id sid tid token lemma pos cord-103345-v555a2ll 1 1 key key NN cord-103345-v555a2ll 1 2 : : : cord-103345-v555a2ll 2 1 cord-103345-v555a2ll cord-103345-v555a2ll VB cord-103345-v555a2ll 3 1 authors author NNS cord-103345-v555a2ll 3 2 : : : cord-103345-v555a2ll 3 3 Taylor Taylor NNP cord-103345-v555a2ll 3 4 , , , cord-103345-v555a2ll 3 5 Adrian Adrian NNP cord-103345-v555a2ll 3 6 ; ; : cord-103345-v555a2ll 3 7 Grapentine Grapentine NNP cord-103345-v555a2ll 3 8 , , , cord-103345-v555a2ll 3 9 Sophie Sophie NNP cord-103345-v555a2ll 3 10 ; ; : cord-103345-v555a2ll 3 11 Ichhpuniani Ichhpuniani NNP cord-103345-v555a2ll 3 12 , , , cord-103345-v555a2ll 3 13 Jasmine Jasmine NNP cord-103345-v555a2ll 3 14 ; ; : cord-103345-v555a2ll 3 15 Bakovic Bakovic NNP cord-103345-v555a2ll 3 16 , , , cord-103345-v555a2ll 4 1 Marica Marica NNP cord-103345-v555a2ll 4 2 title title NN cord-103345-v555a2ll 4 3 : : : cord-103345-v555a2ll 4 4 The the DT cord-103345-v555a2ll 4 5 novel novel JJ cord-103345-v555a2ll 4 6 roles role NNS cord-103345-v555a2ll 4 7 of of IN cord-103345-v555a2ll 4 8 choline choline NN cord-103345-v555a2ll 4 9 transporter transporter NN cord-103345-v555a2ll 4 10 - - HYPH cord-103345-v555a2ll 4 11 like like JJ cord-103345-v555a2ll 4 12 1 1 CD cord-103345-v555a2ll 4 13 and and CC cord-103345-v555a2ll 4 14 2 2 CD cord-103345-v555a2ll 4 15 in in IN cord-103345-v555a2ll 4 16 ethanolamine ethanolamine JJ cord-103345-v555a2ll 4 17 transport transport NN cord-103345-v555a2ll 4 18 date date NN cord-103345-v555a2ll 4 19 : : : cord-103345-v555a2ll 4 20 2020 2020 CD cord-103345-v555a2ll 4 21 - - HYPH cord-103345-v555a2ll 4 22 08 08 CD cord-103345-v555a2ll 4 23 - - HYPH cord-103345-v555a2ll 4 24 28 28 CD cord-103345-v555a2ll 4 25 journal journal NN cord-103345-v555a2ll 4 26 : : : cord-103345-v555a2ll 5 1 bioRxiv biorxiv IN cord-103345-v555a2ll 5 2 DOI DOI NNP cord-103345-v555a2ll 5 3 : : : cord-103345-v555a2ll 6 1 10.1101/2020.08.27.270223 10.1101/2020.08.27.270223 NNP cord-103345-v555a2ll 6 2 sha sha NNP cord-103345-v555a2ll 6 3 : : : cord-103345-v555a2ll 6 4 c928634129f71c86aa8b78f9640efd372f3060be c928634129f71c86aa8b78f9640efd372f3060be NNP cord-103345-v555a2ll 6 5 doc_id doc_id CD cord-103345-v555a2ll 6 6 : : : cord-103345-v555a2ll 6 7 103345 103345 CD cord-103345-v555a2ll 6 8 cord_uid cord_uid FW cord-103345-v555a2ll 6 9 : : : cord-103345-v555a2ll 7 1 v555a2ll v555a2ll NNP cord-103345-v555a2ll 7 2 We -PRON- PRP cord-103345-v555a2ll 7 3 examined examine VBD cord-103345-v555a2ll 7 4 a a DT cord-103345-v555a2ll 7 5 novel novel JJ cord-103345-v555a2ll 7 6 function function NN cord-103345-v555a2ll 7 7 of of IN cord-103345-v555a2ll 7 8 mammalian mammalian JJ cord-103345-v555a2ll 7 9 Choline choline NN cord-103345-v555a2ll 7 10 - - HYPH cord-103345-v555a2ll 7 11 Transporter transporter NN cord-103345-v555a2ll 7 12 - - HYPH cord-103345-v555a2ll 7 13 Like like JJ cord-103345-v555a2ll 7 14 proteins protein NNS cord-103345-v555a2ll 7 15 CTL1 CTL1 NNP cord-103345-v555a2ll 7 16 / / SYM cord-103345-v555a2ll 7 17 SLC44A1 slc44a1 NN cord-103345-v555a2ll 7 18 and and CC cord-103345-v555a2ll 7 19 CTL2 CTL2 NNP cord-103345-v555a2ll 7 20 / / SYM cord-103345-v555a2ll 7 21 SLC44A2 slc44a2 XX cord-103345-v555a2ll 7 22 in in IN cord-103345-v555a2ll 7 23 ethanolamine ethanolamine JJ cord-103345-v555a2ll 7 24 transport transport NN cord-103345-v555a2ll 7 25 . . . cord-103345-v555a2ll 8 1 We -PRON- PRP cord-103345-v555a2ll 8 2 established establish VBD cord-103345-v555a2ll 8 3 two two CD cord-103345-v555a2ll 8 4 distinct distinct JJ cord-103345-v555a2ll 8 5 ethanolamine ethanolamine NN cord-103345-v555a2ll 8 6 transport transport NN cord-103345-v555a2ll 8 7 systems system NNS cord-103345-v555a2ll 8 8 of of IN cord-103345-v555a2ll 8 9 a a DT cord-103345-v555a2ll 8 10 high high JJ cord-103345-v555a2ll 8 11 affinity affinity NN cord-103345-v555a2ll 8 12 ( ( -LRB- cord-103345-v555a2ll 8 13 K1 K1 NNP cord-103345-v555a2ll 8 14 = = SYM cord-103345-v555a2ll 8 15 55.6 55.6 CD cord-103345-v555a2ll 8 16 - - HYPH cord-103345-v555a2ll 8 17 66.5 66.5 CD cord-103345-v555a2ll 8 18 μM μM NNP cord-103345-v555a2ll 8 19 ) ) -RRB- cord-103345-v555a2ll 8 20 , , , cord-103345-v555a2ll 8 21 mediated mediate VBN cord-103345-v555a2ll 8 22 by by IN cord-103345-v555a2ll 8 23 CTL1 CTL1 NNP cord-103345-v555a2ll 8 24 , , , cord-103345-v555a2ll 8 25 and and CC cord-103345-v555a2ll 8 26 of of IN cord-103345-v555a2ll 8 27 a a DT cord-103345-v555a2ll 8 28 low low JJ cord-103345-v555a2ll 8 29 affinity affinity NN cord-103345-v555a2ll 8 30 ( ( -LRB- cord-103345-v555a2ll 8 31 K2 K2 NNP cord-103345-v555a2ll 8 32 = = SYM cord-103345-v555a2ll 8 33 275 275 CD cord-103345-v555a2ll 8 34 - - SYM cord-103345-v555a2ll 8 35 299 299 CD cord-103345-v555a2ll 8 36 μM μm CD cord-103345-v555a2ll 8 37 ) ) -RRB- cord-103345-v555a2ll 8 38 , , , cord-103345-v555a2ll 8 39 mediated mediate VBN cord-103345-v555a2ll 8 40 by by IN cord-103345-v555a2ll 8 41 CTL2 CTL2 NNP cord-103345-v555a2ll 8 42 . . . cord-103345-v555a2ll 9 1 Both both DT cord-103345-v555a2ll 9 2 types type NNS cord-103345-v555a2ll 9 3 of of IN cord-103345-v555a2ll 9 4 transport transport NN cord-103345-v555a2ll 9 5 are be VBP cord-103345-v555a2ll 9 6 Na+-independent na+-independent JJ cord-103345-v555a2ll 9 7 and and CC cord-103345-v555a2ll 9 8 mediated mediate VBN cord-103345-v555a2ll 9 9 in in IN cord-103345-v555a2ll 9 10 a a DT cord-103345-v555a2ll 9 11 pH pH NNP cord-103345-v555a2ll 9 12 dependent dependent JJ cord-103345-v555a2ll 9 13 manner manner NN cord-103345-v555a2ll 9 14 , , , cord-103345-v555a2ll 9 15 as as IN cord-103345-v555a2ll 9 16 expected expect VBN cord-103345-v555a2ll 9 17 for for IN cord-103345-v555a2ll 9 18 ethanolamine ethanolamine NN cord-103345-v555a2ll 9 19 / / SYM cord-103345-v555a2ll 9 20 H+ H+ NNP cord-103345-v555a2ll 9 21 antiporters antiporter NNS cord-103345-v555a2ll 9 22 . . . cord-103345-v555a2ll 10 1 Primary primary JJ cord-103345-v555a2ll 10 2 human human JJ cord-103345-v555a2ll 10 3 fibroblasts fibroblast NNS cord-103345-v555a2ll 10 4 with with IN cord-103345-v555a2ll 10 5 separate separate JJ cord-103345-v555a2ll 10 6 frameshift frameshift NN cord-103345-v555a2ll 10 7 mutations mutation NNS cord-103345-v555a2ll 10 8 ( ( -LRB- cord-103345-v555a2ll 10 9 M1= M1= NNP cord-103345-v555a2ll 10 10 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 10 11 ΔAsp517 ΔAsp517 NNP cord-103345-v555a2ll 10 12 and and CC cord-103345-v555a2ll 10 13 M2= M2= NNP cord-103345-v555a2ll 10 14 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 10 15 ΔSer126 δser126 NN cord-103345-v555a2ll 10 16 ) ) -RRB- cord-103345-v555a2ll 10 17 are be VBP cord-103345-v555a2ll 10 18 devoid devoid JJ cord-103345-v555a2ll 10 19 of of IN cord-103345-v555a2ll 10 20 CTL1 ctl1 JJ cord-103345-v555a2ll 10 21 ethanolamine ethanolamine NN cord-103345-v555a2ll 10 22 transport transport NN cord-103345-v555a2ll 10 23 but but CC cord-103345-v555a2ll 10 24 maintain maintain VB cord-103345-v555a2ll 10 25 unaffected unaffected JJ cord-103345-v555a2ll 10 26 CTL2 CTL2 NNP cord-103345-v555a2ll 10 27 transport transport NN cord-103345-v555a2ll 10 28 . . . cord-103345-v555a2ll 11 1 The the DT cord-103345-v555a2ll 11 2 lack lack NN cord-103345-v555a2ll 11 3 of of IN cord-103345-v555a2ll 11 4 CTL1 CTL1 NNP cord-103345-v555a2ll 11 5 or or CC cord-103345-v555a2ll 11 6 CTL2 CTL2 NNP cord-103345-v555a2ll 11 7 reduced reduce VBD cord-103345-v555a2ll 11 8 the the DT cord-103345-v555a2ll 11 9 ethanolamine ethanolamine NN cord-103345-v555a2ll 11 10 transport transport NN cord-103345-v555a2ll 11 11 , , , cord-103345-v555a2ll 11 12 the the DT cord-103345-v555a2ll 11 13 flux flux NN cord-103345-v555a2ll 11 14 by by IN cord-103345-v555a2ll 11 15 the the DT cord-103345-v555a2ll 11 16 CDP CDP NNP cord-103345-v555a2ll 11 17 - - HYPH cord-103345-v555a2ll 11 18 ethanolamine ethanolamine JJ cord-103345-v555a2ll 11 19 Kennedy Kennedy NNP cord-103345-v555a2ll 11 20 pathway pathway NN cord-103345-v555a2ll 11 21 and and CC cord-103345-v555a2ll 11 22 PE PE NNP cord-103345-v555a2ll 11 23 synthesis synthesis NN cord-103345-v555a2ll 11 24 . . . cord-103345-v555a2ll 12 1 Overexpression Overexpression NNP cord-103345-v555a2ll 12 2 of of IN cord-103345-v555a2ll 12 3 CTL1 CTL1 NNP cord-103345-v555a2ll 12 4 in in IN cord-103345-v555a2ll 12 5 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 12 6 ΔSer126 ΔSer126 NNP cord-103345-v555a2ll 12 7 ( ( -LRB- cord-103345-v555a2ll 12 8 M2 M2 NNP cord-103345-v555a2ll 12 9 ) ) -RRB- cord-103345-v555a2ll 12 10 cells cell NNS cord-103345-v555a2ll 12 11 improved improve VBD cord-103345-v555a2ll 12 12 the the DT cord-103345-v555a2ll 12 13 ethanolamine ethanolamine NN cord-103345-v555a2ll 12 14 transport transport NN cord-103345-v555a2ll 12 15 and and CC cord-103345-v555a2ll 12 16 PE PE NNP cord-103345-v555a2ll 12 17 synthesis synthesis NN cord-103345-v555a2ll 12 18 . . . cord-103345-v555a2ll 13 1 The the DT cord-103345-v555a2ll 13 2 SLC44A1 slc44a1 NN cord-103345-v555a2ll 13 3 ΔSer126 δser126 NN cord-103345-v555a2ll 13 4 cells cell NNS cord-103345-v555a2ll 13 5 are be VBP cord-103345-v555a2ll 13 6 reliant reliant JJ cord-103345-v555a2ll 13 7 on on IN cord-103345-v555a2ll 13 8 CTL2 CTL2 NNP cord-103345-v555a2ll 13 9 function function NN cord-103345-v555a2ll 13 10 and and CC cord-103345-v555a2ll 14 1 CTL2 CTL2 NNP cord-103345-v555a2ll 14 2 siRNA siRNA NNP cord-103345-v555a2ll 14 3 almost almost RB cord-103345-v555a2ll 14 4 completely completely RB cord-103345-v555a2ll 14 5 abolished abolish VBN cord-103345-v555a2ll 14 6 ethanolamine ethanolamine JJ cord-103345-v555a2ll 14 7 transport transport NN cord-103345-v555a2ll 14 8 in in IN cord-103345-v555a2ll 14 9 the the DT cord-103345-v555a2ll 14 10 whole whole JJ cord-103345-v555a2ll 14 11 cells cell NNS cord-103345-v555a2ll 14 12 and and CC cord-103345-v555a2ll 14 13 mitochondria mitochondrion NNS cord-103345-v555a2ll 14 14 . . . cord-103345-v555a2ll 15 1 Overexpression Overexpression NNP cord-103345-v555a2ll 15 2 of of IN cord-103345-v555a2ll 15 3 CTL1 CTL1 NNP cord-103345-v555a2ll 15 4 and and CC cord-103345-v555a2ll 15 5 CTL2 CTL2 NNP cord-103345-v555a2ll 15 6 cDNAs cDNAs NNPS cord-103345-v555a2ll 15 7 increased increase VBD cord-103345-v555a2ll 15 8 ethanolamine ethanolamine JJ cord-103345-v555a2ll 15 9 transport transport NN cord-103345-v555a2ll 15 10 in in IN cord-103345-v555a2ll 15 11 control control NN cord-103345-v555a2ll 15 12 and and CC cord-103345-v555a2ll 15 13 SLC44A1ΔSer126 SLC44A1ΔSer126 NNP cord-103345-v555a2ll 15 14 cells cell NNS cord-103345-v555a2ll 15 15 . . . cord-103345-v555a2ll 16 1 CTL1 CTL1 NNP cord-103345-v555a2ll 16 2 and and CC cord-103345-v555a2ll 16 3 CTL2 CTL2 NNP cord-103345-v555a2ll 16 4 facilitated facilitate VBD cord-103345-v555a2ll 16 5 mitochondrial mitochondrial JJ cord-103345-v555a2ll 16 6 ethanolamine ethanolamine NN cord-103345-v555a2ll 16 7 uptake uptake NN cord-103345-v555a2ll 16 8 , , , cord-103345-v555a2ll 16 9 but but CC cord-103345-v555a2ll 16 10 the the DT cord-103345-v555a2ll 16 11 transport transport NN cord-103345-v555a2ll 16 12 mediated mediate VBN cord-103345-v555a2ll 16 13 by by IN cord-103345-v555a2ll 16 14 CTL1 CTL1 NNP cord-103345-v555a2ll 16 15 is be VBZ cord-103345-v555a2ll 16 16 predominant predominant JJ cord-103345-v555a2ll 16 17 in in IN cord-103345-v555a2ll 16 18 the the DT cord-103345-v555a2ll 16 19 whole whole JJ cord-103345-v555a2ll 16 20 cells cell NNS cord-103345-v555a2ll 16 21 and and CC cord-103345-v555a2ll 16 22 mitochondria mitochondrion NNS cord-103345-v555a2ll 16 23 . . . cord-103345-v555a2ll 17 1 These these DT cord-103345-v555a2ll 17 2 data datum NNS cord-103345-v555a2ll 17 3 firmly firmly RB cord-103345-v555a2ll 17 4 established establish VBD cord-103345-v555a2ll 17 5 that that IN cord-103345-v555a2ll 17 6 CTL1 CTL1 NNP cord-103345-v555a2ll 17 7 and and CC cord-103345-v555a2ll 17 8 CTL2 CTL2 NNP cord-103345-v555a2ll 17 9 are be VBP cord-103345-v555a2ll 17 10 the the DT cord-103345-v555a2ll 17 11 first first JJ cord-103345-v555a2ll 17 12 identified identify VBN cord-103345-v555a2ll 17 13 ethanolamine ethanolamine NN cord-103345-v555a2ll 17 14 transporters transporter NNS cord-103345-v555a2ll 17 15 in in IN cord-103345-v555a2ll 17 16 the the DT cord-103345-v555a2ll 17 17 whole whole JJ cord-103345-v555a2ll 17 18 cells cell NNS cord-103345-v555a2ll 17 19 and and CC cord-103345-v555a2ll 17 20 mitochondria mitochondrion NNS cord-103345-v555a2ll 17 21 , , , cord-103345-v555a2ll 17 22 with with IN cord-103345-v555a2ll 17 23 intrinsic intrinsic JJ cord-103345-v555a2ll 17 24 roles role NNS cord-103345-v555a2ll 17 25 in in IN cord-103345-v555a2ll 17 26 de de NNP cord-103345-v555a2ll 17 27 novo novo NNP cord-103345-v555a2ll 17 28 PE PE NNP cord-103345-v555a2ll 17 29 synthesis synthesis NN cord-103345-v555a2ll 17 30 by by IN cord-103345-v555a2ll 17 31 the the DT cord-103345-v555a2ll 17 32 CDP CDP NNP cord-103345-v555a2ll 17 33 - - HYPH cord-103345-v555a2ll 17 34 Etn Etn NNP cord-103345-v555a2ll 17 35 Kennedy Kennedy NNP cord-103345-v555a2ll 17 36 pathway pathway NN cord-103345-v555a2ll 17 37 and and CC cord-103345-v555a2ll 17 38 compartmentation compartmentation NN cord-103345-v555a2ll 17 39 of of IN cord-103345-v555a2ll 17 40 intracellular intracellular JJ cord-103345-v555a2ll 17 41 ethanolamine ethanolamine NN cord-103345-v555a2ll 17 42 . . . cord-103345-v555a2ll 18 1 Significance significance NN cord-103345-v555a2ll 19 1 The the DT cord-103345-v555a2ll 19 2 lack lack NN cord-103345-v555a2ll 19 3 of of IN cord-103345-v555a2ll 19 4 Choline Choline NNP cord-103345-v555a2ll 19 5 Transporter Transporter NNP cord-103345-v555a2ll 19 6 Like like IN cord-103345-v555a2ll 19 7 1 1 CD cord-103345-v555a2ll 19 8 ( ( -LRB- cord-103345-v555a2ll 19 9 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 19 10 / / SYM cord-103345-v555a2ll 19 11 CTL1 CTL1 NNP cord-103345-v555a2ll 19 12 ) ) -RRB- cord-103345-v555a2ll 19 13 is be VBZ cord-103345-v555a2ll 19 14 the the DT cord-103345-v555a2ll 19 15 primary primary JJ cord-103345-v555a2ll 19 16 cause cause NN cord-103345-v555a2ll 19 17 of of IN cord-103345-v555a2ll 19 18 a a DT cord-103345-v555a2ll 19 19 new new JJ cord-103345-v555a2ll 19 20 neurodegenerative neurodegenerative JJ cord-103345-v555a2ll 19 21 disorder disorder NN cord-103345-v555a2ll 19 22 with with IN cord-103345-v555a2ll 19 23 elements element NNS cord-103345-v555a2ll 19 24 of of IN cord-103345-v555a2ll 19 25 childhood childhood NN cord-103345-v555a2ll 19 26 - - HYPH cord-103345-v555a2ll 19 27 onset onset NN cord-103345-v555a2ll 19 28 parkinsonism parkinsonism NN cord-103345-v555a2ll 19 29 and and CC cord-103345-v555a2ll 19 30 mitochondrial mitochondrial JJ cord-103345-v555a2ll 19 31 dysfunction dysfunction NN cord-103345-v555a2ll 19 32 . . . cord-103345-v555a2ll 20 1 SLC44A2/ slc44a2/ NN cord-103345-v555a2ll 21 1 CTL2 CTL2 NNP cord-103345-v555a2ll 21 2 encodes encode VBZ cord-103345-v555a2ll 21 3 the the DT cord-103345-v555a2ll 21 4 human human JJ cord-103345-v555a2ll 21 5 neutrophil neutrophil NN cord-103345-v555a2ll 21 6 antigen antigen NNP cord-103345-v555a2ll 21 7 3 3 CD cord-103345-v555a2ll 21 8 , , , cord-103345-v555a2ll 21 9 causes cause VBZ cord-103345-v555a2ll 21 10 autoimmune autoimmune JJ cord-103345-v555a2ll 21 11 hearing hearing NN cord-103345-v555a2ll 21 12 loss loss NN cord-103345-v555a2ll 21 13 and and CC cord-103345-v555a2ll 21 14 Meniere Meniere NNP cord-103345-v555a2ll 21 15 ’s ’s POS cord-103345-v555a2ll 21 16 disease disease NN cord-103345-v555a2ll 21 17 , , , cord-103345-v555a2ll 21 18 and and CC cord-103345-v555a2ll 21 19 has have VBZ cord-103345-v555a2ll 21 20 been be VBN cord-103345-v555a2ll 21 21 recently recently RB cord-103345-v555a2ll 21 22 identified identify VBN cord-103345-v555a2ll 21 23 as as IN cord-103345-v555a2ll 21 24 the the DT cord-103345-v555a2ll 21 25 main main JJ cord-103345-v555a2ll 21 26 risk risk NN cord-103345-v555a2ll 21 27 factor factor NN cord-103345-v555a2ll 21 28 for for IN cord-103345-v555a2ll 21 29 thrombosis thrombosis NN cord-103345-v555a2ll 21 30 - - : cord-103345-v555a2ll 21 31 the the DT cord-103345-v555a2ll 21 32 major major JJ cord-103345-v555a2ll 21 33 cause cause NN cord-103345-v555a2ll 21 34 of of IN cord-103345-v555a2ll 21 35 death death NN cord-103345-v555a2ll 21 36 in in IN cord-103345-v555a2ll 21 37 Covid-19 covid-19 NN cord-103345-v555a2ll 21 38 patients patient NNS cord-103345-v555a2ll 21 39 . . . cord-103345-v555a2ll 22 1 Our -PRON- PRP$ cord-103345-v555a2ll 22 2 investigation investigation NN cord-103345-v555a2ll 22 3 provides provide VBZ cord-103345-v555a2ll 22 4 insights insight NNS cord-103345-v555a2ll 22 5 into into IN cord-103345-v555a2ll 22 6 the the DT cord-103345-v555a2ll 22 7 novel novel JJ cord-103345-v555a2ll 22 8 functions function NNS cord-103345-v555a2ll 22 9 of of IN cord-103345-v555a2ll 22 10 CTL1 CTL1 NNP cord-103345-v555a2ll 22 11 and and CC cord-103345-v555a2ll 22 12 CTL2 CTL2 NNP cord-103345-v555a2ll 22 13 as as IN cord-103345-v555a2ll 22 14 intrinsic intrinsic JJ cord-103345-v555a2ll 22 15 ethanolamine ethanolamine NN cord-103345-v555a2ll 22 16 transporters transporter NNS cord-103345-v555a2ll 22 17 . . . cord-103345-v555a2ll 23 1 CTL1 CTL1 NNP cord-103345-v555a2ll 23 2 and and CC cord-103345-v555a2ll 23 3 CTL2 CTL2 NNP cord-103345-v555a2ll 23 4 are be VBP cord-103345-v555a2ll 23 5 high high JJ cord-103345-v555a2ll 23 6 and and CC cord-103345-v555a2ll 23 7 low low JJ cord-103345-v555a2ll 23 8 affinity affinity NN cord-103345-v555a2ll 23 9 transporters transporter NNS cord-103345-v555a2ll 23 10 , , , cord-103345-v555a2ll 23 11 with with IN cord-103345-v555a2ll 23 12 direct direct JJ cord-103345-v555a2ll 23 13 roles role NNS cord-103345-v555a2ll 23 14 in in IN cord-103345-v555a2ll 23 15 the the DT cord-103345-v555a2ll 23 16 membrane membrane NN cord-103345-v555a2ll 23 17 phospholipid phospholipid NN cord-103345-v555a2ll 23 18 synthesis synthesis NN cord-103345-v555a2ll 23 19 . . . cord-103345-v555a2ll 24 1 The the DT cord-103345-v555a2ll 24 2 work work NN cord-103345-v555a2ll 24 3 contributes contribute VBZ cord-103345-v555a2ll 24 4 to to IN cord-103345-v555a2ll 24 5 new new JJ cord-103345-v555a2ll 24 6 knowledge knowledge NN cord-103345-v555a2ll 24 7 for for IN cord-103345-v555a2ll 24 8 CTL1 CTL1 NNP cord-103345-v555a2ll 24 9 and and CC cord-103345-v555a2ll 24 10 CTL2 CTL2 NNP cord-103345-v555a2ll 24 11 independent independent JJ cord-103345-v555a2ll 24 12 transport transport NN cord-103345-v555a2ll 24 13 functions function NNS cord-103345-v555a2ll 24 14 and and CC cord-103345-v555a2ll 24 15 the the DT cord-103345-v555a2ll 24 16 optimization optimization NN cord-103345-v555a2ll 24 17 of of IN cord-103345-v555a2ll 24 18 prevention prevention NN cord-103345-v555a2ll 24 19 and and CC cord-103345-v555a2ll 24 20 treatment treatment NN cord-103345-v555a2ll 24 21 strategies strategy NNS cord-103345-v555a2ll 24 22 in in IN cord-103345-v555a2ll 24 23 those those DT cord-103345-v555a2ll 24 24 various various JJ cord-103345-v555a2ll 24 25 diseases disease NNS cord-103345-v555a2ll 24 26 . . . cord-103345-v555a2ll 25 1 Phosphatidylcholine Phosphatidylcholine NNP cord-103345-v555a2ll 25 2 ( ( -LRB- cord-103345-v555a2ll 25 3 PC pc NN cord-103345-v555a2ll 25 4 ) ) -RRB- cord-103345-v555a2ll 25 5 and and CC cord-103345-v555a2ll 25 6 phosphatidylethanolamine phosphatidylethanolamine NNP cord-103345-v555a2ll 25 7 ( ( -LRB- cord-103345-v555a2ll 25 8 PE PE NNP cord-103345-v555a2ll 25 9 ) ) -RRB- cord-103345-v555a2ll 25 10 are be VBP cord-103345-v555a2ll 25 11 major major JJ cord-103345-v555a2ll 25 12 components component NNS cord-103345-v555a2ll 25 13 of of IN cord-103345-v555a2ll 25 14 cellular cellular JJ cord-103345-v555a2ll 25 15 membranes membrane NNS cord-103345-v555a2ll 25 16 where where WRB cord-103345-v555a2ll 25 17 they -PRON- PRP cord-103345-v555a2ll 25 18 are be VBP cord-103345-v555a2ll 25 19 involved involve VBN cord-103345-v555a2ll 25 20 with with IN cord-103345-v555a2ll 25 21 essential essential JJ cord-103345-v555a2ll 25 22 cellular cellular JJ cord-103345-v555a2ll 25 23 processes process NNS cord-103345-v555a2ll 25 24 ( ( -LRB- cord-103345-v555a2ll 25 25 1 1 CD cord-103345-v555a2ll 25 26 , , , cord-103345-v555a2ll 25 27 2 2 CD cord-103345-v555a2ll 25 28 ) ) -RRB- cord-103345-v555a2ll 25 29 . . . cord-103345-v555a2ll 26 1 PC PC NNP cord-103345-v555a2ll 26 2 and and CC cord-103345-v555a2ll 26 3 PE PE NNP cord-103345-v555a2ll 26 4 are be VBP cord-103345-v555a2ll 26 5 synthesized synthesize VBN cord-103345-v555a2ll 26 6 de de IN cord-103345-v555a2ll 26 7 novo novo NNP cord-103345-v555a2ll 26 8 by by IN cord-103345-v555a2ll 26 9 CDP CDP NNP cord-103345-v555a2ll 26 10 - - HYPH cord-103345-v555a2ll 26 11 Cho Cho NNP cord-103345-v555a2ll 26 12 and and CC cord-103345-v555a2ll 26 13 CDP CDP NNP cord-103345-v555a2ll 26 14 - - HYPH cord-103345-v555a2ll 26 15 Etn Etn NNP cord-103345-v555a2ll 26 16 branches branch NNS cord-103345-v555a2ll 26 17 of of IN cord-103345-v555a2ll 26 18 the the DT cord-103345-v555a2ll 26 19 Kennedy Kennedy NNP cord-103345-v555a2ll 26 20 pathway pathway NN cord-103345-v555a2ll 26 21 in in IN cord-103345-v555a2ll 26 22 which which WDT cord-103345-v555a2ll 26 23 the the DT cord-103345-v555a2ll 26 24 extracellular extracellular JJ cord-103345-v555a2ll 26 25 substrates substrate NNS cord-103345-v555a2ll 26 26 choline choline NN cord-103345-v555a2ll 26 27 ( ( -LRB- cord-103345-v555a2ll 26 28 Cho Cho NNP cord-103345-v555a2ll 26 29 ) ) -RRB- cord-103345-v555a2ll 26 30 and and CC cord-103345-v555a2ll 26 31 ethanolamine ethanolamine NN cord-103345-v555a2ll 26 32 ( ( -LRB- cord-103345-v555a2ll 27 1 Etn etn CC cord-103345-v555a2ll 27 2 ) ) -RRB- cord-103345-v555a2ll 27 3 are be VBP cord-103345-v555a2ll 27 4 actively actively RB cord-103345-v555a2ll 27 5 transported transport VBN cord-103345-v555a2ll 27 6 into into IN cord-103345-v555a2ll 27 7 the the DT cord-103345-v555a2ll 27 8 cell cell NN cord-103345-v555a2ll 27 9 , , , cord-103345-v555a2ll 27 10 phosphorylated phosphorylated JJ cord-103345-v555a2ll 27 11 and and CC cord-103345-v555a2ll 27 12 coupled couple VBN cord-103345-v555a2ll 27 13 with with IN cord-103345-v555a2ll 27 14 diacylglycerols diacylglycerol NNS cord-103345-v555a2ll 27 15 ( ( -LRB- cord-103345-v555a2ll 27 16 DAG DAG NNP cord-103345-v555a2ll 27 17 ) ) -RRB- cord-103345-v555a2ll 27 18 to to TO cord-103345-v555a2ll 27 19 form form VB cord-103345-v555a2ll 27 20 the the DT cord-103345-v555a2ll 27 21 final final JJ cord-103345-v555a2ll 27 22 phospholipid phospholipid NN cord-103345-v555a2ll 27 23 product product NN cord-103345-v555a2ll 27 24 . . . cord-103345-v555a2ll 28 1 While while IN cord-103345-v555a2ll 28 2 multiple multiple JJ cord-103345-v555a2ll 28 3 transport transport NN cord-103345-v555a2ll 28 4 systems system NNS cord-103345-v555a2ll 28 5 have have VBP cord-103345-v555a2ll 28 6 been be VBN cord-103345-v555a2ll 28 7 established establish VBN cord-103345-v555a2ll 28 8 for for IN cord-103345-v555a2ll 28 9 Cho Cho NNP cord-103345-v555a2ll 28 10 , , , cord-103345-v555a2ll 28 11 Etn Etn NNP cord-103345-v555a2ll 28 12 transport transport NN cord-103345-v555a2ll 28 13 is be VBZ cord-103345-v555a2ll 28 14 poorly poorly RB cord-103345-v555a2ll 28 15 characterized characterize VBN cord-103345-v555a2ll 28 16 and and CC cord-103345-v555a2ll 28 17 there there EX cord-103345-v555a2ll 28 18 is be VBZ cord-103345-v555a2ll 28 19 no no DT cord-103345-v555a2ll 28 20 single single JJ cord-103345-v555a2ll 28 21 gene gene NN cord-103345-v555a2ll 28 22 / / SYM cord-103345-v555a2ll 28 23 protein protein NN cord-103345-v555a2ll 28 24 assigned assign VBD cord-103345-v555a2ll 28 25 a a DT cord-103345-v555a2ll 28 26 transport transport NN cord-103345-v555a2ll 28 27 function function NN cord-103345-v555a2ll 28 28 for for IN cord-103345-v555a2ll 28 29 mammalian mammalian JJ cord-103345-v555a2ll 28 30 Etn Etn NNP cord-103345-v555a2ll 28 31 . . . cord-103345-v555a2ll 29 1 Cho Cho NNP cord-103345-v555a2ll 29 2 transport transport NN cord-103345-v555a2ll 29 3 for for IN cord-103345-v555a2ll 29 4 membrane membrane NN cord-103345-v555a2ll 29 5 phospholipid phospholipid NN cord-103345-v555a2ll 29 6 synthesis synthesis NN cord-103345-v555a2ll 29 7 is be VBZ cord-103345-v555a2ll 29 8 mediated mediate VBN cord-103345-v555a2ll 29 9 by by IN cord-103345-v555a2ll 29 10 Cho Cho NNP cord-103345-v555a2ll 29 11 transporter transporter NN cord-103345-v555a2ll 29 12 like like IN cord-103345-v555a2ll 29 13 protein protein NN cord-103345-v555a2ll 29 14 CTL1 CTL1 NNP cord-103345-v555a2ll 29 15 / / SYM cord-103345-v555a2ll 29 16 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 29 17 ( ( -LRB- cord-103345-v555a2ll 29 18 3 3 CD cord-103345-v555a2ll 29 19 ) ) -RRB- cord-103345-v555a2ll 29 20 . . . cord-103345-v555a2ll 30 1 CTL1 CTL1 NNP cord-103345-v555a2ll 30 2 is be VBZ cord-103345-v555a2ll 30 3 the the DT cord-103345-v555a2ll 30 4 only only JJ cord-103345-v555a2ll 30 5 well well RB cord-103345-v555a2ll 30 6 - - HYPH cord-103345-v555a2ll 30 7 characterized characterize VBN cord-103345-v555a2ll 30 8 member member NN cord-103345-v555a2ll 30 9 of of IN cord-103345-v555a2ll 30 10 a a DT cord-103345-v555a2ll 30 11 broader broad JJR cord-103345-v555a2ll 30 12 family family NN cord-103345-v555a2ll 30 13 ( ( -LRB- cord-103345-v555a2ll 30 14 CTL1 CTL1 NNP cord-103345-v555a2ll 30 15 - - HYPH cord-103345-v555a2ll 30 16 5 5 CD cord-103345-v555a2ll 30 17 / / SYM cord-103345-v555a2ll 30 18 SLC44A1 slc44a1 NN cord-103345-v555a2ll 30 19 - - HYPH cord-103345-v555a2ll 30 20 5 5 CD cord-103345-v555a2ll 30 21 ) ) -RRB- cord-103345-v555a2ll 30 22 ( ( -LRB- cord-103345-v555a2ll 30 23 4 4 CD cord-103345-v555a2ll 30 24 , , , cord-103345-v555a2ll 30 25 5 5 CD cord-103345-v555a2ll 30 26 ) ) -RRB- cord-103345-v555a2ll 30 27 . . . cord-103345-v555a2ll 31 1 CTL1 ctl1 JJ cord-103345-v555a2ll 31 2 / / SYM cord-103345-v555a2ll 31 3 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 31 4 is be VBZ cord-103345-v555a2ll 31 5 a a DT cord-103345-v555a2ll 31 6 Cho Cho NNP cord-103345-v555a2ll 31 7 / / SYM cord-103345-v555a2ll 31 8 H h NN cord-103345-v555a2ll 31 9 + + CC cord-103345-v555a2ll 31 10 antiporter antiporter NN cord-103345-v555a2ll 31 11 at at IN cord-103345-v555a2ll 31 12 the the DT cord-103345-v555a2ll 31 13 plasma plasma NN cord-103345-v555a2ll 31 14 membrane membrane NN cord-103345-v555a2ll 31 15 and and CC cord-103345-v555a2ll 31 16 mitochondria mitochondrion NNS cord-103345-v555a2ll 31 17 ( ( -LRB- cord-103345-v555a2ll 31 18 4 4 CD cord-103345-v555a2ll 31 19 , , , cord-103345-v555a2ll 31 20 5 5 CD cord-103345-v555a2ll 31 21 ) ) -RRB- cord-103345-v555a2ll 31 22 . . . cord-103345-v555a2ll 32 1 The the DT cord-103345-v555a2ll 32 2 role role NN cord-103345-v555a2ll 32 3 of of IN cord-103345-v555a2ll 32 4 plasma plasma NN cord-103345-v555a2ll 32 5 membrane membrane NN cord-103345-v555a2ll 32 6 CTL1 CTL1 NNP cord-103345-v555a2ll 32 7 is be VBZ cord-103345-v555a2ll 32 8 assigned assign VBN cord-103345-v555a2ll 32 9 to to IN cord-103345-v555a2ll 32 10 Cho Cho NNP cord-103345-v555a2ll 32 11 transport transport NN cord-103345-v555a2ll 32 12 for for IN cord-103345-v555a2ll 32 13 PC pc NN cord-103345-v555a2ll 32 14 synthesis synthesis NN cord-103345-v555a2ll 32 15 , , , cord-103345-v555a2ll 32 16 but but CC cord-103345-v555a2ll 32 17 the the DT cord-103345-v555a2ll 32 18 exact exact JJ cord-103345-v555a2ll 32 19 function function NN cord-103345-v555a2ll 32 20 of of IN cord-103345-v555a2ll 32 21 the the DT cord-103345-v555a2ll 32 22 mitochondrial mitochondrial JJ cord-103345-v555a2ll 32 23 CTL1 CTL1 NNP cord-103345-v555a2ll 32 24 is be VBZ cord-103345-v555a2ll 32 25 still still RB cord-103345-v555a2ll 32 26 not not RB cord-103345-v555a2ll 32 27 clear clear JJ cord-103345-v555a2ll 32 28 . . . cord-103345-v555a2ll 33 1 In in IN cord-103345-v555a2ll 33 2 the the DT cord-103345-v555a2ll 33 3 liver liver NN cord-103345-v555a2ll 33 4 and and CC cord-103345-v555a2ll 33 5 kidney kidney NN cord-103345-v555a2ll 33 6 , , , cord-103345-v555a2ll 33 7 mitochondrial mitochondrial JJ cord-103345-v555a2ll 33 8 CTL1 CTL1 NNP cord-103345-v555a2ll 33 9 transports transport VBZ cord-103345-v555a2ll 33 10 Cho Cho NNP cord-103345-v555a2ll 33 11 for for IN cord-103345-v555a2ll 33 12 oxidation oxidation NN cord-103345-v555a2ll 33 13 to to IN cord-103345-v555a2ll 33 14 betaine betaine NN cord-103345-v555a2ll 33 15 , , , cord-103345-v555a2ll 33 16 the the DT cord-103345-v555a2ll 33 17 major major JJ cord-103345-v555a2ll 33 18 methyl methyl NN cord-103345-v555a2ll 33 19 donor donor NN cord-103345-v555a2ll 33 20 in in IN cord-103345-v555a2ll 33 21 the the DT cord-103345-v555a2ll 33 22 one one CD cord-103345-v555a2ll 33 23 - - HYPH cord-103345-v555a2ll 33 24 carbon carbon NN cord-103345-v555a2ll 33 25 cycle cycle NN cord-103345-v555a2ll 33 26 ( ( -LRB- cord-103345-v555a2ll 33 27 6 6 CD cord-103345-v555a2ll 33 28 ) ) -RRB- cord-103345-v555a2ll 33 29 . . . cord-103345-v555a2ll 34 1 In in IN cord-103345-v555a2ll 34 2 other other JJ cord-103345-v555a2ll 34 3 tissues tissue NNS cord-103345-v555a2ll 34 4 however however RB cord-103345-v555a2ll 34 5 , , , cord-103345-v555a2ll 34 6 the the DT cord-103345-v555a2ll 34 7 mitochondrial mitochondrial NN cord-103345-v555a2ll 34 8 CTL1 CTL1 NNP cord-103345-v555a2ll 34 9 probably probably RB cord-103345-v555a2ll 34 10 maintains maintain VBZ cord-103345-v555a2ll 34 11 the the DT cord-103345-v555a2ll 34 12 intracellular intracellular JJ cord-103345-v555a2ll 34 13 pools pool NNS cord-103345-v555a2ll 34 14 of of IN cord-103345-v555a2ll 34 15 Cho Cho NNP cord-103345-v555a2ll 34 16 and and CC cord-103345-v555a2ll 34 17 as as IN cord-103345-v555a2ll 34 18 a a DT cord-103345-v555a2ll 34 19 H h NN cord-103345-v555a2ll 34 20 + + CC cord-103345-v555a2ll 34 21 -antiporter -antiporter NN cord-103345-v555a2ll 34 22 and and CC cord-103345-v555a2ll 34 23 modulates modulate VBZ cord-103345-v555a2ll 34 24 the the DT cord-103345-v555a2ll 34 25 electrochemical electrochemical JJ cord-103345-v555a2ll 34 26 / / SYM cord-103345-v555a2ll 34 27 proton proton NN cord-103345-v555a2ll 34 28 gradient gradient NN cord-103345-v555a2ll 34 29 in in IN cord-103345-v555a2ll 34 30 the the DT cord-103345-v555a2ll 34 31 mitochondria mitochondrion NNS cord-103345-v555a2ll 34 32 ( ( -LRB- cord-103345-v555a2ll 34 33 7 7 CD cord-103345-v555a2ll 34 34 , , , cord-103345-v555a2ll 34 35 8) 8) NN cord-103345-v555a2ll 34 36 . . . cord-103345-v555a2ll 35 1 CTL2 CTL2 NNP cord-103345-v555a2ll 35 2 / / SYM cord-103345-v555a2ll 35 3 SLC44A2 slc44a2 NN cord-103345-v555a2ll 35 4 is be VBZ cord-103345-v555a2ll 35 5 only only RB cord-103345-v555a2ll 35 6 indirectly indirectly RB cord-103345-v555a2ll 35 7 implicated implicate VBN cord-103345-v555a2ll 35 8 in in IN cord-103345-v555a2ll 35 9 PC pc NN cord-103345-v555a2ll 35 10 synthesis synthesis NN cord-103345-v555a2ll 35 11 and and CC cord-103345-v555a2ll 35 12 its -PRON- PRP$ cord-103345-v555a2ll 35 13 exact exact JJ cord-103345-v555a2ll 35 14 function function NN cord-103345-v555a2ll 35 15 is be VBZ cord-103345-v555a2ll 35 16 not not RB cord-103345-v555a2ll 35 17 firmly firmly RB cord-103345-v555a2ll 35 18 established establish VBN cord-103345-v555a2ll 35 19 in in IN cord-103345-v555a2ll 35 20 neither neither DT cord-103345-v555a2ll 35 21 whole whole JJ cord-103345-v555a2ll 35 22 cells cell NNS cord-103345-v555a2ll 35 23 nor nor CC cord-103345-v555a2ll 35 24 mitochondria mitochondrion NNS cord-103345-v555a2ll 35 25 ( ( -LRB- cord-103345-v555a2ll 35 26 4 4 CD cord-103345-v555a2ll 35 27 ) ) -RRB- cord-103345-v555a2ll 35 28 . . . cord-103345-v555a2ll 36 1 PE PE NNP cord-103345-v555a2ll 36 2 is be VBZ cord-103345-v555a2ll 36 3 the the DT cord-103345-v555a2ll 36 4 major major JJ cord-103345-v555a2ll 36 5 inner inner JJ cord-103345-v555a2ll 36 6 membrane membrane NN cord-103345-v555a2ll 36 7 phospholipid phospholipid NN cord-103345-v555a2ll 36 8 with with IN cord-103345-v555a2ll 36 9 specific specific JJ cord-103345-v555a2ll 36 10 roles role NNS cord-103345-v555a2ll 36 11 in in IN cord-103345-v555a2ll 36 12 mitochondrial mitochondrial JJ cord-103345-v555a2ll 36 13 fusion fusion NN cord-103345-v555a2ll 36 14 , , , cord-103345-v555a2ll 36 15 autophagy autophagy NN cord-103345-v555a2ll 36 16 and and CC cord-103345-v555a2ll 36 17 apoptosis apoptosis NN cord-103345-v555a2ll 36 18 ( ( -LRB- cord-103345-v555a2ll 36 19 9 9 CD cord-103345-v555a2ll 36 20 -11 -11 CD cord-103345-v555a2ll 36 21 ) ) -RRB- cord-103345-v555a2ll 36 22 . . . cord-103345-v555a2ll 37 1 PE PE NNP cord-103345-v555a2ll 37 2 is be VBZ cord-103345-v555a2ll 37 3 also also RB cord-103345-v555a2ll 37 4 a a DT cord-103345-v555a2ll 37 5 valuable valuable JJ cord-103345-v555a2ll 37 6 source source NN cord-103345-v555a2ll 37 7 of of IN cord-103345-v555a2ll 37 8 other other JJ cord-103345-v555a2ll 37 9 phospholipids phospholipid NNS cord-103345-v555a2ll 37 10 . . . cord-103345-v555a2ll 38 1 PC pc NN cord-103345-v555a2ll 38 2 is be VBZ cord-103345-v555a2ll 38 3 produced produce VBN cord-103345-v555a2ll 38 4 by by IN cord-103345-v555a2ll 38 5 methylation methylation NN cord-103345-v555a2ll 38 6 of of IN cord-103345-v555a2ll 38 7 PE PE NNP cord-103345-v555a2ll 38 8 while while IN cord-103345-v555a2ll 38 9 phosphatidylserine phosphatidylserine NN cord-103345-v555a2ll 38 10 ( ( -LRB- cord-103345-v555a2ll 38 11 PS PS NNP cord-103345-v555a2ll 38 12 ) ) -RRB- cord-103345-v555a2ll 38 13 is be VBZ cord-103345-v555a2ll 38 14 produced produce VBN cord-103345-v555a2ll 38 15 by by IN cord-103345-v555a2ll 38 16 an an DT cord-103345-v555a2ll 38 17 exchange exchange NN cord-103345-v555a2ll 38 18 mechanism mechanism NN cord-103345-v555a2ll 38 19 whereby whereby WRB cord-103345-v555a2ll 38 20 the the DT cord-103345-v555a2ll 38 21 Etn Etn NNP cord-103345-v555a2ll 38 22 moiety moiety NN cord-103345-v555a2ll 38 23 of of IN cord-103345-v555a2ll 38 24 PE PE NNP cord-103345-v555a2ll 38 25 is be VBZ cord-103345-v555a2ll 38 26 replaced replace VBN cord-103345-v555a2ll 38 27 with with IN cord-103345-v555a2ll 38 28 serine serine NN cord-103345-v555a2ll 38 29 and and CC cord-103345-v555a2ll 38 30 free free JJ cord-103345-v555a2ll 39 1 Etn Etn NNP cord-103345-v555a2ll 39 2 is be VBZ cord-103345-v555a2ll 39 3 released release VBN cord-103345-v555a2ll 39 4 . . . cord-103345-v555a2ll 40 1 PC pc NN cord-103345-v555a2ll 40 2 could could MD cord-103345-v555a2ll 40 3 also also RB cord-103345-v555a2ll 40 4 produce produce VB cord-103345-v555a2ll 40 5 PS PS NNP cord-103345-v555a2ll 40 6 by by IN cord-103345-v555a2ll 40 7 a a DT cord-103345-v555a2ll 40 8 similar similar JJ cord-103345-v555a2ll 40 9 exchange exchange NN cord-103345-v555a2ll 40 10 mechanism mechanism NN cord-103345-v555a2ll 40 11 , , , cord-103345-v555a2ll 40 12 with with IN cord-103345-v555a2ll 40 13 free free JJ cord-103345-v555a2ll 40 14 Cho Cho NNP cord-103345-v555a2ll 40 15 being be VBG cord-103345-v555a2ll 40 16 released release VBN cord-103345-v555a2ll 40 17 . . . cord-103345-v555a2ll 41 1 The the DT cord-103345-v555a2ll 41 2 metabolically metabolically RB cord-103345-v555a2ll 41 3 released release VBN cord-103345-v555a2ll 41 4 Cho Cho NNP cord-103345-v555a2ll 41 5 and and CC cord-103345-v555a2ll 41 6 Etn Etn NNP cord-103345-v555a2ll 41 7 need need VBP cord-103345-v555a2ll 41 8 to to TO cord-103345-v555a2ll 41 9 be be VB cord-103345-v555a2ll 41 10 transported transport VBN cord-103345-v555a2ll 41 11 in in IN cord-103345-v555a2ll 41 12 and and CC cord-103345-v555a2ll 41 13 out out IN cord-103345-v555a2ll 41 14 of of IN cord-103345-v555a2ll 41 15 the the DT cord-103345-v555a2ll 41 16 cytosol cytosol NN cord-103345-v555a2ll 41 17 and and CC cord-103345-v555a2ll 41 18 mitochondria mitochondrion NNS cord-103345-v555a2ll 41 19 or or CC cord-103345-v555a2ll 41 20 reincorporated reincorporate VBD cord-103345-v555a2ll 41 21 into into IN cord-103345-v555a2ll 41 22 the the DT cord-103345-v555a2ll 41 23 Kennedy Kennedy NNP cord-103345-v555a2ll 41 24 pathway pathway NN cord-103345-v555a2ll 41 25 ( ( -LRB- cord-103345-v555a2ll 41 26 3 3 CD cord-103345-v555a2ll 41 27 -6 -6 CD cord-103345-v555a2ll 41 28 ) ) -RRB- cord-103345-v555a2ll 41 29 . . . cord-103345-v555a2ll 42 1 That that DT cord-103345-v555a2ll 42 2 mammalian mammalian NN cord-103345-v555a2ll 42 3 Etn Etn NNP cord-103345-v555a2ll 42 4 and and CC cord-103345-v555a2ll 42 5 Cho Cho NNP cord-103345-v555a2ll 42 6 transport transport NN cord-103345-v555a2ll 42 7 may may MD cord-103345-v555a2ll 42 8 occur occur VB cord-103345-v555a2ll 42 9 through through IN cord-103345-v555a2ll 42 10 a a DT cord-103345-v555a2ll 42 11 similar similar JJ cord-103345-v555a2ll 42 12 transport transport NN cord-103345-v555a2ll 42 13 system system NN cord-103345-v555a2ll 42 14 was be VBD cord-103345-v555a2ll 42 15 implicated implicate VBN cord-103345-v555a2ll 42 16 from from IN cord-103345-v555a2ll 42 17 early early JJ cord-103345-v555a2ll 42 18 kinetic kinetic JJ cord-103345-v555a2ll 42 19 studies study NNS cord-103345-v555a2ll 42 20 in in IN cord-103345-v555a2ll 42 21 bovine bovine JJ cord-103345-v555a2ll 42 22 endothelial endothelial JJ cord-103345-v555a2ll 42 23 cells cell NNS cord-103345-v555a2ll 42 24 , , , cord-103345-v555a2ll 42 25 human human JJ cord-103345-v555a2ll 42 26 retinoblastoma retinoblastoma NN cord-103345-v555a2ll 42 27 cells cell NNS cord-103345-v555a2ll 42 28 and and CC cord-103345-v555a2ll 42 29 glial glial JJ cord-103345-v555a2ll 42 30 cells cell NNS cord-103345-v555a2ll 42 31 ( ( -LRB- cord-103345-v555a2ll 42 32 12 12 CD cord-103345-v555a2ll 42 33 -14 -14 CD cord-103345-v555a2ll 42 34 ) ) -RRB- cord-103345-v555a2ll 42 35 . . . cord-103345-v555a2ll 43 1 Here here RB cord-103345-v555a2ll 43 2 , , , cord-103345-v555a2ll 43 3 we -PRON- PRP cord-103345-v555a2ll 43 4 demonstrate demonstrate VBP cord-103345-v555a2ll 43 5 that that IN cord-103345-v555a2ll 43 6 CTL1 CTL1 NNP cord-103345-v555a2ll 43 7 / / SYM cord-103345-v555a2ll 43 8 SLC44A1 slc44a1 NN cord-103345-v555a2ll 43 9 and and CC cord-103345-v555a2ll 43 10 CTL2 CTL2 NNP cord-103345-v555a2ll 43 11 / / SYM cord-103345-v555a2ll 43 12 SLC44A2 SLC44A2 NNS cord-103345-v555a2ll 43 13 are be VBP cord-103345-v555a2ll 43 14 authentic authentic JJ cord-103345-v555a2ll 44 1 Etn etn IN cord-103345-v555a2ll 44 2 transporters transporter NNS cord-103345-v555a2ll 44 3 at at IN cord-103345-v555a2ll 44 4 the the DT cord-103345-v555a2ll 44 5 cell cell NN cord-103345-v555a2ll 44 6 surface surface NN cord-103345-v555a2ll 44 7 and and CC cord-103345-v555a2ll 44 8 mitochondria mitochondrion NNS cord-103345-v555a2ll 44 9 . . . cord-103345-v555a2ll 45 1 We -PRON- PRP cord-103345-v555a2ll 45 2 examine examine VBP cord-103345-v555a2ll 45 3 the the DT cord-103345-v555a2ll 45 4 kinetics kinetic NNS cord-103345-v555a2ll 45 5 of of IN cord-103345-v555a2ll 45 6 Etn Etn NNP cord-103345-v555a2ll 45 7 transport transport NN cord-103345-v555a2ll 45 8 in in IN cord-103345-v555a2ll 45 9 CTL1 CTL1 NNP cord-103345-v555a2ll 45 10 and and CC cord-103345-v555a2ll 45 11 CTL2 CTL2 NNP cord-103345-v555a2ll 45 12 depleted depleted JJ cord-103345-v555a2ll 45 13 conditions condition NNS cord-103345-v555a2ll 45 14 and and CC cord-103345-v555a2ll 45 15 overexpressing overexpressing NN cord-103345-v555a2ll 45 16 cells cell NNS cord-103345-v555a2ll 45 17 . . . cord-103345-v555a2ll 46 1 We -PRON- PRP cord-103345-v555a2ll 46 2 characterize characterize VBP cord-103345-v555a2ll 46 3 Etn etn PRP$ cord-103345-v555a2ll 46 4 transport transport NN cord-103345-v555a2ll 46 5 in in IN cord-103345-v555a2ll 46 6 human human JJ cord-103345-v555a2ll 46 7 skin skin NN cord-103345-v555a2ll 46 8 fibroblasts fibroblast NNS cord-103345-v555a2ll 46 9 that that WDT cord-103345-v555a2ll 46 10 maintain maintain VBP cord-103345-v555a2ll 46 11 CTL2 CTL2 NNP cord-103345-v555a2ll 46 12 but but CC cord-103345-v555a2ll 46 13 lack lack VB cord-103345-v555a2ll 46 14 CTL1 ctl1 JJ cord-103345-v555a2ll 46 15 function function NN cord-103345-v555a2ll 46 16 due due IN cord-103345-v555a2ll 46 17 to to IN cord-103345-v555a2ll 46 18 inherited inherit VBN cord-103345-v555a2ll 46 19 CTL1 CTL1 NNP cord-103345-v555a2ll 46 20 / / SYM cord-103345-v555a2ll 46 21 SLC44A1 slc44a1 NN cord-103345-v555a2ll 46 22 frameshift frameshift NN cord-103345-v555a2ll 46 23 mutations mutation NNS cord-103345-v555a2ll 46 24 ( ( -LRB- cord-103345-v555a2ll 46 25 M1= M1= NNP cord-103345-v555a2ll 46 26 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 46 27 ΔAsp517 ΔAsp517 NNP cord-103345-v555a2ll 46 28 and and CC cord-103345-v555a2ll 46 29 M2= M2= NNP cord-103345-v555a2ll 46 30 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 46 31 ΔSer126 δser126 NN cord-103345-v555a2ll 46 32 ) ) -RRB- cord-103345-v555a2ll 46 33 ( ( -LRB- cord-103345-v555a2ll 46 34 15 15 CD cord-103345-v555a2ll 46 35 ) ) -RRB- cord-103345-v555a2ll 46 36 . . . cord-103345-v555a2ll 47 1 We -PRON- PRP cord-103345-v555a2ll 47 2 employ employ VBP cord-103345-v555a2ll 47 3 pharmacological pharmacological JJ cord-103345-v555a2ll 47 4 and and CC cord-103345-v555a2ll 47 5 antibody antibody NN cord-103345-v555a2ll 47 6 induced induce VBN cord-103345-v555a2ll 47 7 inhibition inhibition NN cord-103345-v555a2ll 47 8 to to TO cord-103345-v555a2ll 47 9 separate separate VB cord-103345-v555a2ll 47 10 the the DT cord-103345-v555a2ll 47 11 contributions contribution NNS cord-103345-v555a2ll 47 12 of of IN cord-103345-v555a2ll 47 13 the the DT cord-103345-v555a2ll 47 14 CTL1 CTL1 NNP cord-103345-v555a2ll 47 15 and and CC cord-103345-v555a2ll 47 16 CTL2 CTL2 NNP cord-103345-v555a2ll 47 17 to to TO cord-103345-v555a2ll 47 18 Etn etn CC cord-103345-v555a2ll 47 19 transport transport VB cord-103345-v555a2ll 47 20 and and CC cord-103345-v555a2ll 47 21 PE pe NN cord-103345-v555a2ll 47 22 synthesis synthesis NN cord-103345-v555a2ll 47 23 . . . cord-103345-v555a2ll 48 1 This this DT cord-103345-v555a2ll 48 2 study study NN cord-103345-v555a2ll 48 3 is be VBZ cord-103345-v555a2ll 48 4 the the DT cord-103345-v555a2ll 48 5 first first JJ cord-103345-v555a2ll 48 6 to to TO cord-103345-v555a2ll 48 7 demonstrate demonstrate VB cord-103345-v555a2ll 48 8 that that IN cord-103345-v555a2ll 48 9 the the DT cord-103345-v555a2ll 48 10 CTL1 CTL1 NNP cord-103345-v555a2ll 48 11 and and CC cord-103345-v555a2ll 48 12 CTL2 CTL2 NNP cord-103345-v555a2ll 48 13 are be VBP cord-103345-v555a2ll 48 14 high high JJ cord-103345-v555a2ll 48 15 and and CC cord-103345-v555a2ll 48 16 low low JJ cord-103345-v555a2ll 48 17 to to IN cord-103345-v555a2ll 48 18 medium medium JJ cord-103345-v555a2ll 48 19 affinity affinity NN cord-103345-v555a2ll 48 20 cellular cellular JJ cord-103345-v555a2ll 48 21 and and CC cord-103345-v555a2ll 48 22 mitochondrial mitochondrial NN cord-103345-v555a2ll 49 1 Etn etn IN cord-103345-v555a2ll 49 2 transporters transporter NNS cord-103345-v555a2ll 49 3 . . . cord-103345-v555a2ll 50 1 To to IN cord-103345-v555a2ll 50 2 our -PRON- PRP$ cord-103345-v555a2ll 50 3 knowledge knowledge NN cord-103345-v555a2ll 50 4 , , , cord-103345-v555a2ll 50 5 this this DT cord-103345-v555a2ll 50 6 is be VBZ cord-103345-v555a2ll 50 7 the the DT cord-103345-v555a2ll 50 8 first first JJ cord-103345-v555a2ll 50 9 study study NN cord-103345-v555a2ll 50 10 to to TO cord-103345-v555a2ll 50 11 demonstrate demonstrate VB cord-103345-v555a2ll 50 12 that that IN cord-103345-v555a2ll 50 13 as as RB cord-103345-v555a2ll 50 14 intrinsic intrinsic JJ cord-103345-v555a2ll 50 15 Etn Etn NNP cord-103345-v555a2ll 50 16 transporters transporter NNS cord-103345-v555a2ll 50 17 , , , cord-103345-v555a2ll 50 18 CTL1 CTL1 NNP cord-103345-v555a2ll 50 19 and and CC cord-103345-v555a2ll 50 20 CTL2 CTL2 NNP cord-103345-v555a2ll 50 21 regulate regulate VBP cord-103345-v555a2ll 50 22 the the DT cord-103345-v555a2ll 50 23 supply supply NN cord-103345-v555a2ll 50 24 of of IN cord-103345-v555a2ll 50 25 extracellular extracellular JJ cord-103345-v555a2ll 50 26 Etn Etn NNP cord-103345-v555a2ll 50 27 for for IN cord-103345-v555a2ll 50 28 the the DT cord-103345-v555a2ll 50 29 CDP CDP NNP cord-103345-v555a2ll 50 30 - - HYPH cord-103345-v555a2ll 50 31 Etn Etn NNP cord-103345-v555a2ll 50 32 pathway pathway NN cord-103345-v555a2ll 50 33 , , , cord-103345-v555a2ll 50 34 redistribute redistribute VB cord-103345-v555a2ll 50 35 intracellular intracellular JJ cord-103345-v555a2ll 50 36 Etn Etn NNP cord-103345-v555a2ll 50 37 and and CC cord-103345-v555a2ll 50 38 balance balance VB cord-103345-v555a2ll 50 39 CDP CDP NNP cord-103345-v555a2ll 50 40 - - HYPH cord-103345-v555a2ll 50 41 Cho Cho NNP cord-103345-v555a2ll 50 42 and and CC cord-103345-v555a2ll 50 43 CDP CDP NNP cord-103345-v555a2ll 50 44 - - HYPH cord-103345-v555a2ll 50 45 Etn Etn NNP cord-103345-v555a2ll 50 46 arms arm NNS cord-103345-v555a2ll 50 47 of of IN cord-103345-v555a2ll 50 48 the the DT cord-103345-v555a2ll 50 49 Kennedy Kennedy NNP cord-103345-v555a2ll 50 50 pathway pathway NN cord-103345-v555a2ll 50 51 . . . cord-103345-v555a2ll 51 1 To to TO cord-103345-v555a2ll 51 2 assess assess VB cord-103345-v555a2ll 51 3 the the DT cord-103345-v555a2ll 51 4 magnitude magnitude NN cord-103345-v555a2ll 51 5 by by IN cord-103345-v555a2ll 51 6 which which WDT cord-103345-v555a2ll 51 7 CTL1/2 CTL1/2 . cord-103345-v555a2ll 52 1 inhibition inhibition NN cord-103345-v555a2ll 52 2 affects affect VBZ cord-103345-v555a2ll 52 3 PE PE NNP cord-103345-v555a2ll 52 4 and and CC cord-103345-v555a2ll 52 5 PC pc NN cord-103345-v555a2ll 52 6 levels level NNS cord-103345-v555a2ll 52 7 , , , cord-103345-v555a2ll 52 8 two two CD cord-103345-v555a2ll 52 9 types type NNS cord-103345-v555a2ll 52 10 of of IN cord-103345-v555a2ll 52 11 cells cell NNS cord-103345-v555a2ll 52 12 were be VBD cord-103345-v555a2ll 52 13 characterized characterize VBN cord-103345-v555a2ll 52 14 for for IN cord-103345-v555a2ll 52 15 phospholipid phospholipid NN cord-103345-v555a2ll 52 16 metabolism metabolism NN cord-103345-v555a2ll 52 17 ( ( -LRB- cord-103345-v555a2ll 52 18 MCF-7 MCF-7 NNP cord-103345-v555a2ll 52 19 and and CC cord-103345-v555a2ll 52 20 MCF-10 MCF-10 NNP cord-103345-v555a2ll 52 21 ) ) -RRB- cord-103345-v555a2ll 52 22 ( ( -LRB- cord-103345-v555a2ll 52 23 16 16 CD cord-103345-v555a2ll 52 24 , , , cord-103345-v555a2ll 52 25 17 17 CD cord-103345-v555a2ll 52 26 ) ) -RRB- cord-103345-v555a2ll 52 27 . . . cord-103345-v555a2ll 53 1 The the DT cord-103345-v555a2ll 53 2 cells cell NNS cord-103345-v555a2ll 53 3 were be VBD cord-103345-v555a2ll 53 4 treated treat VBN cord-103345-v555a2ll 53 5 for for IN cord-103345-v555a2ll 53 6 24h 24h NNS cord-103345-v555a2ll 53 7 with with IN cord-103345-v555a2ll 53 8 [ [ -LRB- cord-103345-v555a2ll 53 9 3 3 CD cord-103345-v555a2ll 53 10 H]-glycerol H]-glycerol NNP cord-103345-v555a2ll 53 11 , , , cord-103345-v555a2ll 53 12 to to TO cord-103345-v555a2ll 53 13 label label VB cord-103345-v555a2ll 53 14 the the DT cord-103345-v555a2ll 53 15 entire entire JJ cord-103345-v555a2ll 53 16 glycerolipid glycerolipid NNP cord-103345-v555a2ll 53 17 pools pool NNS cord-103345-v555a2ll 53 18 ( ( -LRB- cord-103345-v555a2ll 53 19 steady steady JJ cord-103345-v555a2ll 53 20 - - HYPH cord-103345-v555a2ll 53 21 state state NN cord-103345-v555a2ll 53 22 levels level NNS cord-103345-v555a2ll 53 23 ) ) -RRB- cord-103345-v555a2ll 53 24 in in IN cord-103345-v555a2ll 53 25 the the DT cord-103345-v555a2ll 53 26 presence presence NN cord-103345-v555a2ll 53 27 and and CC cord-103345-v555a2ll 53 28 absence absence NN cord-103345-v555a2ll 53 29 of of IN cord-103345-v555a2ll 53 30 CTL1 ctl1 JJ cord-103345-v555a2ll 53 31 transport transport NN cord-103345-v555a2ll 53 32 inhibitor inhibitor NN cord-103345-v555a2ll 53 33 hemicholinium-3 hemicholinium-3 NNP cord-103345-v555a2ll 53 34 ( ( -LRB- cord-103345-v555a2ll 53 35 HC-3 HC-3 NNP cord-103345-v555a2ll 53 36 ) ) -RRB- cord-103345-v555a2ll 53 37 or or CC cord-103345-v555a2ll 53 38 CTL1 ctl1 JJ cord-103345-v555a2ll 53 39 specific specific JJ cord-103345-v555a2ll 53 40 antibody antibody NN cord-103345-v555a2ll 53 41 ( ( -LRB- cord-103345-v555a2ll 53 42 Fig Fig NNP cord-103345-v555a2ll 53 43 . . . cord-103345-v555a2ll 53 44 1A 1a NN cord-103345-v555a2ll 53 45 and and CC cord-103345-v555a2ll 53 46 B B NNP cord-103345-v555a2ll 53 47 ) ) -RRB- cord-103345-v555a2ll 53 48 . . . cord-103345-v555a2ll 54 1 Surprisingly surprisingly RB cord-103345-v555a2ll 54 2 , , , cord-103345-v555a2ll 54 3 HC-3 HC-3 NNP cord-103345-v555a2ll 54 4 reduced reduce VBD cord-103345-v555a2ll 54 5 the the DT cord-103345-v555a2ll 54 6 steady steady JJ cord-103345-v555a2ll 54 7 - - HYPH cord-103345-v555a2ll 54 8 state state NN cord-103345-v555a2ll 54 9 levels level NNS cord-103345-v555a2ll 54 10 not not RB cord-103345-v555a2ll 54 11 only only RB cord-103345-v555a2ll 54 12 of of IN cord-103345-v555a2ll 54 13 PC pc NN cord-103345-v555a2ll 54 14 ( ( -LRB- cord-103345-v555a2ll 54 15 25 25 CD cord-103345-v555a2ll 54 16 - - SYM cord-103345-v555a2ll 54 17 50 50 CD cord-103345-v555a2ll 54 18 % % NN cord-103345-v555a2ll 54 19 ) ) -RRB- cord-103345-v555a2ll 54 20 but but CC cord-103345-v555a2ll 54 21 also also RB cord-103345-v555a2ll 54 22 of of IN cord-103345-v555a2ll 54 23 PE PE NNP cord-103345-v555a2ll 54 24 ( ( -LRB- cord-103345-v555a2ll 54 25 50 50 CD cord-103345-v555a2ll 54 26 % % NN cord-103345-v555a2ll 54 27 ) ) -RRB- cord-103345-v555a2ll 54 28 in in IN cord-103345-v555a2ll 54 29 both both DT cord-103345-v555a2ll 54 30 cell cell NN cord-103345-v555a2ll 54 31 types type NNS cord-103345-v555a2ll 54 32 . . . cord-103345-v555a2ll 55 1 CTL1 ctl1 JJ cord-103345-v555a2ll 55 2 antibody antibody NN cord-103345-v555a2ll 55 3 similarly similarly RB cord-103345-v555a2ll 55 4 reduced reduce VBN cord-103345-v555a2ll 55 5 PC pc NN cord-103345-v555a2ll 55 6 and and CC cord-103345-v555a2ll 55 7 PE PE NNP cord-103345-v555a2ll 55 8 levels level NNS cord-103345-v555a2ll 55 9 ( ( -LRB- cord-103345-v555a2ll 55 10 40 40 CD cord-103345-v555a2ll 55 11 - - SYM cord-103345-v555a2ll 55 12 50 50 CD cord-103345-v555a2ll 55 13 % % NN cord-103345-v555a2ll 55 14 ) ) -RRB- cord-103345-v555a2ll 55 15 , , , cord-103345-v555a2ll 55 16 further further RB cord-103345-v555a2ll 55 17 indicating indicate VBG cord-103345-v555a2ll 55 18 that that IN cord-103345-v555a2ll 55 19 CTL1 CTL1 NNP cord-103345-v555a2ll 55 20 could could MD cord-103345-v555a2ll 55 21 be be VB cord-103345-v555a2ll 55 22 involved involve VBN cord-103345-v555a2ll 55 23 in in IN cord-103345-v555a2ll 55 24 the the DT cord-103345-v555a2ll 55 25 transport transport NN cord-103345-v555a2ll 55 26 of of IN cord-103345-v555a2ll 55 27 Etn Etn NNP cord-103345-v555a2ll 55 28 , , , cord-103345-v555a2ll 55 29 in in IN cord-103345-v555a2ll 55 30 addition addition NN cord-103345-v555a2ll 55 31 to to IN cord-103345-v555a2ll 55 32 its -PRON- PRP$ cord-103345-v555a2ll 55 33 well well RB cord-103345-v555a2ll 55 34 - - HYPH cord-103345-v555a2ll 55 35 characterized characterize VBN cord-103345-v555a2ll 55 36 function function NN cord-103345-v555a2ll 55 37 in in IN cord-103345-v555a2ll 55 38 Cho Cho NNP cord-103345-v555a2ll 55 39 transport transport NN cord-103345-v555a2ll 55 40 ( ( -LRB- cord-103345-v555a2ll 55 41 15 15 CD cord-103345-v555a2ll 55 42 , , , cord-103345-v555a2ll 55 43 18 18 CD cord-103345-v555a2ll 55 44 ) ) -RRB- cord-103345-v555a2ll 55 45 . . . cord-103345-v555a2ll 56 1 µM µm UH cord-103345-v555a2ll 56 2 , , , cord-103345-v555a2ll 56 3 Etn etn UH cord-103345-v555a2ll 56 4 , , , cord-103345-v555a2ll 56 5 Cho Cho NNP cord-103345-v555a2ll 56 6 and and CC cord-103345-v555a2ll 56 7 Etn Etn NNP cord-103345-v555a2ll 56 8 + + CC cord-103345-v555a2ll 56 9 Cho Cho NNP cord-103345-v555a2ll 56 10 were be VBD cord-103345-v555a2ll 56 11 applied apply VBN cord-103345-v555a2ll 56 12 respectively respectively RB cord-103345-v555a2ll 56 13 ( ( -LRB- cord-103345-v555a2ll 56 14 Fig Fig NNP cord-103345-v555a2ll 56 15 . . . cord-103345-v555a2ll 56 16 1D 1d CD cord-103345-v555a2ll 56 17 ) ) -RRB- cord-103345-v555a2ll 56 18 . . . cord-103345-v555a2ll 57 1 Furthermore furthermore RB cord-103345-v555a2ll 57 2 , , , cord-103345-v555a2ll 57 3 CTL1 CTL1 NNP cord-103345-v555a2ll 57 4 antibody antibody NN cord-103345-v555a2ll 57 5 inhibited inhibit VBD cord-103345-v555a2ll 57 6 14 14 CD cord-103345-v555a2ll 57 7 C C NNP cord-103345-v555a2ll 57 8 - - HYPH cord-103345-v555a2ll 57 9 Etn Etn NNP cord-103345-v555a2ll 57 10 transport transport NN cord-103345-v555a2ll 57 11 in in IN cord-103345-v555a2ll 57 12 a a DT cord-103345-v555a2ll 57 13 concentration concentration NN cord-103345-v555a2ll 57 14 - - HYPH cord-103345-v555a2ll 57 15 dependent dependent JJ cord-103345-v555a2ll 57 16 manner manner NN cord-103345-v555a2ll 57 17 with with IN cord-103345-v555a2ll 57 18 an an DT cord-103345-v555a2ll 57 19 IC50 IC50 NNP cord-103345-v555a2ll 57 20 of of IN cord-103345-v555a2ll 57 21 50 50 CD cord-103345-v555a2ll 57 22 ng ng NN cord-103345-v555a2ll 57 23 ( ( -LRB- cord-103345-v555a2ll 57 24 Fig Fig NNP cord-103345-v555a2ll 57 25 . . . cord-103345-v555a2ll 57 26 1E 1E NNP cord-103345-v555a2ll 57 27 ) ) -RRB- cord-103345-v555a2ll 57 28 . . . cord-103345-v555a2ll 58 1 CTL2 CTL2 NNP cord-103345-v555a2ll 58 2 antibody antibody NN cord-103345-v555a2ll 58 3 also also RB cord-103345-v555a2ll 58 4 inhibited inhibit VBD cord-103345-v555a2ll 58 5 both both DT cord-103345-v555a2ll 58 6 , , , cord-103345-v555a2ll 58 7 14 14 CD cord-103345-v555a2ll 58 8 C C NNP cord-103345-v555a2ll 58 9 - - HYPH cord-103345-v555a2ll 58 10 Etn Etn NNP cord-103345-v555a2ll 58 11 and and CC cord-103345-v555a2ll 58 12 3 3 CD cord-103345-v555a2ll 58 13 H H NNP cord-103345-v555a2ll 58 14 - - HYPH cord-103345-v555a2ll 58 15 Cho Cho NNP cord-103345-v555a2ll 58 16 transports transport VBZ cord-103345-v555a2ll 58 17 in in IN cord-103345-v555a2ll 58 18 a a DT cord-103345-v555a2ll 58 19 concentration concentration NN cord-103345-v555a2ll 58 20 dependent dependent JJ cord-103345-v555a2ll 58 21 manner manner NN cord-103345-v555a2ll 58 22 with with IN cord-103345-v555a2ll 58 23 LC50 LC50 NNP cord-103345-v555a2ll 58 24 50 50 CD cord-103345-v555a2ll 58 25 ng ng NNP cord-103345-v555a2ll 58 26 ( ( -LRB- cord-103345-v555a2ll 58 27 Fig Fig NNP cord-103345-v555a2ll 58 28 . . . cord-103345-v555a2ll 58 29 1F 1F NNP cord-103345-v555a2ll 58 30 , , , cord-103345-v555a2ll 58 31 G G NNP cord-103345-v555a2ll 58 32 ) ) -RRB- cord-103345-v555a2ll 58 33 . . . cord-103345-v555a2ll 59 1 Together together RB cord-103345-v555a2ll 59 2 , , , cord-103345-v555a2ll 59 3 the the DT cord-103345-v555a2ll 59 4 data datum NNS cord-103345-v555a2ll 59 5 showed show VBD cord-103345-v555a2ll 59 6 that that IN cord-103345-v555a2ll 59 7 Etn Etn NNP cord-103345-v555a2ll 59 8 is be VBZ cord-103345-v555a2ll 59 9 a a DT cord-103345-v555a2ll 59 10 3ubstrate 3ubstrate NN cord-103345-v555a2ll 59 11 for for IN cord-103345-v555a2ll 59 12 CTL1 CTL1 NNP cord-103345-v555a2ll 59 13 and and CC cord-103345-v555a2ll 59 14 CTL2-mediated ctl2-mediated JJ cord-103345-v555a2ll 59 15 transports transport NNS cord-103345-v555a2ll 59 16 , , , cord-103345-v555a2ll 59 17 in in IN cord-103345-v555a2ll 59 18 addition addition NN cord-103345-v555a2ll 59 19 to to TO cord-103345-v555a2ll 59 20 already already RB cord-103345-v555a2ll 59 21 establish establish VB cord-103345-v555a2ll 59 22 functions function NNS cord-103345-v555a2ll 59 23 in in IN cord-103345-v555a2ll 59 24 Cho Cho NNP cord-103345-v555a2ll 59 25 transport transport NN cord-103345-v555a2ll 59 26 . . . cord-103345-v555a2ll 60 1 We -PRON- PRP cord-103345-v555a2ll 60 2 studied study VBD cord-103345-v555a2ll 60 3 the the DT cord-103345-v555a2ll 60 4 kinetics kinetic NNS cord-103345-v555a2ll 60 5 of of IN cord-103345-v555a2ll 60 6 Etn Etn NNP cord-103345-v555a2ll 60 7 transport transport NN cord-103345-v555a2ll 60 8 in in IN cord-103345-v555a2ll 60 9 monkey monkey NN cord-103345-v555a2ll 60 10 COS-7 cos-7 NN cord-103345-v555a2ll 60 11 cells cell NNS cord-103345-v555a2ll 60 12 and and CC cord-103345-v555a2ll 60 13 control control NN cord-103345-v555a2ll 60 14 ( ( -LRB- cord-103345-v555a2ll 60 15 Ctrl ctrl NN cord-103345-v555a2ll 60 16 ) ) -RRB- cord-103345-v555a2ll 60 17 and and CC cord-103345-v555a2ll 60 18 CTL1 ctl1 JJ cord-103345-v555a2ll 60 19 deficient deficient JJ cord-103345-v555a2ll 60 20 ( ( -LRB- cord-103345-v555a2ll 60 21 M1 M1 NNP cord-103345-v555a2ll 60 22 = = SYM cord-103345-v555a2ll 60 23 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 60 24 ΔAsp517 ΔAsp517 NNS cord-103345-v555a2ll 60 25 and and CC cord-103345-v555a2ll 60 26 M2= M2= NNS cord-103345-v555a2ll 61 1 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 61 2 Ser126 ser126 CD cord-103345-v555a2ll 61 3 ) ) -RRB- cord-103345-v555a2ll 62 1 primary primary JJ cord-103345-v555a2ll 62 2 human human JJ cord-103345-v555a2ll 62 3 fibroblasts fibroblast NNS cord-103345-v555a2ll 62 4 . . . cord-103345-v555a2ll 63 1 As as IN cord-103345-v555a2ll 63 2 expected expect VBN cord-103345-v555a2ll 63 3 , , , cord-103345-v555a2ll 63 4 COS-7 cos-7 NN cord-103345-v555a2ll 63 5 cells cell NNS cord-103345-v555a2ll 63 6 and and CC cord-103345-v555a2ll 63 7 Ctrl ctrl NN cord-103345-v555a2ll 63 8 fibroblasts fibroblast NNS cord-103345-v555a2ll 63 9 expressed express VBD cord-103345-v555a2ll 63 10 CTL1 CTL1 NNP cord-103345-v555a2ll 63 11 and and CC cord-103345-v555a2ll 63 12 CTL2 CTL2 NNP cord-103345-v555a2ll 63 13 proteins protein NNS cord-103345-v555a2ll 63 14 while while IN cord-103345-v555a2ll 63 15 CTL1 ctl1 JJ cord-103345-v555a2ll 63 16 mutant mutant JJ cord-103345-v555a2ll 63 17 fibroblasts fibroblast NNS cord-103345-v555a2ll 63 18 M1 M1 NNP cord-103345-v555a2ll 63 19 and and CC cord-103345-v555a2ll 63 20 M2 M2 NNP cord-103345-v555a2ll 63 21 only only RB cord-103345-v555a2ll 63 22 expressed express VBD cord-103345-v555a2ll 63 23 CTL2 CTL2 NNP cord-103345-v555a2ll 63 24 protein protein NN cord-103345-v555a2ll 63 25 ( ( -LRB- cord-103345-v555a2ll 63 26 Fig Fig NNP cord-103345-v555a2ll 63 27 . . . cord-103345-v555a2ll 63 28 2A 2a CD cord-103345-v555a2ll 63 29 ) ) -RRB- cord-103345-v555a2ll 63 30 . . . cord-103345-v555a2ll 64 1 14 14 CD cord-103345-v555a2ll 64 2 C C NNP cord-103345-v555a2ll 64 3 - - HYPH cord-103345-v555a2ll 64 4 Etn etn JJ cord-103345-v555a2ll 64 5 transport transport NN cord-103345-v555a2ll 64 6 rates rate NNS cord-103345-v555a2ll 64 7 ( ( -LRB- cord-103345-v555a2ll 64 8 V v NN cord-103345-v555a2ll 64 9 ) ) -RRB- cord-103345-v555a2ll 64 10 plotted plot VBN cord-103345-v555a2ll 64 11 against against IN cord-103345-v555a2ll 64 12 [ [ -LRB- cord-103345-v555a2ll 64 13 Etn etn RB cord-103345-v555a2ll 64 14 ] ] -RRB- cord-103345-v555a2ll 64 15 produced produce VBD cord-103345-v555a2ll 64 16 a a DT cord-103345-v555a2ll 64 17 series series NN cord-103345-v555a2ll 64 18 of of IN cord-103345-v555a2ll 64 19 saturation saturation NN cord-103345-v555a2ll 64 20 curves curve NNS cord-103345-v555a2ll 64 21 , , , cord-103345-v555a2ll 64 22 as as IN cord-103345-v555a2ll 64 23 expected expect VBN cord-103345-v555a2ll 64 24 for for IN cord-103345-v555a2ll 64 25 protein protein NN cord-103345-v555a2ll 64 26 mediated mediate VBN cord-103345-v555a2ll 64 27 transports transport NNS cord-103345-v555a2ll 64 28 ( ( -LRB- cord-103345-v555a2ll 64 29 Fig Fig NNP cord-103345-v555a2ll 64 30 . . . cord-103345-v555a2ll 64 31 2B 2b CD cord-103345-v555a2ll 64 32 ) ) -RRB- cord-103345-v555a2ll 64 33 . . . cord-103345-v555a2ll 65 1 Vmax Vmax NNP cord-103345-v555a2ll 65 2 values value NNS cord-103345-v555a2ll 65 3 were be VBD cord-103345-v555a2ll 65 4 nearly nearly RB cord-103345-v555a2ll 65 5 identical identical JJ cord-103345-v555a2ll 65 6 in in IN cord-103345-v555a2ll 65 7 Ctrl ctrl NN cord-103345-v555a2ll 65 8 and and CC cord-103345-v555a2ll 65 9 COS-7 COS-7 NNP cord-103345-v555a2ll 65 10 cells cell NNS cord-103345-v555a2ll 66 1 ( ( -LRB- cord-103345-v555a2ll 66 2 Vmax Vmax NNP cord-103345-v555a2ll 66 3 = = SYM cord-103345-v555a2ll 66 4 26.9 26.9 CD cord-103345-v555a2ll 66 5 and and CC cord-103345-v555a2ll 66 6 26.3 26.3 CD cord-103345-v555a2ll 66 7 nmol nmol NNP cord-103345-v555a2ll 66 8 / / SYM cord-103345-v555a2ll 66 9 mg mg NNP cord-103345-v555a2ll 66 10 protein protein NNP cord-103345-v555a2ll 66 11 / / SYM cord-103345-v555a2ll 66 12 min min NNP cord-103345-v555a2ll 66 13 ) ) -RRB- cord-103345-v555a2ll 66 14 and and CC cord-103345-v555a2ll 66 15 M1 M1 NNP cord-103345-v555a2ll 66 16 and and CC cord-103345-v555a2ll 66 17 M2 M2 NNP cord-103345-v555a2ll 66 18 cells cell NNS cord-103345-v555a2ll 66 19 had have VBD cord-103345-v555a2ll 66 20 reduced reduce VBN cord-103345-v555a2ll 66 21 but but CC cord-103345-v555a2ll 66 22 similar similar JJ cord-103345-v555a2ll 66 23 Vmax Vmax NNP cord-103345-v555a2ll 66 24 = = SYM cord-103345-v555a2ll 66 25 20.6 20.6 CD cord-103345-v555a2ll 66 26 -21.2 -21.2 CD cord-103345-v555a2ll 66 27 nmol nmol JJ cord-103345-v555a2ll 66 28 / / SYM cord-103345-v555a2ll 66 29 mg mg NNP cord-103345-v555a2ll 66 30 protein protein NNP cord-103345-v555a2ll 66 31 / / SYM cord-103345-v555a2ll 66 32 min min NNP cord-103345-v555a2ll 67 1 ( ( -LRB- cord-103345-v555a2ll 67 2 Fig Fig NNP cord-103345-v555a2ll 67 3 . . . cord-103345-v555a2ll 67 4 2B 2B NNP cord-103345-v555a2ll 67 5 ) ) -RRB- cord-103345-v555a2ll 67 6 , , , cord-103345-v555a2ll 67 7 apparently apparently RB cord-103345-v555a2ll 67 8 caused cause VBN cord-103345-v555a2ll 67 9 by by IN cord-103345-v555a2ll 67 10 the the DT cord-103345-v555a2ll 67 11 absence absence NN cord-103345-v555a2ll 67 12 of of IN cord-103345-v555a2ll 67 13 the the DT cord-103345-v555a2ll 67 14 CTL1 ctl1 JJ cord-103345-v555a2ll 67 15 transport transport NN cord-103345-v555a2ll 67 16 component component NN cord-103345-v555a2ll 67 17 . . . cord-103345-v555a2ll 68 1 Indeed indeed RB cord-103345-v555a2ll 68 2 , , , cord-103345-v555a2ll 68 3 the the DT cord-103345-v555a2ll 68 4 Eadie Eadie NNP cord-103345-v555a2ll 68 5 - - HYPH cord-103345-v555a2ll 68 6 Hofstee Hofstee NNP cord-103345-v555a2ll 68 7 plots plot NNS cord-103345-v555a2ll 68 8 derived derive VBN cord-103345-v555a2ll 68 9 from from IN cord-103345-v555a2ll 68 10 the the DT cord-103345-v555a2ll 68 11 saturation saturation NN cord-103345-v555a2ll 68 12 curves curve NNS cord-103345-v555a2ll 68 13 were be VBD cord-103345-v555a2ll 68 14 biphasic biphasic JJ cord-103345-v555a2ll 68 15 in in IN cord-103345-v555a2ll 68 16 Ctrl ctrl NN cord-103345-v555a2ll 68 17 fibroblasts fibroblast NNS cord-103345-v555a2ll 68 18 and and CC cord-103345-v555a2ll 68 19 COS-7 cos-7 NN cord-103345-v555a2ll 68 20 cells cell NNS cord-103345-v555a2ll 68 21 and and CC cord-103345-v555a2ll 68 22 linear linear JJ cord-103345-v555a2ll 68 23 for for IN cord-103345-v555a2ll 68 24 M1 M1 NNP cord-103345-v555a2ll 68 25 and and CC cord-103345-v555a2ll 68 26 M2 M2 NNP cord-103345-v555a2ll 68 27 cells cell NNS cord-103345-v555a2ll 68 28 ( ( -LRB- cord-103345-v555a2ll 68 29 Fig Fig NNP cord-103345-v555a2ll 68 30 . . . cord-103345-v555a2ll 68 31 2C 2C NNP cord-103345-v555a2ll 68 32 ) ) -RRB- cord-103345-v555a2ll 68 33 . . . cord-103345-v555a2ll 69 1 This this DT cord-103345-v555a2ll 69 2 type type NN cord-103345-v555a2ll 69 3 of of IN cord-103345-v555a2ll 69 4 behavior behavior NN cord-103345-v555a2ll 69 5 indicated indicate VBD cord-103345-v555a2ll 69 6 the the DT cord-103345-v555a2ll 69 7 presence presence NN cord-103345-v555a2ll 69 8 of of IN cord-103345-v555a2ll 69 9 two two CD cord-103345-v555a2ll 69 10 distinct distinct JJ cord-103345-v555a2ll 69 11 transport transport NN cord-103345-v555a2ll 69 12 systems system NNS cord-103345-v555a2ll 69 13 in in IN cord-103345-v555a2ll 69 14 Ctrl ctrl NN cord-103345-v555a2ll 69 15 and and CC cord-103345-v555a2ll 69 16 COS-7 COS-7 NNP cord-103345-v555a2ll 69 17 cells cell NNS cord-103345-v555a2ll 69 18 with with IN cord-103345-v555a2ll 69 19 two two CD cord-103345-v555a2ll 69 20 binding bind VBG cord-103345-v555a2ll 69 21 constants constant NNS cord-103345-v555a2ll 69 22 , , , cord-103345-v555a2ll 69 23 of of IN cord-103345-v555a2ll 69 24 high high JJ cord-103345-v555a2ll 69 25 and and CC cord-103345-v555a2ll 69 26 low low JJ cord-103345-v555a2ll 69 27 affinity affinity NN cord-103345-v555a2ll 69 28 for for IN cord-103345-v555a2ll 69 29 Etn Etn NNP cord-103345-v555a2ll 69 30 , , , cord-103345-v555a2ll 69 31 and and CC cord-103345-v555a2ll 69 32 one one CD cord-103345-v555a2ll 69 33 transport transport NN cord-103345-v555a2ll 69 34 system system NN cord-103345-v555a2ll 69 35 of of IN cord-103345-v555a2ll 69 36 a a DT cord-103345-v555a2ll 69 37 lower low JJR cord-103345-v555a2ll 69 38 affinity affinity NN cord-103345-v555a2ll 69 39 in in IN cord-103345-v555a2ll 69 40 M1 M1 NNP cord-103345-v555a2ll 69 41 and and CC cord-103345-v555a2ll 69 42 M2 M2 NNP cord-103345-v555a2ll 69 43 cells cell NNS cord-103345-v555a2ll 69 44 . . . cord-103345-v555a2ll 70 1 As as IN cord-103345-v555a2ll 70 2 further further RB cord-103345-v555a2ll 70 3 shown show VBN cord-103345-v555a2ll 70 4 in in IN cord-103345-v555a2ll 70 5 Fig Fig NNP cord-103345-v555a2ll 70 6 . . . cord-103345-v555a2ll 71 1 2C 2C NNP cord-103345-v555a2ll 71 2 , , , cord-103345-v555a2ll 71 3 Ctrl ctrl NN cord-103345-v555a2ll 71 4 fibroblasts fibroblast NNS cord-103345-v555a2ll 71 5 , , , cord-103345-v555a2ll 71 6 high high JJ cord-103345-v555a2ll 71 7 affinity affinity NN cord-103345-v555a2ll 71 8 ( ( -LRB- cord-103345-v555a2ll 71 9 K1 K1 NNP cord-103345-v555a2ll 71 10 = = SYM cord-103345-v555a2ll 71 11 66.5 66.5 CD cord-103345-v555a2ll 71 12 ± ± CD cord-103345-v555a2ll 71 13 8.5 8.5 CD cord-103345-v555a2ll 71 14 µM µM NNS cord-103345-v555a2ll 71 15 ) ) -RRB- cord-103345-v555a2ll 71 16 and and CC cord-103345-v555a2ll 71 17 low low JJ cord-103345-v555a2ll 71 18 ( ( -LRB- cord-103345-v555a2ll 71 19 K2 k2 NN cord-103345-v555a2ll 71 20 = = NFP cord-103345-v555a2ll 72 1 299.0 299.0 CD cord-103345-v555a2ll 72 2 ± ± CD cord-103345-v555a2ll 72 3 13.1 13.1 CD cord-103345-v555a2ll 73 1 µM µm LS cord-103345-v555a2ll 73 2 ) ) -RRB- cord-103345-v555a2ll 73 3 affinity affinity NN cord-103345-v555a2ll 74 1 Etn etn IN cord-103345-v555a2ll 74 2 bindings binding NNS cord-103345-v555a2ll 74 3 were be VBD cord-103345-v555a2ll 74 4 similar similar JJ cord-103345-v555a2ll 74 5 to to IN cord-103345-v555a2ll 74 6 COS-7 cos-7 NN cord-103345-v555a2ll 74 7 cells cell NNS cord-103345-v555a2ll 74 8 bindings binding NNS cord-103345-v555a2ll 74 9 ( ( -LRB- cord-103345-v555a2ll 74 10 K1 K1 NNP cord-103345-v555a2ll 74 11 = = SYM cord-103345-v555a2ll 74 12 55.6 55.6 CD cord-103345-v555a2ll 74 13 ± ± CD cord-103345-v555a2ll 74 14 14.8 14.8 CD cord-103345-v555a2ll 74 15 µM µM NNP cord-103345-v555a2ll 74 16 and and CC cord-103345-v555a2ll 74 17 K2 K2 NNP cord-103345-v555a2ll 75 1 = = LS cord-103345-v555a2ll 75 2 277.3 277.3 CD cord-103345-v555a2ll 75 3 ± ± CD cord-103345-v555a2ll 75 4 7.9 7.9 CD cord-103345-v555a2ll 75 5 µM µM NNP cord-103345-v555a2ll 75 6 ) ) -RRB- cord-103345-v555a2ll 75 7 . . . cord-103345-v555a2ll 76 1 On on IN cord-103345-v555a2ll 76 2 the the DT cord-103345-v555a2ll 76 3 other other JJ cord-103345-v555a2ll 76 4 hand hand NN cord-103345-v555a2ll 76 5 , , , cord-103345-v555a2ll 76 6 M1 M1 NNP cord-103345-v555a2ll 76 7 and and CC cord-103345-v555a2ll 76 8 M2 M2 NNP cord-103345-v555a2ll 76 9 cells cell NNS cord-103345-v555a2ll 76 10 are be VBP cord-103345-v555a2ll 76 11 characterized characterize VBN cord-103345-v555a2ll 76 12 by by IN cord-103345-v555a2ll 76 13 a a DT cord-103345-v555a2ll 76 14 single single JJ cord-103345-v555a2ll 76 15 transport transport NN cord-103345-v555a2ll 76 16 with with IN cord-103345-v555a2ll 76 17 a a DT cord-103345-v555a2ll 76 18 binding binding JJ cord-103345-v555a2ll 76 19 constant constant NN cord-103345-v555a2ll 76 20 for for IN cord-103345-v555a2ll 76 21 Etn Etn NNP cord-103345-v555a2ll 76 22 of of IN cord-103345-v555a2ll 76 23 275.4 275.4 CD cord-103345-v555a2ll 76 24 -279.6 -279.6 NN cord-103345-v555a2ll 77 1 µM µM NFP cord-103345-v555a2ll 77 2 which which WDT cord-103345-v555a2ll 77 3 is be VBZ cord-103345-v555a2ll 77 4 the the DT cord-103345-v555a2ll 77 5 second second JJ cord-103345-v555a2ll 77 6 ( ( -LRB- cord-103345-v555a2ll 77 7 K2 K2 NNP cord-103345-v555a2ll 77 8 ) ) -RRB- cord-103345-v555a2ll 77 9 , , , cord-103345-v555a2ll 77 10 low low JJ cord-103345-v555a2ll 77 11 affinity affinity NN cord-103345-v555a2ll 77 12 , , , cord-103345-v555a2ll 77 13 binding bind VBG cord-103345-v555a2ll 77 14 constant constant JJ cord-103345-v555a2ll 77 15 as as IN cord-103345-v555a2ll 77 16 determined determine VBN cord-103345-v555a2ll 77 17 in in IN cord-103345-v555a2ll 77 18 Ctrl ctrl NN cord-103345-v555a2ll 77 19 and and CC cord-103345-v555a2ll 77 20 COS-7 COS-7 NNP cord-103345-v555a2ll 77 21 cells cell NNS cord-103345-v555a2ll 77 22 ( ( -LRB- cord-103345-v555a2ll 77 23 Fig Fig NNP cord-103345-v555a2ll 77 24 . . . cord-103345-v555a2ll 77 25 2C 2C NNP cord-103345-v555a2ll 77 26 ) ) -RRB- cord-103345-v555a2ll 77 27 . . . cord-103345-v555a2ll 78 1 M1 M1 NNP cord-103345-v555a2ll 78 2 and and CC cord-103345-v555a2ll 78 3 M2 M2 NNP cord-103345-v555a2ll 78 4 cells cell NNS cord-103345-v555a2ll 78 5 only only RB cord-103345-v555a2ll 78 6 express express VBP cord-103345-v555a2ll 78 7 CTL2 CTL2 NNP cord-103345-v555a2ll 78 8 and and CC cord-103345-v555a2ll 78 9 at at IN cord-103345-v555a2ll 78 10 levels level NNS cord-103345-v555a2ll 78 11 similar similar JJ cord-103345-v555a2ll 78 12 to to IN cord-103345-v555a2ll 78 13 Ctrl Ctrl NNP cord-103345-v555a2ll 78 14 and and CC cord-103345-v555a2ll 78 15 Cos Cos NNP cord-103345-v555a2ll 78 16 7 7 CD cord-103345-v555a2ll 78 17 cells cell NNS cord-103345-v555a2ll 78 18 , , , cord-103345-v555a2ll 78 19 and and CC cord-103345-v555a2ll 78 20 do do VBP cord-103345-v555a2ll 78 21 not not RB cord-103345-v555a2ll 78 22 have have VB cord-103345-v555a2ll 78 23 a a DT cord-103345-v555a2ll 78 24 functional functional JJ cord-103345-v555a2ll 78 25 CTL1 CTL1 NNP cord-103345-v555a2ll 78 26 protein protein NN cord-103345-v555a2ll 78 27 ( ( -LRB- cord-103345-v555a2ll 78 28 Fig Fig NNP cord-103345-v555a2ll 78 29 . . . cord-103345-v555a2ll 78 30 2A 2a CD cord-103345-v555a2ll 78 31 , , , cord-103345-v555a2ll 78 32 D D NNP cord-103345-v555a2ll 78 33 ) ) -RRB- cord-103345-v555a2ll 78 34 , , , cord-103345-v555a2ll 78 35 strongly strongly RB cord-103345-v555a2ll 78 36 implicating implicate VBG cord-103345-v555a2ll 78 37 CTL2 CTL2 NNP cord-103345-v555a2ll 78 38 as as IN cord-103345-v555a2ll 78 39 responsible responsible JJ cord-103345-v555a2ll 78 40 for for IN cord-103345-v555a2ll 78 41 the the DT cord-103345-v555a2ll 78 42 low low JJ cord-103345-v555a2ll 78 43 affinity affinity NN cord-103345-v555a2ll 79 1 Etn etn IN cord-103345-v555a2ll 79 2 transport transport NN cord-103345-v555a2ll 79 3 . . . cord-103345-v555a2ll 80 1 Indeed indeed RB cord-103345-v555a2ll 80 2 , , , cord-103345-v555a2ll 80 3 CTL2 CTL2 NNP cord-103345-v555a2ll 80 4 depletion depletion NN cord-103345-v555a2ll 80 5 by by IN cord-103345-v555a2ll 80 6 siRNA siRNA NNP cord-103345-v555a2ll 80 7 knockdown knockdown NN cord-103345-v555a2ll 80 8 in in IN cord-103345-v555a2ll 80 9 Ctrl ctrl NN cord-103345-v555a2ll 80 10 cells cell NNS cord-103345-v555a2ll 80 11 completely completely RB cord-103345-v555a2ll 80 12 abolished abolish VBD cord-103345-v555a2ll 80 13 the the DT cord-103345-v555a2ll 80 14 low low JJ cord-103345-v555a2ll 80 15 affinity affinity NN cord-103345-v555a2ll 80 16 transport transport NN cord-103345-v555a2ll 80 17 component component NN cord-103345-v555a2ll 80 18 while while IN cord-103345-v555a2ll 80 19 the the DT cord-103345-v555a2ll 80 20 high high JJ cord-103345-v555a2ll 80 21 affinity affinity NN cord-103345-v555a2ll 80 22 component component NN cord-103345-v555a2ll 80 23 remained remain VBD cord-103345-v555a2ll 80 24 intact intact JJ cord-103345-v555a2ll 80 25 ( ( -LRB- cord-103345-v555a2ll 80 26 Fig Fig NNP cord-103345-v555a2ll 80 27 . . . cord-103345-v555a2ll 80 28 2E 2E NNP cord-103345-v555a2ll 80 29 ) ) -RRB- cord-103345-v555a2ll 80 30 . . . cord-103345-v555a2ll 81 1 This this DT cord-103345-v555a2ll 81 2 analysis analysis NN cord-103345-v555a2ll 81 3 also also RB cord-103345-v555a2ll 81 4 confirmed confirm VBD cord-103345-v555a2ll 81 5 that that IN cord-103345-v555a2ll 81 6 the the DT cord-103345-v555a2ll 81 7 high high JJ cord-103345-v555a2ll 81 8 affinity affinity NN cord-103345-v555a2ll 81 9 transport transport NN cord-103345-v555a2ll 81 10 ( ( -LRB- cord-103345-v555a2ll 81 11 K1 K1 NNP cord-103345-v555a2ll 81 12 ) ) -RRB- cord-103345-v555a2ll 81 13 which which WDT cord-103345-v555a2ll 81 14 is be VBZ cord-103345-v555a2ll 81 15 absent absent JJ cord-103345-v555a2ll 81 16 in in IN cord-103345-v555a2ll 81 17 M1 M1 NNP cord-103345-v555a2ll 81 18 and and CC cord-103345-v555a2ll 81 19 M2 M2 NNP cord-103345-v555a2ll 81 20 cells cell NNS cord-103345-v555a2ll 81 21 and and CC cord-103345-v555a2ll 81 22 remained remain VBD cord-103345-v555a2ll 81 23 intact intact JJ cord-103345-v555a2ll 81 24 in in IN cord-103345-v555a2ll 81 25 CTL2 CTL2 NNP cord-103345-v555a2ll 81 26 siRNA siRNA NNP cord-103345-v555a2ll 82 1 treated treat VBN cord-103345-v555a2ll 82 2 Ctrl ctrl NN cord-103345-v555a2ll 82 3 is be VBZ cord-103345-v555a2ll 82 4 CTL1-mediated ctl1-mediate VBN cord-103345-v555a2ll 83 1 Etn etn IN cord-103345-v555a2ll 83 2 transport transport NN cord-103345-v555a2ll 83 3 . . . cord-103345-v555a2ll 84 1 Since since IN cord-103345-v555a2ll 84 2 the the DT cord-103345-v555a2ll 84 3 effects effect NNS cord-103345-v555a2ll 84 4 of of IN cord-103345-v555a2ll 84 5 pH ph NN cord-103345-v555a2ll 84 6 and and CC cord-103345-v555a2ll 84 7 [ [ -LRB- cord-103345-v555a2ll 84 8 Na Na NNP cord-103345-v555a2ll 84 9 + + CC cord-103345-v555a2ll 84 10 ] ] -RRB- cord-103345-v555a2ll 84 11 ions ion NNS cord-103345-v555a2ll 84 12 on on IN cord-103345-v555a2ll 84 13 choline choline NN cord-103345-v555a2ll 84 14 transport transport NN cord-103345-v555a2ll 84 15 is be VBZ cord-103345-v555a2ll 84 16 well well RB cord-103345-v555a2ll 84 17 established establish VBN cord-103345-v555a2ll 84 18 ( ( -LRB- cord-103345-v555a2ll 84 19 19 19 CD cord-103345-v555a2ll 84 20 ) ) -RRB- cord-103345-v555a2ll 84 21 , , , cord-103345-v555a2ll 84 22 their -PRON- PRP$ cord-103345-v555a2ll 84 23 effects effect NNS cord-103345-v555a2ll 84 24 on on IN cord-103345-v555a2ll 84 25 Etn etn PRP$ cord-103345-v555a2ll 84 26 transport transport NN cord-103345-v555a2ll 84 27 were be VBD cord-103345-v555a2ll 84 28 also also RB cord-103345-v555a2ll 84 29 investigated investigate VBN cord-103345-v555a2ll 84 30 ( ( -LRB- cord-103345-v555a2ll 84 31 Fig Fig NNP cord-103345-v555a2ll 84 32 . . . cord-103345-v555a2ll 84 33 2F 2F NNP cord-103345-v555a2ll 84 34 and and CC cord-103345-v555a2ll 84 35 G G NNP cord-103345-v555a2ll 84 36 ) ) -RRB- cord-103345-v555a2ll 84 37 . . . cord-103345-v555a2ll 85 1 Etn etn IN cord-103345-v555a2ll 85 2 transport transport NN cord-103345-v555a2ll 85 3 in in IN cord-103345-v555a2ll 85 4 Ctrl ctrl NN cord-103345-v555a2ll 85 5 ( ( -LRB- cord-103345-v555a2ll 85 6 CTL1 CTL1 NNP cord-103345-v555a2ll 85 7 + + CC cord-103345-v555a2ll 85 8 CTL2 CTL2 NNP cord-103345-v555a2ll 85 9 transport transport NN cord-103345-v555a2ll 85 10 ) ) -RRB- cord-103345-v555a2ll 85 11 and and CC cord-103345-v555a2ll 85 12 M2 m2 JJ cord-103345-v555a2ll 85 13 fibroblasts fibroblast NNS cord-103345-v555a2ll 85 14 ( ( -LRB- cord-103345-v555a2ll 85 15 CTL2 CTL2 NNP cord-103345-v555a2ll 85 16 transport transport NN cord-103345-v555a2ll 85 17 ) ) -RRB- cord-103345-v555a2ll 86 1 ( ( -LRB- cord-103345-v555a2ll 86 2 Fig Fig NNP cord-103345-v555a2ll 86 3 . . . cord-103345-v555a2ll 86 4 2F 2F NNP cord-103345-v555a2ll 86 5 ) ) -RRB- cord-103345-v555a2ll 86 6 was be VBD cord-103345-v555a2ll 86 7 reduced reduce VBN cord-103345-v555a2ll 86 8 when when WRB cord-103345-v555a2ll 86 9 extracellular extracellular JJ cord-103345-v555a2ll 86 10 pH ph NN cord-103345-v555a2ll 86 11 was be VBD cord-103345-v555a2ll 86 12 lowered lower VBN cord-103345-v555a2ll 86 13 from from IN cord-103345-v555a2ll 86 14 7 7 CD cord-103345-v555a2ll 86 15 to to IN cord-103345-v555a2ll 86 16 5.5 5.5 CD cord-103345-v555a2ll 86 17 and and CC cord-103345-v555a2ll 86 18 stimulated stimulate VBN cord-103345-v555a2ll 86 19 when when WRB cord-103345-v555a2ll 86 20 pH pH NNP cord-103345-v555a2ll 86 21 was be VBD cord-103345-v555a2ll 86 22 increased increase VBN cord-103345-v555a2ll 86 23 to to IN cord-103345-v555a2ll 86 24 8.5 8.5 CD cord-103345-v555a2ll 86 25 . . . cord-103345-v555a2ll 87 1 Additionally additionally RB cord-103345-v555a2ll 87 2 ( ( -LRB- cord-103345-v555a2ll 87 3 Fig fig NN cord-103345-v555a2ll 87 4 . . . cord-103345-v555a2ll 87 5 _SP cord-103345-v555a2ll 87 6 2 2 CD cord-103345-v555a2ll 87 7 G G NNP cord-103345-v555a2ll 87 8 ) ) -RRB- cord-103345-v555a2ll 87 9 , , , cord-103345-v555a2ll 87 10 as as IN cord-103345-v555a2ll 87 11 expected expect VBN cord-103345-v555a2ll 87 12 , , , cord-103345-v555a2ll 87 13 the the DT cord-103345-v555a2ll 87 14 rate rate NN cord-103345-v555a2ll 87 15 of of IN cord-103345-v555a2ll 87 16 Etn Etn NNP cord-103345-v555a2ll 87 17 transport transport NN cord-103345-v555a2ll 87 18 in in IN cord-103345-v555a2ll 87 19 Ctrl ctrl NN cord-103345-v555a2ll 87 20 cells cell NNS cord-103345-v555a2ll 87 21 was be VBD cord-103345-v555a2ll 87 22 higher high JJR cord-103345-v555a2ll 87 23 than than IN cord-103345-v555a2ll 87 24 in in IN cord-103345-v555a2ll 87 25 M2 M2 NNP cord-103345-v555a2ll 87 26 cells cell NNS cord-103345-v555a2ll 87 27 but but CC cord-103345-v555a2ll 87 28 the the DT cord-103345-v555a2ll 87 29 rates rate NNS cord-103345-v555a2ll 87 30 were be VBD cord-103345-v555a2ll 87 31 not not RB cord-103345-v555a2ll 87 32 modified modify VBN cord-103345-v555a2ll 87 33 when when WRB cord-103345-v555a2ll 87 34 Na Na NNP cord-103345-v555a2ll 87 35 + + CC cord-103345-v555a2ll 87 36 ions ion NNS cord-103345-v555a2ll 87 37 were be VBD cord-103345-v555a2ll 87 38 replaced replace VBN cord-103345-v555a2ll 87 39 by by IN cord-103345-v555a2ll 87 40 Li Li NNP cord-103345-v555a2ll 87 41 + + CC cord-103345-v555a2ll 87 42 ions ion NNS cord-103345-v555a2ll 87 43 in in IN cord-103345-v555a2ll 87 44 the the DT cord-103345-v555a2ll 87 45 uptake uptake NN cord-103345-v555a2ll 87 46 buffer buffer NN cord-103345-v555a2ll 87 47 . . . cord-103345-v555a2ll 88 1 Altogether altogether RB cord-103345-v555a2ll 88 2 , , , cord-103345-v555a2ll 88 3 the the DT cord-103345-v555a2ll 88 4 data datum NNS cord-103345-v555a2ll 88 5 established establish VBD cord-103345-v555a2ll 88 6 that that IN cord-103345-v555a2ll 88 7 CTL1 CTL1 NNP cord-103345-v555a2ll 88 8 and and CC cord-103345-v555a2ll 88 9 CTL2 CTL2 NNP cord-103345-v555a2ll 88 10 acts act VBZ cord-103345-v555a2ll 88 11 as as IN cord-103345-v555a2ll 88 12 Etn Etn NNP cord-103345-v555a2ll 88 13 / / SYM cord-103345-v555a2ll 88 14 H h NN cord-103345-v555a2ll 88 15 + + SYM cord-103345-v555a2ll 88 16 antiporters antiporter NNS cord-103345-v555a2ll 88 17 , , , cord-103345-v555a2ll 88 18 driven drive VBN cord-103345-v555a2ll 88 19 by by IN cord-103345-v555a2ll 88 20 a a DT cord-103345-v555a2ll 88 21 proton proton NN cord-103345-v555a2ll 88 22 gradient gradient NN cord-103345-v555a2ll 88 23 and and CC cord-103345-v555a2ll 88 24 they -PRON- PRP cord-103345-v555a2ll 88 25 are be VBP cord-103345-v555a2ll 88 26 both both DT cord-103345-v555a2ll 88 27 independent independent JJ cord-103345-v555a2ll 88 28 of of IN cord-103345-v555a2ll 88 29 Na Na NNP cord-103345-v555a2ll 88 30 + + CC cord-103345-v555a2ll 88 31 , , , cord-103345-v555a2ll 88 32 as as IN cord-103345-v555a2ll 88 33 in in IN cord-103345-v555a2ll 88 34 case case NN cord-103345-v555a2ll 88 35 of of IN cord-103345-v555a2ll 88 36 Cho Cho NNP cord-103345-v555a2ll 88 37 transport transport NN cord-103345-v555a2ll 88 38 ( ( -LRB- cord-103345-v555a2ll 88 39 19 19 CD cord-103345-v555a2ll 88 40 ) ) -RRB- cord-103345-v555a2ll 88 41 . . . cord-103345-v555a2ll 89 1 state state NN cord-103345-v555a2ll 89 2 levels level NNS cord-103345-v555a2ll 89 3 ) ) -RRB- cord-103345-v555a2ll 89 4 showed show VBD cord-103345-v555a2ll 89 5 unchanged unchanged JJ cord-103345-v555a2ll 89 6 PC pc NN cord-103345-v555a2ll 89 7 , , , cord-103345-v555a2ll 89 8 reduced reduce VBN cord-103345-v555a2ll 89 9 PE PE NNP cord-103345-v555a2ll 89 10 , , , cord-103345-v555a2ll 89 11 PS PS NNP cord-103345-v555a2ll 89 12 and and CC cord-103345-v555a2ll 89 13 DAG DAG NNP cord-103345-v555a2ll 89 14 and and CC cord-103345-v555a2ll 89 15 increased increase VBD cord-103345-v555a2ll 89 16 triglycerides triglyceride NNS cord-103345-v555a2ll 89 17 ( ( -LRB- cord-103345-v555a2ll 89 18 TAG TAG NNP cord-103345-v555a2ll 89 19 ) ) -RRB- cord-103345-v555a2ll 89 20 in in IN cord-103345-v555a2ll 89 21 M2 M2 NNP cord-103345-v555a2ll 89 22 cells cell NNS cord-103345-v555a2ll 89 23 ( ( -LRB- cord-103345-v555a2ll 89 24 Fig Fig NNP cord-103345-v555a2ll 89 25 . . . cord-103345-v555a2ll 89 26 3C 3C NNP cord-103345-v555a2ll 89 27 and and CC cord-103345-v555a2ll 89 28 D D NNP cord-103345-v555a2ll 89 29 ) ) -RRB- cord-103345-v555a2ll 89 30 . . . cord-103345-v555a2ll 90 1 Therefore therefore RB cord-103345-v555a2ll 90 2 , , , cord-103345-v555a2ll 90 3 reduced reduce VBN cord-103345-v555a2ll 90 4 Etn etn CC cord-103345-v555a2ll 90 5 transport transport NN cord-103345-v555a2ll 90 6 , , , cord-103345-v555a2ll 90 7 slower slow JJR cord-103345-v555a2ll 90 8 P p NN cord-103345-v555a2ll 90 9 - - HYPH cord-103345-v555a2ll 90 10 Etn Etn NNP cord-103345-v555a2ll 90 11 and and CC cord-103345-v555a2ll 90 12 CDP CDP NNP cord-103345-v555a2ll 90 13 - - HYPH cord-103345-v555a2ll 90 14 Etn Etn NNP cord-103345-v555a2ll 90 15 formation formation NN cord-103345-v555a2ll 90 16 , , , cord-103345-v555a2ll 90 17 and and CC cord-103345-v555a2ll 90 18 reduced reduce VBN cord-103345-v555a2ll 90 19 DAG DAG NNP cord-103345-v555a2ll 90 20 levels level NNS cord-103345-v555a2ll 90 21 , , , cord-103345-v555a2ll 90 22 collectively collectively RB cord-103345-v555a2ll 90 23 slowed slow VBD cord-103345-v555a2ll 90 24 the the DT cord-103345-v555a2ll 90 25 CDP CDP NNP cord-103345-v555a2ll 90 26 - - HYPH cord-103345-v555a2ll 90 27 Etn Etn NNP cord-103345-v555a2ll 90 28 pathway pathway NN cord-103345-v555a2ll 90 29 ( ( -LRB- cord-103345-v555a2ll 90 30 Fig Fig NNP cord-103345-v555a2ll 90 31 . . . cord-103345-v555a2ll 90 32 3A 3A NNP cord-103345-v555a2ll 90 33 , , , cord-103345-v555a2ll 90 34 B B NNP cord-103345-v555a2ll 90 35 ) ) -RRB- cord-103345-v555a2ll 90 36 and and CC cord-103345-v555a2ll 90 37 reduced reduce VBN cord-103345-v555a2ll 90 38 PE PE NNP cord-103345-v555a2ll 90 39 levels level NNS cord-103345-v555a2ll 90 40 ( ( -LRB- cord-103345-v555a2ll 90 41 Fig Fig NNP cord-103345-v555a2ll 90 42 . . . cord-103345-v555a2ll 90 43 3C 3C NNP cord-103345-v555a2ll 90 44 ) ) -RRB- cord-103345-v555a2ll 90 45 in in IN cord-103345-v555a2ll 90 46 M2 M2 NNP cord-103345-v555a2ll 90 47 cells cell NNS cord-103345-v555a2ll 90 48 . . . cord-103345-v555a2ll 91 1 The the DT cord-103345-v555a2ll 91 2 CDP CDP NNP cord-103345-v555a2ll 91 3 - - HYPH cord-103345-v555a2ll 91 4 Etn Etn NNP cord-103345-v555a2ll 91 5 formation formation NN cord-103345-v555a2ll 91 6 from from IN cord-103345-v555a2ll 91 7 PEtn PEtn NNP cord-103345-v555a2ll 91 8 is be VBZ cord-103345-v555a2ll 91 9 usually usually RB cord-103345-v555a2ll 91 10 the the DT cord-103345-v555a2ll 91 11 rate rate NN cord-103345-v555a2ll 91 12 - - HYPH cord-103345-v555a2ll 91 13 regulatory regulatory JJ cord-103345-v555a2ll 91 14 step step NN cord-103345-v555a2ll 91 15 in in IN cord-103345-v555a2ll 91 16 the the DT cord-103345-v555a2ll 91 17 Kennedy Kennedy NNP cord-103345-v555a2ll 91 18 pathway pathway NN cord-103345-v555a2ll 91 19 and and CC cord-103345-v555a2ll 91 20 is be VBZ cord-103345-v555a2ll 91 21 controlled control VBN cord-103345-v555a2ll 91 22 by by IN cord-103345-v555a2ll 92 1 Pcyt2 Pcyt2 NNP cord-103345-v555a2ll 92 2 ( ( -LRB- cord-103345-v555a2ll 92 3 CTP CTP NNP cord-103345-v555a2ll 92 4 : : : cord-103345-v555a2ll 92 5 phosphoethanolamine phosphoethanolamine NNP cord-103345-v555a2ll 92 6 cytidylyltransferase cytidylyltransferase NNP cord-103345-v555a2ll 92 7 ) ) -RRB- cord-103345-v555a2ll 92 8 ( ( -LRB- cord-103345-v555a2ll 92 9 11 11 CD cord-103345-v555a2ll 92 10 ) ) -RRB- cord-103345-v555a2ll 92 11 . . . cord-103345-v555a2ll 93 1 Indeed indeed RB cord-103345-v555a2ll 93 2 , , , cord-103345-v555a2ll 93 3 in in IN cord-103345-v555a2ll 93 4 accordance accordance NN cord-103345-v555a2ll 93 5 with with IN cord-103345-v555a2ll 93 6 reduced reduce VBN cord-103345-v555a2ll 93 7 CDP CDP NNP cord-103345-v555a2ll 93 8 - - HYPH cord-103345-v555a2ll 93 9 Etn Etn NNP cord-103345-v555a2ll 93 10 formation formation NN cord-103345-v555a2ll 93 11 above above RB cord-103345-v555a2ll 93 12 , , , cord-103345-v555a2ll 93 13 the the DT cord-103345-v555a2ll 93 14 activity activity NN cord-103345-v555a2ll 93 15 and and CC cord-103345-v555a2ll 93 16 expression expression NN cord-103345-v555a2ll 93 17 of of IN cord-103345-v555a2ll 93 18 Pcyt2 Pcyt2 NNP cord-103345-v555a2ll 93 19 were be VBD cord-103345-v555a2ll 93 20 also also RB cord-103345-v555a2ll 93 21 reduced reduce VBN cord-103345-v555a2ll 93 22 in in IN cord-103345-v555a2ll 93 23 M2 M2 NNP cord-103345-v555a2ll 93 24 cells cell NNS cord-103345-v555a2ll 93 25 ( ( -LRB- cord-103345-v555a2ll 93 26 Fig fig NN cord-103345-v555a2ll 93 27 . . . cord-103345-v555a2ll 93 28 3 3 CD cord-103345-v555a2ll 93 29 E e NN cord-103345-v555a2ll 93 30 , , , cord-103345-v555a2ll 93 31 F F NNP cord-103345-v555a2ll 93 32 ) ) -RRB- cord-103345-v555a2ll 93 33 . . . cord-103345-v555a2ll 94 1 The the DT cord-103345-v555a2ll 94 2 expression expression NN cord-103345-v555a2ll 94 3 of of IN cord-103345-v555a2ll 94 4 Etn Etn NNP cord-103345-v555a2ll 94 5 kinase kinase NN cord-103345-v555a2ll 94 6 ( ( -LRB- cord-103345-v555a2ll 94 7 EK EK NNP cord-103345-v555a2ll 94 8 ) ) -RRB- cord-103345-v555a2ll 94 9 was be VBD cord-103345-v555a2ll 94 10 similarly similarly RB cord-103345-v555a2ll 94 11 decreased decrease VBN cord-103345-v555a2ll 94 12 by by IN cord-103345-v555a2ll 94 13 25 25 CD cord-103345-v555a2ll 94 14 % % NN cord-103345-v555a2ll 94 15 ( ( -LRB- cord-103345-v555a2ll 94 16 Fig Fig NNP cord-103345-v555a2ll 94 17 . . . cord-103345-v555a2ll 94 18 3F 3F NNP cord-103345-v555a2ll 94 19 ) ) -RRB- cord-103345-v555a2ll 94 20 , , , cord-103345-v555a2ll 94 21 explaining explain VBG cord-103345-v555a2ll 94 22 why why WRB cord-103345-v555a2ll 94 23 the the DT cord-103345-v555a2ll 94 24 formation formation NN cord-103345-v555a2ll 94 25 of of IN cord-103345-v555a2ll 94 26 P p NN cord-103345-v555a2ll 94 27 - - : cord-103345-v555a2ll 94 28 Etn Etn NNP cord-103345-v555a2ll 94 29 was be VBD cord-103345-v555a2ll 94 30 reduced reduce VBN cord-103345-v555a2ll 94 31 in in IN cord-103345-v555a2ll 94 32 M2 M2 NNP cord-103345-v555a2ll 94 33 cells cell NNS cord-103345-v555a2ll 94 34 ( ( -LRB- cord-103345-v555a2ll 94 35 Fig Fig NNP cord-103345-v555a2ll 94 36 . . . cord-103345-v555a2ll 94 37 _SP cord-103345-v555a2ll 94 38 3A 3a NN cord-103345-v555a2ll 94 39 , , , cord-103345-v555a2ll 94 40 B B NNP cord-103345-v555a2ll 94 41 ) ) -RRB- cord-103345-v555a2ll 94 42 . . . cord-103345-v555a2ll 95 1 In in IN cord-103345-v555a2ll 95 2 addition addition NN cord-103345-v555a2ll 95 3 to to IN cord-103345-v555a2ll 95 4 PE PE NNP cord-103345-v555a2ll 95 5 , , , cord-103345-v555a2ll 95 6 PS PS NNP cord-103345-v555a2ll 95 7 levels level NNS cord-103345-v555a2ll 95 8 were be VBD cord-103345-v555a2ll 95 9 reduced reduce VBN cord-103345-v555a2ll 95 10 in in IN cord-103345-v555a2ll 95 11 M2 m2 JJ cord-103345-v555a2ll 95 12 cells cell NNS cord-103345-v555a2ll 95 13 but but CC cord-103345-v555a2ll 95 14 the the DT cord-103345-v555a2ll 95 15 expression expression NN cord-103345-v555a2ll 95 16 of of IN cord-103345-v555a2ll 95 17 PS PS NNP cord-103345-v555a2ll 95 18 synthesis synthesis NN cord-103345-v555a2ll 95 19 ( ( -LRB- cord-103345-v555a2ll 95 20 PS PS NNP cord-103345-v555a2ll 95 21 syntase1/2-PSS1/2 syntase1/2-pss1/2 NN cord-103345-v555a2ll 95 22 ) ) -RRB- cord-103345-v555a2ll 95 23 and and CC cord-103345-v555a2ll 95 24 PS PS NNP cord-103345-v555a2ll 95 25 degradation degradation NN cord-103345-v555a2ll 95 26 ( ( -LRB- cord-103345-v555a2ll 95 27 PS PS NNP cord-103345-v555a2ll 95 28 decarboxylase decarboxylase NNP cord-103345-v555a2ll 95 29 - - HYPH cord-103345-v555a2ll 95 30 PSD PSD NNP cord-103345-v555a2ll 95 31 ) ) -RRB- cord-103345-v555a2ll 95 32 genes gene NNS cord-103345-v555a2ll 95 33 ( ( -LRB- cord-103345-v555a2ll 95 34 Fig.3F Fig.3F NNP cord-103345-v555a2ll 95 35 ) ) -RRB- cord-103345-v555a2ll 95 36 were be VBD cord-103345-v555a2ll 95 37 unaltered unaltered JJ cord-103345-v555a2ll 96 1 ( ( -LRB- cord-103345-v555a2ll 96 2 Fig Fig NNP cord-103345-v555a2ll 96 3 3C 3C NNP cord-103345-v555a2ll 96 4 ) ) -RRB- cord-103345-v555a2ll 96 5 . . . cord-103345-v555a2ll 97 1 The the DT cord-103345-v555a2ll 97 2 expression expression NN cord-103345-v555a2ll 97 3 of of IN cord-103345-v555a2ll 97 4 the the DT cord-103345-v555a2ll 97 5 PC pc NN cord-103345-v555a2ll 97 6 synthesis synthesis NN cord-103345-v555a2ll 97 7 genes gene NNS cord-103345-v555a2ll 97 8 Pcyt1 Pcyt1 NNP cord-103345-v555a2ll 97 9 ( ( -LRB- cord-103345-v555a2ll 97 10 CTP CTP NNP cord-103345-v555a2ll 97 11 : : : cord-103345-v555a2ll 97 12 phosphocholine phosphocholine NNP cord-103345-v555a2ll 97 13 cytidylyltransferase cytidylyltransferase NNP cord-103345-v555a2ll 97 14 ) ) -RRB- cord-103345-v555a2ll 97 15 was be VBD cord-103345-v555a2ll 97 16 decreased decrease VBN cord-103345-v555a2ll 97 17 by by IN cord-103345-v555a2ll 97 18 70 70 CD cord-103345-v555a2ll 97 19 % % NN cord-103345-v555a2ll 97 20 and and CC cord-103345-v555a2ll 97 21 choline choline NN cord-103345-v555a2ll 97 22 kinase kinase NN cord-103345-v555a2ll 97 23 ( ( -LRB- cord-103345-v555a2ll 97 24 CK CK NNP cord-103345-v555a2ll 97 25 ) ) -RRB- cord-103345-v555a2ll 97 26 by by IN cord-103345-v555a2ll 97 27 25 25 CD cord-103345-v555a2ll 97 28 % % NN cord-103345-v555a2ll 97 29 in in IN cord-103345-v555a2ll 97 30 M2 M2 NNP cord-103345-v555a2ll 97 31 cells cell NNS cord-103345-v555a2ll 97 32 ( ( -LRB- cord-103345-v555a2ll 97 33 Fig Fig NNP cord-103345-v555a2ll 97 34 . . . cord-103345-v555a2ll 97 35 _SP cord-103345-v555a2ll 97 36 3F 3F NNP cord-103345-v555a2ll 97 37 ) ) -RRB- cord-103345-v555a2ll 97 38 , , , cord-103345-v555a2ll 97 39 yet yet CC cord-103345-v555a2ll 97 40 unexpectedly unexpectedly RB cord-103345-v555a2ll 97 41 PC pc NN cord-103345-v555a2ll 97 42 levels level NNS cord-103345-v555a2ll 97 43 were be VBD cord-103345-v555a2ll 97 44 unchanged unchanged JJ cord-103345-v555a2ll 97 45 ( ( -LRB- cord-103345-v555a2ll 97 46 Fig Fig NNP cord-103345-v555a2ll 97 47 . . . cord-103345-v555a2ll 97 48 3C 3C NNP cord-103345-v555a2ll 97 49 ) ) -RRB- cord-103345-v555a2ll 97 50 . . . cord-103345-v555a2ll 98 1 We -PRON- PRP cord-103345-v555a2ll 98 2 previously previously RB cord-103345-v555a2ll 98 3 established establish VBD cord-103345-v555a2ll 98 4 ( ( -LRB- cord-103345-v555a2ll 98 5 15 15 CD cord-103345-v555a2ll 98 6 ) ) -RRB- cord-103345-v555a2ll 98 7 that that IN cord-103345-v555a2ll 98 8 the the DT cord-103345-v555a2ll 98 9 constant constant JJ cord-103345-v555a2ll 98 10 PC pc NN cord-103345-v555a2ll 98 11 levels level NNS cord-103345-v555a2ll 98 12 in in IN cord-103345-v555a2ll 98 13 CTL1 ctl1 JJ cord-103345-v555a2ll 98 14 deficient deficient JJ cord-103345-v555a2ll 98 15 M1 M1 NNP cord-103345-v555a2ll 98 16 and and CC cord-103345-v555a2ll 98 17 M2 M2 NNP cord-103345-v555a2ll 98 18 cells cell NNS cord-103345-v555a2ll 98 19 are be VBP cord-103345-v555a2ll 98 20 maintained maintain VBN cord-103345-v555a2ll 98 21 by by IN cord-103345-v555a2ll 98 22 reduced reduce VBN cord-103345-v555a2ll 98 23 PC pc NN cord-103345-v555a2ll 98 24 turnover turnover NN cord-103345-v555a2ll 98 25 and and CC cord-103345-v555a2ll 98 26 increased increase VBN cord-103345-v555a2ll 98 27 formation formation NN cord-103345-v555a2ll 98 28 from from IN cord-103345-v555a2ll 98 29 other other JJ cord-103345-v555a2ll 98 30 phospholipids phospholipid NNS cord-103345-v555a2ll 98 31 ( ( -LRB- cord-103345-v555a2ll 98 32 PC pc NN cord-103345-v555a2ll 98 33 is be VBZ cord-103345-v555a2ll 98 34 made make VBN cord-103345-v555a2ll 98 35 at at IN cord-103345-v555a2ll 98 36 the the DT cord-103345-v555a2ll 98 37 expanse expanse NN cord-103345-v555a2ll 98 38 of of IN cord-103345-v555a2ll 98 39 PE PE NNP cord-103345-v555a2ll 98 40 and and CC cord-103345-v555a2ll 98 41 PS PS NNP cord-103345-v555a2ll 98 42 ) ) -RRB- cord-103345-v555a2ll 98 43 , , , cord-103345-v555a2ll 98 44 as as IN cord-103345-v555a2ll 98 45 the the DT cord-103345-v555a2ll 98 46 main main JJ cord-103345-v555a2ll 98 47 mechanism mechanism NN cord-103345-v555a2ll 98 48 to to TO cord-103345-v555a2ll 98 49 maintain maintain VB cord-103345-v555a2ll 98 50 PC pc NN cord-103345-v555a2ll 98 51 as as IN cord-103345-v555a2ll 98 52 a a DT cord-103345-v555a2ll 98 53 source source NN cord-103345-v555a2ll 98 54 of of IN cord-103345-v555a2ll 98 55 choline choline NN cord-103345-v555a2ll 98 56 in in IN cord-103345-v555a2ll 98 57 a a DT cord-103345-v555a2ll 98 58 new new JJ cord-103345-v555a2ll 98 59 neurodegenerative neurodegenerative JJ cord-103345-v555a2ll 98 60 disorder disorder NN cord-103345-v555a2ll 98 61 caused cause VBN cord-103345-v555a2ll 98 62 by by IN cord-103345-v555a2ll 98 63 frame frame NN cord-103345-v555a2ll 98 64 - - HYPH cord-103345-v555a2ll 98 65 shift shift NN cord-103345-v555a2ll 98 66 mutations mutation NNS cord-103345-v555a2ll 98 67 in in IN cord-103345-v555a2ll 98 68 the the DT cord-103345-v555a2ll 98 69 CTL1 CTL1 NNP cord-103345-v555a2ll 98 70 gene gene NN cord-103345-v555a2ll 98 71 M1 M1 NNP cord-103345-v555a2ll 98 72 = = SYM cord-103345-v555a2ll 98 73 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 98 74 ΔAsp517 ΔAsp517 NNS cord-103345-v555a2ll 98 75 and and CC cord-103345-v555a2ll 98 76 M2= M2= NNS cord-103345-v555a2ll 99 1 SLC44A21 SLC44A21 NNP cord-103345-v555a2ll 99 2 Ser126 ser126 ADD cord-103345-v555a2ll 100 1 ( ( -LRB- cord-103345-v555a2ll 100 2 15 15 CD cord-103345-v555a2ll 100 3 ) ) -RRB- cord-103345-v555a2ll 100 4 . . . cord-103345-v555a2ll 101 1 These these DT cord-103345-v555a2ll 101 2 data datum NNS cord-103345-v555a2ll 101 3 collectively collectively RB cord-103345-v555a2ll 101 4 provided provide VBD cord-103345-v555a2ll 101 5 strong strong JJ cord-103345-v555a2ll 101 6 genetic genetic JJ cord-103345-v555a2ll 101 7 and and CC cord-103345-v555a2ll 101 8 metabolic metabolic JJ cord-103345-v555a2ll 101 9 evidence evidence NN cord-103345-v555a2ll 101 10 that that IN cord-103345-v555a2ll 101 11 CTL1 CTL1 NNP cord-103345-v555a2ll 101 12 and and CC cord-103345-v555a2ll 101 13 CTL2 CTL2 NNP cord-103345-v555a2ll 101 14 independently independently RB cord-103345-v555a2ll 101 15 contributes contribute VBZ cord-103345-v555a2ll 101 16 not not RB cord-103345-v555a2ll 101 17 only only RB cord-103345-v555a2ll 101 18 to to IN cord-103345-v555a2ll 101 19 the the DT cord-103345-v555a2ll 101 20 CDP CDP NNP cord-103345-v555a2ll 101 21 - - HYPH cord-103345-v555a2ll 101 22 Cho Cho NNP cord-103345-v555a2ll 101 23 but but CC cord-103345-v555a2ll 101 24 also also RB cord-103345-v555a2ll 101 25 to to IN cord-103345-v555a2ll 101 26 the the DT cord-103345-v555a2ll 101 27 CDP CDP NNP cord-103345-v555a2ll 102 1 -Etn -etn JJ cord-103345-v555a2ll 102 2 Kennedy Kennedy NNP cord-103345-v555a2ll 102 3 pathway pathway NN cord-103345-v555a2ll 102 4 . . . cord-103345-v555a2ll 103 1 CTL2 CTL2 NNP cord-103345-v555a2ll 103 2 is be VBZ cord-103345-v555a2ll 103 3 not not RB cord-103345-v555a2ll 103 4 over over RB cord-103345-v555a2ll 103 5 expressed express VBN cord-103345-v555a2ll 103 6 in in IN cord-103345-v555a2ll 103 7 deficient deficient JJ cord-103345-v555a2ll 103 8 M1 M1 NNP cord-103345-v555a2ll 103 9 and and CC cord-103345-v555a2ll 103 10 M2 M2 NNP cord-103345-v555a2ll 103 11 cells cell NNS cord-103345-v555a2ll 103 12 ( ( -LRB- cord-103345-v555a2ll 103 13 Fig.2A Fig.2A NNP cord-103345-v555a2ll 103 14 ) ) -RRB- cord-103345-v555a2ll 103 15 and and CC cord-103345-v555a2ll 103 16 as as RB cord-103345-v555a2ll 103 17 such such JJ cord-103345-v555a2ll 103 18 it -PRON- PRP cord-103345-v555a2ll 103 19 can can MD cord-103345-v555a2ll 103 20 not not RB cord-103345-v555a2ll 103 21 compensate compensate VB cord-103345-v555a2ll 103 22 for for IN cord-103345-v555a2ll 103 23 the the DT cord-103345-v555a2ll 103 24 absence absence NN cord-103345-v555a2ll 103 25 of of IN cord-103345-v555a2ll 103 26 CTL1 CTL1 NNP cord-103345-v555a2ll 103 27 in in IN cord-103345-v555a2ll 103 28 those those DT cord-103345-v555a2ll 103 29 cells cell NNS cord-103345-v555a2ll 103 30 and and CC cord-103345-v555a2ll 103 31 affected affect VBN cord-103345-v555a2ll 103 32 individuals individual NNS cord-103345-v555a2ll 103 33 ( ( -LRB- cord-103345-v555a2ll 103 34 15 15 CD cord-103345-v555a2ll 103 35 ) ) -RRB- cord-103345-v555a2ll 103 36 . . . cord-103345-v555a2ll 104 1 To to TO cord-103345-v555a2ll 104 2 demonstrate demonstrate VB cord-103345-v555a2ll 104 3 that that IN cord-103345-v555a2ll 104 4 CTL1 CTL1 NNP cord-103345-v555a2ll 104 5 and and CC cord-103345-v555a2ll 104 6 CTL2 CTL2 NNP cord-103345-v555a2ll 104 7 are be VBP cord-103345-v555a2ll 104 8 both both DT cord-103345-v555a2ll 104 9 Etn Etn NNP cord-103345-v555a2ll 104 10 and and CC cord-103345-v555a2ll 104 11 Cho Cho NNP cord-103345-v555a2ll 104 12 transporters transporter NNS cord-103345-v555a2ll 104 13 , , , cord-103345-v555a2ll 104 14 the the DT cord-103345-v555a2ll 104 15 cells cell NNS cord-103345-v555a2ll 104 16 were be VBD cord-103345-v555a2ll 104 17 transiently transiently RB cord-103345-v555a2ll 104 18 transfected transfecte VBN cord-103345-v555a2ll 104 19 with with IN cord-103345-v555a2ll 104 20 CTL1 CTL1 NNP cord-103345-v555a2ll 104 21 cDNA cdna NN cord-103345-v555a2ll 104 22 or or CC cord-103345-v555a2ll 104 23 CTL2 CTL2 NNP cord-103345-v555a2ll 104 24 cDNA cdna NN cord-103345-v555a2ll 104 25 and and CC cord-103345-v555a2ll 104 26 the the DT cord-103345-v555a2ll 104 27 protein protein NN cord-103345-v555a2ll 104 28 expression expression NN cord-103345-v555a2ll 104 29 and and CC cord-103345-v555a2ll 104 30 transport transport NN cord-103345-v555a2ll 104 31 determined determine VBN cord-103345-v555a2ll 104 32 after after IN cord-103345-v555a2ll 104 33 48h 48h NNS cord-103345-v555a2ll 104 34 . . . cord-103345-v555a2ll 105 1 As as IN cord-103345-v555a2ll 105 2 shown show VBN cord-103345-v555a2ll 105 3 in in IN cord-103345-v555a2ll 105 4 Fig Fig NNP cord-103345-v555a2ll 105 5 . . . cord-103345-v555a2ll 105 6 4A 4a CD cord-103345-v555a2ll 105 7 , , , cord-103345-v555a2ll 105 8 in in IN cord-103345-v555a2ll 105 9 M2 M2 NNP cord-103345-v555a2ll 105 10 cells cell NNS cord-103345-v555a2ll 105 11 , , , cord-103345-v555a2ll 105 12 that that WDT cord-103345-v555a2ll 105 13 completely completely RB cord-103345-v555a2ll 105 14 lack lack VBP cord-103345-v555a2ll 105 15 CTL1 CTL1 NNP cord-103345-v555a2ll 105 16 protein protein NN cord-103345-v555a2ll 105 17 , , , cord-103345-v555a2ll 105 18 CTL1 CTL1 NNP cord-103345-v555a2ll 105 19 cDNA cdna NN cord-103345-v555a2ll 105 20 _SP cord-103345-v555a2ll 106 1 It -PRON- PRP cord-103345-v555a2ll 106 2 is be VBZ cord-103345-v555a2ll 106 3 well well RB cord-103345-v555a2ll 106 4 known know VBN cord-103345-v555a2ll 106 5 that that IN cord-103345-v555a2ll 106 6 various various JJ cord-103345-v555a2ll 106 7 organic organic JJ cord-103345-v555a2ll 106 8 cations cation NNS cord-103345-v555a2ll 106 9 can can MD cord-103345-v555a2ll 106 10 inhibit inhibit VB cord-103345-v555a2ll 106 11 CTL1 CTL1 NNP cord-103345-v555a2ll 106 12 mediated mediate VBN cord-103345-v555a2ll 106 13 Cho Cho NNP cord-103345-v555a2ll 106 14 transport transport NN cord-103345-v555a2ll 106 15 ( ( -LRB- cord-103345-v555a2ll 106 16 20 20 CD cord-103345-v555a2ll 106 17 ) ) -RRB- cord-103345-v555a2ll 106 18 . . . cord-103345-v555a2ll 107 1 We -PRON- PRP cord-103345-v555a2ll 107 2 assessed assess VBD cord-103345-v555a2ll 107 3 the the DT cord-103345-v555a2ll 107 4 inhibitory inhibitory JJ cord-103345-v555a2ll 107 5 effect effect NN cord-103345-v555a2ll 107 6 of of IN cord-103345-v555a2ll 107 7 organic organic JJ cord-103345-v555a2ll 107 8 cations cation NNS cord-103345-v555a2ll 107 9 and and CC cord-103345-v555a2ll 107 10 CTL2 CTL2 NNP cord-103345-v555a2ll 107 11 knockdown knockdown NN cord-103345-v555a2ll 107 12 on on IN cord-103345-v555a2ll 107 13 Etn Etn NNP cord-103345-v555a2ll 107 14 transport transport NN cord-103345-v555a2ll 107 15 in in IN cord-103345-v555a2ll 107 16 Ctrl ctrl NN cord-103345-v555a2ll 107 17 and and CC cord-103345-v555a2ll 107 18 M2 m2 NN cord-103345-v555a2ll 107 19 cells cell NNS cord-103345-v555a2ll 107 20 ( ( -LRB- cord-103345-v555a2ll 107 21 Fig Fig NNP cord-103345-v555a2ll 107 22 . . NNP cord-103345-v555a2ll 107 23 5 5 CD cord-103345-v555a2ll 107 24 ) ) -RRB- cord-103345-v555a2ll 107 25 . . . cord-103345-v555a2ll 108 1 This this DT cord-103345-v555a2ll 108 2 helped help VBD cord-103345-v555a2ll 108 3 us -PRON- PRP cord-103345-v555a2ll 108 4 understand understand VB cord-103345-v555a2ll 108 5 the the DT cord-103345-v555a2ll 108 6 magnitude magnitude NN cord-103345-v555a2ll 108 7 at at IN cord-103345-v555a2ll 108 8 which which WDT cord-103345-v555a2ll 108 9 CTL1 CTL1 NNP cord-103345-v555a2ll 108 10 and and CC cord-103345-v555a2ll 108 11 CTL2 CTL2 NNP cord-103345-v555a2ll 108 12 contributed contribute VBD cord-103345-v555a2ll 108 13 to to IN cord-103345-v555a2ll 108 14 Etn Etn NNP cord-103345-v555a2ll 108 15 transport transport VB cord-103345-v555a2ll 108 16 . . . cord-103345-v555a2ll 109 1 Total total JJ cord-103345-v555a2ll 109 2 ( ( -LRB- cord-103345-v555a2ll 109 3 CTL1+CTL2 CTL1+CTL2 NNP cord-103345-v555a2ll 109 4 ) ) -RRB- cord-103345-v555a2ll 109 5 transport transport NN cord-103345-v555a2ll 109 6 ( ( -LRB- cord-103345-v555a2ll 109 7 showing show VBG cord-103345-v555a2ll 109 8 that that DT cord-103345-v555a2ll 109 9 is be VBZ cord-103345-v555a2ll 109 10 not not RB cord-103345-v555a2ll 109 11 a a DT cord-103345-v555a2ll 109 12 CTL1/2 CTL1/2 NNP cord-103345-v555a2ll 109 13 related relate VBN cord-103345-v555a2ll 109 14 transport transport NN cord-103345-v555a2ll 109 15 . . . cord-103345-v555a2ll 110 1 Finally finally RB cord-103345-v555a2ll 110 2 , , , cord-103345-v555a2ll 110 3 comparison comparison NN cord-103345-v555a2ll 110 4 of of IN cord-103345-v555a2ll 110 5 all all DT cord-103345-v555a2ll 110 6 transport transport NN cord-103345-v555a2ll 110 7 velocities velocity NNS cord-103345-v555a2ll 110 8 ( ( -LRB- cord-103345-v555a2ll 110 9 Fig Fig NNP cord-103345-v555a2ll 110 10 . . . cord-103345-v555a2ll 110 11 _SP cord-103345-v555a2ll 110 12 5E 5E NNP cord-103345-v555a2ll 110 13 ) ) -RRB- cord-103345-v555a2ll 110 14 showed show VBD cord-103345-v555a2ll 110 15 a a DT cord-103345-v555a2ll 110 16 general general JJ cord-103345-v555a2ll 110 17 order order NN cord-103345-v555a2ll 110 18 of of IN cord-103345-v555a2ll 110 19 contributions contribution NNS cord-103345-v555a2ll 110 20 , , , cord-103345-v555a2ll 110 21 from from IN cord-103345-v555a2ll 110 22 the the DT cord-103345-v555a2ll 110 23 high high JJ cord-103345-v555a2ll 110 24 affinity affinity NN cord-103345-v555a2ll 110 25 CTL1 CTL1 NNP cord-103345-v555a2ll 110 26 ( ( -LRB- cord-103345-v555a2ll 110 27 Ctrl ctrl NN cord-103345-v555a2ll 110 28 + + CC cord-103345-v555a2ll 110 29 CTL2 CTL2 NNP cord-103345-v555a2ll 110 30 siRNA siRNA NNP cord-103345-v555a2ll 110 31 ) ) -RRB- cord-103345-v555a2ll 110 32 , , , cord-103345-v555a2ll 110 33 low low JJ cord-103345-v555a2ll 110 34 affinity affinity NN cord-103345-v555a2ll 110 35 CTL2 CTL2 NNP cord-103345-v555a2ll 110 36 ( ( -LRB- cord-103345-v555a2ll 110 37 M2 M2 NNP cord-103345-v555a2ll 110 38 ) ) -RRB- cord-103345-v555a2ll 110 39 , , , cord-103345-v555a2ll 110 40 and and CC cord-103345-v555a2ll 110 41 the the DT cord-103345-v555a2ll 110 42 residual residual JJ cord-103345-v555a2ll 110 43 very very RB cord-103345-v555a2ll 110 44 low low JJ cord-103345-v555a2ll 110 45 affinity affinity NN cord-103345-v555a2ll 110 46 ( ( -LRB- cord-103345-v555a2ll 110 47 M2+CTL2 M2+CTL2 NNP cord-103345-v555a2ll 110 48 siRNA siRNA NNP cord-103345-v555a2ll 110 49 ) ) -RRB- cord-103345-v555a2ll 110 50 transports transport VBZ cord-103345-v555a2ll 110 51 for for IN cord-103345-v555a2ll 110 52 Etn Etn NNP cord-103345-v555a2ll 110 53 . . . cord-103345-v555a2ll 110 54 CTL1(Ctrl CTL1(Ctrl NNP cord-103345-v555a2ll 110 55 ) ) -RRB- cord-103345-v555a2ll 110 56 contributed contribute VBD cord-103345-v555a2ll 110 57 80 80 CD cord-103345-v555a2ll 110 58 % % NN cord-103345-v555a2ll 110 59 , , , cord-103345-v555a2ll 110 60 CTL2 CTL2 NNP cord-103345-v555a2ll 110 61 ( ( -LRB- cord-103345-v555a2ll 110 62 M2 M2 NNP cord-103345-v555a2ll 110 63 ) ) -RRB- cord-103345-v555a2ll 110 64 12.5 12.5 CD cord-103345-v555a2ll 110 65 % % NN cord-103345-v555a2ll 110 66 , , , cord-103345-v555a2ll 110 67 and and CC cord-103345-v555a2ll 110 68 the the DT cord-103345-v555a2ll 110 69 unrelated unrelated JJ cord-103345-v555a2ll 110 70 residual residual JJ cord-103345-v555a2ll 110 71 transport transport NN cord-103345-v555a2ll 110 72 ( ( -LRB- cord-103345-v555a2ll 110 73 M2 M2 NNP cord-103345-v555a2ll 110 74 + + CC cord-103345-v555a2ll 110 75 CTL2 CTL2 NNP cord-103345-v555a2ll 110 76 siRNA siRNA NNP cord-103345-v555a2ll 110 77 ) ) -RRB- cord-103345-v555a2ll 110 78 accounted account VBD cord-103345-v555a2ll 110 79 for for IN cord-103345-v555a2ll 110 80 7.5 7.5 CD cord-103345-v555a2ll 110 81 % % NN cord-103345-v555a2ll 110 82 to to IN cord-103345-v555a2ll 110 83 the the DT cord-103345-v555a2ll 110 84 total total JJ cord-103345-v555a2ll 110 85 transport transport NN cord-103345-v555a2ll 110 86 . . . cord-103345-v555a2ll 111 1 The the DT cord-103345-v555a2ll 111 2 Ctrl ctrl NN cord-103345-v555a2ll 111 3 and and CC cord-103345-v555a2ll 111 4 M2 M2 NNP cord-103345-v555a2ll 111 5 cells cell NNS cord-103345-v555a2ll 111 6 express express VBP cord-103345-v555a2ll 111 7 OCT OCT NNP cord-103345-v555a2ll 111 8 and and CC cord-103345-v555a2ll 111 9 OCTN OCTN NNP cord-103345-v555a2ll 111 10 and and CC cord-103345-v555a2ll 111 11 other other JJ cord-103345-v555a2ll 111 12 unspecific unspecific JJ cord-103345-v555a2ll 111 13 Cho Cho NNP cord-103345-v555a2ll 111 14 transporters transporter NNS cord-103345-v555a2ll 111 15 that that WDT cord-103345-v555a2ll 111 16 could could MD cord-103345-v555a2ll 111 17 be be VB cord-103345-v555a2ll 111 18 contributing contribute VBG cord-103345-v555a2ll 111 19 to to IN cord-103345-v555a2ll 111 20 this this DT cord-103345-v555a2ll 111 21 residual residual JJ cord-103345-v555a2ll 111 22 transport transport NN cord-103345-v555a2ll 111 23 ( ( -LRB- cord-103345-v555a2ll 111 24 15 15 CD cord-103345-v555a2ll 111 25 ) ) -RRB- cord-103345-v555a2ll 111 26 . . . cord-103345-v555a2ll 112 1 CTL1 CTL1 NNP cord-103345-v555a2ll 112 2 and and CC cord-103345-v555a2ll 112 3 CTL2 CTL2 NNP cord-103345-v555a2ll 112 4 mediate mediate VB cord-103345-v555a2ll 112 5 Etn etn IN cord-103345-v555a2ll 112 6 transport transport NN cord-103345-v555a2ll 112 7 to to IN cord-103345-v555a2ll 112 8 mitochondria mitochondrion NNS cord-103345-v555a2ll 112 9 . . . cord-103345-v555a2ll 113 1 CTL1 CTL1 NNP cord-103345-v555a2ll 113 2 and and CC cord-103345-v555a2ll 113 3 CTL2 CTL2 NNP cord-103345-v555a2ll 113 4 are be VBP cord-103345-v555a2ll 113 5 present present JJ cord-103345-v555a2ll 113 6 in in IN cord-103345-v555a2ll 113 7 the the DT cord-103345-v555a2ll 113 8 mitochondria mitochondrion NNS cord-103345-v555a2ll 113 9 and and CC cord-103345-v555a2ll 113 10 are be VBP cord-103345-v555a2ll 113 11 involved involve VBN cord-103345-v555a2ll 113 12 in in IN cord-103345-v555a2ll 113 13 mitochondrial mitochondrial JJ cord-103345-v555a2ll 113 14 Cho Cho NNP cord-103345-v555a2ll 113 15 transport transport NN cord-103345-v555a2ll 113 16 ( ( -LRB- cord-103345-v555a2ll 113 17 4 4 CD cord-103345-v555a2ll 113 18 , , , cord-103345-v555a2ll 113 19 5 5 CD cord-103345-v555a2ll 113 20 ) ) -RRB- cord-103345-v555a2ll 113 21 . . . cord-103345-v555a2ll 114 1 We -PRON- PRP cord-103345-v555a2ll 114 2 used use VBD cord-103345-v555a2ll 114 3 COXIV COXIV NNP cord-103345-v555a2ll 114 4 as as IN cord-103345-v555a2ll 114 5 a a DT cord-103345-v555a2ll 114 6 marker marker NN cord-103345-v555a2ll 114 7 of of IN cord-103345-v555a2ll 114 8 mitochondria mitochondrion NNS cord-103345-v555a2ll 114 9 isolated isolate VBN cord-103345-v555a2ll 114 10 from from IN cord-103345-v555a2ll 114 11 Ctrl ctrl NN cord-103345-v555a2ll 114 12 and and CC cord-103345-v555a2ll 114 13 M2 m2 NN cord-103345-v555a2ll 114 14 cells cell NNS cord-103345-v555a2ll 114 15 and and CC cord-103345-v555a2ll 114 16 CTL2 CTL2 NNP cord-103345-v555a2ll 114 17 mRNA mrna NN cord-103345-v555a2ll 114 18 expression expression NN cord-103345-v555a2ll 114 19 for for IN cord-103345-v555a2ll 114 20 the the DT cord-103345-v555a2ll 114 21 siRNA siRNA NNP cord-103345-v555a2ll 114 22 knockdown knockdown NN cord-103345-v555a2ll 114 23 of of IN cord-103345-v555a2ll 114 24 CTL2 CTL2 NNP cord-103345-v555a2ll 114 25 transport transport NN cord-103345-v555a2ll 114 26 ( ( -LRB- cord-103345-v555a2ll 114 27 Fig fig NN cord-103345-v555a2ll 114 28 . . . cord-103345-v555a2ll 114 29 6A 6a CD cord-103345-v555a2ll 114 30 ) ) -RRB- cord-103345-v555a2ll 114 31 . . . cord-103345-v555a2ll 115 1 By by IN cord-103345-v555a2ll 115 2 comparing compare VBG cord-103345-v555a2ll 115 3 the the DT cord-103345-v555a2ll 115 4 contributions contribution NNS cord-103345-v555a2ll 115 5 of of IN cord-103345-v555a2ll 115 6 all all DT cord-103345-v555a2ll 115 7 mitochondria mitochondrion NNS cord-103345-v555a2ll 115 8 transport transport NN cord-103345-v555a2ll 115 9 components component NNS cord-103345-v555a2ll 115 10 ( ( -LRB- cord-103345-v555a2ll 115 11 Fig Fig NNP cord-103345-v555a2ll 115 12 . . . cord-103345-v555a2ll 115 13 6B 6b CD cord-103345-v555a2ll 115 14 ) ) -RRB- cord-103345-v555a2ll 115 15 , , , cord-103345-v555a2ll 115 16 CTL1+CTL2 CTL1+CTL2 NNP cord-103345-v555a2ll 115 17 ( ( -LRB- cord-103345-v555a2ll 115 18 Ctrl ctrl NN cord-103345-v555a2ll 115 19 ) ) -RRB- cord-103345-v555a2ll 115 20 contributed contribute VBD cord-103345-v555a2ll 115 21 70 70 CD cord-103345-v555a2ll 115 22 % % NN cord-103345-v555a2ll 115 23 , , , cord-103345-v555a2ll 115 24 CTL2 CTL2 NNP cord-103345-v555a2ll 115 25 ( ( -LRB- cord-103345-v555a2ll 115 26 M2 M2 NNP cord-103345-v555a2ll 115 27 ) ) -RRB- cord-103345-v555a2ll 115 28 20 20 CD cord-103345-v555a2ll 115 29 % % NN cord-103345-v555a2ll 115 30 , , , cord-103345-v555a2ll 115 31 and and CC cord-103345-v555a2ll 115 32 the the DT cord-103345-v555a2ll 115 33 residual residual JJ cord-103345-v555a2ll 115 34 unrelated unrelated JJ cord-103345-v555a2ll 115 35 transport transport NN cord-103345-v555a2ll 115 36 ( ( -LRB- cord-103345-v555a2ll 115 37 M2 M2 NNP cord-103345-v555a2ll 115 38 + + CC cord-103345-v555a2ll 115 39 CTL2 CTL2 NNP cord-103345-v555a2ll 115 40 siRNA siRNA NNP cord-103345-v555a2ll 115 41 ) ) -RRB- cord-103345-v555a2ll 115 42 contributed contribute VBD cord-103345-v555a2ll 115 43 10 10 CD cord-103345-v555a2ll 115 44 % % NN cord-103345-v555a2ll 115 45 to to IN cord-103345-v555a2ll 115 46 the the DT cord-103345-v555a2ll 115 47 total total JJ cord-103345-v555a2ll 115 48 mitochondria mitochondrion NNS cord-103345-v555a2ll 116 1 Etn etn IN cord-103345-v555a2ll 116 2 transport transport NN cord-103345-v555a2ll 116 3 . . . cord-103345-v555a2ll 117 1 We -PRON- PRP cord-103345-v555a2ll 117 2 also also RB cord-103345-v555a2ll 117 3 compared compare VBD cord-103345-v555a2ll 117 4 the the DT cord-103345-v555a2ll 117 5 rates rate NNS cord-103345-v555a2ll 117 6 of of IN cord-103345-v555a2ll 117 7 [ [ -LRB- cord-103345-v555a2ll 117 8 14 14 CD cord-103345-v555a2ll 117 9 C]-Etn c]-etn NN cord-103345-v555a2ll 117 10 transport transport NN cord-103345-v555a2ll 117 11 in in IN cord-103345-v555a2ll 117 12 the the DT cord-103345-v555a2ll 117 13 isolated isolated JJ cord-103345-v555a2ll 117 14 mitochondria mitochondrion NNS cord-103345-v555a2ll 117 15 and and CC cord-103345-v555a2ll 117 16 the the DT cord-103345-v555a2ll 117 17 whole whole JJ cord-103345-v555a2ll 117 18 cells cell NNS cord-103345-v555a2ll 117 19 and and CC cord-103345-v555a2ll 117 20 in in IN cord-103345-v555a2ll 117 21 the the DT cord-103345-v555a2ll 117 22 presence presence NN cord-103345-v555a2ll 117 23 and and CC cord-103345-v555a2ll 117 24 absence absence NN cord-103345-v555a2ll 117 25 of of IN cord-103345-v555a2ll 117 26 the the DT cord-103345-v555a2ll 117 27 specific specific JJ cord-103345-v555a2ll 117 28 inhibitor inhibitor NN cord-103345-v555a2ll 117 29 HC-3 HC-3 NNP cord-103345-v555a2ll 117 30 . . . cord-103345-v555a2ll 118 1 As as IN cord-103345-v555a2ll 118 2 expected expect VBN cord-103345-v555a2ll 118 3 , , , cord-103345-v555a2ll 118 4 the the DT cord-103345-v555a2ll 118 5 CTL1 CTL1 NNP cord-103345-v555a2ll 118 6 and and CC cord-103345-v555a2ll 118 7 CTL2 CTL2 NNP cord-103345-v555a2ll 118 8 inhibitor inhibitor NN cord-103345-v555a2ll 118 9 HC-3 HC-3 NNP cord-103345-v555a2ll 118 10 blunted blunt VBD cord-103345-v555a2ll 119 1 Etn etn IN cord-103345-v555a2ll 119 2 uptake uptake NN cord-103345-v555a2ll 119 3 in in IN cord-103345-v555a2ll 119 4 a a DT cord-103345-v555a2ll 119 5 time time NN cord-103345-v555a2ll 119 6 dependent dependent JJ cord-103345-v555a2ll 119 7 manner manner NN cord-103345-v555a2ll 119 8 in in IN cord-103345-v555a2ll 119 9 the the DT cord-103345-v555a2ll 119 10 mitochondria mitochondrion NNS cord-103345-v555a2ll 119 11 ( ( -LRB- cord-103345-v555a2ll 119 12 Fig Fig NNP cord-103345-v555a2ll 119 13 . . . cord-103345-v555a2ll 119 14 _SP cord-103345-v555a2ll 119 15 6C 6c NN cord-103345-v555a2ll 119 16 , , , cord-103345-v555a2ll 119 17 E E NNP cord-103345-v555a2ll 119 18 ) ) -RRB- cord-103345-v555a2ll 119 19 and and CC cord-103345-v555a2ll 119 20 the the DT cord-103345-v555a2ll 119 21 whole whole JJ cord-103345-v555a2ll 119 22 cells cell NNS cord-103345-v555a2ll 119 23 ( ( -LRB- cord-103345-v555a2ll 119 24 Fig fig NN cord-103345-v555a2ll 119 25 . . . cord-103345-v555a2ll 119 26 6 6 CD cord-103345-v555a2ll 119 27 D d NN cord-103345-v555a2ll 119 28 , , , cord-103345-v555a2ll 119 29 F F NNP cord-103345-v555a2ll 119 30 ) ) -RRB- cord-103345-v555a2ll 119 31 . . . cord-103345-v555a2ll 120 1 In in IN cord-103345-v555a2ll 120 2 the the DT cord-103345-v555a2ll 120 3 absence absence NN cord-103345-v555a2ll 120 4 of of IN cord-103345-v555a2ll 120 5 HC-3 HC-3 NNP cord-103345-v555a2ll 120 6 , , , cord-103345-v555a2ll 120 7 the the DT cord-103345-v555a2ll 120 8 rate rate NN cord-103345-v555a2ll 120 9 of of IN cord-103345-v555a2ll 120 10 Ctrl ctrl NN cord-103345-v555a2ll 120 11 mitochondria mitochondrion NNS cord-103345-v555a2ll 120 12 transport transport NN cord-103345-v555a2ll 120 13 was be VBD cord-103345-v555a2ll 120 14 similar similar JJ cord-103345-v555a2ll 120 15 to to IN cord-103345-v555a2ll 120 16 the the DT cord-103345-v555a2ll 120 17 whole whole JJ cord-103345-v555a2ll 120 18 cell cell NN cord-103345-v555a2ll 120 19 Ctrl ctrl NN cord-103345-v555a2ll 120 20 transport transport NN cord-103345-v555a2ll 120 21 ( ( -LRB- cord-103345-v555a2ll 120 22 0.04 0.04 CD cord-103345-v555a2ll 120 23 and and CC cord-103345-v555a2ll 120 24 0.05 0.05 CD cord-103345-v555a2ll 120 25 µmol µmol NNP cord-103345-v555a2ll 120 26 / / SYM cord-103345-v555a2ll 120 27 mg mg NNP cord-103345-v555a2ll 120 28 / / SYM cord-103345-v555a2ll 120 29 min min NNP cord-103345-v555a2ll 120 30 , , , cord-103345-v555a2ll 120 31 respectively respectively RB cord-103345-v555a2ll 120 32 ) ) -RRB- cord-103345-v555a2ll 120 33 ; ; : cord-103345-v555a2ll 120 34 M2 m2 JJ cord-103345-v555a2ll 120 35 mitochondrial mitochondrial JJ cord-103345-v555a2ll 120 36 transport transport NN cord-103345-v555a2ll 120 37 was be VBD cord-103345-v555a2ll 120 38 also also RB cord-103345-v555a2ll 120 39 similar similar JJ cord-103345-v555a2ll 120 40 to to IN cord-103345-v555a2ll 120 41 the the DT cord-103345-v555a2ll 120 42 whole whole JJ cord-103345-v555a2ll 120 43 cell cell NN cord-103345-v555a2ll 120 44 transport transport NN cord-103345-v555a2ll 120 45 ( ( -LRB- cord-103345-v555a2ll 120 46 0.008 0.008 CD cord-103345-v555a2ll 120 47 and and CC cord-103345-v555a2ll 120 48 0.01 0.01 CD cord-103345-v555a2ll 120 49 µmol µmol NNP cord-103345-v555a2ll 120 50 / / SYM cord-103345-v555a2ll 120 51 mg mg NNP cord-103345-v555a2ll 120 52 / / SYM cord-103345-v555a2ll 120 53 min min NNP cord-103345-v555a2ll 120 54 respectively respectively RB cord-103345-v555a2ll 120 55 ) ) -RRB- cord-103345-v555a2ll 120 56 ( ( -LRB- cord-103345-v555a2ll 121 1 Fig Fig NNP cord-103345-v555a2ll 121 2 . . . cord-103345-v555a2ll 122 1 6E 6E NNP cord-103345-v555a2ll 122 2 , , , cord-103345-v555a2ll 122 3 F F NNP cord-103345-v555a2ll 122 4 ) ) -RRB- cord-103345-v555a2ll 122 5 , , , cord-103345-v555a2ll 122 6 demonstrating demonstrate VBG cord-103345-v555a2ll 122 7 that that IN cord-103345-v555a2ll 122 8 the the DT cord-103345-v555a2ll 122 9 same same JJ cord-103345-v555a2ll 122 10 proteins protein NNS cord-103345-v555a2ll 122 11 are be VBP cord-103345-v555a2ll 122 12 responsible responsible JJ cord-103345-v555a2ll 122 13 for for IN cord-103345-v555a2ll 122 14 the the DT cord-103345-v555a2ll 122 15 transports transport NNS cord-103345-v555a2ll 122 16 in in IN cord-103345-v555a2ll 122 17 the the DT cord-103345-v555a2ll 122 18 whole whole JJ cord-103345-v555a2ll 122 19 cell cell NN cord-103345-v555a2ll 122 20 and and CC cord-103345-v555a2ll 122 21 mitochondria mitochondrion NNS cord-103345-v555a2ll 122 22 . . . cord-103345-v555a2ll 123 1 In in IN cord-103345-v555a2ll 123 2 addition addition NN cord-103345-v555a2ll 123 3 , , , cord-103345-v555a2ll 123 4 the the DT cord-103345-v555a2ll 123 5 M2 M2 NNP cord-103345-v555a2ll 123 6 mitochondrial mitochondrial NN cord-103345-v555a2ll 123 7 ( ( -LRB- cord-103345-v555a2ll 123 8 CTL2 CTL2 NNP cord-103345-v555a2ll 123 9 only only RB cord-103345-v555a2ll 123 10 ) ) -RRB- cord-103345-v555a2ll 123 11 transport transport NN cord-103345-v555a2ll 123 12 was be VBD cord-103345-v555a2ll 123 13 5-fold 5-fold CD cord-103345-v555a2ll 123 14 slower slow JJR cord-103345-v555a2ll 123 15 that that IN cord-103345-v555a2ll 123 16 the the DT cord-103345-v555a2ll 123 17 total total NN cord-103345-v555a2ll 123 18 ( ( -LRB- cord-103345-v555a2ll 123 19 CTL1+CTL2 CTL1+CTL2 NNP cord-103345-v555a2ll 123 20 ) ) -RRB- cord-103345-v555a2ll 123 21 transport transport NN cord-103345-v555a2ll 123 22 of of IN cord-103345-v555a2ll 123 23 the the DT cord-103345-v555a2ll 123 24 Ctrl ctrl NN cord-103345-v555a2ll 123 25 mitochondria mitochondrion NNS cord-103345-v555a2ll 123 26 . . . cord-103345-v555a2ll 124 1 Taken take VBN cord-103345-v555a2ll 124 2 together together RB cord-103345-v555a2ll 124 3 , , , cord-103345-v555a2ll 124 4 these these DT cord-103345-v555a2ll 124 5 data datum NNS cord-103345-v555a2ll 124 6 established establish VBD cord-103345-v555a2ll 124 7 that that IN cord-103345-v555a2ll 124 8 CTL1 CTL1 NNP cord-103345-v555a2ll 124 9 and and CC cord-103345-v555a2ll 124 10 CTL2 CTL2 NNP cord-103345-v555a2ll 124 11 mediate mediate VB cord-103345-v555a2ll 124 12 mitochondrial mitochondrial NN cord-103345-v555a2ll 125 1 Etn etn IN cord-103345-v555a2ll 125 2 transport transport NN cord-103345-v555a2ll 125 3 with with IN cord-103345-v555a2ll 125 4 the the DT cord-103345-v555a2ll 125 5 same same JJ cord-103345-v555a2ll 125 6 kinetic kinetic JJ cord-103345-v555a2ll 125 7 properties property NNS cord-103345-v555a2ll 125 8 as as IN cord-103345-v555a2ll 125 9 in in IN cord-103345-v555a2ll 125 10 the the DT cord-103345-v555a2ll 125 11 whole whole JJ cord-103345-v555a2ll 125 12 cells cell NNS cord-103345-v555a2ll 125 13 . . . cord-103345-v555a2ll 126 1 PE PE NNP cord-103345-v555a2ll 126 2 and and CC cord-103345-v555a2ll 126 3 PC PC NNP cord-103345-v555a2ll 126 4 are be VBP cord-103345-v555a2ll 126 5 bilayer bilayer JJ cord-103345-v555a2ll 126 6 forming form VBG cord-103345-v555a2ll 126 7 phospholipids phospholipid NNS cord-103345-v555a2ll 126 8 involved involve VBN cord-103345-v555a2ll 126 9 in in IN cord-103345-v555a2ll 126 10 fundamental fundamental JJ cord-103345-v555a2ll 126 11 membrane membrane NN cord-103345-v555a2ll 126 12 processes process NNS cord-103345-v555a2ll 126 13 , , , cord-103345-v555a2ll 126 14 growth growth NN cord-103345-v555a2ll 126 15 , , , cord-103345-v555a2ll 126 16 survival survival NN cord-103345-v555a2ll 126 17 and and CC cord-103345-v555a2ll 126 18 cell cell NN cord-103345-v555a2ll 126 19 signaling signaling NN cord-103345-v555a2ll 126 20 ( ( -LRB- cord-103345-v555a2ll 126 21 11 11 CD cord-103345-v555a2ll 126 22 ) ) -RRB- cord-103345-v555a2ll 126 23 . . . cord-103345-v555a2ll 127 1 PE PE NNP cord-103345-v555a2ll 127 2 and and CC cord-103345-v555a2ll 127 3 PC PC NNP cord-103345-v555a2ll 127 4 are be VBP cord-103345-v555a2ll 127 5 similarly similarly RB cord-103345-v555a2ll 127 6 synthesized synthesize VBN cord-103345-v555a2ll 127 7 by by IN cord-103345-v555a2ll 128 1 CDP CDP NNP cord-103345-v555a2ll 128 2 - - HYPH cord-103345-v555a2ll 128 3 Etn Etn NNP cord-103345-v555a2ll 128 4 and and CC cord-103345-v555a2ll 128 5 CDP CDP NNP cord-103345-v555a2ll 128 6 - - HYPH cord-103345-v555a2ll 128 7 Cho Cho NNP cord-103345-v555a2ll 128 8 Kennedy Kennedy NNP cord-103345-v555a2ll 128 9 pathway pathway NN cord-103345-v555a2ll 128 10 , , , cord-103345-v555a2ll 128 11 in in IN cord-103345-v555a2ll 128 12 which which WDT cord-103345-v555a2ll 128 13 the the DT cord-103345-v555a2ll 128 14 extracellular extracellular JJ cord-103345-v555a2ll 128 15 substrates substrate NNS cord-103345-v555a2ll 128 16 Cho Cho NNP cord-103345-v555a2ll 128 17 and and CC cord-103345-v555a2ll 128 18 Etn Etn NNP cord-103345-v555a2ll 128 19 are be VBP cord-103345-v555a2ll 128 20 actively actively RB cord-103345-v555a2ll 128 21 transported transport VBN cord-103345-v555a2ll 128 22 into into IN cord-103345-v555a2ll 128 23 the the DT cord-103345-v555a2ll 128 24 cell cell NN cord-103345-v555a2ll 128 25 , , , cord-103345-v555a2ll 128 26 phosphorylated phosphorylated JJ cord-103345-v555a2ll 128 27 , , , cord-103345-v555a2ll 128 28 and and CC cord-103345-v555a2ll 128 29 coupled couple VBN cord-103345-v555a2ll 128 30 with with IN cord-103345-v555a2ll 128 31 diacylglycerols diacylglycerol NNS cord-103345-v555a2ll 128 32 ( ( -LRB- cord-103345-v555a2ll 128 33 DAG DAG NNP cord-103345-v555a2ll 128 34 ) ) -RRB- cord-103345-v555a2ll 128 35 to to TO cord-103345-v555a2ll 128 36 form form VB cord-103345-v555a2ll 128 37 the the DT cord-103345-v555a2ll 128 38 final final JJ cord-103345-v555a2ll 128 39 phospholipid phospholipid NN cord-103345-v555a2ll 128 40 product product NN cord-103345-v555a2ll 128 41 . . . cord-103345-v555a2ll 129 1 Cho Cho NNP cord-103345-v555a2ll 129 2 and and CC cord-103345-v555a2ll 129 3 Etn Etn NNP cord-103345-v555a2ll 129 4 released release VBN cord-103345-v555a2ll 129 5 from from IN cord-103345-v555a2ll 129 6 PC PC NNP cord-103345-v555a2ll 129 7 and and CC cord-103345-v555a2ll 129 8 PE PE NNP cord-103345-v555a2ll 129 9 also also RB cord-103345-v555a2ll 129 10 need need VBP cord-103345-v555a2ll 129 11 to to TO cord-103345-v555a2ll 129 12 be be VB cord-103345-v555a2ll 129 13 transported transport VBN cord-103345-v555a2ll 129 14 in in IN cord-103345-v555a2ll 129 15 and and CC cord-103345-v555a2ll 129 16 out out IN cord-103345-v555a2ll 129 17 of of IN cord-103345-v555a2ll 129 18 the the DT cord-103345-v555a2ll 129 19 cytosol cytosol NN cord-103345-v555a2ll 129 20 and and CC cord-103345-v555a2ll 129 21 mitochondria mitochondrion NNS cord-103345-v555a2ll 129 22 or or CC cord-103345-v555a2ll 129 23 reincorporated reincorporate VBD cord-103345-v555a2ll 129 24 into into IN cord-103345-v555a2ll 129 25 the the DT cord-103345-v555a2ll 129 26 Kennedy Kennedy NNP cord-103345-v555a2ll 129 27 pathway pathway NN cord-103345-v555a2ll 129 28 . . . cord-103345-v555a2ll 130 1 The the DT cord-103345-v555a2ll 130 2 plasma plasma NN cord-103345-v555a2ll 130 3 membrane membrane NN cord-103345-v555a2ll 130 4 CTL1 CTL1 NNP cord-103345-v555a2ll 130 5 is be VBZ cord-103345-v555a2ll 130 6 firmly firmly RB cord-103345-v555a2ll 130 7 assigned assign VBN cord-103345-v555a2ll 130 8 to to IN cord-103345-v555a2ll 130 9 Cho Cho NNP cord-103345-v555a2ll 130 10 transport transport NN cord-103345-v555a2ll 130 11 for for IN cord-103345-v555a2ll 130 12 PC pc NN cord-103345-v555a2ll 130 13 synthesis synthesis NN cord-103345-v555a2ll 130 14 ( ( -LRB- cord-103345-v555a2ll 130 15 15 15 CD cord-103345-v555a2ll 130 16 ) ) -RRB- cord-103345-v555a2ll 130 17 , , , cord-103345-v555a2ll 130 18 yet yet CC cord-103345-v555a2ll 130 19 the the DT cord-103345-v555a2ll 130 20 exact exact JJ cord-103345-v555a2ll 130 21 function function NN cord-103345-v555a2ll 130 22 of of IN cord-103345-v555a2ll 130 23 the the DT cord-103345-v555a2ll 130 24 mitochondrial mitochondrial JJ cord-103345-v555a2ll 130 25 CTL1 CTL1 NNP cord-103345-v555a2ll 130 26 is be VBZ cord-103345-v555a2ll 130 27 still still RB cord-103345-v555a2ll 130 28 not not RB cord-103345-v555a2ll 130 29 clear clear JJ cord-103345-v555a2ll 130 30 . . . cord-103345-v555a2ll 131 1 In in IN cord-103345-v555a2ll 131 2 the the DT cord-103345-v555a2ll 131 3 liver liver NN cord-103345-v555a2ll 131 4 and and CC cord-103345-v555a2ll 131 5 kidney kidney NN cord-103345-v555a2ll 131 6 mitochondria mitochondrion NNS cord-103345-v555a2ll 131 7 , , , cord-103345-v555a2ll 131 8 Cho Cho NNP cord-103345-v555a2ll 131 9 is be VBZ cord-103345-v555a2ll 131 10 specifically specifically RB cord-103345-v555a2ll 131 11 oxidized oxidize VBN cord-103345-v555a2ll 131 12 to to IN cord-103345-v555a2ll 131 13 betaine betaine NN cord-103345-v555a2ll 131 14 , , , cord-103345-v555a2ll 131 15 the the DT cord-103345-v555a2ll 131 16 major major JJ cord-103345-v555a2ll 131 17 methyl methyl NN cord-103345-v555a2ll 131 18 donor donor NN cord-103345-v555a2ll 131 19 in in IN cord-103345-v555a2ll 131 20 the the DT cord-103345-v555a2ll 131 21 one one CD cord-103345-v555a2ll 131 22 - - HYPH cord-103345-v555a2ll 131 23 carbon carbon NN cord-103345-v555a2ll 131 24 cycle cycle NN cord-103345-v555a2ll 131 25 ( ( -LRB- cord-103345-v555a2ll 131 26 6 6 CD cord-103345-v555a2ll 131 27 ) ) -RRB- cord-103345-v555a2ll 131 28 . . . cord-103345-v555a2ll 132 1 Since since IN cord-103345-v555a2ll 132 2 broadly broadly RB cord-103345-v555a2ll 132 3 expressed express VBN cord-103345-v555a2ll 132 4 , , , cord-103345-v555a2ll 132 5 it -PRON- PRP cord-103345-v555a2ll 132 6 is be VBZ cord-103345-v555a2ll 132 7 proposed propose VBN cord-103345-v555a2ll 132 8 that that IN cord-103345-v555a2ll 132 9 the the DT cord-103345-v555a2ll 132 10 mitochondrial mitochondrial NN cord-103345-v555a2ll 132 11 CTL1 CTL1 NNP cord-103345-v555a2ll 132 12 could could MD cord-103345-v555a2ll 132 13 maintain maintain VB cord-103345-v555a2ll 132 14 the the DT cord-103345-v555a2ll 132 15 intracellular intracellular JJ cord-103345-v555a2ll 132 16 pools pool NNS cord-103345-v555a2ll 132 17 of of IN cord-103345-v555a2ll 132 18 Cho Cho NNP cord-103345-v555a2ll 132 19 and and CC cord-103345-v555a2ll 132 20 as as IN cord-103345-v555a2ll 132 21 + + CC cord-103345-v555a2ll 132 22 H h NN cord-103345-v555a2ll 132 23 - - HYPH cord-103345-v555a2ll 132 24 antiporter antiporter NNP cord-103345-v555a2ll 132 25 could could MD cord-103345-v555a2ll 132 26 regulate regulate VB cord-103345-v555a2ll 132 27 the the DT cord-103345-v555a2ll 132 28 electrochemical electrochemical JJ cord-103345-v555a2ll 132 29 / / SYM cord-103345-v555a2ll 132 30 proton proton NN cord-103345-v555a2ll 132 31 gradient gradient NN cord-103345-v555a2ll 132 32 in in IN cord-103345-v555a2ll 132 33 the the DT cord-103345-v555a2ll 132 34 mitochondria mitochondrion NNS cord-103345-v555a2ll 132 35 ( ( -LRB- cord-103345-v555a2ll 132 36 5 5 CD cord-103345-v555a2ll 132 37 , , , cord-103345-v555a2ll 132 38 15 15 CD cord-103345-v555a2ll 132 39 , , , cord-103345-v555a2ll 132 40 18 18 CD cord-103345-v555a2ll 132 41 ) ) -RRB- cord-103345-v555a2ll 132 42 . . . cord-103345-v555a2ll 133 1 CTL2 CTL2 NNP cord-103345-v555a2ll 133 2 is be VBZ cord-103345-v555a2ll 133 3 only only RB cord-103345-v555a2ll 133 4 indirectly indirectly RB cord-103345-v555a2ll 133 5 implicated implicate VBN cord-103345-v555a2ll 133 6 in in IN cord-103345-v555a2ll 133 7 Cho Cho NNP cord-103345-v555a2ll 133 8 transport transport NN cord-103345-v555a2ll 133 9 and and CC cord-103345-v555a2ll 133 10 until until IN cord-103345-v555a2ll 133 11 this this DT cord-103345-v555a2ll 133 12 work work NN cord-103345-v555a2ll 134 1 the the DT cord-103345-v555a2ll 134 2 exact exact JJ cord-103345-v555a2ll 134 3 CTL2 CTL2 NNP cord-103345-v555a2ll 134 4 substrate substrate NN cord-103345-v555a2ll 134 5 binding binding NN cord-103345-v555a2ll 134 6 and and CC cord-103345-v555a2ll 134 7 transport transport NN cord-103345-v555a2ll 134 8 mechanism mechanism NN cord-103345-v555a2ll 134 9 were be VBD cord-103345-v555a2ll 134 10 not not RB cord-103345-v555a2ll 134 11 firmly firmly RB cord-103345-v555a2ll 134 12 established establish VBN cord-103345-v555a2ll 134 13 , , , cord-103345-v555a2ll 134 14 in in IN cord-103345-v555a2ll 134 15 neither neither CC cord-103345-v555a2ll 134 16 the the DT cord-103345-v555a2ll 134 17 whole whole JJ cord-103345-v555a2ll 134 18 cells cell NNS cord-103345-v555a2ll 134 19 nor nor CC cord-103345-v555a2ll 134 20 isolated isolate VBN cord-103345-v555a2ll 134 21 mitochondria mitochondrion NNS cord-103345-v555a2ll 134 22 . . . cord-103345-v555a2ll 135 1 Based base VBN cord-103345-v555a2ll 135 2 on on IN cord-103345-v555a2ll 135 3 our -PRON- PRP$ cord-103345-v555a2ll 135 4 extensive extensive JJ cord-103345-v555a2ll 135 5 work work NN cord-103345-v555a2ll 135 6 on on IN cord-103345-v555a2ll 135 7 CTL1 CTL1 NNP cord-103345-v555a2ll 135 8 and and CC cord-103345-v555a2ll 135 9 Cho Cho NNP cord-103345-v555a2ll 135 10 transport transport NN cord-103345-v555a2ll 135 11 ( ( -LRB- cord-103345-v555a2ll 135 12 3 3 CD cord-103345-v555a2ll 135 13 ) ) -RRB- cord-103345-v555a2ll 135 14 ( ( -LRB- cord-103345-v555a2ll 135 15 4 4 LS cord-103345-v555a2ll 135 16 ) ) -RRB- cord-103345-v555a2ll 135 17 ( ( -LRB- cord-103345-v555a2ll 135 18 5 5 LS cord-103345-v555a2ll 135 19 ) ) -RRB- cord-103345-v555a2ll 135 20 ( ( -LRB- cord-103345-v555a2ll 135 21 6 6 LS cord-103345-v555a2ll 135 22 ) ) -RRB- cord-103345-v555a2ll 135 23 ( ( -LRB- cord-103345-v555a2ll 135 24 7 7 LS cord-103345-v555a2ll 135 25 ) ) -RRB- cord-103345-v555a2ll 135 26 ( ( -LRB- cord-103345-v555a2ll 135 27 8) 8) NNP cord-103345-v555a2ll 135 28 15 15 CD cord-103345-v555a2ll 135 29 ) ) -RRB- cord-103345-v555a2ll 135 30 and and CC cord-103345-v555a2ll 135 31 known know VBN cord-103345-v555a2ll 135 32 similarities similarity NNS cord-103345-v555a2ll 135 33 between between IN cord-103345-v555a2ll 135 34 Cho Cho NNP cord-103345-v555a2ll 135 35 and and CC cord-103345-v555a2ll 135 36 Etn Etn NNP cord-103345-v555a2ll 135 37 transports transport NNS cord-103345-v555a2ll 135 38 in in IN cord-103345-v555a2ll 135 39 various various JJ cord-103345-v555a2ll 135 40 conditions condition NNS cord-103345-v555a2ll 135 41 ( ( -LRB- cord-103345-v555a2ll 135 42 12 12 CD cord-103345-v555a2ll 135 43 ) ) -RRB- cord-103345-v555a2ll 135 44 ( ( -LRB- cord-103345-v555a2ll 135 45 13 13 CD cord-103345-v555a2ll 135 46 ) ) -RRB- cord-103345-v555a2ll 135 47 ( ( -LRB- cord-103345-v555a2ll 135 48 14 14 CD cord-103345-v555a2ll 135 49 ) ) -RRB- cord-103345-v555a2ll 135 50 we -PRON- PRP cord-103345-v555a2ll 135 51 postulated postulate VBD cord-103345-v555a2ll 135 52 that that IN cord-103345-v555a2ll 135 53 CTL1 CTL1 NNP cord-103345-v555a2ll 135 54 could could MD cord-103345-v555a2ll 135 55 be be VB cord-103345-v555a2ll 135 56 that that RB cord-103345-v555a2ll 135 57 long long RB cord-103345-v555a2ll 135 58 - - HYPH cord-103345-v555a2ll 135 59 searched search VBN cord-103345-v555a2ll 135 60 for for IN cord-103345-v555a2ll 135 61 Etn Etn NNP cord-103345-v555a2ll 135 62 / / SYM cord-103345-v555a2ll 135 63 Cho Cho NNP cord-103345-v555a2ll 135 64 transporter transporter NN cord-103345-v555a2ll 135 65 and and CC cord-103345-v555a2ll 135 66 the the DT cord-103345-v555a2ll 135 67 last last JJ cord-103345-v555a2ll 135 68 missing missing JJ cord-103345-v555a2ll 135 69 link link NN cord-103345-v555a2ll 135 70 between between IN cord-103345-v555a2ll 135 71 CDP CDP NNP cord-103345-v555a2ll 135 72 - - HYPH cord-103345-v555a2ll 135 73 Cho Cho NNP cord-103345-v555a2ll 135 74 and and CC cord-103345-v555a2ll 135 75 CDP CDP NNP cord-103345-v555a2ll 135 76 - - HYPH cord-103345-v555a2ll 135 77 Etn Etn NNP cord-103345-v555a2ll 135 78 pathways pathway NNS cord-103345-v555a2ll 135 79 for for IN cord-103345-v555a2ll 135 80 phospholipids phospholipid NNS cord-103345-v555a2ll 135 81 synthesis synthesis NN cord-103345-v555a2ll 135 82 . . . cord-103345-v555a2ll 136 1 We -PRON- PRP cord-103345-v555a2ll 136 2 conducted conduct VBD cord-103345-v555a2ll 136 3 an an DT cord-103345-v555a2ll 136 4 extensive extensive JJ cord-103345-v555a2ll 136 5 number number NN cord-103345-v555a2ll 136 6 of of IN cord-103345-v555a2ll 136 7 kinetic kinetic JJ cord-103345-v555a2ll 136 8 , , , cord-103345-v555a2ll 136 9 metabolic metabolic JJ cord-103345-v555a2ll 136 10 , , , cord-103345-v555a2ll 136 11 and and CC cord-103345-v555a2ll 136 12 genetic genetic JJ cord-103345-v555a2ll 136 13 experiments experiment NNS cord-103345-v555a2ll 136 14 to to TO cord-103345-v555a2ll 136 15 solidify solidify VB cord-103345-v555a2ll 136 16 this this DT cord-103345-v555a2ll 136 17 hypothesis hypothesis NN cord-103345-v555a2ll 136 18 . . . cord-103345-v555a2ll 137 1 We -PRON- PRP cord-103345-v555a2ll 137 2 established establish VBD cord-103345-v555a2ll 137 3 that that IN cord-103345-v555a2ll 137 4 CTL1 CTL1 NNP cord-103345-v555a2ll 137 5 mediated mediate VBD cord-103345-v555a2ll 137 6 a a DT cord-103345-v555a2ll 137 7 high high JJ cord-103345-v555a2ll 137 8 affinity affinity NN cord-103345-v555a2ll 138 1 Etn etn IN cord-103345-v555a2ll 138 2 transport transport NN cord-103345-v555a2ll 138 3 with with IN cord-103345-v555a2ll 138 4 K1 K1 NNP cord-103345-v555a2ll 138 5 = = SYM cord-103345-v555a2ll 138 6 56 56 CD cord-103345-v555a2ll 138 7 - - HYPH cord-103345-v555a2ll 138 8 67µM 67µm CD cord-103345-v555a2ll 139 1 and and CC cord-103345-v555a2ll 139 2 that that IN cord-103345-v555a2ll 139 3 CTL2 CTL2 NNP cord-103345-v555a2ll 139 4 mediated mediate VBD cord-103345-v555a2ll 139 5 a a DT cord-103345-v555a2ll 139 6 low low JJ cord-103345-v555a2ll 139 7 Etn Etn NNP cord-103345-v555a2ll 139 8 affinity affinity NN cord-103345-v555a2ll 139 9 transport transport NN cord-103345-v555a2ll 139 10 with with IN cord-103345-v555a2ll 139 11 K2 K2 NNP cord-103345-v555a2ll 139 12 = = NFP cord-103345-v555a2ll 140 1 275 275 CD cord-103345-v555a2ll 140 2 - - SYM cord-103345-v555a2ll 140 3 299 299 CD cord-103345-v555a2ll 140 4 µM µm NN cord-103345-v555a2ll 140 5 in in IN cord-103345-v555a2ll 140 6 primary primary JJ cord-103345-v555a2ll 140 7 human human JJ cord-103345-v555a2ll 140 8 fibroblasts fibroblast NNS cord-103345-v555a2ll 140 9 and and CC cord-103345-v555a2ll 140 10 monkey monkey NN cord-103345-v555a2ll 140 11 Cos7 Cos7 NNP cord-103345-v555a2ll 140 12 cells cell NNS cord-103345-v555a2ll 140 13 . . . cord-103345-v555a2ll 141 1 Importantly importantly RB cord-103345-v555a2ll 141 2 , , , cord-103345-v555a2ll 141 3 the the DT cord-103345-v555a2ll 141 4 CTL1 ctl1 JJ cord-103345-v555a2ll 141 5 affinity affinity NN cord-103345-v555a2ll 141 6 constant constant NN cord-103345-v555a2ll 141 7 for for IN cord-103345-v555a2ll 141 8 Etn Etn NNP cord-103345-v555a2ll 141 9 binding binding NN cord-103345-v555a2ll 141 10 is be VBZ cord-103345-v555a2ll 141 11 in in IN cord-103345-v555a2ll 141 12 the the DT cord-103345-v555a2ll 141 13 range range NN cord-103345-v555a2ll 141 14 of of IN cord-103345-v555a2ll 141 15 physiological physiological JJ cord-103345-v555a2ll 141 16 Etn Etn NNP cord-103345-v555a2ll 141 17 concentration concentration NN cord-103345-v555a2ll 141 18 in in IN cord-103345-v555a2ll 141 19 rat rat NN cord-103345-v555a2ll 141 20 and and CC cord-103345-v555a2ll 141 21 humans human NNS cord-103345-v555a2ll 141 22 ( ( -LRB- cord-103345-v555a2ll 141 23 10 10 CD cord-103345-v555a2ll 141 24 - - SYM cord-103345-v555a2ll 141 25 75µM 75µm CD cord-103345-v555a2ll 141 26 ) ) -RRB- cord-103345-v555a2ll 141 27 ( ( -LRB- cord-103345-v555a2ll 141 28 13 13 CD cord-103345-v555a2ll 141 29 ) ) -RRB- cord-103345-v555a2ll 141 30 , , , cord-103345-v555a2ll 141 31 and and CC cord-103345-v555a2ll 141 32 explains explain VBZ cord-103345-v555a2ll 141 33 why why WRB cord-103345-v555a2ll 141 34 CTL1 CTL1 NNP cord-103345-v555a2ll 141 35 contributed contribute VBD cord-103345-v555a2ll 141 36 the the DT cord-103345-v555a2ll 141 37 most most RBS cord-103345-v555a2ll 141 38 ( ( -LRB- cord-103345-v555a2ll 141 39 70 70 CD cord-103345-v555a2ll 141 40 - - SYM cord-103345-v555a2ll 141 41 80 80 CD cord-103345-v555a2ll 141 42 % % NN cord-103345-v555a2ll 141 43 ) ) -RRB- cord-103345-v555a2ll 141 44 of of IN cord-103345-v555a2ll 141 45 the the DT cord-103345-v555a2ll 141 46 Etn Etn NNP cord-103345-v555a2ll 141 47 transport transport NN cord-103345-v555a2ll 141 48 in in IN cord-103345-v555a2ll 141 49 the the DT cord-103345-v555a2ll 141 50 whole whole JJ cord-103345-v555a2ll 141 51 cells cell NNS cord-103345-v555a2ll 141 52 and and CC cord-103345-v555a2ll 141 53 mitochondria mitochondrion NNS cord-103345-v555a2ll 141 54 . . . cord-103345-v555a2ll 142 1 We -PRON- PRP cord-103345-v555a2ll 142 2 recently recently RB cord-103345-v555a2ll 142 3 described describe VBD cord-103345-v555a2ll 142 4 the the DT cord-103345-v555a2ll 142 5 first first JJ cord-103345-v555a2ll 142 6 human human JJ cord-103345-v555a2ll 142 7 disorder disorder NN cord-103345-v555a2ll 142 8 caused cause VBN cord-103345-v555a2ll 142 9 by by IN cord-103345-v555a2ll 142 10 homozygous homozygous JJ cord-103345-v555a2ll 142 11 frame frame JJ cord-103345-v555a2ll 142 12 - - HYPH cord-103345-v555a2ll 142 13 shift shift NN cord-103345-v555a2ll 142 14 mutations mutation NNS cord-103345-v555a2ll 142 15 in in IN cord-103345-v555a2ll 142 16 the the DT cord-103345-v555a2ll 142 17 CTL1 CTL1 NNP cord-103345-v555a2ll 142 18 gene gene NN cord-103345-v555a2ll 142 19 SLC44A1 slc44a1 NN cord-103345-v555a2ll 142 20 : : : cord-103345-v555a2ll 143 1 M1= M1= NNP cord-103345-v555a2ll 143 2 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 143 3 ΔAsp517 ΔAsp517 NNP cord-103345-v555a2ll 143 4 , , , cord-103345-v555a2ll 143 5 M2= M2= NNS cord-103345-v555a2ll 144 1 SLC44A1 SLC44A1 NNP cord-103345-v555a2ll 144 2 ΔSer126 ΔSer126 NNP cord-103345-v555a2ll 144 3 and and CC cord-103345-v555a2ll 144 4 M3= M3= NNP cord-103345-v555a2ll 144 5 SLC44A1 slc44a1 VBP cord-103345-v555a2ll 145 1 ΔLys90 ΔLys90 NNP cord-103345-v555a2ll 145 2 ( ( -LRB- cord-103345-v555a2ll 145 3 15 15 CD cord-103345-v555a2ll 145 4 ) ) -RRB- cord-103345-v555a2ll 145 5 . . . cord-103345-v555a2ll 146 1 After after IN cord-103345-v555a2ll 146 2 an an DT cord-103345-v555a2ll 146 3 extensive extensive JJ cord-103345-v555a2ll 146 4 characterization characterization NN cord-103345-v555a2ll 146 5 of of IN cord-103345-v555a2ll 146 6 transport transport NN cord-103345-v555a2ll 146 7 and and CC cord-103345-v555a2ll 146 8 metabolism metabolism NN cord-103345-v555a2ll 146 9 in in IN cord-103345-v555a2ll 146 10 patient patient NN cord-103345-v555a2ll 146 11 's 's POS cord-103345-v555a2ll 146 12 fibroblasts fibroblast NNS cord-103345-v555a2ll 146 13 it -PRON- PRP cord-103345-v555a2ll 146 14 was be VBD cord-103345-v555a2ll 146 15 apparent apparent JJ cord-103345-v555a2ll 146 16 that that IN cord-103345-v555a2ll 146 17 diminished diminish VBD cord-103345-v555a2ll 146 18 Cho Cho NNP cord-103345-v555a2ll 146 19 transport transport NN cord-103345-v555a2ll 146 20 is be VBZ cord-103345-v555a2ll 146 21 the the DT cord-103345-v555a2ll 146 22 primary primary JJ cord-103345-v555a2ll 146 23 cause cause NN cord-103345-v555a2ll 146 24 of of IN cord-103345-v555a2ll 146 25 this this DT cord-103345-v555a2ll 146 26 new new JJ cord-103345-v555a2ll 146 27 neurodegenerative neurodegenerative JJ cord-103345-v555a2ll 146 28 disorder disorder NN cord-103345-v555a2ll 146 29 with with IN cord-103345-v555a2ll 146 30 elements element NNS cord-103345-v555a2ll 146 31 of of IN cord-103345-v555a2ll 146 32 childhood childhood NN cord-103345-v555a2ll 146 33 - - HYPH cord-103345-v555a2ll 146 34 onset onset NN cord-103345-v555a2ll 146 35 parkinsonism parkinsonism NN cord-103345-v555a2ll 146 36 and and CC cord-103345-v555a2ll 146 37 MPAN MPAN NNP cord-103345-v555a2ll 146 38 ( ( -LRB- cord-103345-v555a2ll 146 39 mitochondrial mitochondrial JJ cord-103345-v555a2ll 146 40 membrane membrane NN cord-103345-v555a2ll 146 41 protein protein NN cord-103345-v555a2ll 146 42 - - HYPH cord-103345-v555a2ll 146 43 associated associate VBN cord-103345-v555a2ll 146 44 neurodegeneration)-like neurodegeneration)-like NNP cord-103345-v555a2ll 146 45 abnormalities abnormality NNS cord-103345-v555a2ll 146 46 . . . cord-103345-v555a2ll 147 1 Paradoxically paradoxically RB cord-103345-v555a2ll 147 2 , , , cord-103345-v555a2ll 147 3 although although IN cord-103345-v555a2ll 147 4 Cho Cho NNP cord-103345-v555a2ll 147 5 transport transport NN cord-103345-v555a2ll 147 6 and and CC cord-103345-v555a2ll 147 7 CDP CDP NNP cord-103345-v555a2ll 147 8 - - HYPH cord-103345-v555a2ll 147 9 Cho Cho NNP cord-103345-v555a2ll 147 10 Kennedy Kennedy NNP cord-103345-v555a2ll 147 11 pathway pathway NN cord-103345-v555a2ll 147 12 were be VBD cord-103345-v555a2ll 147 13 diminished diminish VBN cord-103345-v555a2ll 147 14 , , , cord-103345-v555a2ll 147 15 PC PC NNP cord-103345-v555a2ll 147 16 remained remain VBD cord-103345-v555a2ll 147 17 preserved preserve VBN cord-103345-v555a2ll 147 18 in in IN cord-103345-v555a2ll 147 19 the the DT cord-103345-v555a2ll 147 20 cerebrospinal cerebrospinal JJ cord-103345-v555a2ll 147 21 fluid fluid NN cord-103345-v555a2ll 147 22 and and CC cord-103345-v555a2ll 147 23 skin skin NN cord-103345-v555a2ll 147 24 fibroblasts fibroblast NNS cord-103345-v555a2ll 147 25 of of IN cord-103345-v555a2ll 147 26 the the DT cord-103345-v555a2ll 147 27 affected affect VBN cord-103345-v555a2ll 147 28 individuals individual NNS cord-103345-v555a2ll 147 29 ( ( -LRB- cord-103345-v555a2ll 147 30 15 15 CD cord-103345-v555a2ll 147 31 ) ) -RRB- cord-103345-v555a2ll 147 32 . . . cord-103345-v555a2ll 148 1 The the DT cord-103345-v555a2ll 148 2 cell cell NN cord-103345-v555a2ll 148 3 membranes membrane NNS cord-103345-v555a2ll 148 4 were be VBD cord-103345-v555a2ll 148 5 however however RB cord-103345-v555a2ll 148 6 drastically drastically RB cord-103345-v555a2ll 148 7 remodeled remodel VBN cord-103345-v555a2ll 148 8 and and CC cord-103345-v555a2ll 148 9 depleted deplete VBN cord-103345-v555a2ll 148 10 of of IN cord-103345-v555a2ll 148 11 PE PE NNP cord-103345-v555a2ll 148 12 and and CC cord-103345-v555a2ll 148 13 PS PS NNP cord-103345-v555a2ll 148 14 , , , cord-103345-v555a2ll 148 15 apparently apparently RB cord-103345-v555a2ll 148 16 as as IN cord-103345-v555a2ll 148 17 a a DT cord-103345-v555a2ll 148 18 homeostatic homeostatic JJ cord-103345-v555a2ll 148 19 response response NN cord-103345-v555a2ll 148 20 to to TO cord-103345-v555a2ll 148 21 preserve preserve VB cord-103345-v555a2ll 148 22 PC pc NN cord-103345-v555a2ll 148 23 and and CC cord-103345-v555a2ll 148 24 prevent prevent VB cord-103345-v555a2ll 148 25 Cho Cho NNP cord-103345-v555a2ll 148 26 deficiency deficiency NN cord-103345-v555a2ll 148 27 in in IN cord-103345-v555a2ll 148 28 the the DT cord-103345-v555a2ll 148 29 affected affect VBN cord-103345-v555a2ll 148 30 individuals individual NNS cord-103345-v555a2ll 148 31 ( ( -LRB- cord-103345-v555a2ll 148 32 15 15 CD cord-103345-v555a2ll 148 33 ) ) -RRB- cord-103345-v555a2ll 148 34 . . . cord-103345-v555a2ll 149 1 could could MD cord-103345-v555a2ll 149 2 maintain maintain VB cord-103345-v555a2ll 149 3 the the DT cord-103345-v555a2ll 149 4 intracellular intracellular JJ cord-103345-v555a2ll 149 5 pools pool NNS cord-103345-v555a2ll 149 6 of of IN cord-103345-v555a2ll 149 7 Cho Cho NNP cord-103345-v555a2ll 149 8 and and CC cord-103345-v555a2ll 149 9 Etn Etn NNP cord-103345-v555a2ll 149 10 and and CC cord-103345-v555a2ll 149 11 since since IN cord-103345-v555a2ll 149 12 they -PRON- PRP cord-103345-v555a2ll 149 13 are be VBP cord-103345-v555a2ll 149 14 both both DT cord-103345-v555a2ll 149 15 proton proton NN cord-103345-v555a2ll 149 16 antiporters antiporter NNS cord-103345-v555a2ll 149 17 , , , cord-103345-v555a2ll 149 18 they -PRON- PRP cord-103345-v555a2ll 149 19 could could MD cord-103345-v555a2ll 149 20 be be VB cord-103345-v555a2ll 149 21 significant significant JJ cord-103345-v555a2ll 149 22 regulators regulator NNS cord-103345-v555a2ll 149 23 of of IN cord-103345-v555a2ll 149 24 the the DT cord-103345-v555a2ll 149 25 proton proton NN cord-103345-v555a2ll 149 26 gradient gradient NN cord-103345-v555a2ll 149 27 in in IN cord-103345-v555a2ll 149 28 the the DT cord-103345-v555a2ll 149 29 mitochondria mitochondrion NNS cord-103345-v555a2ll 149 30 . . . cord-103345-v555a2ll 150 1 Recent recent JJ cord-103345-v555a2ll 150 2 studies study NNS cord-103345-v555a2ll 150 3 in in IN cord-103345-v555a2ll 150 4 CTL2 CTL2 NNP cord-103345-v555a2ll 150 5 knockout knockout NN cord-103345-v555a2ll 150 6 mice mouse NNS cord-103345-v555a2ll 150 7 established establish VBD cord-103345-v555a2ll 150 8 that that IN cord-103345-v555a2ll 150 9 that that IN cord-103345-v555a2ll 150 10 CTL2 CTL2 NNP cord-103345-v555a2ll 150 11 mediated mediate VBD cord-103345-v555a2ll 150 12 mitochondrial mitochondrial NN cord-103345-v555a2ll 150 13 Cho Cho NNP cord-103345-v555a2ll 150 14 transport transport NN cord-103345-v555a2ll 150 15 is be VBZ cord-103345-v555a2ll 150 16 critical critical JJ cord-103345-v555a2ll 150 17 for for IN cord-103345-v555a2ll 150 18 ATP ATP NNP cord-103345-v555a2ll 150 19 and and CC cord-103345-v555a2ll 150 20 ROS ROS NNP cord-103345-v555a2ll 150 21 production production NN cord-103345-v555a2ll 150 22 , , , cord-103345-v555a2ll 150 23 platelet platelet NN cord-103345-v555a2ll 150 24 activation activation NN cord-103345-v555a2ll 150 25 and and CC cord-103345-v555a2ll 150 26 thrombosis thrombosis NN cord-103345-v555a2ll 150 27 ( ( -LRB- cord-103345-v555a2ll 150 28 31 31 CD cord-103345-v555a2ll 150 29 ) ) -RRB- cord-103345-v555a2ll 150 30 . . . cord-103345-v555a2ll 151 1 CTL2 CTL2 NNP cord-103345-v555a2ll 151 2 gene gene NN cord-103345-v555a2ll 151 3 SLC44A2 SLC44A2 NNP cord-103345-v555a2ll 151 4 is be VBZ cord-103345-v555a2ll 151 5 well well RB cord-103345-v555a2ll 151 6 - - HYPH cord-103345-v555a2ll 151 7 established establish VBN cord-103345-v555a2ll 151 8 the the DT cord-103345-v555a2ll 151 9 human human JJ cord-103345-v555a2ll 151 10 neutrophil neutrophil NN cord-103345-v555a2ll 151 11 antigen antigen NN cord-103345-v555a2ll 151 12 ( ( -LRB- cord-103345-v555a2ll 151 13 32 32 CD cord-103345-v555a2ll 151 14 ) ) -RRB- cord-103345-v555a2ll 151 15 , , , cord-103345-v555a2ll 151 16 and and CC cord-103345-v555a2ll 151 17 genetic genetic JJ cord-103345-v555a2ll 151 18 risk risk NN cord-103345-v555a2ll 151 19 factor factor NN cord-103345-v555a2ll 151 20 for for IN cord-103345-v555a2ll 151 21 hearing hear VBG cord-103345-v555a2ll 151 22 loss loss NN cord-103345-v555a2ll 151 23 , , , cord-103345-v555a2ll 151 24 Meniere Meniere NNP cord-103345-v555a2ll 151 25 's 's POS cord-103345-v555a2ll 151 26 disease disease NN cord-103345-v555a2ll 151 27 and and CC cord-103345-v555a2ll 151 28 venous venous JJ cord-103345-v555a2ll 151 29 thrombosis thrombosis NN cord-103345-v555a2ll 151 30 ( ( -LRB- cord-103345-v555a2ll 151 31 33 33 CD cord-103345-v555a2ll 151 32 ) ) -RRB- cord-103345-v555a2ll 151 33 . . . cord-103345-v555a2ll 152 1 Neutrophil Neutrophil NNP cord-103345-v555a2ll 152 2 CTL2 CTL2 NNP cord-103345-v555a2ll 152 3 could could MD cord-103345-v555a2ll 152 4 interact interact VB cord-103345-v555a2ll 152 5 directly directly RB cord-103345-v555a2ll 152 6 with with IN cord-103345-v555a2ll 152 7 platelets platelet NNS cord-103345-v555a2ll 152 8 ' ' POS cord-103345-v555a2ll 152 9 integrin integrin NN cord-103345-v555a2ll 152 10 αIIbβ3 αiibβ3 NN cord-103345-v555a2ll 152 11 , , , cord-103345-v555a2ll 152 12 and and CC cord-103345-v555a2ll 152 13 induce induce VB cord-103345-v555a2ll 152 14 neutrophil neutrophil NN cord-103345-v555a2ll 152 15 extracellular extracellular JJ cord-103345-v555a2ll 152 16 trap trap NN cord-103345-v555a2ll 152 17 ( ( -LRB- cord-103345-v555a2ll 152 18 NETosis NETosis NNP cord-103345-v555a2ll 152 19 ) ) -RRB- cord-103345-v555a2ll 152 20 that that IN cord-103345-v555a2ll 152 21 than than IN cord-103345-v555a2ll 152 22 promote promote VB cord-103345-v555a2ll 152 23 thrombosis thrombosis NN cord-103345-v555a2ll 152 24 ( ( -LRB- cord-103345-v555a2ll 152 25 34 34 CD cord-103345-v555a2ll 152 26 ) ) -RRB- cord-103345-v555a2ll 152 27 . . . cord-103345-v555a2ll 153 1 In in IN cord-103345-v555a2ll 153 2 studies study NNS cord-103345-v555a2ll 153 3 with with IN cord-103345-v555a2ll 153 4 CTL1 CTL1 NNP cord-103345-v555a2ll 153 5 and and CC cord-103345-v555a2ll 153 6 CTL2 CTL2 NNP cord-103345-v555a2ll 153 7 antibodies antibody NNS cord-103345-v555a2ll 153 8 8.0 8.0 CD cord-103345-v555a2ll 153 9 x x SYM cord-103345-v555a2ll 153 10 10 10 CD cord-103345-v555a2ll 153 11 4 4 CD cord-103345-v555a2ll 153 12 cells cell NNS cord-103345-v555a2ll 153 13 / / SYM cord-103345-v555a2ll 153 14 well well RB cord-103345-v555a2ll 153 15 were be VBD cord-103345-v555a2ll 153 16 seeded seed VBN cord-103345-v555a2ll 153 17 in in IN cord-103345-v555a2ll 153 18 6-well 6-well CD cord-103345-v555a2ll 153 19 plates plate NNS cord-103345-v555a2ll 153 20 and and CC cord-103345-v555a2ll 153 21 grown grow VBN cord-103345-v555a2ll 153 22 for for IN cord-103345-v555a2ll 153 23 24h 24h NNS cord-103345-v555a2ll 153 24 . . . cord-103345-v555a2ll 154 1 After after IN cord-103345-v555a2ll 154 2 24h 24h NNS cord-103345-v555a2ll 154 3 of of IN cord-103345-v555a2ll 154 4 growth growth NN cord-103345-v555a2ll 154 5 , , , cord-103345-v555a2ll 154 6 various various JJ cord-103345-v555a2ll 154 7 amounts amount NNS cord-103345-v555a2ll 154 8 of of IN cord-103345-v555a2ll 154 9 antibodies antibody NNS cord-103345-v555a2ll 154 10 were be VBD cord-103345-v555a2ll 154 11 added add VBN cord-103345-v555a2ll 154 12 to to IN cord-103345-v555a2ll 154 13 cells cell NNS cord-103345-v555a2ll 154 14 and and CC cord-103345-v555a2ll 154 15 incubated incubate VBN cord-103345-v555a2ll 154 16 for for IN cord-103345-v555a2ll 154 17 24h 24h NNS cord-103345-v555a2ll 154 18 and and CC cord-103345-v555a2ll 154 19 Cho Cho NNP cord-103345-v555a2ll 154 20 and and CC cord-103345-v555a2ll 154 21 Etn Etn NNP cord-103345-v555a2ll 154 22 uptake uptake NN cord-103345-v555a2ll 154 23 were be VBD cord-103345-v555a2ll 154 24 then then RB cord-103345-v555a2ll 154 25 conducted conduct VBN cord-103345-v555a2ll 154 26 . . . cord-103345-v555a2ll 155 1 radiolabeling radiolabele VBG cord-103345-v555a2ll 155 2 with with IN cord-103345-v555a2ll 155 3 3H 3h CD cord-103345-v555a2ll 155 4 - - HYPH cord-103345-v555a2ll 155 5 glycerol glycerol NN cord-103345-v555a2ll 155 6 as as IN cord-103345-v555a2ll 155 7 previously previously RB cord-103345-v555a2ll 155 8 described describe VBN cord-103345-v555a2ll 155 9 ( ( -LRB- cord-103345-v555a2ll 155 10 40 40 CD cord-103345-v555a2ll 155 11 ) ) -RRB- cord-103345-v555a2ll 155 12 . . . cord-103345-v555a2ll 156 1 Pcyt2 Pcyt2 NNP cord-103345-v555a2ll 156 2 Activity Activity NNP cord-103345-v555a2ll 156 3 Assay Assay NNP cord-103345-v555a2ll 156 4 . . . cord-103345-v555a2ll 157 1 The the DT cord-103345-v555a2ll 157 2 assay assay NN cord-103345-v555a2ll 157 3 was be VBD cord-103345-v555a2ll 157 4 conducted conduct VBN cord-103345-v555a2ll 157 5 as as IN cord-103345-v555a2ll 157 6 described describe VBN cord-103345-v555a2ll 157 7 ( ( -LRB- cord-103345-v555a2ll 157 8 40 40 CD cord-103345-v555a2ll 157 9 PSD PSD NNP cord-103345-v555a2ll 157 10 , , , cord-103345-v555a2ll 157 11 PSS1 PSS1 NNP cord-103345-v555a2ll 157 12 and and CC cord-103345-v555a2ll 157 13 PSS2 PSS2 NNP cord-103345-v555a2ll 157 14 was be VBD cord-103345-v555a2ll 157 15 determined determine VBN cord-103345-v555a2ll 157 16 by by IN cord-103345-v555a2ll 157 17 PCR PCR NNP cord-103345-v555a2ll 157 18 using use VBG cord-103345-v555a2ll 157 19 the the DT cord-103345-v555a2ll 157 20 primers primer NNS cord-103345-v555a2ll 157 21 and and CC cord-103345-v555a2ll 157 22 conditions condition NNS cord-103345-v555a2ll 157 23 as as IN cord-103345-v555a2ll 157 24 before before RB cord-103345-v555a2ll 157 25 ( ( -LRB- cord-103345-v555a2ll 157 26 15 15 CD cord-103345-v555a2ll 157 27 ) ) -RRB- cord-103345-v555a2ll 157 28 . . . cord-103345-v555a2ll 158 1 Reactions reaction NNS cord-103345-v555a2ll 158 2 were be VBD cord-103345-v555a2ll 158 3 standardized standardize VBN cord-103345-v555a2ll 158 4 by by IN cord-103345-v555a2ll 158 5 amplifying amplify VBG cord-103345-v555a2ll 158 6 glyceraldehyde glyceraldehyde NN cord-103345-v555a2ll 158 7 3-phosphate 3-phosphate CD cord-103345-v555a2ll 158 8 dehydrogenase dehydrogenase NN cord-103345-v555a2ll 158 9 ( ( -LRB- cord-103345-v555a2ll 158 10 GAPDH GAPDH NNP cord-103345-v555a2ll 158 11 ) ) -RRB- cord-103345-v555a2ll 158 12 and and CC cord-103345-v555a2ll 158 13 relative relative JJ cord-103345-v555a2ll 158 14 band band NN cord-103345-v555a2ll 158 15 intensity intensity NN cord-103345-v555a2ll 158 16 was be VBD cord-103345-v555a2ll 158 17 quantified quantify VBN cord-103345-v555a2ll 158 18 using use VBG cord-103345-v555a2ll 158 19 ImageJ imagej DT cord-103345-v555a2ll 158 20 software software NN cord-103345-v555a2ll 158 21 ( ( -LRB- cord-103345-v555a2ll 158 22 NIH NIH NNP cord-103345-v555a2ll 158 23 , , , cord-103345-v555a2ll 158 24 Bethesda Bethesda NNP cord-103345-v555a2ll 158 25 , , , cord-103345-v555a2ll 158 26 MD MD NNP cord-103345-v555a2ll 158 27 , , , cord-103345-v555a2ll 158 28 USA USA NNP cord-103345-v555a2ll 158 29 ) ) -RRB- cord-103345-v555a2ll 158 30 . . . cord-103345-v555a2ll 159 1 Mitochondrial mitochondrial JJ cord-103345-v555a2ll 159 2 Isolation Isolation NNP cord-103345-v555a2ll 159 3 . . . cord-103345-v555a2ll 160 1 Mitochondria mitochondrion NNS cord-103345-v555a2ll 160 2 were be VBD cord-103345-v555a2ll 160 3 isolated isolate VBN cord-103345-v555a2ll 160 4 as as IN cord-103345-v555a2ll 160 5 initially initially RB cord-103345-v555a2ll 160 6 described describe VBN cord-103345-v555a2ll 160 7 ( ( -LRB- cord-103345-v555a2ll 160 8 18 18 CD cord-103345-v555a2ll 160 9 ) ) -RRB- cord-103345-v555a2ll 160 10 . . . cord-103345-v555a2ll 161 1 In in IN cord-103345-v555a2ll 161 2 brief brief NN cord-103345-v555a2ll 161 3 , , , cord-103345-v555a2ll 161 4 cells cell NNS cord-103345-v555a2ll 161 5 were be VBD cord-103345-v555a2ll 161 6 incubated incubate VBN cord-103345-v555a2ll 161 7 for for IN cord-103345-v555a2ll 161 8 20 20 CD cord-103345-v555a2ll 161 9 minutes minute NNS cord-103345-v555a2ll 161 10 in in IN cord-103345-v555a2ll 161 11 ice ice NN cord-103345-v555a2ll 161 12 - - HYPH cord-103345-v555a2ll 161 13 cold cold JJ cord-103345-v555a2ll 161 14 RSB RSB NNP cord-103345-v555a2ll 161 15 swelling swell VBG cord-103345-v555a2ll 161 16 buffer buffer NN cord-103345-v555a2ll 161 17 and and CC cord-103345-v555a2ll 161 18 homogenized homogenize VBN cord-103345-v555a2ll 161 19 ; ; : cord-103345-v555a2ll 161 20 19 19 CD cord-103345-v555a2ll 161 21 ml ml NN cord-103345-v555a2ll 161 22 MS MS NNP cord-103345-v555a2ll 161 23 buffer buffer NN cord-103345-v555a2ll 161 24 was be VBD cord-103345-v555a2ll 161 25 added add VBN cord-103345-v555a2ll 161 26 , , , cord-103345-v555a2ll 161 27 and and CC cord-103345-v555a2ll 161 28 the the DT cord-103345-v555a2ll 161 29 cell cell NN cord-103345-v555a2ll 161 30 homogenate homogenate NNP cord-103345-v555a2ll 161 31 was be VBD cord-103345-v555a2ll 161 32 centrifuged centrifuge VBN cord-103345-v555a2ll 161 33 at at IN cord-103345-v555a2ll 161 34 2500 2500 CD cord-103345-v555a2ll 161 35 rpm rpm NN cord-103345-v555a2ll 161 36 for for IN cord-103345-v555a2ll 161 37 5 5 CD cord-103345-v555a2ll 161 38 minutes minute NNS cord-103345-v555a2ll 161 39 . . . cord-103345-v555a2ll 162 1 This this DT cord-103345-v555a2ll 162 2 step step NN cord-103345-v555a2ll 162 3 was be VBD cord-103345-v555a2ll 162 4 repeated repeat VBN cord-103345-v555a2ll 162 5 twice twice RB cord-103345-v555a2ll 162 6 , , , cord-103345-v555a2ll 162 7 and and CC cord-103345-v555a2ll 162 8 the the DT cord-103345-v555a2ll 162 9 final final JJ cord-103345-v555a2ll 162 10 supernatant supernatant NN cord-103345-v555a2ll 162 11 was be VBD cord-103345-v555a2ll 162 12 centrifuged centrifuge VBN cord-103345-v555a2ll 162 13 at at IN cord-103345-v555a2ll 162 14 12,500 12,500 CD cord-103345-v555a2ll 162 15 rpm rpm NN cord-103345-v555a2ll 162 16 . . . cord-103345-v555a2ll 163 1 The the DT cord-103345-v555a2ll 163 2 resulting result VBG cord-103345-v555a2ll 163 3 pellet pellet NN cord-103345-v555a2ll 163 4 was be VBD cord-103345-v555a2ll 163 5 resuspended resuspend VBN cord-103345-v555a2ll 163 6 in in IN cord-103345-v555a2ll 163 7 MS MS NNP cord-103345-v555a2ll 163 8 buffer buffer NN cord-103345-v555a2ll 163 9 . . . cord-103345-v555a2ll 164 1 The the DT cord-103345-v555a2ll 164 2 mitochondria mitochondrion NNS cord-103345-v555a2ll 164 3 purity purity NN cord-103345-v555a2ll 164 4 was be VBD cord-103345-v555a2ll 164 5 determined determine VBN cord-103345-v555a2ll 164 6 using use VBG cord-103345-v555a2ll 164 7 COXIV COXIV NNP cord-103345-v555a2ll 164 8 mitochondria mitochondrion NNS cord-103345-v555a2ll 164 9 marked mark VBN cord-103345-v555a2ll 164 10 and and CC cord-103345-v555a2ll 164 11 β β NN cord-103345-v555a2ll 164 12 - - HYPH cord-103345-v555a2ll 164 13 tubulin tubulin NN cord-103345-v555a2ll 164 14 as as IN cord-103345-v555a2ll 164 15 a a DT cord-103345-v555a2ll 164 16 whole whole JJ cord-103345-v555a2ll 164 17 cell cell NN cord-103345-v555a2ll 164 18 control control NN cord-103345-v555a2ll 164 19 . . . cord-103345-v555a2ll 165 1 Statistical Statistical NNP cord-103345-v555a2ll 165 2 Analysis Analysis NNP cord-103345-v555a2ll 165 3 . . . cord-103345-v555a2ll 166 1 All all DT cord-103345-v555a2ll 166 2 measurements measurement NNS cord-103345-v555a2ll 166 3 are be VBP cord-103345-v555a2ll 166 4 expressed express VBN cord-103345-v555a2ll 166 5 as as IN cord-103345-v555a2ll 166 6 means mean NNS cord-103345-v555a2ll 166 7 from from IN cord-103345-v555a2ll 166 8 quadruplets quadruplet NNS cord-103345-v555a2ll 166 9 ± ± NNP cord-103345-v555a2ll 166 10 SEM SEM NNP cord-103345-v555a2ll 166 11 . . . cord-103345-v555a2ll 167 1 Statistical statistical JJ cord-103345-v555a2ll 167 2 analysis analysis NN cord-103345-v555a2ll 167 3 was be VBD cord-103345-v555a2ll 167 4 performed perform VBN cord-103345-v555a2ll 167 5 using use VBG cord-103345-v555a2ll 167 6 GraphPad GraphPad NNP cord-103345-v555a2ll 167 7 Prism Prism NNP cord-103345-v555a2ll 167 8 software software NN cord-103345-v555a2ll 167 9 ( ( -LRB- cord-103345-v555a2ll 167 10 GraphPad GraphPad NNP cord-103345-v555a2ll 167 11 , , , cord-103345-v555a2ll 167 12 Inc. Inc. NNP cord-103345-v555a2ll 167 13 ) ) -RRB- cord-103345-v555a2ll 167 14 . . . cord-103345-v555a2ll 168 1 Data datum NNS cord-103345-v555a2ll 168 2 were be VBD cord-103345-v555a2ll 168 3 subjected subject VBN cord-103345-v555a2ll 168 4 to to IN cord-103345-v555a2ll 168 5 students student NNS cord-103345-v555a2ll 168 6 T t NN cord-103345-v555a2ll 168 7 - - HYPH cord-103345-v555a2ll 168 8 test test NN cord-103345-v555a2ll 168 9 . . . cord-103345-v555a2ll 169 1 Differences difference NNS cord-103345-v555a2ll 169 2 were be VBD cord-103345-v555a2ll 169 3 considered consider VBN cord-103345-v555a2ll 169 4 statistically statistically RB cord-103345-v555a2ll 169 5 significant significant JJ cord-103345-v555a2ll 169 6 at at IN cord-103345-v555a2ll 169 7 * * NFP cord-103345-v555a2ll 169 8 p p XX cord-103345-v555a2ll 169 9 < < XX cord-103345-v555a2ll 169 10 0.05 0.05 CD cord-103345-v555a2ll 169 11 . . . cord-103345-v555a2ll 170 1 All all DT cord-103345-v555a2ll 170 2 study study NN cord-103345-v555a2ll 170 3 data datum NNS cord-103345-v555a2ll 170 4 are be VBP cord-103345-v555a2ll 170 5 included include VBN cord-103345-v555a2ll 170 6 in in IN cord-103345-v555a2ll 170 7 the the DT cord-103345-v555a2ll 170 8 article article NN cord-103345-v555a2ll 170 9 _SP cord-103345-v555a2ll 170 10 analyzed analyze VBD cord-103345-v555a2ll 170 11 data datum NNS cord-103345-v555a2ll 170 12 and and CC cord-103345-v555a2ll 170 13 wrote write VBD cord-103345-v555a2ll 170 14 the the DT cord-103345-v555a2ll 170 15 paper paper NN cord-103345-v555a2ll 171 1 The the DT cord-103345-v555a2ll 171 2 relationship relationship NN cord-103345-v555a2ll 171 3 between between IN cord-103345-v555a2ll 171 4 phospholipids phospholipid NNS cord-103345-v555a2ll 171 5 and and CC cord-103345-v555a2ll 171 6 insulin insulin NN cord-103345-v555a2ll 171 7 resistance resistance NN cord-103345-v555a2ll 171 8 : : : cord-103345-v555a2ll 171 9 From from IN cord-103345-v555a2ll 171 10 clinical clinical JJ cord-103345-v555a2ll 171 11 to to IN cord-103345-v555a2ll 171 12 experimental experimental JJ cord-103345-v555a2ll 171 13 studies study NNS cord-103345-v555a2ll 171 14 Phosphatidylethanolamine Phosphatidylethanolamine NNP cord-103345-v555a2ll 171 15 deficiency deficiency NN cord-103345-v555a2ll 171 16 in in IN cord-103345-v555a2ll 171 17 mammalian mammalian JJ cord-103345-v555a2ll 171 18 mitochondria mitochondrion NNS cord-103345-v555a2ll 171 19 impairs impair VBZ cord-103345-v555a2ll 171 20 oxidative oxidative JJ cord-103345-v555a2ll 171 21 phosphorylation phosphorylation NN cord-103345-v555a2ll 171 22 and and CC cord-103345-v555a2ll 171 23 alters alter VBZ cord-103345-v555a2ll 171 24 mitochondrial mitochondrial JJ cord-103345-v555a2ll 171 25 morphology morphology NN cord-103345-v555a2ll 171 26 Choline choline NN cord-103345-v555a2ll 171 27 transport transport NN cord-103345-v555a2ll 171 28 for for IN cord-103345-v555a2ll 171 29 phospholipid phospholipid NN cord-103345-v555a2ll 171 30 synthesis synthesis NN cord-103345-v555a2ll 171 31 Choline choline NN cord-103345-v555a2ll 171 32 transport transport NN cord-103345-v555a2ll 171 33 for for IN cord-103345-v555a2ll 171 34 phospholipid phospholipid NN cord-103345-v555a2ll 171 35 synthesis synthesis NN cord-103345-v555a2ll 171 36 : : : cord-103345-v555a2ll 172 1 An an DT cord-103345-v555a2ll 172 2 emerging emerge VBG cord-103345-v555a2ll 172 3 role role NN cord-103345-v555a2ll 172 4 of of IN cord-103345-v555a2ll 172 5 choline choline NN cord-103345-v555a2ll 172 6 transporter transporter NN cord-103345-v555a2ll 172 7 - - HYPH cord-103345-v555a2ll 172 8 like like JJ cord-103345-v555a2ll 172 9 protein protein NN cord-103345-v555a2ll 172 10 1 1 CD cord-103345-v555a2ll 173 1 The the DT cord-103345-v555a2ll 173 2 solute solute NN cord-103345-v555a2ll 173 3 carrier carrier NN cord-103345-v555a2ll 173 4 44A1 44a1 CD cord-103345-v555a2ll 173 5 is be VBZ cord-103345-v555a2ll 173 6 a a DT cord-103345-v555a2ll 173 7 mitochondrial mitochondrial JJ cord-103345-v555a2ll 173 8 protein protein NN cord-103345-v555a2ll 173 9 and and CC cord-103345-v555a2ll 173 10 mediates mediate VBZ cord-103345-v555a2ll 173 11 choline choline NN cord-103345-v555a2ll 173 12 transport transport NN cord-103345-v555a2ll 173 13 Betaine betaine NN cord-103345-v555a2ll 173 14 and and CC cord-103345-v555a2ll 173 15 choline choline NN cord-103345-v555a2ll 173 16 improve improve VBP cord-103345-v555a2ll 173 17 lipid lipid NN cord-103345-v555a2ll 173 18 homeostasis homeostasis NN cord-103345-v555a2ll 173 19 in in IN cord-103345-v555a2ll 173 20 obesity obesity NN cord-103345-v555a2ll 173 21 by by IN cord-103345-v555a2ll 173 22 participation participation NN cord-103345-v555a2ll 173 23 in in IN cord-103345-v555a2ll 173 24 mitochondrial mitochondrial JJ cord-103345-v555a2ll 173 25 oxidative oxidative JJ cord-103345-v555a2ll 173 26 demethylation demethylation NN cord-103345-v555a2ll 173 27 Choline choline NN cord-103345-v555a2ll 173 28 supplementation supplementation NN cord-103345-v555a2ll 173 29 restores restore VBZ cord-103345-v555a2ll 173 30 substrate substrate NN cord-103345-v555a2ll 173 31 balance balance NN cord-103345-v555a2ll 173 32 and and CC cord-103345-v555a2ll 173 33 alleviates alleviate VBZ cord-103345-v555a2ll 173 34 complications complication NNS cord-103345-v555a2ll 173 35 of of IN cord-103345-v555a2ll 173 36 Pcyt2 pcyt2 JJ cord-103345-v555a2ll 173 37 deficiency deficiency NN cord-103345-v555a2ll 173 38 Palmitic palmitic JJ cord-103345-v555a2ll 173 39 acid acid NN cord-103345-v555a2ll 173 40 and and CC cord-103345-v555a2ll 173 41 oleic oleic JJ cord-103345-v555a2ll 173 42 acid acid NN cord-103345-v555a2ll 173 43 differentially differentially RB cord-103345-v555a2ll 173 44 regulate regulate VBP cord-103345-v555a2ll 173 45 choline choline NN cord-103345-v555a2ll 173 46 transporter transporter NN cord-103345-v555a2ll 173 47 - - HYPH cord-103345-v555a2ll 173 48 like like JJ cord-103345-v555a2ll 173 49 1 1 CD cord-103345-v555a2ll 173 50 levels level NNS cord-103345-v555a2ll 173 51 and and CC cord-103345-v555a2ll 173 52 glycerolipid glycerolipid NNP cord-103345-v555a2ll 173 53 metabolism metabolism NN cord-103345-v555a2ll 173 54 in in IN cord-103345-v555a2ll 173 55 skeletal skeletal JJ cord-103345-v555a2ll 173 56 muscle muscle NN cord-103345-v555a2ll 173 57 cells cell NNS cord-103345-v555a2ll 173 58 De De NNP cord-103345-v555a2ll 173 59 novo novo NN cord-103345-v555a2ll 173 60 synthesis synthesis NN cord-103345-v555a2ll 173 61 of of IN cord-103345-v555a2ll 173 62 phospholipids phospholipid NNS cord-103345-v555a2ll 173 63 is be VBZ cord-103345-v555a2ll 173 64 coupled couple VBN cord-103345-v555a2ll 173 65 with with IN cord-103345-v555a2ll 173 66 autophagosome autophagosome JJ cord-103345-v555a2ll 173 67 formation formation NN cord-103345-v555a2ll 173 68 Ethanolamine Ethanolamine NNP cord-103345-v555a2ll 173 69 and and CC cord-103345-v555a2ll 173 70 phosphatidylethanolamine phosphatidylethanolamine NN cord-103345-v555a2ll 173 71 : : : cord-103345-v555a2ll 173 72 partners partner NNS cord-103345-v555a2ll 173 73 in in IN cord-103345-v555a2ll 173 74 health health NN cord-103345-v555a2ll 173 75 and and CC cord-103345-v555a2ll 173 76 disease disease NN cord-103345-v555a2ll 173 77 Regulation Regulation NNP cord-103345-v555a2ll 173 78 of of IN cord-103345-v555a2ll 173 79 phosphatidylethanolamine phosphatidylethanolamine JJ cord-103345-v555a2ll 173 80 homeostasis homeostasis NN cord-103345-v555a2ll 173 81 -the -the ADD cord-103345-v555a2ll 173 82 critical critical JJ cord-103345-v555a2ll 173 83 role role NN cord-103345-v555a2ll 173 84 of of IN cord-103345-v555a2ll 173 85 CTP CTP NNP cord-103345-v555a2ll 173 86 : : : cord-103345-v555a2ll 173 87 phosphoethanolamine phosphoethanolamine NNP cord-103345-v555a2ll 173 88 cytidylyltransferase cytidylyltransferase NNP cord-103345-v555a2ll 173 89 ( ( -LRB- cord-103345-v555a2ll 174 1 Pcyt2 Pcyt2 NNP cord-103345-v555a2ll 174 2 ) ) -RRB- cord-103345-v555a2ll 174 3 Ethanolamine Ethanolamine NNP cord-103345-v555a2ll 174 4 and and CC cord-103345-v555a2ll 174 5 choline choline NN cord-103345-v555a2ll 174 6 transport transport NN cord-103345-v555a2ll 174 7 in in IN cord-103345-v555a2ll 174 8 cultured cultured JJ cord-103345-v555a2ll 174 9 bovine bovine JJ cord-103345-v555a2ll 174 10 aortic aortic JJ cord-103345-v555a2ll 174 11 endothelial endothelial JJ cord-103345-v555a2ll 174 12 cells cell NNS cord-103345-v555a2ll 174 13 Effect effect NN cord-103345-v555a2ll 174 14 of of IN cord-103345-v555a2ll 174 15 ethanolamine ethanolamine NN cord-103345-v555a2ll 174 16 on on IN cord-103345-v555a2ll 174 17 choline choline NN cord-103345-v555a2ll 174 18 uptake uptake NN cord-103345-v555a2ll 174 19 and and CC cord-103345-v555a2ll 174 20 incorporation incorporation NN cord-103345-v555a2ll 174 21 into into IN cord-103345-v555a2ll 174 22 phosphatidylcholine phosphatidylcholine NN cord-103345-v555a2ll 174 23 in in IN cord-103345-v555a2ll 174 24 cells cell NNS cord-103345-v555a2ll 174 25 . . . cord-103345-v555a2ll 175 1 human human JJ cord-103345-v555a2ll 175 2 Y79 Y79 NNP cord-103345-v555a2ll 175 3 retinoblastoma retinoblastoma NN cord-103345-v555a2ll 175 4 Uptake Uptake NNP cord-103345-v555a2ll 175 5 of of IN cord-103345-v555a2ll 175 6 ethanolamine ethanolamine NN cord-103345-v555a2ll 175 7 in in IN cord-103345-v555a2ll 175 8 neuronal neuronal JJ cord-103345-v555a2ll 175 9 and and CC cord-103345-v555a2ll 175 10 glial glial JJ cord-103345-v555a2ll 175 11 cell cell NN cord-103345-v555a2ll 175 12 cultures culture NNS cord-103345-v555a2ll 176 1 Choline choline NN cord-103345-v555a2ll 176 2 transporter transporter NN cord-103345-v555a2ll 176 3 - - HYPH cord-103345-v555a2ll 176 4 like like JJ cord-103345-v555a2ll 176 5 1 1 CD cord-103345-v555a2ll 176 6 deficiency deficiency NN cord-103345-v555a2ll 176 7 causes cause VBZ cord-103345-v555a2ll 176 8 a a DT cord-103345-v555a2ll 176 9 new new JJ cord-103345-v555a2ll 176 10 type type NN cord-103345-v555a2ll 176 11 of of IN cord-103345-v555a2ll 176 12 childhoodonset childhoodonset NN cord-103345-v555a2ll 176 13 neurodegeneration neurodegeneration NN cord-103345-v555a2ll 176 14 Isoform Isoform NNP cord-103345-v555a2ll 176 15 - - HYPH cord-103345-v555a2ll 176 16 specific specific JJ cord-103345-v555a2ll 176 17 and and CC cord-103345-v555a2ll 176 18 protein protein NN cord-103345-v555a2ll 176 19 kinase kinase NN cord-103345-v555a2ll 176 20 C c NN cord-103345-v555a2ll 176 21 - - HYPH cord-103345-v555a2ll 176 22 mediated mediate VBN cord-103345-v555a2ll 176 23 regulation regulation NN cord-103345-v555a2ll 176 24 of of IN cord-103345-v555a2ll 176 25 CTP CTP NNP cord-103345-v555a2ll 176 26 : : : cord-103345-v555a2ll 176 27 phosphoethanolamine phosphoethanolamine NNP cord-103345-v555a2ll 176 28 cytidylyltransferase cytidylyltransferase NN cord-103345-v555a2ll 176 29 phosphorylation phosphorylation NN cord-103345-v555a2ll 176 30 Stimulation stimulation NN cord-103345-v555a2ll 176 31 of of IN cord-103345-v555a2ll 176 32 the the DT cord-103345-v555a2ll 176 33 human human JJ cord-103345-v555a2ll 176 34 CTP CTP NNP cord-103345-v555a2ll 176 35 : : : cord-103345-v555a2ll 176 36 phosphoethanolamine phosphoethanolamine NNP cord-103345-v555a2ll 176 37 cytidylyltransferase cytidylyltransferase NNP cord-103345-v555a2ll 176 38 gene gene NN cord-103345-v555a2ll 176 39 by by IN cord-103345-v555a2ll 176 40 early early JJ cord-103345-v555a2ll 176 41 growth growth NN cord-103345-v555a2ll 176 42 response response NN cord-103345-v555a2ll 176 43 protein protein NN cord-103345-v555a2ll 176 44 1 1 CD cord-103345-v555a2ll 176 45 Mechanism Mechanism NNP cord-103345-v555a2ll 176 46 of of IN cord-103345-v555a2ll 176 47 choline choline NN cord-103345-v555a2ll 176 48 deficiency deficiency NN cord-103345-v555a2ll 176 49 and and CC cord-103345-v555a2ll 176 50 membrane membrane NN cord-103345-v555a2ll 176 51 alteration alteration NN cord-103345-v555a2ll 176 52 in in IN cord-103345-v555a2ll 176 53 postural postural JJ cord-103345-v555a2ll 176 54 orthostatic orthostatic JJ cord-103345-v555a2ll 176 55 tachycardia tachycardia NN cord-103345-v555a2ll 176 56 syndrome syndrome NN cord-103345-v555a2ll 176 57 primary primary JJ cord-103345-v555a2ll 176 58 skin skin NN cord-103345-v555a2ll 176 59 fibroblasts fibroblast VBZ cord-103345-v555a2ll 176 60 Functional functional JJ cord-103345-v555a2ll 176 61 expression expression NN cord-103345-v555a2ll 176 62 of of IN cord-103345-v555a2ll 176 63 choline choline NN cord-103345-v555a2ll 176 64 transporter transporter NN cord-103345-v555a2ll 176 65 like like IN cord-103345-v555a2ll 176 66 - - HYPH cord-103345-v555a2ll 176 67 protein protein NN cord-103345-v555a2ll 176 68 1 1 CD cord-103345-v555a2ll 176 69 ( ( -LRB- cord-103345-v555a2ll 176 70 CTL1 CTL1 NNP cord-103345-v555a2ll 176 71 ) ) -RRB- cord-103345-v555a2ll 176 72 and and CC cord-103345-v555a2ll 176 73 CTL2 CTL2 NNP cord-103345-v555a2ll 176 74 in in IN cord-103345-v555a2ll 176 75 human human JJ cord-103345-v555a2ll 176 76 brain brain NN cord-103345-v555a2ll 176 77 microvascular microvascular NN cord-103345-v555a2ll 176 78 endothelial endothelial JJ cord-103345-v555a2ll 176 79 cells cell NNS cord-103345-v555a2ll 176 80 Molecular molecular JJ cord-103345-v555a2ll 176 81 and and CC cord-103345-v555a2ll 176 82 functional functional JJ cord-103345-v555a2ll 176 83 characterization characterization NN cord-103345-v555a2ll 176 84 of of IN cord-103345-v555a2ll 176 85 choline choline NN cord-103345-v555a2ll 176 86 transporter transporter NN cord-103345-v555a2ll 176 87 in in IN cord-103345-v555a2ll 176 88 human human JJ cord-103345-v555a2ll 176 89 colon colon NN cord-103345-v555a2ll 176 90 carcinoma carcinoma NN cord-103345-v555a2ll 176 91 HT-29 HT-29 NNP cord-103345-v555a2ll 176 92 cells cell NNS cord-103345-v555a2ll 176 93 Molecular molecular JJ cord-103345-v555a2ll 176 94 and and CC cord-103345-v555a2ll 176 95 functional functional JJ cord-103345-v555a2ll 176 96 characterization characterization NN cord-103345-v555a2ll 176 97 of of IN cord-103345-v555a2ll 176 98 choline choline NN cord-103345-v555a2ll 176 99 transporter transporter NN cord-103345-v555a2ll 176 100 - - HYPH cord-103345-v555a2ll 176 101 like like JJ cord-103345-v555a2ll 176 102 proteins protein NNS cord-103345-v555a2ll 176 103 in in IN cord-103345-v555a2ll 176 104 esophageal esophageal JJ cord-103345-v555a2ll 176 105 cancer cancer NN cord-103345-v555a2ll 176 106 cells cell NNS cord-103345-v555a2ll 176 107 and and CC cord-103345-v555a2ll 176 108 potential potential JJ cord-103345-v555a2ll 176 109 therapeutic therapeutic JJ cord-103345-v555a2ll 176 110 targets target NNS cord-103345-v555a2ll 176 111 Identification identification NN cord-103345-v555a2ll 176 112 and and CC cord-103345-v555a2ll 176 113 functional functional JJ cord-103345-v555a2ll 176 114 analysis analysis NN cord-103345-v555a2ll 176 115 of of IN cord-103345-v555a2ll 176 116 choline choline NN cord-103345-v555a2ll 176 117 transporter transporter NN cord-103345-v555a2ll 176 118 in in IN cord-103345-v555a2ll 176 119 tongue tongue NN cord-103345-v555a2ll 176 120 cancer cancer NN cord-103345-v555a2ll 176 121 : : : cord-103345-v555a2ll 176 122 A a DT cord-103345-v555a2ll 176 123 novel novel JJ cord-103345-v555a2ll 176 124 molecular molecular JJ cord-103345-v555a2ll 176 125 target target NN cord-103345-v555a2ll 176 126 for for IN cord-103345-v555a2ll 176 127 tongue tongue NN cord-103345-v555a2ll 176 128 cancer cancer NN cord-103345-v555a2ll 176 129 therapy therapy NN cord-103345-v555a2ll 176 130 Ethanolamine Ethanolamine NNP cord-103345-v555a2ll 176 131 inhibits inhibit VBZ cord-103345-v555a2ll 176 132 choline choline NN cord-103345-v555a2ll 176 133 uptake uptake NN cord-103345-v555a2ll 176 134 in in IN cord-103345-v555a2ll 176 135 the the DT cord-103345-v555a2ll 176 136 isolated isolate VBN cord-103345-v555a2ll 176 137 hamster hamster NN cord-103345-v555a2ll 176 138 heart heart NN cord-103345-v555a2ll 176 139 Effects effect NNS cord-103345-v555a2ll 176 140 of of IN cord-103345-v555a2ll 176 141 amino amino NN cord-103345-v555a2ll 176 142 acids acid NNS cord-103345-v555a2ll 176 143 and and CC cord-103345-v555a2ll 176 144 Ethanolamine Ethanolamine NNP cord-103345-v555a2ll 176 145 on on IN cord-103345-v555a2ll 176 146 choline choline NN cord-103345-v555a2ll 176 147 uptake uptake NN cord-103345-v555a2ll 176 148 and and CC cord-103345-v555a2ll 176 149 phosphatidylcholine phosphatidylcholine NN cord-103345-v555a2ll 176 150 biosynthesis biosynthesis NN cord-103345-v555a2ll 176 151 in in IN cord-103345-v555a2ll 176 152 baby baby NN cord-103345-v555a2ll 176 153 hamster hamster NN cord-103345-v555a2ll 176 154 kidney-21 kidney-21 CC cord-103345-v555a2ll 176 155 cells cell VBZ cord-103345-v555a2ll 176 156 Functional functional JJ cord-103345-v555a2ll 176 157 analysis analysis NN cord-103345-v555a2ll 176 158 of of IN cord-103345-v555a2ll 176 159 [ [ -LRB- cord-103345-v555a2ll 176 160 methyl-(3)H]choline methyl-(3)h]choline JJ cord-103345-v555a2ll 176 161 uptake uptake NN cord-103345-v555a2ll 176 162 in in IN cord-103345-v555a2ll 176 163 glioblastoma glioblastoma NN cord-103345-v555a2ll 176 164 cells cell NNS cord-103345-v555a2ll 176 165 : : : cord-103345-v555a2ll 176 166 Influence influence NN cord-103345-v555a2ll 176 167 of of IN cord-103345-v555a2ll 176 168 anti anti JJ cord-103345-v555a2ll 176 169 - - JJ cord-103345-v555a2ll 176 170 cancer cancer JJ cord-103345-v555a2ll 176 171 and and CC cord-103345-v555a2ll 176 172 central central JJ cord-103345-v555a2ll 176 173 nervous nervous JJ cord-103345-v555a2ll 176 174 system system NN cord-103345-v555a2ll 176 175 drugs drug NNS cord-103345-v555a2ll 176 176 Ethanolamine Ethanolamine NNP cord-103345-v555a2ll 176 177 ameliorates ameliorate VBZ cord-103345-v555a2ll 176 178 mitochondrial mitochondrial JJ cord-103345-v555a2ll 176 179 dysfunction dysfunction NN cord-103345-v555a2ll 176 180 in in IN cord-103345-v555a2ll 176 181 cardiolipin cardiolipin NN cord-103345-v555a2ll 176 182 - - HYPH cord-103345-v555a2ll 176 183 deficient deficient JJ cord-103345-v555a2ll 176 184 yeast yeast NN cord-103345-v555a2ll 176 185 cells cell NNS cord-103345-v555a2ll 177 1 Ethanolamine Ethanolamine NNP cord-103345-v555a2ll 177 2 enhances enhance VBZ cord-103345-v555a2ll 177 3 the the DT cord-103345-v555a2ll 177 4 proliferation proliferation NN cord-103345-v555a2ll 177 5 of of IN cord-103345-v555a2ll 177 6 intestinal intestinal JJ cord-103345-v555a2ll 177 7 epithelial epithelial JJ cord-103345-v555a2ll 177 8 cells cell NNS cord-103345-v555a2ll 177 9 via via IN cord-103345-v555a2ll 177 10 the the DT cord-103345-v555a2ll 177 11 mTOR mTOR NNP cord-103345-v555a2ll 177 12 signaling signal VBG cord-103345-v555a2ll 177 13 pathway pathway NN cord-103345-v555a2ll 177 14 and and CC cord-103345-v555a2ll 177 15 mitochondrial mitochondrial NN cord-103345-v555a2ll 177 16 function function NN cord-103345-v555a2ll 177 17 Looking look VBG cord-103345-v555a2ll 177 18 Beyond Beyond NNP cord-103345-v555a2ll 177 19 Structure structure NN cord-103345-v555a2ll 177 20 : : : cord-103345-v555a2ll 177 21 Membrane membrane NN cord-103345-v555a2ll 177 22 Phospholipids phospholipid NNS cord-103345-v555a2ll 177 23 of of IN cord-103345-v555a2ll 177 24 Skeletal skeletal JJ cord-103345-v555a2ll 177 25 Muscle muscle NN cord-103345-v555a2ll 177 26 Mitochondria mitochondrion NNS cord-103345-v555a2ll 177 27 Cardiolipin Cardiolipin NNP cord-103345-v555a2ll 177 28 and and CC cord-103345-v555a2ll 177 29 mitochondrial mitochondrial JJ cord-103345-v555a2ll 177 30 cristae cristae NN cord-103345-v555a2ll 177 31 organization organization NN cord-103345-v555a2ll 177 32 Effects effect NNS cord-103345-v555a2ll 177 33 of of IN cord-103345-v555a2ll 177 34 lipids lipid NNS cord-103345-v555a2ll 177 35 on on IN cord-103345-v555a2ll 177 36 mitochondrial mitochondrial JJ cord-103345-v555a2ll 177 37 functions function NNS cord-103345-v555a2ll 178 1 The the DT cord-103345-v555a2ll 178 2 choline choline NN cord-103345-v555a2ll 178 3 transporter transporter NN cord-103345-v555a2ll 178 4 Slc44a2 Slc44a2 NNP cord-103345-v555a2ll 178 5 controls control VBZ cord-103345-v555a2ll 178 6 platelet platelet NN cord-103345-v555a2ll 178 7 activation activation NN cord-103345-v555a2ll 178 8 and and CC cord-103345-v555a2ll 178 9 thrombosis thrombosis NN cord-103345-v555a2ll 178 10 by by IN cord-103345-v555a2ll 178 11 regulating regulate VBG cord-103345-v555a2ll 178 12 mitochondrial mitochondrial JJ cord-103345-v555a2ll 178 13 function function NN cord-103345-v555a2ll 179 1 Molecular molecular JJ cord-103345-v555a2ll 179 2 genetics genetic NNS cord-103345-v555a2ll 179 3 of of IN cord-103345-v555a2ll 179 4 the the DT cord-103345-v555a2ll 179 5 human human JJ cord-103345-v555a2ll 179 6 neutrophil neutrophil NN cord-103345-v555a2ll 179 7 antigens antigen NNS cord-103345-v555a2ll 179 8 SLC44A2 slc44a2 JJ cord-103345-v555a2ll 179 9 single single JJ cord-103345-v555a2ll 179 10 nucleotide nucleotide JJ cord-103345-v555a2ll 179 11 polymorphisms polymorphism NNS cord-103345-v555a2ll 179 12 , , , cord-103345-v555a2ll 179 13 isoforms isoform NNS cord-103345-v555a2ll 179 14 , , , cord-103345-v555a2ll 179 15 and and CC cord-103345-v555a2ll 179 16 expression expression NN cord-103345-v555a2ll 179 17 : : : cord-103345-v555a2ll 179 18 Association association NN cord-103345-v555a2ll 179 19 with with IN cord-103345-v555a2ll 179 20 severity severity NN cord-103345-v555a2ll 179 21 of of IN cord-103345-v555a2ll 179 22 Meniere Meniere NNP cord-103345-v555a2ll 179 23 's 's POS cord-103345-v555a2ll 179 24 disease disease NN cord-103345-v555a2ll 179 25 ? ? . cord-103345-v555a2ll 180 1 Bercu Bercu NNP cord-103345-v555a2ll 180 2 Activated activate VBD cord-103345-v555a2ll 180 3 αIIbβ3 αIIbβ3 VBG cord-103345-v555a2ll 180 4 on on IN cord-103345-v555a2ll 180 5 platelets platelet NNS cord-103345-v555a2ll 180 6 mediates mediate VBZ cord-103345-v555a2ll 180 7 flow flow NN cord-103345-v555a2ll 180 8 - - HYPH cord-103345-v555a2ll 180 9 dependent dependent JJ cord-103345-v555a2ll 180 10 NETosis netosis NN cord-103345-v555a2ll 180 11 via via IN cord-103345-v555a2ll 180 12 SLC44A2 slc44a2 NN cord-103345-v555a2ll 180 13 . . . cord-103345-v555a2ll 181 1 Elife Elife NNP cord-103345-v555a2ll 181 2 Characterization characterization NN cord-103345-v555a2ll 181 3 of of IN cord-103345-v555a2ll 181 4 hemostasis hemostasis NN cord-103345-v555a2ll 181 5 in in IN cord-103345-v555a2ll 181 6 mice mouse NNS cord-103345-v555a2ll 181 7 lacking lack VBG cord-103345-v555a2ll 181 8 the the DT cord-103345-v555a2ll 181 9 novel novel JJ cord-103345-v555a2ll 181 10 thrombosis thrombosis NN cord-103345-v555a2ll 181 11 susceptibility susceptibility NN cord-103345-v555a2ll 181 12 gene gene NN cord-103345-v555a2ll 182 1 Slc44a2 Slc44a2 NNP cord-103345-v555a2ll 183 1 SLC44A2 slc44a2 JJ cord-103345-v555a2ll 184 1 deficient deficient JJ cord-103345-v555a2ll 184 2 mice mouse NNS cord-103345-v555a2ll 184 3 have have VBP cord-103345-v555a2ll 184 4 a a DT cord-103345-v555a2ll 184 5 reduced reduce VBN cord-103345-v555a2ll 184 6 response response NN cord-103345-v555a2ll 184 7 in in IN cord-103345-v555a2ll 184 8 stenosis stenosis NN cord-103345-v555a2ll 184 9 but but CC cord-103345-v555a2ll 184 10 not not RB cord-103345-v555a2ll 184 11 in in IN cord-103345-v555a2ll 184 12 hypercoagulability hypercoagulability NN cord-103345-v555a2ll 184 13 driven drive VBN cord-103345-v555a2ll 184 14 venous venous JJ cord-103345-v555a2ll 184 15 thrombosis thrombosis NN cord-103345-v555a2ll 184 16 SLC44A2-A slc44a2-a CD cord-103345-v555a2ll 184 17 novel novel NN cord-103345-v555a2ll 184 18 therapeutic therapeutic JJ cord-103345-v555a2ll 184 19 target target NN cord-103345-v555a2ll 184 20 for for IN cord-103345-v555a2ll 184 21 venous venous JJ cord-103345-v555a2ll 184 22 thrombosis thrombosis NN cord-103345-v555a2ll 184 23 ? ? . cord-103345-v555a2ll 185 1 Identification identification NN cord-103345-v555a2ll 185 2 and and CC cord-103345-v555a2ll 185 3 expression expression NN cord-103345-v555a2ll 185 4 of of IN cord-103345-v555a2ll 185 5 a a DT cord-103345-v555a2ll 185 6 mouse mouse NN cord-103345-v555a2ll 185 7 muscle muscle NN cord-103345-v555a2ll 185 8 - - HYPH cord-103345-v555a2ll 185 9 specific specific JJ cord-103345-v555a2ll 185 10 CTL1 CTL1 NNP cord-103345-v555a2ll 185 11 gene gene NN cord-103345-v555a2ll 186 1 A a DT cord-103345-v555a2ll 186 2 rapid rapid JJ cord-103345-v555a2ll 186 3 method method NN cord-103345-v555a2ll 186 4 of of IN cord-103345-v555a2ll 186 5 total total JJ cord-103345-v555a2ll 186 6 lipid lipid NN cord-103345-v555a2ll 186 7 extraction extraction NN cord-103345-v555a2ll 186 8 and and CC cord-103345-v555a2ll 186 9 purification purification NN cord-103345-v555a2ll 186 10 Developmental developmental JJ cord-103345-v555a2ll 186 11 and and CC cord-103345-v555a2ll 186 12 metabolic metabolic JJ cord-103345-v555a2ll 186 13 effects effect NNS cord-103345-v555a2ll 186 14 of of IN cord-103345-v555a2ll 186 15 disruption disruption NN cord-103345-v555a2ll 186 16 of of IN cord-103345-v555a2ll 186 17 the the DT cord-103345-v555a2ll 186 18 mouse mouse NN cord-103345-v555a2ll 186 19 CTP CTP NNP cord-103345-v555a2ll 186 20 : : : cord-103345-v555a2ll 186 21 phosphoethanolamine phosphoethanolamine NNP cord-103345-v555a2ll 186 22 cytidylyltransferase cytidylyltransferase NNP cord-103345-v555a2ll 186 23 gene gene NNP cord-103345-v555a2ll 186 24 ( ( -LRB- cord-103345-v555a2ll 186 25 Pcyt2 Pcyt2 NNP cord-103345-v555a2ll 186 26 ) ) -RRB- cord-103345-v555a2ll 187 1 We -PRON- PRP cord-103345-v555a2ll 187 2 thank thank VBP cord-103345-v555a2ll 187 3 Christina Christina NNP cord-103345-v555a2ll 187 4 Fagerberg Fagerberg NNP cord-103345-v555a2ll 187 5 ( ( -LRB- cord-103345-v555a2ll 187 6 Odense Odense NNP cord-103345-v555a2ll 187 7 University University NNP cord-103345-v555a2ll 187 8 , , , cord-103345-v555a2ll 187 9 Denmark Denmark NNP cord-103345-v555a2ll 187 10 ) ) -RRB- cord-103345-v555a2ll 187 11 and and CC cord-103345-v555a2ll 187 12 Felix Felix NNP cord-103345-v555a2ll 187 13 Distelmaier Distelmaier NNP cord-103345-v555a2ll 187 14 _SP cord-103345-v555a2ll 188 1 The the DT cord-103345-v555a2ll 188 2 authors author NNS cord-103345-v555a2ll 188 3 declare declare VBP cord-103345-v555a2ll 188 4 no no DT cord-103345-v555a2ll 188 5 competing compete VBG cord-103345-v555a2ll 188 6 interests interest NNS cord-103345-v555a2ll 188 7 . . .