id sid tid token lemma pos cord-103204-gt6upfri 1 1 key key NN cord-103204-gt6upfri 1 2 : : : cord-103204-gt6upfri 2 1 cord-103204-gt6upfri cord-103204-gt6upfri . cord-103204-gt6upfri 3 1 authors author NNS cord-103204-gt6upfri 3 2 : : : cord-103204-gt6upfri 3 3 Hölzer Hölzer NNP cord-103204-gt6upfri 3 4 , , , cord-103204-gt6upfri 3 5 Martin Martin NNP cord-103204-gt6upfri 3 6 ; ; : cord-103204-gt6upfri 3 7 Marz Marz NNP cord-103204-gt6upfri 3 8 , , , cord-103204-gt6upfri 3 9 Manja Manja NNP cord-103204-gt6upfri 3 10 title title NN cord-103204-gt6upfri 3 11 : : : cord-103204-gt6upfri 3 12 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 3 13 : : : cord-103204-gt6upfri 3 14 a a DT cord-103204-gt6upfri 3 15 Nextflow Nextflow NNP cord-103204-gt6upfri 3 16 pipeline pipeline NN cord-103204-gt6upfri 3 17 for for IN cord-103204-gt6upfri 3 18 the the DT cord-103204-gt6upfri 3 19 detection detection NN cord-103204-gt6upfri 3 20 of of IN cord-103204-gt6upfri 3 21 evolutionary evolutionary JJ cord-103204-gt6upfri 3 22 recombination recombination NN cord-103204-gt6upfri 3 23 events event NNS cord-103204-gt6upfri 3 24 and and CC cord-103204-gt6upfri 3 25 positive positive JJ cord-103204-gt6upfri 3 26 selection selection NN cord-103204-gt6upfri 3 27 date date NN cord-103204-gt6upfri 3 28 : : : cord-103204-gt6upfri 3 29 2020 2020 CD cord-103204-gt6upfri 3 30 - - HYPH cord-103204-gt6upfri 3 31 05 05 CD cord-103204-gt6upfri 3 32 - - HYPH cord-103204-gt6upfri 3 33 20 20 CD cord-103204-gt6upfri 3 34 journal journal NN cord-103204-gt6upfri 3 35 : : : cord-103204-gt6upfri 4 1 bioRxiv biorxiv IN cord-103204-gt6upfri 4 2 DOI DOI NNP cord-103204-gt6upfri 4 3 : : : cord-103204-gt6upfri 5 1 10.1101/2020.05.18.102731 10.1101/2020.05.18.102731 CD cord-103204-gt6upfri 6 1 sha sha NNP cord-103204-gt6upfri 6 2 : : : cord-103204-gt6upfri 6 3 bce116dd6608b571784241a4b2da8e177da9c6ac bce116dd6608b571784241a4b2da8e177da9c6ac NNP cord-103204-gt6upfri 6 4 doc_id doc_id NNP cord-103204-gt6upfri 6 5 : : : cord-103204-gt6upfri 6 6 103204 103204 CD cord-103204-gt6upfri 6 7 cord_uid cord_uid NNS cord-103204-gt6upfri 6 8 : : : cord-103204-gt6upfri 7 1 gt6upfri gt6upfri . cord-103204-gt6upfri 8 1 Summary Summary NNP cord-103204-gt6upfri 8 2 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 8 3 is be VBZ cord-103204-gt6upfri 8 4 an an DT cord-103204-gt6upfri 8 5 easy easy JJ cord-103204-gt6upfri 8 6 - - HYPH cord-103204-gt6upfri 8 7 to to IN cord-103204-gt6upfri 8 8 - - HYPH cord-103204-gt6upfri 8 9 use use NN cord-103204-gt6upfri 8 10 pipeline pipeline NN cord-103204-gt6upfri 8 11 that that WDT cord-103204-gt6upfri 8 12 helps help VBZ cord-103204-gt6upfri 8 13 researchers researcher NNS cord-103204-gt6upfri 8 14 to to TO cord-103204-gt6upfri 8 15 find find VB cord-103204-gt6upfri 8 16 recombination recombination NN cord-103204-gt6upfri 8 17 events event NNS cord-103204-gt6upfri 8 18 and and CC cord-103204-gt6upfri 8 19 sites site NNS cord-103204-gt6upfri 8 20 under under IN cord-103204-gt6upfri 8 21 positive positive JJ cord-103204-gt6upfri 8 22 selection selection NN cord-103204-gt6upfri 8 23 in in IN cord-103204-gt6upfri 8 24 protein protein NN cord-103204-gt6upfri 8 25 - - HYPH cord-103204-gt6upfri 8 26 coding code VBG cord-103204-gt6upfri 8 27 sequences sequence NNS cord-103204-gt6upfri 8 28 . . . cord-103204-gt6upfri 9 1 By by IN cord-103204-gt6upfri 9 2 entering enter VBG cord-103204-gt6upfri 9 3 homologous homologous JJ cord-103204-gt6upfri 9 4 sequences sequence NNS cord-103204-gt6upfri 9 5 , , , cord-103204-gt6upfri 9 6 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 9 7 builds build VBZ cord-103204-gt6upfri 9 8 an an DT cord-103204-gt6upfri 9 9 alignment alignment NN cord-103204-gt6upfri 9 10 , , , cord-103204-gt6upfri 9 11 estimates estimate VBZ cord-103204-gt6upfri 9 12 a a DT cord-103204-gt6upfri 9 13 best well RBS cord-103204-gt6upfri 9 14 - - HYPH cord-103204-gt6upfri 9 15 fitting fitting JJ cord-103204-gt6upfri 9 16 substitution substitution NN cord-103204-gt6upfri 9 17 model model NN cord-103204-gt6upfri 9 18 , , , cord-103204-gt6upfri 9 19 and and CC cord-103204-gt6upfri 9 20 performs perform VBZ cord-103204-gt6upfri 9 21 a a DT cord-103204-gt6upfri 9 22 recombination recombination NN cord-103204-gt6upfri 9 23 analysis analysis NN cord-103204-gt6upfri 9 24 followed follow VBN cord-103204-gt6upfri 9 25 by by IN cord-103204-gt6upfri 9 26 the the DT cord-103204-gt6upfri 9 27 construction construction NN cord-103204-gt6upfri 9 28 of of IN cord-103204-gt6upfri 9 29 all all DT cord-103204-gt6upfri 9 30 corresponding correspond VBG cord-103204-gt6upfri 9 31 phylogenies phylogeny NNS cord-103204-gt6upfri 9 32 . . . cord-103204-gt6upfri 10 1 Finally finally RB cord-103204-gt6upfri 10 2 , , , cord-103204-gt6upfri 10 3 significantly significantly RB cord-103204-gt6upfri 10 4 positive positive JJ cord-103204-gt6upfri 10 5 selected select VBN cord-103204-gt6upfri 10 6 sites site NNS cord-103204-gt6upfri 10 7 are be VBP cord-103204-gt6upfri 10 8 detected detect VBN cord-103204-gt6upfri 10 9 according accord VBG cord-103204-gt6upfri 10 10 to to IN cord-103204-gt6upfri 10 11 different different JJ cord-103204-gt6upfri 10 12 models model NNS cord-103204-gt6upfri 10 13 for for IN cord-103204-gt6upfri 10 14 the the DT cord-103204-gt6upfri 10 15 full full JJ cord-103204-gt6upfri 10 16 alignment alignment NN cord-103204-gt6upfri 10 17 and and CC cord-103204-gt6upfri 10 18 possible possible JJ cord-103204-gt6upfri 10 19 recombination recombination NN cord-103204-gt6upfri 10 20 fragments fragment NNS cord-103204-gt6upfri 10 21 . . . cord-103204-gt6upfri 11 1 The the DT cord-103204-gt6upfri 11 2 results result NNS cord-103204-gt6upfri 11 3 of of IN cord-103204-gt6upfri 11 4 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 11 5 are be VBP cord-103204-gt6upfri 11 6 summarized summarize VBN cord-103204-gt6upfri 11 7 in in IN cord-103204-gt6upfri 11 8 a a DT cord-103204-gt6upfri 11 9 user user NN cord-103204-gt6upfri 11 10 - - HYPH cord-103204-gt6upfri 11 11 friendly friendly JJ cord-103204-gt6upfri 11 12 HTML html NN cord-103204-gt6upfri 11 13 page page NN cord-103204-gt6upfri 11 14 providing provide VBG cord-103204-gt6upfri 11 15 all all DT cord-103204-gt6upfri 11 16 intermediate intermediate JJ cord-103204-gt6upfri 11 17 results result NNS cord-103204-gt6upfri 11 18 and and CC cord-103204-gt6upfri 11 19 the the DT cord-103204-gt6upfri 11 20 graphical graphical JJ cord-103204-gt6upfri 11 21 representation representation NN cord-103204-gt6upfri 11 22 of of IN cord-103204-gt6upfri 11 23 recombination recombination NN cord-103204-gt6upfri 11 24 events event NNS cord-103204-gt6upfri 11 25 and and CC cord-103204-gt6upfri 11 26 positively positively RB cord-103204-gt6upfri 11 27 selected select VBN cord-103204-gt6upfri 11 28 sites site NNS cord-103204-gt6upfri 11 29 . . . cord-103204-gt6upfri 12 1 Availability availability NN cord-103204-gt6upfri 12 2 and and CC cord-103204-gt6upfri 12 3 implementation implementation NN cord-103204-gt6upfri 12 4 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 12 5 is be VBZ cord-103204-gt6upfri 12 6 freely freely RB cord-103204-gt6upfri 12 7 available available JJ cord-103204-gt6upfri 12 8 at at IN cord-103204-gt6upfri 12 9 https://github.com/hoelzer/poseidon https://github.com/hoelzer/poseidon NNP cord-103204-gt6upfri 12 10 . . . cord-103204-gt6upfri 13 1 The the DT cord-103204-gt6upfri 13 2 pipeline pipeline NN cord-103204-gt6upfri 13 3 is be VBZ cord-103204-gt6upfri 13 4 implemented implement VBN cord-103204-gt6upfri 13 5 in in IN cord-103204-gt6upfri 13 6 Nextflow Nextflow NNP cord-103204-gt6upfri 13 7 with with IN cord-103204-gt6upfri 13 8 Docker Docker NNP cord-103204-gt6upfri 13 9 support support NN cord-103204-gt6upfri 13 10 and and CC cord-103204-gt6upfri 13 11 processes process VBZ cord-103204-gt6upfri 13 12 the the DT cord-103204-gt6upfri 13 13 output output NN cord-103204-gt6upfri 13 14 of of IN cord-103204-gt6upfri 13 15 various various JJ cord-103204-gt6upfri 13 16 tools tool NNS cord-103204-gt6upfri 13 17 . . . cord-103204-gt6upfri 14 1 Contact contact NN cord-103204-gt6upfri 14 2 hoelzer.martin@gmail.com hoelzer.martin@gmail.com ADD cord-103204-gt6upfri 15 1 Selection selection NN cord-103204-gt6upfri 15 2 pressure pressure NN cord-103204-gt6upfri 15 3 continuously continuously RB cord-103204-gt6upfri 15 4 influences influence VBZ cord-103204-gt6upfri 15 5 the the DT cord-103204-gt6upfri 15 6 evolution evolution NN cord-103204-gt6upfri 15 7 of of IN cord-103204-gt6upfri 15 8 genes gene NNS cord-103204-gt6upfri 15 9 and and CC cord-103204-gt6upfri 15 10 can can MD cord-103204-gt6upfri 15 11 be be VB cord-103204-gt6upfri 15 12 studied study VBN cord-103204-gt6upfri 15 13 in in IN cord-103204-gt6upfri 15 14 many many JJ cord-103204-gt6upfri 15 15 ways way NNS cord-103204-gt6upfri 15 16 ( ( -LRB- cord-103204-gt6upfri 15 17 Vitti Vitti NNP cord-103204-gt6upfri 15 18 et et NNP cord-103204-gt6upfri 15 19 al al NNP cord-103204-gt6upfri 15 20 . . NNP cord-103204-gt6upfri 15 21 , , , cord-103204-gt6upfri 15 22 2013 2013 CD cord-103204-gt6upfri 15 23 ) ) -RRB- cord-103204-gt6upfri 15 24 . . . cord-103204-gt6upfri 16 1 For for IN cord-103204-gt6upfri 16 2 example example NN cord-103204-gt6upfri 16 3 , , , cord-103204-gt6upfri 16 4 positive positive JJ cord-103204-gt6upfri 16 5 or or CC cord-103204-gt6upfri 16 6 diversifying diversify VBG cord-103204-gt6upfri 16 7 selection selection NN cord-103204-gt6upfri 16 8 can can MD cord-103204-gt6upfri 16 9 be be VB cord-103204-gt6upfri 16 10 detected detect VBN cord-103204-gt6upfri 16 11 by by IN cord-103204-gt6upfri 16 12 comparing compare VBG cord-103204-gt6upfri 16 13 the the DT cord-103204-gt6upfri 16 14 rates rate NNS cord-103204-gt6upfri 16 15 of of IN cord-103204-gt6upfri 16 16 non non JJ cord-103204-gt6upfri 16 17 - - JJ cord-103204-gt6upfri 16 18 synonymous synonymous JJ cord-103204-gt6upfri 16 19 ( ( -LRB- cord-103204-gt6upfri 16 20 dN dn NN cord-103204-gt6upfri 16 21 ) ) -RRB- cord-103204-gt6upfri 16 22 and and CC cord-103204-gt6upfri 16 23 synonymous synonymous JJ cord-103204-gt6upfri 16 24 substitutions substitution NNS cord-103204-gt6upfri 16 25 ( ( -LRB- cord-103204-gt6upfri 16 26 dS dS NNP cord-103204-gt6upfri 16 27 ) ) -RRB- cord-103204-gt6upfri 16 28 in in IN cord-103204-gt6upfri 16 29 an an DT cord-103204-gt6upfri 16 30 alignment alignment NN cord-103204-gt6upfri 16 31 of of IN cord-103204-gt6upfri 16 32 orthologous orthologous JJ cord-103204-gt6upfri 16 33 genes gene NNS cord-103204-gt6upfri 16 34 . . . cord-103204-gt6upfri 17 1 Over over IN cord-103204-gt6upfri 17 2 several several JJ cord-103204-gt6upfri 17 3 sites site NNS cord-103204-gt6upfri 17 4 ( ( -LRB- cord-103204-gt6upfri 17 5 codons codon NNS cord-103204-gt6upfri 17 6 ) ) -RRB- cord-103204-gt6upfri 17 7 , , , cord-103204-gt6upfri 17 8 the the DT cord-103204-gt6upfri 17 9 dN dN NNP cord-103204-gt6upfri 17 10 / / SYM cord-103204-gt6upfri 17 11 dS ds NN cord-103204-gt6upfri 17 12 ratio ratio NN cord-103204-gt6upfri 17 13 ( ( -LRB- cord-103204-gt6upfri 17 14 or or CC cord-103204-gt6upfri 17 15 ω ω LS cord-103204-gt6upfri 17 16 ) ) -RRB- cord-103204-gt6upfri 17 17 can can MD cord-103204-gt6upfri 17 18 reach reach VB cord-103204-gt6upfri 17 19 values value NNS cord-103204-gt6upfri 17 20 well well RB cord-103204-gt6upfri 17 21 above above IN cord-103204-gt6upfri 17 22 1 1 CD cord-103204-gt6upfri 17 23 ( ( -LRB- cord-103204-gt6upfri 17 24 Yang Yang NNP cord-103204-gt6upfri 17 25 , , , cord-103204-gt6upfri 17 26 2007 2007 CD cord-103204-gt6upfri 17 27 ) ) -RRB- cord-103204-gt6upfri 17 28 , , , cord-103204-gt6upfri 17 29 and and CC cord-103204-gt6upfri 17 30 such such JJ cord-103204-gt6upfri 17 31 sites site NNS cord-103204-gt6upfri 17 32 are be VBP cord-103204-gt6upfri 17 33 likely likely JJ cord-103204-gt6upfri 17 34 to to TO cord-103204-gt6upfri 17 35 be be VB cord-103204-gt6upfri 17 36 positively positively RB cord-103204-gt6upfri 17 37 selected select VBN cord-103204-gt6upfri 17 38 . . . cord-103204-gt6upfri 18 1 For for IN cord-103204-gt6upfri 18 2 instance instance NN cord-103204-gt6upfri 18 3 , , , cord-103204-gt6upfri 18 4 specific specific JJ cord-103204-gt6upfri 18 5 amino amino NN cord-103204-gt6upfri 18 6 acid acid NN cord-103204-gt6upfri 18 7 changes change NNS cord-103204-gt6upfri 18 8 are be VBP cord-103204-gt6upfri 18 9 favored favor VBN cord-103204-gt6upfri 18 10 if if IN cord-103204-gt6upfri 18 11 they -PRON- PRP cord-103204-gt6upfri 18 12 increase increase VBP cord-103204-gt6upfri 18 13 the the DT cord-103204-gt6upfri 18 14 host host NN cord-103204-gt6upfri 18 15 's 's POS cord-103204-gt6upfri 18 16 fitness fitness NN cord-103204-gt6upfri 18 17 against against IN cord-103204-gt6upfri 18 18 a a DT cord-103204-gt6upfri 18 19 pathogen pathogen NN cord-103204-gt6upfri 18 20 ( ( -LRB- cord-103204-gt6upfri 18 21 Fumagalli Fumagalli NNP cord-103204-gt6upfri 18 22 et et FW cord-103204-gt6upfri 18 23 al al NNP cord-103204-gt6upfri 18 24 . . NNP cord-103204-gt6upfri 18 25 , , , cord-103204-gt6upfri 18 26 2011 2011 CD cord-103204-gt6upfri 18 27 ) ) -RRB- cord-103204-gt6upfri 18 28 . . . cord-103204-gt6upfri 19 1 Alternatively alternatively RB cord-103204-gt6upfri 19 2 , , , cord-103204-gt6upfri 19 3 the the DT cord-103204-gt6upfri 19 4 genes gene NNS cord-103204-gt6upfri 19 5 of of IN cord-103204-gt6upfri 19 6 a a DT cord-103204-gt6upfri 19 7 pathogen pathogen NN cord-103204-gt6upfri 19 8 are be VBP cord-103204-gt6upfri 19 9 affected affect VBN cord-103204-gt6upfri 19 10 , , , cord-103204-gt6upfri 19 11 as as IN cord-103204-gt6upfri 19 12 in in IN cord-103204-gt6upfri 19 13 the the DT cord-103204-gt6upfri 19 14 COVID COVID NNP cord-103204-gt6upfri 19 15 19 19 CD cord-103204-gt6upfri 19 16 pandemic pandemic NN cord-103204-gt6upfri 19 17 , , , cord-103204-gt6upfri 19 18 where where WRB cord-103204-gt6upfri 19 19 positively positively RB cord-103204-gt6upfri 19 20 selected select VBN cord-103204-gt6upfri 19 21 sites site NNS cord-103204-gt6upfri 19 22 in in IN cord-103204-gt6upfri 19 23 the the DT cord-103204-gt6upfri 19 24 spike spike NN cord-103204-gt6upfri 19 25 protein protein NN cord-103204-gt6upfri 19 26 of of IN cord-103204-gt6upfri 19 27 the the DT cord-103204-gt6upfri 19 28 virus virus NN cord-103204-gt6upfri 19 29 gave give VBD cord-103204-gt6upfri 19 30 cause cause NN cord-103204-gt6upfri 19 31 for for IN cord-103204-gt6upfri 19 32 concern concern NN cord-103204-gt6upfri 20 1 ( ( -LRB- cord-103204-gt6upfri 20 2 Korber Korber NNP cord-103204-gt6upfri 20 3 et et NNP cord-103204-gt6upfri 20 4 al al NNP cord-103204-gt6upfri 20 5 . . NNP cord-103204-gt6upfri 20 6 , , , cord-103204-gt6upfri 20 7 2020 2020 CD cord-103204-gt6upfri 20 8 ) ) -RRB- cord-103204-gt6upfri 20 9 . . . cord-103204-gt6upfri 21 1 The the DT cord-103204-gt6upfri 21 2 detection detection NN cord-103204-gt6upfri 21 3 of of IN cord-103204-gt6upfri 21 4 positive positive JJ cord-103204-gt6upfri 21 5 selection selection NN cord-103204-gt6upfri 21 6 enables enable VBZ cord-103204-gt6upfri 21 7 researchers researcher NNS cord-103204-gt6upfri 21 8 to to TO cord-103204-gt6upfri 21 9 gain gain VB cord-103204-gt6upfri 21 10 insights insight NNS cord-103204-gt6upfri 21 11 into into IN cord-103204-gt6upfri 21 12 the the DT cord-103204-gt6upfri 21 13 evolution evolution NN cord-103204-gt6upfri 21 14 of of IN cord-103204-gt6upfri 21 15 genes gene NNS cord-103204-gt6upfri 21 16 and and CC cord-103204-gt6upfri 21 17 thus thus RB cord-103204-gt6upfri 21 18 develop develop VB cord-103204-gt6upfri 21 19 countermeasures countermeasure NNS cord-103204-gt6upfri 21 20 against against IN cord-103204-gt6upfri 21 21 pathogens pathogen NNS cord-103204-gt6upfri 21 22 that that WDT cord-103204-gt6upfri 21 23 are be VBP cord-103204-gt6upfri 21 24 in in IN cord-103204-gt6upfri 21 25 a a DT cord-103204-gt6upfri 21 26 constant constant JJ cord-103204-gt6upfri 21 27 ' ' `` cord-103204-gt6upfri 21 28 arms arm NNS cord-103204-gt6upfri 21 29 - - HYPH cord-103204-gt6upfri 21 30 race race NN cord-103204-gt6upfri 21 31 ' ' '' cord-103204-gt6upfri 21 32 with with IN cord-103204-gt6upfri 21 33 their -PRON- PRP$ cord-103204-gt6upfri 21 34 host host NN cord-103204-gt6upfri 21 35 . . . cord-103204-gt6upfri 22 1 Since since IN cord-103204-gt6upfri 22 2 recombination recombination NN cord-103204-gt6upfri 22 3 can can MD cord-103204-gt6upfri 22 4 have have VB cord-103204-gt6upfri 22 5 a a DT cord-103204-gt6upfri 22 6 profound profound JJ cord-103204-gt6upfri 22 7 influence influence NN cord-103204-gt6upfri 22 8 on on IN cord-103204-gt6upfri 22 9 evolutionary evolutionary JJ cord-103204-gt6upfri 22 10 processes process NNS cord-103204-gt6upfri 22 11 and and CC cord-103204-gt6upfri 22 12 can can MD cord-103204-gt6upfri 22 13 adversely adversely RB cord-103204-gt6upfri 22 14 affect affect VB cord-103204-gt6upfri 22 15 phylogenetic phylogenetic JJ cord-103204-gt6upfri 22 16 reconstruction reconstruction NN cord-103204-gt6upfri 22 17 and and CC cord-103204-gt6upfri 22 18 the the DT cord-103204-gt6upfri 22 19 accurate accurate JJ cord-103204-gt6upfri 22 20 detection detection NN cord-103204-gt6upfri 22 21 of of IN cord-103204-gt6upfri 22 22 positive positive JJ cord-103204-gt6upfri 22 23 selection selection NN cord-103204-gt6upfri 22 24 ( ( -LRB- cord-103204-gt6upfri 22 25 Shriner Shriner NNP cord-103204-gt6upfri 22 26 et et NNP cord-103204-gt6upfri 22 27 al al NNP cord-103204-gt6upfri 22 28 . . NNP cord-103204-gt6upfri 22 29 , , , cord-103204-gt6upfri 22 30 2003 2003 CD cord-103204-gt6upfri 22 31 ) ) -RRB- cord-103204-gt6upfri 22 32 , , , cord-103204-gt6upfri 22 33 screening screen VBG cord-103204-gt6upfri 22 34 for for IN cord-103204-gt6upfri 22 35 breakpoints breakpoint NNS cord-103204-gt6upfri 22 36 to to TO cord-103204-gt6upfri 22 37 define define VB cord-103204-gt6upfri 22 38 recombinant recombinant JJ cord-103204-gt6upfri 22 39 parts part NNS cord-103204-gt6upfri 22 40 within within IN cord-103204-gt6upfri 22 41 an an DT cord-103204-gt6upfri 22 42 alignment alignment NN cord-103204-gt6upfri 22 43 should should MD cord-103204-gt6upfri 22 44 be be VB cord-103204-gt6upfri 22 45 a a DT cord-103204-gt6upfri 22 46 standard standard JJ cord-103204-gt6upfri 22 47 step step NN cord-103204-gt6upfri 22 48 in in IN cord-103204-gt6upfri 22 49 any any DT cord-103204-gt6upfri 22 50 comparative comparative JJ cord-103204-gt6upfri 22 51 evolutionary evolutionary JJ cord-103204-gt6upfri 22 52 study study NN cord-103204-gt6upfri 22 53 . . . cord-103204-gt6upfri 23 1 A a DT cord-103204-gt6upfri 23 2 comprehensive comprehensive JJ cord-103204-gt6upfri 23 3 evolutionary evolutionary JJ cord-103204-gt6upfri 23 4 analysis analysis NN cord-103204-gt6upfri 23 5 of of IN cord-103204-gt6upfri 23 6 significantly significantly RB cord-103204-gt6upfri 23 7 positively positively RB cord-103204-gt6upfri 23 8 selected select VBN cord-103204-gt6upfri 23 9 sites site NNS cord-103204-gt6upfri 23 10 consist consist VBP cord-103204-gt6upfri 23 11 of of IN cord-103204-gt6upfri 23 12 several several JJ cord-103204-gt6upfri 23 13 complicated complicated JJ cord-103204-gt6upfri 23 14 steps step NNS cord-103204-gt6upfri 23 15 , , , cord-103204-gt6upfri 23 16 including include VBG cord-103204-gt6upfri 23 17 ( ( -LRB- cord-103204-gt6upfri 23 18 1 1 CD cord-103204-gt6upfri 23 19 ) ) -RRB- cord-103204-gt6upfri 23 20 in in IN cord-103204-gt6upfri 23 21 - - HYPH cord-103204-gt6upfri 23 22 frame frame NN cord-103204-gt6upfri 23 23 alignment alignment NN cord-103204-gt6upfri 23 24 ; ; , cord-103204-gt6upfri 23 25 ( ( -LRB- cord-103204-gt6upfri 23 26 2 2 LS cord-103204-gt6upfri 23 27 ) ) -RRB- cord-103204-gt6upfri 23 28 Indel Indel NNP cord-103204-gt6upfri 23 29 correction correction NN cord-103204-gt6upfri 23 30 ; ; , cord-103204-gt6upfri 23 31 ( ( -LRB- cord-103204-gt6upfri 23 32 3 3 LS cord-103204-gt6upfri 23 33 ) ) -RRB- cord-103204-gt6upfri 23 34 phylogenetic phylogenetic JJ cord-103204-gt6upfri 23 35 tree tree NN cord-103204-gt6upfri 23 36 calculation calculation NN cord-103204-gt6upfri 23 37 ; ; : cord-103204-gt6upfri 23 38 ( ( -LRB- cord-103204-gt6upfri 23 39 4 4 LS cord-103204-gt6upfri 23 40 ) ) -RRB- cord-103204-gt6upfri 23 41 selection selection NN cord-103204-gt6upfri 23 42 of of IN cord-103204-gt6upfri 23 43 a a DT cord-103204-gt6upfri 23 44 best well RBS cord-103204-gt6upfri 23 45 - - HYPH cord-103204-gt6upfri 23 46 fitting fitting JJ cord-103204-gt6upfri 23 47 nucleotide nucleotide JJ cord-103204-gt6upfri 23 48 substitution substitution NN cord-103204-gt6upfri 23 49 * * NFP cord-103204-gt6upfri 23 50 To to TO cord-103204-gt6upfri 23 51 whom whom WP cord-103204-gt6upfri 23 52 correspondence correspondence NN cord-103204-gt6upfri 23 53 should should MD cord-103204-gt6upfri 23 54 be be VB cord-103204-gt6upfri 23 55 addressed address VBN cord-103204-gt6upfri 23 56 . . . cord-103204-gt6upfri 24 1 model model NN cord-103204-gt6upfri 24 2 ; ; , cord-103204-gt6upfri 24 3 ( ( -LRB- cord-103204-gt6upfri 24 4 5 5 LS cord-103204-gt6upfri 24 5 ) ) -RRB- cord-103204-gt6upfri 24 6 detection detection NN cord-103204-gt6upfri 24 7 of of IN cord-103204-gt6upfri 24 8 topological topological JJ cord-103204-gt6upfri 24 9 incongruence incongruence NN cord-103204-gt6upfri 24 10 and and CC cord-103204-gt6upfri 24 11 breakpoint breakpoint NN cord-103204-gt6upfri 24 12 selection selection NN cord-103204-gt6upfri 24 13 to to TO cord-103204-gt6upfri 24 14 describe describe VB cord-103204-gt6upfri 24 15 putative putative JJ cord-103204-gt6upfri 24 16 recombination recombination NN cord-103204-gt6upfri 24 17 events event NNS cord-103204-gt6upfri 24 18 ; ; , cord-103204-gt6upfri 24 19 ( ( -LRB- cord-103204-gt6upfri 24 20 6 6 LS cord-103204-gt6upfri 24 21 ) ) -RRB- cord-103204-gt6upfri 24 22 calculation calculation NN cord-103204-gt6upfri 24 23 of of IN cord-103204-gt6upfri 24 24 positively positively RB cord-103204-gt6upfri 24 25 selected select VBN cord-103204-gt6upfri 24 26 sites site NNS cord-103204-gt6upfri 24 27 ( ( -LRB- cord-103204-gt6upfri 24 28 ω ω NN cord-103204-gt6upfri 24 29 > > XX cord-103204-gt6upfri 24 30 1 1 CD cord-103204-gt6upfri 24 31 ) ) -RRB- cord-103204-gt6upfri 24 32 under under IN cord-103204-gt6upfri 24 33 varying vary VBG cord-103204-gt6upfri 24 34 models model NNS cord-103204-gt6upfri 24 35 ; ; , cord-103204-gt6upfri 24 36 ( ( -LRB- cord-103204-gt6upfri 24 37 7 7 CD cord-103204-gt6upfri 24 38 ) ) -RRB- cord-103204-gt6upfri 24 39 and and CC cord-103204-gt6upfri 24 40 their -PRON- PRP$ cord-103204-gt6upfri 24 41 impact impact NN cord-103204-gt6upfri 24 42 on on IN cord-103204-gt6upfri 24 43 the the DT cord-103204-gt6upfri 24 44 selective selective JJ cord-103204-gt6upfri 24 45 pressure pressure NN cord-103204-gt6upfri 24 46 acting act VBG cord-103204-gt6upfri 24 47 on on IN cord-103204-gt6upfri 24 48 the the DT cord-103204-gt6upfri 24 49 whole whole JJ cord-103204-gt6upfri 24 50 alignment alignment NN cord-103204-gt6upfri 24 51 . . . cord-103204-gt6upfri 25 1 Thus thus RB cord-103204-gt6upfri 25 2 , , , cord-103204-gt6upfri 25 3 such such PDT cord-103204-gt6upfri 25 4 an an DT cord-103204-gt6upfri 25 5 analysis analysis NN cord-103204-gt6upfri 25 6 involves involve VBZ cord-103204-gt6upfri 25 7 dozens dozen NNS cord-103204-gt6upfri 25 8 of of IN cord-103204-gt6upfri 25 9 different different JJ cord-103204-gt6upfri 25 10 tools tool NNS cord-103204-gt6upfri 25 11 and and CC cord-103204-gt6upfri 25 12 parameter parameter NN cord-103204-gt6upfri 25 13 settings setting NNS cord-103204-gt6upfri 25 14 . . . cord-103204-gt6upfri 26 1 In in IN cord-103204-gt6upfri 26 2 addition addition NN cord-103204-gt6upfri 26 3 , , , cord-103204-gt6upfri 26 4 the the DT cord-103204-gt6upfri 26 5 results result NNS cord-103204-gt6upfri 26 6 of of IN cord-103204-gt6upfri 26 7 many many JJ cord-103204-gt6upfri 26 8 well well RB cord-103204-gt6upfri 26 9 - - HYPH cord-103204-gt6upfri 26 10 established establish VBN cord-103204-gt6upfri 26 11 and and CC cord-103204-gt6upfri 26 12 widely widely RB cord-103204-gt6upfri 26 13 used use VBN cord-103204-gt6upfri 26 14 tools tool NNS cord-103204-gt6upfri 26 15 in in IN cord-103204-gt6upfri 26 16 this this DT cord-103204-gt6upfri 26 17 field field NN cord-103204-gt6upfri 26 18 of of IN cord-103204-gt6upfri 26 19 evolutionary evolutionary JJ cord-103204-gt6upfri 26 20 science science NN cord-103204-gt6upfri 26 21 are be VBP cord-103204-gt6upfri 26 22 not not RB cord-103204-gt6upfri 26 23 easy easy JJ cord-103204-gt6upfri 26 24 to to TO cord-103204-gt6upfri 26 25 interpret interpret VB cord-103204-gt6upfri 26 26 and and CC cord-103204-gt6upfri 26 27 process process VB cord-103204-gt6upfri 26 28 . . . cord-103204-gt6upfri 27 1 Especially especially RB cord-103204-gt6upfri 27 2 , , , cord-103204-gt6upfri 27 3 the the DT cord-103204-gt6upfri 27 4 accurate accurate JJ cord-103204-gt6upfri 27 5 detection detection NN cord-103204-gt6upfri 27 6 and and CC cord-103204-gt6upfri 27 7 handling handling NN cord-103204-gt6upfri 27 8 of of IN cord-103204-gt6upfri 27 9 putative putative JJ cord-103204-gt6upfri 27 10 recombination recombination NN cord-103204-gt6upfri 27 11 events event NNS cord-103204-gt6upfri 27 12 is be VBZ cord-103204-gt6upfri 27 13 a a DT cord-103204-gt6upfri 27 14 challenging challenging JJ cord-103204-gt6upfri 27 15 but but CC cord-103204-gt6upfri 27 16 essential essential JJ cord-103204-gt6upfri 27 17 task task NN cord-103204-gt6upfri 27 18 . . . cord-103204-gt6upfri 28 1 Currently currently RB cord-103204-gt6upfri 28 2 , , , cord-103204-gt6upfri 28 3 only only RB cord-103204-gt6upfri 28 4 a a DT cord-103204-gt6upfri 28 5 few few JJ cord-103204-gt6upfri 28 6 tools tool NNS cord-103204-gt6upfri 28 7 for for IN cord-103204-gt6upfri 28 8 the the DT cord-103204-gt6upfri 28 9 comprehensive comprehensive JJ cord-103204-gt6upfri 28 10 detection detection NN cord-103204-gt6upfri 28 11 of of IN cord-103204-gt6upfri 28 12 positive positive JJ cord-103204-gt6upfri 28 13 selection selection NN cord-103204-gt6upfri 28 14 exist exist VBP cord-103204-gt6upfri 28 15 . . . cord-103204-gt6upfri 29 1 These these DT cord-103204-gt6upfri 29 2 tools tool NNS cord-103204-gt6upfri 29 3 either either CC cord-103204-gt6upfri 29 4 do do VBP cord-103204-gt6upfri 29 5 not not RB cord-103204-gt6upfri 29 6 automatically automatically RB cord-103204-gt6upfri 29 7 combine combine VB cord-103204-gt6upfri 29 8 all all DT cord-103204-gt6upfri 29 9 of of IN cord-103204-gt6upfri 29 10 the the DT cord-103204-gt6upfri 29 11 described describe VBN cord-103204-gt6upfri 29 12 steps step NNS cord-103204-gt6upfri 29 13 ( ( -LRB- cord-103204-gt6upfri 29 14 Delport Delport NNP cord-103204-gt6upfri 29 15 et et NNP cord-103204-gt6upfri 29 16 al al NNP cord-103204-gt6upfri 29 17 . . NNP cord-103204-gt6upfri 29 18 , , , cord-103204-gt6upfri 29 19 2010 2010 CD cord-103204-gt6upfri 29 20 ) ) -RRB- cord-103204-gt6upfri 29 21 , , , cord-103204-gt6upfri 29 22 do do VBP cord-103204-gt6upfri 29 23 not not RB cord-103204-gt6upfri 29 24 take take VB cord-103204-gt6upfri 29 25 possible possible JJ cord-103204-gt6upfri 29 26 recombination recombination NN cord-103204-gt6upfri 29 27 events event NNS cord-103204-gt6upfri 29 28 into into IN cord-103204-gt6upfri 29 29 account account NN cord-103204-gt6upfri 30 1 ( ( -LRB- cord-103204-gt6upfri 30 2 Doron Doron NNP cord-103204-gt6upfri 30 3 - - HYPH cord-103204-gt6upfri 30 4 Faigenboim Faigenboim NNP cord-103204-gt6upfri 30 5 et et NNP cord-103204-gt6upfri 30 6 al al NNP cord-103204-gt6upfri 30 7 . . . cord-103204-gt6upfri 31 1 , , , cord-103204-gt6upfri 31 2 2005 2005 CD cord-103204-gt6upfri 31 3 ; ; : cord-103204-gt6upfri 31 4 Stern Stern NNP cord-103204-gt6upfri 31 5 et et FW cord-103204-gt6upfri 31 6 al al NNP cord-103204-gt6upfri 31 7 . . NNP cord-103204-gt6upfri 31 8 , , , cord-103204-gt6upfri 31 9 2007 2007 CD cord-103204-gt6upfri 31 10 ; ; : cord-103204-gt6upfri 31 11 Webb Webb NNP cord-103204-gt6upfri 31 12 et et NNP cord-103204-gt6upfri 31 13 al al NNP cord-103204-gt6upfri 31 14 . . NNP cord-103204-gt6upfri 31 15 , , , cord-103204-gt6upfri 31 16 2017 2017 CD cord-103204-gt6upfri 31 17 ) ) -RRB- cord-103204-gt6upfri 31 18 , , , cord-103204-gt6upfri 31 19 or or CC cord-103204-gt6upfri 31 20 focus focus VBP cord-103204-gt6upfri 31 21 only only RB cord-103204-gt6upfri 31 22 on on IN cord-103204-gt6upfri 31 23 the the DT cord-103204-gt6upfri 31 24 detection detection NN cord-103204-gt6upfri 31 25 of of IN cord-103204-gt6upfri 31 26 positive positive JJ cord-103204-gt6upfri 31 27 selection selection NN cord-103204-gt6upfri 31 28 in in IN cord-103204-gt6upfri 31 29 prokaryotic prokaryotic JJ cord-103204-gt6upfri 31 30 genomes genome NNS cord-103204-gt6upfri 31 31 ( ( -LRB- cord-103204-gt6upfri 31 32 Su Su NNP cord-103204-gt6upfri 31 33 et et FW cord-103204-gt6upfri 31 34 al al NNP cord-103204-gt6upfri 31 35 . . NNP cord-103204-gt6upfri 31 36 , , , cord-103204-gt6upfri 31 37 2013 2013 CD cord-103204-gt6upfri 31 38 ) ) -RRB- cord-103204-gt6upfri 31 39 . . . cord-103204-gt6upfri 32 1 Here here RB cord-103204-gt6upfri 32 2 we -PRON- PRP cord-103204-gt6upfri 32 3 present present VBP cord-103204-gt6upfri 32 4 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 32 5 , , , cord-103204-gt6upfri 32 6 a a DT cord-103204-gt6upfri 32 7 pipeline pipeline NN cord-103204-gt6upfri 32 8 that that WDT cord-103204-gt6upfri 32 9 allows allow VBZ cord-103204-gt6upfri 32 10 researchers researcher NNS cord-103204-gt6upfri 32 11 to to TO cord-103204-gt6upfri 32 12 perform perform VB cord-103204-gt6upfri 32 13 comprehensive comprehensive JJ cord-103204-gt6upfri 32 14 evolutionary evolutionary JJ cord-103204-gt6upfri 32 15 studies study NNS cord-103204-gt6upfri 32 16 by by IN cord-103204-gt6upfri 32 17 automatically automatically RB cord-103204-gt6upfri 32 18 taking take VBG cord-103204-gt6upfri 32 19 care care NN cord-103204-gt6upfri 32 20 of of IN cord-103204-gt6upfri 32 21 all all DT cord-103204-gt6upfri 32 22 tasks task NNS cord-103204-gt6upfri 32 23 mentioned mention VBN cord-103204-gt6upfri 32 24 above above RB cord-103204-gt6upfri 32 25 . . . cord-103204-gt6upfri 33 1 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 33 2 does do VBZ cord-103204-gt6upfri 33 3 detect detect VB cord-103204-gt6upfri 33 4 not not RB cord-103204-gt6upfri 33 5 only only RB cord-103204-gt6upfri 33 6 positively positively RB cord-103204-gt6upfri 33 7 selected select VBN cord-103204-gt6upfri 33 8 sites site NNS cord-103204-gt6upfri 33 9 in in IN cord-103204-gt6upfri 33 10 an an DT cord-103204-gt6upfri 33 11 alignment alignment NN cord-103204-gt6upfri 33 12 of of IN cord-103204-gt6upfri 33 13 homologous homologous JJ cord-103204-gt6upfri 33 14 sequences sequence NNS cord-103204-gt6upfri 33 15 but but CC cord-103204-gt6upfri 33 16 also also RB cord-103204-gt6upfri 33 17 possible possible JJ cord-103204-gt6upfri 33 18 recombination recombination NN cord-103204-gt6upfri 33 19 events event NNS cord-103204-gt6upfri 33 20 that that WDT cord-103204-gt6upfri 33 21 could could MD cord-103204-gt6upfri 33 22 otherwise otherwise RB cord-103204-gt6upfri 33 23 adversely adversely RB cord-103204-gt6upfri 33 24 affect affect VB cord-103204-gt6upfri 33 25 the the DT cord-103204-gt6upfri 33 26 positive positive JJ cord-103204-gt6upfri 33 27 selection selection NN cord-103204-gt6upfri 33 28 detection detection NN cord-103204-gt6upfri 33 29 . . . cord-103204-gt6upfri 34 1 The the DT cord-103204-gt6upfri 34 2 input input NN cord-103204-gt6upfri 34 3 is be VBZ cord-103204-gt6upfri 34 4 a a DT cord-103204-gt6upfri 34 5 single single JJ cord-103204-gt6upfri 34 6 FASTA FASTA NNP cord-103204-gt6upfri 34 7 file file NN cord-103204-gt6upfri 34 8 consisting consist VBG cord-103204-gt6upfri 34 9 of of IN cord-103204-gt6upfri 34 10 protein protein NN cord-103204-gt6upfri 34 11 - - HYPH cord-103204-gt6upfri 34 12 coding code VBG cord-103204-gt6upfri 34 13 DNA dna NN cord-103204-gt6upfri 34 14 sequences sequence NNS cord-103204-gt6upfri 34 15 with with IN cord-103204-gt6upfri 34 16 a a DT cord-103204-gt6upfri 34 17 correct correct JJ cord-103204-gt6upfri 34 18 open open JJ cord-103204-gt6upfri 34 19 reading reading NN cord-103204-gt6upfri 34 20 frame frame NN cord-103204-gt6upfri 34 21 . . . cord-103204-gt6upfri 35 1 The the DT cord-103204-gt6upfri 35 2 output output NN cord-103204-gt6upfri 35 3 is be VBZ cord-103204-gt6upfri 35 4 summarized summarize VBN cord-103204-gt6upfri 35 5 in in IN cord-103204-gt6upfri 35 6 T T NNP cord-103204-gt6upfri 35 7 E E NNP cord-103204-gt6upfri 35 8 X X NNP cord-103204-gt6upfri 35 9 and and CC cord-103204-gt6upfri 35 10 PDF PDF NNP cord-103204-gt6upfri 35 11 format format NN cord-103204-gt6upfri 35 12 and and CC cord-103204-gt6upfri 35 13 visualized visualize VBD cord-103204-gt6upfri 35 14 in in IN cord-103204-gt6upfri 35 15 a a DT cord-103204-gt6upfri 35 16 user user NN cord-103204-gt6upfri 35 17 - - HYPH cord-103204-gt6upfri 35 18 friendly friendly JJ cord-103204-gt6upfri 35 19 HTML html NN cord-103204-gt6upfri 35 20 page page NN cord-103204-gt6upfri 35 21 , , , cord-103204-gt6upfri 35 22 providing provide VBG cord-103204-gt6upfri 35 23 access access NN cord-103204-gt6upfri 35 24 to to IN cord-103204-gt6upfri 35 25 all all DT cord-103204-gt6upfri 35 26 results result NNS cord-103204-gt6upfri 35 27 and and CC cord-103204-gt6upfri 35 28 intermediate intermediate JJ cord-103204-gt6upfri 35 29 files file NNS cord-103204-gt6upfri 35 30 . . . cord-103204-gt6upfri 36 1 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 36 2 comprises comprise VBZ cord-103204-gt6upfri 36 3 an an DT cord-103204-gt6upfri 36 4 assembly assembly NN cord-103204-gt6upfri 36 5 of of IN cord-103204-gt6upfri 36 6 different different JJ cord-103204-gt6upfri 36 7 scripts script NNS cord-103204-gt6upfri 36 8 and and CC cord-103204-gt6upfri 36 9 tools tool NNS cord-103204-gt6upfri 36 10 ( ( -LRB- cord-103204-gt6upfri 36 11 Fig fig NN cord-103204-gt6upfri 36 12 . . . cord-103204-gt6upfri 36 13 1 1 CD cord-103204-gt6upfri 36 14 ) ) -RRB- cord-103204-gt6upfri 37 1 that that WDT cord-103204-gt6upfri 37 2 allow allow VB cord-103204-gt6upfri 37 3 for for IN cord-103204-gt6upfri 37 4 the the DT cord-103204-gt6upfri 37 5 detection detection NN cord-103204-gt6upfri 37 6 of of IN cord-103204-gt6upfri 37 7 recombination recombination NN cord-103204-gt6upfri 37 8 and and CC cord-103204-gt6upfri 37 9 positive positive JJ cord-103204-gt6upfri 37 10 selection selection NN cord-103204-gt6upfri 37 11 in in IN cord-103204-gt6upfri 37 12 protein protein NN cord-103204-gt6upfri 37 13 - - HYPH cord-103204-gt6upfri 37 14 coding code VBG cord-103204-gt6upfri 37 15 sequences sequence NNS cord-103204-gt6upfri 37 16 . . . cord-103204-gt6upfri 38 1 Each each DT cord-103204-gt6upfri 38 2 third third JJ cord-103204-gt6upfri 38 3 - - HYPH cord-103204-gt6upfri 38 4 party party NN cord-103204-gt6upfri 38 5 tool tool NN cord-103204-gt6upfri 38 6 encapsulates encapsulate VBZ cord-103204-gt6upfri 38 7 in in IN cord-103204-gt6upfri 38 8 a a DT cord-103204-gt6upfri 38 9 Docker Docker NNP cord-103204-gt6upfri 38 10 container container NN cord-103204-gt6upfri 38 11 and and CC cord-103204-gt6upfri 38 12 all all DT cord-103204-gt6upfri 38 13 steps step NNS cord-103204-gt6upfri 38 14 are be VBP cord-103204-gt6upfri 38 15 connected connect VBN cord-103204-gt6upfri 38 16 in in IN cord-103204-gt6upfri 38 17 a a DT cord-103204-gt6upfri 38 18 Nextflow Nextflow NNP cord-103204-gt6upfri 38 19 ( ( -LRB- cord-103204-gt6upfri 38 20 Di Di NNP cord-103204-gt6upfri 38 21 Tommaso Tommaso NNP cord-103204-gt6upfri 38 22 et et FW cord-103204-gt6upfri 38 23 al al NNP cord-103204-gt6upfri 38 24 . . NNP cord-103204-gt6upfri 38 25 , , , cord-103204-gt6upfri 38 26 2017 2017 CD cord-103204-gt6upfri 38 27 ) ) -RRB- cord-103204-gt6upfri 38 28 implementation implementation NN cord-103204-gt6upfri 38 29 for for IN cord-103204-gt6upfri 38 30 full full JJ cord-103204-gt6upfri 38 31 parallelization parallelization NN cord-103204-gt6upfri 38 32 and and CC cord-103204-gt6upfri 38 33 simple simple JJ cord-103204-gt6upfri 38 34 execution execution NN cord-103204-gt6upfri 38 35 . . . cord-103204-gt6upfri 39 1 If if IN cord-103204-gt6upfri 39 2 Nextflow Nextflow NNP cord-103204-gt6upfri 39 3 and and CC cord-103204-gt6upfri 39 4 Docker Docker NNP cord-103204-gt6upfri 39 5 are be VBP cord-103204-gt6upfri 39 6 configured configure VBN cord-103204-gt6upfri 39 7 , , , cord-103204-gt6upfri 39 8 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 39 9 can can MD cord-103204-gt6upfri 39 10 be be VB cord-103204-gt6upfri 39 11 installed instal VBN cord-103204-gt6upfri 39 12 and and CC cord-103204-gt6upfri 39 13 run run VBN cord-103204-gt6upfri 39 14 with with IN cord-103204-gt6upfri 39 15 a a DT cord-103204-gt6upfri 39 16 single single JJ cord-103204-gt6upfri 39 17 command command NN cord-103204-gt6upfri 39 18 : : : cord-103204-gt6upfri 39 19 nextflow nextflow NNP cord-103204-gt6upfri 39 20 run run NNP cord-103204-gt6upfri 40 1 hoelzer hoelzer NNP cord-103204-gt6upfri 40 2 / / SYM cord-103204-gt6upfri 40 3 poseidon poseidon NNP cord-103204-gt6upfri 40 4 --help --help NNP cord-103204-gt6upfri 40 5 . . . cord-103204-gt6upfri 41 1 Different different JJ cord-103204-gt6upfri 41 2 profiles profile NNS cord-103204-gt6upfri 41 3 allow allow VBP cord-103204-gt6upfri 41 4 the the DT cord-103204-gt6upfri 41 5 reliable reliable JJ cord-103204-gt6upfri 41 6 execution execution NN cord-103204-gt6upfri 41 7 of of IN cord-103204-gt6upfri 41 8 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 41 9 in in IN cord-103204-gt6upfri 41 10 the the DT cord-103204-gt6upfri 41 11 cloud cloud NN cord-103204-gt6upfri 41 12 or or CC cord-103204-gt6upfri 41 13 on on IN cord-103204-gt6upfri 41 14 a a DT cord-103204-gt6upfri 41 15 cluster cluster NN cord-103204-gt6upfri 41 16 system system NN cord-103204-gt6upfri 41 17 . . . cord-103204-gt6upfri 42 1 Starting start VBG cord-103204-gt6upfri 42 2 from from IN cord-103204-gt6upfri 42 3 homologous homologous JJ cord-103204-gt6upfri 42 4 coding coding NN cord-103204-gt6upfri 42 5 sequences sequence NNS cord-103204-gt6upfri 42 6 provided provide VBN cord-103204-gt6upfri 42 7 by by IN cord-103204-gt6upfri 42 8 the the DT cord-103204-gt6upfri 42 9 user user NN cord-103204-gt6upfri 42 10 , , , cord-103204-gt6upfri 42 11 we -PRON- PRP cord-103204-gt6upfri 42 12 build build VBP cord-103204-gt6upfri 42 13 a a DT cord-103204-gt6upfri 42 14 multiple multiple JJ cord-103204-gt6upfri 42 15 sequence sequence NN cord-103204-gt6upfri 42 16 alignment alignment NN cord-103204-gt6upfri 42 17 guided guide VBN cord-103204-gt6upfri 42 18 by by IN cord-103204-gt6upfri 42 19 amino amino NN cord-103204-gt6upfri 42 20 acid acid JJ cord-103204-gt6upfri 42 21 information information NN cord-103204-gt6upfri 42 22 with with IN cord-103204-gt6upfri 42 23 TranslatorX TranslatorX NNP cord-103204-gt6upfri 42 24 ( ( -LRB- cord-103204-gt6upfri 42 25 v1.1 v1.1 NN cord-103204-gt6upfri 42 26 ) ) -RRB- cord-103204-gt6upfri 43 1 ( ( -LRB- cord-103204-gt6upfri 43 2 Abascal Abascal NNP cord-103204-gt6upfri 43 3 et et FW cord-103204-gt6upfri 43 4 al al NNP cord-103204-gt6upfri 43 5 . . NNP cord-103204-gt6upfri 43 6 , , , cord-103204-gt6upfri 43 7 2010 2010 CD cord-103204-gt6upfri 43 8 ) ) -RRB- cord-103204-gt6upfri 43 9 , , , cord-103204-gt6upfri 43 10 using use VBG cord-103204-gt6upfri 43 11 Muscle Muscle NNP cord-103204-gt6upfri 43 12 ( ( -LRB- cord-103204-gt6upfri 43 13 v3.8.31 v3.8.31 NNP cord-103204-gt6upfri 43 14 ) ) -RRB- cord-103204-gt6upfri 44 1 ( ( -LRB- cord-103204-gt6upfri 44 2 Edgar Edgar NNP cord-103204-gt6upfri 44 3 , , , cord-103204-gt6upfri 44 4 2004 2004 CD cord-103204-gt6upfri 44 5 ) ) -RRB- cord-103204-gt6upfri 44 6 to to TO cord-103204-gt6upfri 44 7 align align VB cord-103204-gt6upfri 44 8 the the DT cord-103204-gt6upfri 44 9 sequences sequence NNS cord-103204-gt6upfri 44 10 . . . cord-103204-gt6upfri 45 1 The the DT cord-103204-gt6upfri 45 2 resulting result VBG cord-103204-gt6upfri 45 3 in in IN cord-103204-gt6upfri 45 4 - - HYPH cord-103204-gt6upfri 45 5 frame frame NN cord-103204-gt6upfri 45 6 nucleotide nucleotide JJ cord-103204-gt6upfri 45 7 alignment alignment NN cord-103204-gt6upfri 45 8 is be VBZ cord-103204-gt6upfri 45 9 cleaned clean VBN cord-103204-gt6upfri 45 10 for for IN cord-103204-gt6upfri 45 11 Indels Indels NNPS cord-103204-gt6upfri 45 12 . . . cord-103204-gt6upfri 46 1 A a DT cord-103204-gt6upfri 46 2 best well RBS cord-103204-gt6upfri 46 3 - - HYPH cord-103204-gt6upfri 46 4 fitting fitting JJ cord-103204-gt6upfri 46 5 substitution substitution NN cord-103204-gt6upfri 46 6 model model NN cord-103204-gt6upfri 46 7 is be VBZ cord-103204-gt6upfri 46 8 selected select VBN cord-103204-gt6upfri 46 9 c c NN cord-103204-gt6upfri 46 10 Oxford Oxford NNP cord-103204-gt6upfri 46 11 University University NNP cord-103204-gt6upfri 46 12 Press Press NNP cord-103204-gt6upfri 46 13 2016 2016 CD cord-103204-gt6upfri 46 14 . . . cord-103204-gt6upfri 47 1 using use VBG cord-103204-gt6upfri 47 2 MODELTEST MODELTEST NNP cord-103204-gt6upfri 48 1 ( ( -LRB- cord-103204-gt6upfri 48 2 Posada Posada NNP cord-103204-gt6upfri 48 3 and and CC cord-103204-gt6upfri 48 4 Crandall Crandall NNP cord-103204-gt6upfri 48 5 , , , cord-103204-gt6upfri 48 6 1998 1998 CD cord-103204-gt6upfri 48 7 ) ) -RRB- cord-103204-gt6upfri 48 8 , , , cord-103204-gt6upfri 48 9 which which WDT cord-103204-gt6upfri 48 10 is be VBZ cord-103204-gt6upfri 48 11 part part NN cord-103204-gt6upfri 48 12 of of IN cord-103204-gt6upfri 48 13 the the DT cord-103204-gt6upfri 48 14 HyPhy HyPhy NNP cord-103204-gt6upfri 48 15 suite suite NN cord-103204-gt6upfri 48 16 ( ( -LRB- cord-103204-gt6upfri 48 17 v2.2.7 v2.2.7 NNP cord-103204-gt6upfri 48 18 ) ) -RRB- cord-103204-gt6upfri 49 1 ( ( -LRB- cord-103204-gt6upfri 49 2 Pond Pond NNP cord-103204-gt6upfri 49 3 et et NNP cord-103204-gt6upfri 49 4 al al NNP cord-103204-gt6upfri 49 5 . . NNP cord-103204-gt6upfri 49 6 , , , cord-103204-gt6upfri 49 7 2005 2005 CD cord-103204-gt6upfri 49 8 ) ) -RRB- cord-103204-gt6upfri 49 9 . . . cord-103204-gt6upfri 50 1 Possible possible JJ cord-103204-gt6upfri 50 2 recombination recombination NN cord-103204-gt6upfri 50 3 events event NNS cord-103204-gt6upfri 50 4 and and CC cord-103204-gt6upfri 50 5 corresponding correspond VBG cord-103204-gt6upfri 50 6 breakpoints breakpoint NNS cord-103204-gt6upfri 50 7 in in IN cord-103204-gt6upfri 50 8 the the DT cord-103204-gt6upfri 50 9 alignment alignment NN cord-103204-gt6upfri 50 10 are be VBP cord-103204-gt6upfri 50 11 detected detect VBN cord-103204-gt6upfri 50 12 using use VBG cord-103204-gt6upfri 50 13 GARD GARD NNP cord-103204-gt6upfri 50 14 ( ( -LRB- cord-103204-gt6upfri 50 15 Pond Pond NNP cord-103204-gt6upfri 50 16 et et NNP cord-103204-gt6upfri 50 17 al al NNP cord-103204-gt6upfri 50 18 . . NNP cord-103204-gt6upfri 50 19 , , , cord-103204-gt6upfri 50 20 2006b 2006b CD cord-103204-gt6upfri 50 21 , , , cord-103204-gt6upfri 50 22 a a LS cord-103204-gt6upfri 50 23 ) ) -RRB- cord-103204-gt6upfri 50 24 under under IN cord-103204-gt6upfri 50 25 the the DT cord-103204-gt6upfri 50 26 previously previously RB cord-103204-gt6upfri 50 27 selected select VBN cord-103204-gt6upfri 50 28 substitution substitution NN cord-103204-gt6upfri 50 29 model model NN cord-103204-gt6upfri 50 30 . . . cord-103204-gt6upfri 51 1 All all DT cord-103204-gt6upfri 51 2 breakpoints breakpoint NNS cord-103204-gt6upfri 51 3 are be VBP cord-103204-gt6upfri 51 4 tested test VBN cord-103204-gt6upfri 51 5 for for IN cord-103204-gt6upfri 51 6 significant significant JJ cord-103204-gt6upfri 51 7 topological topological JJ cord-103204-gt6upfri 51 8 incongruence incongruence NN cord-103204-gt6upfri 51 9 using use VBG cord-103204-gt6upfri 51 10 a a DT cord-103204-gt6upfri 51 11 Kashino Kashino NNP cord-103204-gt6upfri 51 12 Hasegawa Hasegawa NNP cord-103204-gt6upfri 51 13 ( ( -LRB- cord-103204-gt6upfri 51 14 KH KH NNP cord-103204-gt6upfri 51 15 ) ) -RRB- cord-103204-gt6upfri 51 16 test test NN cord-103204-gt6upfri 51 17 ( ( -LRB- cord-103204-gt6upfri 51 18 Kishino Kishino NNP cord-103204-gt6upfri 51 19 and and CC cord-103204-gt6upfri 51 20 Hasegawa Hasegawa NNP cord-103204-gt6upfri 51 21 , , , cord-103204-gt6upfri 51 22 1989 1989 CD cord-103204-gt6upfri 51 23 ) ) -RRB- cord-103204-gt6upfri 51 24 . . . cord-103204-gt6upfri 52 1 KHinsignificant khinsignificant JJ cord-103204-gt6upfri 52 2 breakpoints breakpoint NNS cord-103204-gt6upfri 52 3 most most RBS cord-103204-gt6upfri 52 4 frequently frequently RB cord-103204-gt6upfri 52 5 arise arise VBP cord-103204-gt6upfri 52 6 from from IN cord-103204-gt6upfri 52 7 variation variation NN cord-103204-gt6upfri 52 8 in in IN cord-103204-gt6upfri 52 9 branch branch NN cord-103204-gt6upfri 52 10 lengths length NNS cord-103204-gt6upfri 52 11 between between IN cord-103204-gt6upfri 52 12 segments segment NNS cord-103204-gt6upfri 52 13 . . . cord-103204-gt6upfri 53 1 However however RB cord-103204-gt6upfri 53 2 , , , cord-103204-gt6upfri 53 3 we -PRON- PRP cord-103204-gt6upfri 53 4 observed observe VBD cord-103204-gt6upfri 53 5 interesting interesting JJ cord-103204-gt6upfri 53 6 positively positively RB cord-103204-gt6upfri 53 7 selected select VBN cord-103204-gt6upfri 53 8 sites site NNS cord-103204-gt6upfri 53 9 in in IN cord-103204-gt6upfri 53 10 fragments fragment NNS cord-103204-gt6upfri 53 11 without without IN cord-103204-gt6upfri 53 12 any any DT cord-103204-gt6upfri 53 13 significant significant JJ cord-103204-gt6upfri 53 14 topological topological JJ cord-103204-gt6upfri 53 15 incongruence incongruence NN cord-103204-gt6upfri 53 16 ( ( -LRB- cord-103204-gt6upfri 53 17 Fuchs Fuchs NNP cord-103204-gt6upfri 53 18 et et FW cord-103204-gt6upfri 53 19 al al NNP cord-103204-gt6upfri 53 20 . . NNP cord-103204-gt6upfri 53 21 , , , cord-103204-gt6upfri 53 22 2017 2017 CD cord-103204-gt6upfri 53 23 ) ) -RRB- cord-103204-gt6upfri 53 24 . . . cord-103204-gt6upfri 54 1 Thus thus RB cord-103204-gt6upfri 54 2 , , , cord-103204-gt6upfri 54 3 KH kh NN cord-103204-gt6upfri 54 4 - - HYPH cord-103204-gt6upfri 54 5 insignificant insignificant JJ cord-103204-gt6upfri 54 6 breakpoints breakpoint NNS cord-103204-gt6upfri 54 7 can can MD cord-103204-gt6upfri 54 8 be be VB cord-103204-gt6upfri 54 9 taken take VBN cord-103204-gt6upfri 54 10 into into IN cord-103204-gt6upfri 54 11 account account NN cord-103204-gt6upfri 54 12 and and CC cord-103204-gt6upfri 54 13 are be VBP cord-103204-gt6upfri 54 14 marked mark VBN cord-103204-gt6upfri 54 15 in in IN cord-103204-gt6upfri 54 16 the the DT cord-103204-gt6upfri 54 17 final final JJ cord-103204-gt6upfri 54 18 output output NN cord-103204-gt6upfri 54 19 , , , cord-103204-gt6upfri 54 20 as as IN cord-103204-gt6upfri 54 21 they -PRON- PRP cord-103204-gt6upfri 54 22 might may MD cord-103204-gt6upfri 54 23 not not RB cord-103204-gt6upfri 54 24 occur occur VB cord-103204-gt6upfri 54 25 from from IN cord-103204-gt6upfri 54 26 real real JJ cord-103204-gt6upfri 54 27 recombination recombination NN cord-103204-gt6upfri 54 28 events event NNS cord-103204-gt6upfri 54 29 . . . cord-103204-gt6upfri 55 1 Positions position NNS cord-103204-gt6upfri 55 2 of of IN cord-103204-gt6upfri 55 3 putative putative JJ cord-103204-gt6upfri 55 4 breakpoints breakpoint NNS cord-103204-gt6upfri 55 5 that that WDT cord-103204-gt6upfri 55 6 would would MD cord-103204-gt6upfri 55 7 destroy destroy VB cord-103204-gt6upfri 55 8 the the DT cord-103204-gt6upfri 55 9 open open JJ cord-103204-gt6upfri 55 10 reading reading NN cord-103204-gt6upfri 55 11 frame frame NN cord-103204-gt6upfri 55 12 are be VBP cord-103204-gt6upfri 55 13 adjusted adjust VBN cord-103204-gt6upfri 55 14 to to IN cord-103204-gt6upfri 55 15 the the DT cord-103204-gt6upfri 55 16 next next JJ cord-103204-gt6upfri 55 17 valid valid JJ cord-103204-gt6upfri 55 18 position position NN cord-103204-gt6upfri 55 19 . . . cord-103204-gt6upfri 56 1 Phylogenetic phylogenetic JJ cord-103204-gt6upfri 56 2 reconstructions reconstruction NNS cord-103204-gt6upfri 56 3 on on IN cord-103204-gt6upfri 56 4 the the DT cord-103204-gt6upfri 56 5 full full JJ cord-103204-gt6upfri 56 6 alignment alignment NN cord-103204-gt6upfri 56 7 and and CC cord-103204-gt6upfri 56 8 all all DT cord-103204-gt6upfri 56 9 fragments fragment NNS cord-103204-gt6upfri 56 10 are be VBP cord-103204-gt6upfri 56 11 performed perform VBN cord-103204-gt6upfri 56 12 with with IN cord-103204-gt6upfri 56 13 RAxML RAxML NNS cord-103204-gt6upfri 56 14 ( ( -LRB- cord-103204-gt6upfri 56 15 v8.2.12 v8.2.12 NN cord-103204-gt6upfri 56 16 ) ) -RRB- cord-103204-gt6upfri 56 17 ( ( -LRB- cord-103204-gt6upfri 56 18 Stamatakis Stamatakis NNP cord-103204-gt6upfri 56 19 , , , cord-103204-gt6upfri 56 20 2014 2014 CD cord-103204-gt6upfri 56 21 ) ) -RRB- cord-103204-gt6upfri 56 22 using use VBG cord-103204-gt6upfri 56 23 the the DT cord-103204-gt6upfri 56 24 GTRGAMMA GTRGAMMA NNP cord-103204-gt6upfri 56 25 model model NN cord-103204-gt6upfri 56 26 for for IN cord-103204-gt6upfri 56 27 nucleotide nucleotide JJ cord-103204-gt6upfri 56 28 sequences sequence NNS cord-103204-gt6upfri 56 29 and and CC cord-103204-gt6upfri 56 30 PROTGAMMAWAG PROTGAMMAWAG NNP cord-103204-gt6upfri 56 31 for for IN cord-103204-gt6upfri 56 32 amino amino JJ cord-103204-gt6upfri 56 33 acids acid NNS cord-103204-gt6upfri 56 34 . . . cord-103204-gt6upfri 57 1 All all DT cord-103204-gt6upfri 57 2 calculations calculation NNS cord-103204-gt6upfri 57 3 are be VBP cord-103204-gt6upfri 57 4 performed perform VBN cord-103204-gt6upfri 57 5 with with IN cord-103204-gt6upfri 57 6 1 1 CD cord-103204-gt6upfri 57 7 000 000 CD cord-103204-gt6upfri 57 8 bootstrap bootstrap NN cord-103204-gt6upfri 57 9 replicates replicate NNS cord-103204-gt6upfri 57 10 . . . cord-103204-gt6upfri 58 1 The the DT cord-103204-gt6upfri 58 2 user user NN cord-103204-gt6upfri 58 3 can can MD cord-103204-gt6upfri 58 4 apply apply VB cord-103204-gt6upfri 58 5 optional optional JJ cord-103204-gt6upfri 58 6 outgroup outgroup NN cord-103204-gt6upfri 58 7 rooting rooting NN cord-103204-gt6upfri 58 8 . . . cord-103204-gt6upfri 59 1 The the DT cord-103204-gt6upfri 59 2 Newick Newick NNP cord-103204-gt6upfri 59 3 Utilities Utilities NNPS cord-103204-gt6upfri 59 4 suite suite NN cord-103204-gt6upfri 59 5 ( ( -LRB- cord-103204-gt6upfri 59 6 v1.6 v1.6 NNS cord-103204-gt6upfri 59 7 ) ) -RRB- cord-103204-gt6upfri 59 8 ( ( -LRB- cord-103204-gt6upfri 59 9 Junier Junier NNP cord-103204-gt6upfri 59 10 and and CC cord-103204-gt6upfri 59 11 Zdobnov Zdobnov NNP cord-103204-gt6upfri 59 12 , , , cord-103204-gt6upfri 59 13 2010 2010 CD cord-103204-gt6upfri 59 14 ) ) -RRB- cord-103204-gt6upfri 59 15 is be VBZ cord-103204-gt6upfri 59 16 used use VBN cord-103204-gt6upfri 59 17 to to TO cord-103204-gt6upfri 59 18 visualize visualize VB cord-103204-gt6upfri 59 19 the the DT cord-103204-gt6upfri 59 20 calculated calculate VBN cord-103204-gt6upfri 59 21 trees tree NNS cord-103204-gt6upfri 59 22 in in IN cord-103204-gt6upfri 59 23 different different JJ cord-103204-gt6upfri 59 24 formats format NNS cord-103204-gt6upfri 59 25 . . . cord-103204-gt6upfri 60 1 Positive positive JJ cord-103204-gt6upfri 60 2 selection selection NN cord-103204-gt6upfri 60 3 is be VBZ cord-103204-gt6upfri 60 4 analyzed analyze VBN cord-103204-gt6upfri 60 5 on on IN cord-103204-gt6upfri 60 6 the the DT cord-103204-gt6upfri 60 7 full full JJ cord-103204-gt6upfri 60 8 alignment alignment NN cord-103204-gt6upfri 60 9 and and CC cord-103204-gt6upfri 60 10 each each DT cord-103204-gt6upfri 60 11 of of IN cord-103204-gt6upfri 60 12 the the DT cord-103204-gt6upfri 60 13 fragments fragment NNS cord-103204-gt6upfri 60 14 separately separately RB cord-103204-gt6upfri 60 15 . . . cord-103204-gt6upfri 61 1 Maximum maximum JJ cord-103204-gt6upfri 61 2 - - HYPH cord-103204-gt6upfri 61 3 likelihood likelihood NN cord-103204-gt6upfri 61 4 tests test NNS cord-103204-gt6upfri 61 5 to to TO cord-103204-gt6upfri 61 6 detect detect VB cord-103204-gt6upfri 61 7 positive positive JJ cord-103204-gt6upfri 61 8 selection selection NN cord-103204-gt6upfri 61 9 under under IN cord-103204-gt6upfri 61 10 varying vary VBG cord-103204-gt6upfri 61 11 site site NN cord-103204-gt6upfri 61 12 models model NNS cord-103204-gt6upfri 61 13 are be VBP cord-103204-gt6upfri 61 14 performed perform VBN cord-103204-gt6upfri 61 15 with with IN cord-103204-gt6upfri 61 16 CODEML CODEML NNP cord-103204-gt6upfri 61 17 ( ( -LRB- cord-103204-gt6upfri 61 18 M1a M1a NNP cord-103204-gt6upfri 61 19 vs. vs. IN cord-103204-gt6upfri 61 20 M2a M2a NNP cord-103204-gt6upfri 61 21 , , , cord-103204-gt6upfri 61 22 M7 m7 NN cord-103204-gt6upfri 61 23 vs. vs. FW cord-103204-gt6upfri 61 24 M8 M8 NNP cord-103204-gt6upfri 61 25 ) ) -RRB- cord-103204-gt6upfri 61 26 implemented implement VBD cord-103204-gt6upfri 61 27 within within IN cord-103204-gt6upfri 61 28 the the DT cord-103204-gt6upfri 61 29 PAML PAML NNP cord-103204-gt6upfri 61 30 suite suite NN cord-103204-gt6upfri 61 31 ( ( -LRB- cord-103204-gt6upfri 61 32 v4.9 v4.9 NNP cord-103204-gt6upfri 61 33 ) ) -RRB- cord-103204-gt6upfri 61 34 ( ( -LRB- cord-103204-gt6upfri 61 35 Yang Yang NNP cord-103204-gt6upfri 61 36 , , , cord-103204-gt6upfri 61 37 2007 2007 CD cord-103204-gt6upfri 61 38 ) ) -RRB- cord-103204-gt6upfri 61 39 . . . cord-103204-gt6upfri 62 1 Furthermore furthermore RB cord-103204-gt6upfri 62 2 , , , cord-103204-gt6upfri 62 3 we -PRON- PRP cord-103204-gt6upfri 62 4 implemented implement VBD cord-103204-gt6upfri 62 5 the the DT cord-103204-gt6upfri 62 6 M8a M8a NNP cord-103204-gt6upfri 62 7 vs. vs. CC cord-103204-gt6upfri 62 8 M8 m8 NN cord-103204-gt6upfri 62 9 test test NN cord-103204-gt6upfri 62 10 proposed propose VBN cord-103204-gt6upfri 62 11 by by IN cord-103204-gt6upfri 62 12 Swanson Swanson NNP cord-103204-gt6upfri 62 13 et et NNP cord-103204-gt6upfri 62 14 al al NNP cord-103204-gt6upfri 62 15 . . . cord-103204-gt6upfri 63 1 ( ( -LRB- cord-103204-gt6upfri 63 2 2003 2003 CD cord-103204-gt6upfri 63 3 ) ) -RRB- cord-103204-gt6upfri 63 4 as as IN cord-103204-gt6upfri 63 5 an an DT cord-103204-gt6upfri 63 6 additional additional JJ cord-103204-gt6upfri 63 7 model model NN cord-103204-gt6upfri 63 8 test test NN cord-103204-gt6upfri 63 9 in in IN cord-103204-gt6upfri 63 10 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 63 11 . . . cord-103204-gt6upfri 64 1 The the DT cord-103204-gt6upfri 64 2 different different JJ cord-103204-gt6upfri 64 3 statistical statistical JJ cord-103204-gt6upfri 64 4 site site NN cord-103204-gt6upfri 64 5 models model NNS cord-103204-gt6upfri 64 6 that that WDT cord-103204-gt6upfri 64 7 do do VBP cord-103204-gt6upfri 64 8 not not RB cord-103204-gt6upfri 64 9 allow allow VB cord-103204-gt6upfri 64 10 ( ( -LRB- cord-103204-gt6upfri 64 11 neutral neutral JJ cord-103204-gt6upfri 64 12 models model NNS cord-103204-gt6upfri 64 13 ) ) -RRB- cord-103204-gt6upfri 64 14 or or CC cord-103204-gt6upfri 64 15 allow allow VB cord-103204-gt6upfri 64 16 ( ( -LRB- cord-103204-gt6upfri 64 17 selection selection NN cord-103204-gt6upfri 64 18 models model NNS cord-103204-gt6upfri 64 19 ) ) -RRB- cord-103204-gt6upfri 64 20 a a DT cord-103204-gt6upfri 64 21 class class NN cord-103204-gt6upfri 64 22 of of IN cord-103204-gt6upfri 64 23 codons codon NNS cord-103204-gt6upfri 64 24 to to TO cord-103204-gt6upfri 64 25 evolve evolve VB cord-103204-gt6upfri 64 26 with with IN cord-103204-gt6upfri 64 27 ω ω NN cord-103204-gt6upfri 64 28 > > XX cord-103204-gt6upfri 65 1 1 1 CD cord-103204-gt6upfri 65 2 are be VBP cord-103204-gt6upfri 65 3 compared compare VBN cord-103204-gt6upfri 65 4 . . . cord-103204-gt6upfri 66 1 Furthermore furthermore RB cord-103204-gt6upfri 66 2 , , , cord-103204-gt6upfri 66 3 varying vary VBG cord-103204-gt6upfri 66 4 codon codon NN cord-103204-gt6upfri 66 5 frequency frequency NN cord-103204-gt6upfri 66 6 models model NNS cord-103204-gt6upfri 66 7 are be VBP cord-103204-gt6upfri 66 8 applied apply VBN cord-103204-gt6upfri 66 9 to to TO cord-103204-gt6upfri 66 10 simulate simulate VB cord-103204-gt6upfri 66 11 different different JJ cord-103204-gt6upfri 66 12 nucleotide nucleotide JJ cord-103204-gt6upfri 66 13 substitution substitution NN cord-103204-gt6upfri 66 14 rates rate NNS cord-103204-gt6upfri 66 15 . . . cord-103204-gt6upfri 67 1 A a DT cord-103204-gt6upfri 67 2 gene gene NN cord-103204-gt6upfri 67 3 is be VBZ cord-103204-gt6upfri 67 4 declared declare VBN cord-103204-gt6upfri 67 5 to to TO cord-103204-gt6upfri 67 6 be be VB cord-103204-gt6upfri 67 7 positively positively RB cord-103204-gt6upfri 67 8 selected select VBN cord-103204-gt6upfri 67 9 if if IN cord-103204-gt6upfri 67 10 the the DT cord-103204-gt6upfri 67 11 neutral neutral JJ cord-103204-gt6upfri 67 12 model model NN cord-103204-gt6upfri 67 13 can can MD cord-103204-gt6upfri 67 14 be be VB cord-103204-gt6upfri 67 15 rejected reject VBN cord-103204-gt6upfri 67 16 in in IN cord-103204-gt6upfri 67 17 favor favor NN cord-103204-gt6upfri 67 18 of of IN cord-103204-gt6upfri 67 19 the the DT cord-103204-gt6upfri 67 20 positive positive JJ cord-103204-gt6upfri 67 21 selection selection NN cord-103204-gt6upfri 67 22 model model NN cord-103204-gt6upfri 67 23 based base VBN cord-103204-gt6upfri 67 24 on on IN cord-103204-gt6upfri 67 25 a a DT cord-103204-gt6upfri 67 26 likelihood likelihood NN cord-103204-gt6upfri 67 27 ratio ratio NN cord-103204-gt6upfri 67 28 test test NN cord-103204-gt6upfri 67 29 . . . cord-103204-gt6upfri 68 1 Then then RB cord-103204-gt6upfri 68 2 , , , cord-103204-gt6upfri 68 3 a a DT cord-103204-gt6upfri 68 4 Bayes Bayes NNP cord-103204-gt6upfri 68 5 empirical empirical JJ cord-103204-gt6upfri 68 6 Bayes Bayes NNP cord-103204-gt6upfri 68 7 ( ( -LRB- cord-103204-gt6upfri 68 8 BEB BEB NNP cord-103204-gt6upfri 68 9 ) ) -RRB- cord-103204-gt6upfri 68 10 approach approach NN cord-103204-gt6upfri 69 1 ( ( -LRB- cord-103204-gt6upfri 69 2 Yang Yang NNP cord-103204-gt6upfri 69 3 et et NNP cord-103204-gt6upfri 69 4 al al NNP cord-103204-gt6upfri 69 5 . . NNP cord-103204-gt6upfri 69 6 , , , cord-103204-gt6upfri 69 7 2005 2005 CD cord-103204-gt6upfri 69 8 ) ) -RRB- cord-103204-gt6upfri 69 9 is be VBZ cord-103204-gt6upfri 69 10 applied apply VBN cord-103204-gt6upfri 69 11 to to TO cord-103204-gt6upfri 69 12 calculate calculate VB cord-103204-gt6upfri 69 13 posterior posterior JJ cord-103204-gt6upfri 69 14 probabilities probability NNS cord-103204-gt6upfri 69 15 ( ( -LRB- cord-103204-gt6upfri 69 16 P p NN cord-103204-gt6upfri 69 17 P p NN cord-103204-gt6upfri 69 18 ) ) -RRB- cord-103204-gt6upfri 69 19 that that IN cord-103204-gt6upfri 69 20 a a DT cord-103204-gt6upfri 69 21 codon codon NN cord-103204-gt6upfri 69 22 comes come VBZ cord-103204-gt6upfri 69 23 from from IN cord-103204-gt6upfri 69 24 the the DT cord-103204-gt6upfri 69 25 site site NN cord-103204-gt6upfri 69 26 class class NN cord-103204-gt6upfri 69 27 with with IN cord-103204-gt6upfri 69 28 ω ω ADD cord-103204-gt6upfri 70 1 > > XX cord-103204-gt6upfri 70 2 1 1 CD cord-103204-gt6upfri 70 3 . . . cord-103204-gt6upfri 71 1 Positively positively RB cord-103204-gt6upfri 71 2 selected select VBN cord-103204-gt6upfri 71 3 sites site NNS cord-103204-gt6upfri 71 4 with with IN cord-103204-gt6upfri 71 5 an an DT cord-103204-gt6upfri 71 6 assigned assigned JJ cord-103204-gt6upfri 71 7 P p NN cord-103204-gt6upfri 71 8 P p NN cord-103204-gt6upfri 71 9 > > XX cord-103204-gt6upfri 71 10 0.95 0.95 CD cord-103204-gt6upfri 71 11 are be VBP cord-103204-gt6upfri 71 12 depicted depict VBN cord-103204-gt6upfri 71 13 as as IN cord-103204-gt6upfri 71 14 significant significant JJ cord-103204-gt6upfri 71 15 . . . cord-103204-gt6upfri 72 1 We -PRON- PRP cord-103204-gt6upfri 72 2 graphically graphically RB cord-103204-gt6upfri 72 3 summarize summarize VBP cord-103204-gt6upfri 72 4 all all DT cord-103204-gt6upfri 72 5 positively positively RB cord-103204-gt6upfri 72 6 selected select VBN cord-103204-gt6upfri 72 7 sites site NNS cord-103204-gt6upfri 72 8 under under IN cord-103204-gt6upfri 72 9 varying vary VBG cord-103204-gt6upfri 72 10 frequency frequency NN cord-103204-gt6upfri 72 11 models model NNS cord-103204-gt6upfri 72 12 in in IN cord-103204-gt6upfri 72 13 the the DT cord-103204-gt6upfri 72 14 output output NN cord-103204-gt6upfri 72 15 ( ( -LRB- cord-103204-gt6upfri 72 16 Fig Fig NNP cord-103204-gt6upfri 72 17 . . . cord-103204-gt6upfri 72 18 1 1 CD cord-103204-gt6upfri 72 19 ) ) -RRB- cord-103204-gt6upfri 72 20 . . . cord-103204-gt6upfri 73 1 Thus thus RB cord-103204-gt6upfri 73 2 , , , cord-103204-gt6upfri 73 3 we -PRON- PRP cord-103204-gt6upfri 73 4 allow allow VBP cord-103204-gt6upfri 73 5 the the DT cord-103204-gt6upfri 73 6 user user NN cord-103204-gt6upfri 73 7 to to TO cord-103204-gt6upfri 73 8 investigate investigate VB cord-103204-gt6upfri 73 9 sites site NNS cord-103204-gt6upfri 73 10 that that WDT cord-103204-gt6upfri 73 11 would would MD cord-103204-gt6upfri 73 12 be be VB cord-103204-gt6upfri 73 13 dismissed dismiss VBN cord-103204-gt6upfri 73 14 from from IN cord-103204-gt6upfri 73 15 the the DT cord-103204-gt6upfri 73 16 output output NN cord-103204-gt6upfri 73 17 when when WRB cord-103204-gt6upfri 73 18 using use VBG cord-103204-gt6upfri 73 19 a a DT cord-103204-gt6upfri 73 20 P p NN cord-103204-gt6upfri 73 21 P p NN cord-103204-gt6upfri 73 22 threshold threshold NN cord-103204-gt6upfri 73 23 . . . cord-103204-gt6upfri 74 1 For for IN cord-103204-gt6upfri 74 2 example example NN cord-103204-gt6upfri 74 3 , , , cord-103204-gt6upfri 74 4 such such JJ cord-103204-gt6upfri 74 5 sites site NNS cord-103204-gt6upfri 74 6 could could MD cord-103204-gt6upfri 74 7 be be VB cord-103204-gt6upfri 74 8 located locate VBN cord-103204-gt6upfri 74 9 in in IN cord-103204-gt6upfri 74 10 regulatory regulatory JJ cord-103204-gt6upfri 74 11 domains domain NNS cord-103204-gt6upfri 74 12 of of IN cord-103204-gt6upfri 74 13 the the DT cord-103204-gt6upfri 74 14 final final JJ cord-103204-gt6upfri 74 15 protein protein NN cord-103204-gt6upfri 74 16 , , , cord-103204-gt6upfri 74 17 yielding yield VBG cord-103204-gt6upfri 74 18 a a DT cord-103204-gt6upfri 74 19 lower low JJR cord-103204-gt6upfri 74 20 P p NN cord-103204-gt6upfri 74 21 P p NN cord-103204-gt6upfri 74 22 value value NN cord-103204-gt6upfri 74 23 due due IN cord-103204-gt6upfri 74 24 to to IN cord-103204-gt6upfri 74 25 insufficient insufficient JJ cord-103204-gt6upfri 74 26 species species NN cord-103204-gt6upfri 74 27 sampling sampling NN cord-103204-gt6upfri 74 28 ( ( -LRB- cord-103204-gt6upfri 74 29 McBee McBee NNP cord-103204-gt6upfri 74 30 et et NNP cord-103204-gt6upfri 74 31 al al NNP cord-103204-gt6upfri 74 32 . . NNP cord-103204-gt6upfri 74 33 , , , cord-103204-gt6upfri 74 34 2015 2015 CD cord-103204-gt6upfri 74 35 ) ) -RRB- cord-103204-gt6upfri 74 36 . . . cord-103204-gt6upfri 75 1 The the DT cord-103204-gt6upfri 75 2 final final JJ cord-103204-gt6upfri 75 3 output output NN cord-103204-gt6upfri 75 4 of of IN cord-103204-gt6upfri 75 5 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 75 6 is be VBZ cord-103204-gt6upfri 75 7 based base VBN cord-103204-gt6upfri 75 8 on on IN cord-103204-gt6upfri 75 9 a a DT cord-103204-gt6upfri 75 10 heavily heavily RB cord-103204-gt6upfri 75 11 modified modify VBN cord-103204-gt6upfri 75 12 version version NN cord-103204-gt6upfri 75 13 of of IN cord-103204-gt6upfri 75 14 the the DT cord-103204-gt6upfri 75 15 TranslatorX TranslatorX NNP cord-103204-gt6upfri 75 16 HTML html NN cord-103204-gt6upfri 75 17 output output NN cord-103204-gt6upfri 75 18 . . . cord-103204-gt6upfri 76 1 The the DT cord-103204-gt6upfri 76 2 amino amino NN cord-103204-gt6upfri 76 3 acid acid NN cord-103204-gt6upfri 76 4 color color NN cord-103204-gt6upfri 76 5 code code NN cord-103204-gt6upfri 76 6 is be VBZ cord-103204-gt6upfri 76 7 adapted adapt VBN cord-103204-gt6upfri 76 8 from from IN cord-103204-gt6upfri 76 9 TranslatorX. TranslatorX. NNS cord-103204-gt6upfri 77 1 Here here RB cord-103204-gt6upfri 77 2 we -PRON- PRP cord-103204-gt6upfri 77 3 present present VBP cord-103204-gt6upfri 77 4 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 77 5 , , , cord-103204-gt6upfri 77 6 an an DT cord-103204-gt6upfri 77 7 easy easy JJ cord-103204-gt6upfri 77 8 - - HYPH cord-103204-gt6upfri 77 9 to to TO cord-103204-gt6upfri 77 10 - - HYPH cord-103204-gt6upfri 77 11 use use NN cord-103204-gt6upfri 77 12 Nextflow Nextflow NNP cord-103204-gt6upfri 77 13 pipeline pipeline NN cord-103204-gt6upfri 77 14 for for IN cord-103204-gt6upfri 77 15 the the DT cord-103204-gt6upfri 77 16 accurate accurate JJ cord-103204-gt6upfri 77 17 detection detection NN cord-103204-gt6upfri 77 18 of of IN cord-103204-gt6upfri 77 19 site site NN cord-103204-gt6upfri 77 20 - - HYPH cord-103204-gt6upfri 77 21 specific specific JJ cord-103204-gt6upfri 77 22 positive positive JJ cord-103204-gt6upfri 77 23 selection selection NN cord-103204-gt6upfri 77 24 and and CC cord-103204-gt6upfri 77 25 recombination recombination NN cord-103204-gt6upfri 77 26 events event NNS cord-103204-gt6upfri 77 27 in in IN cord-103204-gt6upfri 77 28 protein protein NN cord-103204-gt6upfri 77 29 - - HYPH cord-103204-gt6upfri 77 30 coding code VBG cord-103204-gt6upfri 77 31 sequences sequence NNS cord-103204-gt6upfri 77 32 . . . cord-103204-gt6upfri 78 1 The the DT cord-103204-gt6upfri 78 2 input input NN cord-103204-gt6upfri 78 3 is be VBZ cord-103204-gt6upfri 78 4 a a DT cord-103204-gt6upfri 78 5 multiple multiple JJ cord-103204-gt6upfri 78 6 FASTA FASTA NNP cord-103204-gt6upfri 78 7 file file NN cord-103204-gt6upfri 78 8 of of IN cord-103204-gt6upfri 78 9 homologous homologous JJ cord-103204-gt6upfri 78 10 coding coding NN cord-103204-gt6upfri 78 11 sequences sequence NNS cord-103204-gt6upfri 78 12 that that WDT cord-103204-gt6upfri 78 13 is be VBZ cord-103204-gt6upfri 78 14 automatically automatically RB cord-103204-gt6upfri 78 15 transferred transfer VBN cord-103204-gt6upfri 78 16 into into IN cord-103204-gt6upfri 78 17 a a DT cord-103204-gt6upfri 78 18 codon codon NN cord-103204-gt6upfri 78 19 - - HYPH cord-103204-gt6upfri 78 20 based base VBN cord-103204-gt6upfri 78 21 alignment alignment NN cord-103204-gt6upfri 78 22 . . . cord-103204-gt6upfri 79 1 Since since IN cord-103204-gt6upfri 79 2 recombination recombination NN cord-103204-gt6upfri 79 3 can can MD cord-103204-gt6upfri 79 4 have have VB cord-103204-gt6upfri 79 5 a a DT cord-103204-gt6upfri 79 6 profound profound JJ cord-103204-gt6upfri 79 7 impact impact NN cord-103204-gt6upfri 79 8 on on IN cord-103204-gt6upfri 79 9 the the DT cord-103204-gt6upfri 79 10 evolutionary evolutionary JJ cord-103204-gt6upfri 79 11 history history NN cord-103204-gt6upfri 79 12 of of IN cord-103204-gt6upfri 79 13 sequences sequence NNS cord-103204-gt6upfri 79 14 , , , cord-103204-gt6upfri 79 15 we -PRON- PRP cord-103204-gt6upfri 79 16 initially initially RB cord-103204-gt6upfri 79 17 check check VBP cord-103204-gt6upfri 79 18 the the DT cord-103204-gt6upfri 79 19 alignment alignment NN cord-103204-gt6upfri 79 20 for for IN cord-103204-gt6upfri 79 21 topological topological JJ cord-103204-gt6upfri 79 22 incongruence incongruence NN cord-103204-gt6upfri 79 23 to to TO cord-103204-gt6upfri 79 24 define define VB cord-103204-gt6upfri 79 25 putative putative JJ cord-103204-gt6upfri 79 26 recombination recombination NN cord-103204-gt6upfri 79 27 breakpoints breakpoint NNS cord-103204-gt6upfri 79 28 . . . cord-103204-gt6upfri 80 1 The the DT cord-103204-gt6upfri 80 2 whole whole JJ cord-103204-gt6upfri 80 3 evolutionary evolutionary JJ cord-103204-gt6upfri 80 4 analysis analysis NN cord-103204-gt6upfri 80 5 of of IN cord-103204-gt6upfri 80 6 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 80 7 is be VBZ cord-103204-gt6upfri 80 8 performed perform VBN cord-103204-gt6upfri 80 9 independently independently RB cord-103204-gt6upfri 80 10 for for IN cord-103204-gt6upfri 80 11 the the DT cord-103204-gt6upfri 80 12 full full JJ cord-103204-gt6upfri 80 13 alignment alignment NN cord-103204-gt6upfri 80 14 and and CC cord-103204-gt6upfri 80 15 all all DT cord-103204-gt6upfri 80 16 possible possible JJ cord-103204-gt6upfri 80 17 fragments fragment NNS cord-103204-gt6upfri 80 18 . . . cord-103204-gt6upfri 81 1 PoSeiDon PoSeiDon NNP cord-103204-gt6upfri 81 2 automatically automatically RB cord-103204-gt6upfri 81 3 calculates calculate VBZ cord-103204-gt6upfri 81 4 maximum maximum JJ cord-103204-gt6upfri 81 5 likelihood likelihood NN cord-103204-gt6upfri 81 6 - - HYPH cord-103204-gt6upfri 81 7 based base VBN cord-103204-gt6upfri 81 8 phylogenetic phylogenetic NN cord-103204-gt6upfri 81 9 trees tree NNS cord-103204-gt6upfri 81 10 for for IN cord-103204-gt6upfri 81 11 all all DT cord-103204-gt6upfri 81 12 alignments alignment NNS cord-103204-gt6upfri 81 13 , , , cord-103204-gt6upfri 81 14 estimates estimate VBZ cord-103204-gt6upfri 81 15 ω ω NN cord-103204-gt6upfri 81 16 values value NNS cord-103204-gt6upfri 81 17 at at IN cord-103204-gt6upfri 81 18 each each DT cord-103204-gt6upfri 81 19 site site NN cord-103204-gt6upfri 81 20 , , , cord-103204-gt6upfri 81 21 and and CC cord-103204-gt6upfri 81 22 computes compute VBZ cord-103204-gt6upfri 81 23 their -PRON- PRP$ cord-103204-gt6upfri 81 24 impact impact NN cord-103204-gt6upfri 81 25 on on IN cord-103204-gt6upfri 81 26 the the DT cord-103204-gt6upfri 81 27 positive positive JJ cord-103204-gt6upfri 81 28 selection selection NN cord-103204-gt6upfri 81 29 . . . cord-103204-gt6upfri 82 1 All all DT cord-103204-gt6upfri 82 2 identified identify VBN cord-103204-gt6upfri 82 3 sites site NNS cord-103204-gt6upfri 82 4 and and CC cord-103204-gt6upfri 82 5 their -PRON- PRP$ cord-103204-gt6upfri 82 6 significance significance NN cord-103204-gt6upfri 82 7 values value NNS cord-103204-gt6upfri 82 8 are be VBP cord-103204-gt6upfri 82 9 projected project VBN cord-103204-gt6upfri 82 10 onto onto IN cord-103204-gt6upfri 82 11 the the DT cord-103204-gt6upfri 82 12 codon codon NN cord-103204-gt6upfri 82 13 and and CC cord-103204-gt6upfri 82 14 amino amino NN cord-103204-gt6upfri 82 15 acid acid NN cord-103204-gt6upfri 82 16 alignment alignment NN cord-103204-gt6upfri 82 17 of of IN cord-103204-gt6upfri 82 18 the the DT cord-103204-gt6upfri 82 19 input input NN cord-103204-gt6upfri 82 20 sequences sequence NNS cord-103204-gt6upfri 82 21 to to TO cord-103204-gt6upfri 82 22 allow allow VB cord-103204-gt6upfri 82 23 visual visual JJ cord-103204-gt6upfri 82 24 identification identification NN cord-103204-gt6upfri 82 25 of of IN cord-103204-gt6upfri 82 26 evolutionary evolutionary JJ cord-103204-gt6upfri 82 27 hot hot JJ cord-103204-gt6upfri 82 28 - - HYPH cord-103204-gt6upfri 82 29 spots spot NNS cord-103204-gt6upfri 82 30 with with IN cord-103204-gt6upfri 82 31 high high JJ cord-103204-gt6upfri 82 32 ω ω CD cord-103204-gt6upfri 82 33 values value NNS cord-103204-gt6upfri 82 34 . . . cord-103204-gt6upfri 83 1 Additionally additionally RB cord-103204-gt6upfri 83 2 , , , cord-103204-gt6upfri 83 3 publication publication NN cord-103204-gt6upfri 83 4 - - HYPH cord-103204-gt6upfri 83 5 ready ready JJ cord-103204-gt6upfri 83 6 PDF PDF NNP cord-103204-gt6upfri 83 7 and and CC cord-103204-gt6upfri 83 8 L L NNP cord-103204-gt6upfri 83 9 A A NNP cord-103204-gt6upfri 83 10 T t NN cord-103204-gt6upfri 83 11 E e NN cord-103204-gt6upfri 83 12 X x NN cord-103204-gt6upfri 83 13 tables table NNS cord-103204-gt6upfri 83 14 are be VBP cord-103204-gt6upfri 83 15 provided provide VBN cord-103204-gt6upfri 83 16 , , , cord-103204-gt6upfri 83 17 including include VBG cord-103204-gt6upfri 83 18 all all DT cord-103204-gt6upfri 83 19 breakpoints breakpoint NNS cord-103204-gt6upfri 83 20 and and CC cord-103204-gt6upfri 83 21 significantly significantly RB cord-103204-gt6upfri 83 22 positively positively RB cord-103204-gt6upfri 83 23 selected select VBN cord-103204-gt6upfri 83 24 sites site NNS cord-103204-gt6upfri 83 25 . . . cord-103204-gt6upfri 84 1 All all DT cord-103204-gt6upfri 84 2 results result NNS cord-103204-gt6upfri 84 3 are be VBP cord-103204-gt6upfri 84 4 summarized summarize VBN cord-103204-gt6upfri 84 5 in in IN cord-103204-gt6upfri 84 6 a a DT cord-103204-gt6upfri 84 7 userfriendly userfriendly JJ cord-103204-gt6upfri 84 8 and and CC cord-103204-gt6upfri 84 9 clear clear JJ cord-103204-gt6upfri 84 10 manner manner NN cord-103204-gt6upfri 84 11 , , , cord-103204-gt6upfri 84 12 allowing allow VBG cord-103204-gt6upfri 84 13 researchers researcher NNS cord-103204-gt6upfri 84 14 to to TO cord-103204-gt6upfri 84 15 study study VB cord-103204-gt6upfri 84 16 positive positive JJ cord-103204-gt6upfri 84 17 selection selection NN cord-103204-gt6upfri 84 18 . . . cord-103204-gt6upfri 85 1 Funding funding NN cord-103204-gt6upfri 85 2 : : : cord-103204-gt6upfri 86 1 This this DT cord-103204-gt6upfri 86 2 work work NN cord-103204-gt6upfri 86 3 has have VBZ cord-103204-gt6upfri 86 4 been be VBN cord-103204-gt6upfri 86 5 supported support VBN cord-103204-gt6upfri 86 6 by by IN cord-103204-gt6upfri 86 7 the the DT cord-103204-gt6upfri 86 8 Deutsche Deutsche NNP cord-103204-gt6upfri 86 9 Forschungsgemeinschaft Forschungsgemeinschaft NNP cord-103204-gt6upfri 86 10 ( ( -LRB- cord-103204-gt6upfri 86 11 DFG DFG NNP cord-103204-gt6upfri 86 12 ) ) -RRB- cord-103204-gt6upfri 86 13 through through IN cord-103204-gt6upfri 86 14 the the DT cord-103204-gt6upfri 86 15 Priority Priority NNP cord-103204-gt6upfri 86 16 Program Program NNP cord-103204-gt6upfri 87 1 SPP-1596 SPP-1596 NNP cord-103204-gt6upfri 88 1 MA5082/7 MA5082/7 NNP cord-103204-gt6upfri 88 2 - - SYM cord-103204-gt6upfri 88 3 1 1 CD cord-103204-gt6upfri 89 1 and and CC cord-103204-gt6upfri 89 2 was be VBD cord-103204-gt6upfri 89 3 partly partly RB cord-103204-gt6upfri 89 4 conducted conduct VBN cord-103204-gt6upfri 89 5 within within IN cord-103204-gt6upfri 89 6 the the DT cord-103204-gt6upfri 89 7 Collaborative Collaborative NNP cord-103204-gt6upfri 89 8 Research Research NNP cord-103204-gt6upfri 89 9 Centre Centre NNP cord-103204-gt6upfri 89 10 AquaDiva AquaDiva NNP cord-103204-gt6upfri 89 11 ( ( -LRB- cord-103204-gt6upfri 89 12 CRC CRC NNP cord-103204-gt6upfri 89 13 1076 1076 CD cord-103204-gt6upfri 89 14 AquaDiva AquaDiva NNP cord-103204-gt6upfri 89 15 ) ) -RRB- cord-103204-gt6upfri 89 16 of of IN cord-103204-gt6upfri 89 17 the the DT cord-103204-gt6upfri 89 18 Friedrich Friedrich NNP cord-103204-gt6upfri 89 19 Schiller Schiller NNP cord-103204-gt6upfri 89 20 University University NNP cord-103204-gt6upfri 89 21 Jena Jena NNP cord-103204-gt6upfri 89 22 , , , cord-103204-gt6upfri 89 23 also also RB cord-103204-gt6upfri 89 24 funded fund VBN cord-103204-gt6upfri 89 25 by by IN cord-103204-gt6upfri 89 26 the the DT cord-103204-gt6upfri 89 27 DFG DFG NNP cord-103204-gt6upfri 89 28 . . . cord-103204-gt6upfri 90 1 MH MH NNP cord-103204-gt6upfri 90 2 appreciates appreciate VBZ cord-103204-gt6upfri 90 3 the the DT cord-103204-gt6upfri 90 4 support support NN cord-103204-gt6upfri 90 5 of of IN cord-103204-gt6upfri 90 6 the the DT cord-103204-gt6upfri 90 7 Joachim Joachim NNP cord-103204-gt6upfri 90 8 Herz Herz NNP cord-103204-gt6upfri 90 9 Foundation Foundation NNP cord-103204-gt6upfri 90 10 by by IN cord-103204-gt6upfri 90 11 the the DT cord-103204-gt6upfri 90 12 addon addon NN cord-103204-gt6upfri 90 13 fellowship fellowship NN cord-103204-gt6upfri 90 14 for for IN cord-103204-gt6upfri 90 15 interdisciplinary interdisciplinary JJ cord-103204-gt6upfri 90 16 life life NN cord-103204-gt6upfri 90 17 science science NN cord-103204-gt6upfri 90 18 . . . cord-103204-gt6upfri 91 1 We -PRON- PRP cord-103204-gt6upfri 91 2 would would MD cord-103204-gt6upfri 91 3 like like VB cord-103204-gt6upfri 91 4 to to TO cord-103204-gt6upfri 91 5 thank thank VB cord-103204-gt6upfri 91 6 Lasse Lasse NNP cord-103204-gt6upfri 91 7 Faber Faber NNP cord-103204-gt6upfri 91 8 for for IN cord-103204-gt6upfri 91 9 his -PRON- PRP$ cord-103204-gt6upfri 91 10 help help NN cord-103204-gt6upfri 91 11 in in IN cord-103204-gt6upfri 91 12 implementing implement VBG cord-103204-gt6upfri 91 13 the the DT cord-103204-gt6upfri 91 14 Dockers Dockers NNPS cord-103204-gt6upfri 91 15 . . . cord-103204-gt6upfri 92 1 Conflict conflict NN cord-103204-gt6upfri 92 2 of of IN cord-103204-gt6upfri 92 3 Interest interest NN cord-103204-gt6upfri 92 4 : : : cord-103204-gt6upfri 93 1 none none NN cord-103204-gt6upfri 93 2 declared declare VBD cord-103204-gt6upfri 93 3 . . . cord-103204-gt6upfri 93 4 _SP cord-103204-gt6upfri 94 1 TranslatorX TranslatorX NNP cord-103204-gt6upfri 94 2 : : : cord-103204-gt6upfri 95 1 multiple multiple JJ cord-103204-gt6upfri 95 2 alignment alignment NN cord-103204-gt6upfri 95 3 of of IN cord-103204-gt6upfri 95 4 nucleotide nucleotide JJ cord-103204-gt6upfri 95 5 sequences sequence NNS cord-103204-gt6upfri 95 6 guided guide VBN cord-103204-gt6upfri 95 7 by by IN cord-103204-gt6upfri 95 8 amino amino NN cord-103204-gt6upfri 95 9 acid acid JJ cord-103204-gt6upfri 95 10 translations translation NNS cord-103204-gt6upfri 96 1 Datamonkey Datamonkey NNP cord-103204-gt6upfri 96 2 2010 2010 CD cord-103204-gt6upfri 96 3 : : : cord-103204-gt6upfri 96 4 a a DT cord-103204-gt6upfri 96 5 suite suite NN cord-103204-gt6upfri 96 6 of of IN cord-103204-gt6upfri 96 7 phylogenetic phylogenetic JJ cord-103204-gt6upfri 96 8 analysis analysis NN cord-103204-gt6upfri 96 9 tools tool NNS cord-103204-gt6upfri 96 10 for for IN cord-103204-gt6upfri 96 11 evolutionary evolutionary JJ cord-103204-gt6upfri 96 12 biology biology NN cord-103204-gt6upfri 97 1 Nextflow Nextflow NNP cord-103204-gt6upfri 97 2 enables enable VBZ cord-103204-gt6upfri 97 3 reproducible reproducible JJ cord-103204-gt6upfri 97 4 computational computational JJ cord-103204-gt6upfri 97 5 workflows workflow NNS cord-103204-gt6upfri 97 6 Selecton Selecton NNP cord-103204-gt6upfri 97 7 : : : cord-103204-gt6upfri 97 8 a a DT cord-103204-gt6upfri 97 9 server server NN cord-103204-gt6upfri 97 10 for for IN cord-103204-gt6upfri 97 11 detecting detect VBG cord-103204-gt6upfri 97 12 evolutionary evolutionary JJ cord-103204-gt6upfri 97 13 forces force NNS cord-103204-gt6upfri 97 14 at at IN cord-103204-gt6upfri 97 15 a a DT cord-103204-gt6upfri 97 16 single single JJ cord-103204-gt6upfri 97 17 amino amino NN cord-103204-gt6upfri 97 18 - - HYPH cord-103204-gt6upfri 97 19 acid acid NN cord-103204-gt6upfri 97 20 site site NN cord-103204-gt6upfri 97 21 MUSCLE muscle NN cord-103204-gt6upfri 97 22 : : : cord-103204-gt6upfri 98 1 multiple multiple JJ cord-103204-gt6upfri 98 2 sequence sequence NN cord-103204-gt6upfri 98 3 alignment alignment NN cord-103204-gt6upfri 98 4 with with IN cord-103204-gt6upfri 98 5 high high JJ cord-103204-gt6upfri 98 6 accuracy accuracy NN cord-103204-gt6upfri 98 7 and and CC cord-103204-gt6upfri 98 8 high high JJ cord-103204-gt6upfri 98 9 throughput throughput NN cord-103204-gt6upfri 98 10 Evolution evolution NN cord-103204-gt6upfri 98 11 and and CC cord-103204-gt6upfri 98 12 antiviral antiviral JJ cord-103204-gt6upfri 98 13 specificities specificity NNS cord-103204-gt6upfri 98 14 of of IN cord-103204-gt6upfri 98 15 interferon interferon NN cord-103204-gt6upfri 98 16 - - HYPH cord-103204-gt6upfri 98 17 induced induce VBN cord-103204-gt6upfri 98 18 Mx Mx NNP cord-103204-gt6upfri 98 19 proteins protein NNS cord-103204-gt6upfri 98 20 of of IN cord-103204-gt6upfri 98 21 bats bat NNS cord-103204-gt6upfri 98 22 against against IN cord-103204-gt6upfri 98 23 Ebola Ebola NNP cord-103204-gt6upfri 98 24 , , , cord-103204-gt6upfri 98 25 Influenza Influenza NNP cord-103204-gt6upfri 98 26 , , , cord-103204-gt6upfri 98 27 and and CC cord-103204-gt6upfri 98 28 other other JJ cord-103204-gt6upfri 98 29 RNA RNA NNP cord-103204-gt6upfri 98 30 viruses virus NNS cord-103204-gt6upfri 99 1 Signatures signature NNS cord-103204-gt6upfri 99 2 of of IN cord-103204-gt6upfri 99 3 environmental environmental JJ cord-103204-gt6upfri 99 4 genetic genetic JJ cord-103204-gt6upfri 99 5 adaptation adaptation NN cord-103204-gt6upfri 99 6 pinpoint pinpoint NN cord-103204-gt6upfri 99 7 pathogens pathogen NNS cord-103204-gt6upfri 99 8 as as IN cord-103204-gt6upfri 99 9 the the DT cord-103204-gt6upfri 99 10 main main JJ cord-103204-gt6upfri 99 11 selective selective JJ cord-103204-gt6upfri 99 12 pressure pressure NN cord-103204-gt6upfri 99 13 through through IN cord-103204-gt6upfri 99 14 human human JJ cord-103204-gt6upfri 99 15 evolution evolution NN cord-103204-gt6upfri 100 1 The the DT cord-103204-gt6upfri 100 2 Newick Newick NNP cord-103204-gt6upfri 100 3 utilities utility NNS cord-103204-gt6upfri 100 4 : : : cord-103204-gt6upfri 100 5 high high JJ cord-103204-gt6upfri 100 6 - - HYPH cord-103204-gt6upfri 100 7 throughput throughput NN cord-103204-gt6upfri 100 8 phylogenetic phylogenetic NN cord-103204-gt6upfri 100 9 tree tree NN cord-103204-gt6upfri 100 10 processing process VBG cord-103204-gt6upfri 100 11 in in IN cord-103204-gt6upfri 100 12 the the DT cord-103204-gt6upfri 100 13 UNIX UNIX NNP cord-103204-gt6upfri 100 14 shell shell NN cord-103204-gt6upfri 100 15 Evaluation Evaluation NNP cord-103204-gt6upfri 100 16 of of IN cord-103204-gt6upfri 100 17 the the DT cord-103204-gt6upfri 100 18 maximum maximum JJ cord-103204-gt6upfri 100 19 likelihood likelihood NN cord-103204-gt6upfri 100 20 estimate estimate NN cord-103204-gt6upfri 100 21 of of IN cord-103204-gt6upfri 100 22 the the DT cord-103204-gt6upfri 100 23 evolutionary evolutionary JJ cord-103204-gt6upfri 100 24 tree tree NN cord-103204-gt6upfri 100 25 topologies topology NNS cord-103204-gt6upfri 100 26 from from IN cord-103204-gt6upfri 100 27 DNA dna NN cord-103204-gt6upfri 100 28 sequence sequence NN cord-103204-gt6upfri 100 29 data data NN cord-103204-gt6upfri 100 30 , , , cord-103204-gt6upfri 100 31 and and CC cord-103204-gt6upfri 100 32 the the DT cord-103204-gt6upfri 100 33 branching branch VBG cord-103204-gt6upfri 100 34 order order NN cord-103204-gt6upfri 100 35 in in IN cord-103204-gt6upfri 100 36 Hominoidea Hominoidea NNP cord-103204-gt6upfri 101 1 The the DT cord-103204-gt6upfri 101 2 Effect Effect NNP cord-103204-gt6upfri 101 3 of of IN cord-103204-gt6upfri 101 4 Species Species NNP cord-103204-gt6upfri 101 5 Representation Representation NNP cord-103204-gt6upfri 101 6 on on IN cord-103204-gt6upfri 101 7 the the DT cord-103204-gt6upfri 101 8 Detection Detection NNP cord-103204-gt6upfri 101 9 of of IN cord-103204-gt6upfri 101 10 Positive Positive NNP cord-103204-gt6upfri 101 11 Selection Selection NNP cord-103204-gt6upfri 101 12 in in IN cord-103204-gt6upfri 101 13 Primate Primate NNP cord-103204-gt6upfri 101 14 Gene Gene NNP cord-103204-gt6upfri 101 15 Data Data NNP cord-103204-gt6upfri 101 16 Sets set VBZ cord-103204-gt6upfri 101 17 HyPhy HyPhy NNP cord-103204-gt6upfri 101 18 : : : cord-103204-gt6upfri 102 1 hypothesis hypothesis NN cord-103204-gt6upfri 102 2 testing testing NN cord-103204-gt6upfri 102 3 using use VBG cord-103204-gt6upfri 102 4 phylogenies phylogeny NNS cord-103204-gt6upfri 102 5 Automated automate VBN cord-103204-gt6upfri 102 6 phylogenetic phylogenetic JJ cord-103204-gt6upfri 102 7 detection detection NN cord-103204-gt6upfri 102 8 of of IN cord-103204-gt6upfri 102 9 recombination recombination NN cord-103204-gt6upfri 102 10 using use VBG cord-103204-gt6upfri 102 11 a a DT cord-103204-gt6upfri 102 12 genetic genetic JJ cord-103204-gt6upfri 102 13 algorithm algorithm NN cord-103204-gt6upfri 102 14 GARD GARD NNP cord-103204-gt6upfri 102 15 : : : cord-103204-gt6upfri 102 16 a a DT cord-103204-gt6upfri 102 17 genetic genetic JJ cord-103204-gt6upfri 102 18 algorithm algorithm NN cord-103204-gt6upfri 102 19 for for IN cord-103204-gt6upfri 102 20 recombination recombination NN cord-103204-gt6upfri 102 21 detection detection NN cord-103204-gt6upfri 102 22 MODELTEST MODELTEST NNP cord-103204-gt6upfri 102 23 : : : cord-103204-gt6upfri 102 24 testing test VBG cord-103204-gt6upfri 102 25 the the DT cord-103204-gt6upfri 102 26 model model NN cord-103204-gt6upfri 102 27 of of IN cord-103204-gt6upfri 102 28 DNA dna NN cord-103204-gt6upfri 102 29 substitution substitution NN cord-103204-gt6upfri 102 30 Potential potential JJ cord-103204-gt6upfri 102 31 impact impact NN cord-103204-gt6upfri 102 32 of of IN cord-103204-gt6upfri 102 33 recombination recombination NN cord-103204-gt6upfri 102 34 on on IN cord-103204-gt6upfri 102 35 sitewise sitewise NN cord-103204-gt6upfri 102 36 approaches approach NNS cord-103204-gt6upfri 102 37 for for IN cord-103204-gt6upfri 102 38 detecting detect VBG cord-103204-gt6upfri 102 39 positive positive JJ cord-103204-gt6upfri 102 40 natural natural JJ cord-103204-gt6upfri 102 41 selection selection NN cord-103204-gt6upfri 102 42 RAxML RAxML VBZ cord-103204-gt6upfri 102 43 version version NN cord-103204-gt6upfri 102 44 8 8 CD cord-103204-gt6upfri 102 45 : : : cord-103204-gt6upfri 102 46 a a DT cord-103204-gt6upfri 102 47 tool tool NN cord-103204-gt6upfri 102 48 for for IN cord-103204-gt6upfri 102 49 phylogenetic phylogenetic JJ cord-103204-gt6upfri 102 50 analysis analysis NN cord-103204-gt6upfri 102 51 and and CC cord-103204-gt6upfri 102 52 postanalysis postanalysis NN cord-103204-gt6upfri 102 53 of of IN cord-103204-gt6upfri 102 54 large large JJ cord-103204-gt6upfri 102 55 phylogenies phylogeny NNS cord-103204-gt6upfri 102 56 Selecton Selecton NNP cord-103204-gt6upfri 102 57 2007 2007 CD cord-103204-gt6upfri 102 58 : : : cord-103204-gt6upfri 102 59 advanced advanced JJ cord-103204-gt6upfri 102 60 models model NNS cord-103204-gt6upfri 102 61 for for IN cord-103204-gt6upfri 102 62 detecting detect VBG cord-103204-gt6upfri 102 63 positive positive JJ cord-103204-gt6upfri 102 64 and and CC cord-103204-gt6upfri 102 65 purifying purify VBG cord-103204-gt6upfri 102 66 selection selection NN cord-103204-gt6upfri 102 67 using use VBG cord-103204-gt6upfri 102 68 a a DT cord-103204-gt6upfri 102 69 Bayesian bayesian JJ cord-103204-gt6upfri 102 70 inference inference NN cord-103204-gt6upfri 102 71 approach approach NN cord-103204-gt6upfri 102 72 PSP PSP NNP cord-103204-gt6upfri 102 73 : : : cord-103204-gt6upfri 102 74 rapid rapid JJ cord-103204-gt6upfri 102 75 identification identification NN cord-103204-gt6upfri 102 76 of of IN cord-103204-gt6upfri 102 77 orthologous orthologous JJ cord-103204-gt6upfri 102 78 coding code VBG cord-103204-gt6upfri 102 79 genes gene NNS cord-103204-gt6upfri 102 80 under under IN cord-103204-gt6upfri 102 81 positive positive JJ cord-103204-gt6upfri 102 82 selection selection NN cord-103204-gt6upfri 102 83 across across IN cord-103204-gt6upfri 102 84 multiple multiple JJ cord-103204-gt6upfri 102 85 closely closely RB cord-103204-gt6upfri 102 86 related related JJ cord-103204-gt6upfri 102 87 prokaryotic prokaryotic JJ cord-103204-gt6upfri 102 88 genomes genome NNS cord-103204-gt6upfri 102 89 Pervasive pervasive JJ cord-103204-gt6upfri 102 90 adaptive adaptive JJ cord-103204-gt6upfri 102 91 evolution evolution NN cord-103204-gt6upfri 102 92 in in IN cord-103204-gt6upfri 102 93 mammalian mammalian JJ cord-103204-gt6upfri 102 94 fertilization fertilization NN cord-103204-gt6upfri 102 95 proteins protein NNS cord-103204-gt6upfri 102 96 Detecting detect VBG cord-103204-gt6upfri 102 97 natural natural JJ cord-103204-gt6upfri 102 98 selection selection NN cord-103204-gt6upfri 102 99 in in IN cord-103204-gt6upfri 102 100 genomic genomic JJ cord-103204-gt6upfri 102 101 data datum NNS cord-103204-gt6upfri 102 102 VESPA vespa NN cord-103204-gt6upfri 102 103 : : : cord-103204-gt6upfri 102 104 very very RB cord-103204-gt6upfri 102 105 large large JJ cord-103204-gt6upfri 102 106 - - HYPH cord-103204-gt6upfri 102 107 scale scale NN cord-103204-gt6upfri 102 108 evolutionary evolutionary JJ cord-103204-gt6upfri 102 109 and and CC cord-103204-gt6upfri 102 110 selective selective JJ cord-103204-gt6upfri 102 111 pressure pressure NN cord-103204-gt6upfri 102 112 analyses analysis NNS cord-103204-gt6upfri 102 113 PAML PAML NNP cord-103204-gt6upfri 102 114 4 4 CD cord-103204-gt6upfri 102 115 : : : cord-103204-gt6upfri 103 1 phylogenetic phylogenetic JJ cord-103204-gt6upfri 103 2 analysis analysis NN cord-103204-gt6upfri 103 3 by by IN cord-103204-gt6upfri 103 4 maximum maximum JJ cord-103204-gt6upfri 103 5 likelihood likelihood NN cord-103204-gt6upfri 104 1 Bayes Bayes NNP cord-103204-gt6upfri 104 2 Empirical Empirical NNP cord-103204-gt6upfri 104 3 Bayes Bayes NNP cord-103204-gt6upfri 104 4 Inference Inference NNP cord-103204-gt6upfri 104 5 of of IN cord-103204-gt6upfri 104 6 Amino Amino NNP cord-103204-gt6upfri 104 7 Acid acid NN cord-103204-gt6upfri 104 8 Sites site NNS cord-103204-gt6upfri 104 9 Under under IN cord-103204-gt6upfri 104 10 Positive positive JJ cord-103204-gt6upfri 104 11 Selection selection NN