord-260054-iihgc5nr	29	19	)	)	-RRB-
cord-260054-iihgc5nr	29	20	website	website	NN
cord-260054-iihgc5nr	29	21	,	,	,
cord-260054-iihgc5nr	29	22	an	an	DT
cord-260054-iihgc5nr	29	23	invaluable	invaluable	JJ
cord-260054-iihgc5nr	29	24	open	open	JJ
cord-260054-iihgc5nr	29	25	access	access	NN
cord-260054-iihgc5nr	29	26	resource	resource	NN
cord-260054-iihgc5nr	29	27	(	(	-LRB-
cord-260054-iihgc5nr	29	28	19	19	CD
cord-260054-iihgc5nr	29	29	,	,	,
cord-260054-iihgc5nr	29	30	20	20	CD
cord-260054-iihgc5nr	29	31	)	)	-RRB-
cord-260054-iihgc5nr	29	32	.	.	.
cord-260054-iihgc5nr	30	1	Simultaneously	simultaneously	RB
cord-260054-iihgc5nr	30	2	,	,	,
cord-260054-iihgc5nr	30	3	crucial	crucial	JJ
cord-260054-iihgc5nr	30	4	structural	structural	JJ
cord-260054-iihgc5nr	30	5	knowledge	knowledge	NN
cord-260054-iihgc5nr	30	6	has	have	VBZ
cord-260054-iihgc5nr	30	7	been	be	VBN
cord-260054-iihgc5nr	30	8	achieved	achieve	VBN
cord-260054-iihgc5nr	30	9	on	on	IN
cord-260054-iihgc5nr	30	10	SARS	SARS	NNP
cord-260054-iihgc5nr	30	11	-	-	HYPH
cord-260054-iihgc5nr	30	12	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	30	13	,	,	,
cord-260054-iihgc5nr	30	14	especially	especially	RB
cord-260054-iihgc5nr	30	15	regarding	regard	VBG
cord-260054-iihgc5nr	30	16	the	the	DT
cord-260054-iihgc5nr	30	17	S	S	NNP
cord-260054-iihgc5nr	30	18	protein	protein	NN
cord-260054-iihgc5nr	30	19	.	.	.
cord-260054-iihgc5nr	31	1	3D	3d	JJ
cord-260054-iihgc5nr	31	2	structures	structure	NNS
cord-260054-iihgc5nr	31	3	are	be	VBP
cord-260054-iihgc5nr	31	4	now	now	RB
cord-260054-iihgc5nr	31	5	available	available	JJ
cord-260054-iihgc5nr	31	6	from	from	IN
cord-260054-iihgc5nr	31	7	the	the	DT
cord-260054-iihgc5nr	31	8	Protein	Protein	NNP
cord-260054-iihgc5nr	31	9	Data	Data	NNP
cord-260054-iihgc5nr	31	10	Bank	Bank	NNP
cord-260054-iihgc5nr	31	11	(	(	-LRB-
cord-260054-iihgc5nr	31	12	PDB	PDB	NNP
cord-260054-iihgc5nr	31	13	)	)	-RRB-
cord-260054-iihgc5nr	31	14	(	(	-LRB-
cord-260054-iihgc5nr	31	15	21	21	CD
cord-260054-iihgc5nr	31	16	)	)	-RRB-
cord-260054-iihgc5nr	31	17	for	for	IN
cord-260054-iihgc5nr	31	18	the	the	DT
cord-260054-iihgc5nr	31	19	SARS	SARS	NNP
cord-260054-iihgc5nr	31	20	-	-	HYPH
cord-260054-iihgc5nr	31	21	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	31	22	S	S	NNP
cord-260054-iihgc5nr	31	23	protein	protein	NN
cord-260054-iihgc5nr	31	24	in	in	IN
cord-260054-iihgc5nr	31	25	the	the	DT
cord-260054-iihgc5nr	31	26	pre	pre	JJ
cord-260054-iihgc5nr	31	27	-	-	JJ
cord-260054-iihgc5nr	31	28	fusion	fusion	JJ
cord-260054-iihgc5nr	31	29	conformation	conformation	NN
cord-260054-iihgc5nr	31	30	,	,	,
cord-260054-iihgc5nr	31	31	also	also	RB
cord-260054-iihgc5nr	31	32	bound	bind	VBN
cord-260054-iihgc5nr	31	33	to	to	IN
cord-260054-iihgc5nr	31	34	the	the	DT
cord-260054-iihgc5nr	31	35	ACE2	ACE2	NNP
cord-260054-iihgc5nr	31	36	receptor	receptor	NN
cord-260054-iihgc5nr	31	37	(	(	-LRB-
cord-260054-iihgc5nr	31	38	22	22	CD
cord-260054-iihgc5nr	31	39	)	)	-RRB-
cord-260054-iihgc5nr	31	40	(	(	-LRB-
cord-260054-iihgc5nr	31	41	23	23	CD
cord-260054-iihgc5nr	31	42	)	)	-RRB-
cord-260054-iihgc5nr	31	43	(	(	-LRB-
cord-260054-iihgc5nr	31	44	24	24	CD
cord-260054-iihgc5nr	31	45	)	)	-RRB-
cord-260054-iihgc5nr	31	46	(	(	-LRB-
cord-260054-iihgc5nr	31	47	25	25	CD
cord-260054-iihgc5nr	31	48	)	)	-RRB-
cord-260054-iihgc5nr	31	49	(	(	-LRB-
cord-260054-iihgc5nr	31	50	26	26	CD
cord-260054-iihgc5nr	31	51	)	)	-RRB-
cord-260054-iihgc5nr	31	52	(	(	-LRB-
cord-260054-iihgc5nr	31	53	27	27	CD
cord-260054-iihgc5nr	31	54	)	)	-RRB-
cord-260054-iihgc5nr	31	55	(	(	-LRB-
cord-260054-iihgc5nr	31	56	28	28	CD
cord-260054-iihgc5nr	31	57	)	)	-RRB-
cord-260054-iihgc5nr	31	58	,	,	,
cord-260054-iihgc5nr	31	59	and	and	CC
cord-260054-iihgc5nr	31	60	for	for	IN
cord-260054-iihgc5nr	31	61	the	the	DT
cord-260054-iihgc5nr	31	62	post	post	JJ
cord-260054-iihgc5nr	31	63	-	-	JJ
cord-260054-iihgc5nr	31	64	fusion	fusion	JJ
cord-260054-iihgc5nr	31	65	core	core	NN
cord-260054-iihgc5nr	31	66	of	of	IN
cord-260054-iihgc5nr	31	67	its	-PRON-	PRP$
cord-260054-iihgc5nr	31	68	S2	S2	NNP
cord-260054-iihgc5nr	31	69	subunit	subunit	NN
cord-260054-iihgc5nr	31	70	in	in	IN
cord-260054-iihgc5nr	31	71	the	the	DT
cord-260054-iihgc5nr	31	72	postfusion	postfusion	NN
cord-260054-iihgc5nr	31	73	conformation	conformation	NN
cord-260054-iihgc5nr	31	74	(	(	-LRB-
cord-260054-iihgc5nr	31	75	29	29	CD
cord-260054-iihgc5nr	31	76	)	)	-RRB-
cord-260054-iihgc5nr	31	77	.	.	.
cord-260054-iihgc5nr	32	1	On	on	IN
cord-260054-iihgc5nr	32	2	April	April	NNP
cord-260054-iihgc5nr	32	3	21	21	CD
cord-260054-iihgc5nr	32	4	st	st	NNP
cord-260054-iihgc5nr	32	5	2020	2020	CD
cord-260054-iihgc5nr	32	6	,	,	,
cord-260054-iihgc5nr	32	7	4	4	CD
cord-260054-iihgc5nr	32	8	months	month	NNS
cord-260054-iihgc5nr	32	9	after	after	IN
cord-260054-iihgc5nr	32	10	the	the	DT
cord-260054-iihgc5nr	32	11	first	first	JJ
cord-260054-iihgc5nr	32	12	sequencing	sequencing	NN
cord-260054-iihgc5nr	32	13	(	(	-LRB-
cord-260054-iihgc5nr	32	14	30	30	CD
cord-260054-iihgc5nr	32	15	)	)	-RRB-
cord-260054-iihgc5nr	32	16	,	,	,
cord-260054-iihgc5nr	32	17	10,823	10,823	CD
cord-260054-iihgc5nr	32	18	genomic	genomic	JJ
cord-260054-iihgc5nr	32	19	sequences	sequence	NNS
cord-260054-iihgc5nr	32	20	of	of	IN
cord-260054-iihgc5nr	32	21	SARS	SARS	NNP
cord-260054-iihgc5nr	32	22	-	-	HYPH
cord-260054-iihgc5nr	32	23	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	32	24	were	be	VBD
cord-260054-iihgc5nr	32	25	available	available	JJ
cord-260054-iihgc5nr	32	26	from	from	IN
cord-260054-iihgc5nr	32	27	GISAID	GISAID	NNP
cord-260054-iihgc5nr	32	28	.	.	.
cord-260054-iihgc5nr	33	1	Therefore	therefore	RB
cord-260054-iihgc5nr	33	2	,	,	,
cord-260054-iihgc5nr	33	3	we	-PRON-	PRP
cord-260054-iihgc5nr	33	4	considered	consider	VBD
cord-260054-iihgc5nr	33	5	the	the	DT
cord-260054-iihgc5nr	33	6	time	time	NN
cord-260054-iihgc5nr	33	7	ripe	ripe	JJ
cord-260054-iihgc5nr	33	8	for	for	IN
cord-260054-iihgc5nr	33	9	an	an	DT
cord-260054-iihgc5nr	33	10	assessment	assessment	NN
cord-260054-iihgc5nr	33	11	of	of	IN
cord-260054-iihgc5nr	33	12	the	the	DT
cord-260054-iihgc5nr	33	13	mutational	mutational	JJ
cord-260054-iihgc5nr	33	14	spectrum	spectrum	NN
cord-260054-iihgc5nr	33	15	of	of	IN
cord-260054-iihgc5nr	33	16	the	the	DT
cord-260054-iihgc5nr	33	17	SARS	SARS	NNP
cord-260054-iihgc5nr	33	18	-	-	HYPH
cord-260054-iihgc5nr	33	19	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	33	20	spike	spike	NN
cord-260054-iihgc5nr	33	21	protein	protein	NN
cord-260054-iihgc5nr	33	22	.	.	.
cord-260054-iihgc5nr	34	1	To	to	IN
cord-260054-iihgc5nr	34	2	this	this	DT
cord-260054-iihgc5nr	34	3	aim	aim	NN
cord-260054-iihgc5nr	34	4	,	,	,
cord-260054-iihgc5nr	34	5	we	-PRON-	PRP
cord-260054-iihgc5nr	34	6	extracted	extract	VBD
cord-260054-iihgc5nr	34	7	all	all	PDT
cord-260054-iihgc5nr	34	8	the	the	DT
cord-260054-iihgc5nr	34	9	complete	complete	JJ
cord-260054-iihgc5nr	34	10	S	S	NNP
cord-260054-iihgc5nr	34	11	protein	protein	NN
cord-260054-iihgc5nr	34	12	sequences	sequence	NNS
cord-260054-iihgc5nr	34	13	from	from	IN
cord-260054-iihgc5nr	34	14	the	the	DT
cord-260054-iihgc5nr	34	15	GISAID	GISAID	NNP
cord-260054-iihgc5nr	34	16	21	21	CD
cord-260054-iihgc5nr	34	17	st	st	NNP
cord-260054-iihgc5nr	34	18	April	April	NNP
cord-260054-iihgc5nr	34	19	dataset	dataset	NN
cord-260054-iihgc5nr	34	20	and	and	CC
cord-260054-iihgc5nr	34	21	identified	identify	VBD
cord-260054-iihgc5nr	34	22	all	all	PDT
cord-260054-iihgc5nr	34	23	the	the	DT
cord-260054-iihgc5nr	34	24	mutations	mutation	NNS
cord-260054-iihgc5nr	34	25	occurring	occur	VBG
cord-260054-iihgc5nr	34	26	in	in	IN
cord-260054-iihgc5nr	34	27	at	at	RB
cord-260054-iihgc5nr	34	28	least	least	JJS
cord-260054-iihgc5nr	34	29	2	2	CD
cord-260054-iihgc5nr	34	30	identical	identical	JJ
cord-260054-iihgc5nr	34	31	sequences	sequence	NNS
cord-260054-iihgc5nr	34	32	(	(	-LRB-
cord-260054-iihgc5nr	34	33	see	see	VB
cord-260054-iihgc5nr	34	34	Table	Table	NNP
cord-260054-iihgc5nr	34	35	S1	S1	NNP
cord-260054-iihgc5nr	34	36	)	)	-RRB-
cord-260054-iihgc5nr	34	37	.	.	.
cord-260054-iihgc5nr	35	1	From	from	IN
cord-260054-iihgc5nr	35	2	this	this	DT
cord-260054-iihgc5nr	35	3	analysis	analysis	NN
cord-260054-iihgc5nr	35	4	,	,	,
cord-260054-iihgc5nr	35	5	a	a	DT
cord-260054-iihgc5nr	35	6	14-amino	14-amino	CD
cord-260054-iihgc5nr	35	7	acid	acid	NN
cord-260054-iihgc5nr	35	8	segment	segment	NN
cord-260054-iihgc5nr	35	9	in	in	IN
cord-260054-iihgc5nr	35	10	the	the	DT
cord-260054-iihgc5nr	35	11	fusion	fusion	NN
cord-260054-iihgc5nr	35	12	core	core	NN
cord-260054-iihgc5nr	35	13	of	of	IN
cord-260054-iihgc5nr	35	14	the	the	DT
cord-260054-iihgc5nr	35	15	heptad	heptad	NN
cord-260054-iihgc5nr	35	16	repeat	repeat	NN
cord-260054-iihgc5nr	35	17	1	1	CD
cord-260054-iihgc5nr	35	18	(	(	-LRB-
cord-260054-iihgc5nr	35	19	HR1	HR1	NNP
cord-260054-iihgc5nr	35	20	)	)	-RRB-
cord-260054-iihgc5nr	35	21	emerged	emerge	VBD
cord-260054-iihgc5nr	35	22	as	as	IN
cord-260054-iihgc5nr	35	23	a	a	DT
cord-260054-iihgc5nr	35	24	hotspot	hotspot	NN
cord-260054-iihgc5nr	35	25	for	for	IN
cord-260054-iihgc5nr	35	26	mutations	mutation	NNS
cord-260054-iihgc5nr	35	27	.	.	.
cord-260054-iihgc5nr	36	1	While	while	IN
cord-260054-iihgc5nr	36	2	the	the	DT
cord-260054-iihgc5nr	36	3	mutations	mutation	NNS
cord-260054-iihgc5nr	36	4	we	-PRON-	PRP
cord-260054-iihgc5nr	36	5	identified	identify	VBD
cord-260054-iihgc5nr	36	6	corresponded	correspond	VBD
cord-260054-iihgc5nr	36	7	to	to	IN
cord-260054-iihgc5nr	36	8	a	a	DT
cord-260054-iihgc5nr	36	9	1	1	CD
cord-260054-iihgc5nr	36	10	mutation	mutation	NN
cord-260054-iihgc5nr	36	11	every	every	DT
cord-260054-iihgc5nr	36	12	12	12	CD
cord-260054-iihgc5nr	36	13	positions	position	NNS
cord-260054-iihgc5nr	36	14	along	along	IN
cord-260054-iihgc5nr	36	15	the	the	DT
cord-260054-iihgc5nr	36	16	protein	protein	NN
cord-260054-iihgc5nr	36	17	sequence	sequence	NN
cord-260054-iihgc5nr	36	18	,	,	,
cord-260054-iihgc5nr	36	19	as	as	RB
cord-260054-iihgc5nr	36	20	many	many	JJ
cord-260054-iihgc5nr	36	21	as	as	IN
cord-260054-iihgc5nr	36	22	6	6	CD
cord-260054-iihgc5nr	36	23	amino	amino	NN
cord-260054-iihgc5nr	36	24	acids	acid	NNS
cord-260054-iihgc5nr	36	25	were	be	VBD
cord-260054-iihgc5nr	36	26	found	find	VBN
cord-260054-iihgc5nr	36	27	to	to	TO
cord-260054-iihgc5nr	36	28	be	be	VB
cord-260054-iihgc5nr	36	29	mutated	mutate	VBN
cord-260054-iihgc5nr	36	30	in	in	IN
cord-260054-iihgc5nr	36	31	the	the	DT
cord-260054-iihgc5nr	36	32	above	above	JJ
cord-260054-iihgc5nr	36	33	14-amino	14-amino	CD
cord-260054-iihgc5nr	36	34	acid	acid	NN
cord-260054-iihgc5nr	36	35	segment	segment	NN
cord-260054-iihgc5nr	36	36	:	:	:
cord-260054-iihgc5nr	36	37	S929	s929	JJ
cord-260054-iihgc5nr	36	38	,	,	,
cord-260054-iihgc5nr	36	39	D936	d936	XX
cord-260054-iihgc5nr	36	40	,	,	,
cord-260054-iihgc5nr	36	41	L938	L938	NNP
cord-260054-iihgc5nr	36	42	,	,	,
cord-260054-iihgc5nr	36	43	S939	S939	NNP
cord-260054-iihgc5nr	36	44	,	,	,
cord-260054-iihgc5nr	36	45	S940	S940	NNP
cord-260054-iihgc5nr	36	46	and	and	CC
cord-260054-iihgc5nr	36	47	S943	S943	NNP
cord-260054-iihgc5nr	36	48	.	.	.
cord-260054-iihgc5nr	37	1	After	after	IN
cord-260054-iihgc5nr	37	2	the	the	DT
cord-260054-iihgc5nr	37	3	proteolytic	proteolytic	JJ
cord-260054-iihgc5nr	37	4	processing	processing	NN
cord-260054-iihgc5nr	37	5	,	,	,
cord-260054-iihgc5nr	37	6	in	in	IN
cord-260054-iihgc5nr	37	7	the	the	DT
cord-260054-iihgc5nr	37	8	post	post	JJ
cord-260054-iihgc5nr	37	9	-	-	JJ
cord-260054-iihgc5nr	37	10	fusion	fusion	JJ
cord-260054-iihgc5nr	37	11	conformation	conformation	NN
cord-260054-iihgc5nr	37	12	,	,	,
cord-260054-iihgc5nr	37	13	the	the	DT
cord-260054-iihgc5nr	37	14	S	S	NNP
cord-260054-iihgc5nr	37	15	protein	protein	NN
cord-260054-iihgc5nr	37	16	HR1	HR1	NNP
cord-260054-iihgc5nr	37	17	and	and	CC
cord-260054-iihgc5nr	37	18	HR2	HR2	NNP
cord-260054-iihgc5nr	37	19	motifs	motif	NNS
cord-260054-iihgc5nr	37	20	interact	interact	VBP
cord-260054-iihgc5nr	37	21	with	with	IN
cord-260054-iihgc5nr	37	22	each	each	DT
cord-260054-iihgc5nr	37	23	other	other	JJ
cord-260054-iihgc5nr	37	24	to	to	TO
cord-260054-iihgc5nr	37	25	form	form	VB
cord-260054-iihgc5nr	37	26	a	a	DT
cord-260054-iihgc5nr	37	27	six	six	CD
cord-260054-iihgc5nr	37	28	-	-	HYPH
cord-260054-iihgc5nr	37	29	helix	helix	NN
cord-260054-iihgc5nr	37	30	bundle	bundle	NN
cord-260054-iihgc5nr	37	31	(	(	-LRB-
cord-260054-iihgc5nr	37	32	6-HB	6-hb	CD
cord-260054-iihgc5nr	37	33	)	)	-RRB-
cord-260054-iihgc5nr	37	34	,	,	,
cord-260054-iihgc5nr	37	35	which	which	WDT
cord-260054-iihgc5nr	37	36	promotes	promote	VBZ
cord-260054-iihgc5nr	37	37	initiation	initiation	NN
cord-260054-iihgc5nr	37	38	of	of	IN
cord-260054-iihgc5nr	37	39	the	the	DT
cord-260054-iihgc5nr	37	40	viral	viral	JJ
cord-260054-iihgc5nr	37	41	and	and	CC
cord-260054-iihgc5nr	37	42	cellular	cellular	JJ
cord-260054-iihgc5nr	37	43	membranes	membrane	NNS
cord-260054-iihgc5nr	37	44	fusion	fusion	NN
cord-260054-iihgc5nr	37	45	.	.	.
cord-260054-iihgc5nr	38	1	The	the	DT
cord-260054-iihgc5nr	38	2	HR1	HR1	NNP
cord-260054-iihgc5nr	38	3	"	"	``
cord-260054-iihgc5nr	38	4	fusion	fusion	NN
cord-260054-iihgc5nr	38	5	core	core	NN
cord-260054-iihgc5nr	38	6	"	"	''
cord-260054-iihgc5nr	38	7	is	be	VBZ
cord-260054-iihgc5nr	38	8	named	name	VBN
cord-260054-iihgc5nr	38	9	after	after	IN
cord-260054-iihgc5nr	38	10	its	-PRON-	PRP$
cord-260054-iihgc5nr	38	11	role	role	NN
cord-260054-iihgc5nr	38	12	in	in	IN
cord-260054-iihgc5nr	38	13	giving	give	VBG
cord-260054-iihgc5nr	38	14	many	many	JJ
cord-260054-iihgc5nr	38	15	interactions	interaction	NNS
cord-260054-iihgc5nr	38	16	with	with	IN
cord-260054-iihgc5nr	38	17	HR2	HR2	NNP
cord-260054-iihgc5nr	38	18	in	in	IN
cord-260054-iihgc5nr	38	19	the	the	DT
cord-260054-iihgc5nr	38	20	post	post	JJ
cord-260054-iihgc5nr	38	21	-	-	JJ
cord-260054-iihgc5nr	38	22	fusion	fusion	JJ
cord-260054-iihgc5nr	38	23	conformation	conformation	NN
cord-260054-iihgc5nr	38	24	,	,	,
cord-260054-iihgc5nr	38	25	thus	thus	RB
cord-260054-iihgc5nr	38	26	playing	play	VBG
cord-260054-iihgc5nr	38	27	a	a	DT
cord-260054-iihgc5nr	38	28	key	key	JJ
cord-260054-iihgc5nr	38	29	role	role	NN
cord-260054-iihgc5nr	38	30	in	in	IN
cord-260054-iihgc5nr	38	31	the	the	DT
cord-260054-iihgc5nr	38	32	virus	virus	NN
cord-260054-iihgc5nr	38	33	infectivity	infectivity	NN
cord-260054-iihgc5nr	38	34	(	(	-LRB-
cord-260054-iihgc5nr	38	35	31	31	CD
cord-260054-iihgc5nr	38	36	)	)	-RRB-
cord-260054-iihgc5nr	38	37	.	.	.
cord-260054-iihgc5nr	39	1	Based	base	VBN
cord-260054-iihgc5nr	39	2	on	on	IN
cord-260054-iihgc5nr	39	3	the	the	DT
cord-260054-iihgc5nr	39	4	structural	structural	JJ
cord-260054-iihgc5nr	39	5	location	location	NN
cord-260054-iihgc5nr	39	6	of	of	IN
cord-260054-iihgc5nr	39	7	the	the	DT
cord-260054-iihgc5nr	39	8	above	above	RB
cord-260054-iihgc5nr	39	9	highly	highly	RB
cord-260054-iihgc5nr	39	10	concentrated	concentrated	JJ
cord-260054-iihgc5nr	39	11	mutations	mutation	NNS
cord-260054-iihgc5nr	39	12	and	and	CC
cord-260054-iihgc5nr	39	13	on	on	IN
cord-260054-iihgc5nr	39	14	their	-PRON-	PRP$
cord-260054-iihgc5nr	39	15	nonconservative	nonconservative	JJ
cord-260054-iihgc5nr	39	16	nature	nature	NN
cord-260054-iihgc5nr	39	17	,	,	,
cord-260054-iihgc5nr	39	18	we	-PRON-	PRP
cord-260054-iihgc5nr	39	19	considered	consider	VBD
cord-260054-iihgc5nr	39	20	them	-PRON-	PRP
cord-260054-iihgc5nr	39	21	of	of	IN
cord-260054-iihgc5nr	39	22	particular	particular	JJ
cord-260054-iihgc5nr	39	23	interest	interest	NN
cord-260054-iihgc5nr	39	24	and	and	CC
cord-260054-iihgc5nr	39	25	decided	decide	VBD
cord-260054-iihgc5nr	39	26	to	to	TO
cord-260054-iihgc5nr	39	27	further	further	RB
cord-260054-iihgc5nr	39	28	investigate	investigate	VB
cord-260054-iihgc5nr	39	29	their	-PRON-	PRP$
cord-260054-iihgc5nr	39	30	structural	structural	JJ
cord-260054-iihgc5nr	39	31	basis	basis	NN
cord-260054-iihgc5nr	39	32	,	,	,
cord-260054-iihgc5nr	39	33	both	both	CC
cord-260054-iihgc5nr	39	34	in	in	IN
cord-260054-iihgc5nr	39	35	the	the	DT
cord-260054-iihgc5nr	39	36	pre	pre	NN
cord-260054-iihgc5nr	39	37	-	-	JJ
cord-260054-iihgc5nr	39	38	and	and	CC
cord-260054-iihgc5nr	39	39	post	post	JJ
cord-260054-iihgc5nr	39	40	-	-	JJ
cord-260054-iihgc5nr	39	41	fusion	fusion	JJ
cord-260054-iihgc5nr	39	42	conformation	conformation	NN
cord-260054-iihgc5nr	39	43	,	,	,
cord-260054-iihgc5nr	39	44	as	as	RB
cord-260054-iihgc5nr	39	45	well	well	RB
cord-260054-iihgc5nr	39	46	as	as	IN
cord-260054-iihgc5nr	39	47	their	-PRON-	PRP$
cord-260054-iihgc5nr	39	48	sequencing	sequencing	NN
cord-260054-iihgc5nr	39	49	dates	date	NNS
cord-260054-iihgc5nr	39	50	and	and	CC
cord-260054-iihgc5nr	39	51	geographical	geographical	JJ
cord-260054-iihgc5nr	39	52	distribution	distribution	NN
cord-260054-iihgc5nr	39	53	.	.	.
cord-260054-iihgc5nr	40	1	As	as	IN
cord-260054-iihgc5nr	40	2	we	-PRON-	PRP
cord-260054-iihgc5nr	40	3	show	show	VBP
cord-260054-iihgc5nr	40	4	in	in	IN
cord-260054-iihgc5nr	40	5	the	the	DT
cord-260054-iihgc5nr	40	6	following	following	NN
cord-260054-iihgc5nr	40	7	,	,	,
cord-260054-iihgc5nr	40	8	as	as	RB
cord-260054-iihgc5nr	40	9	many	many	JJ
cord-260054-iihgc5nr	40	10	as	as	IN
cord-260054-iihgc5nr	40	11	three	three	CD
cord-260054-iihgc5nr	40	12	of	of	IN
cord-260054-iihgc5nr	40	13	them	-PRON-	PRP
cord-260054-iihgc5nr	40	14	are	be	VBP
cord-260054-iihgc5nr	40	15	responsible	responsible	JJ
cord-260054-iihgc5nr	40	16	for	for	IN
cord-260054-iihgc5nr	40	17	the	the	DT
cord-260054-iihgc5nr	40	18	loss	loss	NN
cord-260054-iihgc5nr	40	19	of	of	IN
cord-260054-iihgc5nr	40	20	inter	inter	JJ
cord-260054-iihgc5nr	40	21	-	-	JJ
cord-260054-iihgc5nr	40	22	monomer	monomer	JJ
cord-260054-iihgc5nr	40	23	Hbonds	Hbonds	NNP
cord-260054-iihgc5nr	40	24	in	in	IN
cord-260054-iihgc5nr	40	25	the	the	DT
cord-260054-iihgc5nr	40	26	post	post	JJ
cord-260054-iihgc5nr	40	27	-	-	JJ
cord-260054-iihgc5nr	40	28	fusion	fusion	JJ
cord-260054-iihgc5nr	40	29	conformation	conformation	NN
cord-260054-iihgc5nr	40	30	,	,	,
cord-260054-iihgc5nr	40	31	while	while	IN
cord-260054-iihgc5nr	40	32	one	one	CD
cord-260054-iihgc5nr	40	33	of	of	IN
cord-260054-iihgc5nr	40	34	them	-PRON-	PRP
cord-260054-iihgc5nr	40	35	,	,	,
cord-260054-iihgc5nr	40	36	S943P	S943P	NNP
cord-260054-iihgc5nr	40	37	,	,	,
cord-260054-iihgc5nr	40	38	would	would	MD
cord-260054-iihgc5nr	40	39	introduce	introduce	VB
cord-260054-iihgc5nr	40	40	unexpected	unexpected	JJ
cord-260054-iihgc5nr	40	41	structural	structural	JJ
cord-260054-iihgc5nr	40	42	strain	strain	NN
cord-260054-iihgc5nr	40	43	in	in	IN
cord-260054-iihgc5nr	40	44	the	the	DT
cord-260054-iihgc5nr	40	45	pre	pre	JJ
cord-260054-iihgc5nr	40	46	-	-	JJ
cord-260054-iihgc5nr	40	47	fusion	fusion	JJ
cord-260054-iihgc5nr	40	48	conformation	conformation	NN
cord-260054-iihgc5nr	40	49	.	.	.
cord-260054-iihgc5nr	41	1	A	a	DT
cord-260054-iihgc5nr	41	2	search	search	NN
cord-260054-iihgc5nr	41	3	in	in	IN
cord-260054-iihgc5nr	41	4	the	the	DT
cord-260054-iihgc5nr	41	5	GISAID	GISAID	NNP
cord-260054-iihgc5nr	41	6	resource	resource	NN
cord-260054-iihgc5nr	41	7	updated	update	VBN
cord-260054-iihgc5nr	41	8	to	to	IN
cord-260054-iihgc5nr	41	9	May	May	NNP
cord-260054-iihgc5nr	41	10	29	29	CD
cord-260054-iihgc5nr	41	11	th	th	XX
cord-260054-iihgc5nr	41	12	showed	show	VBD
cord-260054-iihgc5nr	41	13	a	a	DT
cord-260054-iihgc5nr	41	14	significant	significant	JJ
cord-260054-iihgc5nr	41	15	increase	increase	NN
cord-260054-iihgc5nr	41	16	in	in	IN
cord-260054-iihgc5nr	41	17	occurrences	occurrence	NNS
cord-260054-iihgc5nr	41	18	especially	especially	RB
cord-260054-iihgc5nr	41	19	for	for	IN
cord-260054-iihgc5nr	41	20	one	one	CD
cord-260054-iihgc5nr	41	21	mutant	mutant	NN
cord-260054-iihgc5nr	41	22	,	,	,
cord-260054-iihgc5nr	41	23	D936Y	D936Y	NNP
cord-260054-iihgc5nr	41	24	,	,	,
cord-260054-iihgc5nr	41	25	unreported	unreported	JJ
cord-260054-iihgc5nr	41	26	to	to	IN
cord-260054-iihgc5nr	41	27	date	date	NN
cord-260054-iihgc5nr	41	28	,	,	,
cord-260054-iihgc5nr	41	29	which	which	WDT
cord-260054-iihgc5nr	41	30	has	have	VBZ
cord-260054-iihgc5nr	41	31	become	become	VBN
cord-260054-iihgc5nr	41	32	a	a	DT
cord-260054-iihgc5nr	41	33	common	common	JJ
cord-260054-iihgc5nr	41	34	variant	variant	NN
cord-260054-iihgc5nr	41	35	in	in	IN
cord-260054-iihgc5nr	41	36	some	some	DT
cord-260054-iihgc5nr	41	37	European	european	JJ
cord-260054-iihgc5nr	41	38	countries	country	NNS
cord-260054-iihgc5nr	41	39	,	,	,
cord-260054-iihgc5nr	41	40	especially	especially	RB
cord-260054-iihgc5nr	41	41	Sweden	Sweden	NNP
cord-260054-iihgc5nr	41	42	.	.	.
cord-260054-iihgc5nr	42	1	It	-PRON-	PRP
cord-260054-iihgc5nr	42	2	is	be	VBZ
cord-260054-iihgc5nr	42	3	also	also	RB
cord-260054-iihgc5nr	42	4	the	the	DT
cord-260054-iihgc5nr	42	5	mutant	mutant	NN
cord-260054-iihgc5nr	42	6	having	have	VBG
cord-260054-iihgc5nr	42	7	the	the	DT
cord-260054-iihgc5nr	42	8	most	most	RBS
cord-260054-iihgc5nr	42	9	significant	significant	JJ
cord-260054-iihgc5nr	42	10	structural	structural	JJ
cord-260054-iihgc5nr	42	11	role	role	NN
cord-260054-iihgc5nr	42	12	,	,	,
cord-260054-iihgc5nr	42	13	causing	cause	VBG
cord-260054-iihgc5nr	42	14	the	the	DT
cord-260054-iihgc5nr	42	15	loss	loss	NN
cord-260054-iihgc5nr	42	16	of	of	IN
cord-260054-iihgc5nr	42	17	an	an	DT
cord-260054-iihgc5nr	42	18	intermonomer	intermonomer	NNP
cord-260054-iihgc5nr	42	19	salt	salt	NN
cord-260054-iihgc5nr	42	20	bridge	bridge	NN
cord-260054-iihgc5nr	42	21	in	in	IN
cord-260054-iihgc5nr	42	22	the	the	DT
cord-260054-iihgc5nr	42	23	post	post	JJ
cord-260054-iihgc5nr	42	24	-	-	JJ
cord-260054-iihgc5nr	42	25	fusion	fusion	JJ
cord-260054-iihgc5nr	42	26	assembly	assembly	NN
cord-260054-iihgc5nr	42	27	.	.	.
cord-260054-iihgc5nr	43	1	We	-PRON-	PRP
cord-260054-iihgc5nr	43	2	downloaded	download	VBD
cord-260054-iihgc5nr	43	3	the	the	DT
cord-260054-iihgc5nr	43	4	10,823	10,823	CD
cord-260054-iihgc5nr	43	5	genomic	genomic	JJ
cord-260054-iihgc5nr	43	6	sequences	sequence	NNS
cord-260054-iihgc5nr	43	7	available	available	JJ
cord-260054-iihgc5nr	43	8	from	from	IN
cord-260054-iihgc5nr	43	9	GISAID	GISAID	NNP
cord-260054-iihgc5nr	43	10	on	on	IN
cord-260054-iihgc5nr	43	11	April	April	NNP
cord-260054-iihgc5nr	43	12	21	21	CD
cord-260054-iihgc5nr	44	1	st	st	NNP
cord-260054-iihgc5nr	44	2	2020	2020	CD
cord-260054-iihgc5nr	44	3	.	.	.
cord-260054-iihgc5nr	45	1	From	from	IN
cord-260054-iihgc5nr	45	2	these	these	DT
cord-260054-iihgc5nr	45	3	sequences	sequence	NNS
cord-260054-iihgc5nr	45	4	,	,	,
cord-260054-iihgc5nr	45	5	we	-PRON-	PRP
cord-260054-iihgc5nr	45	6	extracted	extract	VBD
cord-260054-iihgc5nr	45	7	the	the	DT
cord-260054-iihgc5nr	45	8	nucleotide	nucleotide	JJ
cord-260054-iihgc5nr	45	9	sequences	sequence	NNS
cord-260054-iihgc5nr	45	10	of	of	IN
cord-260054-iihgc5nr	45	11	the	the	DT
cord-260054-iihgc5nr	45	12	spike	spike	NN
cord-260054-iihgc5nr	45	13	protein	protein	NN
cord-260054-iihgc5nr	45	14	and	and	CC
cord-260054-iihgc5nr	45	15	translated	translate	VBD
cord-260054-iihgc5nr	45	16	them	-PRON-	PRP
cord-260054-iihgc5nr	45	17	to	to	IN
cord-260054-iihgc5nr	45	18	protein	protein	NN
cord-260054-iihgc5nr	45	19	sequences	sequence	NNS
cord-260054-iihgc5nr	45	20	with	with	IN
cord-260054-iihgc5nr	45	21	in	in	IN
cord-260054-iihgc5nr	45	22	-	-	HYPH
cord-260054-iihgc5nr	45	23	house	house	NN
cord-260054-iihgc5nr	45	24	scripts	script	NNS
cord-260054-iihgc5nr	45	25	.	.	.
cord-260054-iihgc5nr	46	1	Nucleotides	nucleotide	NNS
cord-260054-iihgc5nr	46	2	sequences	sequence	NNS
cord-260054-iihgc5nr	46	3	featuring	feature	VBG
cord-260054-iihgc5nr	46	4	an	an	DT
cord-260054-iihgc5nr	46	5	internal	internal	JJ
cord-260054-iihgc5nr	46	6	stop	stop	NN
cord-260054-iihgc5nr	46	7	codon	codon	NN
cord-260054-iihgc5nr	46	8	,	,	,
cord-260054-iihgc5nr	46	9	having	have	VBG
cord-260054-iihgc5nr	46	10	at	at	RB
cord-260054-iihgc5nr	46	11	least	least	RBS
cord-260054-iihgc5nr	46	12	one	one	CD
cord-260054-iihgc5nr	46	13	undefined	undefined	JJ
cord-260054-iihgc5nr	46	14	(	(	-LRB-
cord-260054-iihgc5nr	46	15	"	"	``
cord-260054-iihgc5nr	46	16	N	N	NNP
cord-260054-iihgc5nr	46	17	"	"	''
cord-260054-iihgc5nr	46	18	)	)	-RRB-
cord-260054-iihgc5nr	46	19	nucleotide	nucleotide	JJ
cord-260054-iihgc5nr	46	20	or	or	CC
cord-260054-iihgc5nr	46	21	resulting	result	VBG
cord-260054-iihgc5nr	46	22	in	in	IN
cord-260054-iihgc5nr	46	23	spike	spike	NN
cord-260054-iihgc5nr	46	24	proteins	protein	NNS
cord-260054-iihgc5nr	46	25	of	of	IN
cord-260054-iihgc5nr	46	26	length	length	NN
cord-260054-iihgc5nr	46	27	different	different	JJ
cord-260054-iihgc5nr	46	28	from	from	IN
cord-260054-iihgc5nr	46	29	1,273	1,273	CD
cord-260054-iihgc5nr	46	30	amino	amino	JJ
cord-260054-iihgc5nr	46	31	acids	acid	NNS
cord-260054-iihgc5nr	46	32	were	be	VBD
cord-260054-iihgc5nr	46	33	discarded	discard	VBN
cord-260054-iihgc5nr	46	34	.	.	.
cord-260054-iihgc5nr	47	1	Sequences	sequence	NNS
cord-260054-iihgc5nr	47	2	annotated	annotate	VBN
cord-260054-iihgc5nr	47	3	as	as	IN
cord-260054-iihgc5nr	47	4	pangolin	pangolin	NN
cord-260054-iihgc5nr	47	5	,	,	,
cord-260054-iihgc5nr	47	6	bat	bat	NN
cord-260054-iihgc5nr	47	7	or	or	CC
cord-260054-iihgc5nr	47	8	canine	canine	NN
cord-260054-iihgc5nr	47	9	were	be	VBD
cord-260054-iihgc5nr	47	10	also	also	RB
cord-260054-iihgc5nr	47	11	discarded	discard	VBN
cord-260054-iihgc5nr	47	12	.	.	.
cord-260054-iihgc5nr	48	1	The	the	DT
cord-260054-iihgc5nr	48	2	remaining	remain	VBG
cord-260054-iihgc5nr	48	3	7,692	7,692	CD
cord-260054-iihgc5nr	48	4	protein	protein	NN
cord-260054-iihgc5nr	48	5	sequences	sequence	NNS
cord-260054-iihgc5nr	48	6	were	be	VBD
cord-260054-iihgc5nr	48	7	further	further	RB
cord-260054-iihgc5nr	48	8	analysed	analyse	VBN
cord-260054-iihgc5nr	48	9	.	.	.
cord-260054-iihgc5nr	49	1	First	first	RB
cord-260054-iihgc5nr	49	2	,	,	,
cord-260054-iihgc5nr	49	3	we	-PRON-	PRP
cord-260054-iihgc5nr	49	4	clustered	cluster	VBD
cord-260054-iihgc5nr	49	5	them	-PRON-	PRP
cord-260054-iihgc5nr	49	6	in	in	IN
cord-260054-iihgc5nr	49	7	sets	set	NNS
cord-260054-iihgc5nr	49	8	of	of	IN
cord-260054-iihgc5nr	49	9	identical	identical	JJ
cord-260054-iihgc5nr	49	10	sequences	sequence	NNS
cord-260054-iihgc5nr	49	11	with	with	IN
cord-260054-iihgc5nr	49	12	CD	CD	NNP
cord-260054-iihgc5nr	49	13	-	-	HYPH
cord-260054-iihgc5nr	49	14	HIT	HIT	NNP
cord-260054-iihgc5nr	49	15	(	(	-LRB-
cord-260054-iihgc5nr	49	16	32	32	CD
cord-260054-iihgc5nr	49	17	)	)	-RRB-
cord-260054-iihgc5nr	49	18	,	,	,
cord-260054-iihgc5nr	49	19	obtaining	obtain	VBG
cord-260054-iihgc5nr	49	20	120	120	CD
cord-260054-iihgc5nr	49	21	clusters	cluster	NNS
cord-260054-iihgc5nr	49	22	of	of	IN
cord-260054-iihgc5nr	49	23	at	at	RB
cord-260054-iihgc5nr	49	24	least	least	JJS
cord-260054-iihgc5nr	49	25	2	2	CD
cord-260054-iihgc5nr	49	26	sequences	sequence	NNS
cord-260054-iihgc5nr	49	27	and	and	CC
cord-260054-iihgc5nr	49	28	245	245	CD
cord-260054-iihgc5nr	49	29	unique	unique	JJ
cord-260054-iihgc5nr	49	30	sequences	sequence	NNS
cord-260054-iihgc5nr	49	31	.	.	.
cord-260054-iihgc5nr	50	1	As	as	IN
cord-260054-iihgc5nr	50	2	a	a	DT
cord-260054-iihgc5nr	50	3	reference	reference	NN
cord-260054-iihgc5nr	50	4	system	system	NN
cord-260054-iihgc5nr	50	5	for	for	IN
cord-260054-iihgc5nr	50	6	further	further	JJ
cord-260054-iihgc5nr	50	7	analyses	analysis	NNS
cord-260054-iihgc5nr	50	8	,	,	,
cord-260054-iihgc5nr	50	9	we	-PRON-	PRP
cord-260054-iihgc5nr	50	10	used	use	VBD
cord-260054-iihgc5nr	50	11	the	the	DT
cord-260054-iihgc5nr	50	12	first	first	JJ
cord-260054-iihgc5nr	50	13	dated	date	VBN
cord-260054-iihgc5nr	50	14	(	(	-LRB-
cord-260054-iihgc5nr	50	15	on	on	IN
cord-260054-iihgc5nr	50	16	December	December	NNP
cord-260054-iihgc5nr	50	17	24	24	CD
cord-260054-iihgc5nr	50	18	th	th	CD
cord-260054-iihgc5nr	50	19	2019	2019	CD
cord-260054-iihgc5nr	50	20	)	)	-RRB-
cord-260054-iihgc5nr	51	1	genomic	genomic	JJ
cord-260054-iihgc5nr	51	2	sequence	sequence	NN
cord-260054-iihgc5nr	51	3	in	in	IN
cord-260054-iihgc5nr	51	4	GISAID	GISAID	NNP
cord-260054-iihgc5nr	51	5	,	,	,
cord-260054-iihgc5nr	52	1	isolated	isolate	VBN
cord-260054-iihgc5nr	52	2	and	and	CC
cord-260054-iihgc5nr	52	3	sequenced	sequence	VBN
cord-260054-iihgc5nr	52	4	in	in	IN
cord-260054-iihgc5nr	52	5	Wuhan	Wuhan	NNP
cord-260054-iihgc5nr	52	6	(	(	-LRB-
cord-260054-iihgc5nr	52	7	Hubei	Hubei	NNP
cord-260054-iihgc5nr	52	8	,	,	,
cord-260054-iihgc5nr	52	9	China	China	NNP
cord-260054-iihgc5nr	52	10	)	)	-RRB-
cord-260054-iihgc5nr	52	11	(	(	-LRB-
cord-260054-iihgc5nr	52	12	30	30	CD
cord-260054-iihgc5nr	52	13	)	)	-RRB-
cord-260054-iihgc5nr	52	14	.	.	.
cord-260054-iihgc5nr	53	1	Then	then	RB
cord-260054-iihgc5nr	53	2	,	,	,
cord-260054-iihgc5nr	53	3	upon	upon	IN
cord-260054-iihgc5nr	53	4	alignment	alignment	NN
cord-260054-iihgc5nr	53	5	to	to	IN
cord-260054-iihgc5nr	53	6	the	the	DT
cord-260054-iihgc5nr	53	7	reference	reference	NN
cord-260054-iihgc5nr	53	8	sequence	sequence	NN
cord-260054-iihgc5nr	53	9	,	,	,
cord-260054-iihgc5nr	53	10	we	-PRON-	PRP
cord-260054-iihgc5nr	53	11	identified	identify	VBD
cord-260054-iihgc5nr	53	12	point	point	NN
cord-260054-iihgc5nr	53	13	mutations	mutation	NNS
cord-260054-iihgc5nr	53	14	in	in	IN
cord-260054-iihgc5nr	53	15	all	all	PDT
cord-260054-iihgc5nr	53	16	the	the	DT
cord-260054-iihgc5nr	53	17	sets	set	NNS
cord-260054-iihgc5nr	53	18	of	of	IN
cord-260054-iihgc5nr	53	19	at	at	RB
cord-260054-iihgc5nr	53	20	least	least	RBS
cord-260054-iihgc5nr	53	21	two	two	CD
cord-260054-iihgc5nr	53	22	sequences	sequence	NNS
cord-260054-iihgc5nr	53	23	.	.	.
cord-260054-iihgc5nr	54	1	We	-PRON-	PRP
cord-260054-iihgc5nr	54	2	downloaded	download	VBD
cord-260054-iihgc5nr	54	3	again	again	RB
cord-260054-iihgc5nr	54	4	the	the	DT
cord-260054-iihgc5nr	54	5	34,805	34,805	CD
cord-260054-iihgc5nr	54	6	genomic	genomic	JJ
cord-260054-iihgc5nr	54	7	sequences	sequence	NNS
cord-260054-iihgc5nr	54	8	available	available	JJ
cord-260054-iihgc5nr	54	9	from	from	IN
cord-260054-iihgc5nr	54	10	GISAID	GISAID	NNP
cord-260054-iihgc5nr	54	11	on	on	IN
cord-260054-iihgc5nr	54	12	May	May	NNP
cord-260054-iihgc5nr	54	13	29	29	CD
cord-260054-iihgc5nr	54	14	th	th	CD
cord-260054-iihgc5nr	54	15	2020	2020	CD
cord-260054-iihgc5nr	54	16	(	(	-LRB-
cord-260054-iihgc5nr	54	17	gisaid_hcov-19_2020_05_29_14	gisaid_hcov-19_2020_05_29_14	NNP
cord-260054-iihgc5nr	54	18	)	)	-RRB-
cord-260054-iihgc5nr	54	19	and	and	CC
cord-260054-iihgc5nr	54	20	followed	follow	VBD
cord-260054-iihgc5nr	54	21	the	the	DT
cord-260054-iihgc5nr	54	22	above	above	JJ
cord-260054-iihgc5nr	54	23	pipeline	pipeline	NN
cord-260054-iihgc5nr	54	24	to	to	TO
cord-260054-iihgc5nr	54	25	extract	extract	VB
cord-260054-iihgc5nr	54	26	23,332	23,332	CD
cord-260054-iihgc5nr	54	27	complete	complete	JJ
cord-260054-iihgc5nr	54	28	1273-residue	1273-residue	CD
cord-260054-iihgc5nr	54	29	long	long	JJ
cord-260054-iihgc5nr	54	30	S	s	NN
cord-260054-iihgc5nr	54	31	protein	protein	NN
cord-260054-iihgc5nr	54	32	sequences	sequence	NNS
cord-260054-iihgc5nr	54	33	.	.	.
cord-260054-iihgc5nr	55	1	We	-PRON-	PRP
cord-260054-iihgc5nr	55	2	then	then	RB
cord-260054-iihgc5nr	55	3	recorded	record	VBD
cord-260054-iihgc5nr	55	4	the	the	DT
cord-260054-iihgc5nr	55	5	presence	presence	NN
cord-260054-iihgc5nr	55	6	and	and	CC
cord-260054-iihgc5nr	55	7	frequency	frequency	NN
cord-260054-iihgc5nr	55	8	in	in	IN
cord-260054-iihgc5nr	55	9	them	-PRON-	PRP
cord-260054-iihgc5nr	55	10	of	of	IN
cord-260054-iihgc5nr	55	11	any	any	DT
cord-260054-iihgc5nr	55	12	mutation	mutation	NN
cord-260054-iihgc5nr	55	13	occurring	occur	VBG
cord-260054-iihgc5nr	55	14	in	in	IN
cord-260054-iihgc5nr	55	15	the	the	DT
cord-260054-iihgc5nr	55	16	fusion	fusion	NN
cord-260054-iihgc5nr	55	17	core	core	NN
cord-260054-iihgc5nr	55	18	of	of	IN
cord-260054-iihgc5nr	55	19	the	the	DT
cord-260054-iihgc5nr	55	20	HR1	HR1	NNP
cord-260054-iihgc5nr	55	21	(	(	-LRB-
cord-260054-iihgc5nr	55	22	residues	residue	NNS
cord-260054-iihgc5nr	55	23	929	929	CD
cord-260054-iihgc5nr	55	24	-	-	SYM
cord-260054-iihgc5nr	55	25	949	949	CD
cord-260054-iihgc5nr	55	26	)	)	-RRB-
cord-260054-iihgc5nr	55	27	with	with	IN
cord-260054-iihgc5nr	55	28	in	in	IN
cord-260054-iihgc5nr	55	29	-	-	HYPH
cord-260054-iihgc5nr	55	30	house	house	NN
cord-260054-iihgc5nr	55	31	scripts	script	NNS
cord-260054-iihgc5nr	55	32	.	.	.
cord-260054-iihgc5nr	56	1	Mutants	mutant	NNS
cord-260054-iihgc5nr	56	2	3D	3d	JJ
cord-260054-iihgc5nr	56	3	models	model	NNS
cord-260054-iihgc5nr	56	4	were	be	VBD
cord-260054-iihgc5nr	56	5	built	build	VBN
cord-260054-iihgc5nr	56	6	using	use	VBG
cord-260054-iihgc5nr	56	7	the	the	DT
cord-260054-iihgc5nr	56	8	mutate_model	mutate_model	NNP
cord-260054-iihgc5nr	56	9	module	module	NN
cord-260054-iihgc5nr	56	10	of	of	IN
cord-260054-iihgc5nr	56	11	the	the	DT
cord-260054-iihgc5nr	56	12	Modeller	Modeller	NNP
cord-260054-iihgc5nr	56	13	9v11	9v11	CD
cord-260054-iihgc5nr	56	14	program	program	NN
cord-260054-iihgc5nr	56	15	(	(	-LRB-
cord-260054-iihgc5nr	56	16	33	33	CD
cord-260054-iihgc5nr	56	17	)	)	-RRB-
cord-260054-iihgc5nr	56	18	.	.	.
cord-260054-iihgc5nr	57	1	This	this	DT
cord-260054-iihgc5nr	57	2	is	be	VBZ
cord-260054-iihgc5nr	57	3	an	an	DT
cord-260054-iihgc5nr	57	4	automated	automated	JJ
cord-260054-iihgc5nr	57	5	method	method	NN
cord-260054-iihgc5nr	57	6	for	for	IN
cord-260054-iihgc5nr	57	7	modelling	modelling	NN
cord-260054-iihgc5nr	57	8	point	point	NN
cord-260054-iihgc5nr	57	9	mutations	mutation	NNS
cord-260054-iihgc5nr	57	10	in	in	IN
cord-260054-iihgc5nr	57	11	protein	protein	NN
cord-260054-iihgc5nr	57	12	structures	structure	NNS
cord-260054-iihgc5nr	57	13	,	,	,
cord-260054-iihgc5nr	57	14	which	which	WDT
cord-260054-iihgc5nr	57	15	includes	include	VBZ
cord-260054-iihgc5nr	57	16	an	an	DT
cord-260054-iihgc5nr	57	17	optimisation	optimisation	NN
cord-260054-iihgc5nr	57	18	procedure	procedure	NN
cord-260054-iihgc5nr	57	19	of	of	IN
cord-260054-iihgc5nr	57	20	the	the	DT
cord-260054-iihgc5nr	57	21	mutated	mutated	JJ
cord-260054-iihgc5nr	57	22	residue	residue	NN
cord-260054-iihgc5nr	57	23	in	in	IN
cord-260054-iihgc5nr	57	24	its	-PRON-	PRP$
cord-260054-iihgc5nr	57	25	environment	environment	NN
cord-260054-iihgc5nr	57	26	,	,	,
cord-260054-iihgc5nr	57	27	beginning	begin	VBG
cord-260054-iihgc5nr	57	28	with	with	IN
cord-260054-iihgc5nr	57	29	a	a	DT
cord-260054-iihgc5nr	57	30	conjugate	conjugate	NN
cord-260054-iihgc5nr	57	31	gradients	gradient	NNS
cord-260054-iihgc5nr	57	32	minimisation	minimisation	NN
cord-260054-iihgc5nr	57	33	,	,	,
cord-260054-iihgc5nr	57	34	continuing	continue	VBG
cord-260054-iihgc5nr	57	35	with	with	IN
cord-260054-iihgc5nr	57	36	molecular	molecular	JJ
cord-260054-iihgc5nr	57	37	dynamics	dynamic	NNS
cord-260054-iihgc5nr	57	38	with	with	IN
cord-260054-iihgc5nr	57	39	simulated	simulated	JJ
cord-260054-iihgc5nr	57	40	annealing	annealing	NN
cord-260054-iihgc5nr	57	41	and	and	CC
cord-260054-iihgc5nr	57	42	finishing	finish	VBG
cord-260054-iihgc5nr	57	43	again	again	RB
cord-260054-iihgc5nr	57	44	by	by	IN
cord-260054-iihgc5nr	57	45	conjugate	conjugate	NN
cord-260054-iihgc5nr	57	46	gradients	gradient	NNS
cord-260054-iihgc5nr	57	47	.	.	.
cord-260054-iihgc5nr	58	1	The	the	DT
cord-260054-iihgc5nr	58	2	used	use	VBN
cord-260054-iihgc5nr	58	3	force	force	NN
cord-260054-iihgc5nr	58	4	field	field	NN
cord-260054-iihgc5nr	58	5	is	be	VBZ
cord-260054-iihgc5nr	58	6	CHARM-22	charm-22	NN
cord-260054-iihgc5nr	58	7	,	,	,
cord-260054-iihgc5nr	58	8	for	for	IN
cord-260054-iihgc5nr	58	9	details	detail	NNS
cord-260054-iihgc5nr	58	10	see	see	VBP
cord-260054-iihgc5nr	58	11	Reference	reference	NN
cord-260054-iihgc5nr	58	12	(	(	-LRB-
cord-260054-iihgc5nr	58	13	34	34	CD
cord-260054-iihgc5nr	58	14	)	)	-RRB-
cord-260054-iihgc5nr	58	15	.	.	.
cord-260054-iihgc5nr	59	1	Models	model	NNS
cord-260054-iihgc5nr	59	2	for	for	IN
cord-260054-iihgc5nr	59	3	mutants	mutant	NNS
cord-260054-iihgc5nr	59	4	in	in	IN
cord-260054-iihgc5nr	59	5	the	the	DT
cord-260054-iihgc5nr	59	6	pre	pre	JJ
cord-260054-iihgc5nr	59	7	-	-	JJ
cord-260054-iihgc5nr	59	8	fusion	fusion	JJ
cord-260054-iihgc5nr	59	9	conformation	conformation	NN
cord-260054-iihgc5nr	59	10	were	be	VBD
cord-260054-iihgc5nr	59	11	built	build	VBN
cord-260054-iihgc5nr	59	12	starting	start	VBG
cord-260054-iihgc5nr	59	13	from	from	IN
cord-260054-iihgc5nr	59	14	the	the	DT
cord-260054-iihgc5nr	59	15	EM	EM	NNP
cord-260054-iihgc5nr	59	16	structure	structure	NN
cord-260054-iihgc5nr	59	17	of	of	IN
cord-260054-iihgc5nr	59	18	the	the	DT
cord-260054-iihgc5nr	59	19	pre	pre	JJ
cord-260054-iihgc5nr	59	20	-	-	JJ
cord-260054-iihgc5nr	59	21	fusion	fusion	JJ
cord-260054-iihgc5nr	59	22	trimeric	trimeric	JJ
cord-260054-iihgc5nr	59	23	conformation	conformation	NN
cord-260054-iihgc5nr	59	24	(	(	-LRB-
cord-260054-iihgc5nr	59	25	PDB	PDB	NNP
cord-260054-iihgc5nr	59	26	ID	ID	NNP
cord-260054-iihgc5nr	59	27	:	:	:
cord-260054-iihgc5nr	59	28	6VSB	6VSB	NNP
cord-260054-iihgc5nr	59	29	,	,	,
cord-260054-iihgc5nr	59	30	resolution	resolution	NN
cord-260054-iihgc5nr	59	31	3.46	3.46	CD
cord-260054-iihgc5nr	59	32	Å	å	NN
cord-260054-iihgc5nr	59	33	,	,	,
cord-260054-iihgc5nr	59	34	(	(	-LRB-
cord-260054-iihgc5nr	59	35	22	22	CD
cord-260054-iihgc5nr	59	36	)	)	-RRB-
cord-260054-iihgc5nr	59	37	)	)	-RRB-
cord-260054-iihgc5nr	59	38	.	.	.
cord-260054-iihgc5nr	60	1	Models	model	NNS
cord-260054-iihgc5nr	60	2	for	for	IN
cord-260054-iihgc5nr	60	3	mutants	mutant	NNS
cord-260054-iihgc5nr	60	4	in	in	IN
cord-260054-iihgc5nr	60	5	the	the	DT
cord-260054-iihgc5nr	60	6	post	post	JJ
cord-260054-iihgc5nr	60	7	-	-	JJ
cord-260054-iihgc5nr	60	8	fusion	fusion	JJ
cord-260054-iihgc5nr	60	9	conformation	conformation	NN
cord-260054-iihgc5nr	60	10	were	be	VBD
cord-260054-iihgc5nr	60	11	built	build	VBN
cord-260054-iihgc5nr	60	12	starting	start	VBG
cord-260054-iihgc5nr	60	13	from	from	IN
cord-260054-iihgc5nr	60	14	the	the	DT
cord-260054-iihgc5nr	60	15	X	x	NN
cord-260054-iihgc5nr	60	16	-	-	NN
cord-260054-iihgc5nr	60	17	ray	ray	JJ
cord-260054-iihgc5nr	60	18	structure	structure	NN
cord-260054-iihgc5nr	60	19	of	of	IN
cord-260054-iihgc5nr	60	20	the	the	DT
cord-260054-iihgc5nr	60	21	S2	S2	NNP
cord-260054-iihgc5nr	60	22	subunit	subunit	NN
cord-260054-iihgc5nr	60	23	fusion	fusion	NN
cord-260054-iihgc5nr	60	24	core	core	NN
cord-260054-iihgc5nr	60	25	(	(	-LRB-
cord-260054-iihgc5nr	60	26	PDB	PDB	NNP
cord-260054-iihgc5nr	60	27	ID	ID	NNP
cord-260054-iihgc5nr	60	28	:	:	:
cord-260054-iihgc5nr	60	29	6LXT	6LXT	NNP
cord-260054-iihgc5nr	60	30	,	,	,
cord-260054-iihgc5nr	60	31	resolution	resolution	NN
cord-260054-iihgc5nr	60	32	2.90	2.90	CD
cord-260054-iihgc5nr	60	33	Å	å	NN
cord-260054-iihgc5nr	60	34	,	,	,
cord-260054-iihgc5nr	60	35	(	(	-LRB-
cord-260054-iihgc5nr	60	36	29	29	CD
cord-260054-iihgc5nr	60	37	)	)	-RRB-
cord-260054-iihgc5nr	60	38	)	)	-RRB-
cord-260054-iihgc5nr	60	39	.	.	.
cord-260054-iihgc5nr	61	1	Molecular	molecular	JJ
cord-260054-iihgc5nr	61	2	models	model	NNS
cord-260054-iihgc5nr	61	3	were	be	VBD
cord-260054-iihgc5nr	61	4	analysed	analyse	VBN
cord-260054-iihgc5nr	61	5	and	and	CC
cord-260054-iihgc5nr	61	6	visually	visually	RB
cord-260054-iihgc5nr	61	7	inspected	inspect	VBN
cord-260054-iihgc5nr	61	8	with	with	IN
cord-260054-iihgc5nr	61	9	Pymol	Pymol	NNP
cord-260054-iihgc5nr	61	10	(	(	-LRB-
cord-260054-iihgc5nr	61	11	35	35	CD
cord-260054-iihgc5nr	61	12	)	)	-RRB-
cord-260054-iihgc5nr	61	13	.	.	.
cord-260054-iihgc5nr	62	1	The	the	DT
cord-260054-iihgc5nr	62	2	COCOMAPS	COCOMAPS	NNP
cord-260054-iihgc5nr	62	3	web	web	NN
cord-260054-iihgc5nr	62	4	server	server	NN
cord-260054-iihgc5nr	62	5	(	(	-LRB-
cord-260054-iihgc5nr	62	6	36	36	CD
cord-260054-iihgc5nr	62	7	)	)	-RRB-
cord-260054-iihgc5nr	62	8	was	be	VBD
cord-260054-iihgc5nr	62	9	used	use	VBN
cord-260054-iihgc5nr	62	10	to	to	TO
cord-260054-iihgc5nr	62	11	analyse	analyse	VB
cord-260054-iihgc5nr	62	12	the	the	DT
cord-260054-iihgc5nr	62	13	inter	inter	JJ
cord-260054-iihgc5nr	62	14	-	-	JJ
cord-260054-iihgc5nr	62	15	chain	chain	JJ
cord-260054-iihgc5nr	62	16	contacts	contact	NNS
cord-260054-iihgc5nr	62	17	and	and	CC
cord-260054-iihgc5nr	62	18	Hbonds	Hbonds	NNPS
cord-260054-iihgc5nr	62	19	as	as	RB
cord-260054-iihgc5nr	62	20	well	well	RB
cord-260054-iihgc5nr	62	21	as	as	IN
cord-260054-iihgc5nr	62	22	the	the	DT
cord-260054-iihgc5nr	62	23	residues	residue	NNS
cord-260054-iihgc5nr	62	24	accessibility	accessibility	NN
cord-260054-iihgc5nr	62	25	to	to	IN
cord-260054-iihgc5nr	62	26	the	the	DT
cord-260054-iihgc5nr	62	27	solvent	solvent	NN
cord-260054-iihgc5nr	62	28	.	.	.
cord-260054-iihgc5nr	63	1	We	-PRON-	PRP
cord-260054-iihgc5nr	63	2	downloaded	download	VBD
cord-260054-iihgc5nr	63	3	all	all	PDT
cord-260054-iihgc5nr	63	4	the	the	DT
cord-260054-iihgc5nr	63	5	SARS	SARS	NNP
cord-260054-iihgc5nr	63	6	-	-	HYPH
cord-260054-iihgc5nr	63	7	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	63	8	genomic	genomic	JJ
cord-260054-iihgc5nr	63	9	sequences	sequence	NNS
cord-260054-iihgc5nr	63	10	from	from	IN
cord-260054-iihgc5nr	63	11	the	the	DT
cord-260054-iihgc5nr	63	12	GISAID	GISAID	NNP
cord-260054-iihgc5nr	63	13	resource	resource	NN
cord-260054-iihgc5nr	63	14	on	on	IN
cord-260054-iihgc5nr	63	15	April	April	NNP
cord-260054-iihgc5nr	63	16	21	21	CD
cord-260054-iihgc5nr	63	17	st	st	NNP
cord-260054-iihgc5nr	63	18	2020	2020	CD
cord-260054-iihgc5nr	63	19	,	,	,
cord-260054-iihgc5nr	63	20	extracted	extract	VBN
cord-260054-iihgc5nr	63	21	from	from	IN
cord-260054-iihgc5nr	63	22	them	-PRON-	PRP
cord-260054-iihgc5nr	63	23	7,692	7,692	CD
cord-260054-iihgc5nr	63	24	complete	complete	JJ
cord-260054-iihgc5nr	63	25	S	S	NNP
cord-260054-iihgc5nr	63	26	protein	protein	NN
cord-260054-iihgc5nr	63	27	sequences	sequence	NNS
cord-260054-iihgc5nr	63	28	and	and	CC
cord-260054-iihgc5nr	63	29	identified	identify	VBD
cord-260054-iihgc5nr	63	30	all	all	PDT
cord-260054-iihgc5nr	63	31	the	the	DT
cord-260054-iihgc5nr	63	32	point	point	NN
cord-260054-iihgc5nr	63	33	mutations	mutation	NNS
cord-260054-iihgc5nr	63	34	occurring	occur	VBG
cord-260054-iihgc5nr	63	35	in	in	IN
cord-260054-iihgc5nr	63	36	at	at	RB
cord-260054-iihgc5nr	63	37	least	least	RBS
cord-260054-iihgc5nr	63	38	two	two	CD
cord-260054-iihgc5nr	63	39	identical	identical	JJ
cord-260054-iihgc5nr	63	40	sequences	sequence	NNS
cord-260054-iihgc5nr	63	41	(	(	-LRB-
cord-260054-iihgc5nr	63	42	see	see	VB
cord-260054-iihgc5nr	63	43	Methods	Methods	NNPS
cord-260054-iihgc5nr	63	44	)	)	-RRB-
cord-260054-iihgc5nr	63	45	.	.	.
cord-260054-iihgc5nr	64	1	The	the	DT
cord-260054-iihgc5nr	64	2	111	111	CD
cord-260054-iihgc5nr	64	3	mutations	mutation	NNS
cord-260054-iihgc5nr	64	4	we	-PRON-	PRP
cord-260054-iihgc5nr	64	5	identified	identify	VBD
cord-260054-iihgc5nr	64	6	,	,	,
cord-260054-iihgc5nr	64	7	occurring	occur	VBG
cord-260054-iihgc5nr	64	8	at	at	IN
cord-260054-iihgc5nr	64	9	105	105	CD
cord-260054-iihgc5nr	64	10	different	different	JJ
cord-260054-iihgc5nr	64	11	positions	position	NNS
cord-260054-iihgc5nr	64	12	spread	spread	VBP
cord-260054-iihgc5nr	64	13	all	all	RB
cord-260054-iihgc5nr	64	14	over	over	IN
cord-260054-iihgc5nr	64	15	the	the	DT
cord-260054-iihgc5nr	64	16	protein	protein	NN
cord-260054-iihgc5nr	64	17	sequence	sequence	NN
cord-260054-iihgc5nr	64	18	,	,	,
cord-260054-iihgc5nr	64	19	are	be	VBP
cord-260054-iihgc5nr	64	20	reported	report	VBN
cord-260054-iihgc5nr	64	21	in	in	IN
cord-260054-iihgc5nr	64	22	Table	Table	NNP
cord-260054-iihgc5nr	64	23	S1	S1	NNP
cord-260054-iihgc5nr	64	24	,	,	,
cord-260054-iihgc5nr	64	25	with	with	IN
cord-260054-iihgc5nr	64	26	the	the	DT
cord-260054-iihgc5nr	64	27	relative	relative	JJ
cord-260054-iihgc5nr	64	28	number	number	NN
cord-260054-iihgc5nr	64	29	of	of	IN
cord-260054-iihgc5nr	64	30	occurrences	occurrence	NNS
cord-260054-iihgc5nr	64	31	.	.	.
cord-260054-iihgc5nr	65	1	While	while	IN
cord-260054-iihgc5nr	65	2	the	the	DT
cord-260054-iihgc5nr	65	3	mutations	mutation	NNS
cord-260054-iihgc5nr	65	4	we	-PRON-	PRP
cord-260054-iihgc5nr	65	5	identified	identify	VBD
cord-260054-iihgc5nr	65	6	were	be	VBD
cord-260054-iihgc5nr	65	7	spaced	space	VBN
cord-260054-iihgc5nr	65	8	on	on	IN
cord-260054-iihgc5nr	65	9	average	average	JJ
cord-260054-iihgc5nr	65	10	12	12	CD
cord-260054-iihgc5nr	65	11	positions	position	NNS
cord-260054-iihgc5nr	65	12	along	along	IN
cord-260054-iihgc5nr	65	13	the	the	DT
cord-260054-iihgc5nr	65	14	protein	protein	NN
cord-260054-iihgc5nr	65	15	sequence	sequence	NN
cord-260054-iihgc5nr	65	16	,	,	,
cord-260054-iihgc5nr	65	17	a	a	DT
cord-260054-iihgc5nr	65	18	segment	segment	NN
cord-260054-iihgc5nr	65	19	of	of	IN
cord-260054-iihgc5nr	65	20	14	14	CD
cord-260054-iihgc5nr	65	21	amino	amino	JJ
cord-260054-iihgc5nr	65	22	acids	acid	NNS
cord-260054-iihgc5nr	65	23	harboured	harbour	VBD
cord-260054-iihgc5nr	65	24	6	6	CD
cord-260054-iihgc5nr	65	25	mutations	mutation	NNS
cord-260054-iihgc5nr	65	26	,	,	,
cord-260054-iihgc5nr	65	27	at	at	IN
cord-260054-iihgc5nr	65	28	positions	position	NNS
cord-260054-iihgc5nr	65	29	929	929	CD
cord-260054-iihgc5nr	65	30	,	,	,
cord-260054-iihgc5nr	65	31	936	936	CD
cord-260054-iihgc5nr	65	32	,	,	,
cord-260054-iihgc5nr	65	33	938	938	CD
cord-260054-iihgc5nr	65	34	,	,	,
cord-260054-iihgc5nr	65	35	939	939	CD
cord-260054-iihgc5nr	65	36	,	,	,
cord-260054-iihgc5nr	65	37	940	940	CD
cord-260054-iihgc5nr	65	38	and	and	CC
cord-260054-iihgc5nr	65	39	943	943	CD
cord-260054-iihgc5nr	65	40	,	,	,
cord-260054-iihgc5nr	65	41	proposing	propose	VBG
cord-260054-iihgc5nr	65	42	itself	-PRON-	PRP
cord-260054-iihgc5nr	65	43	as	as	IN
cord-260054-iihgc5nr	65	44	a	a	DT
cord-260054-iihgc5nr	65	45	mutational	mutational	JJ
cord-260054-iihgc5nr	65	46	hotspot	hotspot	NN
cord-260054-iihgc5nr	65	47	.	.	.
cord-260054-iihgc5nr	66	1	This	this	DT
cord-260054-iihgc5nr	66	2	sequence	sequence	NN
cord-260054-iihgc5nr	66	3	segment	segment	NN
cord-260054-iihgc5nr	66	4	is	be	VBZ
cord-260054-iihgc5nr	66	5	part	part	NN
cord-260054-iihgc5nr	66	6	of	of	IN
cord-260054-iihgc5nr	66	7	the	the	DT
cord-260054-iihgc5nr	66	8	"	"	``
cord-260054-iihgc5nr	66	9	fusion	fusion	NN
cord-260054-iihgc5nr	66	10	core	core	NN
cord-260054-iihgc5nr	66	11	"	"	''
cord-260054-iihgc5nr	66	12	of	of	IN
cord-260054-iihgc5nr	66	13	the	the	DT
cord-260054-iihgc5nr	66	14	HR1	HR1	NNP
cord-260054-iihgc5nr	66	15	,	,	,
cord-260054-iihgc5nr	66	16	in	in	IN
cord-260054-iihgc5nr	66	17	the	the	DT
cord-260054-iihgc5nr	66	18	protein	protein	NN
cord-260054-iihgc5nr	66	19	S2	S2	NNP
cord-260054-iihgc5nr	66	20	subunit	subunit	NN
cord-260054-iihgc5nr	66	21	.	.	.
cord-260054-iihgc5nr	67	1	The	the	DT
cord-260054-iihgc5nr	67	2	HR1	HR1	NNP
cord-260054-iihgc5nr	67	3	of	of	IN
cord-260054-iihgc5nr	67	4	coronaviruses	coronaviruse	NNS
cord-260054-iihgc5nr	68	1	S	s	NN
cord-260054-iihgc5nr	68	2	proteins	protein	NNS
cord-260054-iihgc5nr	68	3	undergoes	undergo	VBZ
cord-260054-iihgc5nr	68	4	one	one	CD
cord-260054-iihgc5nr	68	5	of	of	IN
cord-260054-iihgc5nr	68	6	the	the	DT
cord-260054-iihgc5nr	68	7	most	most	RBS
cord-260054-iihgc5nr	68	8	notable	notable	JJ
cord-260054-iihgc5nr	68	9	rearrangements	rearrangement	NNS
cord-260054-iihgc5nr	68	10	within	within	IN
cord-260054-iihgc5nr	68	11	the	the	DT
cord-260054-iihgc5nr	68	12	protein	protein	NN
cord-260054-iihgc5nr	68	13	between	between	IN
cord-260054-iihgc5nr	68	14	the	the	DT
cord-260054-iihgc5nr	68	15	pre	pre	NN
cord-260054-iihgc5nr	68	16	-	-	JJ
cord-260054-iihgc5nr	68	17	and	and	CC
cord-260054-iihgc5nr	68	18	post	post	JJ
cord-260054-iihgc5nr	68	19	-	-	JJ
cord-260054-iihgc5nr	68	20	fusion	fusion	JJ
cord-260054-iihgc5nr	68	21	conformations	conformation	NNS
cord-260054-iihgc5nr	68	22	.	.	.
cord-260054-iihgc5nr	69	1	In	in	IN
cord-260054-iihgc5nr	69	2	the	the	DT
cord-260054-iihgc5nr	69	3	post	post	JJ
cord-260054-iihgc5nr	69	4	-	-	JJ
cord-260054-iihgc5nr	69	5	fusion	fusion	JJ
cord-260054-iihgc5nr	69	6	conformation	conformation	NN
cord-260054-iihgc5nr	69	7	,	,	,
cord-260054-iihgc5nr	69	8	in	in	IN
cord-260054-iihgc5nr	69	9	fact	fact	NN
cord-260054-iihgc5nr	69	10	,	,	,
cord-260054-iihgc5nr	69	11	it	-PRON-	PRP
cord-260054-iihgc5nr	69	12	experiences	experience	VBZ
cord-260054-iihgc5nr	69	13	a	a	DT
cord-260054-iihgc5nr	69	14	refolding	refolding	NN
cord-260054-iihgc5nr	69	15	of	of	IN
cord-260054-iihgc5nr	69	16	the	the	DT
cord-260054-iihgc5nr	69	17	pre	pre	JJ
cord-260054-iihgc5nr	69	18	-	-	JJ
cord-260054-iihgc5nr	69	19	fusion	fusion	JJ
cord-260054-iihgc5nr	69	20	multiple	multiple	JJ
cord-260054-iihgc5nr	69	21	helices	helix	NNS
cord-260054-iihgc5nr	69	22	and	and	CC
cord-260054-iihgc5nr	69	23	intervening	intervene	VBG
cord-260054-iihgc5nr	69	24	regions	region	NNS
cord-260054-iihgc5nr	69	25	into	into	IN
cord-260054-iihgc5nr	69	26	a	a	DT
cord-260054-iihgc5nr	69	27	single	single	JJ
cord-260054-iihgc5nr	69	28	continuous	continuous	JJ
cord-260054-iihgc5nr	69	29	helix	helix	NN
cord-260054-iihgc5nr	69	30	(	(	-LRB-
cord-260054-iihgc5nr	69	31	Figure	figure	NN
cord-260054-iihgc5nr	69	32	1	1	CD
cord-260054-iihgc5nr	69	33	)	)	-RRB-
cord-260054-iihgc5nr	69	34	.	.	.
cord-260054-iihgc5nr	70	1	As	as	IN
cord-260054-iihgc5nr	70	2	already	already	RB
cord-260054-iihgc5nr	70	3	mentioned	mention	VBN
cord-260054-iihgc5nr	70	4	,	,	,
cord-260054-iihgc5nr	70	5	three	three	CD
cord-260054-iihgc5nr	70	6	of	of	IN
cord-260054-iihgc5nr	70	7	these	these	DT
cord-260054-iihgc5nr	70	8	long	long	JJ
cord-260054-iihgc5nr	70	9	helices	helix	NNS
cord-260054-iihgc5nr	70	10	then	then	RB
cord-260054-iihgc5nr	70	11	form	form	VBP
cord-260054-iihgc5nr	70	12	a	a	DT
cord-260054-iihgc5nr	70	13	6HB	6hb	CD
cord-260054-iihgc5nr	70	14	with	with	IN
cord-260054-iihgc5nr	70	15	three	three	CD
cord-260054-iihgc5nr	70	16	HR2	HR2	NNP
cord-260054-iihgc5nr	70	17	helical	helical	JJ
cord-260054-iihgc5nr	70	18	motifs	motif	NNS
cord-260054-iihgc5nr	70	19	(	(	-LRB-
cord-260054-iihgc5nr	70	20	18	18	CD
cord-260054-iihgc5nr	70	21	,	,	,
cord-260054-iihgc5nr	70	22	29	29	CD
cord-260054-iihgc5nr	70	23	,	,	,
cord-260054-iihgc5nr	70	24	31	31	CD
cord-260054-iihgc5nr	70	25	)	)	-RRB-
cord-260054-iihgc5nr	70	26	.	.	.
cord-260054-iihgc5nr	71	1	The	the	DT
cord-260054-iihgc5nr	71	2	HR1	HR1	NNP
cord-260054-iihgc5nr	71	3	and	and	CC
cord-260054-iihgc5nr	71	4	its	-PRON-	PRP$
cord-260054-iihgc5nr	71	5	"	"	``
cord-260054-iihgc5nr	71	6	fusion	fusion	NN
cord-260054-iihgc5nr	71	7	core	core	NN
cord-260054-iihgc5nr	71	8	"	"	''
cord-260054-iihgc5nr	71	9	in	in	IN
cord-260054-iihgc5nr	71	10	particular	particular	JJ
cord-260054-iihgc5nr	71	11	thus	thus	RB
cord-260054-iihgc5nr	71	12	play	play	VB
cord-260054-iihgc5nr	71	13	a	a	DT
cord-260054-iihgc5nr	71	14	crucial	crucial	JJ
cord-260054-iihgc5nr	71	15	role	role	NN
cord-260054-iihgc5nr	71	16	in	in	IN
cord-260054-iihgc5nr	71	17	the	the	DT
cord-260054-iihgc5nr	71	18	virus	virus	NN
cord-260054-iihgc5nr	71	19	infectivity	infectivity	NN
cord-260054-iihgc5nr	71	20	.	.	.
cord-260054-iihgc5nr	72	1	The	the	DT
cord-260054-iihgc5nr	72	2	following	follow	VBG
cord-260054-iihgc5nr	72	3	6	6	CD
cord-260054-iihgc5nr	72	4	mutations	mutation	NNS
cord-260054-iihgc5nr	72	5	were	be	VBD
cord-260054-iihgc5nr	72	6	identified	identify	VBN
cord-260054-iihgc5nr	72	7	in	in	IN
cord-260054-iihgc5nr	72	8	the	the	DT
cord-260054-iihgc5nr	72	9	fusion	fusion	NN
cord-260054-iihgc5nr	72	10	core	core	NN
cord-260054-iihgc5nr	72	11	of	of	IN
cord-260054-iihgc5nr	72	12	the	the	DT
cord-260054-iihgc5nr	72	13	HR1	HR1	NNP
cord-260054-iihgc5nr	72	14	on	on	IN
cord-260054-iihgc5nr	72	15	April	April	NNP
cord-260054-iihgc5nr	72	16	21	21	CD
cord-260054-iihgc5nr	72	17	st	st	NNP
cord-260054-iihgc5nr	72	18	2020	2020	CD
cord-260054-iihgc5nr	72	19	:	:	:
cord-260054-iihgc5nr	72	20	S929I	S929I	NNP
cord-260054-iihgc5nr	72	21	,	,	,
cord-260054-iihgc5nr	72	22	D936Y	D936Y	NNP
cord-260054-iihgc5nr	72	23	,	,	,
cord-260054-iihgc5nr	72	24	L938F	L938F	NNP
cord-260054-iihgc5nr	72	25	,	,	,
cord-260054-iihgc5nr	72	26	S939F	S939F	NNP
cord-260054-iihgc5nr	72	27	,	,	,
cord-260054-iihgc5nr	72	28	S940F	S940F	NNP
cord-260054-iihgc5nr	72	29	,	,	,
cord-260054-iihgc5nr	72	30	S943P.	S943P.	NNP
cord-260054-iihgc5nr	72	31	Two	two	CD
cord-260054-iihgc5nr	72	32	of	of	IN
cord-260054-iihgc5nr	72	33	these	these	DT
cord-260054-iihgc5nr	72	34	mutations	mutation	NNS
cord-260054-iihgc5nr	72	35	,	,	,
cord-260054-iihgc5nr	72	36	D936Y	D936Y	NNP
cord-260054-iihgc5nr	72	37	and	and	CC
cord-260054-iihgc5nr	72	38	S943P	S943P	NNP
cord-260054-iihgc5nr	72	39	,	,	,
cord-260054-iihgc5nr	72	40	were	be	VBD
cord-260054-iihgc5nr	72	41	among	among	IN
cord-260054-iihgc5nr	72	42	the	the	DT
cord-260054-iihgc5nr	72	43	most	most	RBS
cord-260054-iihgc5nr	72	44	frequent	frequent	JJ
cord-260054-iihgc5nr	72	45	in	in	IN
cord-260054-iihgc5nr	72	46	the	the	DT
cord-260054-iihgc5nr	72	47	ensemble	ensemble	NN
cord-260054-iihgc5nr	72	48	of	of	IN
cord-260054-iihgc5nr	72	49	mutations	mutation	NNS
cord-260054-iihgc5nr	72	50	we	-PRON-	PRP
cord-260054-iihgc5nr	72	51	identified	identify	VBD
cord-260054-iihgc5nr	72	52	.	.	.
cord-260054-iihgc5nr	73	1	Besides	besides	IN
cord-260054-iihgc5nr	73	2	the	the	DT
cord-260054-iihgc5nr	73	3	widespread	widespread	JJ
cord-260054-iihgc5nr	73	4	D614	d614	NN
cord-260054-iihgc5nr	73	5	G	g	NN
cord-260054-iihgc5nr	73	6	,	,	,
cord-260054-iihgc5nr	73	7	now	now	RB
cord-260054-iihgc5nr	73	8	dominant	dominant	JJ
cord-260054-iihgc5nr	73	9	over	over	IN
cord-260054-iihgc5nr	73	10	the	the	DT
cord-260054-iihgc5nr	73	11	original	original	JJ
cord-260054-iihgc5nr	73	12	D614	d614	NN
cord-260054-iihgc5nr	73	13	variant	variant	NN
cord-260054-iihgc5nr	73	14	(	(	-LRB-
cord-260054-iihgc5nr	73	15	37	37	CD
cord-260054-iihgc5nr	73	16	,	,	,
cord-260054-iihgc5nr	73	17	38	38	CD
cord-260054-iihgc5nr	73	18	)	)	-RRB-
cord-260054-iihgc5nr	73	19	,	,	,
cord-260054-iihgc5nr	73	20	only	only	RB
cord-260054-iihgc5nr	73	21	5	5	CD
cord-260054-iihgc5nr	73	22	other	other	JJ
cord-260054-iihgc5nr	73	23	mutations	mutation	NNS
cord-260054-iihgc5nr	73	24	(	(	-LRB-
cord-260054-iihgc5nr	73	25	two	two	CD
cord-260054-iihgc5nr	73	26	of	of	IN
cord-260054-iihgc5nr	73	27	them	-PRON-	PRP
cord-260054-iihgc5nr	73	28	being	be	VBG
cord-260054-iihgc5nr	73	29	very	very	RB
cord-260054-iihgc5nr	73	30	peripheral	peripheral	JJ
cord-260054-iihgc5nr	73	31	,	,	,
cord-260054-iihgc5nr	73	32	L5F	l5f	NN
cord-260054-iihgc5nr	73	33	and	and	CC
cord-260054-iihgc5nr	73	34	P1263L	P1263L	NNP
cord-260054-iihgc5nr	73	35	)	)	-RRB-
cord-260054-iihgc5nr	73	36	recurred	recur	VBD
cord-260054-iihgc5nr	73	37	indeed	indeed	RB
cord-260054-iihgc5nr	73	38	in	in	IN
cord-260054-iihgc5nr	73	39	≥	≥	CD
cord-260054-iihgc5nr	73	40	20	20	CD
cord-260054-iihgc5nr	73	41	sequences	sequence	NNS
cord-260054-iihgc5nr	73	42	(	(	-LRB-
cord-260054-iihgc5nr	73	43	see	see	VB
cord-260054-iihgc5nr	73	44	Table	Table	NNP
cord-260054-iihgc5nr	73	45	S1	S1	NNP
cord-260054-iihgc5nr	73	46	)	)	-RRB-
cord-260054-iihgc5nr	73	47	.	.	.
cord-260054-iihgc5nr	74	1	S943P	S943P	NNP
cord-260054-iihgc5nr	74	2	was	be	VBD
cord-260054-iihgc5nr	74	3	also	also	RB
cord-260054-iihgc5nr	74	4	reported	report	VBN
cord-260054-iihgc5nr	74	5	in	in	IN
cord-260054-iihgc5nr	74	6	(	(	-LRB-
cord-260054-iihgc5nr	74	7	38	38	CD
cord-260054-iihgc5nr	74	8	)	)	-RRB-
cord-260054-iihgc5nr	74	9	,	,	,
cord-260054-iihgc5nr	74	10	where	where	WRB
cord-260054-iihgc5nr	74	11	it	-PRON-	PRP
cord-260054-iihgc5nr	74	12	was	be	VBD
cord-260054-iihgc5nr	74	13	hypothesized	hypothesize	VBN
cord-260054-iihgc5nr	74	14	to	to	TO
cord-260054-iihgc5nr	74	15	be	be	VB
cord-260054-iihgc5nr	74	16	spreading	spread	VBG
cord-260054-iihgc5nr	74	17	via	via	IN
cord-260054-iihgc5nr	74	18	recombination	recombination	NN
cord-260054-iihgc5nr	74	19	.	.	.
cord-260054-iihgc5nr	75	1	The	the	DT
cord-260054-iihgc5nr	75	2	L938F	L938F	NNP
cord-260054-iihgc5nr	75	3	mutation	mutation	NN
cord-260054-iihgc5nr	75	4	was	be	VBD
cord-260054-iihgc5nr	75	5	a	a	DT
cord-260054-iihgc5nr	75	6	particularly	particularly	RB
cord-260054-iihgc5nr	75	7	late	late	JJ
cord-260054-iihgc5nr	75	8	one	one	CD
cord-260054-iihgc5nr	75	9	;	;	:
cord-260054-iihgc5nr	75	10	it	-PRON-	PRP
cord-260054-iihgc5nr	75	11	was	be	VBD
cord-260054-iihgc5nr	75	12	found	find	VBN
cord-260054-iihgc5nr	75	13	in	in	IN
cord-260054-iihgc5nr	75	14	2	2	CD
cord-260054-iihgc5nr	75	15	sequences	sequence	NNS
cord-260054-iihgc5nr	75	16	,	,	,
cord-260054-iihgc5nr	75	17	associated	associate	VBN
cord-260054-iihgc5nr	75	18	to	to	IN
cord-260054-iihgc5nr	75	19	the	the	DT
cord-260054-iihgc5nr	75	20	D614	d614	NN
cord-260054-iihgc5nr	75	21	G	g	NN
cord-260054-iihgc5nr	75	22	mutation	mutation	NN
cord-260054-iihgc5nr	75	23	,	,	,
cord-260054-iihgc5nr	75	24	both	both	CC
cord-260054-iihgc5nr	75	25	from	from	IN
cord-260054-iihgc5nr	75	26	England	England	NNP
cord-260054-iihgc5nr	75	27	and	and	CC
cord-260054-iihgc5nr	75	28	dated	date	VBN
cord-260054-iihgc5nr	75	29	March	March	NNP
cord-260054-iihgc5nr	75	30	29	29	CD
cord-260054-iihgc5nr	75	31	th	th	XX
cord-260054-iihgc5nr	75	32	.	.	.
cord-260054-iihgc5nr	76	1	The	the	DT
cord-260054-iihgc5nr	76	2	S929I	S929I	NNP
cord-260054-iihgc5nr	76	3	mutation	mutation	NN
cord-260054-iihgc5nr	76	4	was	be	VBD
cord-260054-iihgc5nr	76	5	found	find	VBN
cord-260054-iihgc5nr	76	6	in	in	IN
cord-260054-iihgc5nr	76	7	2	2	CD
cord-260054-iihgc5nr	76	8	sequences	sequence	NNS
cord-260054-iihgc5nr	76	9	from	from	IN
cord-260054-iihgc5nr	76	10	USA	USA	NNP
cord-260054-iihgc5nr	76	11	(	(	-LRB-
cord-260054-iihgc5nr	76	12	Washington	Washington	NNP
cord-260054-iihgc5nr	76	13	)	)	-RRB-
cord-260054-iihgc5nr	76	14	,	,	,
cord-260054-iihgc5nr	76	15	dated	date	VBN
cord-260054-iihgc5nr	76	16	March	March	NNP
cord-260054-iihgc5nr	76	17	12	12	CD
cord-260054-iihgc5nr	76	18	th	th	XX
cord-260054-iihgc5nr	76	19	and	and	CC
cord-260054-iihgc5nr	76	20	27	27	CD
cord-260054-iihgc5nr	76	21	th	th	XX
cord-260054-iihgc5nr	76	22	,	,	,
cord-260054-iihgc5nr	76	23	associated	associate	VBN
cord-260054-iihgc5nr	76	24	to	to	IN
cord-260054-iihgc5nr	76	25	the	the	DT
cord-260054-iihgc5nr	76	26	D614	d614	NN
cord-260054-iihgc5nr	76	27	G	g	NN
cord-260054-iihgc5nr	76	28	mutation	mutation	NN
cord-260054-iihgc5nr	76	29	.	.	.
cord-260054-iihgc5nr	77	1	Finally	finally	RB
cord-260054-iihgc5nr	77	2	,	,	,
cord-260054-iihgc5nr	77	3	the	the	DT
cord-260054-iihgc5nr	77	4	S940F	S940F	NNP
cord-260054-iihgc5nr	77	5	mutation	mutation	NN
cord-260054-iihgc5nr	77	6	had	have	VBD
cord-260054-iihgc5nr	77	7	a	a	DT
cord-260054-iihgc5nr	77	8	unique	unique	JJ
cord-260054-iihgc5nr	77	9	geographical	geographical	JJ
cord-260054-iihgc5nr	77	10	distribution	distribution	NN
cord-260054-iihgc5nr	77	11	,	,	,
cord-260054-iihgc5nr	77	12	as	as	IN
cord-260054-iihgc5nr	77	13	it	-PRON-	PRP
cord-260054-iihgc5nr	77	14	was	be	VBD
cord-260054-iihgc5nr	77	15	found	find	VBN
cord-260054-iihgc5nr	77	16	in	in	IN
cord-260054-iihgc5nr	77	17	2	2	CD
cord-260054-iihgc5nr	77	18	sequences	sequence	NNS
cord-260054-iihgc5nr	77	19	from	from	IN
cord-260054-iihgc5nr	77	20	Australia	Australia	NNP
cord-260054-iihgc5nr	77	21	(	(	-LRB-
cord-260054-iihgc5nr	77	22	New	New	NNP
cord-260054-iihgc5nr	77	23	South	South	NNP
cord-260054-iihgc5nr	77	24	Wales	Wales	NNP
cord-260054-iihgc5nr	77	25	)	)	-RRB-
cord-260054-iihgc5nr	77	26	dated	date	VBD
cord-260054-iihgc5nr	77	27	February	February	NNP
cord-260054-iihgc5nr	77	28	28	28	CD
cord-260054-iihgc5nr	77	29	th	th	XX
cord-260054-iihgc5nr	77	30	and	and	CC
cord-260054-iihgc5nr	77	31	March	March	NNP
cord-260054-iihgc5nr	77	32	4	4	CD
cord-260054-iihgc5nr	77	33	th	th	XX
cord-260054-iihgc5nr	77	34	,	,	,
cord-260054-iihgc5nr	77	35	not	not	RB
cord-260054-iihgc5nr	77	36	associated	associate	VBN
cord-260054-iihgc5nr	77	37	to	to	IN
cord-260054-iihgc5nr	77	38	the	the	DT
cord-260054-iihgc5nr	77	39	D614	d614	NN
cord-260054-iihgc5nr	77	40	G	g	NN
cord-260054-iihgc5nr	77	41	mutation	mutation	NN
cord-260054-iihgc5nr	77	42	.	.	.
cord-260054-iihgc5nr	78	1	In	in	IN
cord-260054-iihgc5nr	78	2	addition	addition	NN
cord-260054-iihgc5nr	78	3	,	,	,
cord-260054-iihgc5nr	78	4	it	-PRON-	PRP
cord-260054-iihgc5nr	78	5	was	be	VBD
cord-260054-iihgc5nr	78	6	found	find	VBN
cord-260054-iihgc5nr	78	7	in	in	IN
cord-260054-iihgc5nr	78	8	1	1	CD
cord-260054-iihgc5nr	78	9	single	single	JJ
cord-260054-iihgc5nr	78	10	sequence	sequence	NN
cord-260054-iihgc5nr	78	11	from	from	IN
cord-260054-iihgc5nr	78	12	France	France	NNP
cord-260054-iihgc5nr	78	13	,	,	,
cord-260054-iihgc5nr	78	14	dated	date	VBN
cord-260054-iihgc5nr	78	15	March	March	NNP
cord-260054-iihgc5nr	78	16	20	20	CD
cord-260054-iihgc5nr	78	17	th	th	XX
cord-260054-iihgc5nr	78	18	,	,	,
cord-260054-iihgc5nr	78	19	where	where	WRB
cord-260054-iihgc5nr	78	20	it	-PRON-	PRP
cord-260054-iihgc5nr	78	21	was	be	VBD
cord-260054-iihgc5nr	78	22	associated	associate	VBN
cord-260054-iihgc5nr	78	23	to	to	IN
cord-260054-iihgc5nr	78	24	the	the	DT
cord-260054-iihgc5nr	78	25	D614	d614	NN
cord-260054-iihgc5nr	78	26	G	g	NN
cord-260054-iihgc5nr	78	27	mutation	mutation	NN
cord-260054-iihgc5nr	78	28	.	.	.
cord-260054-iihgc5nr	79	1	In	in	IN
cord-260054-iihgc5nr	79	2	conclusion	conclusion	NN
cord-260054-iihgc5nr	79	3	,	,	,
cord-260054-iihgc5nr	79	4	with	with	IN
cord-260054-iihgc5nr	79	5	the	the	DT
cord-260054-iihgc5nr	79	6	exception	exception	NN
cord-260054-iihgc5nr	79	7	of	of	IN
cord-260054-iihgc5nr	79	8	S940F	S940F	NNP
cord-260054-iihgc5nr	79	9	,	,	,
cord-260054-iihgc5nr	79	10	which	which	WDT
cord-260054-iihgc5nr	79	11	was	be	VBD
cord-260054-iihgc5nr	79	12	found	find	VBN
cord-260054-iihgc5nr	79	13	in	in	IN
cord-260054-iihgc5nr	79	14	Australia	Australia	NNP
cord-260054-iihgc5nr	79	15	,	,	,
cord-260054-iihgc5nr	79	16	all	all	PDT
cord-260054-iihgc5nr	79	17	the	the	DT
cord-260054-iihgc5nr	79	18	mutations	mutation	NNS
cord-260054-iihgc5nr	79	19	in	in	IN
cord-260054-iihgc5nr	79	20	the	the	DT
cord-260054-iihgc5nr	79	21	HR1	HR1	NNP
cord-260054-iihgc5nr	79	22	core	core	NN
cord-260054-iihgc5nr	79	23	fusion	fusion	NN
cord-260054-iihgc5nr	79	24	were	be	VBD
cord-260054-iihgc5nr	79	25	spread	spread	VBN
cord-260054-iihgc5nr	79	26	in	in	IN
cord-260054-iihgc5nr	79	27	two	two	CD
cord-260054-iihgc5nr	79	28	continents	continent	NNS
cord-260054-iihgc5nr	79	29	,	,	,
cord-260054-iihgc5nr	79	30	Europe	Europe	NNP
cord-260054-iihgc5nr	79	31	and/or	and/or	CC
cord-260054-iihgc5nr	79	32	North	North	NNP
cord-260054-iihgc5nr	79	33	America	America	NNP
cord-260054-iihgc5nr	79	34	.	.	.
cord-260054-iihgc5nr	80	1	Furthermore	furthermore	RB
cord-260054-iihgc5nr	80	2	,	,	,
cord-260054-iihgc5nr	80	3	most	most	JJS
cord-260054-iihgc5nr	80	4	of	of	IN
cord-260054-iihgc5nr	80	5	them	-PRON-	PRP
cord-260054-iihgc5nr	80	6	originated	originate	VBD
cord-260054-iihgc5nr	80	7	from	from	IN
cord-260054-iihgc5nr	80	8	the	the	DT
cord-260054-iihgc5nr	80	9	D614	d614	CD
cord-260054-iihgc5nr	80	10	G	g	NN
cord-260054-iihgc5nr	80	11	variant	variant	NN
cord-260054-iihgc5nr	80	12	.	.	.
cord-260054-iihgc5nr	81	1	This	this	DT
cord-260054-iihgc5nr	81	2	is	be	VBZ
cord-260054-iihgc5nr	81	3	in	in	IN
cord-260054-iihgc5nr	81	4	agreement	agreement	NN
cord-260054-iihgc5nr	81	5	with	with	IN
cord-260054-iihgc5nr	81	6	them	-PRON-	PRP
cord-260054-iihgc5nr	81	7	seeming	seeming	JJ
cord-260054-iihgc5nr	81	8	to	to	TO
cord-260054-iihgc5nr	81	9	be	be	VB
cord-260054-iihgc5nr	81	10	quite	quite	RB
cord-260054-iihgc5nr	81	11	late	late	JJ
cord-260054-iihgc5nr	81	12	mutations	mutation	NNS
cord-260054-iihgc5nr	81	13	,	,	,
cord-260054-iihgc5nr	81	14	sequenced	sequence	VBN
cord-260054-iihgc5nr	81	15	starting	start	VBG
cord-260054-iihgc5nr	81	16	from	from	IN
cord-260054-iihgc5nr	81	17	the	the	DT
cord-260054-iihgc5nr	81	18	end	end	NN
cord-260054-iihgc5nr	81	19	of	of	IN
cord-260054-iihgc5nr	81	20	February	February	NNP
cord-260054-iihgc5nr	81	21	/	/	SYM
cord-260054-iihgc5nr	81	22	March	March	NNP
cord-260054-iihgc5nr	81	23	2020	2020	CD
cord-260054-iihgc5nr	81	24	,	,	,
cord-260054-iihgc5nr	81	25	i.e.	i.e.	FW
cord-260054-iihgc5nr	81	26	over	over	IN
cord-260054-iihgc5nr	81	27	two	two	CD
cord-260054-iihgc5nr	81	28	months	month	NNS
cord-260054-iihgc5nr	81	29	after	after	IN
cord-260054-iihgc5nr	81	30	the	the	DT
cord-260054-iihgc5nr	81	31	first	first	JJ
cord-260054-iihgc5nr	81	32	Wuhan	Wuhan	NNP
cord-260054-iihgc5nr	81	33	variant	variant	NN
cord-260054-iihgc5nr	81	34	dated	date	VBN
cord-260054-iihgc5nr	81	35	December	December	NNP
cord-260054-iihgc5nr	81	36	24	24	CD
cord-260054-iihgc5nr	81	37	th	th	XX
cord-260054-iihgc5nr	81	38	2019	2019	CD
cord-260054-iihgc5nr	81	39	(	(	-LRB-
cord-260054-iihgc5nr	81	40	30	30	CD
cord-260054-iihgc5nr	81	41	)	)	-RRB-
cord-260054-iihgc5nr	82	1	(	(	-LRB-
cord-260054-iihgc5nr	82	2	Table	table	NN
cord-260054-iihgc5nr	82	3	1	1	CD
cord-260054-iihgc5nr	82	4	)	)	-RRB-
cord-260054-iihgc5nr	83	1	The	the	DT
cord-260054-iihgc5nr	83	2	≈3-fold	≈3-fold	NNP
cord-260054-iihgc5nr	83	3	increment	increment	NN
cord-260054-iihgc5nr	83	4	in	in	IN
cord-260054-iihgc5nr	83	5	frequency	frequency	NN
cord-260054-iihgc5nr	83	6	of	of	IN
cord-260054-iihgc5nr	83	7	the	the	DT
cord-260054-iihgc5nr	83	8	S929I	S929I	NNP
cord-260054-iihgc5nr	83	9	and	and	CC
cord-260054-iihgc5nr	83	10	S939F	S939F	NNP
cord-260054-iihgc5nr	83	11	mutants	mutant	NNS
cord-260054-iihgc5nr	83	12	was	be	VBD
cord-260054-iihgc5nr	83	13	in	in	IN
cord-260054-iihgc5nr	83	14	line	line	NN
cord-260054-iihgc5nr	83	15	with	with	IN
cord-260054-iihgc5nr	83	16	the	the	DT
cord-260054-iihgc5nr	83	17	increment	increment	NN
cord-260054-iihgc5nr	83	18	of	of	IN
cord-260054-iihgc5nr	83	19	the	the	DT
cord-260054-iihgc5nr	83	20	sequences	sequence	NNS
cord-260054-iihgc5nr	83	21	in	in	IN
cord-260054-iihgc5nr	83	22	the	the	DT
cord-260054-iihgc5nr	83	23	dataset	dataset	NN
cord-260054-iihgc5nr	83	24	.	.	.
cord-260054-iihgc5nr	84	1	The	the	DT
cord-260054-iihgc5nr	84	2	three	three	CD
cord-260054-iihgc5nr	84	3	additional	additional	JJ
cord-260054-iihgc5nr	84	4	occurrences	occurrence	NNS
cord-260054-iihgc5nr	84	5	of	of	IN
cord-260054-iihgc5nr	84	6	the	the	DT
cord-260054-iihgc5nr	84	7	S929I	S929I	NNP
cord-260054-iihgc5nr	84	8	mutation	mutation	NN
cord-260054-iihgc5nr	84	9	were	be	VBD
cord-260054-iihgc5nr	84	10	from	from	IN
cord-260054-iihgc5nr	84	11	USA	USA	NNP
cord-260054-iihgc5nr	84	12	(	(	-LRB-
cord-260054-iihgc5nr	84	13	Washington	Washington	NNP
cord-260054-iihgc5nr	84	14	)	)	-RRB-
cord-260054-iihgc5nr	84	15	,	,	,
cord-260054-iihgc5nr	84	16	Wales	Wales	NNP
cord-260054-iihgc5nr	84	17	and	and	CC
cord-260054-iihgc5nr	84	18	England	England	NNP
cord-260054-iihgc5nr	84	19	.	.	.
cord-260054-iihgc5nr	85	1	A	a	DT
cord-260054-iihgc5nr	85	2	novel	novel	JJ
cord-260054-iihgc5nr	85	3	S929	s929	NN
cord-260054-iihgc5nr	85	4	T	t	NN
cord-260054-iihgc5nr	85	5	mutation	mutation	NN
cord-260054-iihgc5nr	85	6	was	be	VBD
cord-260054-iihgc5nr	85	7	also	also	RB
cord-260054-iihgc5nr	85	8	reported	report	VBN
cord-260054-iihgc5nr	85	9	twice	twice	RB
cord-260054-iihgc5nr	85	10	from	from	IN
cord-260054-iihgc5nr	85	11	Scotland	Scotland	NNP
cord-260054-iihgc5nr	85	12	.	.	.
cord-260054-iihgc5nr	86	1	Additional	additional	JJ
cord-260054-iihgc5nr	86	2	occurrences	occurrence	NNS
cord-260054-iihgc5nr	86	3	of	of	IN
cord-260054-iihgc5nr	86	4	the	the	DT
cord-260054-iihgc5nr	86	5	S939F	S939F	NNP
cord-260054-iihgc5nr	86	6	mutation	mutation	NN
cord-260054-iihgc5nr	86	7	were	be	VBD
cord-260054-iihgc5nr	86	8	instead	instead	RB
cord-260054-iihgc5nr	86	9	from	from	IN
cord-260054-iihgc5nr	86	10	USA	USA	NNP
cord-260054-iihgc5nr	86	11	,	,	,
cord-260054-iihgc5nr	86	12	7	7	CD
cord-260054-iihgc5nr	86	13	,	,	,
cord-260054-iihgc5nr	86	14	England	England	NNP
cord-260054-iihgc5nr	86	15	,	,	,
cord-260054-iihgc5nr	86	16	2	2	CD
cord-260054-iihgc5nr	86	17	,	,	,
cord-260054-iihgc5nr	86	18	Kazakhstan	Kazakhstan	NNP
cord-260054-iihgc5nr	86	19	,	,	,
cord-260054-iihgc5nr	86	20	1	1	CD
cord-260054-iihgc5nr	86	21	,	,	,
cord-260054-iihgc5nr	86	22	and	and	CC
cord-260054-iihgc5nr	86	23	UAE	UAE	NNP
cord-260054-iihgc5nr	86	24	,	,	,
cord-260054-iihgc5nr	86	25	1	1	CD
cord-260054-iihgc5nr	86	26	.	.	.
cord-260054-iihgc5nr	87	1	As	as	IN
cord-260054-iihgc5nr	87	2	for	for	IN
cord-260054-iihgc5nr	87	3	the	the	DT
cord-260054-iihgc5nr	87	4	L938F	L938F	NNP
cord-260054-iihgc5nr	87	5	and	and	CC
cord-260054-iihgc5nr	87	6	S940F	S940F	NNP
cord-260054-iihgc5nr	87	7	mutants	mutant	NNS
cord-260054-iihgc5nr	87	8	,	,	,
cord-260054-iihgc5nr	87	9	their	-PRON-	PRP$
cord-260054-iihgc5nr	87	10	increment	increment	NN
cord-260054-iihgc5nr	87	11	was	be	VBD
cord-260054-iihgc5nr	87	12	significantly	significantly	RB
cord-260054-iihgc5nr	87	13	lower	low	JJR
cord-260054-iihgc5nr	87	14	than	than	IN
cord-260054-iihgc5nr	87	15	the	the	DT
cord-260054-iihgc5nr	87	16	increment	increment	NN
cord-260054-iihgc5nr	87	17	of	of	IN
cord-260054-iihgc5nr	87	18	the	the	DT
cord-260054-iihgc5nr	87	19	sequences	sequence	NNS
cord-260054-iihgc5nr	87	20	in	in	IN
cord-260054-iihgc5nr	87	21	the	the	DT
cord-260054-iihgc5nr	87	22	dataset	dataset	NN
cord-260054-iihgc5nr	87	23	.	.	.
cord-260054-iihgc5nr	88	1	A	a	DT
cord-260054-iihgc5nr	88	2	positive	positive	JJ
cord-260054-iihgc5nr	88	3	selection	selection	NN
cord-260054-iihgc5nr	88	4	thus	thus	RB
cord-260054-iihgc5nr	88	5	clearly	clearly	RB
cord-260054-iihgc5nr	88	6	has	have	VBZ
cord-260054-iihgc5nr	88	7	n't	not	RB
cord-260054-iihgc5nr	88	8	emerged	emerge	VBN
cord-260054-iihgc5nr	88	9	to	to	IN
cord-260054-iihgc5nr	88	10	date	date	NN
cord-260054-iihgc5nr	88	11	for	for	IN
cord-260054-iihgc5nr	88	12	these	these	DT
cord-260054-iihgc5nr	88	13	mutations	mutation	NNS
cord-260054-iihgc5nr	88	14	.	.	.
cord-260054-iihgc5nr	89	1	The	the	DT
cord-260054-iihgc5nr	89	2	only	only	JJ
cord-260054-iihgc5nr	89	3	additional	additional	JJ
cord-260054-iihgc5nr	89	4	occurrence	occurrence	NN
cord-260054-iihgc5nr	89	5	of	of	IN
cord-260054-iihgc5nr	89	6	L938F	L938F	NNP
cord-260054-iihgc5nr	89	7	was	be	VBD
cord-260054-iihgc5nr	89	8	from	from	IN
cord-260054-iihgc5nr	89	9	Denmark	Denmark	NNP
cord-260054-iihgc5nr	89	10	,	,	,
cord-260054-iihgc5nr	89	11	while	while	IN
cord-260054-iihgc5nr	89	12	the	the	DT
cord-260054-iihgc5nr	89	13	2	2	CD
cord-260054-iihgc5nr	89	14	additional	additional	JJ
cord-260054-iihgc5nr	89	15	occurrences	occurrence	NNS
cord-260054-iihgc5nr	89	16	of	of	IN
cord-260054-iihgc5nr	89	17	S940F	S940F	NNPS
cord-260054-iihgc5nr	89	18	were	be	VBD
cord-260054-iihgc5nr	89	19	from	from	IN
cord-260054-iihgc5nr	89	20	France	France	NNP
cord-260054-iihgc5nr	89	21	and	and	CC
cord-260054-iihgc5nr	89	22	USA	USA	NNP
cord-260054-iihgc5nr	89	23	(	(	-LRB-
cord-260054-iihgc5nr	89	24	Washington	Washington	NNP
cord-260054-iihgc5nr	89	25	)	)	-RRB-
cord-260054-iihgc5nr	89	26	.	.	.
cord-260054-iihgc5nr	90	1	The	the	DT
cord-260054-iihgc5nr	90	2	S943P	S943P	NNP
cord-260054-iihgc5nr	90	3	mutation	mutation	NN
cord-260054-iihgc5nr	90	4	represented	represent	VBD
cord-260054-iihgc5nr	90	5	a	a	DT
cord-260054-iihgc5nr	90	6	special	special	JJ
cord-260054-iihgc5nr	90	7	case	case	NN
cord-260054-iihgc5nr	90	8	.	.	.
cord-260054-iihgc5nr	91	1	Most	Most	JJS
cord-260054-iihgc5nr	91	2	of	of	IN
cord-260054-iihgc5nr	91	3	the	the	DT
cord-260054-iihgc5nr	91	4	sequences	sequence	NNS
cord-260054-iihgc5nr	91	5	harbouring	harbour	VBG
cord-260054-iihgc5nr	91	6	such	such	PDT
cord-260054-iihgc5nr	91	7	a	a	DT
cord-260054-iihgc5nr	91	8	mutation	mutation	NN
cord-260054-iihgc5nr	91	9	were	be	VBD
cord-260054-iihgc5nr	91	10	indeed	indeed	RB
cord-260054-iihgc5nr	91	11	modified	modify	VBN
cord-260054-iihgc5nr	91	12	between	between	IN
cord-260054-iihgc5nr	91	13	the	the	DT
cord-260054-iihgc5nr	91	14	April	April	NNP
cord-260054-iihgc5nr	91	15	21	21	CD
cord-260054-iihgc5nr	91	16	st	st	NNP
cord-260054-iihgc5nr	91	17	and	and	CC
cord-260054-iihgc5nr	91	18	the	the	DT
cord-260054-iihgc5nr	91	19	May	May	NNP
cord-260054-iihgc5nr	91	20	29	29	CD
cord-260054-iihgc5nr	91	21	th	th	XX
cord-260054-iihgc5nr	91	22	datasets	dataset	NNS
cord-260054-iihgc5nr	91	23	,	,	,
cord-260054-iihgc5nr	91	24	so	so	IN
cord-260054-iihgc5nr	91	25	that	that	IN
cord-260054-iihgc5nr	91	26	they	-PRON-	PRP
cord-260054-iihgc5nr	91	27	do	do	VBP
cord-260054-iihgc5nr	91	28	not	not	RB
cord-260054-iihgc5nr	91	29	feature	feature	VB
cord-260054-iihgc5nr	91	30	anymore	anymore	RB
cord-260054-iihgc5nr	91	31	the	the	DT
cord-260054-iihgc5nr	91	32	mutation	mutation	NN
cord-260054-iihgc5nr	91	33	to	to	IN
cord-260054-iihgc5nr	91	34	proline	proline	NN
cord-260054-iihgc5nr	91	35	.	.	.
cord-260054-iihgc5nr	92	1	However	however	RB
cord-260054-iihgc5nr	92	2	,	,	,
cord-260054-iihgc5nr	92	3	3	3	CD
cord-260054-iihgc5nr	92	4	novel	novel	JJ
cord-260054-iihgc5nr	92	5	occurrences	occurrence	NNS
cord-260054-iihgc5nr	92	6	of	of	IN
cord-260054-iihgc5nr	92	7	the	the	DT
cord-260054-iihgc5nr	92	8	same	same	JJ
cord-260054-iihgc5nr	92	9	mutation	mutation	NN
cord-260054-iihgc5nr	92	10	,	,	,
cord-260054-iihgc5nr	92	11	S943P	S943P	NNP
cord-260054-iihgc5nr	92	12	,	,	,
cord-260054-iihgc5nr	92	13	emerged	emerge	VBD
cord-260054-iihgc5nr	92	14	from	from	IN
cord-260054-iihgc5nr	92	15	China	China	NNP
cord-260054-iihgc5nr	92	16	(	(	-LRB-
cord-260054-iihgc5nr	92	17	Beijing	Beijing	NNP
cord-260054-iihgc5nr	92	18	)	)	-RRB-
cord-260054-iihgc5nr	92	19	.	.	.
cord-260054-iihgc5nr	93	1	In	in	IN
cord-260054-iihgc5nr	93	2	addition	addition	NN
cord-260054-iihgc5nr	93	3	,	,	,
cord-260054-iihgc5nr	93	4	3	3	CD
cord-260054-iihgc5nr	93	5	sequences	sequence	NNS
cord-260054-iihgc5nr	93	6	from	from	IN
cord-260054-iihgc5nr	93	7	Scotland	Scotland	NNP
cord-260054-iihgc5nr	93	8	presented	present	VBD
cord-260054-iihgc5nr	93	9	the	the	DT
cord-260054-iihgc5nr	93	10	novel	novel	JJ
cord-260054-iihgc5nr	93	11	S943I	S943I	NNP
cord-260054-iihgc5nr	93	12	mutation	mutation	NN
cord-260054-iihgc5nr	93	13	.	.	.
cord-260054-iihgc5nr	94	1	As	as	IN
cord-260054-iihgc5nr	94	2	for	for	IN
cord-260054-iihgc5nr	94	3	the	the	DT
cord-260054-iihgc5nr	94	4	remaining	remain	VBG
cord-260054-iihgc5nr	94	5	positions	position	NNS
cord-260054-iihgc5nr	94	6	of	of	IN
cord-260054-iihgc5nr	94	7	the	the	DT
cord-260054-iihgc5nr	94	8	HR1	HR1	NNP
cord-260054-iihgc5nr	94	9	fusion	fusion	NN
cord-260054-iihgc5nr	94	10	core	core	NN
cord-260054-iihgc5nr	94	11	,	,	,
cord-260054-iihgc5nr	94	12	to	to	IN
cord-260054-iihgc5nr	94	13	May	May	NNP
cord-260054-iihgc5nr	94	14	29	29	CD
cord-260054-iihgc5nr	94	15	th	th	XX
cord-260054-iihgc5nr	94	16	,	,	,
cord-260054-iihgc5nr	94	17	either	either	CC
cord-260054-iihgc5nr	94	18	they	-PRON-	PRP
cord-260054-iihgc5nr	94	19	were	be	VBD
cord-260054-iihgc5nr	94	20	fully	fully	RB
cord-260054-iihgc5nr	94	21	conserved	conserve	VBN
cord-260054-iihgc5nr	94	22	(	(	-LRB-
cord-260054-iihgc5nr	94	23	S937	s937	CC
cord-260054-iihgc5nr	94	24	,	,	,
cord-260054-iihgc5nr	94	25	K933	K933	NNP
cord-260054-iihgc5nr	94	26	,	,	,
cord-260054-iihgc5nr	94	27	A942	A942	NNP
cord-260054-iihgc5nr	94	28	,	,	,
cord-260054-iihgc5nr	94	29	A944	A944	NNP
cord-260054-iihgc5nr	94	30	,	,	,
cord-260054-iihgc5nr	94	31	L945	L945	NNP
cord-260054-iihgc5nr	94	32	,	,	,
cord-260054-iihgc5nr	94	33	G946	G946	NNP
cord-260054-iihgc5nr	94	34	,	,	,
cord-260054-iihgc5nr	94	35	K947	K947	NNP
cord-260054-iihgc5nr	94	36	and	and	CC
cord-260054-iihgc5nr	94	37	Q949	Q949	NNP
cord-260054-iihgc5nr	94	38	)	)	-RRB-
cord-260054-iihgc5nr	94	39	,	,	,
cord-260054-iihgc5nr	94	40	or	or	CC
cord-260054-iihgc5nr	94	41	they	-PRON-	PRP
cord-260054-iihgc5nr	94	42	hosted	host	VBD
cord-260054-iihgc5nr	94	43	one	one	CD
cord-260054-iihgc5nr	94	44	single	single	JJ
cord-260054-iihgc5nr	94	45	occurrence	occurrence	NN
cord-260054-iihgc5nr	94	46	of	of	IN
cord-260054-iihgc5nr	94	47	mutation	mutation	NN
cord-260054-iihgc5nr	94	48	(	(	-LRB-
cord-260054-iihgc5nr	94	49	to	to	IN
cord-260054-iihgc5nr	94	50	valine	valine	NN
cord-260054-iihgc5nr	94	51	for	for	IN
cord-260054-iihgc5nr	94	52	A930	A930	NNP
cord-260054-iihgc5nr	94	53	,	,	,
cord-260054-iihgc5nr	94	54	to	to	IN
cord-260054-iihgc5nr	94	55	aspartate	aspartate	VB
cord-260054-iihgc5nr	94	56	for	for	IN
cord-260054-iihgc5nr	94	57	I931	I931	NNPS
cord-260054-iihgc5nr	94	58	and	and	CC
cord-260054-iihgc5nr	94	59	G932	G932	NNPS
cord-260054-iihgc5nr	94	60	,	,	,
cord-260054-iihgc5nr	94	61	to	to	TO
cord-260054-iihgc5nr	94	62	histidine	histidine	VB
cord-260054-iihgc5nr	94	63	for	for	IN
cord-260054-iihgc5nr	94	64	Q934	Q934	NNP
cord-260054-iihgc5nr	94	65	and	and	CC
cord-260054-iihgc5nr	94	66	D935	D935	NNP
cord-260054-iihgc5nr	94	67	,	,	,
cord-260054-iihgc5nr	94	68	to	to	IN
cord-260054-iihgc5nr	94	69	alanine	alanine	NN
cord-260054-iihgc5nr	94	70	for	for	IN
cord-260054-iihgc5nr	94	71	T941	T941	NNP
cord-260054-iihgc5nr	94	72	and	and	CC
cord-260054-iihgc5nr	94	73	to	to	IN
cord-260054-iihgc5nr	94	74	arginine	arginine	NN
cord-260054-iihgc5nr	94	75	for	for	IN
cord-260054-iihgc5nr	94	76	L948	L948	NNP
cord-260054-iihgc5nr	94	77	)	)	-RRB-
cord-260054-iihgc5nr	94	78	.	.	.
cord-260054-iihgc5nr	95	1	Because	because	IN
cord-260054-iihgc5nr	95	2	of	of	IN
cord-260054-iihgc5nr	95	3	the	the	DT
cord-260054-iihgc5nr	95	4	rarity	rarity	NN
cord-260054-iihgc5nr	95	5	of	of	IN
cord-260054-iihgc5nr	95	6	such	such	JJ
cord-260054-iihgc5nr	95	7	mutations	mutation	NNS
cord-260054-iihgc5nr	95	8	,	,	,
cord-260054-iihgc5nr	95	9	we	-PRON-	PRP
cord-260054-iihgc5nr	95	10	will	will	MD
cord-260054-iihgc5nr	95	11	not	not	RB
cord-260054-iihgc5nr	95	12	discuss	discuss	VB
cord-260054-iihgc5nr	95	13	them	-PRON-	PRP
cord-260054-iihgc5nr	95	14	here	here	RB
cord-260054-iihgc5nr	95	15	.	.	.
cord-260054-iihgc5nr	96	1	However	however	RB
cord-260054-iihgc5nr	96	2	,	,	,
cord-260054-iihgc5nr	96	3	we	-PRON-	PRP
cord-260054-iihgc5nr	96	4	will	will	MD
cord-260054-iihgc5nr	96	5	continue	continue	VB
cord-260054-iihgc5nr	96	6	to	to	TO
cord-260054-iihgc5nr	96	7	monitor	monitor	VB
cord-260054-iihgc5nr	96	8	them	-PRON-	PRP
cord-260054-iihgc5nr	96	9	over	over	IN
cord-260054-iihgc5nr	96	10	time	time	NN
cord-260054-iihgc5nr	96	11	.	.	.
cord-260054-iihgc5nr	97	1	All	all	PDT
cord-260054-iihgc5nr	97	2	the	the	DT
cord-260054-iihgc5nr	97	3	amino	amino	NN
cord-260054-iihgc5nr	97	4	acids	acid	NNS
cord-260054-iihgc5nr	97	5	undergoing	undergo	VBG
cord-260054-iihgc5nr	98	1	mutations	mutation	NNS
cord-260054-iihgc5nr	98	2	in	in	IN
cord-260054-iihgc5nr	98	3	the	the	DT
cord-260054-iihgc5nr	98	4	SARS	SARS	NNP
cord-260054-iihgc5nr	98	5	-	-	HYPH
cord-260054-iihgc5nr	98	6	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	98	7	S	S	NNP
cord-260054-iihgc5nr	98	8	protein	protein	NN
cord-260054-iihgc5nr	98	9	are	be	VBP
cord-260054-iihgc5nr	98	10	conserved	conserve	VBN
cord-260054-iihgc5nr	98	11	in	in	IN
cord-260054-iihgc5nr	98	12	the	the	DT
cord-260054-iihgc5nr	98	13	bat	bat	NN
cord-260054-iihgc5nr	99	1	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	99	2	RaTG13	RaTG13	NNP
cord-260054-iihgc5nr	99	3	S	S	NNP
cord-260054-iihgc5nr	99	4	protein	protein	NN
cord-260054-iihgc5nr	99	5	(	(	-LRB-
cord-260054-iihgc5nr	99	6	sharing	share	VBG
cord-260054-iihgc5nr	99	7	an	an	DT
cord-260054-iihgc5nr	99	8	overall	overall	JJ
cord-260054-iihgc5nr	99	9	sequence	sequence	NN
cord-260054-iihgc5nr	99	10	identity	identity	NN
cord-260054-iihgc5nr	99	11	of	of	IN
cord-260054-iihgc5nr	99	12	97	97	CD
cord-260054-iihgc5nr	99	13	%	%	NN
cord-260054-iihgc5nr	99	14	with	with	IN
cord-260054-iihgc5nr	99	15	SARS	SARS	NNP
cord-260054-iihgc5nr	99	16	-	-	HYPH
cord-260054-iihgc5nr	99	17	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	99	18	S	S	NNP
cord-260054-iihgc5nr	99	19	protein	protein	NN
cord-260054-iihgc5nr	99	20	)	)	-RRB-
cord-260054-iihgc5nr	99	21	,	,	,
cord-260054-iihgc5nr	99	22	while	while	IN
cord-260054-iihgc5nr	99	23	as	as	RB
cord-260054-iihgc5nr	99	24	many	many	JJ
cord-260054-iihgc5nr	99	25	as	as	IN
cord-260054-iihgc5nr	99	26	five	five	CD
cord-260054-iihgc5nr	99	27	of	of	IN
cord-260054-iihgc5nr	99	28	them	-PRON-	PRP
cord-260054-iihgc5nr	99	29	are	be	VBP
cord-260054-iihgc5nr	99	30	mutated	mutate	VBN
cord-260054-iihgc5nr	99	31	in	in	IN
cord-260054-iihgc5nr	99	32	the	the	DT
cord-260054-iihgc5nr	99	33	SARS	SARS	NNP
cord-260054-iihgc5nr	99	34	-	-	HYPH
cord-260054-iihgc5nr	99	35	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	99	36	S	S	NNP
cord-260054-iihgc5nr	99	37	protein	protein	NN
cord-260054-iihgc5nr	99	38	(	(	-LRB-
cord-260054-iihgc5nr	99	39	overall	overall	JJ
cord-260054-iihgc5nr	99	40	76	76	CD
cord-260054-iihgc5nr	99	41	%	%	NN
cord-260054-iihgc5nr	99	42	sequence	sequence	NN
cord-260054-iihgc5nr	99	43	identical	identical	JJ
cord-260054-iihgc5nr	99	44	to	to	IN
cord-260054-iihgc5nr	99	45	the	the	DT
cord-260054-iihgc5nr	99	46	SARS	SARS	NNP
cord-260054-iihgc5nr	99	47	-	-	HYPH
cord-260054-iihgc5nr	99	48	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	99	49	homolog	homolog	NN
cord-260054-iihgc5nr	99	50	)	)	-RRB-
cord-260054-iihgc5nr	100	1	(	(	-LRB-
cord-260054-iihgc5nr	100	2	see	see	VB
cord-260054-iihgc5nr	100	3	Figure	figure	NN
cord-260054-iihgc5nr	100	4	1	1	CD
cord-260054-iihgc5nr	100	5	)	)	-RRB-
cord-260054-iihgc5nr	100	6	.	.	.
cord-260054-iihgc5nr	101	1	Four	four	CD
cord-260054-iihgc5nr	101	2	of	of	IN
cord-260054-iihgc5nr	101	3	these	these	DT
cord-260054-iihgc5nr	101	4	mutations	mutation	NNS
cord-260054-iihgc5nr	101	5	are	be	VBP
cord-260054-iihgc5nr	101	6	however	however	RB
cord-260054-iihgc5nr	101	7	conservative	conservative	JJ
cord-260054-iihgc5nr	101	8	(	(	-LRB-
cord-260054-iihgc5nr	101	9	aspartate	aspartate	NN
cord-260054-iihgc5nr	101	10	to	to	IN
cord-260054-iihgc5nr	101	11	glutamate	glutamate	NN
cord-260054-iihgc5nr	101	12	,	,	,
cord-260054-iihgc5nr	101	13	serine	serine	NN
cord-260054-iihgc5nr	101	14	to	to	IN
cord-260054-iihgc5nr	101	15	threonine	threonine	NN
cord-260054-iihgc5nr	101	16	)	)	-RRB-
cord-260054-iihgc5nr	101	17	,	,	,
cord-260054-iihgc5nr	101	18	except	except	IN
cord-260054-iihgc5nr	101	19	S929	s929	NN
cord-260054-iihgc5nr	101	20	,	,	,
cord-260054-iihgc5nr	101	21	which	which	WDT
cord-260054-iihgc5nr	101	22	is	be	VBZ
cord-260054-iihgc5nr	101	23	a	a	DT
cord-260054-iihgc5nr	101	24	lysine	lysine	NN
cord-260054-iihgc5nr	101	25	in	in	IN
cord-260054-iihgc5nr	101	26	SARS-	SARS-	NNP
cord-260054-iihgc5nr	102	1	CoV.	CoV.	NNP
cord-260054-iihgc5nr	103	1	It	-PRON-	PRP
cord-260054-iihgc5nr	103	2	has	have	VBZ
cord-260054-iihgc5nr	103	3	been	be	VBN
cord-260054-iihgc5nr	103	4	proposed	propose	VBN
cord-260054-iihgc5nr	103	5	that	that	IN
cord-260054-iihgc5nr	103	6	such	such	JJ
cord-260054-iihgc5nr	103	7	mutations	mutation	NNS
cord-260054-iihgc5nr	103	8	in	in	IN
cord-260054-iihgc5nr	103	9	the	the	DT
cord-260054-iihgc5nr	103	10	SARS	SARS	NNP
cord-260054-iihgc5nr	103	11	-	-	HYPH
cord-260054-iihgc5nr	103	12	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	103	13	HR1	HR1	NNP
cord-260054-iihgc5nr	103	14	may	may	MD
cord-260054-iihgc5nr	103	15	be	be	VB
cord-260054-iihgc5nr	103	16	associated	associate	VBN
cord-260054-iihgc5nr	103	17	with	with	IN
cord-260054-iihgc5nr	103	18	enhanced	enhanced	JJ
cord-260054-iihgc5nr	103	19	interactions	interaction	NNS
cord-260054-iihgc5nr	103	20	with	with	IN
cord-260054-iihgc5nr	103	21	the	the	DT
cord-260054-iihgc5nr	103	22	HR2	HR2	NNP
cord-260054-iihgc5nr	103	23	,	,	,
cord-260054-iihgc5nr	103	24	further	further	RB
cord-260054-iihgc5nr	103	25	stabilizing	stabilize	VBG
cord-260054-iihgc5nr	103	26	the	the	DT
cord-260054-iihgc5nr	103	27	6-HB	6-hb	CD
cord-260054-iihgc5nr	103	28	structure	structure	NN
cord-260054-iihgc5nr	103	29	and	and	CC
cord-260054-iihgc5nr	103	30	maybe	maybe	RB
cord-260054-iihgc5nr	103	31	leading	lead	VBG
cord-260054-iihgc5nr	103	32	to	to	IN
cord-260054-iihgc5nr	103	33	increased	increase	VBN
cord-260054-iihgc5nr	103	34	infectivity	infectivity	NN
cord-260054-iihgc5nr	103	35	of	of	IN
cord-260054-iihgc5nr	103	36	the	the	DT
cord-260054-iihgc5nr	103	37	virus	virus	NN
cord-260054-iihgc5nr	103	38	(	(	-LRB-
cord-260054-iihgc5nr	103	39	29	29	CD
cord-260054-iihgc5nr	103	40	)	)	-RRB-
cord-260054-iihgc5nr	103	41	.	.	.
cord-260054-iihgc5nr	104	1	It	-PRON-	PRP
cord-260054-iihgc5nr	104	2	is	be	VBZ
cord-260054-iihgc5nr	104	3	noteworthy	noteworthy	JJ
cord-260054-iihgc5nr	104	4	that	that	IN
cord-260054-iihgc5nr	104	5	no	no	DT
cord-260054-iihgc5nr	104	6	one	one	NN
cord-260054-iihgc5nr	104	7	of	of	IN
cord-260054-iihgc5nr	104	8	the	the	DT
cord-260054-iihgc5nr	104	9	point	point	NN
cord-260054-iihgc5nr	104	10	mutations	mutation	NNS
cord-260054-iihgc5nr	104	11	we	-PRON-	PRP
cord-260054-iihgc5nr	104	12	identified	identify	VBD
cord-260054-iihgc5nr	104	13	restored	restore	VBD
cord-260054-iihgc5nr	104	14	the	the	DT
cord-260054-iihgc5nr	104	15	corresponding	correspond	VBG
cord-260054-iihgc5nr	104	16	SARS	SARS	NNP
cord-260054-iihgc5nr	104	17	-	-	HYPH
cord-260054-iihgc5nr	104	18	CoV	cov	NN
cord-260054-iihgc5nr	104	19	amino	amino	NN
cord-260054-iihgc5nr	104	20	acid	acid	NN
cord-260054-iihgc5nr	104	21	.	.	.
cord-260054-iihgc5nr	105	1	In	in	IN
cord-260054-iihgc5nr	105	2	the	the	DT
cord-260054-iihgc5nr	105	3	pre	pre	JJ
cord-260054-iihgc5nr	105	4	-	-	JJ
cord-260054-iihgc5nr	105	5	fusion	fusion	JJ
cord-260054-iihgc5nr	105	6	conformation	conformation	NN
cord-260054-iihgc5nr	105	7	,	,	,
cord-260054-iihgc5nr	105	8	all	all	PDT
cord-260054-iihgc5nr	105	9	the	the	DT
cord-260054-iihgc5nr	105	10	mutated	mutate	VBN
cord-260054-iihgc5nr	105	11	positions	position	NNS
cord-260054-iihgc5nr	105	12	,	,	,
cord-260054-iihgc5nr	105	13	but	but	CC
cord-260054-iihgc5nr	105	14	S943	S943	NNP
cord-260054-iihgc5nr	105	15	,	,	,
cord-260054-iihgc5nr	105	16	are	be	VBP
cord-260054-iihgc5nr	105	17	located	locate	VBN
cord-260054-iihgc5nr	105	18	on	on	IN
cord-260054-iihgc5nr	105	19	the	the	DT
cord-260054-iihgc5nr	105	20	second	second	NN
cord-260054-iihgc5nr	105	21	of	of	IN
cord-260054-iihgc5nr	105	22	four	four	CD
cord-260054-iihgc5nr	105	23	non	non	JJ
cord-260054-iihgc5nr	105	24	-	-	JJ
cord-260054-iihgc5nr	105	25	coaxial	coaxial	JJ
cord-260054-iihgc5nr	105	26	helical	helical	JJ
cord-260054-iihgc5nr	105	27	segments	segment	NNS
cord-260054-iihgc5nr	105	28	composing	compose	VBG
cord-260054-iihgc5nr	105	29	the	the	DT
cord-260054-iihgc5nr	105	30	HR1	HR1	NNP
cord-260054-iihgc5nr	105	31	(	(	-LRB-
cord-260054-iihgc5nr	105	32	Figure	figure	NN
cord-260054-iihgc5nr	105	33	1	1	CD
cord-260054-iihgc5nr	105	34	)	)	-RRB-
cord-260054-iihgc5nr	105	35	.	.	.
cord-260054-iihgc5nr	106	1	Four	four	CD
cord-260054-iihgc5nr	106	2	of	of	IN
cord-260054-iihgc5nr	106	3	them	-PRON-	PRP
cord-260054-iihgc5nr	106	4	,	,	,
cord-260054-iihgc5nr	106	5	S929	s929	JJ
cord-260054-iihgc5nr	106	6	,	,	,
cord-260054-iihgc5nr	106	7	D936	D936	NNPS
cord-260054-iihgc5nr	106	8	,	,	,
cord-260054-iihgc5nr	106	9	S939	S939	NNP
cord-260054-iihgc5nr	106	10	and	and	CC
cord-260054-iihgc5nr	106	11	S940	S940	NNP
cord-260054-iihgc5nr	106	12	,	,	,
cord-260054-iihgc5nr	106	13	are	be	VBP
cord-260054-iihgc5nr	106	14	exposed	expose	VBN
cord-260054-iihgc5nr	106	15	to	to	IN
cord-260054-iihgc5nr	106	16	the	the	DT
cord-260054-iihgc5nr	106	17	solvent	solvent	NN
cord-260054-iihgc5nr	106	18	(	(	-LRB-
cord-260054-iihgc5nr	106	19	Table	Table	NNP
cord-260054-iihgc5nr	106	20	2	2	CD
cord-260054-iihgc5nr	106	21	)	)	-RRB-
cord-260054-iihgc5nr	106	22	,	,	,
cord-260054-iihgc5nr	106	23	and	and	CC
cord-260054-iihgc5nr	106	24	can	can	MD
cord-260054-iihgc5nr	106	25	be	be	VB
cord-260054-iihgc5nr	106	26	modelled	model	VBN
cord-260054-iihgc5nr	106	27	as	as	IN
cord-260054-iihgc5nr	106	28	larger	large	JJR
cord-260054-iihgc5nr	106	29	(	(	-LRB-
cord-260054-iihgc5nr	106	30	mostly	mostly	RB
cord-260054-iihgc5nr	106	31	aromatic	aromatic	JJ
cord-260054-iihgc5nr	106	32	)	)	-RRB-
cord-260054-iihgc5nr	106	33	residues	residue	NNS
cord-260054-iihgc5nr	106	34	without	without	IN
cord-260054-iihgc5nr	106	35	causing	cause	VBG
cord-260054-iihgc5nr	106	36	any	any	DT
cord-260054-iihgc5nr	106	37	structural	structural	JJ
cord-260054-iihgc5nr	106	38	strain	strain	NN
cord-260054-iihgc5nr	106	39	(	(	-LRB-
cord-260054-iihgc5nr	106	40	see	see	VB
cord-260054-iihgc5nr	106	41	Figure	figure	NN
cord-260054-iihgc5nr	106	42	2	2	CD
cord-260054-iihgc5nr	106	43	)	)	-RRB-
cord-260054-iihgc5nr	106	44	.	.	.
cord-260054-iihgc5nr	107	1	These	these	DT
cord-260054-iihgc5nr	107	2	mutations	mutation	NNS
cord-260054-iihgc5nr	107	3	are	be	VBP
cord-260054-iihgc5nr	107	4	not	not	RB
cord-260054-iihgc5nr	107	5	expected	expect	VBN
cord-260054-iihgc5nr	107	6	to	to	TO
cord-260054-iihgc5nr	107	7	cause	cause	VB
cord-260054-iihgc5nr	107	8	relevant	relevant	JJ
cord-260054-iihgc5nr	107	9	changes	change	NNS
cord-260054-iihgc5nr	107	10	in	in	IN
cord-260054-iihgc5nr	107	11	the	the	DT
cord-260054-iihgc5nr	107	12	prefusion	prefusion	NN
cord-260054-iihgc5nr	107	13	structure	structure	NN
cord-260054-iihgc5nr	107	14	,	,	,
cord-260054-iihgc5nr	107	15	although	although	IN
cord-260054-iihgc5nr	107	16	they	-PRON-	PRP
cord-260054-iihgc5nr	107	17	could	could	MD
cord-260054-iihgc5nr	107	18	have	have	VB
cord-260054-iihgc5nr	107	19	a	a	DT
cord-260054-iihgc5nr	107	20	destabilizing	destabilizing	JJ
cord-260054-iihgc5nr	107	21	effect	effect	NN
cord-260054-iihgc5nr	107	22	as	as	IN
cord-260054-iihgc5nr	107	23	a	a	DT
cord-260054-iihgc5nr	107	24	consequence	consequence	NN
cord-260054-iihgc5nr	107	25	of	of	IN
cord-260054-iihgc5nr	107	26	posing	pose	VBG
cord-260054-iihgc5nr	107	27	large	large	JJ
cord-260054-iihgc5nr	107	28	aromatic	aromatic	JJ
cord-260054-iihgc5nr	107	29	residues	residue	NNS
cord-260054-iihgc5nr	107	30	in	in	IN
cord-260054-iihgc5nr	107	31	direct	direct	JJ
cord-260054-iihgc5nr	107	32	contact	contact	NN
cord-260054-iihgc5nr	107	33	with	with	IN
cord-260054-iihgc5nr	107	34	the	the	DT
cord-260054-iihgc5nr	107	35	solvent	solvent	NN
cord-260054-iihgc5nr	107	36	instead	instead	RB
cord-260054-iihgc5nr	107	37	of	of	IN
cord-260054-iihgc5nr	107	38	smaller	small	JJR
cord-260054-iihgc5nr	107	39	apolar	apolar	NNP
cord-260054-iihgc5nr	107	40	(	(	-LRB-
cord-260054-iihgc5nr	107	41	leucine	leucine	NNP
cord-260054-iihgc5nr	107	42	)	)	-RRB-
cord-260054-iihgc5nr	107	43	,	,	,
cord-260054-iihgc5nr	107	44	polar	polar	JJ
cord-260054-iihgc5nr	107	45	(	(	-LRB-
cord-260054-iihgc5nr	107	46	serine	serine	NN
cord-260054-iihgc5nr	107	47	in	in	IN
cord-260054-iihgc5nr	107	48	2	2	CD
cord-260054-iihgc5nr	107	49	cases	case	NNS
cord-260054-iihgc5nr	107	50	)	)	-RRB-
cord-260054-iihgc5nr	107	51	or	or	CC
cord-260054-iihgc5nr	107	52	even	even	RB
cord-260054-iihgc5nr	107	53	charged	charge	VBN
cord-260054-iihgc5nr	107	54	(	(	-LRB-
cord-260054-iihgc5nr	107	55	aspartate	aspartate	NN
cord-260054-iihgc5nr	107	56	)	)	-RRB-
cord-260054-iihgc5nr	107	57	residues	residue	NNS
cord-260054-iihgc5nr	107	58	.	.	.
cord-260054-iihgc5nr	108	1	In	in	IN
cord-260054-iihgc5nr	108	2	addition	addition	NN
cord-260054-iihgc5nr	108	3	,	,	,
cord-260054-iihgc5nr	108	4	S940	S940	NNP
cord-260054-iihgc5nr	108	5	involves	involve	VBZ
cord-260054-iihgc5nr	108	6	its	-PRON-	PRP$
cord-260054-iihgc5nr	108	7	side	side	NN
cord-260054-iihgc5nr	108	8	-	-	HYPH
cord-260054-iihgc5nr	108	9	chain	chain	NN
cord-260054-iihgc5nr	108	10	in	in	IN
cord-260054-iihgc5nr	108	11	a	a	DT
cord-260054-iihgc5nr	108	12	H	h	NN
cord-260054-iihgc5nr	108	13	-	-	HYPH
cord-260054-iihgc5nr	108	14	bond	bond	NN
cord-260054-iihgc5nr	108	15	with	with	IN
cord-260054-iihgc5nr	108	16	the	the	DT
cord-260054-iihgc5nr	108	17	main	main	JJ
cord-260054-iihgc5nr	108	18	-	-	HYPH
cord-260054-iihgc5nr	108	19	chain	chain	NN
cord-260054-iihgc5nr	108	20	of	of	IN
cord-260054-iihgc5nr	108	21	D936	D936	NNS
cord-260054-iihgc5nr	108	22	,	,	,
cord-260054-iihgc5nr	108	23	4	4	CD
cord-260054-iihgc5nr	108	24	residues	residue	NNS
cord-260054-iihgc5nr	108	25	upstream	upstream	RB
cord-260054-iihgc5nr	108	26	.	.	.
cord-260054-iihgc5nr	109	1	The	the	DT
cord-260054-iihgc5nr	109	2	loss	loss	NN
cord-260054-iihgc5nr	109	3	of	of	IN
cord-260054-iihgc5nr	109	4	this	this	DT
cord-260054-iihgc5nr	109	5	H	h	NN
cord-260054-iihgc5nr	109	6	-	-	HYPH
cord-260054-iihgc5nr	109	7	bond	bond	NN
cord-260054-iihgc5nr	109	8	in	in	IN
cord-260054-iihgc5nr	109	9	the	the	DT
cord-260054-iihgc5nr	109	10	S940F	S940F	NNPS
cord-260054-iihgc5nr	109	11	mutant	mutant	NN
cord-260054-iihgc5nr	109	12	also	also	RB
cord-260054-iihgc5nr	109	13	points	point	VBZ
cord-260054-iihgc5nr	109	14	to	to	IN
cord-260054-iihgc5nr	109	15	a	a	DT
cord-260054-iihgc5nr	109	16	slight	slight	JJ
cord-260054-iihgc5nr	109	17	destabilization	destabilization	NN
cord-260054-iihgc5nr	109	18	of	of	IN
cord-260054-iihgc5nr	109	19	the	the	DT
cord-260054-iihgc5nr	109	20	pre	pre	JJ
cord-260054-iihgc5nr	109	21	-	-	JJ
cord-260054-iihgc5nr	109	22	fusion	fusion	JJ
cord-260054-iihgc5nr	109	23	conformation	conformation	NN
cord-260054-iihgc5nr	109	24	.	.	.
cord-260054-iihgc5nr	110	1	As	as	IN
cord-260054-iihgc5nr	110	2	for	for	IN
cord-260054-iihgc5nr	110	3	L938	L938	NNP
cord-260054-iihgc5nr	110	4	,	,	,
cord-260054-iihgc5nr	110	5	it	-PRON-	PRP
cord-260054-iihgc5nr	110	6	is	be	VBZ
cord-260054-iihgc5nr	110	7	buried	bury	VBN
cord-260054-iihgc5nr	110	8	in	in	IN
cord-260054-iihgc5nr	110	9	the	the	DT
cord-260054-iihgc5nr	110	10	prefusion	prefusion	NN
cord-260054-iihgc5nr	110	11	conformation	conformation	NN
cord-260054-iihgc5nr	110	12	,	,	,
cord-260054-iihgc5nr	110	13	pointing	point	VBG
cord-260054-iihgc5nr	110	14	towards	towards	IN
cord-260054-iihgc5nr	110	15	a	a	DT
cord-260054-iihgc5nr	110	16	three	three	CD
cord-260054-iihgc5nr	110	17	-	-	HYPH
cord-260054-iihgc5nr	110	18	stranded	strand	VBN
cord-260054-iihgc5nr	110	19	anti	anti	JJ
cord-260054-iihgc5nr	110	20	-	-	JJ
cord-260054-iihgc5nr	110	21	parallel	parallel	JJ
cord-260054-iihgc5nr	110	22	β	β	NN
cord-260054-iihgc5nr	110	23	-	-	HYPH
cord-260054-iihgc5nr	110	24	sheet	sheet	NN
cord-260054-iihgc5nr	110	25	made	make	VBN
cord-260054-iihgc5nr	110	26	of	of	IN
cord-260054-iihgc5nr	110	27	the	the	DT
cord-260054-iihgc5nr	110	28	S711-P728	S711-P728	NNP
cord-260054-iihgc5nr	110	29	segment	segment	NN
cord-260054-iihgc5nr	110	30	from	from	IN
cord-260054-iihgc5nr	110	31	the	the	DT
cord-260054-iihgc5nr	110	32	S1	S1	NNP
cord-260054-iihgc5nr	110	33	subunit	subunit	NN
cord-260054-iihgc5nr	110	34	and	and	CC
cord-260054-iihgc5nr	110	35	of	of	IN
cord-260054-iihgc5nr	110	36	the	the	DT
cord-260054-iihgc5nr	110	37	Y1047-P1053	y1047-p1053	NN
cord-260054-iihgc5nr	110	38	and	and	CC
cord-260054-iihgc5nr	110	39	G1059-A1078	G1059-A1078	NNP
cord-260054-iihgc5nr	110	40	segments	segment	NNS
cord-260054-iihgc5nr	110	41	from	from	IN
cord-260054-iihgc5nr	110	42	the	the	DT
cord-260054-iihgc5nr	110	43	S2	S2	NNP
cord-260054-iihgc5nr	110	44	subunit	subunit	NN
cord-260054-iihgc5nr	110	45	,	,	,
cord-260054-iihgc5nr	110	46	without	without	IN
cord-260054-iihgc5nr	110	47	directly	directly	RB
cord-260054-iihgc5nr	110	48	contacting	contact	VBG
cord-260054-iihgc5nr	110	49	it	-PRON-	PRP
cord-260054-iihgc5nr	111	1	(	(	-LRB-
cord-260054-iihgc5nr	111	2	distances	distance	NNS
cord-260054-iihgc5nr	111	3	above	above	IN
cord-260054-iihgc5nr	111	4	5	5	CD
cord-260054-iihgc5nr	111	5	Å	å	NN
cord-260054-iihgc5nr	111	6	)	)	-RRB-
cord-260054-iihgc5nr	111	7	.	.	.
cord-260054-iihgc5nr	112	1	It	-PRON-	PRP
cord-260054-iihgc5nr	112	2	can	can	MD
cord-260054-iihgc5nr	112	3	also	also	RB
cord-260054-iihgc5nr	112	4	be	be	VB
cord-260054-iihgc5nr	112	5	modelled	model	VBN
cord-260054-iihgc5nr	112	6	as	as	IN
cord-260054-iihgc5nr	112	7	a	a	DT
cord-260054-iihgc5nr	112	8	large	large	JJ
cord-260054-iihgc5nr	112	9	phenylalanine	phenylalanine	NN
cord-260054-iihgc5nr	112	10	without	without	IN
cord-260054-iihgc5nr	112	11	causing	cause	VBG
cord-260054-iihgc5nr	112	12	sterical	sterical	JJ
cord-260054-iihgc5nr	112	13	strain	strain	NN
cord-260054-iihgc5nr	112	14	.	.	.
cord-260054-iihgc5nr	113	1	Upon	upon	IN
cord-260054-iihgc5nr	113	2	mutation	mutation	NN
cord-260054-iihgc5nr	113	3	,	,	,
cord-260054-iihgc5nr	113	4	it	-PRON-	PRP
cord-260054-iihgc5nr	113	5	seems	seem	VBZ
cord-260054-iihgc5nr	113	6	to	to	TO
cord-260054-iihgc5nr	113	7	optimize	optimize	VB
cord-260054-iihgc5nr	113	8	the	the	DT
cord-260054-iihgc5nr	113	9	hydrophobic	hydrophobic	JJ
cord-260054-iihgc5nr	113	10	interactions	interaction	NNS
cord-260054-iihgc5nr	113	11	with	with	IN
cord-260054-iihgc5nr	113	12	the	the	DT
cord-260054-iihgc5nr	113	13	neighboring	neighboring	NN
cord-260054-iihgc5nr	113	14	residues	residue	NNS
cord-260054-iihgc5nr	113	15	,	,	,
cord-260054-iihgc5nr	113	16	especially	especially	RB
cord-260054-iihgc5nr	113	17	I726	I726	NNP
cord-260054-iihgc5nr	113	18	and	and	CC
cord-260054-iihgc5nr	113	19	A944	A944	NNP
cord-260054-iihgc5nr	113	20	.	.	.
cord-260054-iihgc5nr	114	1	Finally	finally	RB
cord-260054-iihgc5nr	114	2	,	,	,
cord-260054-iihgc5nr	114	3	S943	S943	NNP
cord-260054-iihgc5nr	114	4	is	be	VBZ
cord-260054-iihgc5nr	114	5	located	locate	VBN
cord-260054-iihgc5nr	114	6	on	on	IN
cord-260054-iihgc5nr	114	7	a	a	DT
cord-260054-iihgc5nr	114	8	turn	turn	NN
cord-260054-iihgc5nr	114	9	immediately	immediately	RB
cord-260054-iihgc5nr	114	10	downstream	downstream	VBP
cord-260054-iihgc5nr	114	11	the	the	DT
cord-260054-iihgc5nr	114	12	helical	helical	JJ
cord-260054-iihgc5nr	114	13	segment	segment	NN
cord-260054-iihgc5nr	114	14	hosting	host	VBG
cord-260054-iihgc5nr	114	15	the	the	DT
cord-260054-iihgc5nr	114	16	above	above	JJ
cord-260054-iihgc5nr	114	17	five	five	CD
cord-260054-iihgc5nr	114	18	mutations	mutation	NNS
cord-260054-iihgc5nr	114	19	,	,	,
cord-260054-iihgc5nr	114	20	between	between	IN
cord-260054-iihgc5nr	114	21	the	the	DT
cord-260054-iihgc5nr	114	22	second	second	JJ
cord-260054-iihgc5nr	114	23	and	and	CC
cord-260054-iihgc5nr	114	24	third	third	JJ
cord-260054-iihgc5nr	114	25	helical	helical	JJ
cord-260054-iihgc5nr	114	26	segments	segment	NNS
cord-260054-iihgc5nr	114	27	.	.	.
cord-260054-iihgc5nr	115	1	The	the	DT
cord-260054-iihgc5nr	115	2	wild	wild	JJ
cord-260054-iihgc5nr	115	3	-	-	HYPH
cord-260054-iihgc5nr	115	4	type	type	NN
cord-260054-iihgc5nr	115	5	residue	residue	NN
cord-260054-iihgc5nr	115	6	S943	S943	NNP
cord-260054-iihgc5nr	115	7	features	feature	VBZ
cord-260054-iihgc5nr	115	8	φ	φ	NN
cord-260054-iihgc5nr	115	9	and	and	CC
cord-260054-iihgc5nr	115	10	ψ	ψ	LS
cord-260054-iihgc5nr	115	11	dihedral	dihedral	JJ
cord-260054-iihgc5nr	115	12	angles	angle	NNS
cord-260054-iihgc5nr	115	13	of	of	IN
cord-260054-iihgc5nr	115	14	58.5	58.5	CD
cord-260054-iihgc5nr	115	15	°	°	NNS
cord-260054-iihgc5nr	115	16	and	and	CC
cord-260054-iihgc5nr	115	17	24.5	24.5	CD
cord-260054-iihgc5nr	115	18	°	°	NNS
cord-260054-iihgc5nr	115	19	,	,	,
cord-260054-iihgc5nr	115	20	respectively	respectively	RB
cord-260054-iihgc5nr	115	21	,	,	,
cord-260054-iihgc5nr	115	22	which	which	WDT
cord-260054-iihgc5nr	115	23	fall	fall	VBP
cord-260054-iihgc5nr	115	24	in	in	IN
cord-260054-iihgc5nr	115	25	an	an	DT
cord-260054-iihgc5nr	115	26	unfavourable	unfavourable	JJ
cord-260054-iihgc5nr	115	27	region	region	NN
cord-260054-iihgc5nr	115	28	for	for	IN
cord-260054-iihgc5nr	115	29	prolines	proline	NNS
cord-260054-iihgc5nr	115	30	.	.	.
cord-260054-iihgc5nr	116	1	In	in	IN
cord-260054-iihgc5nr	116	2	the	the	DT
cord-260054-iihgc5nr	116	3	S943P	S943P	NNP
cord-260054-iihgc5nr	116	4	model	model	NN
cord-260054-iihgc5nr	116	5	we	-PRON-	PRP
cord-260054-iihgc5nr	116	6	generated	generate	VBD
cord-260054-iihgc5nr	116	7	,	,	,
cord-260054-iihgc5nr	116	8	the	the	DT
cord-260054-iihgc5nr	116	9	P943	P943	NNP
cord-260054-iihgc5nr	116	10	φ	φ	NN
cord-260054-iihgc5nr	116	11	and	and	CC
cord-260054-iihgc5nr	116	12	ψ	ψ	NN
cord-260054-iihgc5nr	116	13	dihedrals	dihedral	NNS
cord-260054-iihgc5nr	116	14	assume	assume	VBP
cord-260054-iihgc5nr	116	15	the	the	DT
cord-260054-iihgc5nr	116	16	values	value	NNS
cord-260054-iihgc5nr	116	17	of	of	IN
cord-260054-iihgc5nr	116	18	3.0	3.0	CD
cord-260054-iihgc5nr	116	19	°	°	NNS
cord-260054-iihgc5nr	116	20	and	and	CC
cord-260054-iihgc5nr	116	21	68.2	68.2	CD
cord-260054-iihgc5nr	116	22	°	°	NNS
cord-260054-iihgc5nr	116	23	,	,	,
cord-260054-iihgc5nr	116	24	placing	place	VBG
cord-260054-iihgc5nr	116	25	the	the	DT
cord-260054-iihgc5nr	116	26	residue	residue	NN
cord-260054-iihgc5nr	116	27	in	in	IN
cord-260054-iihgc5nr	116	28	an	an	DT
cord-260054-iihgc5nr	116	29	outlier	outlier	JJ
cord-260054-iihgc5nr	116	30	region	region	NN
cord-260054-iihgc5nr	116	31	(	(	-LRB-
cord-260054-iihgc5nr	116	32	39	39	CD
cord-260054-iihgc5nr	116	33	)	)	-RRB-
cord-260054-iihgc5nr	116	34	.	.	.
cord-260054-iihgc5nr	117	1	The	the	DT
cord-260054-iihgc5nr	117	2	favoured	favoured	JJ
cord-260054-iihgc5nr	117	3	φ	φ	NN
cord-260054-iihgc5nr	117	4	angle	angle	NN
cord-260054-iihgc5nr	117	5	for	for	IN
cord-260054-iihgc5nr	117	6	prolines	proline	NNS
cord-260054-iihgc5nr	117	7	is	be	VBZ
cord-260054-iihgc5nr	117	8	indeed	indeed	RB
cord-260054-iihgc5nr	117	9	restricted	restricted	JJ
cord-260054-iihgc5nr	117	10	to	to	IN
cord-260054-iihgc5nr	117	11	the	the	DT
cord-260054-iihgc5nr	117	12	value	value	NN
cord-260054-iihgc5nr	117	13	of	of	IN
cord-260054-iihgc5nr	117	14	-63	-63	NNP
cord-260054-iihgc5nr	117	15	±	±	NNP
cord-260054-iihgc5nr	117	16	15	15	CD
cord-260054-iihgc5nr	117	17	°	°	NNS
cord-260054-iihgc5nr	117	18	,	,	,
cord-260054-iihgc5nr	117	19	(	(	-LRB-
cord-260054-iihgc5nr	117	20	40	40	CD
cord-260054-iihgc5nr	117	21	)	)	-RRB-
cord-260054-iihgc5nr	117	22	characteristic	characteristic	NN
cord-260054-iihgc5nr	117	23	of	of	IN
cord-260054-iihgc5nr	117	24	α	α	NN
cord-260054-iihgc5nr	117	25	-	-	HYPH
cord-260054-iihgc5nr	117	26	helices	helix	NNS
cord-260054-iihgc5nr	117	27	.	.	.
cord-260054-iihgc5nr	118	1	A	a	DT
cord-260054-iihgc5nr	118	2	proline	proline	NN
cord-260054-iihgc5nr	118	3	at	at	IN
cord-260054-iihgc5nr	118	4	such	such	PDT
cord-260054-iihgc5nr	118	5	a	a	DT
cord-260054-iihgc5nr	118	6	position	position	NN
cord-260054-iihgc5nr	118	7	would	would	MD
cord-260054-iihgc5nr	118	8	therefore	therefore	RB
cord-260054-iihgc5nr	118	9	introduce	introduce	VB
cord-260054-iihgc5nr	118	10	an	an	DT
cord-260054-iihgc5nr	118	11	anomaly	anomaly	NN
cord-260054-iihgc5nr	118	12	in	in	IN
cord-260054-iihgc5nr	118	13	the	the	DT
cord-260054-iihgc5nr	118	14	pre	pre	JJ
cord-260054-iihgc5nr	118	15	-	-	JJ
cord-260054-iihgc5nr	118	16	fusion	fusion	JJ
cord-260054-iihgc5nr	118	17	conformation	conformation	NN
cord-260054-iihgc5nr	118	18	,	,	,
cord-260054-iihgc5nr	118	19	while	while	IN
cord-260054-iihgc5nr	118	20	strongly	strongly	RB
cord-260054-iihgc5nr	118	21	promoting	promote	VBG
cord-260054-iihgc5nr	118	22	the	the	DT
cord-260054-iihgc5nr	118	23	transition	transition	NN
cord-260054-iihgc5nr	118	24	to	to	IN
cord-260054-iihgc5nr	118	25	the	the	DT
cord-260054-iihgc5nr	118	26	post	post	JJ
cord-260054-iihgc5nr	118	27	-	-	JJ
cord-260054-iihgc5nr	118	28	fusion	fusion	JJ
cord-260054-iihgc5nr	118	29	single	single	JJ
cord-260054-iihgc5nr	118	30	continuous	continuous	JJ
cord-260054-iihgc5nr	118	31	helical	helical	JJ
cord-260054-iihgc5nr	118	32	conformation	conformation	NN
cord-260054-iihgc5nr	118	33	.	.	.
cord-260054-iihgc5nr	119	1	It	-PRON-	PRP
cord-260054-iihgc5nr	119	2	is	be	VBZ
cord-260054-iihgc5nr	119	3	also	also	RB
cord-260054-iihgc5nr	119	4	worth	worth	JJ
cord-260054-iihgc5nr	119	5	noticing	notice	VBG
cord-260054-iihgc5nr	119	6	that	that	IN
cord-260054-iihgc5nr	119	7	this	this	DT
cord-260054-iihgc5nr	119	8	would	would	MD
cord-260054-iihgc5nr	119	9	be	be	VB
cord-260054-iihgc5nr	119	10	the	the	DT
cord-260054-iihgc5nr	119	11	only	only	JJ
cord-260054-iihgc5nr	119	12	mutation	mutation	NN
cord-260054-iihgc5nr	119	13	among	among	IN
cord-260054-iihgc5nr	119	14	those	those	DT
cord-260054-iihgc5nr	119	15	we	-PRON-	PRP
cord-260054-iihgc5nr	119	16	identified	identify	VBD
cord-260054-iihgc5nr	119	17	so	so	RB
cord-260054-iihgc5nr	119	18	far	far	RB
cord-260054-iihgc5nr	119	19	,	,	,
cord-260054-iihgc5nr	119	20	introducing	introduce	VBG
cord-260054-iihgc5nr	119	21	a	a	DT
cord-260054-iihgc5nr	119	22	proline	proline	NN
cord-260054-iihgc5nr	119	23	residue	residue	NN
cord-260054-iihgc5nr	119	24	in	in	IN
cord-260054-iihgc5nr	119	25	the	the	DT
cord-260054-iihgc5nr	119	26	SARS	SARS	NNP
cord-260054-iihgc5nr	119	27	-	-	HYPH
cord-260054-iihgc5nr	119	28	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	119	29	S	S	NNP
cord-260054-iihgc5nr	119	30	protein	protein	NN
cord-260054-iihgc5nr	119	31	(	(	-LRB-
cord-260054-iihgc5nr	119	32	Table	Table	NNP
cord-260054-iihgc5nr	119	33	S1	S1	NNP
cord-260054-iihgc5nr	119	34	)	)	-RRB-
cord-260054-iihgc5nr	119	35	.	.	.
cord-260054-iihgc5nr	120	1	In	in	IN
cord-260054-iihgc5nr	120	2	light	light	NN
cord-260054-iihgc5nr	120	3	of	of	IN
cord-260054-iihgc5nr	120	4	the	the	DT
cord-260054-iihgc5nr	120	5	analysis	analysis	NN
cord-260054-iihgc5nr	120	6	of	of	IN
cord-260054-iihgc5nr	120	7	the	the	DT
cord-260054-iihgc5nr	120	8	GISAID	GISAID	NNP
cord-260054-iihgc5nr	121	1	May	May	NNP
cord-260054-iihgc5nr	121	2	29	29	CD
cord-260054-iihgc5nr	121	3	th	th	XX
cord-260054-iihgc5nr	121	4	updated	update	VBN
cord-260054-iihgc5nr	121	5	,	,	,
cord-260054-iihgc5nr	121	6	we	-PRON-	PRP
cord-260054-iihgc5nr	121	7	also	also	RB
cord-260054-iihgc5nr	121	8	modelled	model	VBD
cord-260054-iihgc5nr	121	9	the	the	DT
cord-260054-iihgc5nr	121	10	S943I	S943I	NNP
cord-260054-iihgc5nr	121	11	mutation	mutation	NN
cord-260054-iihgc5nr	121	12	.	.	.
cord-260054-iihgc5nr	122	1	Being	be	VBG
cord-260054-iihgc5nr	122	2	isoleucine	isoleucine	NN
cord-260054-iihgc5nr	122	3	compatible	compatible	JJ
cord-260054-iihgc5nr	122	4	with	with	IN
cord-260054-iihgc5nr	122	5	the	the	DT
cord-260054-iihgc5nr	122	6	S943	s943	JJ
cord-260054-iihgc5nr	122	7	dihedral	dihedral	JJ
cord-260054-iihgc5nr	122	8	values	value	NNS
cord-260054-iihgc5nr	122	9	,	,	,
cord-260054-iihgc5nr	122	10	this	this	DT
cord-260054-iihgc5nr	122	11	mutation	mutation	NN
cord-260054-iihgc5nr	122	12	does	do	VBZ
cord-260054-iihgc5nr	122	13	not	not	RB
cord-260054-iihgc5nr	122	14	result	result	VB
cord-260054-iihgc5nr	122	15	in	in	IN
cord-260054-iihgc5nr	122	16	any	any	DT
cord-260054-iihgc5nr	122	17	structural	structural	JJ
cord-260054-iihgc5nr	122	18	strain	strain	NN
cord-260054-iihgc5nr	122	19	.	.	.
cord-260054-iihgc5nr	123	1	When	when	WRB
cord-260054-iihgc5nr	123	2	looking	look	VBG
cord-260054-iihgc5nr	123	3	at	at	IN
cord-260054-iihgc5nr	123	4	the	the	DT
cord-260054-iihgc5nr	123	5	post	post	JJ
cord-260054-iihgc5nr	123	6	-	-	JJ
cord-260054-iihgc5nr	123	7	fusion	fusion	JJ
cord-260054-iihgc5nr	123	8	conformation	conformation	NN
cord-260054-iihgc5nr	123	9	of	of	IN
cord-260054-iihgc5nr	123	10	the	the	DT
cord-260054-iihgc5nr	123	11	SARS	SARS	NNP
cord-260054-iihgc5nr	123	12	-	-	HYPH
cord-260054-iihgc5nr	123	13	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	123	14	spike	spike	NN
cord-260054-iihgc5nr	123	15	protein	protein	NN
cord-260054-iihgc5nr	123	16	S2	s2	NN
cord-260054-iihgc5nr	123	17	subunit	subunit	NN
cord-260054-iihgc5nr	123	18	,	,	,
cord-260054-iihgc5nr	123	19	these	these	DT
cord-260054-iihgc5nr	123	20	mutations	mutation	NNS
cord-260054-iihgc5nr	123	21	appear	appear	VBP
cord-260054-iihgc5nr	123	22	more	more	RBR
cord-260054-iihgc5nr	123	23	revealing	revealing	JJ
cord-260054-iihgc5nr	123	24	.	.	.
cord-260054-iihgc5nr	124	1	Three	three	CD
cord-260054-iihgc5nr	124	2	of	of	IN
cord-260054-iihgc5nr	124	3	the	the	DT
cord-260054-iihgc5nr	124	4	wild	wild	JJ
cord-260054-iihgc5nr	124	5	-	-	HYPH
cord-260054-iihgc5nr	124	6	type	type	NN
cord-260054-iihgc5nr	124	7	residues	residue	NNS
cord-260054-iihgc5nr	124	8	,	,	,
cord-260054-iihgc5nr	124	9	S929	s929	JJ
cord-260054-iihgc5nr	124	10	,	,	,
cord-260054-iihgc5nr	124	11	D936	D936	VBZ
cord-260054-iihgc5nr	124	12	and	and	CC
cord-260054-iihgc5nr	124	13	S943	S943	NNP
cord-260054-iihgc5nr	124	14	,	,	,
cord-260054-iihgc5nr	124	15	are	be	VBP
cord-260054-iihgc5nr	124	16	indeed	indeed	RB
cord-260054-iihgc5nr	124	17	engaged	engage	VBN
cord-260054-iihgc5nr	124	18	in	in	IN
cord-260054-iihgc5nr	124	19	side	side	NN
cord-260054-iihgc5nr	124	20	-	-	HYPH
cord-260054-iihgc5nr	124	21	chain	chain	NN
cord-260054-iihgc5nr	124	22	to	to	IN
cord-260054-iihgc5nr	124	23	side	side	NN
cord-260054-iihgc5nr	124	24	-	-	HYPH
cord-260054-iihgc5nr	124	25	chain	chain	NN
cord-260054-iihgc5nr	124	26	H	h	NN
cord-260054-iihgc5nr	124	27	-	-	HYPH
cord-260054-iihgc5nr	124	28	bonds	bond	NNS
cord-260054-iihgc5nr	124	29	with	with	IN
cord-260054-iihgc5nr	124	30	the	the	DT
cord-260054-iihgc5nr	124	31	HR2	HR2	NNP
cord-260054-iihgc5nr	124	32	segment	segment	NN
cord-260054-iihgc5nr	124	33	of	of	IN
cord-260054-iihgc5nr	124	34	an	an	DT
cord-260054-iihgc5nr	124	35	adjacent	adjacent	JJ
cord-260054-iihgc5nr	124	36	monomer	monomer	NN
cord-260054-iihgc5nr	124	37	.	.	.
cord-260054-iihgc5nr	125	1	In	in	IN
cord-260054-iihgc5nr	125	2	particular	particular	JJ
cord-260054-iihgc5nr	125	3	,	,	,
cord-260054-iihgc5nr	125	4	S929	s929	JJ
cord-260054-iihgc5nr	125	5	,	,	,
cord-260054-iihgc5nr	125	6	D936	D936	NNS
cord-260054-iihgc5nr	125	7	and	and	CC
cord-260054-iihgc5nr	125	8	S943	s943	JJ
cord-260054-iihgc5nr	125	9	(	(	-LRB-
cord-260054-iihgc5nr	125	10	HR1	HR1	NNP
cord-260054-iihgc5nr	125	11	on	on	IN
cord-260054-iihgc5nr	125	12	Chain	Chain	NNP
cord-260054-iihgc5nr	125	13	A	A	NNP
cord-260054-iihgc5nr	125	14	)	)	-RRB-
cord-260054-iihgc5nr	125	15	are	be	VBP
cord-260054-iihgc5nr	125	16	H	h	NN
cord-260054-iihgc5nr	125	17	-	-	HYPH
cord-260054-iihgc5nr	125	18	bonded	bond	VBN
cord-260054-iihgc5nr	125	19	to	to	IN
cord-260054-iihgc5nr	125	20	S1196	S1196	NNP
cord-260054-iihgc5nr	125	21	,	,	,
cord-260054-iihgc5nr	125	22	R1185	R1185	NNP
cord-260054-iihgc5nr	125	23	and	and	CC
cord-260054-iihgc5nr	125	24	E1182	E1182	NNP
cord-260054-iihgc5nr	125	25	,	,	,
cord-260054-iihgc5nr	125	26	respectively	respectively	RB
cord-260054-iihgc5nr	125	27	(	(	-LRB-
cord-260054-iihgc5nr	125	28	HR2	HR2	NNP
cord-260054-iihgc5nr	125	29	on	on	IN
cord-260054-iihgc5nr	125	30	Chain	Chain	NNP
cord-260054-iihgc5nr	125	31	C	C	NNP
cord-260054-iihgc5nr	125	32	,	,	,
cord-260054-iihgc5nr	125	33	Figure	figure	NN
cord-260054-iihgc5nr	125	34	3	3	CD
cord-260054-iihgc5nr	125	35	)	)	-RRB-
cord-260054-iihgc5nr	125	36	.	.	.
cord-260054-iihgc5nr	126	1	These	these	DT
cord-260054-iihgc5nr	126	2	are	be	VBP
cord-260054-iihgc5nr	126	3	all	all	RB
cord-260054-iihgc5nr	126	4	strong	strong	JJ
cord-260054-iihgc5nr	126	5	H	h	NN
cord-260054-iihgc5nr	126	6	-	-	HYPH
cord-260054-iihgc5nr	126	7	bonds	bond	NNS
cord-260054-iihgc5nr	126	8	,	,	,
cord-260054-iihgc5nr	126	9	especially	especially	RB
cord-260054-iihgc5nr	126	10	the	the	DT
cord-260054-iihgc5nr	126	11	one	one	CD
cord-260054-iihgc5nr	126	12	between	between	IN
cord-260054-iihgc5nr	126	13	S943	S943	NNP
cord-260054-iihgc5nr	126	14	and	and	CC
cord-260054-iihgc5nr	126	15	E1182	E1182	NNP
cord-260054-iihgc5nr	126	16	,	,	,
cord-260054-iihgc5nr	126	17	involving	involve	VBG
cord-260054-iihgc5nr	126	18	a	a	DT
cord-260054-iihgc5nr	126	19	negatively	negatively	RB
cord-260054-iihgc5nr	126	20	charged	charge	VBN
cord-260054-iihgc5nr	126	21	residue	residue	NN
cord-260054-iihgc5nr	126	22	,	,	,
cord-260054-iihgc5nr	126	23	and	and	CC
cord-260054-iihgc5nr	126	24	the	the	DT
cord-260054-iihgc5nr	126	25	one	one	CD
cord-260054-iihgc5nr	126	26	between	between	IN
cord-260054-iihgc5nr	126	27	D936	D936	NNS
cord-260054-iihgc5nr	126	28	and	and	CC
cord-260054-iihgc5nr	126	29	R1185	R1185	NNP
cord-260054-iihgc5nr	126	30	,	,	,
cord-260054-iihgc5nr	126	31	being	be	VBG
cord-260054-iihgc5nr	126	32	actually	actually	RB
cord-260054-iihgc5nr	126	33	a	a	DT
cord-260054-iihgc5nr	126	34	salt	salt	NN
cord-260054-iihgc5nr	126	35	bridge	bridge	NN
cord-260054-iihgc5nr	126	36	(	(	-LRB-
cord-260054-iihgc5nr	126	37	estimated	estimate	VBN
cord-260054-iihgc5nr	126	38	to	to	TO
cord-260054-iihgc5nr	126	39	contribute	contribute	VB
cord-260054-iihgc5nr	126	40	an	an	DT
cord-260054-iihgc5nr	126	41	additional	additional	JJ
cord-260054-iihgc5nr	126	42	3	3	CD
cord-260054-iihgc5nr	126	43	-	-	SYM
cord-260054-iihgc5nr	126	44	5	5	CD
cord-260054-iihgc5nr	126	45	kcal	kcal	NNP
cord-260054-iihgc5nr	126	46	/	/	SYM
cord-260054-iihgc5nr	126	47	mol	mol	NN
cord-260054-iihgc5nr	126	48	to	to	IN
cord-260054-iihgc5nr	126	49	the	the	DT
cord-260054-iihgc5nr	126	50	free	free	JJ
cord-260054-iihgc5nr	126	51	energy	energy	NN
cord-260054-iihgc5nr	126	52	of	of	IN
cord-260054-iihgc5nr	126	53	protein	protein	NN
cord-260054-iihgc5nr	126	54	stability	stability	NN
cord-260054-iihgc5nr	126	55	as	as	IN
cord-260054-iihgc5nr	126	56	compare	compare	VBP
cord-260054-iihgc5nr	126	57	to	to	IN
cord-260054-iihgc5nr	126	58	a	a	DT
cord-260054-iihgc5nr	126	59	neutral	neutral	JJ
cord-260054-iihgc5nr	126	60	H	h	NN
cord-260054-iihgc5nr	126	61	-	-	HYPH
cord-260054-iihgc5nr	126	62	bond	bond	NN
cord-260054-iihgc5nr	126	63	(	(	-LRB-
cord-260054-iihgc5nr	126	64	41	41	CD
cord-260054-iihgc5nr	126	65	)	)	-RRB-
cord-260054-iihgc5nr	126	66	)	)	-RRB-
cord-260054-iihgc5nr	126	67	.	.	.
cord-260054-iihgc5nr	127	1	All	all	PDT
cord-260054-iihgc5nr	127	2	these	these	DT
cord-260054-iihgc5nr	127	3	three	three	CD
cord-260054-iihgc5nr	127	4	H	h	NN
cord-260054-iihgc5nr	127	5	-	-	HYPH
cord-260054-iihgc5nr	127	6	bonds	bond	NNS
cord-260054-iihgc5nr	127	7	are	be	VBP
cord-260054-iihgc5nr	127	8	lost	lose	VBN
cord-260054-iihgc5nr	127	9	upon	upon	IN
cord-260054-iihgc5nr	127	10	mutation	mutation	NN
cord-260054-iihgc5nr	127	11	,	,	,
cord-260054-iihgc5nr	127	12	which	which	WDT
cord-260054-iihgc5nr	127	13	points	point	VBZ
cord-260054-iihgc5nr	127	14	to	to	IN
cord-260054-iihgc5nr	127	15	a	a	DT
cord-260054-iihgc5nr	127	16	weakening	weakening	NN
cord-260054-iihgc5nr	127	17	of	of	IN
cord-260054-iihgc5nr	127	18	the	the	DT
cord-260054-iihgc5nr	127	19	post	post	JJ
cord-260054-iihgc5nr	127	20	-	-	JJ
cord-260054-iihgc5nr	127	21	fusion	fusion	JJ
cord-260054-iihgc5nr	127	22	assembly	assembly	NN
cord-260054-iihgc5nr	127	23	.	.	.
cord-260054-iihgc5nr	128	1	Of	of	IN
cord-260054-iihgc5nr	128	2	the	the	DT
cord-260054-iihgc5nr	128	3	remaining	remain	VBG
cord-260054-iihgc5nr	128	4	three	three	CD
cord-260054-iihgc5nr	128	5	mutations	mutation	NNS
cord-260054-iihgc5nr	128	6	,	,	,
cord-260054-iihgc5nr	128	7	S939F	S939F	NNP
cord-260054-iihgc5nr	128	8	is	be	VBZ
cord-260054-iihgc5nr	128	9	completely	completely	RB
cord-260054-iihgc5nr	128	10	exposed	expose	VBN
cord-260054-iihgc5nr	128	11	to	to	IN
cord-260054-iihgc5nr	128	12	the	the	DT
cord-260054-iihgc5nr	128	13	solvent	solvent	NN
cord-260054-iihgc5nr	128	14	and	and	CC
cord-260054-iihgc5nr	128	15	therefore	therefore	RB
cord-260054-iihgc5nr	128	16	,	,	,
cord-260054-iihgc5nr	128	17	like	like	UH
cord-260054-iihgc5nr	128	18	in	in	IN
cord-260054-iihgc5nr	128	19	the	the	DT
cord-260054-iihgc5nr	128	20	pre	pre	JJ
cord-260054-iihgc5nr	128	21	-	-	JJ
cord-260054-iihgc5nr	128	22	fusion	fusion	JJ
cord-260054-iihgc5nr	128	23	conformation	conformation	NN
cord-260054-iihgc5nr	128	24	,	,	,
cord-260054-iihgc5nr	128	25	expected	expect	VBN
cord-260054-iihgc5nr	128	26	to	to	TO
cord-260054-iihgc5nr	128	27	act	act	VB
cord-260054-iihgc5nr	128	28	unfavourable	unfavourable	JJ
cord-260054-iihgc5nr	128	29	on	on	IN
cord-260054-iihgc5nr	128	30	the	the	DT
cord-260054-iihgc5nr	128	31	protein	protein	NN
cord-260054-iihgc5nr	128	32	solvation	solvation	NN
cord-260054-iihgc5nr	128	33	energy	energy	NN
cord-260054-iihgc5nr	128	34	.	.	.
cord-260054-iihgc5nr	129	1	On	on	IN
cord-260054-iihgc5nr	129	2	the	the	DT
cord-260054-iihgc5nr	129	3	contrary	contrary	NN
cord-260054-iihgc5nr	129	4	,	,	,
cord-260054-iihgc5nr	129	5	in	in	IN
cord-260054-iihgc5nr	129	6	case	case	NN
cord-260054-iihgc5nr	129	7	of	of	IN
cord-260054-iihgc5nr	129	8	L938F	L938F	NNP
cord-260054-iihgc5nr	129	9	and	and	CC
cord-260054-iihgc5nr	129	10	S940F	S940F	NNP
cord-260054-iihgc5nr	129	11	,	,	,
cord-260054-iihgc5nr	129	12	which	which	WDT
cord-260054-iihgc5nr	129	13	are	be	VBP
cord-260054-iihgc5nr	129	14	substantially	substantially	RB
cord-260054-iihgc5nr	129	15	buried	bury	VBN
cord-260054-iihgc5nr	129	16	within	within	IN
cord-260054-iihgc5nr	129	17	the	the	DT
cord-260054-iihgc5nr	129	18	structure	structure	NN
cord-260054-iihgc5nr	129	19	,	,	,
cord-260054-iihgc5nr	129	20	mutation	mutation	NN
cord-260054-iihgc5nr	129	21	to	to	IN
cord-260054-iihgc5nr	129	22	a	a	DT
cord-260054-iihgc5nr	129	23	large	large	JJ
cord-260054-iihgc5nr	129	24	aromatic	aromatic	JJ
cord-260054-iihgc5nr	129	25	phenylalanine	phenylalanine	NN
cord-260054-iihgc5nr	129	26	seems	seem	VBZ
cord-260054-iihgc5nr	129	27	even	even	RB
cord-260054-iihgc5nr	129	28	to	to	TO
cord-260054-iihgc5nr	129	29	optimize	optimize	VB
cord-260054-iihgc5nr	129	30	the	the	DT
cord-260054-iihgc5nr	129	31	network	network	NN
cord-260054-iihgc5nr	129	32	of	of	IN
cord-260054-iihgc5nr	129	33	the	the	DT
cord-260054-iihgc5nr	129	34	hydrophobic	hydrophobic	JJ
cord-260054-iihgc5nr	129	35	interactions	interaction	NNS
cord-260054-iihgc5nr	129	36	;	;	:
cord-260054-iihgc5nr	129	37	in	in	IN
cord-260054-iihgc5nr	129	38	case	case	NN
cord-260054-iihgc5nr	129	39	of	of	IN
cord-260054-iihgc5nr	129	40	F940	f940	CD
cord-260054-iihgc5nr	129	41	,	,	,
cord-260054-iihgc5nr	129	42	with	with	IN
cord-260054-iihgc5nr	129	43	the	the	DT
cord-260054-iihgc5nr	129	44	aliphatic	aliphatic	JJ
cord-260054-iihgc5nr	129	45	parts	part	NNS
cord-260054-iihgc5nr	129	46	of	of	IN
cord-260054-iihgc5nr	129	47	the	the	DT
cord-260054-iihgc5nr	129	48	side	side	NN
cord-260054-iihgc5nr	129	49	-	-	HYPH
cord-260054-iihgc5nr	129	50	chains	chain	NNS
cord-260054-iihgc5nr	129	51	of	of	IN
cord-260054-iihgc5nr	129	52	E1182	E1182	NNP
cord-260054-iihgc5nr	129	53	and	and	CC
cord-260054-iihgc5nr	129	54	R1185	R1185	NNP
cord-260054-iihgc5nr	129	55	on	on	IN
cord-260054-iihgc5nr	129	56	an	an	DT
cord-260054-iihgc5nr	129	57	adjacent	adjacent	JJ
cord-260054-iihgc5nr	129	58	monomer	monomer	NN
cord-260054-iihgc5nr	129	59	,	,	,
cord-260054-iihgc5nr	129	60	and	and	CC
cord-260054-iihgc5nr	129	61	,	,	,
cord-260054-iihgc5nr	129	62	in	in	IN
cord-260054-iihgc5nr	129	63	case	case	NN
cord-260054-iihgc5nr	129	64	of	of	IN
cord-260054-iihgc5nr	129	65	F938	F938	NNP
cord-260054-iihgc5nr	129	66	,	,	,
cord-260054-iihgc5nr	129	67	with	with	IN
cord-260054-iihgc5nr	129	68	V1189	V1189	NNP
cord-260054-iihgc5nr	129	69	and	and	CC
cord-260054-iihgc5nr	129	70	A1190	A1190	NNP
cord-260054-iihgc5nr	129	71	on	on	IN
cord-260054-iihgc5nr	129	72	the	the	DT
cord-260054-iihgc5nr	129	73	same	same	JJ
cord-260054-iihgc5nr	129	74	monomer	monomer	NN
cord-260054-iihgc5nr	129	75	and	and	CC
cord-260054-iihgc5nr	129	76	with	with	IN
cord-260054-iihgc5nr	129	77	other	other	JJ
cord-260054-iihgc5nr	129	78	F938	f938	CD
cord-260054-iihgc5nr	129	79	residues	residue	NNS
cord-260054-iihgc5nr	129	80	on	on	IN
cord-260054-iihgc5nr	129	81	both	both	CC
cord-260054-iihgc5nr	129	82	the	the	DT
cord-260054-iihgc5nr	129	83	adjacent	adjacent	JJ
cord-260054-iihgc5nr	129	84	monomers	monomer	NNS
cord-260054-iihgc5nr	129	85	.	.	.
cord-260054-iihgc5nr	130	1	When	when	WRB
cord-260054-iihgc5nr	130	2	comparing	compare	VBG
cord-260054-iihgc5nr	130	3	the	the	DT
cord-260054-iihgc5nr	130	4	effect	effect	NN
cord-260054-iihgc5nr	130	5	of	of	IN
cord-260054-iihgc5nr	130	6	the	the	DT
cord-260054-iihgc5nr	130	7	mutations	mutation	NNS
cord-260054-iihgc5nr	130	8	on	on	IN
cord-260054-iihgc5nr	130	9	the	the	DT
cord-260054-iihgc5nr	130	10	pre	pre	NN
cord-260054-iihgc5nr	130	11	-	-	JJ
cord-260054-iihgc5nr	130	12	and	and	CC
cord-260054-iihgc5nr	130	13	post	post	JJ
cord-260054-iihgc5nr	130	14	-	-	JJ
cord-260054-iihgc5nr	130	15	fusion	fusion	JJ
cord-260054-iihgc5nr	130	16	structures	structure	NNS
cord-260054-iihgc5nr	130	17	,	,	,
cord-260054-iihgc5nr	130	18	it	-PRON-	PRP
cord-260054-iihgc5nr	130	19	emerges	emerge	VBZ
cord-260054-iihgc5nr	130	20	that	that	IN
cord-260054-iihgc5nr	130	21	the	the	DT
cord-260054-iihgc5nr	130	22	S929I	S929I	NNP
cord-260054-iihgc5nr	130	23	,	,	,
cord-260054-iihgc5nr	130	24	D936Y	D936Y	NNP
cord-260054-iihgc5nr	130	25	and	and	CC
cord-260054-iihgc5nr	130	26	S943I	s943i	NN
cord-260054-iihgc5nr	130	27	mutations	mutation	NNS
cord-260054-iihgc5nr	130	28	strongly	strongly	RB
cord-260054-iihgc5nr	130	29	destabilize	destabilize	VBP
cord-260054-iihgc5nr	130	30	the	the	DT
cord-260054-iihgc5nr	130	31	postfusion	postfusion	NN
cord-260054-iihgc5nr	130	32	conformation	conformation	NN
cord-260054-iihgc5nr	130	33	,	,	,
cord-260054-iihgc5nr	130	34	while	while	IN
cord-260054-iihgc5nr	130	35	having	have	VBG
cord-260054-iihgc5nr	130	36	a	a	DT
cord-260054-iihgc5nr	130	37	marginal	marginal	JJ
cord-260054-iihgc5nr	130	38	impact	impact	NN
cord-260054-iihgc5nr	130	39	on	on	IN
cord-260054-iihgc5nr	130	40	the	the	DT
cord-260054-iihgc5nr	130	41	stability	stability	NN
cord-260054-iihgc5nr	130	42	of	of	IN
cord-260054-iihgc5nr	130	43	the	the	DT
cord-260054-iihgc5nr	130	44	pre	pre	JJ
cord-260054-iihgc5nr	130	45	-	-	JJ
cord-260054-iihgc5nr	130	46	fusion	fusion	JJ
cord-260054-iihgc5nr	130	47	one	one	CD
cord-260054-iihgc5nr	130	48	.	.	.
cord-260054-iihgc5nr	131	1	On	on	IN
cord-260054-iihgc5nr	131	2	the	the	DT
cord-260054-iihgc5nr	131	3	contrary	contrary	NN
cord-260054-iihgc5nr	131	4	,	,	,
cord-260054-iihgc5nr	131	5	S940F	S940F	NNP
cord-260054-iihgc5nr	131	6	seems	seem	VBZ
cord-260054-iihgc5nr	131	7	to	to	TO
cord-260054-iihgc5nr	131	8	favour	favour	VB
cord-260054-iihgc5nr	131	9	the	the	DT
cord-260054-iihgc5nr	131	10	post	post	JJ
cord-260054-iihgc5nr	131	11	-	-	JJ
cord-260054-iihgc5nr	131	12	fusion	fusion	JJ
cord-260054-iihgc5nr	131	13	conformation	conformation	NN
cord-260054-iihgc5nr	131	14	over	over	IN
cord-260054-iihgc5nr	131	15	the	the	DT
cord-260054-iihgc5nr	131	16	pre	pre	JJ
cord-260054-iihgc5nr	131	17	-	-	JJ
cord-260054-iihgc5nr	131	18	fusion	fusion	JJ
cord-260054-iihgc5nr	131	19	one	one	CD
cord-260054-iihgc5nr	131	20	.	.	.
cord-260054-iihgc5nr	132	1	As	as	IN
cord-260054-iihgc5nr	132	2	for	for	IN
cord-260054-iihgc5nr	132	3	S938F	S938F	NNP
cord-260054-iihgc5nr	132	4	and	and	CC
cord-260054-iihgc5nr	132	5	S939F	S939F	NNP
cord-260054-iihgc5nr	132	6	,	,	,
cord-260054-iihgc5nr	132	7	they	-PRON-	PRP
cord-260054-iihgc5nr	132	8	seem	seem	VBP
cord-260054-iihgc5nr	132	9	to	to	TO
cord-260054-iihgc5nr	132	10	have	have	VB
cord-260054-iihgc5nr	132	11	a	a	DT
cord-260054-iihgc5nr	132	12	comparable	comparable	JJ
cord-260054-iihgc5nr	132	13	effect	effect	NN
cord-260054-iihgc5nr	132	14	on	on	IN
cord-260054-iihgc5nr	132	15	both	both	CC
cord-260054-iihgc5nr	132	16	the	the	DT
cord-260054-iihgc5nr	132	17	conformations	conformation	NNS
cord-260054-iihgc5nr	132	18	,	,	,
cord-260054-iihgc5nr	132	19	slightly	slightly	RB
cord-260054-iihgc5nr	132	20	stabilizing	stabilize	VBG
cord-260054-iihgc5nr	132	21	and	and	CC
cord-260054-iihgc5nr	132	22	destabilizing	destabilizing	JJ
cord-260054-iihgc5nr	132	23	,	,	,
cord-260054-iihgc5nr	132	24	respectively	respectively	RB
cord-260054-iihgc5nr	132	25	.	.	.
cord-260054-iihgc5nr	133	1	Finally	finally	RB
cord-260054-iihgc5nr	133	2	,	,	,
cord-260054-iihgc5nr	133	3	the	the	DT
cord-260054-iihgc5nr	133	4	S943P	s943p	NN
cord-260054-iihgc5nr	133	5	mutation	mutation	NN
cord-260054-iihgc5nr	133	6	would	would	MD
cord-260054-iihgc5nr	133	7	strongly	strongly	RB
cord-260054-iihgc5nr	133	8	destabilize	destabilize	VB
cord-260054-iihgc5nr	133	9	both	both	CC
cord-260054-iihgc5nr	133	10	the	the	DT
cord-260054-iihgc5nr	133	11	pre	pre	NN
cord-260054-iihgc5nr	133	12	-	-	JJ
cord-260054-iihgc5nr	133	13	and	and	CC
cord-260054-iihgc5nr	133	14	post	post	JJ
cord-260054-iihgc5nr	133	15	-	-	JJ
cord-260054-iihgc5nr	133	16	fusion	fusion	JJ
cord-260054-iihgc5nr	133	17	conformations	conformation	NNS
cord-260054-iihgc5nr	133	18	.	.	.
cord-260054-iihgc5nr	134	1	Based	base	VBN
cord-260054-iihgc5nr	134	2	on	on	IN
cord-260054-iihgc5nr	134	3	a	a	DT
cord-260054-iihgc5nr	134	4	thorough	thorough	JJ
cord-260054-iihgc5nr	134	5	analysis	analysis	NN
cord-260054-iihgc5nr	134	6	of	of	IN
cord-260054-iihgc5nr	134	7	the	the	DT
cord-260054-iihgc5nr	134	8	S	S	NNP
cord-260054-iihgc5nr	134	9	protein	protein	NN
cord-260054-iihgc5nr	134	10	sequences	sequence	NNS
cord-260054-iihgc5nr	134	11	,	,	,
cord-260054-iihgc5nr	134	12	that	that	IN
cord-260054-iihgc5nr	134	13	we	-PRON-	PRP
cord-260054-iihgc5nr	134	14	extracted	extract	VBD
cord-260054-iihgc5nr	134	15	from	from	IN
cord-260054-iihgc5nr	134	16	the	the	DT
cord-260054-iihgc5nr	134	17	genomic	genomic	JJ
cord-260054-iihgc5nr	134	18	sequences	sequence	NNS
cord-260054-iihgc5nr	134	19	of	of	IN
cord-260054-iihgc5nr	134	20	SARS	SARS	NNP
cord-260054-iihgc5nr	134	21	-	-	HYPH
cord-260054-iihgc5nr	134	22	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	134	23	reported	report	VBD
cord-260054-iihgc5nr	134	24	in	in	IN
cord-260054-iihgc5nr	134	25	GISAID	GISAID	NNP
cord-260054-iihgc5nr	134	26	on	on	IN
cord-260054-iihgc5nr	134	27	April	April	NNP
cord-260054-iihgc5nr	134	28	21	21	CD
cord-260054-iihgc5nr	134	29	st	st	NNP
cord-260054-iihgc5nr	134	30	,	,	,
cord-260054-iihgc5nr	134	31	we	-PRON-	PRP
cord-260054-iihgc5nr	134	32	identified	identify	VBD
cord-260054-iihgc5nr	134	33	the	the	DT
cord-260054-iihgc5nr	134	34	fusion	fusion	NN
cord-260054-iihgc5nr	134	35	core	core	NN
cord-260054-iihgc5nr	134	36	of	of	IN
cord-260054-iihgc5nr	134	37	the	the	DT
cord-260054-iihgc5nr	134	38	HR1	HR1	NNP
cord-260054-iihgc5nr	134	39	as	as	IN
cord-260054-iihgc5nr	134	40	a	a	DT
cord-260054-iihgc5nr	134	41	mutational	mutational	JJ
cord-260054-iihgc5nr	134	42	hotspot	hotspot	NN
cord-260054-iihgc5nr	134	43	.	.	.
cord-260054-iihgc5nr	135	1	The	the	DT
cord-260054-iihgc5nr	135	2	D936Y	D936Y	NNP
cord-260054-iihgc5nr	135	3	and	and	CC
cord-260054-iihgc5nr	135	4	S943P	s943p	NN
cord-260054-iihgc5nr	135	5	mutations	mutation	NNS
cord-260054-iihgc5nr	135	6	were	be	VBD
cord-260054-iihgc5nr	135	7	the	the	DT
cord-260054-iihgc5nr	135	8	most	most	RBS
cord-260054-iihgc5nr	135	9	numerous	numerous	JJ
cord-260054-iihgc5nr	135	10	,	,	,
cord-260054-iihgc5nr	135	11	being	be	VBG
cord-260054-iihgc5nr	135	12	among	among	IN
cord-260054-iihgc5nr	135	13	the	the	DT
cord-260054-iihgc5nr	135	14	most	most	RBS
cord-260054-iihgc5nr	135	15	frequently	frequently	RB
cord-260054-iihgc5nr	135	16	occurring	occur	VBG
cord-260054-iihgc5nr	135	17	mutations	mutation	NNS
cord-260054-iihgc5nr	135	18	overall	overall	RB
cord-260054-iihgc5nr	135	19	at	at	IN
cord-260054-iihgc5nr	135	20	the	the	DT
cord-260054-iihgc5nr	135	21	time	time	NN
cord-260054-iihgc5nr	135	22	.	.	.
cord-260054-iihgc5nr	136	1	Other	other	JJ
cord-260054-iihgc5nr	136	2	,	,	,
cord-260054-iihgc5nr	136	3	less	less	RBR
cord-260054-iihgc5nr	136	4	frequent	frequent	JJ
cord-260054-iihgc5nr	136	5	,	,	,
cord-260054-iihgc5nr	136	6	mutations	mutation	NNS
cord-260054-iihgc5nr	136	7	were	be	VBD
cord-260054-iihgc5nr	136	8	S939F	S939F	NNP
cord-260054-iihgc5nr	136	9	and	and	CC
cord-260054-iihgc5nr	136	10	then	then	RB
cord-260054-iihgc5nr	136	11	S929I	S929I	NNP
cord-260054-iihgc5nr	136	12	,	,	,
cord-260054-iihgc5nr	136	13	L938F	L938F	NNP
cord-260054-iihgc5nr	136	14	and	and	CC
cord-260054-iihgc5nr	136	15	S940F.	s940f.	NN
cord-260054-iihgc5nr	137	1	Overall	overall	RB
cord-260054-iihgc5nr	137	2	,	,	,
cord-260054-iihgc5nr	137	3	such	such	JJ
cord-260054-iihgc5nr	137	4	mutations	mutation	NNS
cord-260054-iihgc5nr	137	5	appeared	appear	VBD
cord-260054-iihgc5nr	137	6	to	to	TO
cord-260054-iihgc5nr	137	7	be	be	VB
cord-260054-iihgc5nr	137	8	late	late	JJ
cord-260054-iihgc5nr	137	9	ones	one	NNS
cord-260054-iihgc5nr	137	10	,	,	,
cord-260054-iihgc5nr	137	11	emerging	emerge	VBG
cord-260054-iihgc5nr	137	12	starting	start	VBG
cord-260054-iihgc5nr	137	13	from	from	IN
cord-260054-iihgc5nr	137	14	the	the	DT
cord-260054-iihgc5nr	137	15	end	end	NN
cord-260054-iihgc5nr	137	16	of	of	IN
cord-260054-iihgc5nr	137	17	February	February	NNP
cord-260054-iihgc5nr	137	18	or	or	CC
cord-260054-iihgc5nr	137	19	even	even	RB
cord-260054-iihgc5nr	137	20	mid	mid	JJ
cord-260054-iihgc5nr	137	21	March	March	NNP
cord-260054-iihgc5nr	137	22	2020	2020	CD
cord-260054-iihgc5nr	137	23	,	,	,
cord-260054-iihgc5nr	137	24	and	and	CC
cord-260054-iihgc5nr	137	25	were	be	VBD
cord-260054-iihgc5nr	137	26	mainly	mainly	RB
cord-260054-iihgc5nr	137	27	localized	localize	VBN
cord-260054-iihgc5nr	137	28	in	in	IN
cord-260054-iihgc5nr	137	29	Europe	Europe	NNP
cord-260054-iihgc5nr	137	30	and	and	CC
cord-260054-iihgc5nr	137	31	USA	USA	NNP
cord-260054-iihgc5nr	137	32	.	.	.
cord-260054-iihgc5nr	138	1	Based	base	VBN
cord-260054-iihgc5nr	138	2	on	on	IN
cord-260054-iihgc5nr	138	3	their	-PRON-	PRP$
cord-260054-iihgc5nr	138	4	frequency	frequency	NN
cord-260054-iihgc5nr	138	5	,	,	,
cord-260054-iihgc5nr	138	6	on	on	IN
cord-260054-iihgc5nr	138	7	their	-PRON-	PRP$
cord-260054-iihgc5nr	138	8	location	location	NN
cord-260054-iihgc5nr	138	9	in	in	IN
cord-260054-iihgc5nr	138	10	a	a	DT
cord-260054-iihgc5nr	138	11	protein	protein	NN
cord-260054-iihgc5nr	138	12	region	region	NN
cord-260054-iihgc5nr	138	13	playing	play	VBG
cord-260054-iihgc5nr	138	14	a	a	DT
cord-260054-iihgc5nr	138	15	key	key	JJ
cord-260054-iihgc5nr	138	16	role	role	NN
cord-260054-iihgc5nr	138	17	in	in	IN
cord-260054-iihgc5nr	138	18	the	the	DT
cord-260054-iihgc5nr	138	19	post	post	JJ
cord-260054-iihgc5nr	138	20	-	-	JJ
cord-260054-iihgc5nr	138	21	fusion	fusion	JJ
cord-260054-iihgc5nr	138	22	conformation	conformation	NN
cord-260054-iihgc5nr	138	23	and	and	CC
cord-260054-iihgc5nr	138	24	also	also	RB
cord-260054-iihgc5nr	138	25	on	on	IN
cord-260054-iihgc5nr	138	26	the	the	DT
cord-260054-iihgc5nr	138	27	non	non	JJ
cord-260054-iihgc5nr	138	28	-	-	JJ
cord-260054-iihgc5nr	138	29	conservative	conservative	JJ
cord-260054-iihgc5nr	138	30	nature	nature	NN
cord-260054-iihgc5nr	138	31	of	of	IN
cord-260054-iihgc5nr	138	32	the	the	DT
cord-260054-iihgc5nr	138	33	mutations	mutation	NNS
cord-260054-iihgc5nr	138	34	themselves	-PRON-	PRP
cord-260054-iihgc5nr	138	35	,	,	,
cord-260054-iihgc5nr	138	36	we	-PRON-	PRP
cord-260054-iihgc5nr	138	37	decided	decide	VBD
cord-260054-iihgc5nr	138	38	to	to	TO
cord-260054-iihgc5nr	138	39	further	further	RB
cord-260054-iihgc5nr	138	40	investigate	investigate	VB
cord-260054-iihgc5nr	138	41	the	the	DT
cord-260054-iihgc5nr	138	42	structural	structural	JJ
cord-260054-iihgc5nr	138	43	basis	basis	NN
cord-260054-iihgc5nr	138	44	of	of	IN
cord-260054-iihgc5nr	138	45	such	such	JJ
cord-260054-iihgc5nr	138	46	mutations	mutation	NNS
cord-260054-iihgc5nr	138	47	,	,	,
cord-260054-iihgc5nr	138	48	finding	find	VBG
cord-260054-iihgc5nr	138	49	out	out	RP
cord-260054-iihgc5nr	138	50	that	that	IN
cord-260054-iihgc5nr	138	51	they	-PRON-	PRP
cord-260054-iihgc5nr	138	52	all	all	DT
cord-260054-iihgc5nr	138	53	can	can	MD
cord-260054-iihgc5nr	138	54	play	play	VB
cord-260054-iihgc5nr	138	55	a	a	DT
cord-260054-iihgc5nr	138	56	role	role	NN
cord-260054-iihgc5nr	138	57	in	in	IN
cord-260054-iihgc5nr	138	58	tuning	tune	VBG
cord-260054-iihgc5nr	138	59	the	the	DT
cord-260054-iihgc5nr	138	60	stability	stability	NN
cord-260054-iihgc5nr	138	61	of	of	IN
cord-260054-iihgc5nr	138	62	the	the	DT
cord-260054-iihgc5nr	138	63	preand	preand	NN
cord-260054-iihgc5nr	138	64	/	/	SYM
cord-260054-iihgc5nr	138	65	or	or	CC
cord-260054-iihgc5nr	138	66	post	post	JJ
cord-260054-iihgc5nr	138	67	-	-	JJ
cord-260054-iihgc5nr	138	68	fusion	fusion	JJ
cord-260054-iihgc5nr	138	69	S	S	NNP
cord-260054-iihgc5nr	138	70	protein	protein	NN
cord-260054-iihgc5nr	138	71	conformation	conformation	NN
cord-260054-iihgc5nr	138	72	.	.	.
cord-260054-iihgc5nr	139	1	Other	other	JJ
cord-260054-iihgc5nr	139	2	potentially	potentially	RB
cord-260054-iihgc5nr	139	3	interesting	interesting	JJ
cord-260054-iihgc5nr	139	4	mutations	mutation	NNS
cord-260054-iihgc5nr	139	5	are	be	VBP
cord-260054-iihgc5nr	139	6	S929I	S929I	NNP
cord-260054-iihgc5nr	139	7	and	and	CC
cord-260054-iihgc5nr	139	8	S939F	S939F	NNP
cord-260054-iihgc5nr	139	9	,	,	,
cord-260054-iihgc5nr	139	10	whose	whose	WP$
cord-260054-iihgc5nr	139	11	number	number	NN
cord-260054-iihgc5nr	139	12	of	of	IN
cord-260054-iihgc5nr	139	13	occurrences	occurrence	NNS
cord-260054-iihgc5nr	139	14	underwent	undergo	VBD
cord-260054-iihgc5nr	139	15	a	a	DT
cord-260054-iihgc5nr	139	16	≈2/3-fold	≈2/3-fold	NNP
cord-260054-iihgc5nr	139	17	increase	increase	NN
cord-260054-iihgc5nr	139	18	.	.	.
cord-260054-iihgc5nr	140	1	On	on	IN
cord-260054-iihgc5nr	140	2	the	the	DT
cord-260054-iihgc5nr	140	3	other	other	JJ
cord-260054-iihgc5nr	140	4	hand	hand	NN
cord-260054-iihgc5nr	140	5	,	,	,
cord-260054-iihgc5nr	140	6	the	the	DT
cord-260054-iihgc5nr	140	7	increment	increment	NN
cord-260054-iihgc5nr	140	8	in	in	IN
cord-260054-iihgc5nr	140	9	the	the	DT
cord-260054-iihgc5nr	140	10	occurrence	occurrence	NN
cord-260054-iihgc5nr	140	11	of	of	IN
cord-260054-iihgc5nr	140	12	L938F	L938F	NNP
cord-260054-iihgc5nr	140	13	and	and	CC
cord-260054-iihgc5nr	140	14	S940F	S940F	NNP
cord-260054-iihgc5nr	140	15	was	be	VBD
cord-260054-iihgc5nr	140	16	marginal	marginal	JJ
cord-260054-iihgc5nr	140	17	,	,	,
cord-260054-iihgc5nr	140	18	posing	pose	VBG
cord-260054-iihgc5nr	140	19	less	less	JJR
cord-260054-iihgc5nr	140	20	emphasis	emphasis	NN
cord-260054-iihgc5nr	140	21	on	on	IN
cord-260054-iihgc5nr	140	22	such	such	JJ
cord-260054-iihgc5nr	140	23	mutations	mutation	NNS
cord-260054-iihgc5nr	140	24	,	,	,
cord-260054-iihgc5nr	140	25	which	which	WDT
cord-260054-iihgc5nr	140	26	will	will	MD
cord-260054-iihgc5nr	140	27	be	be	VB
cord-260054-iihgc5nr	140	28	nonetheless	nonetheless	RB
cord-260054-iihgc5nr	140	29	useful	useful	JJ
cord-260054-iihgc5nr	140	30	to	to	TO
cord-260054-iihgc5nr	140	31	continue	continue	VB
cord-260054-iihgc5nr	140	32	monitoring	monitor	VBG
cord-260054-iihgc5nr	140	33	.	.	.
cord-260054-iihgc5nr	141	1	Finally	finally	RB
cord-260054-iihgc5nr	141	2	,	,	,
cord-260054-iihgc5nr	141	3	the	the	DT
cord-260054-iihgc5nr	141	4	S943P	S943P	NNP
cord-260054-iihgc5nr	141	5	mutation	mutation	NN
cord-260054-iihgc5nr	141	6	,	,	,
cord-260054-iihgc5nr	141	7	although	although	IN
cord-260054-iihgc5nr	141	8	still	still	RB
cord-260054-iihgc5nr	141	9	reported	report	VBN
cord-260054-iihgc5nr	141	10	in	in	IN
cord-260054-iihgc5nr	141	11	few	few	JJ
cord-260054-iihgc5nr	141	12	cases	case	NNS
cord-260054-iihgc5nr	141	13	,	,	,
cord-260054-iihgc5nr	141	14	underwent	undergo	VBD
cord-260054-iihgc5nr	141	15	a	a	DT
cord-260054-iihgc5nr	141	16	dramatic	dramatic	JJ
cord-260054-iihgc5nr	141	17	reduction	reduction	NN
cord-260054-iihgc5nr	141	18	of	of	IN
cord-260054-iihgc5nr	141	19	occurrences	occurrence	NNS
cord-260054-iihgc5nr	141	20	,	,	,
cord-260054-iihgc5nr	141	21	due	due	IN
cord-260054-iihgc5nr	141	22	to	to	IN
cord-260054-iihgc5nr	141	23	modification	modification	NN
cord-260054-iihgc5nr	141	24	of	of	IN
cord-260054-iihgc5nr	141	25	the	the	DT
cord-260054-iihgc5nr	141	26	original	original	JJ
cord-260054-iihgc5nr	141	27	sequences	sequence	NNS
cord-260054-iihgc5nr	141	28	where	where	WRB
cord-260054-iihgc5nr	141	29	they	-PRON-	PRP
cord-260054-iihgc5nr	141	30	were	be	VBD
cord-260054-iihgc5nr	141	31	first	first	RB
cord-260054-iihgc5nr	141	32	reported	report	VBN
cord-260054-iihgc5nr	141	33	.	.	.
cord-260054-iihgc5nr	142	1	At	at	IN
cord-260054-iihgc5nr	142	2	the	the	DT
cord-260054-iihgc5nr	142	3	same	same	JJ
cord-260054-iihgc5nr	142	4	time	time	NN
cord-260054-iihgc5nr	142	5	,	,	,
cord-260054-iihgc5nr	142	6	a	a	DT
cord-260054-iihgc5nr	142	7	S943I	S943I	NNP
cord-260054-iihgc5nr	142	8	mutation	mutation	NN
cord-260054-iihgc5nr	142	9	emerged	emerge	VBD
cord-260054-iihgc5nr	142	10	,	,	,
cord-260054-iihgc5nr	142	11	that	that	DT
cord-260054-iihgc5nr	142	12	will	will	MD
cord-260054-iihgc5nr	142	13	also	also	RB
cord-260054-iihgc5nr	142	14	be	be	VB
cord-260054-iihgc5nr	142	15	worth	worth	JJ
cord-260054-iihgc5nr	142	16	continuing	continue	VBG
cord-260054-iihgc5nr	142	17	to	to	TO
cord-260054-iihgc5nr	142	18	monitor	monitor	VB
cord-260054-iihgc5nr	142	19	.	.	.
cord-260054-iihgc5nr	143	1	We	-PRON-	PRP
cord-260054-iihgc5nr	143	2	remind	remind	VBP
cord-260054-iihgc5nr	143	3	here	here	RB
cord-260054-iihgc5nr	143	4	that	that	IN
cord-260054-iihgc5nr	143	5	a	a	DT
cord-260054-iihgc5nr	143	6	proline	proline	NN
cord-260054-iihgc5nr	143	7	at	at	IN
cord-260054-iihgc5nr	143	8	position	position	NN
cord-260054-iihgc5nr	143	9	943	943	CD
cord-260054-iihgc5nr	143	10	would	would	MD
cord-260054-iihgc5nr	143	11	cause	cause	VB
cord-260054-iihgc5nr	143	12	a	a	DT
cord-260054-iihgc5nr	143	13	significant	significant	JJ
cord-260054-iihgc5nr	143	14	destabilization	destabilization	NN
cord-260054-iihgc5nr	143	15	on	on	IN
cord-260054-iihgc5nr	143	16	the	the	DT
cord-260054-iihgc5nr	143	17	S	S	NNP
cord-260054-iihgc5nr	143	18	protein	protein	NN
cord-260054-iihgc5nr	143	19	pre	pre	JJ
cord-260054-iihgc5nr	143	20	-	-	JJ
cord-260054-iihgc5nr	143	21	fusion	fusion	JJ
cord-260054-iihgc5nr	143	22	conformation	conformation	NN
cord-260054-iihgc5nr	143	23	.	.	.
cord-260054-iihgc5nr	144	1	It	-PRON-	PRP
cord-260054-iihgc5nr	144	2	is	be	VBZ
cord-260054-iihgc5nr	144	3	also	also	RB
cord-260054-iihgc5nr	144	4	worth	worth	JJ
cord-260054-iihgc5nr	144	5	noticing	notice	VBG
cord-260054-iihgc5nr	144	6	that	that	IN
cord-260054-iihgc5nr	144	7	the	the	DT
cord-260054-iihgc5nr	144	8	2	2	CD
cord-260054-iihgc5nr	144	9	mutations	mutation	NNS
cord-260054-iihgc5nr	144	10	significantly	significantly	RB
cord-260054-iihgc5nr	144	11	increasing	increase	VBG
cord-260054-iihgc5nr	144	12	their	-PRON-	PRP$
cord-260054-iihgc5nr	144	13	frequency	frequency	NN
cord-260054-iihgc5nr	144	14	over	over	IN
cord-260054-iihgc5nr	144	15	time	time	NN
cord-260054-iihgc5nr	144	16	,	,	,
cord-260054-iihgc5nr	144	17	D936Y	D936Y	NNP
cord-260054-iihgc5nr	144	18	and	and	CC
cord-260054-iihgc5nr	144	19	S929I	S929I	NNP
cord-260054-iihgc5nr	144	20	,	,	,
cord-260054-iihgc5nr	144	21	were	be	VBD
cord-260054-iihgc5nr	144	22	also	also	RB
cord-260054-iihgc5nr	144	23	those	those	DT
cord-260054-iihgc5nr	144	24	that	that	WDT
cord-260054-iihgc5nr	144	25	,	,	,
cord-260054-iihgc5nr	144	26	together	together	RB
cord-260054-iihgc5nr	144	27	with	with	IN
cord-260054-iihgc5nr	144	28	S943P	s943p	NN
cord-260054-iihgc5nr	144	29	/	/	SYM
cord-260054-iihgc5nr	144	30	I	-PRON-	PRP
cord-260054-iihgc5nr	144	31	,	,	,
cord-260054-iihgc5nr	144	32	caused	cause	VBD
cord-260054-iihgc5nr	144	33	the	the	DT
cord-260054-iihgc5nr	144	34	loss	loss	NN
cord-260054-iihgc5nr	144	35	of	of	IN
cord-260054-iihgc5nr	144	36	a	a	DT
cord-260054-iihgc5nr	144	37	inter	inter	JJ
cord-260054-iihgc5nr	144	38	-	-	JJ
cord-260054-iihgc5nr	144	39	monomer	monomer	JJ
cord-260054-iihgc5nr	144	40	H	h	NN
cord-260054-iihgc5nr	144	41	-	-	HYPH
cord-260054-iihgc5nr	144	42	bond	bond	NN
cord-260054-iihgc5nr	144	43	in	in	IN
cord-260054-iihgc5nr	144	44	the	the	DT
cord-260054-iihgc5nr	144	45	post	post	JJ
cord-260054-iihgc5nr	144	46	-	-	JJ
cord-260054-iihgc5nr	144	47	fusion	fusion	JJ
cord-260054-iihgc5nr	144	48	conformation	conformation	NN
cord-260054-iihgc5nr	144	49	of	of	IN
cord-260054-iihgc5nr	144	50	the	the	DT
cord-260054-iihgc5nr	144	51	protein	protein	NN
cord-260054-iihgc5nr	144	52	.	.	.
cord-260054-iihgc5nr	145	1	Interestingly	interestingly	RB
cord-260054-iihgc5nr	145	2	,	,	,
cord-260054-iihgc5nr	145	3	the	the	DT
cord-260054-iihgc5nr	145	4	now	now	RB
cord-260054-iihgc5nr	145	5	emerging	emerge	VBG
cord-260054-iihgc5nr	145	6	S943I	S943I	NNP
cord-260054-iihgc5nr	145	7	mutation	mutation	NN
cord-260054-iihgc5nr	145	8	gets	get	VBZ
cord-260054-iihgc5nr	145	9	the	the	DT
cord-260054-iihgc5nr	145	10	same	same	JJ
cord-260054-iihgc5nr	145	11	effect	effect	NN
cord-260054-iihgc5nr	145	12	without	without	IN
cord-260054-iihgc5nr	145	13	destabilizing	destabilize	VBG
cord-260054-iihgc5nr	145	14	the	the	DT
cord-260054-iihgc5nr	145	15	pre	pre	JJ
cord-260054-iihgc5nr	145	16	-	-	JJ
cord-260054-iihgc5nr	145	17	fusion	fusion	JJ
cord-260054-iihgc5nr	145	18	conformation	conformation	NN
cord-260054-iihgc5nr	145	19	.	.	.
cord-260054-iihgc5nr	146	1	The	the	DT
cord-260054-iihgc5nr	146	2	most	most	RBS
cord-260054-iihgc5nr	146	3	frequently	frequently	RB
cord-260054-iihgc5nr	146	4	occurring	occur	VBG
cord-260054-iihgc5nr	146	5	mutation	mutation	NN
cord-260054-iihgc5nr	146	6	in	in	IN
cord-260054-iihgc5nr	146	7	the	the	DT
cord-260054-iihgc5nr	146	8	HR1	HR1	NNP
cord-260054-iihgc5nr	146	9	"	"	``
cord-260054-iihgc5nr	146	10	fusion	fusion	NN
cord-260054-iihgc5nr	146	11	core	core	NN
cord-260054-iihgc5nr	146	12	"	"	''
cord-260054-iihgc5nr	146	13	,	,	,
cord-260054-iihgc5nr	146	14	common	common	JJ
cord-260054-iihgc5nr	146	15	in	in	IN
cord-260054-iihgc5nr	146	16	Sweden	Sweden	NNP
cord-260054-iihgc5nr	146	17	and	and	CC
cord-260054-iihgc5nr	146	18	UK	UK	NNP
cord-260054-iihgc5nr	146	19	on	on	IN
cord-260054-iihgc5nr	146	20	May	May	NNP
cord-260054-iihgc5nr	146	21	29	29	CD
cord-260054-iihgc5nr	146	22	th	th	XX
cord-260054-iihgc5nr	146	23	,	,	,
cord-260054-iihgc5nr	146	24	is	be	VBZ
cord-260054-iihgc5nr	146	25	also	also	RB
cord-260054-iihgc5nr	146	26	the	the	DT
cord-260054-iihgc5nr	146	27	one	one	NN
cord-260054-iihgc5nr	146	28	causing	cause	VBG
cord-260054-iihgc5nr	146	29	the	the	DT
cord-260054-iihgc5nr	146	30	loss	loss	NN
cord-260054-iihgc5nr	146	31	of	of	IN
cord-260054-iihgc5nr	146	32	a	a	DT
cord-260054-iihgc5nr	146	33	strong	strong	JJ
cord-260054-iihgc5nr	146	34	inter	inter	JJ
cord-260054-iihgc5nr	146	35	-	-	JJ
cord-260054-iihgc5nr	146	36	monomer	monomer	JJ
cord-260054-iihgc5nr	146	37	salt	salt	NN
cord-260054-iihgc5nr	146	38	bridge	bridge	NN
cord-260054-iihgc5nr	146	39	.	.	.
cord-260054-iihgc5nr	147	1	Our	-PRON-	PRP$
cord-260054-iihgc5nr	147	2	structural	structural	JJ
cord-260054-iihgc5nr	147	3	analyses	analysis	NNS
cord-260054-iihgc5nr	147	4	provide	provide	VBP
cord-260054-iihgc5nr	147	5	a	a	DT
cord-260054-iihgc5nr	147	6	rationale	rationale	NN
cord-260054-iihgc5nr	147	7	for	for	IN
cord-260054-iihgc5nr	147	8	such	such	JJ
cord-260054-iihgc5nr	147	9	mutations	mutation	NNS
cord-260054-iihgc5nr	147	10	,	,	,
cord-260054-iihgc5nr	147	11	pointing	point	VBG
cord-260054-iihgc5nr	147	12	to	to	IN
cord-260054-iihgc5nr	147	13	a	a	DT
cord-260054-iihgc5nr	147	14	weakening	weakening	NN
cord-260054-iihgc5nr	147	15	of	of	IN
cord-260054-iihgc5nr	147	16	the	the	DT
cord-260054-iihgc5nr	147	17	post	post	JJ
cord-260054-iihgc5nr	147	18	-	-	JJ
cord-260054-iihgc5nr	147	19	fusion	fusion	JJ
cord-260054-iihgc5nr	147	20	assembly	assembly	NN
cord-260054-iihgc5nr	147	21	.	.	.
cord-260054-iihgc5nr	148	1	However	however	RB
cord-260054-iihgc5nr	148	2	,	,	,
cord-260054-iihgc5nr	148	3	only	only	RB
cord-260054-iihgc5nr	148	4	experiments	experiment	NNS
cord-260054-iihgc5nr	148	5	on	on	IN
cord-260054-iihgc5nr	148	6	cellular	cellular	JJ
cord-260054-iihgc5nr	148	7	systems	system	NNS
cord-260054-iihgc5nr	148	8	will	will	MD
cord-260054-iihgc5nr	148	9	clarify	clarify	VB
cord-260054-iihgc5nr	148	10	whether	whether	IN
cord-260054-iihgc5nr	148	11	this	this	DT
cord-260054-iihgc5nr	148	12	may	may	MD
cord-260054-iihgc5nr	148	13	be	be	VB
cord-260054-iihgc5nr	148	14	a	a	DT
cord-260054-iihgc5nr	148	15	virus	virus	NN
cord-260054-iihgc5nr	148	16	strategy	strategy	NN
cord-260054-iihgc5nr	148	17	for	for	IN
cord-260054-iihgc5nr	148	18	reducing	reduce	VBG
cord-260054-iihgc5nr	148	19	its	-PRON-	PRP$
cord-260054-iihgc5nr	148	20	membrane	membrane	NN
cord-260054-iihgc5nr	148	21	fusion	fusion	NN
cord-260054-iihgc5nr	148	22	capacity	capacity	NN
cord-260054-iihgc5nr	148	23	,	,	,
cord-260054-iihgc5nr	148	24	thus	thus	RB
cord-260054-iihgc5nr	148	25	lowering	lower	VBG
cord-260054-iihgc5nr	148	26	its	-PRON-	PRP$
cord-260054-iihgc5nr	148	27	virulence	virulence	NN
cord-260054-iihgc5nr	148	28	.	.	.
cord-260054-iihgc5nr	149	1	We	-PRON-	PRP
cord-260054-iihgc5nr	149	2	gratefully	gratefully	RB
cord-260054-iihgc5nr	149	3	acknowledge	acknowledge	VBP
cord-260054-iihgc5nr	149	4	all	all	PDT
cord-260054-iihgc5nr	149	5	the	the	DT
cord-260054-iihgc5nr	149	6	Authors	author	NNS
cord-260054-iihgc5nr	149	7	from	from	IN
cord-260054-iihgc5nr	149	8	the	the	DT
cord-260054-iihgc5nr	149	9	Originating	originate	VBG
cord-260054-iihgc5nr	149	10	laboratories	laboratory	NNS
cord-260054-iihgc5nr	149	11	responsible	responsible	JJ
cord-260054-iihgc5nr	149	12	for	for	IN
cord-260054-iihgc5nr	149	13	obtaining	obtain	VBG
cord-260054-iihgc5nr	149	14	the	the	DT
cord-260054-iihgc5nr	149	15	specimens	specimen	NNS
cord-260054-iihgc5nr	149	16	and	and	CC
cord-260054-iihgc5nr	149	17	the	the	DT
cord-260054-iihgc5nr	149	18	Submitting	submit	VBG
cord-260054-iihgc5nr	149	19	laboratories	laboratory	NNS
cord-260054-iihgc5nr	149	20	where	where	WRB
cord-260054-iihgc5nr	149	21	genetic	genetic	JJ
cord-260054-iihgc5nr	149	22	sequence	sequence	NN
cord-260054-iihgc5nr	149	23	data	datum	NNS
cord-260054-iihgc5nr	149	24	were	be	VBD
cord-260054-iihgc5nr	149	25	generated	generate	VBN
cord-260054-iihgc5nr	149	26	and	and	CC
cord-260054-iihgc5nr	149	27	shared	share	VBN
cord-260054-iihgc5nr	149	28	via	via	IN
cord-260054-iihgc5nr	149	29	the	the	DT
cord-260054-iihgc5nr	149	30	GISAID	GISAID	NNP
cord-260054-iihgc5nr	149	31	Initiative	Initiative	NNP
cord-260054-iihgc5nr	149	32	,	,	,
cord-260054-iihgc5nr	149	33	on	on	IN
cord-260054-iihgc5nr	149	34	which	which	WDT
cord-260054-iihgc5nr	149	35	this	this	DT
cord-260054-iihgc5nr	149	36	research	research	NN
cord-260054-iihgc5nr	149	37	is	be	VBZ
cord-260054-iihgc5nr	149	38	based	base	VBN
cord-260054-iihgc5nr	149	39	.	.	.
cord-260054-iihgc5nr	150	1	Table	table	NN
cord-260054-iihgc5nr	150	2	2	2	CD
cord-260054-iihgc5nr	150	3	.	.	.
cord-260054-iihgc5nr	151	1	Solvent	solvent	NN
cord-260054-iihgc5nr	151	2	accessibility	accessibility	NN
cord-260054-iihgc5nr	151	3	of	of	IN
cord-260054-iihgc5nr	151	4	mutated	mutated	JJ
cord-260054-iihgc5nr	151	5	residues	residue	NNS
cord-260054-iihgc5nr	151	6	in	in	IN
cord-260054-iihgc5nr	151	7	the	the	DT
cord-260054-iihgc5nr	151	8	pre	pre	NN
cord-260054-iihgc5nr	151	9	-	-	JJ
cord-260054-iihgc5nr	151	10	and	and	CC
cord-260054-iihgc5nr	151	11	post	post	JJ
cord-260054-iihgc5nr	151	12	-	-	JJ
cord-260054-iihgc5nr	151	13	fusion	fusion	JJ
cord-260054-iihgc5nr	151	14	conformations	conformation	NNS
cord-260054-iihgc5nr	151	15	.	.	.
cord-260054-iihgc5nr	152	1	Amino	amino	NN
cord-260054-iihgc5nr	152	2	acid	acid	NN
cord-260054-iihgc5nr	152	3	Pre	pre	JJ
cord-260054-iihgc5nr	152	4	-	-	JJ
cord-260054-iihgc5nr	152	5	fusion	fusion	JJ
cord-260054-iihgc5nr	152	6	Post	Post	NNP
cord-260054-iihgc5nr	152	7	-	-	NN
cord-260054-iihgc5nr	152	8	fusion	fusion	NN
cord-260054-iihgc5nr	152	9	I929	I929	''
cord-260054-iihgc5nr	152	10	exposed	expose	VBN
cord-260054-iihgc5nr	152	11	partly	partly	RB
cord-260054-iihgc5nr	152	12	buried	bury	VBN
cord-260054-iihgc5nr	152	13	(	(	-LRB-
cord-260054-iihgc5nr	152	14	18.6	18.6	CD
cord-260054-iihgc5nr	152	15	%	%	NN
cord-260054-iihgc5nr	152	16	)	)	-RRB-
cord-260054-iihgc5nr	153	1	a	a	DT
cord-260054-iihgc5nr	153	2	Y936	y936	CD
cord-260054-iihgc5nr	153	3	exposed	expose	VBN
cord-260054-iihgc5nr	153	4	partly	partly	RB
cord-260054-iihgc5nr	153	5	buried	bury	VBN
cord-260054-iihgc5nr	153	6	(	(	-LRB-
cord-260054-iihgc5nr	153	7	19.0	19.0	CD
cord-260054-iihgc5nr	153	8	%	%	NN
cord-260054-iihgc5nr	154	1	)	)	-RRB-
cord-260054-iihgc5nr	154	2	F938	f938	CD
cord-260054-iihgc5nr	154	3	buried	bury	VBN
cord-260054-iihgc5nr	154	4	(	(	-LRB-
cord-260054-iihgc5nr	154	5	95.8	95.8	CD
cord-260054-iihgc5nr	154	6	%	%	NN
cord-260054-iihgc5nr	154	7	)	)	-RRB-
cord-260054-iihgc5nr	154	8	buried	bury	VBN
cord-260054-iihgc5nr	154	9	(	(	-LRB-
cord-260054-iihgc5nr	154	10	95.3	95.3	CD
cord-260054-iihgc5nr	154	11	%	%	NN
cord-260054-iihgc5nr	154	12	)	)	-RRB-
cord-260054-iihgc5nr	155	1	F939	F939	NNS
cord-260054-iihgc5nr	155	2	exposed	expose	VBD
cord-260054-iihgc5nr	155	3	exposed	expose	VBN
cord-260054-iihgc5nr	155	4	F940	f940	CD
cord-260054-iihgc5nr	155	5	exposed	expose	VBN
cord-260054-iihgc5nr	155	6	buried	bury	VBN
cord-260054-iihgc5nr	155	7	(	(	-LRB-
cord-260054-iihgc5nr	155	8	62.3	62.3	CD
cord-260054-iihgc5nr	155	9	%	%	NN
cord-260054-iihgc5nr	155	10	)	)	-RRB-
cord-260054-iihgc5nr	155	11	Table	table	NN
cord-260054-iihgc5nr	155	12	S1	s1	NN
cord-260054-iihgc5nr	155	13	.	.	.
cord-260054-iihgc5nr	156	1	List	list	NN
cord-260054-iihgc5nr	156	2	of	of	IN
cord-260054-iihgc5nr	156	3	mutations	mutation	NNS
cord-260054-iihgc5nr	156	4	identified	identify	VBN
cord-260054-iihgc5nr	156	5	in	in	IN
cord-260054-iihgc5nr	156	6	GISAID	GISAID	NNP
cord-260054-iihgc5nr	156	7	in	in	IN
cord-260054-iihgc5nr	156	8	at	at	RB
cord-260054-iihgc5nr	156	9	least	least	JJS
cord-260054-iihgc5nr	156	10	2	2	CD
cord-260054-iihgc5nr	156	11	identical	identical	JJ
cord-260054-iihgc5nr	156	12	sequences	sequence	NNS
cord-260054-iihgc5nr	156	13	on	on	IN
cord-260054-iihgc5nr	156	14	April	April	NNP
cord-260054-iihgc5nr	156	15	21	21	CD
cord-260054-iihgc5nr	156	16	st	st	NNP
cord-260054-iihgc5nr	156	17	2020	2020	CD
cord-260054-iihgc5nr	156	18	,	,	,
cord-260054-iihgc5nr	156	19	in	in	IN
cord-260054-iihgc5nr	156	20	sequential	sequential	JJ
cord-260054-iihgc5nr	156	21	order	order	NN
cord-260054-iihgc5nr	156	22	.	.	.
cord-260054-iihgc5nr	157	1	A	a	DT
cord-260054-iihgc5nr	157	2	pneumonia	pneumonia	NN
cord-260054-iihgc5nr	157	3	outbreak	outbreak	NN
cord-260054-iihgc5nr	157	4	associated	associate	VBN
cord-260054-iihgc5nr	157	5	with	with	IN
cord-260054-iihgc5nr	157	6	a	a	DT
cord-260054-iihgc5nr	157	7	new	new	JJ
cord-260054-iihgc5nr	157	8	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	157	9	of	of	IN
cord-260054-iihgc5nr	157	10	probable	probable	JJ
cord-260054-iihgc5nr	157	11	bat	bat	NN
cord-260054-iihgc5nr	157	12	origin	origin	NN
cord-260054-iihgc5nr	158	1	A	a	DT
cord-260054-iihgc5nr	158	2	new	new	JJ
cord-260054-iihgc5nr	158	3	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	158	4	associated	associate	VBN
cord-260054-iihgc5nr	158	5	with	with	IN
cord-260054-iihgc5nr	158	6	human	human	JJ
cord-260054-iihgc5nr	158	7	respiratory	respiratory	JJ
cord-260054-iihgc5nr	158	8	disease	disease	NN
cord-260054-iihgc5nr	158	9	in	in	IN
cord-260054-iihgc5nr	158	10	China	China	NNP
cord-260054-iihgc5nr	158	11	Clinical	clinical	JJ
cord-260054-iihgc5nr	158	12	features	feature	NNS
cord-260054-iihgc5nr	158	13	of	of	IN
cord-260054-iihgc5nr	158	14	patients	patient	NNS
cord-260054-iihgc5nr	158	15	infected	infect	VBN
cord-260054-iihgc5nr	158	16	with	with	IN
cord-260054-iihgc5nr	158	17	2019	2019	CD
cord-260054-iihgc5nr	158	18	novel	novel	JJ
cord-260054-iihgc5nr	158	19	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	158	20	in	in	IN
cord-260054-iihgc5nr	158	21	Wuhan	Wuhan	NNP
cord-260054-iihgc5nr	158	22	Receptor	Receptor	NNP
cord-260054-iihgc5nr	158	23	recognition	recognition	NN
cord-260054-iihgc5nr	158	24	mechanisms	mechanism	NNS
cord-260054-iihgc5nr	158	25	of	of	IN
cord-260054-iihgc5nr	158	26	coronaviruses	coronaviruse	NNS
cord-260054-iihgc5nr	158	27	:	:	:
cord-260054-iihgc5nr	158	28	a	a	DT
cord-260054-iihgc5nr	158	29	decade	decade	NN
cord-260054-iihgc5nr	158	30	of	of	IN
cord-260054-iihgc5nr	158	31	structural	structural	JJ
cord-260054-iihgc5nr	158	32	studies	study	NNS
cord-260054-iihgc5nr	158	33	Activation	Activation	NNP
cord-260054-iihgc5nr	158	34	of	of	IN
cord-260054-iihgc5nr	158	35	the	the	DT
cord-260054-iihgc5nr	158	36	SARS	SARS	NNP
cord-260054-iihgc5nr	158	37	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	158	38	spike	spike	NN
cord-260054-iihgc5nr	158	39	protein	protein	NN
cord-260054-iihgc5nr	158	40	via	via	IN
cord-260054-iihgc5nr	158	41	sequential	sequential	JJ
cord-260054-iihgc5nr	158	42	proteolytic	proteolytic	JJ
cord-260054-iihgc5nr	158	43	cleavage	cleavage	NN
cord-260054-iihgc5nr	158	44	at	at	IN
cord-260054-iihgc5nr	158	45	two	two	CD
cord-260054-iihgc5nr	158	46	distinct	distinct	JJ
cord-260054-iihgc5nr	158	47	sites	site	NNS
cord-260054-iihgc5nr	158	48	Host	host	NN
cord-260054-iihgc5nr	158	49	cell	cell	NN
cord-260054-iihgc5nr	158	50	entry	entry	NN
cord-260054-iihgc5nr	158	51	of	of	IN
cord-260054-iihgc5nr	158	52	Middle	Middle	NNP
cord-260054-iihgc5nr	158	53	East	East	NNP
cord-260054-iihgc5nr	158	54	respiratory	respiratory	JJ
cord-260054-iihgc5nr	158	55	syndrome	syndrome	NN
cord-260054-iihgc5nr	158	56	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	158	57	after	after	IN
cord-260054-iihgc5nr	158	58	two	two	CD
cord-260054-iihgc5nr	158	59	-	-	HYPH
cord-260054-iihgc5nr	158	60	step	step	NN
cord-260054-iihgc5nr	158	61	,	,	,
cord-260054-iihgc5nr	158	62	furin	furin	NN
cord-260054-iihgc5nr	158	63	-	-	HYPH
cord-260054-iihgc5nr	158	64	mediated	mediate	VBN
cord-260054-iihgc5nr	158	65	activation	activation	NN
cord-260054-iihgc5nr	158	66	of	of	IN
cord-260054-iihgc5nr	158	67	the	the	DT
cord-260054-iihgc5nr	158	68	spike	spike	NN
cord-260054-iihgc5nr	158	69	protein	protein	NN
cord-260054-iihgc5nr	158	70	Cell	cell	NN
cord-260054-iihgc5nr	158	71	entry	entry	NN
cord-260054-iihgc5nr	158	72	mechanisms	mechanism	NNS
cord-260054-iihgc5nr	158	73	of	of	IN
cord-260054-iihgc5nr	158	74	SARS	SARS	NNP
cord-260054-iihgc5nr	158	75	-	-	HYPH
cord-260054-iihgc5nr	158	76	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	158	77	SARS	SARS	NNP
cord-260054-iihgc5nr	158	78	-	-	HYPH
cord-260054-iihgc5nr	158	79	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	158	80	SPIKE	spike	NN
cord-260054-iihgc5nr	158	81	PROTEIN	protein	NN
cord-260054-iihgc5nr	158	82	:	:	:
cord-260054-iihgc5nr	158	83	an	an	DT
cord-260054-iihgc5nr	158	84	optimal	optimal	JJ
cord-260054-iihgc5nr	158	85	immunological	immunological	JJ
cord-260054-iihgc5nr	158	86	target	target	NN
cord-260054-iihgc5nr	158	87	for	for	IN
cord-260054-iihgc5nr	158	88	vaccines	vaccine	NNS
cord-260054-iihgc5nr	158	89	The	the	DT
cord-260054-iihgc5nr	158	90	spike	spike	NN
cord-260054-iihgc5nr	158	91	protein	protein	NN
cord-260054-iihgc5nr	158	92	of	of	IN
cord-260054-iihgc5nr	158	93	SARS	SARS	NNP
cord-260054-iihgc5nr	158	94	-	-	HYPH
cord-260054-iihgc5nr	158	95	CoV	CoV	NNP
cord-260054-iihgc5nr	158	96	--	--	:
cord-260054-iihgc5nr	158	97	a	a	DT
cord-260054-iihgc5nr	158	98	target	target	NN
cord-260054-iihgc5nr	158	99	for	for	IN
cord-260054-iihgc5nr	158	100	vaccine	vaccine	NN
cord-260054-iihgc5nr	158	101	and	and	CC
cord-260054-iihgc5nr	158	102	therapeutic	therapeutic	JJ
cord-260054-iihgc5nr	158	103	development	development	NN
cord-260054-iihgc5nr	158	104	Key	key	JJ
cord-260054-iihgc5nr	158	105	residues	residue	NNS
cord-260054-iihgc5nr	158	106	of	of	IN
cord-260054-iihgc5nr	158	107	the	the	DT
cord-260054-iihgc5nr	158	108	receptor	receptor	NN
cord-260054-iihgc5nr	158	109	binding	bind	VBG
cord-260054-iihgc5nr	158	110	motif	motif	NN
cord-260054-iihgc5nr	158	111	in	in	IN
cord-260054-iihgc5nr	158	112	the	the	DT
cord-260054-iihgc5nr	158	113	spike	spike	NN
cord-260054-iihgc5nr	158	114	protein	protein	NN
cord-260054-iihgc5nr	158	115	of	of	IN
cord-260054-iihgc5nr	158	116	SARS	SARS	NNP
cord-260054-iihgc5nr	158	117	-	-	:
cord-260054-iihgc5nr	158	118	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	158	119	that	that	WDT
cord-260054-iihgc5nr	158	120	interact	interact	VBP
cord-260054-iihgc5nr	158	121	with	with	IN
cord-260054-iihgc5nr	158	122	ACE2	ACE2	NNP
cord-260054-iihgc5nr	158	123	and	and	CC
cord-260054-iihgc5nr	158	124	neutralizing	neutralize	VBG
cord-260054-iihgc5nr	158	125	antibodies	antibody	NNS
cord-260054-iihgc5nr	159	1	Potent	potent	JJ
cord-260054-iihgc5nr	159	2	binding	binding	NN
cord-260054-iihgc5nr	159	3	of	of	IN
cord-260054-iihgc5nr	159	4	2019	2019	CD
cord-260054-iihgc5nr	159	5	novel	novel	JJ
cord-260054-iihgc5nr	159	6	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	159	7	spike	spike	NN
cord-260054-iihgc5nr	159	8	protein	protein	NN
cord-260054-iihgc5nr	159	9	by	by	IN
cord-260054-iihgc5nr	159	10	a	a	DT
cord-260054-iihgc5nr	159	11	SARS	SARS	NNP
cord-260054-iihgc5nr	159	12	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	159	13	-	-	HYPH
cord-260054-iihgc5nr	159	14	specific	specific	JJ
cord-260054-iihgc5nr	159	15	human	human	JJ
cord-260054-iihgc5nr	159	16	monoclonal	monoclonal	JJ
cord-260054-iihgc5nr	159	17	antibody	antibody	NN
cord-260054-iihgc5nr	159	18	2020	2020	CD
cord-260054-iihgc5nr	159	19	)	)	-RRB-
cord-260054-iihgc5nr	160	1	A	a	DT
cord-260054-iihgc5nr	160	2	human	human	JJ
cord-260054-iihgc5nr	160	3	monoclonal	monoclonal	JJ
cord-260054-iihgc5nr	160	4	antibody	antibody	NN
cord-260054-iihgc5nr	160	5	blocking	block	VBG
cord-260054-iihgc5nr	160	6	SARS	SARS	NNP
cord-260054-iihgc5nr	160	7	-	-	HYPH
cord-260054-iihgc5nr	160	8	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	160	9	infection	infection	NN
cord-260054-iihgc5nr	160	10	Candidate	candidate	NN
cord-260054-iihgc5nr	160	11	drugs	drug	NNS
cord-260054-iihgc5nr	160	12	against	against	IN
cord-260054-iihgc5nr	160	13	SARS	SARS	NNP
cord-260054-iihgc5nr	160	14	-	-	HYPH
cord-260054-iihgc5nr	160	15	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	160	16	and	and	CC
cord-260054-iihgc5nr	160	17	COVID-19	COVID-19	NNP
cord-260054-iihgc5nr	160	18	SARS	SARS	NNP
cord-260054-iihgc5nr	160	19	-	-	HYPH
cord-260054-iihgc5nr	160	20	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	160	21	Vaccines	vaccine	NNS
cord-260054-iihgc5nr	160	22	:	:	:
cord-260054-iihgc5nr	160	23	Status	Status	NNP
cord-260054-iihgc5nr	160	24	Report	Report	NNP
cord-260054-iihgc5nr	160	25	.	.	.
cord-260054-iihgc5nr	161	1	Immunity	Immunity	NNP
cord-260054-iihgc5nr	161	2	Ready	Ready	NNP
cord-260054-iihgc5nr	161	3	,	,	,
cord-260054-iihgc5nr	161	4	set	set	VBN
cord-260054-iihgc5nr	161	5	,	,	,
cord-260054-iihgc5nr	161	6	fuse	fuse	NN
cord-260054-iihgc5nr	161	7	!	!	.
cord-260054-iihgc5nr	162	1	The	the	DT
cord-260054-iihgc5nr	162	2	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	162	3	spike	spike	NN
cord-260054-iihgc5nr	162	4	protein	protein	NN
cord-260054-iihgc5nr	162	5	and	and	CC
cord-260054-iihgc5nr	162	6	acquisition	acquisition	NN
cord-260054-iihgc5nr	162	7	of	of	IN
cord-260054-iihgc5nr	162	8	fusion	fusion	NN
cord-260054-iihgc5nr	162	9	competence	competence	NN
cord-260054-iihgc5nr	162	10	Structure	Structure	NNP
cord-260054-iihgc5nr	162	11	of	of	IN
cord-260054-iihgc5nr	162	12	SARS	SARS	NNP
cord-260054-iihgc5nr	162	13	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	162	14	spike	spike	NN
cord-260054-iihgc5nr	162	15	receptor	receptor	NN
cord-260054-iihgc5nr	162	16	-	-	HYPH
cord-260054-iihgc5nr	162	17	binding	bind	VBG
cord-260054-iihgc5nr	162	18	domain	domain	NN
cord-260054-iihgc5nr	162	19	complexed	complexe	VBN
cord-260054-iihgc5nr	162	20	with	with	IN
cord-260054-iihgc5nr	162	21	receptor	receptor	NN
cord-260054-iihgc5nr	162	22	Structure	Structure	NNP
cord-260054-iihgc5nr	162	23	of	of	IN
cord-260054-iihgc5nr	162	24	MERS	MERS	NNP
cord-260054-iihgc5nr	162	25	-	-	HYPH
cord-260054-iihgc5nr	162	26	CoV	CoV	NNP
cord-260054-iihgc5nr	162	27	spike	spike	NN
cord-260054-iihgc5nr	162	28	receptor	receptor	NN
cord-260054-iihgc5nr	162	29	-	-	HYPH
cord-260054-iihgc5nr	162	30	binding	bind	VBG
cord-260054-iihgc5nr	162	31	domain	domain	NN
cord-260054-iihgc5nr	162	32	complexed	complexe	VBN
cord-260054-iihgc5nr	162	33	with	with	IN
cord-260054-iihgc5nr	162	34	human	human	JJ
cord-260054-iihgc5nr	162	35	receptor	receptor	NN
cord-260054-iihgc5nr	162	36	DPP4	DPP4	NNP
cord-260054-iihgc5nr	162	37	Tectonic	tectonic	JJ
cord-260054-iihgc5nr	162	38	conformational	conformational	JJ
cord-260054-iihgc5nr	162	39	changes	change	NNS
cord-260054-iihgc5nr	162	40	of	of	IN
cord-260054-iihgc5nr	162	41	a	a	DT
cord-260054-iihgc5nr	162	42	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	162	43	spike	spike	NN
cord-260054-iihgc5nr	162	44	glycoprotein	glycoprotein	NN
cord-260054-iihgc5nr	162	45	promote	promote	VBP
cord-260054-iihgc5nr	162	46	membrane	membrane	NN
cord-260054-iihgc5nr	162	47	fusion	fusion	NN
cord-260054-iihgc5nr	162	48	2017	2017	CD
cord-260054-iihgc5nr	162	49	)	)	-RRB-
cord-260054-iihgc5nr	163	1	Data	datum	NNS
cord-260054-iihgc5nr	163	2	,	,	,
cord-260054-iihgc5nr	163	3	disease	disease	NN
cord-260054-iihgc5nr	163	4	and	and	CC
cord-260054-iihgc5nr	163	5	diplomacy	diplomacy	NN
cord-260054-iihgc5nr	163	6	:	:	:
cord-260054-iihgc5nr	163	7	GISAID	GISAID	NNP
cord-260054-iihgc5nr	163	8	's	's	POS
cord-260054-iihgc5nr	163	9	innovative	innovative	JJ
cord-260054-iihgc5nr	163	10	contribution	contribution	NN
cord-260054-iihgc5nr	163	11	to	to	IN
cord-260054-iihgc5nr	163	12	global	global	JJ
cord-260054-iihgc5nr	163	13	health	health	NN
cord-260054-iihgc5nr	163	14	GISAID	GISAID	NNP
cord-260054-iihgc5nr	163	15	:	:	:
cord-260054-iihgc5nr	164	1	Global	global	JJ
cord-260054-iihgc5nr	164	2	initiative	initiative	NN
cord-260054-iihgc5nr	164	3	on	on	IN
cord-260054-iihgc5nr	164	4	sharing	share	VBG
cord-260054-iihgc5nr	164	5	all	all	DT
cord-260054-iihgc5nr	164	6	influenza	influenza	NN
cord-260054-iihgc5nr	164	7	data	datum	NNS
cord-260054-iihgc5nr	165	1	-from	-from	JJ
cord-260054-iihgc5nr	165	2	vision	vision	NN
cord-260054-iihgc5nr	165	3	to	to	IN
cord-260054-iihgc5nr	165	4	reality	reality	NN
cord-260054-iihgc5nr	166	1	The	the	DT
cord-260054-iihgc5nr	166	2	Protein	Protein	NNP
cord-260054-iihgc5nr	166	3	Data	Data	NNP
cord-260054-iihgc5nr	166	4	Bank	Bank	NNP
cord-260054-iihgc5nr	166	5	Cryo	Cryo	NNP
cord-260054-iihgc5nr	166	6	-	-	HYPH
cord-260054-iihgc5nr	166	7	EM	EM	NNP
cord-260054-iihgc5nr	166	8	structure	structure	NN
cord-260054-iihgc5nr	166	9	of	of	IN
cord-260054-iihgc5nr	166	10	the	the	DT
cord-260054-iihgc5nr	166	11	2019-nCoV	2019-ncov	CD
cord-260054-iihgc5nr	166	12	spike	spike	NN
cord-260054-iihgc5nr	166	13	in	in	IN
cord-260054-iihgc5nr	166	14	the	the	DT
cord-260054-iihgc5nr	166	15	prefusion	prefusion	NN
cord-260054-iihgc5nr	166	16	conformation	conformation	NNP
cord-260054-iihgc5nr	166	17	2020	2020	CD
cord-260054-iihgc5nr	166	18	)	)	-RRB-
cord-260054-iihgc5nr	167	1	Structure	structure	NN
cord-260054-iihgc5nr	167	2	,	,	,
cord-260054-iihgc5nr	167	3	Function	Function	NNP
cord-260054-iihgc5nr	167	4	,	,	,
cord-260054-iihgc5nr	167	5	and	and	CC
cord-260054-iihgc5nr	167	6	Antigenicity	Antigenicity	NNP
cord-260054-iihgc5nr	167	7	of	of	IN
cord-260054-iihgc5nr	167	8	the	the	DT
cord-260054-iihgc5nr	167	9	SARS	SARS	NNP
cord-260054-iihgc5nr	167	10	-	-	HYPH
cord-260054-iihgc5nr	167	11	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	167	12	Spike	Spike	NNP
cord-260054-iihgc5nr	167	13	Glycoprotein	Glycoprotein	NNP
cord-260054-iihgc5nr	167	14	Structure	Structure	NNP
cord-260054-iihgc5nr	167	15	of	of	IN
cord-260054-iihgc5nr	167	16	the	the	DT
cord-260054-iihgc5nr	167	17	SARS	SARS	NNP
cord-260054-iihgc5nr	167	18	-	-	HYPH
cord-260054-iihgc5nr	167	19	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	167	20	spike	spike	NN
cord-260054-iihgc5nr	167	21	receptorbinding	receptorbinding	NN
cord-260054-iihgc5nr	167	22	domain	domain	NN
cord-260054-iihgc5nr	167	23	bound	bind	VBN
cord-260054-iihgc5nr	167	24	to	to	IN
cord-260054-iihgc5nr	167	25	the	the	DT
cord-260054-iihgc5nr	167	26	ACE2	ACE2	NNP
cord-260054-iihgc5nr	167	27	receptor	receptor	NN
cord-260054-iihgc5nr	167	28	Structural	structural	JJ
cord-260054-iihgc5nr	167	29	basis	basis	NN
cord-260054-iihgc5nr	167	30	for	for	IN
cord-260054-iihgc5nr	167	31	the	the	DT
cord-260054-iihgc5nr	167	32	recognition	recognition	NN
cord-260054-iihgc5nr	167	33	of	of	IN
cord-260054-iihgc5nr	167	34	SARS	SARS	NNP
cord-260054-iihgc5nr	167	35	-	-	HYPH
cord-260054-iihgc5nr	167	36	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	167	37	by	by	IN
cord-260054-iihgc5nr	167	38	full	full	JJ
cord-260054-iihgc5nr	167	39	-	-	HYPH
cord-260054-iihgc5nr	167	40	length	length	NN
cord-260054-iihgc5nr	167	41	human	human	JJ
cord-260054-iihgc5nr	167	42	ACE2	ACE2	NNP
cord-260054-iihgc5nr	167	43	Structural	Structural	NNP
cord-260054-iihgc5nr	167	44	and	and	CC
cord-260054-iihgc5nr	167	45	Functional	Functional	NNP
cord-260054-iihgc5nr	167	46	Basis	Basis	NNP
cord-260054-iihgc5nr	167	47	of	of	IN
cord-260054-iihgc5nr	167	48	SARS	SARS	NNP
cord-260054-iihgc5nr	167	49	-	-	HYPH
cord-260054-iihgc5nr	167	50	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	167	51	Entry	Entry	NNP
cord-260054-iihgc5nr	167	52	by	by	IN
cord-260054-iihgc5nr	167	53	Using	use	VBG
cord-260054-iihgc5nr	167	54	Human	Human	NNP
cord-260054-iihgc5nr	167	55	ACE2	ACE2	NNP
cord-260054-iihgc5nr	167	56	2020	2020	CD
cord-260054-iihgc5nr	167	57	)	)	-RRB-
cord-260054-iihgc5nr	168	1	Structural	structural	JJ
cord-260054-iihgc5nr	168	2	basis	basis	NN
cord-260054-iihgc5nr	168	3	of	of	IN
cord-260054-iihgc5nr	168	4	receptor	receptor	NN
cord-260054-iihgc5nr	168	5	recognition	recognition	NN
cord-260054-iihgc5nr	168	6	by	by	IN
cord-260054-iihgc5nr	168	7	SARS	SARS	NNP
cord-260054-iihgc5nr	168	8	-	-	HYPH
cord-260054-iihgc5nr	168	9	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	168	10	A	a	DT
cord-260054-iihgc5nr	168	11	highly	highly	RB
cord-260054-iihgc5nr	168	12	conserved	conserved	JJ
cord-260054-iihgc5nr	168	13	cryptic	cryptic	JJ
cord-260054-iihgc5nr	168	14	epitope	epitope	NN
cord-260054-iihgc5nr	168	15	in	in	IN
cord-260054-iihgc5nr	168	16	the	the	DT
cord-260054-iihgc5nr	168	17	receptor	receptor	NN
cord-260054-iihgc5nr	168	18	binding	bind	VBG
cord-260054-iihgc5nr	168	19	domains	domain	NNS
cord-260054-iihgc5nr	168	20	of	of	IN
cord-260054-iihgc5nr	168	21	SARS	SARS	NNP
cord-260054-iihgc5nr	168	22	-	-	HYPH
cord-260054-iihgc5nr	168	23	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	168	24	and	and	CC
cord-260054-iihgc5nr	168	25	SARS	SARS	NNP
cord-260054-iihgc5nr	168	26	-	-	HYPH
cord-260054-iihgc5nr	168	27	CoV	CoV	NNP
cord-260054-iihgc5nr	168	28	Inhibition	Inhibition	NNP
cord-260054-iihgc5nr	168	29	of	of	IN
cord-260054-iihgc5nr	168	30	SARS	SARS	NNP
cord-260054-iihgc5nr	168	31	-	-	HYPH
cord-260054-iihgc5nr	168	32	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	168	33	(	(	-LRB-
cord-260054-iihgc5nr	168	34	previously	previously	RB
cord-260054-iihgc5nr	168	35	2019-nCoV	2019-ncov	CD
cord-260054-iihgc5nr	168	36	)	)	-RRB-
cord-260054-iihgc5nr	168	37	infection	infection	NN
cord-260054-iihgc5nr	168	38	by	by	IN
cord-260054-iihgc5nr	168	39	a	a	DT
cord-260054-iihgc5nr	168	40	highly	highly	RB
cord-260054-iihgc5nr	168	41	potent	potent	JJ
cord-260054-iihgc5nr	168	42	pan	pan	JJ
cord-260054-iihgc5nr	168	43	-	-	JJ
cord-260054-iihgc5nr	168	44	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	168	45	fusion	fusion	NN
cord-260054-iihgc5nr	168	46	inhibitor	inhibitor	NN
cord-260054-iihgc5nr	168	47	targeting	target	VBG
cord-260054-iihgc5nr	168	48	its	-PRON-	PRP$
cord-260054-iihgc5nr	168	49	spike	spike	NN
cord-260054-iihgc5nr	168	50	protein	protein	NN
cord-260054-iihgc5nr	168	51	that	that	WDT
cord-260054-iihgc5nr	168	52	harbors	harbor	VBZ
cord-260054-iihgc5nr	168	53	a	a	DT
cord-260054-iihgc5nr	168	54	high	high	JJ
cord-260054-iihgc5nr	168	55	capacity	capacity	NN
cord-260054-iihgc5nr	168	56	to	to	TO
cord-260054-iihgc5nr	168	57	mediate	mediate	VB
cord-260054-iihgc5nr	168	58	membrane	membrane	NN
cord-260054-iihgc5nr	168	59	fusion	fusion	NN
cord-260054-iihgc5nr	168	60	Identification	identification	NN
cord-260054-iihgc5nr	168	61	of	of	IN
cord-260054-iihgc5nr	168	62	a	a	DT
cord-260054-iihgc5nr	168	63	novel	novel	JJ
cord-260054-iihgc5nr	168	64	coronavirus	coronavirus	NN
cord-260054-iihgc5nr	168	65	causing	cause	VBG
cord-260054-iihgc5nr	168	66	severe	severe	JJ
cord-260054-iihgc5nr	168	67	pneumonia	pneumonia	NN
cord-260054-iihgc5nr	168	68	in	in	IN
cord-260054-iihgc5nr	168	69	human	human	NN
cord-260054-iihgc5nr	168	70	:	:	:
cord-260054-iihgc5nr	168	71	a	a	DT
cord-260054-iihgc5nr	168	72	descriptive	descriptive	JJ
cord-260054-iihgc5nr	168	73	study	study	NN
cord-260054-iihgc5nr	168	74	Fusion	fusion	NN
cord-260054-iihgc5nr	168	75	mechanism	mechanism	NN
cord-260054-iihgc5nr	168	76	of	of	IN
cord-260054-iihgc5nr	168	77	2019-nCoV	2019-ncov	CD
cord-260054-iihgc5nr	168	78	and	and	CC
cord-260054-iihgc5nr	168	79	fusion	fusion	NN
cord-260054-iihgc5nr	168	80	inhibitors	inhibitor	NNS
cord-260054-iihgc5nr	168	81	targeting	target	VBG
cord-260054-iihgc5nr	168	82	HR1	HR1	NNP
cord-260054-iihgc5nr	168	83	domain	domain	NN
cord-260054-iihgc5nr	168	84	in	in	IN
cord-260054-iihgc5nr	168	85	spike	spike	NN
cord-260054-iihgc5nr	168	86	protein	protein	NN
cord-260054-iihgc5nr	168	87	CD	cd	NN
cord-260054-iihgc5nr	168	88	-	-	HYPH
cord-260054-iihgc5nr	168	89	HIT	HIT	NNP
cord-260054-iihgc5nr	168	90	:	:	:
cord-260054-iihgc5nr	168	91	accelerated	accelerate	VBN
cord-260054-iihgc5nr	168	92	for	for	IN
cord-260054-iihgc5nr	168	93	clustering	cluster	VBG
cord-260054-iihgc5nr	168	94	the	the	DT
cord-260054-iihgc5nr	168	95	next	next	JJ
cord-260054-iihgc5nr	168	96	-	-	HYPH
cord-260054-iihgc5nr	168	97	generation	generation	NN
cord-260054-iihgc5nr	168	98	sequencing	sequencing	NN
cord-260054-iihgc5nr	168	99	data	datum	NNS
cord-260054-iihgc5nr	168	100	Comparative	Comparative	NNP
cord-260054-iihgc5nr	168	101	protein	protein	NN
cord-260054-iihgc5nr	168	102	modelling	modelling	NN
cord-260054-iihgc5nr	168	103	by	by	IN
cord-260054-iihgc5nr	168	104	satisfaction	satisfaction	NN
cord-260054-iihgc5nr	168	105	of	of	IN
cord-260054-iihgc5nr	168	106	spatial	spatial	JJ
cord-260054-iihgc5nr	168	107	restraints	restraint	NNS
cord-260054-iihgc5nr	168	108	Modeling	model	VBG
cord-260054-iihgc5nr	168	109	mutations	mutation	NNS
cord-260054-iihgc5nr	168	110	in	in	IN
cord-260054-iihgc5nr	168	111	protein	protein	NN
cord-260054-iihgc5nr	168	112	structures	structure	NNS
cord-260054-iihgc5nr	168	113	COCOMAPS	COCOMAPS	NNP
cord-260054-iihgc5nr	168	114	:	:	:
cord-260054-iihgc5nr	168	115	a	a	DT
cord-260054-iihgc5nr	168	116	web	web	NN
cord-260054-iihgc5nr	168	117	application	application	NN
cord-260054-iihgc5nr	168	118	to	to	TO
cord-260054-iihgc5nr	168	119	analyze	analyze	VB
cord-260054-iihgc5nr	168	120	and	and	CC
cord-260054-iihgc5nr	168	121	visualize	visualize	VB
cord-260054-iihgc5nr	168	122	contacts	contact	NNS
cord-260054-iihgc5nr	168	123	at	at	IN
cord-260054-iihgc5nr	168	124	the	the	DT
cord-260054-iihgc5nr	168	125	interface	interface	NN
cord-260054-iihgc5nr	168	126	of	of	IN
cord-260054-iihgc5nr	168	127	biomolecular	biomolecular	JJ
cord-260054-iihgc5nr	168	128	complexes	complex	NNS
cord-260054-iihgc5nr	169	1	Could	Could	MD
cord-260054-iihgc5nr	169	2	the	the	DT
cord-260054-iihgc5nr	169	3	D614	d614	NN
cord-260054-iihgc5nr	169	4	G	g	NN
cord-260054-iihgc5nr	169	5	substitution	substitution	NN
cord-260054-iihgc5nr	169	6	in	in	IN
cord-260054-iihgc5nr	169	7	the	the	DT
cord-260054-iihgc5nr	169	8	SARS	SARS	NNP
cord-260054-iihgc5nr	169	9	-	-	HYPH
cord-260054-iihgc5nr	169	10	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	169	11	spike	spike	NN
cord-260054-iihgc5nr	169	12	(	(	-LRB-
cord-260054-iihgc5nr	169	13	S	s	NN
cord-260054-iihgc5nr	169	14	)	)	-RRB-
cord-260054-iihgc5nr	169	15	protein	protein	NN
cord-260054-iihgc5nr	169	16	be	be	VB
cord-260054-iihgc5nr	169	17	associated	associate	VBN
cord-260054-iihgc5nr	169	18	with	with	IN
cord-260054-iihgc5nr	169	19	higher	high	JJR
cord-260054-iihgc5nr	169	20	COVID-19	COVID-19	NNP
cord-260054-iihgc5nr	169	21	mortality	mortality	NN
cord-260054-iihgc5nr	169	22	?	?	.
cord-260054-iihgc5nr	170	1	Spike	spike	NN
cord-260054-iihgc5nr	170	2	mutation	mutation	NN
cord-260054-iihgc5nr	170	3	pipeline	pipeline	NN
cord-260054-iihgc5nr	170	4	reveals	reveal	VBZ
cord-260054-iihgc5nr	170	5	the	the	DT
cord-260054-iihgc5nr	170	6	emergence	emergence	NN
cord-260054-iihgc5nr	170	7	of	of	IN
cord-260054-iihgc5nr	170	8	a	a	DT
cord-260054-iihgc5nr	170	9	more	more	RBR
cord-260054-iihgc5nr	170	10	transmissible	transmissible	JJ
cord-260054-iihgc5nr	170	11	form	form	NN
cord-260054-iihgc5nr	170	12	of	of	IN
cord-260054-iihgc5nr	170	13	SARS	SARS	NNP
cord-260054-iihgc5nr	170	14	-	-	HYPH
cord-260054-iihgc5nr	170	15	CoV-2	CoV-2	NNP
cord-260054-iihgc5nr	170	16	.	.	.
cord-260054-iihgc5nr	171	1	bioRxiv	biorxiv	RB
cord-260054-iihgc5nr	172	1	Structure	structure	NN
cord-260054-iihgc5nr	172	2	validation	validation	NN
cord-260054-iihgc5nr	172	3	by	by	IN
cord-260054-iihgc5nr	172	4	Calpha	Calpha	NNP
cord-260054-iihgc5nr	172	5	geometry	geometry	NN
cord-260054-iihgc5nr	172	6	:	:	:
cord-260054-iihgc5nr	172	7	phi	phi	NNP
cord-260054-iihgc5nr	172	8	,	,	,
cord-260054-iihgc5nr	172	9	psi	psi	NNP
cord-260054-iihgc5nr	172	10	and	and	CC
cord-260054-iihgc5nr	172	11	Cbeta	Cbeta	NNP
cord-260054-iihgc5nr	172	12	deviation	deviation	NN
cord-260054-iihgc5nr	172	13	Influence	influence	NN
cord-260054-iihgc5nr	172	14	of	of	IN
cord-260054-iihgc5nr	172	15	proline	proline	NN
cord-260054-iihgc5nr	172	16	residues	residue	NNS
cord-260054-iihgc5nr	172	17	on	on	IN
cord-260054-iihgc5nr	172	18	protein	protein	NN
cord-260054-iihgc5nr	172	19	conformation	conformation	NN
cord-260054-iihgc5nr	172	20	pH	ph	NN
cord-260054-iihgc5nr	172	21	-	-	HYPH
cord-260054-iihgc5nr	172	22	induced	induce	VBN
cord-260054-iihgc5nr	172	23	denaturation	denaturation	NN
cord-260054-iihgc5nr	172	24	of	of	IN
cord-260054-iihgc5nr	172	25	proteins	protein	NNS
cord-260054-iihgc5nr	173	1	:	:	:
cord-260054-iihgc5nr	173	2	a	a	DT
cord-260054-iihgc5nr	173	3	single	single	JJ
cord-260054-iihgc5nr	173	4	salt	salt	NN
cord-260054-iihgc5nr	173	5	bridge	bridge	NN
cord-260054-iihgc5nr	173	6	contributes	contribute	VBZ
cord-260054-iihgc5nr	173	7	3	3	CD
cord-260054-iihgc5nr	173	8	-	-	SYM
cord-260054-iihgc5nr	173	9	5	5	CD
cord-260054-iihgc5nr	173	10	kcal	kcal	NNP
cord-260054-iihgc5nr	173	11	/	/	SYM
cord-260054-iihgc5nr	173	12	mol	mol	NN
cord-260054-iihgc5nr	173	13	to	to	IN
cord-260054-iihgc5nr	173	14	the	the	DT
cord-260054-iihgc5nr	173	15	free	free	JJ
cord-260054-iihgc5nr	173	16	energy	energy	NN
cord-260054-iihgc5nr	173	17	of	of	IN
cord-260054-iihgc5nr	173	18	folding	folding	NN
cord-260054-iihgc5nr	173	19	of	of	IN
cord-260054-iihgc5nr	173	20	T4	T4	NNP
cord-260054-iihgc5nr	173	21	lysozyme	lysozyme	NNP
cord-260054-iihgc5nr	174	1	Authors	author	NNS
cord-260054-iihgc5nr	174	2	declare	declare	VBP
cord-260054-iihgc5nr	174	3	no	no	DT
cord-260054-iihgc5nr	174	4	competing	compete	VBG
cord-260054-iihgc5nr	174	5	interests	interest	NNS
cord-260054-iihgc5nr	174	6	.	.	.
cord-260054-iihgc5nr	174	7	 	 	_SP