id sid tid token lemma pos cord-294218-v4gjabp3 1 1 key key NN cord-294218-v4gjabp3 1 2 : : : cord-294218-v4gjabp3 1 3 cord-294218-v4gjabp3 cord-294218-v4gjabp3 ADD cord-294218-v4gjabp3 2 1 authors author NNS cord-294218-v4gjabp3 2 2 : : : cord-294218-v4gjabp3 2 3 Dea Dea NNP cord-294218-v4gjabp3 2 4 , , , cord-294218-v4gjabp3 2 5 S. S. NNP cord-294218-v4gjabp3 2 6 ; ; : cord-294218-v4gjabp3 2 7 Garzon Garzon NNP cord-294218-v4gjabp3 2 8 , , , cord-294218-v4gjabp3 2 9 S. S. NNP cord-294218-v4gjabp3 2 10 ; ; : cord-294218-v4gjabp3 2 11 Tijssen Tijssen NNP cord-294218-v4gjabp3 2 12 , , , cord-294218-v4gjabp3 2 13 P. P. NNP cord-294218-v4gjabp3 2 14 title title NN cord-294218-v4gjabp3 2 15 : : : cord-294218-v4gjabp3 3 1 Intracellular intracellular JJ cord-294218-v4gjabp3 3 2 synthesis synthesis NN cord-294218-v4gjabp3 3 3 and and CC cord-294218-v4gjabp3 3 4 processing processing NN cord-294218-v4gjabp3 3 5 of of IN cord-294218-v4gjabp3 3 6 the the DT cord-294218-v4gjabp3 3 7 structural structural JJ cord-294218-v4gjabp3 3 8 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 3 9 of of IN cord-294218-v4gjabp3 3 10 turkey turkey NN cord-294218-v4gjabp3 3 11 enteric enteric JJ cord-294218-v4gjabp3 3 12 coronavirus coronavirus NN cord-294218-v4gjabp3 3 13 date date NN cord-294218-v4gjabp3 3 14 : : : cord-294218-v4gjabp3 3 15 1989 1989 CD cord-294218-v4gjabp3 3 16 journal journal NNP cord-294218-v4gjabp3 3 17 : : : cord-294218-v4gjabp3 4 1 Arch arch JJ cord-294218-v4gjabp3 4 2 Virol Virol NNP cord-294218-v4gjabp3 4 3 DOI doi NN cord-294218-v4gjabp3 4 4 : : : cord-294218-v4gjabp3 5 1 10.1007 10.1007 CD cord-294218-v4gjabp3 5 2 / / SYM cord-294218-v4gjabp3 5 3 bf01313956 bf01313956 NNP cord-294218-v4gjabp3 5 4 sha sha NNP cord-294218-v4gjabp3 5 5 : : : cord-294218-v4gjabp3 5 6 ff56926b9a45fe14f061e2df3f573214d73e4e6b ff56926b9a45fe14f061e2df3f573214d73e4e6b NNP cord-294218-v4gjabp3 5 7 doc_id doc_id CD cord-294218-v4gjabp3 5 8 : : : cord-294218-v4gjabp3 5 9 294218 294218 CD cord-294218-v4gjabp3 5 10 cord_uid cord_uid NNS cord-294218-v4gjabp3 5 11 : : : cord-294218-v4gjabp3 6 1 v4gjabp3 v4gjabp3 NNP cord-294218-v4gjabp3 6 2 Pulse pulse NN cord-294218-v4gjabp3 6 3 labeling labeling NN cord-294218-v4gjabp3 6 4 of of IN cord-294218-v4gjabp3 6 5 cells cell NNS cord-294218-v4gjabp3 6 6 with with IN cord-294218-v4gjabp3 6 7 [ [ -LRB- cord-294218-v4gjabp3 6 8 ( ( -LRB- cord-294218-v4gjabp3 6 9 35)S]methionine 35)s]methionine CD cord-294218-v4gjabp3 6 10 or or CC cord-294218-v4gjabp3 6 11 [ [ -LRB- cord-294218-v4gjabp3 6 12 ( ( -LRB- cord-294218-v4gjabp3 6 13 3)H]glucosamine 3)h]glucosamine CD cord-294218-v4gjabp3 6 14 at at IN cord-294218-v4gjabp3 6 15 different different JJ cord-294218-v4gjabp3 6 16 times time NNS cord-294218-v4gjabp3 6 17 after after IN cord-294218-v4gjabp3 6 18 infection infection NN cord-294218-v4gjabp3 6 19 , , , cord-294218-v4gjabp3 6 20 followed follow VBN cord-294218-v4gjabp3 6 21 by by IN cord-294218-v4gjabp3 6 22 SDS SDS NNP cord-294218-v4gjabp3 6 23 - - HYPH cord-294218-v4gjabp3 6 24 PAGE PAGE NNP cord-294218-v4gjabp3 6 25 and and CC cord-294218-v4gjabp3 6 26 Western western JJ cord-294218-v4gjabp3 6 27 immunoblotting immunoblotting NN cord-294218-v4gjabp3 6 28 analysis analysis NN cord-294218-v4gjabp3 6 29 using use VBG cord-294218-v4gjabp3 6 30 rabbit rabbit NNP cord-294218-v4gjabp3 6 31 anti anti NNP cord-294218-v4gjabp3 6 32 - - NNP cord-294218-v4gjabp3 6 33 TCV TCV NNP cord-294218-v4gjabp3 6 34 hyperimmune hyperimmune NNP cord-294218-v4gjabp3 6 35 serum serum NN cord-294218-v4gjabp3 6 36 , , , cord-294218-v4gjabp3 6 37 was be VBD cord-294218-v4gjabp3 6 38 used use VBN cord-294218-v4gjabp3 6 39 to to TO cord-294218-v4gjabp3 6 40 resolve resolve VB cord-294218-v4gjabp3 6 41 and and CC cord-294218-v4gjabp3 6 42 identify identify VB cord-294218-v4gjabp3 6 43 TCV TCV NNP cord-294218-v4gjabp3 6 44 - - HYPH cord-294218-v4gjabp3 6 45 induced induce VBN cord-294218-v4gjabp3 6 46 intracellular intracellular JJ cord-294218-v4gjabp3 6 47 proteins protein NNS cord-294218-v4gjabp3 6 48 . . . cord-294218-v4gjabp3 7 1 The the DT cord-294218-v4gjabp3 7 2 viral viral JJ cord-294218-v4gjabp3 7 3 structural structural JJ cord-294218-v4gjabp3 7 4 proteins protein NNS cord-294218-v4gjabp3 7 5 ( ( -LRB- cord-294218-v4gjabp3 7 6 gp200 gp200 UH cord-294218-v4gjabp3 7 7 , , , cord-294218-v4gjabp3 7 8 gp140 gp140 NNP cord-294218-v4gjabp3 7 9 / / SYM cord-294218-v4gjabp3 7 10 gp66 gp66 NNP cord-294218-v4gjabp3 7 11 , , , cord-294218-v4gjabp3 7 12 gp100 gp100 NNP cord-294218-v4gjabp3 7 13 / / SYM cord-294218-v4gjabp3 7 14 gp120 gp120 NNP cord-294218-v4gjabp3 7 15 , , , cord-294218-v4gjabp3 7 16 p52 p52 NN cord-294218-v4gjabp3 7 17 , , , cord-294218-v4gjabp3 7 18 and and CC cord-294218-v4gjabp3 7 19 gp24 gp24 NNP cord-294218-v4gjabp3 7 20 / / SYM cord-294218-v4gjabp3 7 21 p20 p20 NN cord-294218-v4gjabp3 7 22 ) ) -RRB- cord-294218-v4gjabp3 7 23 were be VBD cord-294218-v4gjabp3 7 24 detected detect VBN cord-294218-v4gjabp3 7 25 in in IN cord-294218-v4gjabp3 7 26 radiolabeled radiolabele VBN cord-294218-v4gjabp3 7 27 cell cell NN cord-294218-v4gjabp3 7 28 extracts extract NNS cord-294218-v4gjabp3 7 29 by by IN cord-294218-v4gjabp3 7 30 9 9 CD cord-294218-v4gjabp3 7 31 to to TO cord-294218-v4gjabp3 7 32 12 12 CD cord-294218-v4gjabp3 7 33 hours hour NNS cord-294218-v4gjabp3 7 34 post post NN cord-294218-v4gjabp3 7 35 - - NN cord-294218-v4gjabp3 7 36 infection infection NN cord-294218-v4gjabp3 7 37 , , , cord-294218-v4gjabp3 7 38 as as RB cord-294218-v4gjabp3 7 39 well well RB cord-294218-v4gjabp3 7 40 as as IN cord-294218-v4gjabp3 7 41 two two CD cord-294218-v4gjabp3 7 42 possible possible JJ cord-294218-v4gjabp3 7 43 non non JJ cord-294218-v4gjabp3 7 44 - - JJ cord-294218-v4gjabp3 7 45 structural structural JJ cord-294218-v4gjabp3 7 46 proteins protein NNS cord-294218-v4gjabp3 7 47 with with IN cord-294218-v4gjabp3 7 48 apparent apparent JJ cord-294218-v4gjabp3 7 49 mol.wts mol.wt NNS cord-294218-v4gjabp3 7 50 . . . cord-294218-v4gjabp3 8 1 of of IN cord-294218-v4gjabp3 8 2 36,000 36,000 CD cord-294218-v4gjabp3 8 3 and and CC cord-294218-v4gjabp3 8 4 32,000 32,000 CD cord-294218-v4gjabp3 8 5 . . . cord-294218-v4gjabp3 9 1 The the DT cord-294218-v4gjabp3 9 2 predominant predominant JJ cord-294218-v4gjabp3 9 3 52,000 52,000 CD cord-294218-v4gjabp3 9 4 nucleocapsid nucleocapsid NN cord-294218-v4gjabp3 9 5 protein protein NN cord-294218-v4gjabp3 9 6 could could MD cord-294218-v4gjabp3 9 7 be be VB cord-294218-v4gjabp3 9 8 detected detect VBN cord-294218-v4gjabp3 9 9 in in IN cord-294218-v4gjabp3 9 10 cell cell NN cord-294218-v4gjabp3 9 11 lysates lysate NNS cord-294218-v4gjabp3 9 12 as as RB cord-294218-v4gjabp3 9 13 soon soon RB cord-294218-v4gjabp3 9 14 as as IN cord-294218-v4gjabp3 9 15 6 6 CD cord-294218-v4gjabp3 9 16 to to TO cord-294218-v4gjabp3 9 17 8 8 CD cord-294218-v4gjabp3 9 18 hours hour NNS cord-294218-v4gjabp3 9 19 after after IN cord-294218-v4gjabp3 9 20 infection infection NN cord-294218-v4gjabp3 9 21 ; ; : cord-294218-v4gjabp3 9 22 it -PRON- PRP cord-294218-v4gjabp3 9 23 was be VBD cord-294218-v4gjabp3 9 24 initially initially RB cord-294218-v4gjabp3 9 25 resolved resolve VBN cord-294218-v4gjabp3 9 26 as as IN cord-294218-v4gjabp3 9 27 a a DT cord-294218-v4gjabp3 9 28 complex complex NN cord-294218-v4gjabp3 9 29 of of IN cord-294218-v4gjabp3 9 30 3 3 CD cord-294218-v4gjabp3 9 31 closely closely RB cord-294218-v4gjabp3 9 32 migrating migrate VBG cord-294218-v4gjabp3 9 33 species specie NNS cord-294218-v4gjabp3 9 34 with with IN cord-294218-v4gjabp3 9 35 mol.wts mol.wt NNS cord-294218-v4gjabp3 9 36 . . . cord-294218-v4gjabp3 10 1 ranging range VBG cord-294218-v4gjabp3 10 2 from from IN cord-294218-v4gjabp3 10 3 46,000 46,000 CD cord-294218-v4gjabp3 10 4 to to TO cord-294218-v4gjabp3 10 5 52,000 52,000 CD cord-294218-v4gjabp3 10 6 . . . cord-294218-v4gjabp3 11 1 Pulse pulse NN cord-294218-v4gjabp3 11 2 - - HYPH cord-294218-v4gjabp3 11 3 chase chase NN cord-294218-v4gjabp3 11 4 and and CC cord-294218-v4gjabp3 11 5 immunoprecipitation immunoprecipitation NN cord-294218-v4gjabp3 11 6 experiments experiment NNS cord-294218-v4gjabp3 11 7 indicated indicate VBD cord-294218-v4gjabp3 11 8 that that IN cord-294218-v4gjabp3 11 9 gp200 gp200 NN cord-294218-v4gjabp3 11 10 arose arise VBD cord-294218-v4gjabp3 11 11 from from IN cord-294218-v4gjabp3 11 12 a a DT cord-294218-v4gjabp3 11 13 putative putative JJ cord-294218-v4gjabp3 11 14 precursor precursor NN cord-294218-v4gjabp3 11 15 with with IN cord-294218-v4gjabp3 11 16 mol.wt mol.wt NNP cord-294218-v4gjabp3 11 17 . . . cord-294218-v4gjabp3 12 1 of of IN cord-294218-v4gjabp3 12 2 150,000 150,000 CD cord-294218-v4gjabp3 12 3 to to TO cord-294218-v4gjabp3 12 4 170,000 170,000 CD cord-294218-v4gjabp3 12 5 , , , cord-294218-v4gjabp3 12 6 that that WDT cord-294218-v4gjabp3 12 7 underwent undergo VBD cord-294218-v4gjabp3 12 8 glycosylation glycosylation NN cord-294218-v4gjabp3 12 9 . . . cord-294218-v4gjabp3 13 1 Proteolytic proteolytic JJ cord-294218-v4gjabp3 13 2 cleavage cleavage NN cord-294218-v4gjabp3 13 3 of of IN cord-294218-v4gjabp3 13 4 gp200 gp200 NN cord-294218-v4gjabp3 13 5 , , , cord-294218-v4gjabp3 13 6 in in IN cord-294218-v4gjabp3 13 7 turn turn NN cord-294218-v4gjabp3 13 8 , , , cord-294218-v4gjabp3 13 9 probably probably RB cord-294218-v4gjabp3 13 10 yielded yield VBD cord-294218-v4gjabp3 13 11 the the DT cord-294218-v4gjabp3 13 12 gp100 gp100 NN cord-294218-v4gjabp3 13 13 and and CC cord-294218-v4gjabp3 13 14 gp120 gp120 NNP cord-294218-v4gjabp3 13 15 species specie NNS cord-294218-v4gjabp3 13 16 . . . cord-294218-v4gjabp3 14 1 The the DT cord-294218-v4gjabp3 14 2 unique unique JJ cord-294218-v4gjabp3 14 3 TCV TCV NNP cord-294218-v4gjabp3 14 4 hemagglutinin hemagglutinin NN cord-294218-v4gjabp3 14 5 protein protein NN cord-294218-v4gjabp3 14 6 originated originate VBD cord-294218-v4gjabp3 14 7 from from IN cord-294218-v4gjabp3 14 8 a a DT cord-294218-v4gjabp3 14 9 primary primary JJ cord-294218-v4gjabp3 14 10 precursor precursor NN cord-294218-v4gjabp3 14 11 with with IN cord-294218-v4gjabp3 14 12 mol.wt mol.wt NNP cord-294218-v4gjabp3 14 13 . . . cord-294218-v4gjabp3 15 1 of of IN cord-294218-v4gjabp3 15 2 60,000 60,000 CD cord-294218-v4gjabp3 15 3 , , , cord-294218-v4gjabp3 15 4 which which WDT cord-294218-v4gjabp3 15 5 underwent undergo VBD cord-294218-v4gjabp3 15 6 rapid rapid JJ cord-294218-v4gjabp3 15 7 dimerization dimerization NN cord-294218-v4gjabp3 15 8 by by IN cord-294218-v4gjabp3 15 9 disulfide disulfide JJ cord-294218-v4gjabp3 15 10 bond bond NN cord-294218-v4gjabp3 15 11 formation formation NN cord-294218-v4gjabp3 15 12 and and CC cord-294218-v4gjabp3 15 13 glycosylation glycosylation NN cord-294218-v4gjabp3 15 14 to to TO cord-294218-v4gjabp3 15 15 yield yield VB cord-294218-v4gjabp3 15 16 gp140 gp140 NNP cord-294218-v4gjabp3 15 17 . . . cord-294218-v4gjabp3 16 1 The the DT cord-294218-v4gjabp3 16 2 peplomeric peplomeric JJ cord-294218-v4gjabp3 16 3 and and CC cord-294218-v4gjabp3 16 4 matrix matrix NN cord-294218-v4gjabp3 16 5 proteins protein NNS cord-294218-v4gjabp3 16 6 were be VBD cord-294218-v4gjabp3 16 7 both both DT cord-294218-v4gjabp3 16 8 shown show VBN cord-294218-v4gjabp3 16 9 to to TO cord-294218-v4gjabp3 16 10 be be VB cord-294218-v4gjabp3 16 11 N n NN cord-294218-v4gjabp3 16 12 - - HYPH cord-294218-v4gjabp3 16 13 glycosylated glycosylate VBN cord-294218-v4gjabp3 16 14 , , , cord-294218-v4gjabp3 16 15 as as IN cord-294218-v4gjabp3 16 16 indicated indicate VBN cord-294218-v4gjabp3 16 17 by by IN cord-294218-v4gjabp3 16 18 their -PRON- PRP$ cord-294218-v4gjabp3 16 19 sensitivity sensitivity NN cord-294218-v4gjabp3 16 20 to to IN cord-294218-v4gjabp3 16 21 tunicamycin tunicamycin NNS cord-294218-v4gjabp3 16 22 ( ( -LRB- cord-294218-v4gjabp3 16 23 TM TM NNP cord-294218-v4gjabp3 16 24 ) ) -RRB- cord-294218-v4gjabp3 16 25 and and CC cord-294218-v4gjabp3 16 26 their -PRON- PRP$ cord-294218-v4gjabp3 16 27 resistance resistance NN cord-294218-v4gjabp3 16 28 to to IN cord-294218-v4gjabp3 16 29 sodium sodium NN cord-294218-v4gjabp3 16 30 monensin monensin NNP cord-294218-v4gjabp3 16 31 ( ( -LRB- cord-294218-v4gjabp3 16 32 SM SM NNP cord-294218-v4gjabp3 16 33 ) ) -RRB- cord-294218-v4gjabp3 16 34 . . . cord-294218-v4gjabp3 17 1 In in IN cord-294218-v4gjabp3 17 2 the the DT cord-294218-v4gjabp3 17 3 presence presence NN cord-294218-v4gjabp3 17 4 of of IN cord-294218-v4gjabp3 17 5 TM TM NNP cord-294218-v4gjabp3 17 6 , , , cord-294218-v4gjabp3 17 7 proteins protein NNS cord-294218-v4gjabp3 17 8 with with IN cord-294218-v4gjabp3 17 9 mol.wts mol.wt NNS cord-294218-v4gjabp3 17 10 . . . cord-294218-v4gjabp3 18 1 of of IN cord-294218-v4gjabp3 18 2 90,000 90,000 CD cord-294218-v4gjabp3 18 3 , , , cord-294218-v4gjabp3 18 4 120–130,000 120–130,000 CD cord-294218-v4gjabp3 18 5 , , , cord-294218-v4gjabp3 18 6 and and CC cord-294218-v4gjabp3 18 7 150,000 150,000 CD cord-294218-v4gjabp3 18 8 accumulated accumulate VBN cord-294218-v4gjabp3 18 9 in in IN cord-294218-v4gjabp3 18 10 TCV TCV NNP cord-294218-v4gjabp3 18 11 - - HYPH cord-294218-v4gjabp3 18 12 infected infect VBN cord-294218-v4gjabp3 18 13 cells cell NNS cord-294218-v4gjabp3 18 14 rather rather RB cord-294218-v4gjabp3 18 15 than than IN cord-294218-v4gjabp3 18 16 peplomeric peplomeric JJ cord-294218-v4gjabp3 18 17 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 18 18 , , , cord-294218-v4gjabp3 18 19 and and CC cord-294218-v4gjabp3 18 20 the the DT cord-294218-v4gjabp3 18 21 matrix matrix NN cord-294218-v4gjabp3 18 22 protein protein NN cord-294218-v4gjabp3 18 23 E1 E1 NNP cord-294218-v4gjabp3 18 24 was be VBD cord-294218-v4gjabp3 18 25 only only RB cord-294218-v4gjabp3 18 26 detected detect VBN cord-294218-v4gjabp3 18 27 in in IN cord-294218-v4gjabp3 18 28 its -PRON- PRP$ cord-294218-v4gjabp3 18 29 unglycosylated unglycosylated JJ cord-294218-v4gjabp3 18 30 form form NN cord-294218-v4gjabp3 18 31 . . . cord-294218-v4gjabp3 19 1 The the DT cord-294218-v4gjabp3 19 2 addition addition NN cord-294218-v4gjabp3 19 3 of of IN cord-294218-v4gjabp3 19 4 TM TM NNP cord-294218-v4gjabp3 19 5 to to IN cord-294218-v4gjabp3 19 6 the the DT cord-294218-v4gjabp3 19 7 culture culture NN cord-294218-v4gjabp3 19 8 medium medium NN cord-294218-v4gjabp3 19 9 interfered interfere VBD cord-294218-v4gjabp3 19 10 with with IN cord-294218-v4gjabp3 19 11 the the DT cord-294218-v4gjabp3 19 12 maturation maturation NN cord-294218-v4gjabp3 19 13 of of IN cord-294218-v4gjabp3 19 14 progeny progeny JJ cord-294218-v4gjabp3 19 15 viral viral JJ cord-294218-v4gjabp3 19 16 particles particle NNS cord-294218-v4gjabp3 19 17 , , , cord-294218-v4gjabp3 19 18 as as IN cord-294218-v4gjabp3 19 19 suggested suggest VBN cord-294218-v4gjabp3 19 20 by by IN cord-294218-v4gjabp3 19 21 the the DT cord-294218-v4gjabp3 19 22 absence absence NN cord-294218-v4gjabp3 19 23 of of IN cord-294218-v4gjabp3 19 24 peplomers peplomer NNS cord-294218-v4gjabp3 19 25 at at IN cord-294218-v4gjabp3 19 26 the the DT cord-294218-v4gjabp3 19 27 surface surface NN cord-294218-v4gjabp3 19 28 of of IN cord-294218-v4gjabp3 19 29 the the DT cord-294218-v4gjabp3 19 30 intravacuolar intravacuolar JJ cord-294218-v4gjabp3 19 31 and and CC cord-294218-v4gjabp3 19 32 extracellular extracellular JJ cord-294218-v4gjabp3 19 33 virions virion NNS cord-294218-v4gjabp3 19 34 , , , cord-294218-v4gjabp3 19 35 and and CC cord-294218-v4gjabp3 19 36 the the DT cord-294218-v4gjabp3 19 37 accumulation accumulation NN cord-294218-v4gjabp3 19 38 of of IN cord-294218-v4gjabp3 19 39 amorphous amorphous JJ cord-294218-v4gjabp3 19 40 material material NN cord-294218-v4gjabp3 19 41 not not RB cord-294218-v4gjabp3 19 42 found find VBN cord-294218-v4gjabp3 19 43 in in IN cord-294218-v4gjabp3 19 44 the the DT cord-294218-v4gjabp3 19 45 absence absence NN cord-294218-v4gjabp3 19 46 of of IN cord-294218-v4gjabp3 19 47 the the DT cord-294218-v4gjabp3 19 48 glycosylation glycosylation NN cord-294218-v4gjabp3 19 49 inhibitor inhibitor NN cord-294218-v4gjabp3 19 50 . . . cord-294218-v4gjabp3 20 1 High high JJ cord-294218-v4gjabp3 20 2 yields yield NNS cord-294218-v4gjabp3 20 3 of of IN cord-294218-v4gjabp3 20 4 virus virus NN cord-294218-v4gjabp3 20 5 replication replication NN cord-294218-v4gjabp3 20 6 were be VBD cord-294218-v4gjabp3 20 7 obtained obtain VBN cord-294218-v4gjabp3 20 8 , , , cord-294218-v4gjabp3 20 9 in in IN cord-294218-v4gjabp3 20 10 the the DT cord-294218-v4gjabp3 20 11 presence presence NN cord-294218-v4gjabp3 20 12 of of IN cord-294218-v4gjabp3 20 13 SM SM NNP cord-294218-v4gjabp3 20 14 , , , cord-294218-v4gjabp3 20 15 even even RB cord-294218-v4gjabp3 20 16 at at IN cord-294218-v4gjabp3 20 17 concentrations concentration NNS cord-294218-v4gjabp3 20 18 which which WDT cord-294218-v4gjabp3 20 19 greatly greatly RB cord-294218-v4gjabp3 20 20 affected affect VBD cord-294218-v4gjabp3 20 21 the the DT cord-294218-v4gjabp3 20 22 cellular cellular JJ cord-294218-v4gjabp3 20 23 functions function NNS cord-294218-v4gjabp3 20 24 . . . cord-294218-v4gjabp3 21 1 The the DT cord-294218-v4gjabp3 21 2 coronavirus coronavirus NN cord-294218-v4gjabp3 21 3 virion virion NN cord-294218-v4gjabp3 21 4 possesses possess VBZ cord-294218-v4gjabp3 21 5 two two CD cord-294218-v4gjabp3 21 6 or or CC cord-294218-v4gjabp3 21 7 three three CD cord-294218-v4gjabp3 21 8 major major JJ cord-294218-v4gjabp3 21 9 envelope envelope NN cord-294218-v4gjabp3 21 10 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 21 11 [ [ -LRB- cord-294218-v4gjabp3 21 12 40 40 CD cord-294218-v4gjabp3 21 13 ] ] -RRB- cord-294218-v4gjabp3 21 14 . . . cord-294218-v4gjabp3 22 1 The the DT cord-294218-v4gjabp3 22 2 latter latter JJ cord-294218-v4gjabp3 22 3 are be VBP cord-294218-v4gjabp3 22 4 synthesized synthesize VBN cord-294218-v4gjabp3 22 5 from from IN cord-294218-v4gjabp3 22 6 different different JJ cord-294218-v4gjabp3 22 7 virus virus NN cord-294218-v4gjabp3 22 8 - - HYPH cord-294218-v4gjabp3 22 9 specific specific JJ cord-294218-v4gjabp3 22 10 subgenomic subgenomic JJ cord-294218-v4gjabp3 22 11 RNAs rna NNS cord-294218-v4gjabp3 22 12 which which WDT cord-294218-v4gjabp3 22 13 are be VBP cord-294218-v4gjabp3 22 14 translated translate VBN cord-294218-v4gjabp3 22 15 at at IN cord-294218-v4gjabp3 22 16 the the DT cord-294218-v4gjabp3 22 17 level level NN cord-294218-v4gjabp3 22 18 Of of IN cord-294218-v4gjabp3 22 19 membrane membrane NN cord-294218-v4gjabp3 22 20 - - HYPH cord-294218-v4gjabp3 22 21 bound bind VBN cord-294218-v4gjabp3 22 22 ribosomes ribosome NNS cord-294218-v4gjabp3 22 23 [ [ -LRB- cord-294218-v4gjabp3 22 24 34 34 CD cord-294218-v4gjabp3 22 25 , , , cord-294218-v4gjabp3 22 26 35 35 CD cord-294218-v4gjabp3 22 27 ] ] -RRB- cord-294218-v4gjabp3 22 28 , , , cord-294218-v4gjabp3 22 29 and and CC cord-294218-v4gjabp3 22 30 then then RB cord-294218-v4gjabp3 22 31 undergo undergo VB cord-294218-v4gjabp3 22 32 post post JJ cord-294218-v4gjabp3 22 33 - - JJ cord-294218-v4gjabp3 22 34 translational translational JJ cord-294218-v4gjabp3 22 35 processing processing NN cord-294218-v4gjabp3 22 36 at at IN cord-294218-v4gjabp3 22 37 the the DT cord-294218-v4gjabp3 22 38 level level NN cord-294218-v4gjabp3 22 39 of of IN cord-294218-v4gjabp3 22 40 rough rough JJ cord-294218-v4gjabp3 22 41 endoplasmic endoplasmic NN cord-294218-v4gjabp3 22 42 reticulum reticulum NN cord-294218-v4gjabp3 22 43 or or CC cord-294218-v4gjabp3 22 44 Golgi Golgi NNP cord-294218-v4gjabp3 22 45 apparatus apparatus NN cord-294218-v4gjabp3 22 46 [ [ -LRB- cord-294218-v4gjabp3 22 47 40 40 CD cord-294218-v4gjabp3 22 48 , , , cord-294218-v4gjabp3 22 49 42 42 CD cord-294218-v4gjabp3 22 50 ] ] -RRB- cord-294218-v4gjabp3 22 51 . . . cord-294218-v4gjabp3 23 1 The the DT cord-294218-v4gjabp3 23 2 peplomeric peplomeric JJ cord-294218-v4gjabp3 23 3 ( ( -LRB- cord-294218-v4gjabp3 23 4 E2 E2 NNP cord-294218-v4gjabp3 23 5 ) ) -RRB- cord-294218-v4gjabp3 23 6 protein protein NN cord-294218-v4gjabp3 23 7 precursors precursor NNS cord-294218-v4gjabp3 23 8 of of IN cord-294218-v4gjabp3 23 9 mouse mouse NN cord-294218-v4gjabp3 23 10 hepatitis hepatitis NNP cord-294218-v4gjabp3 23 11 ( ( -LRB- cord-294218-v4gjabp3 23 12 MHV MHV NNP cord-294218-v4gjabp3 23 13 ) ) -RRB- cord-294218-v4gjabp3 23 14 and and CC cord-294218-v4gjabp3 23 15 avian avian JJ cord-294218-v4gjabp3 23 16 infectious infectious JJ cord-294218-v4gjabp3 23 17 bronchitis bronchitis NN cord-294218-v4gjabp3 23 18 ( ( -LRB- cord-294218-v4gjabp3 23 19 IBV IBV NNP cord-294218-v4gjabp3 23 20 ) ) -RRB- cord-294218-v4gjabp3 24 1 viruses virus NNS cord-294218-v4gjabp3 24 2 are be VBP cord-294218-v4gjabp3 24 3 cotranslationally cotranslationally RB cord-294218-v4gjabp3 24 4 N n CD cord-294218-v4gjabp3 24 5 - - HYPH cord-294218-v4gjabp3 24 6 glycosylated glycosylate VBN cord-294218-v4gjabp3 24 7 and and CC cord-294218-v4gjabp3 24 8 have have VBP cord-294218-v4gjabp3 24 9 then then RB cord-294218-v4gjabp3 24 10 an an DT cord-294218-v4gjabp3 24 11 apparent apparent JJ cord-294218-v4gjabp3 24 12 mol.wt mol.wt NN cord-294218-v4gjabp3 24 13 , , , cord-294218-v4gjabp3 24 14 of of IN cord-294218-v4gjabp3 24 15 150,000 150,000 CD cord-294218-v4gjabp3 24 16 [ [ -LRB- cord-294218-v4gjabp3 24 17 27 27 CD cord-294218-v4gjabp3 24 18 , , , cord-294218-v4gjabp3 24 19 32 32 CD cord-294218-v4gjabp3 24 20 , , , cord-294218-v4gjabp3 24 21 36 36 CD cord-294218-v4gjabp3 24 22 ] ] -RRB- cord-294218-v4gjabp3 24 23 . . . cord-294218-v4gjabp3 25 1 The the DT cord-294218-v4gjabp3 25 2 polypeptides polypeptide NNS cord-294218-v4gjabp3 25 3 synthesized synthesize VBN cord-294218-v4gjabp3 25 4 in in IN cord-294218-v4gjabp3 25 5 vitro vitro FW cord-294218-v4gjabp3 25 6 or or CC cord-294218-v4gjabp3 25 7 in in IN cord-294218-v4gjabp3 25 8 tunicamycin tunicamycin NNS cord-294218-v4gjabp3 25 9 - - HYPH cord-294218-v4gjabp3 25 10 treated treat VBN cord-294218-v4gjabp3 25 11 cells cell NNS cord-294218-v4gjabp3 25 12 have have VBP cord-294218-v4gjabp3 25 13 a a DT cord-294218-v4gjabp3 25 14 mol.wt mol.wt NNP cord-294218-v4gjabp3 25 15 , , , cord-294218-v4gjabp3 25 16 of of IN cord-294218-v4gjabp3 25 17 approximately approximately RB cord-294218-v4gjabp3 25 18 120,000 120,000 CD cord-294218-v4gjabp3 25 19 [ [ -LRB- cord-294218-v4gjabp3 25 20 3 3 CD cord-294218-v4gjabp3 25 21 , , , cord-294218-v4gjabp3 25 22 28 28 CD cord-294218-v4gjabp3 25 23 , , , cord-294218-v4gjabp3 25 24 33 33 CD cord-294218-v4gjabp3 25 25 ] ] -RRB- cord-294218-v4gjabp3 25 26 . . . cord-294218-v4gjabp3 26 1 This this DT cord-294218-v4gjabp3 26 2 agrees agree VBZ cord-294218-v4gjabp3 26 3 with with IN cord-294218-v4gjabp3 26 4 the the DT cord-294218-v4gjabp3 26 5 mol.wts mol.wt NNS cord-294218-v4gjabp3 26 6 , , , cord-294218-v4gjabp3 26 7 of of IN cord-294218-v4gjabp3 26 8 the the DT cord-294218-v4gjabp3 26 9 polypeptide polypeptide NN cord-294218-v4gjabp3 26 10 moieties moiety NNS cord-294218-v4gjabp3 26 11 predicted predict VBN cord-294218-v4gjabp3 26 12 from from IN cord-294218-v4gjabp3 26 13 nucleotide nucleotide JJ cord-294218-v4gjabp3 26 14 sequences sequence NNS cord-294218-v4gjabp3 26 15 of of IN cord-294218-v4gjabp3 26 16 their -PRON- PRP$ cord-294218-v4gjabp3 26 17 E2 E2 NNP cord-294218-v4gjabp3 26 18 genes gene NNS cord-294218-v4gjabp3 26 19 [ [ -LRB- cord-294218-v4gjabp3 26 20 1 1 CD cord-294218-v4gjabp3 26 21 , , , cord-294218-v4gjabp3 26 22 20 20 CD cord-294218-v4gjabp3 26 23 , , , cord-294218-v4gjabp3 26 24 31 31 CD cord-294218-v4gjabp3 26 25 ] ] -RRB- cord-294218-v4gjabp3 26 26 . . . cord-294218-v4gjabp3 27 1 A a DT cord-294218-v4gjabp3 27 2 glycoprotein glycoprotein NN cord-294218-v4gjabp3 27 3 with with IN cord-294218-v4gjabp3 27 4 a a DT cord-294218-v4gjabp3 27 5 mol.wt mol.wt NNP cord-294218-v4gjabp3 27 6 , , , cord-294218-v4gjabp3 27 7 of of IN cord-294218-v4gjabp3 27 8 approximately approximately RB cord-294218-v4gjabp3 27 9 170,000 170,000 CD cord-294218-v4gjabp3 27 10 has have VBZ cord-294218-v4gjabp3 27 11 been be VBN cord-294218-v4gjabp3 27 12 identified identify VBN cord-294218-v4gjabp3 27 13 as as IN cord-294218-v4gjabp3 27 14 the the DT cord-294218-v4gjabp3 27 15 intracellular intracellular JJ cord-294218-v4gjabp3 27 16 precursor precursor NN cord-294218-v4gjabp3 27 17 of of IN cord-294218-v4gjabp3 27 18 the the DT cord-294218-v4gjabp3 27 19 E2 E2 NNP cord-294218-v4gjabp3 27 20 protein protein NN cord-294218-v4gjabp3 27 21 of of IN cord-294218-v4gjabp3 27 22 bovine bovine JJ cord-294218-v4gjabp3 27 23 enteric enteric JJ cord-294218-v4gjabp3 27 24 coronavirus coronavirus NN cord-294218-v4gjabp3 27 25 ( ( -LRB- cord-294218-v4gjabp3 27 26 BCV BCV NNP cord-294218-v4gjabp3 27 27 ) ) -RRB- cord-294218-v4gjabp3 27 28 , , , cord-294218-v4gjabp3 27 29 and and CC cord-294218-v4gjabp3 27 30 hemagglutinating hemagglutinate VBG cord-294218-v4gjabp3 27 31 mammalian mammalian JJ cord-294218-v4gjabp3 27 32 coronavirus coronavirus NN cord-294218-v4gjabp3 27 33 [ [ -LRB- cord-294218-v4gjabp3 27 34 9 9 CD cord-294218-v4gjabp3 27 35 , , , cord-294218-v4gjabp3 27 36 10 10 CD cord-294218-v4gjabp3 27 37 ] ] -RRB- cord-294218-v4gjabp3 27 38 . . . cord-294218-v4gjabp3 28 1 Unglycosylated Unglycosylated NNP cord-294218-v4gjabp3 28 2 precursors precursor NNS cord-294218-v4gjabp3 28 3 have have VBP cord-294218-v4gjabp3 28 4 not not RB cord-294218-v4gjabp3 28 5 been be VBN cord-294218-v4gjabp3 28 6 yet yet RB cord-294218-v4gjabp3 28 7 identified identify VBN cord-294218-v4gjabp3 28 8 for for IN cord-294218-v4gjabp3 28 9 BCV BCV NNP cord-294218-v4gjabp3 28 10 , , , cord-294218-v4gjabp3 28 11 but but CC cord-294218-v4gjabp3 28 12 concomitant concomitant JJ cord-294218-v4gjabp3 28 13 with with IN cord-294218-v4gjabp3 28 14 the the DT cord-294218-v4gjabp3 28 15 loss loss NN cord-294218-v4gjabp3 28 16 of of IN cord-294218-v4gjabp3 28 17 its -PRON- PRP$ cord-294218-v4gjabp3 28 18 surface surface NN cord-294218-v4gjabp3 28 19 projections projection NNS cord-294218-v4gjabp3 28 20 , , , cord-294218-v4gjabp3 28 21 the the DT cord-294218-v4gjabp3 28 22 virus virus NN cord-294218-v4gjabp3 28 23 is be VBZ cord-294218-v4gjabp3 28 24 neither neither CC cord-294218-v4gjabp3 28 25 infectious infectious JJ cord-294218-v4gjabp3 28 26 nor nor CC cord-294218-v4gjabp3 28 27 hemagglutinating hemagglutinate VBG cord-294218-v4gjabp3 28 28 , , , cord-294218-v4gjabp3 28 29 after after IN cord-294218-v4gjabp3 28 30 cultivation cultivation NN cord-294218-v4gjabp3 28 31 in in IN cord-294218-v4gjabp3 28 32 the the DT cord-294218-v4gjabp3 28 33 presence presence NN cord-294218-v4gjabp3 28 34 of of IN cord-294218-v4gjabp3 28 35 TM TM NNP cord-294218-v4gjabp3 28 36 [ [ -LRB- cord-294218-v4gjabp3 28 37 10 10 CD cord-294218-v4gjabp3 28 38 ] ] -RRB- cord-294218-v4gjabp3 28 39 . . . cord-294218-v4gjabp3 29 1 Following follow VBG cord-294218-v4gjabp3 29 2 further further JJ cord-294218-v4gjabp3 29 3 glycosylation glycosylation NN cord-294218-v4gjabp3 29 4 , , , cord-294218-v4gjabp3 29 5 the the DT cord-294218-v4gjabp3 29 6 peplomeric peplomeric JJ cord-294218-v4gjabp3 29 7 protein protein NN cord-294218-v4gjabp3 29 8 of of IN cord-294218-v4gjabp3 29 9 these these DT cord-294218-v4gjabp3 29 10 coronaviruses coronaviruse NNS cord-294218-v4gjabp3 29 11 undergoes undergo VBZ cord-294218-v4gjabp3 29 12 proteolytic proteolytic JJ cord-294218-v4gjabp3 29 13 cleavage cleavage NN cord-294218-v4gjabp3 29 14 to to TO cord-294218-v4gjabp3 29 15 yield yield VB cord-294218-v4gjabp3 29 16 two two CD cord-294218-v4gjabp3 29 17 subunits subunit NNS cord-294218-v4gjabp3 29 18 with with IN cord-294218-v4gjabp3 29 19 mol.wts mol.wt NNS cord-294218-v4gjabp3 29 20 , , , cord-294218-v4gjabp3 29 21 of of IN cord-294218-v4gjabp3 29 22 85 85 CD cord-294218-v4gjabp3 29 23 - - SYM cord-294218-v4gjabp3 29 24 100,000 100,000 CD cord-294218-v4gjabp3 29 25 [ [ -LRB- cord-294218-v4gjabp3 29 26 9 9 CD cord-294218-v4gjabp3 29 27 , , , cord-294218-v4gjabp3 29 28 20 20 CD cord-294218-v4gjabp3 29 29 , , , cord-294218-v4gjabp3 29 30 41 41 CD cord-294218-v4gjabp3 29 31 ] ] -RRB- cord-294218-v4gjabp3 29 32 . . . cord-294218-v4gjabp3 30 1 This this DT cord-294218-v4gjabp3 30 2 proteolytic proteolytic JJ cord-294218-v4gjabp3 30 3 cleavage cleavage NN cord-294218-v4gjabp3 30 4 is be VBZ cord-294218-v4gjabp3 30 5 a a DT cord-294218-v4gjabp3 30 6 host host NN cord-294218-v4gjabp3 30 7 - - HYPH cord-294218-v4gjabp3 30 8 cell cell NN cord-294218-v4gjabp3 30 9 dependent dependent JJ cord-294218-v4gjabp3 30 10 event event NN cord-294218-v4gjabp3 30 11 and and CC cord-294218-v4gjabp3 30 12 is be VBZ cord-294218-v4gjabp3 30 13 required require VBN cord-294218-v4gjabp3 30 14 for for IN cord-294218-v4gjabp3 30 15 activation activation NN cord-294218-v4gjabp3 30 16 of of IN cord-294218-v4gjabp3 30 17 the the DT cord-294218-v4gjabp3 30 18 cell cell NN cord-294218-v4gjabp3 30 19 - - HYPH cord-294218-v4gjabp3 30 20 fusing fuse VBG cord-294218-v4gjabp3 30 21 activity activity NN cord-294218-v4gjabp3 30 22 , , , cord-294218-v4gjabp3 30 23 and and CC cord-294218-v4gjabp3 30 24 therefore therefore RB cord-294218-v4gjabp3 30 25 appears appear VBZ cord-294218-v4gjabp3 30 26 to to TO cord-294218-v4gjabp3 30 27 be be VB cord-294218-v4gjabp3 30 28 an an DT cord-294218-v4gjabp3 30 29 important important JJ cord-294218-v4gjabp3 30 30 determinant determinant NN cord-294218-v4gjabp3 30 31 of of IN cord-294218-v4gjabp3 30 32 viral viral JJ cord-294218-v4gjabp3 30 33 pathogenesis pathogenesis NN cord-294218-v4gjabp3 30 34 [ [ -LRB- cord-294218-v4gjabp3 30 35 12 12 CD cord-294218-v4gjabp3 30 36 ] ] -RRB- cord-294218-v4gjabp3 30 37 . . . cord-294218-v4gjabp3 31 1 The the DT cord-294218-v4gjabp3 31 2 precursor precursor NN cord-294218-v4gjabp3 31 3 proteins protein VBZ cord-294218-v4gjabp3 31 4 to to IN cord-294218-v4gjabp3 31 5 the the DT cord-294218-v4gjabp3 31 6 BCV BCV NNP cord-294218-v4gjabp3 31 7 hemagglutinating hemagglutinate VBG cord-294218-v4gjabp3 31 8 protein protein NN cord-294218-v4gjabp3 31 9 ( ( -LRB- cord-294218-v4gjabp3 31 10 gp gp NNP cord-294218-v4gjabp3 31 11 124 124 CD cord-294218-v4gjabp3 31 12 / / SYM cord-294218-v4gjabp3 31 13 gp62 gp62 NNP cord-294218-v4gjabp3 31 14 ) ) -RRB- cord-294218-v4gjabp3 31 15 are be VBP cord-294218-v4gjabp3 31 16 gp59 gp59 JJ cord-294218-v4gjabp3 31 17 ( ( -LRB- cord-294218-v4gjabp3 31 18 monomer monomer NN cord-294218-v4gjabp3 31 19 ) ) -RRB- cord-294218-v4gjabp3 31 20 and and CC cord-294218-v4gjabp3 31 21 gp gp NN cord-294218-v4gjabp3 31 22 118 118 CD cord-294218-v4gjabp3 31 23 ( ( -LRB- cord-294218-v4gjabp3 31 24 disulfide disulfide RB cord-294218-v4gjabp3 31 25 - - HYPH cord-294218-v4gjabp3 31 26 linked link VBN cord-294218-v4gjabp3 31 27 dimer dimer NN cord-294218-v4gjabp3 31 28 ) ) -RRB- cord-294218-v4gjabp3 31 29 [ [ -LRB- cord-294218-v4gjabp3 31 30 9 9 CD cord-294218-v4gjabp3 31 31 , , , cord-294218-v4gjabp3 31 32 10 10 CD cord-294218-v4gjabp3 31 33 ] ] -RRB- cord-294218-v4gjabp3 31 34 . . . cord-294218-v4gjabp3 32 1 The the DT cord-294218-v4gjabp3 32 2 N n CD cord-294218-v4gjabp3 32 3 - - HYPH cord-294218-v4gjabp3 32 4 terminal terminal NN cord-294218-v4gjabp3 32 5 regions region NNS cord-294218-v4gjabp3 32 6 of of IN cord-294218-v4gjabp3 32 7 the the DT cord-294218-v4gjabp3 32 8 matrix matrix NN cord-294218-v4gjabp3 32 9 E e NN cord-294218-v4gjabp3 32 10 1 1 CD cord-294218-v4gjabp3 32 11 proteins protein NNS cord-294218-v4gjabp3 32 12 of of IN cord-294218-v4gjabp3 32 13 MHV MHV NNP cord-294218-v4gjabp3 32 14 and and CC cord-294218-v4gjabp3 32 15 BCV BCV NNP cord-294218-v4gjabp3 32 16 bear bear VBP cord-294218-v4gjabp3 32 17 oligosaccharides oligosaccharides NN cord-294218-v4gjabp3 32 18 chains chain NNS cord-294218-v4gjabp3 32 19 that that WDT cord-294218-v4gjabp3 32 20 lack lack VBP cord-294218-v4gjabp3 32 21 mannose mannose NN cord-294218-v4gjabp3 32 22 and and CC cord-294218-v4gjabp3 32 23 fucose fucose JJ cord-294218-v4gjabp3 32 24 , , , cord-294218-v4gjabp3 32 25 and and CC cord-294218-v4gjabp3 32 26 are be VBP cord-294218-v4gjabp3 32 27 O o NN cord-294218-v4gjabp3 32 28 - - HYPH cord-294218-v4gjabp3 32 29 linked link VBN cord-294218-v4gjabp3 32 30 to to IN cord-294218-v4gjabp3 32 31 serine serine NN cord-294218-v4gjabp3 32 32 or or CC cord-294218-v4gjabp3 32 33 threonine threonine NN cord-294218-v4gjabp3 32 34 residues residue NNS cord-294218-v4gjabp3 32 35 , , , cord-294218-v4gjabp3 32 36 an an DT cord-294218-v4gjabp3 32 37 unusual unusual JJ cord-294218-v4gjabp3 32 38 feature feature NN cord-294218-v4gjabp3 32 39 among among IN cord-294218-v4gjabp3 32 40 viral viral JJ cord-294218-v4gjabp3 32 41 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 32 42 [ [ -LRB- cord-294218-v4gjabp3 32 43 18 18 CD cord-294218-v4gjabp3 32 44 , , , cord-294218-v4gjabp3 32 45 22 22 CD cord-294218-v4gjabp3 32 46 , , , cord-294218-v4gjabp3 32 47 27 27 CD cord-294218-v4gjabp3 32 48 ] ] -RRB- cord-294218-v4gjabp3 32 49 . . . cord-294218-v4gjabp3 33 1 Therefore therefore RB cord-294218-v4gjabp3 33 2 , , , cord-294218-v4gjabp3 33 3 the the DT cord-294218-v4gjabp3 33 4 glycosylation glycosylation NN cord-294218-v4gjabp3 33 5 process process NN cord-294218-v4gjabp3 33 6 of of IN cord-294218-v4gjabp3 33 7 the the DT cord-294218-v4gjabp3 33 8 p20 p20 NNP cord-294218-v4gjabp3 33 9 - - HYPH cord-294218-v4gjabp3 33 10 23 23 CD cord-294218-v4gjabp3 33 11 intracellular intracellular JJ cord-294218-v4gjabp3 33 12 precursors precursor NNS cord-294218-v4gjabp3 33 13 does do VBZ cord-294218-v4gjabp3 33 14 not not RB cord-294218-v4gjabp3 33 15 depend depend VB cord-294218-v4gjabp3 33 16 on on IN cord-294218-v4gjabp3 33 17 transfer transfer NN cord-294218-v4gjabp3 33 18 of of IN cord-294218-v4gjabp3 33 19 oligosaccharides oligosaccharide NNS cord-294218-v4gjabp3 33 20 from from IN cord-294218-v4gjabp3 33 21 dolichol dolichol JJ cord-294218-v4gjabp3 33 22 phosphate phosphate NN cord-294218-v4gjabp3 33 23 intermediates intermediate NNS cord-294218-v4gjabp3 33 24 and and CC cord-294218-v4gjabp3 33 25 is be VBZ cord-294218-v4gjabp3 33 26 not not RB cord-294218-v4gjabp3 33 27 inhibited inhibit VBN cord-294218-v4gjabp3 33 28 by by IN cord-294218-v4gjabp3 33 29 tunicamycin tunicamycin NNS cord-294218-v4gjabp3 33 30 , , , cord-294218-v4gjabp3 33 31 but but CC cord-294218-v4gjabp3 33 32 by by IN cord-294218-v4gjabp3 33 33 sodium sodium NN cord-294218-v4gjabp3 33 34 monensin monensin NNP cord-294218-v4gjabp3 33 35 , , , cord-294218-v4gjabp3 33 36 an an DT cord-294218-v4gjabp3 33 37 inhibitor inhibitor NN cord-294218-v4gjabp3 33 38 of of IN cord-294218-v4gjabp3 33 39 the the DT cord-294218-v4gjabp3 33 40 Golgi Golgi NNP cord-294218-v4gjabp3 33 41 function function NN cord-294218-v4gjabp3 33 42 [ [ -LRB- cord-294218-v4gjabp3 33 43 18 18 CD cord-294218-v4gjabp3 33 44 , , , cord-294218-v4gjabp3 33 45 27 27 CD cord-294218-v4gjabp3 33 46 ] ] -RRB- cord-294218-v4gjabp3 33 47 . . . cord-294218-v4gjabp3 34 1 The the DT cord-294218-v4gjabp3 34 2 matrix matrix NN cord-294218-v4gjabp3 34 3 glycoprotein glycoprotein NN cord-294218-v4gjabp3 34 4 of of IN cord-294218-v4gjabp3 34 5 the the DT cord-294218-v4gjabp3 34 6 avian avian JJ cord-294218-v4gjabp3 34 7 infectious infectious JJ cord-294218-v4gjabp3 34 8 bronchitis bronchitis NN cord-294218-v4gjabp3 34 9 virus virus NN cord-294218-v4gjabp3 34 10 ( ( -LRB- cord-294218-v4gjabp3 34 11 IBV IBV NNP cord-294218-v4gjabp3 34 12 ) ) -RRB- cord-294218-v4gjabp3 34 13 and and CC cord-294218-v4gjabp3 34 14 the the DT cord-294218-v4gjabp3 34 15 porcine porcine JJ cord-294218-v4gjabp3 34 16 transmissible transmissible JJ cord-294218-v4gjabp3 34 17 gastroenteritis gastroenteritis NN cord-294218-v4gjabp3 34 18 virus virus NN cord-294218-v4gjabp3 34 19 ( ( -LRB- cord-294218-v4gjabp3 34 20 TGEV TGEV NNP cord-294218-v4gjabp3 34 21 ) ) -RRB- cord-294218-v4gjabp3 34 22 , , , cord-294218-v4gjabp3 34 23 unlike unlike IN cord-294218-v4gjabp3 34 24 that that DT cord-294218-v4gjabp3 34 25 of of IN cord-294218-v4gjabp3 34 26 MHV MHV NNP cord-294218-v4gjabp3 34 27 and and CC cord-294218-v4gjabp3 34 28 BCV BCV NNP cord-294218-v4gjabp3 34 29 , , , cord-294218-v4gjabp3 34 30 has have VBZ cord-294218-v4gjabp3 34 31 N n CD cord-294218-v4gjabp3 34 32 - - HYPH cord-294218-v4gjabp3 34 33 linked link VBN cord-294218-v4gjabp3 34 34 complex complex JJ cord-294218-v4gjabp3 34 35 oligosaccharides oligosaccharide NNS cord-294218-v4gjabp3 34 36 like like IN cord-294218-v4gjabp3 34 37 those those DT cord-294218-v4gjabp3 34 38 found find VBN cord-294218-v4gjabp3 34 39 on on IN cord-294218-v4gjabp3 34 40 the the DT cord-294218-v4gjabp3 34 41 peplomeric peplomeric JJ cord-294218-v4gjabp3 34 42 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 34 43 [ [ -LRB- cord-294218-v4gjabp3 34 44 3 3 CD cord-294218-v4gjabp3 34 45 , , , cord-294218-v4gjabp3 34 46 19 19 CD cord-294218-v4gjabp3 34 47 , , , cord-294218-v4gjabp3 34 48 37 37 CD cord-294218-v4gjabp3 34 49 ] ] -RRB- cord-294218-v4gjabp3 34 50 . . . cord-294218-v4gjabp3 35 1 Indeed indeed RB cord-294218-v4gjabp3 35 2 , , , cord-294218-v4gjabp3 35 3 two two CD cord-294218-v4gjabp3 35 4 potential potential JJ cord-294218-v4gjabp3 35 5 N n CD cord-294218-v4gjabp3 35 6 - - HYPH cord-294218-v4gjabp3 35 7 glycosylated glycosylate VBN cord-294218-v4gjabp3 35 8 sites site NNS cord-294218-v4gjabp3 35 9 are be VBP cord-294218-v4gjabp3 35 10 available available JJ cord-294218-v4gjabp3 35 11 near near IN cord-294218-v4gjabp3 35 12 the the DT cord-294218-v4gjabp3 35 13 N n CD cord-294218-v4gjabp3 35 14 - - HYPH cord-294218-v4gjabp3 35 15 terminus terminus NN cord-294218-v4gjabp3 35 16 of of IN cord-294218-v4gjabp3 35 17 the the DT cord-294218-v4gjabp3 35 18 sequence sequence NN cord-294218-v4gjabp3 35 19 of of IN cord-294218-v4gjabp3 35 20 the the DT cord-294218-v4gjabp3 35 21 E e NN cord-294218-v4gjabp3 35 22 1 1 CD cord-294218-v4gjabp3 35 23 gene gene NN cord-294218-v4gjabp3 35 24 of of IN cord-294218-v4gjabp3 35 25 both both DT cord-294218-v4gjabp3 35 26 viruses virus NNS cord-294218-v4gjabp3 35 27 [ [ -LRB- cord-294218-v4gjabp3 35 28 2 2 CD cord-294218-v4gjabp3 35 29 , , , cord-294218-v4gjabp3 35 30 19 19 CD cord-294218-v4gjabp3 35 31 ] ] -RRB- cord-294218-v4gjabp3 35 32 . . . cord-294218-v4gjabp3 36 1 The the DT cord-294218-v4gjabp3 36 2 significance significance NN cord-294218-v4gjabp3 36 3 of of IN cord-294218-v4gjabp3 36 4 this this DT cord-294218-v4gjabp3 36 5 diversity diversity NN cord-294218-v4gjabp3 36 6 of of IN cord-294218-v4gjabp3 36 7 glycosylation glycosylation NN cord-294218-v4gjabp3 36 8 patterns pattern NNS cord-294218-v4gjabp3 36 9 among among IN cord-294218-v4gjabp3 36 10 coronaviruses coronaviruse NNS cord-294218-v4gjabp3 36 11 is be VBZ cord-294218-v4gjabp3 36 12 not not RB cord-294218-v4gjabp3 36 13 known know VBN cord-294218-v4gjabp3 36 14 . . . cord-294218-v4gjabp3 37 1 Turkey Turkey NNP cord-294218-v4gjabp3 37 2 enteric enteric JJ cord-294218-v4gjabp3 37 3 coronavirus coronavirus NN cord-294218-v4gjabp3 37 4 ( ( -LRB- cord-294218-v4gjabp3 37 5 TCV TCV NNP cord-294218-v4gjabp3 37 6 ) ) -RRB- cord-294218-v4gjabp3 37 7 , , , cord-294218-v4gjabp3 37 8 a a DT cord-294218-v4gjabp3 37 9 major major JJ cord-294218-v4gjabp3 37 10 etiological etiological JJ cord-294218-v4gjabp3 37 11 agent agent NN cord-294218-v4gjabp3 37 12 of of IN cord-294218-v4gjabp3 37 13 epidemic epidemic JJ cord-294218-v4gjabp3 37 14 diarrhea diarrhea NN cord-294218-v4gjabp3 37 15 in in IN cord-294218-v4gjabp3 37 16 turkey turkey NN cord-294218-v4gjabp3 37 17 poults poult NNS cord-294218-v4gjabp3 37 18 [ [ -LRB- cord-294218-v4gjabp3 38 1 5 5 CD cord-294218-v4gjabp3 38 2 , , , cord-294218-v4gjabp3 38 3 25 25 CD cord-294218-v4gjabp3 38 4 ] ] -RRB- cord-294218-v4gjabp3 38 5 , , , cord-294218-v4gjabp3 38 6 possesses possess VBZ cord-294218-v4gjabp3 38 7 an an DT cord-294218-v4gjabp3 38 8 hemagglutinating hemagglutinate VBG cord-294218-v4gjabp3 38 9 activity activity NN cord-294218-v4gjabp3 38 10 , , , cord-294218-v4gjabp3 38 11 surface surface NN cord-294218-v4gjabp3 38 12 projections projection NNS cord-294218-v4gjabp3 38 13 of of IN cord-294218-v4gjabp3 38 14 two two CD cord-294218-v4gjabp3 38 15 different different JJ cord-294218-v4gjabp3 38 16 types type NNS cord-294218-v4gjabp3 38 17 , , , cord-294218-v4gjabp3 38 18 and and CC cord-294218-v4gjabp3 38 19 biochemical biochemical JJ cord-294218-v4gjabp3 38 20 characteristics characteristic NNS cord-294218-v4gjabp3 38 21 that that WDT cord-294218-v4gjabp3 38 22 resemble resemble VBP cord-294218-v4gjabp3 38 23 those those DT cord-294218-v4gjabp3 38 24 of of IN cord-294218-v4gjabp3 38 25 mammalian mammalian JJ cord-294218-v4gjabp3 38 26 hemagglutinating hemagglutinating NN cord-294218-v4gjabp3 38 27 coronaviruses coronaviruse NNS cord-294218-v4gjabp3 38 28 [ [ -LRB- cord-294218-v4gjabp3 38 29 4 4 CD cord-294218-v4gjabp3 38 30 , , , cord-294218-v4gjabp3 38 31 6 6 CD cord-294218-v4gjabp3 38 32 , , , cord-294218-v4gjabp3 38 33 17 17 CD cord-294218-v4gjabp3 38 34 , , , cord-294218-v4gjabp3 38 35 19 19 CD cord-294218-v4gjabp3 38 36 ] ] -RRB- cord-294218-v4gjabp3 38 37 . . . cord-294218-v4gjabp3 39 1 TCV TCV NNP cord-294218-v4gjabp3 39 2 isolates isolate VBZ cord-294218-v4gjabp3 39 3 also also RB cord-294218-v4gjabp3 39 4 can can MD cord-294218-v4gjabp3 39 5 be be VB cord-294218-v4gjabp3 39 6 propagated propagate VBN cord-294218-v4gjabp3 39 7 in in IN cord-294218-v4gjabp3 39 8 HRT-18 HRT-18 NNP cord-294218-v4gjabp3 39 9 cells cell NNS cord-294218-v4gjabp3 39 10 , , , cord-294218-v4gjabp3 39 11 an an DT cord-294218-v4gjabp3 39 12 established establish VBN cord-294218-v4gjabp3 39 13 cell cell NN cord-294218-v4gjabp3 39 14 line line NN cord-294218-v4gjabp3 39 15 originated originate VBD cord-294218-v4gjabp3 39 16 from from IN cord-294218-v4gjabp3 39 17 a a DT cord-294218-v4gjabp3 39 18 human human JJ cord-294218-v4gjabp3 39 19 rectal rectal JJ cord-294218-v4gjabp3 39 20 adenocarcinoma adenocarcinoma NN cord-294218-v4gjabp3 39 21 [ [ -LRB- cord-294218-v4gjabp3 39 22 4 4 CD cord-294218-v4gjabp3 39 23 , , , cord-294218-v4gjabp3 39 24 7 7 CD cord-294218-v4gjabp3 39 25 , , , cord-294218-v4gjabp3 39 26 15 15 CD cord-294218-v4gjabp3 39 27 , , , cord-294218-v4gjabp3 39 28 17 17 CD cord-294218-v4gjabp3 39 29 ] ] -RRB- cord-294218-v4gjabp3 39 30 . . . cord-294218-v4gjabp3 40 1 In in IN cord-294218-v4gjabp3 40 2 the the DT cord-294218-v4gjabp3 40 3 present present JJ cord-294218-v4gjabp3 40 4 study study NN cord-294218-v4gjabp3 40 5 , , , cord-294218-v4gjabp3 40 6 we -PRON- PRP cord-294218-v4gjabp3 40 7 have have VBP cord-294218-v4gjabp3 40 8 investigated investigate VBN cord-294218-v4gjabp3 40 9 the the DT cord-294218-v4gjabp3 40 10 intracellular intracellular JJ cord-294218-v4gjabp3 40 11 synthesis synthesis NN cord-294218-v4gjabp3 40 12 and and CC cord-294218-v4gjabp3 40 13 post post JJ cord-294218-v4gjabp3 40 14 - - JJ cord-294218-v4gjabp3 40 15 translational translational JJ cord-294218-v4gjabp3 40 16 modifications modification NNS cord-294218-v4gjabp3 40 17 of of IN cord-294218-v4gjabp3 40 18 virus virus NN cord-294218-v4gjabp3 40 19 - - HYPH cord-294218-v4gjabp3 40 20 coded code VBN cord-294218-v4gjabp3 40 21 polypeptides polypeptide NNS cord-294218-v4gjabp3 40 22 in in IN cord-294218-v4gjabp3 40 23 cultures culture NNS cord-294218-v4gjabp3 40 24 of of IN cord-294218-v4gjabp3 40 25 HRT-18 HRT-18 NNP cord-294218-v4gjabp3 40 26 infected infect VBN cord-294218-v4gjabp3 40 27 with with IN cord-294218-v4gjabp3 40 28 TCV TCV NNP cord-294218-v4gjabp3 40 29 in in IN cord-294218-v4gjabp3 40 30 the the DT cord-294218-v4gjabp3 40 31 presence presence NN cord-294218-v4gjabp3 40 32 or or CC cord-294218-v4gjabp3 40 33 the the DT cord-294218-v4gjabp3 40 34 absence absence NN cord-294218-v4gjabp3 40 35 of of IN cord-294218-v4gjabp3 40 36 glycosylation glycosylation NN cord-294218-v4gjabp3 40 37 inhibitors inhibitor NNS cord-294218-v4gjabp3 40 38 . . . cord-294218-v4gjabp3 41 1 Putative putative JJ cord-294218-v4gjabp3 41 2 intracellular intracellular JJ cord-294218-v4gjabp3 41 3 glycosylated glycosylate VBN cord-294218-v4gjabp3 41 4 and and CC cord-294218-v4gjabp3 41 5 unglycosylated unglycosylate VBN cord-294218-v4gjabp3 41 6 precursors precursor NNS cord-294218-v4gjabp3 41 7 have have VBP cord-294218-v4gjabp3 41 8 been be VBN cord-294218-v4gjabp3 41 9 identified identify VBN cord-294218-v4gjabp3 41 10 for for IN cord-294218-v4gjabp3 41 11 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 41 12 associated associate VBN cord-294218-v4gjabp3 41 13 with with IN cord-294218-v4gjabp3 41 14 both both DT cord-294218-v4gjabp3 41 15 types type NNS cord-294218-v4gjabp3 41 16 of of IN cord-294218-v4gjabp3 41 17 surface surface NN cord-294218-v4gjabp3 41 18 projections projection NNS cord-294218-v4gjabp3 41 19 , , , cord-294218-v4gjabp3 41 20 and and CC cord-294218-v4gjabp3 41 21 the the DT cord-294218-v4gjabp3 41 22 matrix matrix NN cord-294218-v4gjabp3 41 23 protein protein NN cord-294218-v4gjabp3 41 24 of of IN cord-294218-v4gjabp3 41 25 T t NN cord-294218-v4gjabp3 41 26 C c NN cord-294218-v4gjabp3 41 27 V v NN cord-294218-v4gjabp3 42 1 was be VBD cord-294218-v4gjabp3 42 2 f f NNP cord-294218-v4gjabp3 42 3 o o NN cord-294218-v4gjabp3 42 4 u u NN cord-294218-v4gjabp3 42 5 n n NN cord-294218-v4gjabp3 42 6 d d NN cord-294218-v4gjabp3 42 7 to to TO cord-294218-v4gjabp3 42 8 be be VB cord-294218-v4gjabp3 42 9 glycosylated glycosylate VBN cord-294218-v4gjabp3 42 10 by by IN cord-294218-v4gjabp3 42 11 a a DT cord-294218-v4gjabp3 42 12 process process NN cord-294218-v4gjabp3 42 13 which which WDT cord-294218-v4gjabp3 42 14 was be VBD cord-294218-v4gjabp3 42 15 sensitive sensitive JJ cord-294218-v4gjabp3 42 16 to to IN cord-294218-v4gjabp3 42 17 tunicamycin tunicamycin NNS cord-294218-v4gjabp3 42 18 , , , cord-294218-v4gjabp3 42 19 but but CC cord-294218-v4gjabp3 42 20 resistant resistant JJ cord-294218-v4gjabp3 42 21 to to IN cord-294218-v4gjabp3 42 22 sodium sodium NN cord-294218-v4gjabp3 42 23 monensin monensin NNP cord-294218-v4gjabp3 42 24 . . . cord-294218-v4gjabp3 43 1 The the DT cord-294218-v4gjabp3 43 2 effects effect NNS cord-294218-v4gjabp3 43 3 of of IN cord-294218-v4gjabp3 43 4 these these DT cord-294218-v4gjabp3 43 5 glycosylation glycosylation NN cord-294218-v4gjabp3 43 6 inhibitors inhibitor NNS cord-294218-v4gjabp3 43 7 on on IN cord-294218-v4gjabp3 43 8 the the DT cord-294218-v4gjabp3 43 9 viral viral JJ cord-294218-v4gjabp3 43 10 morphogenesis morphogenesis NN cord-294218-v4gjabp3 43 11 was be VBD cord-294218-v4gjabp3 43 12 confirmed confirm VBN cord-294218-v4gjabp3 43 13 by by IN cord-294218-v4gjabp3 43 14 electron electron NN cord-294218-v4gjabp3 43 15 microscopy microscopy NN cord-294218-v4gjabp3 43 16 of of IN cord-294218-v4gjabp3 43 17 TCVinfected tcvinfecte VBN cord-294218-v4gjabp3 43 18 cells cell NNS cord-294218-v4gjabp3 43 19 . . . cord-294218-v4gjabp3 44 1 Glycosylation glycosylation NN cord-294218-v4gjabp3 44 2 of of IN cord-294218-v4gjabp3 44 3 the the DT cord-294218-v4gjabp3 44 4 matrix matrix NN cord-294218-v4gjabp3 44 5 protein protein NN cord-294218-v4gjabp3 44 6 was be VBD cord-294218-v4gjabp3 44 7 apparently apparently RB cord-294218-v4gjabp3 44 8 not not RB cord-294218-v4gjabp3 44 9 required require VBN cord-294218-v4gjabp3 44 10 for for IN cord-294218-v4gjabp3 44 11 the the DT cord-294218-v4gjabp3 44 12 formation formation NN cord-294218-v4gjabp3 44 13 of of IN cord-294218-v4gjabp3 44 14 the the DT cord-294218-v4gjabp3 44 15 TCV TCV NNP cord-294218-v4gjabp3 44 16 virions virion NNS cord-294218-v4gjabp3 44 17 . . . cord-294218-v4gjabp3 45 1 The the DT cord-294218-v4gjabp3 45 2 Minnesota Minnesota NNP cord-294218-v4gjabp3 45 3 strain strain NN cord-294218-v4gjabp3 45 4 [ [ -LRB- cord-294218-v4gjabp3 45 5 21 21 CD cord-294218-v4gjabp3 45 6 ] ] -RRB- cord-294218-v4gjabp3 45 7 of of IN cord-294218-v4gjabp3 45 8 TCV TCV NNP cord-294218-v4gjabp3 45 9 and and CC cord-294218-v4gjabp3 45 10 virus virus NN cord-294218-v4gjabp3 45 11 stocks stock NNS cord-294218-v4gjabp3 45 12 were be VBD cord-294218-v4gjabp3 45 13 obtained obtain VBN cord-294218-v4gjabp3 45 14 and and CC cord-294218-v4gjabp3 45 15 propagated propagate VBN cord-294218-v4gjabp3 45 16 in in IN cord-294218-v4gjabp3 45 17 HRT-18 HRT-18 NNP cord-294218-v4gjabp3 45 18 cells cell NNS cord-294218-v4gjabp3 45 19 , , , cord-294218-v4gjabp3 45 20 in in IN cord-294218-v4gjabp3 45 21 the the DT cord-294218-v4gjabp3 45 22 presence presence NN cord-294218-v4gjabp3 45 23 of of IN cord-294218-v4gjabp3 45 24 trypsin trypsin NN cord-294218-v4gjabp3 45 25 , , , cord-294218-v4gjabp3 45 26 as as IN cord-294218-v4gjabp3 45 27 previously previously RB cord-294218-v4gjabp3 45 28 described describe VBN cord-294218-v4gjabp3 45 29 [ [ -LRB- cord-294218-v4gjabp3 45 30 -4 -4 NNP cord-294218-v4gjabp3 45 31 , , , cord-294218-v4gjabp3 45 32 7 7 CD cord-294218-v4gjabp3 45 33 ] ] -RRB- cord-294218-v4gjabp3 45 34 . . . cord-294218-v4gjabp3 46 1 After after IN cord-294218-v4gjabp3 46 2 five five CD cord-294218-v4gjabp3 46 3 successive successive JJ cord-294218-v4gjabp3 46 4 passages passage NNS cord-294218-v4gjabp3 46 5 , , , cord-294218-v4gjabp3 46 6 the the DT cord-294218-v4gjabp3 46 7 virus virus NN cord-294218-v4gjabp3 46 8 was be VBD cord-294218-v4gjabp3 46 9 cloned clone VBN cord-294218-v4gjabp3 46 10 twice twice RB cord-294218-v4gjabp3 46 11 by by IN cord-294218-v4gjabp3 46 12 the the DT cord-294218-v4gjabp3 46 13 limiting limit VBG cord-294218-v4gjabp3 46 14 dilution dilution NN cord-294218-v4gjabp3 46 15 method method NN cord-294218-v4gjabp3 46 16 . . . cord-294218-v4gjabp3 47 1 Cloned clone VBN cord-294218-v4gjabp3 47 2 virus virus NN cord-294218-v4gjabp3 47 3 was be VBD cord-294218-v4gjabp3 47 4 passaged passage VBN cord-294218-v4gjabp3 47 5 at at IN cord-294218-v4gjabp3 47 6 a a DT cord-294218-v4gjabp3 47 7 multiplicity multiplicity NN cord-294218-v4gjabp3 47 8 of of IN cord-294218-v4gjabp3 47 9 infection infection NN cord-294218-v4gjabp3 47 10 of of IN cord-294218-v4gjabp3 47 11 0.1 0.1 CD cord-294218-v4gjabp3 47 12 to to TO cord-294218-v4gjabp3 47 13 5 5 CD cord-294218-v4gjabp3 47 14 TCID TCID NNP cord-294218-v4gjabp3 47 15 50 50 CD cord-294218-v4gjabp3 47 16 per per IN cord-294218-v4gjabp3 47 17 cell cell NN cord-294218-v4gjabp3 47 18 . . . cord-294218-v4gjabp3 48 1 The the DT cord-294218-v4gjabp3 48 2 origin origin NN cord-294218-v4gjabp3 48 3 of of IN cord-294218-v4gjabp3 48 4 the the DT cord-294218-v4gjabp3 48 5 rabbit rabbit NN cord-294218-v4gjabp3 48 6 anti anti NNP cord-294218-v4gjabp3 48 7 - - NNP cord-294218-v4gjabp3 48 8 TCV TCV NNP cord-294218-v4gjabp3 48 9 hyperimmune hyperimmune NNP cord-294218-v4gjabp3 48 10 serum serum NN cord-294218-v4gjabp3 48 11 was be VBD cord-294218-v4gjabp3 48 12 described describe VBN cord-294218-v4gjabp3 48 13 previously previously RB cord-294218-v4gjabp3 48 14 [ [ -LRB- cord-294218-v4gjabp3 48 15 4 4 CD cord-294218-v4gjabp3 48 16 ] ] -RRB- cord-294218-v4gjabp3 48 17 . . . cord-294218-v4gjabp3 49 1 To to TO cord-294218-v4gjabp3 49 2 analyse analyse VB cord-294218-v4gjabp3 49 3 intracellular intracellular JJ cord-294218-v4gjabp3 49 4 synthesis synthesis NN cord-294218-v4gjabp3 49 5 of of IN cord-294218-v4gjabp3 49 6 viral viral JJ cord-294218-v4gjabp3 49 7 polypeptides polypeptide NNS cord-294218-v4gjabp3 49 8 , , , cord-294218-v4gjabp3 49 9 HRT-18 HRT-18 NNP cord-294218-v4gjabp3 49 10 cells cell NNS cord-294218-v4gjabp3 49 11 were be VBD cord-294218-v4gjabp3 49 12 infected infect VBN cord-294218-v4gjabp3 49 13 at at IN cord-294218-v4gjabp3 49 14 a a DT cord-294218-v4gjabp3 49 15 multiplicity multiplicity NN cord-294218-v4gjabp3 49 16 of of IN cord-294218-v4gjabp3 49 17 10 10 CD cord-294218-v4gjabp3 49 18 TCID TCID NNP cord-294218-v4gjabp3 49 19 50 50 CD cord-294218-v4gjabp3 49 20 / / SYM cord-294218-v4gjabp3 49 21 cell cell NN cord-294218-v4gjabp3 49 22 . . . cord-294218-v4gjabp3 50 1 At at IN cord-294218-v4gjabp3 50 2 given give VBN cord-294218-v4gjabp3 50 3 times time NNS cord-294218-v4gjabp3 50 4 , , , cord-294218-v4gjabp3 50 5 indicated indicate VBN cord-294218-v4gjabp3 50 6 in in IN cord-294218-v4gjabp3 50 7 Results result NNS cord-294218-v4gjabp3 50 8 and and CC cord-294218-v4gjabp3 50 9 figure figure NN cord-294218-v4gjabp3 50 10 legends legend NNS cord-294218-v4gjabp3 50 11 , , , cord-294218-v4gjabp3 50 12 the the DT cord-294218-v4gjabp3 50 13 maintenance maintenance NN cord-294218-v4gjabp3 50 14 medium medium NN cord-294218-v4gjabp3 50 15 was be VBD cord-294218-v4gjabp3 50 16 replaced replace VBN cord-294218-v4gjabp3 50 17 by by IN cord-294218-v4gjabp3 50 18 medium medium NN cord-294218-v4gjabp3 50 19 without without IN cord-294218-v4gjabp3 50 20 methionine methionine NN cord-294218-v4gjabp3 50 21 . . . cord-294218-v4gjabp3 51 1 After after IN cord-294218-v4gjabp3 51 2 30 30 CD cord-294218-v4gjabp3 51 3 min min NN cord-294218-v4gjabp3 51 4 of of IN cord-294218-v4gjabp3 51 5 methionine methionine JJ cord-294218-v4gjabp3 51 6 starvation starvation NN cord-294218-v4gjabp3 51 7 , , , cord-294218-v4gjabp3 51 8 the the DT cord-294218-v4gjabp3 51 9 cells cell NNS cord-294218-v4gjabp3 51 10 were be VBD cord-294218-v4gjabp3 51 11 pulse pulse NN cord-294218-v4gjabp3 51 12 - - HYPH cord-294218-v4gjabp3 51 13 labeled label VBN cord-294218-v4gjabp3 51 14 for for IN cord-294218-v4gjabp3 51 15 30 30 CD cord-294218-v4gjabp3 51 16 min min NN cord-294218-v4gjabp3 51 17 by by IN cord-294218-v4gjabp3 51 18 the the DT cord-294218-v4gjabp3 51 19 addition addition NN cord-294218-v4gjabp3 51 20 of of IN cord-294218-v4gjabp3 51 21 1 1 CD cord-294218-v4gjabp3 51 22 ml ml NN cord-294218-v4gjabp3 51 23 / / SYM cord-294218-v4gjabp3 51 24 flask flask NN cord-294218-v4gjabp3 51 25 of of IN cord-294218-v4gjabp3 51 26 methionine methionine NN cord-294218-v4gjabp3 51 27 - - HYPH cord-294218-v4gjabp3 51 28 free free JJ cord-294218-v4gjabp3 51 29 RPMI RPMI NNP cord-294218-v4gjabp3 51 30 containing contain VBG cord-294218-v4gjabp3 51 31 50gCi 50gci CD cord-294218-v4gjabp3 51 32 / / SYM cord-294218-v4gjabp3 51 33 ml ml NN cord-294218-v4gjabp3 51 34 [ [ -LRB- cord-294218-v4gjabp3 51 35 35S]methionine 35s]methionine CD cord-294218-v4gjabp3 51 36 . . . cord-294218-v4gjabp3 52 1 Replicate replicate VB cord-294218-v4gjabp3 52 2 cultures culture NNS cord-294218-v4gjabp3 52 3 were be VBD cord-294218-v4gjabp3 52 4 chased chase VBN cord-294218-v4gjabp3 52 5 for for IN cord-294218-v4gjabp3 52 6 1 1 CD cord-294218-v4gjabp3 52 7 hour hour NN cord-294218-v4gjabp3 52 8 by by IN cord-294218-v4gjabp3 52 9 replacing replace VBG cord-294218-v4gjabp3 52 10 pulse pulse NN cord-294218-v4gjabp3 52 11 - - HYPH cord-294218-v4gjabp3 52 12 medium medium NN cord-294218-v4gjabp3 52 13 with with IN cord-294218-v4gjabp3 52 14 complete complete JJ cord-294218-v4gjabp3 52 15 RPMI RPMI NNP cord-294218-v4gjabp3 52 16 containing contain VBG cord-294218-v4gjabp3 52 17 5 5 CD cord-294218-v4gjabp3 52 18 % % NN cord-294218-v4gjabp3 52 19 FBS FBS NNP cord-294218-v4gjabp3 52 20 and and CC cord-294218-v4gjabp3 52 21 then then RB cord-294218-v4gjabp3 52 22 harvested harvest VBN cord-294218-v4gjabp3 52 23 in in IN cord-294218-v4gjabp3 52 24 ice ice NN cord-294218-v4gjabp3 52 25 - - HYPH cord-294218-v4gjabp3 52 26 cold cold JJ cord-294218-v4gjabp3 52 27 PBS PBS NNP cord-294218-v4gjabp3 52 28 . . . cord-294218-v4gjabp3 53 1 In in IN cord-294218-v4gjabp3 53 2 experiments experiment NNS cord-294218-v4gjabp3 53 3 where where WRB cord-294218-v4gjabp3 53 4 tunicamycin tunicamycin NNS cord-294218-v4gjabp3 53 5 ( ( -LRB- cord-294218-v4gjabp3 53 6 0.01 0.01 CD cord-294218-v4gjabp3 53 7 to to IN cord-294218-v4gjabp3 53 8 10.0 10.0 CD cord-294218-v4gjabp3 53 9 gg/ gg/ NNS cord-294218-v4gjabp3 53 10 ml ml NNP cord-294218-v4gjabp3 53 11 ) ) -RRB- cord-294218-v4gjabp3 53 12 or or CC cord-294218-v4gjabp3 53 13 sodium sodium NN cord-294218-v4gjabp3 53 14 monensin monensin NNP cord-294218-v4gjabp3 53 15 ( ( -LRB- cord-294218-v4gjabp3 53 16 0.5 0.5 CD cord-294218-v4gjabp3 53 17 to to TO cord-294218-v4gjabp3 53 18 5 5 CD cord-294218-v4gjabp3 53 19 gM gM NNP cord-294218-v4gjabp3 53 20 ) ) -RRB- cord-294218-v4gjabp3 53 21 was be VBD cord-294218-v4gjabp3 53 22 used use VBN cord-294218-v4gjabp3 53 23 , , , cord-294218-v4gjabp3 53 24 the the DT cord-294218-v4gjabp3 53 25 inhibitor inhibitor NN cord-294218-v4gjabp3 53 26 was be VBD cord-294218-v4gjabp3 53 27 added add VBN cord-294218-v4gjabp3 53 28 at at IN cord-294218-v4gjabp3 53 29 the the DT cord-294218-v4gjabp3 53 30 beginning beginning NN cord-294218-v4gjabp3 53 31 of of IN cord-294218-v4gjabp3 53 32 the the DT cord-294218-v4gjabp3 53 33 starvation starvation NN cord-294218-v4gjabp3 53 34 period period NN cord-294218-v4gjabp3 53 35 and and CC cord-294218-v4gjabp3 53 36 was be VBD cord-294218-v4gjabp3 53 37 present present JJ cord-294218-v4gjabp3 53 38 throughout throughout IN cord-294218-v4gjabp3 53 39 the the DT cord-294218-v4gjabp3 53 40 rest rest NN cord-294218-v4gjabp3 53 41 of of IN cord-294218-v4gjabp3 53 42 the the DT cord-294218-v4gjabp3 53 43 experiment experiment NN cord-294218-v4gjabp3 53 44 . . . cord-294218-v4gjabp3 54 1 For for IN cord-294218-v4gjabp3 54 2 pulse pulse NN cord-294218-v4gjabp3 54 3 - - HYPH cord-294218-v4gjabp3 54 4 chase chase NN cord-294218-v4gjabp3 54 5 labeling labeling NN cord-294218-v4gjabp3 54 6 of of IN cord-294218-v4gjabp3 54 7 intracellular intracellular JJ cord-294218-v4gjabp3 54 8 polypeptides polypeptide NNS cord-294218-v4gjabp3 54 9 , , , cord-294218-v4gjabp3 54 10 the the DT cord-294218-v4gjabp3 54 11 infected infected JJ cord-294218-v4gjabp3 54 12 cells cell NNS cord-294218-v4gjabp3 54 13 were be VBD cord-294218-v4gjabp3 54 14 starved starve VBN cord-294218-v4gjabp3 54 15 for for IN cord-294218-v4gjabp3 54 16 methionine methionine NN cord-294218-v4gjabp3 54 17 for for IN cord-294218-v4gjabp3 54 18 30min 30min NN cord-294218-v4gjabp3 54 19 and and CC cord-294218-v4gjabp3 54 20 then then RB cord-294218-v4gjabp3 54 21 labeled label VBN cord-294218-v4gjabp3 54 22 by by IN cord-294218-v4gjabp3 54 23 adding add VBG cord-294218-v4gjabp3 54 24 50 50 CD cord-294218-v4gjabp3 55 1 ~tCi ~tCi NNP cord-294218-v4gjabp3 55 2 / / SYM cord-294218-v4gjabp3 55 3 ml ml NNS cord-294218-v4gjabp3 55 4 of of IN cord-294218-v4gjabp3 55 5 [ [ -LRB- cord-294218-v4gjabp3 55 6 35S]methionine 35s]methionine CD cord-294218-v4gjabp3 55 7 to to IN cord-294218-v4gjabp3 55 8 methionine methionine NN cord-294218-v4gjabp3 55 9 - - HYPH cord-294218-v4gjabp3 55 10 free free JJ cord-294218-v4gjabp3 55 11 medium medium NN cord-294218-v4gjabp3 55 12 , , , cord-294218-v4gjabp3 56 1 beginning begin VBG cord-294218-v4gjabp3 56 2 at at IN cord-294218-v4gjabp3 56 3 6 6 CD cord-294218-v4gjabp3 56 4 to to TO cord-294218-v4gjabp3 56 5 9 9 CD cord-294218-v4gjabp3 56 6 hours hour NNS cord-294218-v4gjabp3 56 7 p.i p.i NNP cord-294218-v4gjabp3 56 8 . . NNP cord-294218-v4gjabp3 56 9 for for IN cord-294218-v4gjabp3 56 10 different different JJ cord-294218-v4gjabp3 56 11 experiments experiment NNS cord-294218-v4gjabp3 56 12 . . . cord-294218-v4gjabp3 57 1 After after IN cord-294218-v4gjabp3 57 2 a a DT cord-294218-v4gjabp3 57 3 30 30 CD cord-294218-v4gjabp3 57 4 min min NN cord-294218-v4gjabp3 57 5 pulse pulse NN cord-294218-v4gjabp3 57 6 period period NN cord-294218-v4gjabp3 57 7 , , , cord-294218-v4gjabp3 57 8 the the DT cord-294218-v4gjabp3 57 9 cells cell NNS cord-294218-v4gjabp3 57 10 were be VBD cord-294218-v4gjabp3 57 11 rinsed rinse VBN cord-294218-v4gjabp3 57 12 twice twice RB cord-294218-v4gjabp3 57 13 in in IN cord-294218-v4gjabp3 57 14 complete complete JJ cord-294218-v4gjabp3 57 15 RPMI RPMI NNP cord-294218-v4gjabp3 57 16 and and CC cord-294218-v4gjabp3 57 17 then then RB cord-294218-v4gjabp3 57 18 further further RB cord-294218-v4gjabp3 57 19 incubated incubate VBN cord-294218-v4gjabp3 57 20 with with IN cord-294218-v4gjabp3 57 21 this this DT cord-294218-v4gjabp3 57 22 medium medium NN cord-294218-v4gjabp3 57 23 for for IN cord-294218-v4gjabp3 57 24 15 15 CD cord-294218-v4gjabp3 57 25 rain rain NN cord-294218-v4gjabp3 57 26 to to IN cord-294218-v4gjabp3 57 27 4 4 CD cord-294218-v4gjabp3 57 28 h h NN cord-294218-v4gjabp3 57 29 before before IN cord-294218-v4gjabp3 57 30 harvesting harvest VBG cord-294218-v4gjabp3 57 31 . . . cord-294218-v4gjabp3 58 1 The the DT cord-294218-v4gjabp3 58 2 cell cell NN cord-294218-v4gjabp3 58 3 sheets sheet NNS cord-294218-v4gjabp3 58 4 were be VBD cord-294218-v4gjabp3 58 5 rinsed rinse VBN cord-294218-v4gjabp3 58 6 twice twice RB cord-294218-v4gjabp3 58 7 in in IN cord-294218-v4gjabp3 58 8 PBS PBS NNP cord-294218-v4gjabp3 58 9 , , , cord-294218-v4gjabp3 58 10 and and CC cord-294218-v4gjabp3 58 11 scraped scrape VBD cord-294218-v4gjabp3 58 12 into into IN cord-294218-v4gjabp3 58 13 ice ice NN cord-294218-v4gjabp3 58 14 - - HYPH cord-294218-v4gjabp3 58 15 cold cold JJ cord-294218-v4gjabp3 58 16 lysis lysis NN cord-294218-v4gjabp3 58 17 buffer buffer NN cord-294218-v4gjabp3 58 18 ( ( -LRB- cord-294218-v4gjabp3 58 19 RIPA RIPA NNP cord-294218-v4gjabp3 58 20 ) ) -RRB- cord-294218-v4gjabp3 58 21 made make VBN cord-294218-v4gjabp3 58 22 of of IN cord-294218-v4gjabp3 58 23 20 20 CD cord-294218-v4gjabp3 58 24 mM mM NNP cord-294218-v4gjabp3 58 25 Tris Tris NNP cord-294218-v4gjabp3 58 26 - - HYPH cord-294218-v4gjabp3 58 27 HC1 HC1 NNP cord-294218-v4gjabp3 58 28 , , , cord-294218-v4gjabp3 58 29 pH pH NNP cord-294218-v4gjabp3 58 30 6.8 6.8 CD cord-294218-v4gjabp3 58 31 , , , cord-294218-v4gjabp3 58 32 150 150 CD cord-294218-v4gjabp3 58 33 mM mm CD cord-294218-v4gjabp3 58 34 NaC1 NaC1 NNPS cord-294218-v4gjabp3 58 35 , , , cord-294218-v4gjabp3 58 36 1 1 CD cord-294218-v4gjabp3 58 37 mM mm CD cord-294218-v4gjabp3 58 38 EDTA EDTA NNP cord-294218-v4gjabp3 58 39 , , , cord-294218-v4gjabp3 58 40 0.6 0.6 CD cord-294218-v4gjabp3 58 41 M M NNP cord-294218-v4gjabp3 58 42 KC1 KC1 NNP cord-294218-v4gjabp3 58 43 , , , cord-294218-v4gjabp3 58 44 0.5mM 0.5mm CD cord-294218-v4gjabp3 58 45 MgC12 MgC12 NNP cord-294218-v4gjabp3 58 46 , , , cord-294218-v4gjabp3 58 47 1 1 CD cord-294218-v4gjabp3 58 48 % % NN cord-294218-v4gjabp3 58 49 Triton Triton NNP cord-294218-v4gjabp3 58 50 X-100 x-100 NN cord-294218-v4gjabp3 58 51 , , , cord-294218-v4gjabp3 58 52 0.1 0.1 CD cord-294218-v4gjabp3 58 53 % % NN cord-294218-v4gjabp3 58 54 SDS SDS NNP cord-294218-v4gjabp3 58 55 , , , cord-294218-v4gjabp3 58 56 1 1 CD cord-294218-v4gjabp3 58 57 % % NN cord-294218-v4gjabp3 58 58 NP40 NP40 NNP cord-294218-v4gjabp3 58 59 , , , cord-294218-v4gjabp3 58 60 103 103 CD cord-294218-v4gjabp3 58 61 units unit NNS cord-294218-v4gjabp3 58 62 aprotinin aprotinin NNP cord-294218-v4gjabp3 58 63 / / SYM cord-294218-v4gjabp3 58 64 ml ml NN cord-294218-v4gjabp3 58 65 and and CC cord-294218-v4gjabp3 58 66 200gg 200gg JJ cord-294218-v4gjabp3 58 67 PMSF PMSF NNP cord-294218-v4gjabp3 58 68 / / SYM cord-294218-v4gjabp3 58 69 ml ml NN cord-294218-v4gjabp3 58 70 . . . cord-294218-v4gjabp3 59 1 The the DT cord-294218-v4gjabp3 59 2 cell cell NN cord-294218-v4gjabp3 59 3 lysate lysate NN cord-294218-v4gjabp3 59 4 was be VBD cord-294218-v4gjabp3 59 5 immediately immediately RB cord-294218-v4gjabp3 59 6 passed pass VBN cord-294218-v4gjabp3 59 7 10 10 CD cord-294218-v4gjabp3 59 8 times time NNS cord-294218-v4gjabp3 59 9 through through IN cord-294218-v4gjabp3 59 10 a a DT cord-294218-v4gjabp3 59 11 26-Gauge 26-gauge CD cord-294218-v4gjabp3 59 12 syringe syringe NN cord-294218-v4gjabp3 59 13 needle needle NN cord-294218-v4gjabp3 59 14 , , , cord-294218-v4gjabp3 59 15 heated heat VBN cord-294218-v4gjabp3 59 16 to to IN cord-294218-v4gjabp3 59 17 100 100 CD cord-294218-v4gjabp3 59 18 ° ° NN cord-294218-v4gjabp3 59 19 C c NN cord-294218-v4gjabp3 59 20 for for IN cord-294218-v4gjabp3 59 21 3 3 CD cord-294218-v4gjabp3 59 22 rain rain NN cord-294218-v4gjabp3 59 23 , , , cord-294218-v4gjabp3 59 24 clarified clarify VBN cord-294218-v4gjabp3 59 25 by by IN cord-294218-v4gjabp3 59 26 centrifugation centrifugation NN cord-294218-v4gjabp3 59 27 at at IN cord-294218-v4gjabp3 59 28 15,000 15,000 CD cord-294218-v4gjabp3 59 29 x x SYM cord-294218-v4gjabp3 59 30 g g NN cord-294218-v4gjabp3 59 31 for for IN cord-294218-v4gjabp3 59 32 20min 20min NN cord-294218-v4gjabp3 59 33 , , , cord-294218-v4gjabp3 59 34 and and CC cord-294218-v4gjabp3 59 35 stored store VBN cord-294218-v4gjabp3 59 36 at at IN cord-294218-v4gjabp3 59 37 --70 --70 NNP cord-294218-v4gjabp3 59 38 ° ° NN cord-294218-v4gjabp3 59 39 C C NNP cord-294218-v4gjabp3 59 40 . . . cord-294218-v4gjabp3 60 1 Uninfected uninfected JJ cord-294218-v4gjabp3 60 2 HRT-18 HRT-18 NNP cord-294218-v4gjabp3 60 3 cells cell NNS cord-294218-v4gjabp3 60 4 were be VBD cord-294218-v4gjabp3 60 5 similarly similarly RB cord-294218-v4gjabp3 60 6 radiolabeled radiolabele VBN cord-294218-v4gjabp3 60 7 , , , cord-294218-v4gjabp3 60 8 and and CC cord-294218-v4gjabp3 60 9 mock mock JJ cord-294218-v4gjabp3 60 10 lysates lysate NNS cord-294218-v4gjabp3 60 11 were be VBD cord-294218-v4gjabp3 60 12 prepared prepare VBN cord-294218-v4gjabp3 60 13 as as IN cord-294218-v4gjabp3 60 14 control control NN cord-294218-v4gjabp3 60 15 samples sample NNS cord-294218-v4gjabp3 60 16 . . . cord-294218-v4gjabp3 61 1 The the DT cord-294218-v4gjabp3 61 2 immunoprecipitation immunoprecipitation NN cord-294218-v4gjabp3 61 3 assays assay NNS cord-294218-v4gjabp3 61 4 were be VBD cord-294218-v4gjabp3 61 5 performed perform VBN cord-294218-v4gjabp3 61 6 according accord VBG cord-294218-v4gjabp3 61 7 to to IN cord-294218-v4gjabp3 61 8 Deregt Deregt NNP cord-294218-v4gjabp3 61 9 et et FW cord-294218-v4gjabp3 61 10 al al NNP cord-294218-v4gjabp3 61 11 . . . cord-294218-v4gjabp3 62 1 [ [ -LRB- cord-294218-v4gjabp3 62 2 9 9 CD cord-294218-v4gjabp3 62 3 ] ] -RRB- cord-294218-v4gjabp3 62 4 . . . cord-294218-v4gjabp3 63 1 Briefly briefly RB cord-294218-v4gjabp3 63 2 , , , cord-294218-v4gjabp3 63 3 samples sample NNS cord-294218-v4gjabp3 63 4 of of IN cord-294218-v4gjabp3 63 5 50 50 CD cord-294218-v4gjabp3 63 6 to to TO cord-294218-v4gjabp3 63 7 100 100 CD cord-294218-v4gjabp3 63 8 gl gl NNS cord-294218-v4gjabp3 63 9 of of IN cord-294218-v4gjabp3 63 10 clarified clarify VBN cord-294218-v4gjabp3 63 11 radiolabeled radiolabele VBN cord-294218-v4gjabp3 63 12 cytosol cytosol NN cord-294218-v4gjabp3 63 13 extracts extract NNS cord-294218-v4gjabp3 63 14 ( ( -LRB- cord-294218-v4gjabp3 63 15 1 1 CD cord-294218-v4gjabp3 63 16 × × NN cord-294218-v4gjabp3 63 17 10 10 CD cord-294218-v4gjabp3 63 18 6 6 CD cord-294218-v4gjabp3 63 19 c.p.m c.p.m NNS cord-294218-v4gjabp3 63 20 . . . cord-294218-v4gjabp3 63 21 ) ) -RRB- cord-294218-v4gjabp3 63 22 were be VBD cord-294218-v4gjabp3 63 23 mixed mix VBN cord-294218-v4gjabp3 63 24 with with IN cord-294218-v4gjabp3 63 25 the the DT cord-294218-v4gjabp3 63 26 anti anti JJ cord-294218-v4gjabp3 63 27 - - JJ cord-294218-v4gjabp3 63 28 TCV tcv JJ cord-294218-v4gjabp3 63 29 serum serum NN cord-294218-v4gjabp3 63 30 bound bind VBN cord-294218-v4gjabp3 63 31 to to TO cord-294218-v4gjabp3 63 32 protein protein VB cord-294218-v4gjabp3 63 33 A A NNP cord-294218-v4gjabp3 63 34 - - : cord-294218-v4gjabp3 63 35 Sepharose Sepharose NNP cord-294218-v4gjabp3 63 36 and and CC cord-294218-v4gjabp3 63 37 incubated incubate VBD cord-294218-v4gjabp3 63 38 for for IN cord-294218-v4gjabp3 63 39 2 2 CD cord-294218-v4gjabp3 63 40 h h NN cord-294218-v4gjabp3 63 41 at at IN cord-294218-v4gjabp3 63 42 37 37 CD cord-294218-v4gjabp3 63 43 ° ° NN cord-294218-v4gjabp3 63 44 C C NNP cord-294218-v4gjabp3 63 45 _SP cord-294218-v4gjabp3 63 46 Replicas Replicas NNPS cord-294218-v4gjabp3 63 47 were be VBD cord-294218-v4gjabp3 63 48 prepared prepare VBN cord-294218-v4gjabp3 63 49 by by IN cord-294218-v4gjabp3 63 50 electrophoresis electrophoresis NN cord-294218-v4gjabp3 63 51 transfer transfer NN cord-294218-v4gjabp3 63 52 of of IN cord-294218-v4gjabp3 63 53 proteins protein NNS cord-294218-v4gjabp3 63 54 separated separate VBN cord-294218-v4gjabp3 63 55 by by IN cord-294218-v4gjabp3 63 56 SDS SDS NNP cord-294218-v4gjabp3 63 57 - - HYPH cord-294218-v4gjabp3 63 58 PAGE PAGE NNP cord-294218-v4gjabp3 63 59 to to IN cord-294218-v4gjabp3 63 60 nitrocellulose nitrocellulose NN cord-294218-v4gjabp3 63 61 sheets sheet NNS cord-294218-v4gjabp3 63 62 ( ( -LRB- cord-294218-v4gjabp3 63 63 0.45 0.45 CD cord-294218-v4gjabp3 63 64 ~tm ~tm NNP cord-294218-v4gjabp3 63 65 pore pore NN cord-294218-v4gjabp3 63 66 size size NN cord-294218-v4gjabp3 63 67 , , , cord-294218-v4gjabp3 63 68 Schteicher Schteicher NNP cord-294218-v4gjabp3 63 69 et et NNP cord-294218-v4gjabp3 63 70 Sch Sch NNP cord-294218-v4gjabp3 63 71 / / SYM cord-294218-v4gjabp3 63 72 ill ill NNP cord-294218-v4gjabp3 63 73 ) ) -RRB- cord-294218-v4gjabp3 63 74 as as RB cord-294218-v4gjabp3 63 75 previously previously RB cord-294218-v4gjabp3 63 76 described describe VBN cord-294218-v4gjabp3 63 77 [ [ -LRB- cord-294218-v4gjabp3 63 78 6 6 CD cord-294218-v4gjabp3 63 79 ] ] -RRB- cord-294218-v4gjabp3 63 80 . . . cord-294218-v4gjabp3 64 1 After after IN cord-294218-v4gjabp3 64 2 saturation saturation NN cord-294218-v4gjabp3 64 3 with with IN cord-294218-v4gjabp3 64 4 bovine bovine JJ cord-294218-v4gjabp3 64 5 serum serum NN cord-294218-v4gjabp3 64 6 albumin albumin NN cord-294218-v4gjabp3 64 7 ( ( -LRB- cord-294218-v4gjabp3 64 8 grade grade NN cord-294218-v4gjabp3 64 9 V V NNP cord-294218-v4gjabp3 64 10 ) ) -RRB- cord-294218-v4gjabp3 64 11 , , , cord-294218-v4gjabp3 64 12 the the DT cord-294218-v4gjabp3 64 13 nitrocellulose nitrocellulose NN cord-294218-v4gjabp3 64 14 sheets sheet NNS cord-294218-v4gjabp3 64 15 were be VBD cord-294218-v4gjabp3 64 16 incubated incubate VBN cord-294218-v4gjabp3 64 17 for for IN cord-294218-v4gjabp3 64 18 2 2 CD cord-294218-v4gjabp3 64 19 h h NN cord-294218-v4gjabp3 64 20 at at IN cord-294218-v4gjabp3 64 21 room room NN cord-294218-v4gjabp3 64 22 temperature temperature NN cord-294218-v4gjabp3 64 23 in in IN cord-294218-v4gjabp3 64 24 rabbit rabbit NNP cord-294218-v4gjabp3 64 25 hyperimmune hyperimmune NNP cord-294218-v4gjabp3 64 26 sera sera NNP cord-294218-v4gjabp3 64 27 diluted dilute VBD cord-294218-v4gjabp3 64 28 1:500 1:500 CD cord-294218-v4gjabp3 64 29 in in IN cord-294218-v4gjabp3 64 30 TBS TBS NNP cord-294218-v4gjabp3 64 31 with with IN cord-294218-v4gjabp3 64 32 0.05 0.05 CD cord-294218-v4gjabp3 64 33 % % NN cord-294218-v4gjabp3 64 34 ( ( -LRB- cord-294218-v4gjabp3 64 35 V v NN cord-294218-v4gjabp3 64 36 / / SYM cord-294218-v4gjabp3 64 37 V v NN cord-294218-v4gjabp3 64 38 ) ) -RRB- cord-294218-v4gjabp3 64 39 Tween tween NN cord-294218-v4gjabp3 64 40 20 20 CD cord-294218-v4gjabp3 64 41 ( ( -LRB- cord-294218-v4gjabp3 64 42 TBS TBS NNP cord-294218-v4gjabp3 64 43 - - HYPH cord-294218-v4gjabp3 64 44 T T NNP cord-294218-v4gjabp3 64 45 ) ) -RRB- cord-294218-v4gjabp3 64 46 . . . cord-294218-v4gjabp3 65 1 The the DT cord-294218-v4gjabp3 65 2 nitrocellulose nitrocellulose NN cord-294218-v4gjabp3 65 3 sheets sheet NNS cord-294218-v4gjabp3 65 4 were be VBD cord-294218-v4gjabp3 65 5 subsequently subsequently RB cord-294218-v4gjabp3 65 6 washed wash VBN cord-294218-v4gjabp3 65 7 3 3 CD cord-294218-v4gjabp3 65 8 times time NNS cord-294218-v4gjabp3 65 9 for for IN cord-294218-v4gjabp3 65 10 10 10 CD cord-294218-v4gjabp3 65 11 min min NN cord-294218-v4gjabp3 65 12 in in IN cord-294218-v4gjabp3 65 13 TBS TBS NNP cord-294218-v4gjabp3 65 14 - - HYPH cord-294218-v4gjabp3 65 15 T T NNP cord-294218-v4gjabp3 65 16 , , , cord-294218-v4gjabp3 65 17 and and CC cord-294218-v4gjabp3 65 18 then then RB cord-294218-v4gjabp3 65 19 incubated incubate VBD cord-294218-v4gjabp3 65 20 with with IN cord-294218-v4gjabp3 65 21 1 1 CD cord-294218-v4gjabp3 65 22 : : SYM cord-294218-v4gjabp3 65 23 1000 1000 CD cord-294218-v4gjabp3 65 24 dilution dilution NN cord-294218-v4gjabp3 65 25 of of IN cord-294218-v4gjabp3 65 26 peroxidase peroxidase NN cord-294218-v4gjabp3 65 27 - - HYPH cord-294218-v4gjabp3 65 28 labeled label VBN cord-294218-v4gjabp3 65 29 goat goat NN cord-294218-v4gjabp3 65 30 anti anti JJ cord-294218-v4gjabp3 65 31 - - JJ cord-294218-v4gjabp3 65 32 rabbit rabbit JJ cord-294218-v4gjabp3 65 33 IgG igg NN cord-294218-v4gjabp3 65 34 ( ( -LRB- cord-294218-v4gjabp3 65 35 Boehringer Boehringer NNP cord-294218-v4gjabp3 65 36 - - HYPH cord-294218-v4gjabp3 65 37 Mannheim Mannheim NNP cord-294218-v4gjabp3 65 38 ) ) -RRB- cord-294218-v4gjabp3 65 39 in in IN cord-294218-v4gjabp3 65 40 TBS TBS NNP cord-294218-v4gjabp3 65 41 - - HYPH cord-294218-v4gjabp3 65 42 T T NNP cord-294218-v4gjabp3 65 43 for for IN cord-294218-v4gjabp3 65 44 90 90 CD cord-294218-v4gjabp3 65 45 rain rain NN cord-294218-v4gjabp3 65 46 . . . cord-294218-v4gjabp3 66 1 After after IN cord-294218-v4gjabp3 66 2 washing washing NN cord-294218-v4gjabp3 66 3 , , , cord-294218-v4gjabp3 66 4 blots blot NNS cord-294218-v4gjabp3 66 5 were be VBD cord-294218-v4gjabp3 66 6 developed develop VBN cord-294218-v4gjabp3 66 7 by by IN cord-294218-v4gjabp3 66 8 reaction reaction NN cord-294218-v4gjabp3 66 9 for for IN cord-294218-v4gjabp3 66 10 30 30 CD cord-294218-v4gjabp3 66 11 to to TO cord-294218-v4gjabp3 66 12 45min 45min VB cord-294218-v4gjabp3 66 13 with with IN cord-294218-v4gjabp3 66 14 0.05 0.05 CD cord-294218-v4gjabp3 66 15 % % NN cord-294218-v4gjabp3 66 16 4-chloro 4-chloro CD cord-294218-v4gjabp3 66 17 - - HYPH cord-294218-v4gjabp3 66 18 l l NNP cord-294218-v4gjabp3 66 19 - - HYPH cord-294218-v4gjabp3 66 20 naphthol naphthol NNP cord-294218-v4gjabp3 66 21 ( ( -LRB- cord-294218-v4gjabp3 66 22 Sigma Sigma NNP cord-294218-v4gjabp3 66 23 ) ) -RRB- cord-294218-v4gjabp3 66 24 substrate substrate NN cord-294218-v4gjabp3 66 25 , , , cord-294218-v4gjabp3 66 26 prepared prepare VBN cord-294218-v4gjabp3 66 27 in in IN cord-294218-v4gjabp3 66 28 TBS TBS NNP cord-294218-v4gjabp3 66 29 containing contain VBG cord-294218-v4gjabp3 66 30 20 20 CD cord-294218-v4gjabp3 66 31 % % NN cord-294218-v4gjabp3 66 32 ( ( -LRB- cord-294218-v4gjabp3 66 33 V v NN cord-294218-v4gjabp3 66 34 / / SYM cord-294218-v4gjabp3 66 35 V v NN cord-294218-v4gjabp3 66 36 ) ) -RRB- cord-294218-v4gjabp3 66 37 methanol methanol NN cord-294218-v4gjabp3 66 38 . . . cord-294218-v4gjabp3 67 1 Samples sample NNS cord-294218-v4gjabp3 67 2 were be VBD cord-294218-v4gjabp3 67 3 mixed mix VBN cord-294218-v4gjabp3 67 4 with with IN cord-294218-v4gjabp3 67 5 equal equal JJ cord-294218-v4gjabp3 67 6 volumes volume NNS cord-294218-v4gjabp3 67 7 of of IN cord-294218-v4gjabp3 67 8 double double JJ cord-294218-v4gjabp3 67 9 strength strength NN cord-294218-v4gjabp3 67 10 sample sample NN cord-294218-v4gjabp3 67 11 buffer buffer NN cord-294218-v4gjabp3 67 12 with with IN cord-294218-v4gjabp3 67 13 or or CC cord-294218-v4gjabp3 67 14 without without IN cord-294218-v4gjabp3 67 15 2-mercaptoethanol 2-mercaptoethanol CD cord-294218-v4gjabp3 67 16 , , , cord-294218-v4gjabp3 67 17 boiled boil VBN cord-294218-v4gjabp3 67 18 for for IN cord-294218-v4gjabp3 67 19 3 3 CD cord-294218-v4gjabp3 67 20 min min NN cord-294218-v4gjabp3 67 21 , , , cord-294218-v4gjabp3 67 22 and and CC cord-294218-v4gjabp3 67 23 clarified clarify VBD cord-294218-v4gjabp3 67 24 at at IN cord-294218-v4gjabp3 67 25 10,000 10,000 CD cord-294218-v4gjabp3 67 26 x x SYM cord-294218-v4gjabp3 67 27 g g NN cord-294218-v4gjabp3 67 28 for for IN cord-294218-v4gjabp3 67 29 15 15 CD cord-294218-v4gjabp3 67 30 min min NN cord-294218-v4gjabp3 67 31 before before IN cord-294218-v4gjabp3 67 32 electrophoresis electrophoresis NN cord-294218-v4gjabp3 67 33 in in IN cord-294218-v4gjabp3 67 34 8.5 8.5 CD cord-294218-v4gjabp3 67 35 or or CC cord-294218-v4gjabp3 67 36 10 10 CD cord-294218-v4gjabp3 67 37 percent percent NN cord-294218-v4gjabp3 67 38 SDS sds NN cord-294218-v4gjabp3 67 39 - - HYPH cord-294218-v4gjabp3 67 40 polyacrylamide polyacrylamide NN cord-294218-v4gjabp3 67 41 slab slab NN cord-294218-v4gjabp3 67 42 gels gel NNS cord-294218-v4gjabp3 67 43 , , , cord-294218-v4gjabp3 67 44 as as IN cord-294218-v4gjabp3 67 45 previously previously RB cord-294218-v4gjabp3 67 46 described describe VBN cord-294218-v4gjabp3 67 47 [ [ -LRB- cord-294218-v4gjabp3 67 48 6 6 CD cord-294218-v4gjabp3 67 49 ] ] -RRB- cord-294218-v4gjabp3 67 50 . . . cord-294218-v4gjabp3 68 1 High high JJ cord-294218-v4gjabp3 68 2 and and CC cord-294218-v4gjabp3 68 3 low low JJ cord-294218-v4gjabp3 68 4 molecular molecular JJ cord-294218-v4gjabp3 68 5 weight weight NN cord-294218-v4gjabp3 68 6 marker marker NN cord-294218-v4gjabp3 68 7 proteins protein NNS cord-294218-v4gjabp3 68 8 or or CC cord-294218-v4gjabp3 68 9 14C 14c NN cord-294218-v4gjabp3 68 10 - - HYPH cord-294218-v4gjabp3 68 11 methylated methylated JJ cord-294218-v4gjabp3 68 12 marker marker NN cord-294218-v4gjabp3 68 13 proteins protein NNS cord-294218-v4gjabp3 68 14 were be VBD cord-294218-v4gjabp3 68 15 run run VBN cord-294218-v4gjabp3 68 16 on on IN cord-294218-v4gjabp3 68 17 each each DT cord-294218-v4gjabp3 68 18 gel gel NN cord-294218-v4gjabp3 68 19 to to TO cord-294218-v4gjabp3 68 20 allow allow VB cord-294218-v4gjabp3 68 21 molecular molecular JJ cord-294218-v4gjabp3 68 22 weight weight NN cord-294218-v4gjabp3 68 23 estimates estimate NNS cord-294218-v4gjabp3 68 24 of of IN cord-294218-v4gjabp3 68 25 viral viral JJ cord-294218-v4gjabp3 68 26 proteins protein NNS cord-294218-v4gjabp3 68 27 . . . cord-294218-v4gjabp3 69 1 Gels gel NNS cord-294218-v4gjabp3 69 2 were be VBD cord-294218-v4gjabp3 69 3 analyzed analyze VBN cord-294218-v4gjabp3 69 4 by by IN cord-294218-v4gjabp3 69 5 autoradiography autoradiography NNP cord-294218-v4gjabp3 69 6 or or CC cord-294218-v4gjabp3 69 7 fluorography fluorography NN cord-294218-v4gjabp3 69 8 after after IN cord-294218-v4gjabp3 69 9 " " `` cord-294218-v4gjabp3 69 10 Amplify amplify VB cord-294218-v4gjabp3 69 11 " " '' cord-294218-v4gjabp3 69 12 ( ( -LRB- cord-294218-v4gjabp3 69 13 Amersham Amersham NNP cord-294218-v4gjabp3 69 14 ) ) -RRB- cord-294218-v4gjabp3 69 15 treatment treatment NN cord-294218-v4gjabp3 69 16 . . . cord-294218-v4gjabp3 70 1 Dried dry VBN cord-294218-v4gjabp3 70 2 gels gel NNS cord-294218-v4gjabp3 70 3 were be VBD cord-294218-v4gjabp3 70 4 exposed expose VBN cord-294218-v4gjabp3 70 5 to to IN cord-294218-v4gjabp3 70 6 Kodak Kodak NNP cord-294218-v4gjabp3 70 7 X X NNP cord-294218-v4gjabp3 70 8 - - HYPH cord-294218-v4gjabp3 70 9 OMAT OMAT NNP cord-294218-v4gjabp3 70 10 RP rp NN cord-294218-v4gjabp3 70 11 films film NNS cord-294218-v4gjabp3 70 12 at at IN cord-294218-v4gjabp3 70 13 --70 --70 NNP cord-294218-v4gjabp3 70 14 ° ° NN cord-294218-v4gjabp3 70 15 C C NNP cord-294218-v4gjabp3 70 16 . . . cord-294218-v4gjabp3 71 1 EM EM NNP cord-294218-v4gjabp3 71 2 of of IN cord-294218-v4gjabp3 71 3 infected infected JJ cord-294218-v4gjabp3 71 4 cells cell NNS cord-294218-v4gjabp3 71 5 , , , cord-294218-v4gjabp3 71 6 cultivated cultivate VBN cord-294218-v4gjabp3 71 7 in in IN cord-294218-v4gjabp3 71 8 the the DT cord-294218-v4gjabp3 71 9 presence presence NN cord-294218-v4gjabp3 71 10 of of IN cord-294218-v4gjabp3 71 11 tunicamycin tunicamycin NNS cord-294218-v4gjabp3 71 12 or or CC cord-294218-v4gjabp3 71 13 sodium sodium NN cord-294218-v4gjabp3 71 14 monensin monensin NNP cord-294218-v4gjabp3 71 15 , , , cord-294218-v4gjabp3 71 16 was be VBD cord-294218-v4gjabp3 71 17 done do VBN cord-294218-v4gjabp3 71 18 by by IN cord-294218-v4gjabp3 71 19 fixation fixation NN cord-294218-v4gjabp3 71 20 with with IN cord-294218-v4gjabp3 71 21 2.5 2.5 CD cord-294218-v4gjabp3 71 22 % % NN cord-294218-v4gjabp3 71 23 glutaraldehyde glutaraldehyde NN cord-294218-v4gjabp3 71 24 followed follow VBN cord-294218-v4gjabp3 71 25 by by IN cord-294218-v4gjabp3 71 26 post post JJ cord-294218-v4gjabp3 71 27 - - JJ cord-294218-v4gjabp3 71 28 fixation fixation NN cord-294218-v4gjabp3 71 29 with with IN cord-294218-v4gjabp3 71 30 1 1 CD cord-294218-v4gjabp3 71 31 % % NN cord-294218-v4gjabp3 71 32 osmium osmium NN cord-294218-v4gjabp3 71 33 tetroxide tetroxide NN cord-294218-v4gjabp3 71 34 , , , cord-294218-v4gjabp3 71 35 dehydration dehydration NN cord-294218-v4gjabp3 71 36 in in IN cord-294218-v4gjabp3 71 37 graded grade VBN cord-294218-v4gjabp3 71 38 ethanol ethanol NN cord-294218-v4gjabp3 71 39 and and CC cord-294218-v4gjabp3 71 40 embedding embedding NN cord-294218-v4gjabp3 71 41 in in IN cord-294218-v4gjabp3 71 42 Epoxy Epoxy NNP cord-294218-v4gjabp3 71 43 512 512 CD cord-294218-v4gjabp3 71 44 , , , cord-294218-v4gjabp3 71 45 as as IN cord-294218-v4gjabp3 71 46 previously previously RB cord-294218-v4gjabp3 71 47 described describe VBN cord-294218-v4gjabp3 71 48 [ [ -LRB- cord-294218-v4gjabp3 71 49 7 7 CD cord-294218-v4gjabp3 71 50 ] ] -RRB- cord-294218-v4gjabp3 71 51 . . . cord-294218-v4gjabp3 72 1 Thin thin JJ cord-294218-v4gjabp3 72 2 sections section NNS cord-294218-v4gjabp3 72 3 were be VBD cord-294218-v4gjabp3 72 4 stained stain VBN cord-294218-v4gjabp3 72 5 with with IN cord-294218-v4gjabp3 72 6 lead lead NN cord-294218-v4gjabp3 72 7 - - HYPH cord-294218-v4gjabp3 72 8 citrate citrate NN cord-294218-v4gjabp3 72 9 and and CC cord-294218-v4gjabp3 72 10 uranyl uranyl NN cord-294218-v4gjabp3 72 11 acetate acetate NN cord-294218-v4gjabp3 72 12 [ [ -LRB- cord-294218-v4gjabp3 72 13 11 11 CD cord-294218-v4gjabp3 72 14 ] ] -RRB- cord-294218-v4gjabp3 72 15 and and CC cord-294218-v4gjabp3 72 16 examined examine VBD cord-294218-v4gjabp3 72 17 on on IN cord-294218-v4gjabp3 72 18 a a DT cord-294218-v4gjabp3 72 19 EM EM NNP cord-294218-v4gjabp3 72 20 300 300 CD cord-294218-v4gjabp3 72 21 Philips Philips NNP cord-294218-v4gjabp3 72 22 microscope microscope NN cord-294218-v4gjabp3 72 23 . . . cord-294218-v4gjabp3 73 1 Tunicamycin Tunicamycin NNP cord-294218-v4gjabp3 73 2 ( ( -LRB- cord-294218-v4gjabp3 73 3 TM TM NNP cord-294218-v4gjabp3 73 4 ) ) -RRB- cord-294218-v4gjabp3 73 5 , , , cord-294218-v4gjabp3 73 6 sodium sodium NN cord-294218-v4gjabp3 73 7 monensin monensin NNP cord-294218-v4gjabp3 73 8 ( ( -LRB- cord-294218-v4gjabp3 73 9 SM SM NNP cord-294218-v4gjabp3 73 10 ) ) -RRB- cord-294218-v4gjabp3 73 11 , , , cord-294218-v4gjabp3 73 12 phenylmethylsulfonyl phenylmethylsulfonyl NN cord-294218-v4gjabp3 73 13 fluoride fluoride NN cord-294218-v4gjabp3 73 14 ( ( -LRB- cord-294218-v4gjabp3 73 15 PMSF PMSF NNP cord-294218-v4gjabp3 73 16 ) ) -RRB- cord-294218-v4gjabp3 73 17 , , , cord-294218-v4gjabp3 73 18 aprotinin aprotinin NNP cord-294218-v4gjabp3 73 19 were be VBD cord-294218-v4gjabp3 73 20 purchased purchase VBN cord-294218-v4gjabp3 73 21 from from IN cord-294218-v4gjabp3 73 22 Boehringer Boehringer NNP cord-294218-v4gjabp3 73 23 - - HYPH cord-294218-v4gjabp3 73 24 Mannheim Mannheim NNP cord-294218-v4gjabp3 73 25 Canada Canada NNP cord-294218-v4gjabp3 73 26 Ltd. Ltd. NNP cord-294218-v4gjabp3 73 27 , , , cord-294218-v4gjabp3 73 28 Dorval Dorval NNP cord-294218-v4gjabp3 73 29 , , , cord-294218-v4gjabp3 73 30 Quebec Quebec NNP cord-294218-v4gjabp3 73 31 . . . cord-294218-v4gjabp3 74 1 Stock stock NN cord-294218-v4gjabp3 74 2 solutions solution NNS cord-294218-v4gjabp3 74 3 of of IN cord-294218-v4gjabp3 74 4 TM TM NNP cord-294218-v4gjabp3 74 5 ( ( -LRB- cord-294218-v4gjabp3 74 6 2mg 2mg NNP cord-294218-v4gjabp3 74 7 / / SYM cord-294218-v4gjabp3 74 8 ml ml NN cord-294218-v4gjabp3 74 9 ) ) -RRB- cord-294218-v4gjabp3 74 10 and and CC cord-294218-v4gjabp3 74 11 sodium sodium NN cord-294218-v4gjabp3 74 12 monensin monensin NNP cord-294218-v4gjabp3 74 13 ( ( -LRB- cord-294218-v4gjabp3 74 14 1,000gM 1,000gm CD cord-294218-v4gjabp3 74 15 ) ) -RRB- cord-294218-v4gjabp3 74 16 were be VBD cord-294218-v4gjabp3 74 17 prepared prepare VBN cord-294218-v4gjabp3 74 18 in in IN cord-294218-v4gjabp3 74 19 dimethylsulfoxide dimethylsulfoxide NN cord-294218-v4gjabp3 74 20 and and CC cord-294218-v4gjabp3 74 21 in in IN cord-294218-v4gjabp3 74 22 methanol methanol NN cord-294218-v4gjabp3 74 23 , , , cord-294218-v4gjabp3 74 24 respectively respectively RB cord-294218-v4gjabp3 74 25 . . . cord-294218-v4gjabp3 75 1 These these DT cord-294218-v4gjabp3 75 2 inhibitors inhibitor NNS cord-294218-v4gjabp3 75 3 were be VBD cord-294218-v4gjabp3 75 4 also also RB cord-294218-v4gjabp3 75 5 purchased purchase VBN cord-294218-v4gjabp3 75 6 from from IN cord-294218-v4gjabp3 75 7 Calbiochem Calbiochem NNP cord-294218-v4gjabp3 75 8 , , , cord-294218-v4gjabp3 75 9 La La NNP cord-294218-v4gjabp3 75 10 Jolta Jolta NNP cord-294218-v4gjabp3 75 11 , , , cord-294218-v4gjabp3 75 12 CA CA NNP cord-294218-v4gjabp3 75 13 . . . cord-294218-v4gjabp3 76 1 Bovine bovine JJ cord-294218-v4gjabp3 76 2 pancreatic pancreatic NN cord-294218-v4gjabp3 76 3 trypsin trypsin NN cord-294218-v4gjabp3 76 4 ( ( -LRB- cord-294218-v4gjabp3 76 5 TPCK TPCK NNP cord-294218-v4gjabp3 76 6 treated treat VBN cord-294218-v4gjabp3 76 7 , , , cord-294218-v4gjabp3 76 8 12,300 12,300 CD cord-294218-v4gjabp3 76 9 units unit NNS cord-294218-v4gjabp3 76 10 / / SYM cord-294218-v4gjabp3 76 11 mg mg NNP cord-294218-v4gjabp3 76 12 ) ) -RRB- cord-294218-v4gjabp3 76 13 and and CC cord-294218-v4gjabp3 76 14 4chloro 4chloro CD cord-294218-v4gjabp3 76 15 - - HYPH cord-294218-v4gjabp3 76 16 l l NN cord-294218-v4gjabp3 76 17 - - HYPH cord-294218-v4gjabp3 76 18 naphthol naphthol NNP cord-294218-v4gjabp3 76 19 were be VBD cord-294218-v4gjabp3 76 20 purchased purchase VBN cord-294218-v4gjabp3 76 21 from from IN cord-294218-v4gjabp3 76 22 Sigma Sigma NNP cord-294218-v4gjabp3 76 23 Chemical Chemical NNP cord-294218-v4gjabp3 76 24 Co Co NNP cord-294218-v4gjabp3 76 25 , , , cord-294218-v4gjabp3 76 26 St. St. NNP cord-294218-v4gjabp3 76 27 Louis Louis NNP cord-294218-v4gjabp3 76 28 , , , cord-294218-v4gjabp3 76 29 MO MO NNP cord-294218-v4gjabp3 76 30 . . . cord-294218-v4gjabp3 77 1 Reagents reagent NNS cord-294218-v4gjabp3 77 2 for for IN cord-294218-v4gjabp3 77 3 SDS SDS NNP cord-294218-v4gjabp3 77 4 - - HYPH cord-294218-v4gjabp3 77 5 PAGE PAGE NNP cord-294218-v4gjabp3 77 6 were be VBD cord-294218-v4gjabp3 77 7 purchased purchase VBN cord-294218-v4gjabp3 77 8 from from IN cord-294218-v4gjabp3 77 9 BIO BIO NNP cord-294218-v4gjabp3 77 10 - - HYPH cord-294218-v4gjabp3 77 11 RAD RAD NNP cord-294218-v4gjabp3 77 12 Laboratories Laboratories NNP cord-294218-v4gjabp3 77 13 , , , cord-294218-v4gjabp3 77 14 Richmond Richmond NNP cord-294218-v4gjabp3 77 15 , , , cord-294218-v4gjabp3 77 16 CA CA NNP cord-294218-v4gjabp3 77 17 . . . cord-294218-v4gjabp3 78 1 Protein Protein NNP cord-294218-v4gjabp3 78 2 A a DT cord-294218-v4gjabp3 78 3 Sepharose Sepharose NNP cord-294218-v4gjabp3 78 4 CL-4B CL-4B NNP cord-294218-v4gjabp3 78 5 and and CC cord-294218-v4gjabp3 78 6 molecular molecular JJ cord-294218-v4gjabp3 78 7 weight weight NN cord-294218-v4gjabp3 78 8 marker marker NN cord-294218-v4gjabp3 78 9 proteins protein NNS cord-294218-v4gjabp3 78 10 were be VBD cord-294218-v4gjabp3 78 11 purchased purchase VBN cord-294218-v4gjabp3 78 12 from from IN cord-294218-v4gjabp3 78 13 Pharmacia Pharmacia NNP cord-294218-v4gjabp3 78 14 , , , cord-294218-v4gjabp3 78 15 Uppsala Uppsala NNP cord-294218-v4gjabp3 78 16 , , , cord-294218-v4gjabp3 78 17 Sweden Sweden NNP cord-294218-v4gjabp3 78 18 . . . cord-294218-v4gjabp3 79 1 L-[35S]methionine L-[35S]methionine NNP cord-294218-v4gjabp3 79 2 ( ( -LRB- cord-294218-v4gjabp3 79 3 1,120 1,120 CD cord-294218-v4gjabp3 79 4 Ci Ci NNP cord-294218-v4gjabp3 79 5 / / SYM cord-294218-v4gjabp3 79 6 mmole mmole NNP cord-294218-v4gjabp3 79 7 ) ) -RRB- cord-294218-v4gjabp3 79 8 and and CC cord-294218-v4gjabp3 79 9 a a DT cord-294218-v4gjabp3 79 10 mixture mixture NN cord-294218-v4gjabp3 79 11 of of IN cord-294218-v4gjabp3 79 12 14C 14c NN cord-294218-v4gjabp3 79 13 - - HYPH cord-294218-v4gjabp3 79 14 methylated methylated JJ cord-294218-v4gjabp3 79 15 marker marker NN cord-294218-v4gjabp3 79 16 proteins protein NNS cord-294218-v4gjabp3 79 17 were be VBD cord-294218-v4gjabp3 79 18 purchasesd purchasesd NNS cord-294218-v4gjabp3 79 19 from from IN cord-294218-v4gjabp3 79 20 Amersham Amersham NNP cord-294218-v4gjabp3 79 21 Searle Searle NNP cord-294218-v4gjabp3 79 22 Co. Co. NNP cord-294218-v4gjabp3 79 23 , , , cord-294218-v4gjabp3 79 24 Oakville Oakville NNP cord-294218-v4gjabp3 79 25 , , , cord-294218-v4gjabp3 79 26 Ontario Ontario NNP cord-294218-v4gjabp3 79 27 . . . cord-294218-v4gjabp3 80 1 D-[6 d-[6 JJ cord-294218-v4gjabp3 80 2 - - JJ cord-294218-v4gjabp3 80 3 3H]glucosamine 3h]glucosamine CD cord-294218-v4gjabp3 80 4 hydrochloride hydrochloride NN cord-294218-v4gjabp3 80 5 ( ( -LRB- cord-294218-v4gjabp3 80 6 2%20 2%20 NNP cord-294218-v4gjabp3 80 7 Ci Ci NNP cord-294218-v4gjabp3 80 8 / / SYM cord-294218-v4gjabp3 80 9 mmole mmole NNP cord-294218-v4gjabp3 80 10 ) ) -RRB- cord-294218-v4gjabp3 80 11 was be VBD cord-294218-v4gjabp3 80 12 purchased purchase VBN cord-294218-v4gjabp3 80 13 from from IN cord-294218-v4gjabp3 80 14 ICN ICN NNP cord-294218-v4gjabp3 80 15 Biochemical Biochemical NNP cord-294218-v4gjabp3 80 16 Canada Canada NNP cord-294218-v4gjabp3 80 17 Ltd Ltd NNP cord-294218-v4gjabp3 80 18 , , , cord-294218-v4gjabp3 80 19 Montreal Montreal NNP cord-294218-v4gjabp3 80 20 , , , cord-294218-v4gjabp3 80 21 Quebec Quebec NNP cord-294218-v4gjabp3 80 22 . . . cord-294218-v4gjabp3 81 1 Pulse pulse NN cord-294218-v4gjabp3 81 2 labeling labeling NN cord-294218-v4gjabp3 81 3 of of IN cord-294218-v4gjabp3 81 4 cells cell NNS cord-294218-v4gjabp3 81 5 with with IN cord-294218-v4gjabp3 81 6 [ [ -LRB- cord-294218-v4gjabp3 81 7 35S]methionine 35s]methionine CD cord-294218-v4gjabp3 81 8 at at IN cord-294218-v4gjabp3 81 9 different different JJ cord-294218-v4gjabp3 81 10 times time NNS cord-294218-v4gjabp3 81 11 after after IN cord-294218-v4gjabp3 81 12 infection infection NN cord-294218-v4gjabp3 81 13 , , , cord-294218-v4gjabp3 81 14 followed follow VBN cord-294218-v4gjabp3 81 15 by by IN cord-294218-v4gjabp3 81 16 S s NN cord-294218-v4gjabp3 81 17 D D NNP cord-294218-v4gjabp3 81 18 S s NN cord-294218-v4gjabp3 82 1 -P -P . cord-294218-v4gjabp3 83 1 A a DT cord-294218-v4gjabp3 83 2 G g NN cord-294218-v4gjabp3 83 3 E e NN cord-294218-v4gjabp3 83 4 was be VBD cord-294218-v4gjabp3 83 5 used use VBN cord-294218-v4gjabp3 83 6 to to TO cord-294218-v4gjabp3 83 7 resolve resolve VB cord-294218-v4gjabp3 83 8 and and CC cord-294218-v4gjabp3 83 9 to to TO cord-294218-v4gjabp3 83 10 identify identify VB cord-294218-v4gjabp3 83 11 polypeptides polypeptide NNS cord-294218-v4gjabp3 83 12 designated designate VBN cord-294218-v4gjabp3 83 13 as as IN cord-294218-v4gjabp3 83 14 specific specific JJ cord-294218-v4gjabp3 83 15 to to IN cord-294218-v4gjabp3 83 16 TCV TCV NNP cord-294218-v4gjabp3 83 17 - - HYPH cord-294218-v4gjabp3 83 18 infected infect VBN cord-294218-v4gjabp3 83 19 HRT-18 HRT-18 NNP cord-294218-v4gjabp3 83 20 cell cell NN cord-294218-v4gjabp3 83 21 cultures culture NNS cord-294218-v4gjabp3 83 22 ( ( -LRB- cord-294218-v4gjabp3 83 23 Fig Fig NNP cord-294218-v4gjabp3 83 24 . . . cord-294218-v4gjabp3 83 25 1A 1a NN cord-294218-v4gjabp3 83 26 ) ) -RRB- cord-294218-v4gjabp3 83 27 . . . cord-294218-v4gjabp3 84 1 Late late RB cord-294218-v4gjabp3 84 2 in in IN cord-294218-v4gjabp3 84 3 infection infection NN cord-294218-v4gjabp3 84 4 , , , cord-294218-v4gjabp3 84 5 it -PRON- PRP cord-294218-v4gjabp3 84 6 was be VBD cord-294218-v4gjabp3 84 7 possible possible JJ cord-294218-v4gjabp3 84 8 to to TO cord-294218-v4gjabp3 84 9 detect detect VB cord-294218-v4gjabp3 84 10 the the DT cord-294218-v4gjabp3 84 11 synthesis synthesis NN cord-294218-v4gjabp3 84 12 of of IN cord-294218-v4gjabp3 84 13 four four CD cord-294218-v4gjabp3 84 14 major major JJ cord-294218-v4gjabp3 84 15 TCV TCV NNP cord-294218-v4gjabp3 84 16 - - HYPH cord-294218-v4gjabp3 84 17 induced induce VBN cord-294218-v4gjabp3 84 18 polypeptides polypeptide NNS cord-294218-v4gjabp3 84 19 with with IN cord-294218-v4gjabp3 84 20 apparent apparent JJ cord-294218-v4gjabp3 84 21 mol.wt mol.wt NNP cord-294218-v4gjabp3 84 22 , , , cord-294218-v4gjabp3 84 23 of of IN cord-294218-v4gjabp3 84 24 140,000 140,000 CD cord-294218-v4gjabp3 84 25 , , , cord-294218-v4gjabp3 84 26 100,000 100,000 CD cord-294218-v4gjabp3 84 27 , , , cord-294218-v4gjabp3 84 28 52,000 52,000 CD cord-294218-v4gjabp3 84 29 , , , cord-294218-v4gjabp3 84 30 and and CC cord-294218-v4gjabp3 84 31 24,000 24,000 CD cord-294218-v4gjabp3 84 32 which which WDT cord-294218-v4gjabp3 84 33 were be VBD cord-294218-v4gjabp3 84 34 not not RB cord-294218-v4gjabp3 84 35 present present JJ cord-294218-v4gjabp3 84 36 in in IN cord-294218-v4gjabp3 84 37 mock mock JJ cord-294218-v4gjabp3 84 38 - - HYPH cord-294218-v4gjabp3 84 39 infected infect VBN cord-294218-v4gjabp3 84 40 control control NN cord-294218-v4gjabp3 84 41 cultures culture NNS cord-294218-v4gjabp3 84 42 ( ( -LRB- cord-294218-v4gjabp3 84 43 lane lane NNP cord-294218-v4gjabp3 84 44 M M NNP cord-294218-v4gjabp3 84 45 ) ) -RRB- cord-294218-v4gjabp3 84 46 . . . cord-294218-v4gjabp3 85 1 Up up IN cord-294218-v4gjabp3 85 2 to to TO cord-294218-v4gjabp3 85 3 four four CD cord-294218-v4gjabp3 85 4 or or CC cord-294218-v4gjabp3 85 5 five five CD cord-294218-v4gjabp3 85 6 minor minor JJ cord-294218-v4gjabp3 85 7 polypeptides polypeptide NNS cord-294218-v4gjabp3 85 8 were be VBD cord-294218-v4gjabp3 85 9 also also RB cord-294218-v4gjabp3 85 10 consistently consistently RB cord-294218-v4gjabp3 85 11 resolved resolve VBN cord-294218-v4gjabp3 85 12 and and CC cord-294218-v4gjabp3 85 13 migrated migrate VBN cord-294218-v4gjabp3 85 14 with with IN cord-294218-v4gjabp3 85 15 estimated estimate VBN cord-294218-v4gjabp3 85 16 mol.wt mol.wt NNP cord-294218-v4gjabp3 85 17 , , , cord-294218-v4gjabp3 85 18 of of IN cord-294218-v4gjabp3 85 19 200,000 200,000 CD cord-294218-v4gjabp3 85 20 , , , cord-294218-v4gjabp3 85 21 170,000 170,000 CD cord-294218-v4gjabp3 85 22 , , , cord-294218-v4gjabp3 85 23 36 36 CD cord-294218-v4gjabp3 85 24 - - SYM cord-294218-v4gjabp3 85 25 38,000 38,000 CD cord-294218-v4gjabp3 85 26 , , , cord-294218-v4gjabp3 85 27 and and CC cord-294218-v4gjabp3 85 28 30 30 CD cord-294218-v4gjabp3 85 29 - - SYM cord-294218-v4gjabp3 85 30 32,000 32,000 CD cord-294218-v4gjabp3 85 31 , , , cord-294218-v4gjabp3 85 32 respectively respectively RB cord-294218-v4gjabp3 86 1 ( ( -LRB- cord-294218-v4gjabp3 86 2 Fig Fig NNP cord-294218-v4gjabp3 86 3 . . . cord-294218-v4gjabp3 86 4 1A 1a NN cord-294218-v4gjabp3 86 5 , , , cord-294218-v4gjabp3 86 6 arrowheads arrowhead NNS cord-294218-v4gjabp3 86 7 ) ) -RRB- cord-294218-v4gjabp3 86 8 . . . cord-294218-v4gjabp3 87 1 The the DT cord-294218-v4gjabp3 87 2 170,000 170,000 CD cord-294218-v4gjabp3 87 3 minor minor JJ cord-294218-v4gjabp3 87 4 polypeptide polypeptide NN cord-294218-v4gjabp3 87 5 was be VBD cord-294218-v4gjabp3 87 6 reproducibly reproducibly RB cord-294218-v4gjabp3 87 7 resolved resolve VBN cord-294218-v4gjabp3 87 8 as as IN cord-294218-v4gjabp3 87 9 a a DT cord-294218-v4gjabp3 87 10 doublet doublet NN cord-294218-v4gjabp3 87 11 . . . cord-294218-v4gjabp3 88 1 The the DT cord-294218-v4gjabp3 88 2 predominant predominant JJ cord-294218-v4gjabp3 88 3 52,000 52,000 CD cord-294218-v4gjabp3 88 4 nucleoprotein nucleoprotein NNP cord-294218-v4gjabp3 88 5 could could MD cord-294218-v4gjabp3 88 6 be be VB cord-294218-v4gjabp3 88 7 detected detect VBN cord-294218-v4gjabp3 88 8 as as RB cord-294218-v4gjabp3 88 9 soon soon RB cord-294218-v4gjabp3 88 10 as as IN cord-294218-v4gjabp3 88 11 6 6 CD cord-294218-v4gjabp3 88 12 to to TO cord-294218-v4gjabp3 88 13 8 8 CD cord-294218-v4gjabp3 88 14 hours hour NNS cord-294218-v4gjabp3 88 15 post post NN cord-294218-v4gjabp3 88 16 - - NN cord-294218-v4gjabp3 88 17 infection infection NN cord-294218-v4gjabp3 88 18 and and CC cord-294218-v4gjabp3 88 19 was be VBD cord-294218-v4gjabp3 88 20 initially initially RB cord-294218-v4gjabp3 88 21 resolved resolve VBN cord-294218-v4gjabp3 88 22 as as IN cord-294218-v4gjabp3 88 23 a a DT cord-294218-v4gjabp3 88 24 group group NN cord-294218-v4gjabp3 88 25 of of IN cord-294218-v4gjabp3 88 26 3 3 CD cord-294218-v4gjabp3 88 27 closely closely RB cord-294218-v4gjabp3 88 28 migrating migrate VBG cord-294218-v4gjabp3 88 29 bands band NNS cord-294218-v4gjabp3 88 30 ; ; : cord-294218-v4gjabp3 88 31 the the DT cord-294218-v4gjabp3 88 32 two two CD cord-294218-v4gjabp3 88 33 other other JJ cord-294218-v4gjabp3 88 34 polypeptides polypeptide NNS cord-294218-v4gjabp3 88 35 migrated migrate VBN cord-294218-v4gjabp3 88 36 with with IN cord-294218-v4gjabp3 88 37 estimated estimate VBN cord-294218-v4gjabp3 88 38 mol.wt mol.wt NNP cord-294218-v4gjabp3 88 39 , , , cord-294218-v4gjabp3 88 40 of of IN cord-294218-v4gjabp3 88 41 46,000 46,000 CD cord-294218-v4gjabp3 88 42 and and CC cord-294218-v4gjabp3 88 43 48,000 48,000 CD cord-294218-v4gjabp3 88 44 , , , cord-294218-v4gjabp3 88 45 respectively respectively RB cord-294218-v4gjabp3 88 46 . . . cord-294218-v4gjabp3 89 1 By by IN cord-294218-v4gjabp3 89 2 12 12 CD cord-294218-v4gjabp3 89 3 hours hour NNS cord-294218-v4gjabp3 89 4 , , , cord-294218-v4gjabp3 89 5 all all DT cord-294218-v4gjabp3 89 6 four four CD cord-294218-v4gjabp3 89 7 major major JJ cord-294218-v4gjabp3 89 8 TCVinduced tcvinduce VBN cord-294218-v4gjabp3 89 9 polypeptides polypeptide NNS cord-294218-v4gjabp3 89 10 were be VBD cord-294218-v4gjabp3 89 11 present present JJ cord-294218-v4gjabp3 89 12 ; ; : cord-294218-v4gjabp3 89 13 they -PRON- PRP cord-294218-v4gjabp3 89 14 persisted persist VBD cord-294218-v4gjabp3 89 15 until until IN cord-294218-v4gjabp3 89 16 virus virus NN cord-294218-v4gjabp3 89 17 and and CC cord-294218-v4gjabp3 89 18 host host NN cord-294218-v4gjabp3 89 19 cell cell NN cord-294218-v4gjabp3 89 20 protein protein NN cord-294218-v4gjabp3 89 21 synthesis synthesis NN cord-294218-v4gjabp3 89 22 was be VBD cord-294218-v4gjabp3 89 23 reduced reduce VBN cord-294218-v4gjabp3 89 24 due due IN cord-294218-v4gjabp3 89 25 to to IN cord-294218-v4gjabp3 89 26 extensive extensive JJ cord-294218-v4gjabp3 89 27 cytopathic cytopathic JJ cord-294218-v4gjabp3 89 28 changes change NNS cord-294218-v4gjabp3 89 29 ( ( -LRB- cord-294218-v4gjabp3 89 30 between between IN cord-294218-v4gjabp3 89 31 48 48 CD cord-294218-v4gjabp3 89 32 and and CC cord-294218-v4gjabp3 89 33 72 72 CD cord-294218-v4gjabp3 89 34 hours hour NNS cord-294218-v4gjabp3 89 35 post post NN cord-294218-v4gjabp3 89 36 - - NN cord-294218-v4gjabp3 89 37 infection infection JJ cord-294218-v4gjabp3 89 38 ) ) -RRB- cord-294218-v4gjabp3 89 39 . . . cord-294218-v4gjabp3 90 1 Between between IN cord-294218-v4gjabp3 90 2 12 12 CD cord-294218-v4gjabp3 90 3 and and CC cord-294218-v4gjabp3 90 4 24 24 CD cord-294218-v4gjabp3 90 5 hours hour NNS cord-294218-v4gjabp3 90 6 , , , cord-294218-v4gjabp3 90 7 all all DT cord-294218-v4gjabp3 90 8 polypeptides polypeptide NNS cord-294218-v4gjabp3 90 9 appeared appear VBD cord-294218-v4gjabp3 90 10 to to TO cord-294218-v4gjabp3 90 11 be be VB cord-294218-v4gjabp3 90 12 synthesized synthesize VBN cord-294218-v4gjabp3 90 13 at at IN cord-294218-v4gjabp3 90 14 a a DT cord-294218-v4gjabp3 90 15 relatively relatively RB cord-294218-v4gjabp3 90 16 constant constant JJ cord-294218-v4gjabp3 90 17 rate rate NN cord-294218-v4gjabp3 90 18 , , , cord-294218-v4gjabp3 90 19 without without IN cord-294218-v4gjabp3 90 20 any any DT cord-294218-v4gjabp3 90 21 apparent apparent JJ cord-294218-v4gjabp3 90 22 shut shut NN cord-294218-v4gjabp3 90 23 - - HYPH cord-294218-v4gjabp3 90 24 off off NN cord-294218-v4gjabp3 90 25 of of IN cord-294218-v4gjabp3 90 26 host host NN cord-294218-v4gjabp3 90 27 cell cell NN cord-294218-v4gjabp3 90 28 protein protein NN cord-294218-v4gjabp3 90 29 synthesis synthesis NN cord-294218-v4gjabp3 90 30 . . . cord-294218-v4gjabp3 91 1 The the DT cord-294218-v4gjabp3 91 2 four four CD cord-294218-v4gjabp3 91 3 major major JJ cord-294218-v4gjabp3 91 4 intracellular intracellular JJ cord-294218-v4gjabp3 91 5 polypeptide polypeptide NN cord-294218-v4gjabp3 91 6 species specie NNS cord-294218-v4gjabp3 91 7 comigrated comigrate VBN cord-294218-v4gjabp3 91 8 with with IN cord-294218-v4gjabp3 91 9 the the DT cord-294218-v4gjabp3 91 10 viral viral JJ cord-294218-v4gjabp3 91 11 polypeptides polypeptide NNS cord-294218-v4gjabp3 91 12 ( ( -LRB- cord-294218-v4gjabp3 91 13 lane lane NN cord-294218-v4gjabp3 91 14 V V NNP cord-294218-v4gjabp3 91 15 ) ) -RRB- cord-294218-v4gjabp3 91 16 , , , cord-294218-v4gjabp3 91 17 as as RB cord-294218-v4gjabp3 91 18 well well RB cord-294218-v4gjabp3 91 19 as as IN cord-294218-v4gjabp3 91 20 the the DT cord-294218-v4gjabp3 91 21 200,000 200,000 CD cord-294218-v4gjabp3 91 22 and and CC cord-294218-v4gjabp3 91 23 the the DT cord-294218-v4gjabp3 91 24 36 36 CD cord-294218-v4gjabp3 91 25 - - SYM cord-294218-v4gjabp3 91 26 38,000 38,000 CD cord-294218-v4gjabp3 91 27 polypeptide polypeptide NN cord-294218-v4gjabp3 91 28 species specie NNS cord-294218-v4gjabp3 91 29 . . . cord-294218-v4gjabp3 92 1 The the DT cord-294218-v4gjabp3 92 2 latter latter JJ cord-294218-v4gjabp3 92 3 co co VBD cord-294218-v4gjabp3 92 4 - - VBD cord-294218-v4gjabp3 92 5 migrated migrate VBN cord-294218-v4gjabp3 92 6 also also RB cord-294218-v4gjabp3 92 7 with with IN cord-294218-v4gjabp3 92 8 a a DT cord-294218-v4gjabp3 92 9 polypeptide polypeptide NN cord-294218-v4gjabp3 92 10 having have VBG cord-294218-v4gjabp3 92 11 similar similar JJ cord-294218-v4gjabp3 92 12 mol.wt mol.wt NNP cord-294218-v4gjabp3 92 13 , , , cord-294218-v4gjabp3 92 14 which which WDT cord-294218-v4gjabp3 92 15 also also RB cord-294218-v4gjabp3 92 16 was be VBD cord-294218-v4gjabp3 92 17 present present JJ cord-294218-v4gjabp3 92 18 in in IN cord-294218-v4gjabp3 92 19 mock mock JJ cord-294218-v4gjabp3 92 20 - - HYPH cord-294218-v4gjabp3 92 21 infected infect VBN cord-294218-v4gjabp3 92 22 cells cell NNS cord-294218-v4gjabp3 92 23 . . . cord-294218-v4gjabp3 93 1 All all PDT cord-294218-v4gjabp3 93 2 these these DT cord-294218-v4gjabp3 93 3 polypeptides polypeptide NNS cord-294218-v4gjabp3 93 4 , , , cord-294218-v4gjabp3 93 5 as as RB cord-294218-v4gjabp3 93 6 well well RB cord-294218-v4gjabp3 93 7 as as IN cord-294218-v4gjabp3 93 8 the the DT cord-294218-v4gjabp3 93 9 2 2 CD cord-294218-v4gjabp3 93 10 species specie NNS cord-294218-v4gjabp3 93 11 that that WDT cord-294218-v4gjabp3 93 12 closely closely RB cord-294218-v4gjabp3 93 13 migrated migrate VBD cord-294218-v4gjabp3 93 14 with with IN cord-294218-v4gjabp3 93 15 the the DT cord-294218-v4gjabp3 93 16 nucleocapsid nucleocapsid NNP cord-294218-v4gjabp3 93 17 protein protein NN cord-294218-v4gjabp3 93 18 , , , cord-294218-v4gjabp3 93 19 were be VBD cord-294218-v4gjabp3 93 20 revealed reveal VBN cord-294218-v4gjabp3 93 21 by by IN cord-294218-v4gjabp3 93 22 Western Western NNP cord-294218-v4gjabp3 93 23 - - HYPH cord-294218-v4gjabp3 93 24 immunoblotting immunoblotte VBG cord-294218-v4gjabp3 93 25 using use VBG cord-294218-v4gjabp3 93 26 the the DT cord-294218-v4gjabp3 93 27 anti anti JJ cord-294218-v4gjabp3 93 28 - - JJ cord-294218-v4gjabp3 93 29 TCV tcv JJ cord-294218-v4gjabp3 93 30 rabbit rabbit NN cord-294218-v4gjabp3 93 31 hyperimmune hyperimmune NNP cord-294218-v4gjabp3 93 32 serum serum NN cord-294218-v4gjabp3 93 33 ( ( -LRB- cord-294218-v4gjabp3 93 34 Fig Fig NNP cord-294218-v4gjabp3 93 35 . . . cord-294218-v4gjabp3 93 36 1 1 CD cord-294218-v4gjabp3 93 37 C C NNP cord-294218-v4gjabp3 93 38 ) ) -RRB- cord-294218-v4gjabp3 93 39 . . . cord-294218-v4gjabp3 94 1 The the DT cord-294218-v4gjabp3 94 2 30 30 CD cord-294218-v4gjabp3 94 3 - - SYM cord-294218-v4gjabp3 94 4 32,000 32,000 CD cord-294218-v4gjabp3 94 5 polypeptide polypeptide NN cord-294218-v4gjabp3 94 6 was be VBD cord-294218-v4gjabp3 94 7 not not RB cord-294218-v4gjabp3 94 8 revealed reveal VBN cord-294218-v4gjabp3 94 9 by by IN cord-294218-v4gjabp3 94 10 the the DT cord-294218-v4gjabp3 94 11 antiserum antiserum NN cord-294218-v4gjabp3 94 12 and and CC cord-294218-v4gjabp3 94 13 may may MD cord-294218-v4gjabp3 94 14 represent represent VB cord-294218-v4gjabp3 94 15 a a DT cord-294218-v4gjabp3 94 16 non non JJ cord-294218-v4gjabp3 94 17 - - JJ cord-294218-v4gjabp3 94 18 structural structural JJ cord-294218-v4gjabp3 94 19 polypeptide polypeptide NN cord-294218-v4gjabp3 94 20 . . . cord-294218-v4gjabp3 95 1 Under under IN cord-294218-v4gjabp3 95 2 reducing reduce VBG cord-294218-v4gjabp3 95 3 conditions condition NNS cord-294218-v4gjabp3 95 4 ( ( -LRB- cord-294218-v4gjabp3 95 5 Fig fig NN cord-294218-v4gjabp3 95 6 . . . cord-294218-v4gjabp3 95 7 1 1 CD cord-294218-v4gjabp3 95 8 B b NN cord-294218-v4gjabp3 95 9 ) ) -RRB- cord-294218-v4gjabp3 95 10 , , , cord-294218-v4gjabp3 95 11 the the DT cord-294218-v4gjabp3 95 12 major major JJ cord-294218-v4gjabp3 95 13 140,000 140,000 CD cord-294218-v4gjabp3 95 14 intracellular intracellular JJ cord-294218-v4gjabp3 95 15 polypeptide polypeptide NN cord-294218-v4gjabp3 95 16 was be VBD cord-294218-v4gjabp3 95 17 not not RB cord-294218-v4gjabp3 95 18 present present JJ cord-294218-v4gjabp3 95 19 , , , cord-294218-v4gjabp3 95 20 but but CC cord-294218-v4gjabp3 95 21 replaced replace VBN cord-294218-v4gjabp3 95 22 by by IN cord-294218-v4gjabp3 95 23 another another DT cord-294218-v4gjabp3 95 24 major major JJ cord-294218-v4gjabp3 95 25 component component NN cord-294218-v4gjabp3 95 26 with with IN cord-294218-v4gjabp3 95 27 mol.wt mol.wt NNP cord-294218-v4gjabp3 95 28 . . . cord-294218-v4gjabp3 96 1 of of IN cord-294218-v4gjabp3 96 2 approximately approximately RB cord-294218-v4gjabp3 96 3 60 60 CD cord-294218-v4gjabp3 96 4 - - SYM cord-294218-v4gjabp3 96 5 65,000 65,000 CD cord-294218-v4gjabp3 96 6 . . . cord-294218-v4gjabp3 97 1 The the DT cord-294218-v4gjabp3 97 2 intracellular intracellular JJ cord-294218-v4gjabp3 97 3 polypeptide polypeptide NN cord-294218-v4gjabp3 97 4 corresponding correspond VBG cord-294218-v4gjabp3 97 5 to to IN cord-294218-v4gjabp3 97 6 the the DT cord-294218-v4gjabp3 97 7 viral viral JJ cord-294218-v4gjabp3 97 8 matrix matrix NN cord-294218-v4gjabp3 97 9 protein protein NN cord-294218-v4gjabp3 97 10 was be VBD cord-294218-v4gjabp3 97 11 usually usually RB cord-294218-v4gjabp3 97 12 resolved resolve VBN cord-294218-v4gjabp3 97 13 as as IN cord-294218-v4gjabp3 97 14 a a DT cord-294218-v4gjabp3 97 15 doublet doublet NN cord-294218-v4gjabp3 97 16 ( ( -LRB- cord-294218-v4gjabp3 97 17 22,000 22,000 CD cord-294218-v4gjabp3 97 18 and and CC cord-294218-v4gjabp3 97 19 24,000 24,000 CD cord-294218-v4gjabp3 97 20 ) ) -RRB- cord-294218-v4gjabp3 97 21 . . . cord-294218-v4gjabp3 98 1 To to TO cord-294218-v4gjabp3 98 2 investigate investigate VB cord-294218-v4gjabp3 98 3 the the DT cord-294218-v4gjabp3 98 4 intracellular intracellular JJ cord-294218-v4gjabp3 98 5 processing processing NN cord-294218-v4gjabp3 98 6 of of IN cord-294218-v4gjabp3 98 7 the the DT cord-294218-v4gjabp3 98 8 viral viral JJ cord-294218-v4gjabp3 98 9 structural structural JJ cord-294218-v4gjabp3 98 10 proteins protein NNS cord-294218-v4gjabp3 98 11 , , , cord-294218-v4gjabp3 98 12 TCVinfected tcvinfected JJ cord-294218-v4gjabp3 98 13 and and CC cord-294218-v4gjabp3 98 14 mock mock JJ cord-294218-v4gjabp3 98 15 - - HYPH cord-294218-v4gjabp3 98 16 infected infect VBN cord-294218-v4gjabp3 98 17 HRT-18 HRT-18 NNP cord-294218-v4gjabp3 98 18 cells cell NNS cord-294218-v4gjabp3 98 19 were be VBD cord-294218-v4gjabp3 98 20 pulse pulse NN cord-294218-v4gjabp3 98 21 - - HYPH cord-294218-v4gjabp3 98 22 labeled label VBN cord-294218-v4gjabp3 98 23 from from IN cord-294218-v4gjabp3 98 24 6 6 CD cord-294218-v4gjabp3 98 25 to to TO cord-294218-v4gjabp3 98 26 12 12 CD cord-294218-v4gjabp3 98 27 hours hour NNS cord-294218-v4gjabp3 98 28 after after IN cord-294218-v4gjabp3 98 29 infection infection NN cord-294218-v4gjabp3 98 30 for for IN cord-294218-v4gjabp3 98 31 30 30 CD cord-294218-v4gjabp3 98 32 min min NN cord-294218-v4gjabp3 98 33 with with IN cord-294218-v4gjabp3 98 34 [ [ -LRB- cord-294218-v4gjabp3 98 35 35S]methionine 35s]methionine CD cord-294218-v4gjabp3 98 36 , , , cord-294218-v4gjabp3 98 37 and and CC cord-294218-v4gjabp3 98 38 the the DT cord-294218-v4gjabp3 98 39 label label NN cord-294218-v4gjabp3 98 40 was be VBD cord-294218-v4gjabp3 98 41 chased chase VBN cord-294218-v4gjabp3 98 42 for for IN cord-294218-v4gjabp3 98 43 various various JJ cord-294218-v4gjabp3 98 44 times time NNS cord-294218-v4gjabp3 98 45 . . . cord-294218-v4gjabp3 99 1 Polypeptides polypeptide NNS cord-294218-v4gjabp3 99 2 specific specific JJ cord-294218-v4gjabp3 99 3 to to IN cord-294218-v4gjabp3 99 4 TCV TCV NNP cord-294218-v4gjabp3 99 5 - - HYPH cord-294218-v4gjabp3 99 6 infected infect VBN cord-294218-v4gjabp3 99 7 cell cell NN cord-294218-v4gjabp3 99 8 cultures culture NNS cord-294218-v4gjabp3 99 9 were be VBD cord-294218-v4gjabp3 99 10 then then RB cord-294218-v4gjabp3 99 11 immunoprecipitated immunoprecipitate VBN cord-294218-v4gjabp3 99 12 with with IN cord-294218-v4gjabp3 99 13 the the DT cord-294218-v4gjabp3 99 14 rabbit rabbit NN cord-294218-v4gjabp3 99 15 anti anti JJ cord-294218-v4gjabp3 99 16 - - NNP cord-294218-v4gjabp3 99 17 TCV TCV NNP cord-294218-v4gjabp3 99 18 hyperimmune hyperimmune NNP cord-294218-v4gjabp3 99 19 serum serum NN cord-294218-v4gjabp3 99 20 , , , cord-294218-v4gjabp3 99 21 and and CC cord-294218-v4gjabp3 99 22 the the DT cord-294218-v4gjabp3 99 23 precipitates precipitate NNS cord-294218-v4gjabp3 99 24 were be VBD cord-294218-v4gjabp3 99 25 analyzed analyze VBN cord-294218-v4gjabp3 99 26 by by IN cord-294218-v4gjabp3 99 27 SDS SDS NNP cord-294218-v4gjabp3 99 28 - - HYPH cord-294218-v4gjabp3 99 29 PAGE PAGE NNP cord-294218-v4gjabp3 99 30 . . . cord-294218-v4gjabp3 100 1 As as IN cord-294218-v4gjabp3 100 2 shown show VBN cord-294218-v4gjabp3 100 3 in in IN cord-294218-v4gjabp3 100 4 Fig Fig NNP cord-294218-v4gjabp3 100 5 . . . cord-294218-v4gjabp3 101 1 2 2 LS cord-294218-v4gjabp3 101 2 , , , cord-294218-v4gjabp3 101 3 pulse pulse NN cord-294218-v4gjabp3 101 4 - - HYPH cord-294218-v4gjabp3 101 5 chase chase NN cord-294218-v4gjabp3 101 6 experiments experiment NNS cord-294218-v4gjabp3 101 7 conducted conduct VBN cord-294218-v4gjabp3 101 8 at at IN cord-294218-v4gjabp3 101 9 7 7 CD cord-294218-v4gjabp3 101 10 and and CC cord-294218-v4gjabp3 101 11 8 8 CD cord-294218-v4gjabp3 101 12 hours hour NNS cord-294218-v4gjabp3 101 13 after after IN cord-294218-v4gjabp3 101 14 infection infection NN cord-294218-v4gjabp3 101 15 permitted permit VBD cord-294218-v4gjabp3 101 16 the the DT cord-294218-v4gjabp3 101 17 identification identification NN cord-294218-v4gjabp3 101 18 of of IN cord-294218-v4gjabp3 101 19 new new JJ cord-294218-v4gjabp3 101 20 immunoprecipitable immunoprecipitable JJ cord-294218-v4gjabp3 101 21 protein protein NN cord-294218-v4gjabp3 101 22 species specie NNS cord-294218-v4gjabp3 101 23 with with IN cord-294218-v4gjabp3 101 24 mol.wts mol.wt NNS cord-294218-v4gjabp3 101 25 , , , cord-294218-v4gjabp3 101 26 of of IN cord-294218-v4gjabp3 101 27 approximately approximately RB cord-294218-v4gjabp3 101 28 150,000 150,000 CD cord-294218-v4gjabp3 101 29 to to IN cord-294218-v4gjabp3 101 30 170,000 170,000 CD cord-294218-v4gjabp3 101 31 , , , cord-294218-v4gjabp3 101 32 120,000 120,000 CD cord-294218-v4gjabp3 101 33 , , , cord-294218-v4gjabp3 101 34 90,000 90,000 CD cord-294218-v4gjabp3 101 35 , , , cord-294218-v4gjabp3 101 36 62,000 62,000 CD cord-294218-v4gjabp3 101 37 , , , cord-294218-v4gjabp3 101 38 and and CC cord-294218-v4gjabp3 101 39 22 22 CD cord-294218-v4gjabp3 101 40 - - SYM cord-294218-v4gjabp3 101 41 24,000 24,000 CD cord-294218-v4gjabp3 101 42 . . . cord-294218-v4gjabp3 102 1 No no DT cord-294218-v4gjabp3 102 2 processing processing NN cord-294218-v4gjabp3 102 3 of of IN cord-294218-v4gjabp3 102 4 the the DT cord-294218-v4gjabp3 102 5 major major JJ cord-294218-v4gjabp3 102 6 p52 p52 NNP cord-294218-v4gjabp3 102 7 nucleocapsid nucleocapsid NNP cord-294218-v4gjabp3 102 8 protein protein NN cord-294218-v4gjabp3 102 9 was be VBD cord-294218-v4gjabp3 102 10 apparent apparent JJ cord-294218-v4gjabp3 102 11 during during IN cord-294218-v4gjabp3 102 12 the the DT cord-294218-v4gjabp3 102 13 4 4 CD cord-294218-v4gjabp3 102 14 hourchase hourchase NN cord-294218-v4gjabp3 102 15 period period NN cord-294218-v4gjabp3 102 16 , , , cord-294218-v4gjabp3 102 17 but but CC cord-294218-v4gjabp3 102 18 significant significant JJ cord-294218-v4gjabp3 102 19 variation variation NN cord-294218-v4gjabp3 102 20 was be VBD cord-294218-v4gjabp3 102 21 noted note VBN cord-294218-v4gjabp3 102 22 in in IN cord-294218-v4gjabp3 102 23 the the DT cord-294218-v4gjabp3 102 24 intensity intensity NN cord-294218-v4gjabp3 102 25 of of IN cord-294218-v4gjabp3 102 26 the the DT cord-294218-v4gjabp3 102 27 200,000 200,000 CD cord-294218-v4gjabp3 102 28 , , , cord-294218-v4gjabp3 102 29 140,000 140,000 CD cord-294218-v4gjabp3 102 30 , , , cord-294218-v4gjabp3 102 31 and and CC cord-294218-v4gjabp3 102 32 100,000 100,000 CD cord-294218-v4gjabp3 102 33 protein protein NN cord-294218-v4gjabp3 102 34 bands band NNS cord-294218-v4gjabp3 102 35 . . . cord-294218-v4gjabp3 103 1 The the DT cord-294218-v4gjabp3 103 2 62,000 62,000 CD cord-294218-v4gjabp3 103 3 mol.wt mol.wt NNP cord-294218-v4gjabp3 103 4 , , , cord-294218-v4gjabp3 103 5 species species NN cord-294218-v4gjabp3 103 6 was be VBD cord-294218-v4gjabp3 103 7 present present JJ cord-294218-v4gjabp3 103 8 during during IN cord-294218-v4gjabp3 103 9 the the DT cord-294218-v4gjabp3 103 10 first first JJ cord-294218-v4gjabp3 103 11 hour hour NN cord-294218-v4gjabp3 103 12 of of IN cord-294218-v4gjabp3 103 13 the the DT cord-294218-v4gjabp3 103 14 chase chase NN cord-294218-v4gjabp3 103 15 period period NN cord-294218-v4gjabp3 103 16 and and CC cord-294218-v4gjabp3 103 17 then then RB cord-294218-v4gjabp3 103 18 disappeared disappear VBD cord-294218-v4gjabp3 103 19 from from IN cord-294218-v4gjabp3 103 20 the the DT cord-294218-v4gjabp3 103 21 gel gel NN cord-294218-v4gjabp3 103 22 , , , cord-294218-v4gjabp3 103 23 concomitant concomitant JJ cord-294218-v4gjabp3 103 24 with with IN cord-294218-v4gjabp3 103 25 the the DT cord-294218-v4gjabp3 103 26 appearance appearance NN cord-294218-v4gjabp3 103 27 of of IN cord-294218-v4gjabp3 103 28 a a DT cord-294218-v4gjabp3 103 29 weak weak JJ cord-294218-v4gjabp3 103 30 band band NN cord-294218-v4gjabp3 103 31 corresponding correspond VBG cord-294218-v4gjabp3 103 32 to to IN cord-294218-v4gjabp3 103 33 a a DT cord-294218-v4gjabp3 103 34 polypeptide polypeptide NN cord-294218-v4gjabp3 103 35 with with IN cord-294218-v4gjabp3 103 36 an an DT cord-294218-v4gjabp3 103 37 approximative approximative JJ cord-294218-v4gjabp3 103 38 mol.wt mol.wt NN cord-294218-v4gjabp3 103 39 , , , cord-294218-v4gjabp3 103 40 of of IN cord-294218-v4gjabp3 103 41 130,000 130,000 CD cord-294218-v4gjabp3 103 42 , , , cord-294218-v4gjabp3 103 43 which which WDT cord-294218-v4gjabp3 103 44 later later RB cord-294218-v4gjabp3 103 45 seemed seem VBD cord-294218-v4gjabp3 103 46 to to TO cord-294218-v4gjabp3 103 47 be be VB cord-294218-v4gjabp3 103 48 converted convert VBN cord-294218-v4gjabp3 103 49 into into IN cord-294218-v4gjabp3 103 50 the the DT cord-294218-v4gjabp3 103 51 gp gp NN cord-294218-v4gjabp3 103 52 140 140 CD cord-294218-v4gjabp3 103 53 species specie NNS cord-294218-v4gjabp3 103 54 . . . cord-294218-v4gjabp3 104 1 The the DT cord-294218-v4gjabp3 104 2 90,000 90,000 CD cord-294218-v4gjabp3 104 3 mol.wt mol.wt NNP cord-294218-v4gjabp3 104 4 , , , cord-294218-v4gjabp3 104 5 species specie NNS cord-294218-v4gjabp3 104 6 , , , cord-294218-v4gjabp3 104 7 present present JJ cord-294218-v4gjabp3 104 8 since since IN cord-294218-v4gjabp3 104 9 the the DT cord-294218-v4gjabp3 104 10 beginning beginning NN cord-294218-v4gjabp3 104 11 of of IN cord-294218-v4gjabp3 104 12 the the DT cord-294218-v4gjabp3 104 13 chase chase NN cord-294218-v4gjabp3 104 14 period period NN cord-294218-v4gjabp3 104 15 , , , cord-294218-v4gjabp3 104 16 was be VBD cord-294218-v4gjabp3 104 17 progressively progressively RB cord-294218-v4gjabp3 104 18 chased chase VBN cord-294218-v4gjabp3 104 19 to to TO cord-294218-v4gjabp3 104 20 give give VB cord-294218-v4gjabp3 104 21 the the DT cord-294218-v4gjabp3 104 22 final final JJ cord-294218-v4gjabp3 104 23 gp gp NN cord-294218-v4gjabp3 104 24 100 100 CD cord-294218-v4gjabp3 104 25 species specie NNS cord-294218-v4gjabp3 104 26 . . . cord-294218-v4gjabp3 105 1 The the DT cord-294218-v4gjabp3 105 2 120,000 120,000 CD cord-294218-v4gjabp3 105 3 protein protein NN cord-294218-v4gjabp3 105 4 species specie NNS cord-294218-v4gjabp3 105 5 was be VBD cord-294218-v4gjabp3 105 6 also also RB cord-294218-v4gjabp3 105 7 present present JJ cord-294218-v4gjabp3 105 8 from from IN cord-294218-v4gjabp3 105 9 the the DT cord-294218-v4gjabp3 105 10 beginning beginning NN cord-294218-v4gjabp3 105 11 of of IN cord-294218-v4gjabp3 105 12 the the DT cord-294218-v4gjabp3 105 13 chase chase NN cord-294218-v4gjabp3 105 14 period period NN cord-294218-v4gjabp3 105 15 and and CC cord-294218-v4gjabp3 105 16 increased increase VBD cord-294218-v4gjabp3 105 17 in in IN cord-294218-v4gjabp3 105 18 intensity intensity NN cord-294218-v4gjabp3 105 19 without without IN cord-294218-v4gjabp3 105 20 any any DT cord-294218-v4gjabp3 105 21 apparent apparent JJ cord-294218-v4gjabp3 105 22 change change NN cord-294218-v4gjabp3 105 23 in in IN cord-294218-v4gjabp3 105 24 its -PRON- PRP$ cord-294218-v4gjabp3 105 25 electrophoretic electrophoretic JJ cord-294218-v4gjabp3 105 26 mobility mobility NN cord-294218-v4gjabp3 105 27 . . . cord-294218-v4gjabp3 106 1 The the DT cord-294218-v4gjabp3 106 2 150 150 CD cord-294218-v4gjabp3 106 3 to to IN cord-294218-v4gjabp3 106 4 170,000 170,000 CD cord-294218-v4gjabp3 106 5 mol.wt mol.wt NN cord-294218-v4gjabp3 106 6 , , , cord-294218-v4gjabp3 106 7 species specie NNS cord-294218-v4gjabp3 106 8 was be VBD cord-294218-v4gjabp3 106 9 evident evident JJ cord-294218-v4gjabp3 106 10 after after IN cord-294218-v4gjabp3 106 11 45 45 CD cord-294218-v4gjabp3 106 12 rain rain NN cord-294218-v4gjabp3 106 13 , , , cord-294218-v4gjabp3 106 14 and and CC cord-294218-v4gjabp3 106 15 remained remain VBD cord-294218-v4gjabp3 106 16 detectable detectable JJ cord-294218-v4gjabp3 106 17 until until IN cord-294218-v4gjabp3 106 18 the the DT cord-294218-v4gjabp3 106 19 end end NN cord-294218-v4gjabp3 106 20 of of IN cord-294218-v4gjabp3 106 21 the the DT cord-294218-v4gjabp3 106 22 chase chase NN cord-294218-v4gjabp3 106 23 period period NN cord-294218-v4gjabp3 106 24 . . . cord-294218-v4gjabp3 107 1 The the DT cord-294218-v4gjabp3 107 2 200,000 200,000 CD cord-294218-v4gjabp3 107 3 protein protein NN cord-294218-v4gjabp3 107 4 band band NN cord-294218-v4gjabp3 107 5 intensified intensify VBD cord-294218-v4gjabp3 107 6 as as IN cord-294218-v4gjabp3 107 7 the the DT cord-294218-v4gjabp3 107 8 infection infection NN cord-294218-v4gjabp3 107 9 progressed progress VBD cord-294218-v4gjabp3 107 10 , , , cord-294218-v4gjabp3 107 11 concomitant concomitant JJ cord-294218-v4gjabp3 107 12 with with IN cord-294218-v4gjabp3 107 13 an an DT cord-294218-v4gjabp3 107 14 increase increase NN cord-294218-v4gjabp3 107 15 in in IN cord-294218-v4gjabp3 107 16 the the DT cord-294218-v4gjabp3 107 17 intensity intensity NN cord-294218-v4gjabp3 107 18 of of IN cord-294218-v4gjabp3 107 19 gp gp NNP cord-294218-v4gjabp3 107 20 100 100 CD cord-294218-v4gjabp3 107 21 and and CC cord-294218-v4gjabp3 107 22 the the DT cord-294218-v4gjabp3 107 23 120,000 120,000 CD cord-294218-v4gjabp3 107 24 mol.wt mol.wt NNP cord-294218-v4gjabp3 107 25 , , , cord-294218-v4gjabp3 107 26 species specie NNS cord-294218-v4gjabp3 107 27 . . . cord-294218-v4gjabp3 108 1 The the DT cord-294218-v4gjabp3 108 2 higher high JJR cord-294218-v4gjabp3 108 3 mol.wt mol.wt NNP cord-294218-v4gjabp3 108 4 . . . cord-294218-v4gjabp3 109 1 polypeptide polypeptide NN cord-294218-v4gjabp3 109 2 disappeared disappear VBD cord-294218-v4gjabp3 109 3 later later RB cord-294218-v4gjabp3 109 4 during during IN cord-294218-v4gjabp3 109 5 the the DT cord-294218-v4gjabp3 109 6 infection infection NN cord-294218-v4gjabp3 109 7 . . . cord-294218-v4gjabp3 110 1 Processing processing NN cord-294218-v4gjabp3 110 2 seemed seem VBD cord-294218-v4gjabp3 110 3 also also RB cord-294218-v4gjabp3 110 4 to to TO cord-294218-v4gjabp3 110 5 occurred occur VBD cord-294218-v4gjabp3 110 6 among among IN cord-294218-v4gjabp3 110 7 lower low JJR cord-294218-v4gjabp3 110 8 mol.wt mol.wt NNP cord-294218-v4gjabp3 110 9 , , , cord-294218-v4gjabp3 110 10 proteins protein NNS cord-294218-v4gjabp3 110 11 . . . cord-294218-v4gjabp3 111 1 A a DT cord-294218-v4gjabp3 111 2 36,000 36,000 CD cord-294218-v4gjabp3 111 3 mol.wt mol.wt NNP cord-294218-v4gjabp3 111 4 , , , cord-294218-v4gjabp3 111 5 protein protein NN cord-294218-v4gjabp3 111 6 , , , cord-294218-v4gjabp3 111 7 co co NN cord-294218-v4gjabp3 111 8 - - NN cord-294218-v4gjabp3 111 9 migrating migrate VBG cord-294218-v4gjabp3 111 10 with with IN cord-294218-v4gjabp3 111 11 a a DT cord-294218-v4gjabp3 111 12 protein protein NN cord-294218-v4gjabp3 111 13 present present NN cord-294218-v4gjabp3 111 14 in in IN cord-294218-v4gjabp3 111 15 mock mock JJ cord-294218-v4gjabp3 111 16 - - HYPH cord-294218-v4gjabp3 111 17 infected infected JJ cord-294218-v4gjabp3 111 18 cell cell NN cord-294218-v4gjabp3 111 19 lysates lysate NNS cord-294218-v4gjabp3 111 20 ( ( -LRB- cord-294218-v4gjabp3 111 21 data datum NNS cord-294218-v4gjabp3 111 22 not not RB cord-294218-v4gjabp3 111 23 shown show VBN cord-294218-v4gjabp3 111 24 ) ) -RRB- cord-294218-v4gjabp3 111 25 , , , cord-294218-v4gjabp3 111 26 appeared appear VBD cord-294218-v4gjabp3 111 27 to to TO cord-294218-v4gjabp3 111 28 be be VB cord-294218-v4gjabp3 111 29 chased chase VBN cord-294218-v4gjabp3 111 30 into into IN cord-294218-v4gjabp3 111 31 a a DT cord-294218-v4gjabp3 111 32 38,000 38,000 CD cord-294218-v4gjabp3 111 33 mol.wt mol.wt NN cord-294218-v4gjabp3 111 34 , , , cord-294218-v4gjabp3 111 35 species specie NNS cord-294218-v4gjabp3 111 36 . . . cord-294218-v4gjabp3 112 1 A a DT cord-294218-v4gjabp3 112 2 minor minor JJ cord-294218-v4gjabp3 112 3 band band NN cord-294218-v4gjabp3 112 4 of of IN cord-294218-v4gjabp3 112 5 44,000 44,000 CD cord-294218-v4gjabp3 112 6 also also RB cord-294218-v4gjabp3 112 7 appeared appear VBD cord-294218-v4gjabp3 112 8 in in IN cord-294218-v4gjabp3 112 9 the the DT cord-294218-v4gjabp3 112 10 gels gel NNS cord-294218-v4gjabp3 112 11 after after IN cord-294218-v4gjabp3 112 12 the the DT cord-294218-v4gjabp3 112 13 first first JJ cord-294218-v4gjabp3 112 14 hour hour NN cord-294218-v4gjabp3 112 15 of of IN cord-294218-v4gjabp3 112 16 the the DT cord-294218-v4gjabp3 112 17 chase chase NN cord-294218-v4gjabp3 112 18 period period NN cord-294218-v4gjabp3 112 19 . . . cord-294218-v4gjabp3 113 1 Processing processing NN cord-294218-v4gjabp3 113 2 of of IN cord-294218-v4gjabp3 113 3 the the DT cord-294218-v4gjabp3 113 4 small small JJ cord-294218-v4gjabp3 113 5 matrix matrix NN cord-294218-v4gjabp3 113 6 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 113 7 could could MD cord-294218-v4gjabp3 113 8 hardly hardly RB cord-294218-v4gjabp3 113 9 be be VB cord-294218-v4gjabp3 113 10 demonstrated demonstrate VBN cord-294218-v4gjabp3 113 11 by by IN cord-294218-v4gjabp3 113 12 immunoprecipitation immunoprecipitation NN cord-294218-v4gjabp3 113 13 . . . cord-294218-v4gjabp3 114 1 However however RB cord-294218-v4gjabp3 114 2 , , , cord-294218-v4gjabp3 114 3 by by IN cord-294218-v4gjabp3 114 4 SDS SDS NNP cord-294218-v4gjabp3 114 5 - - HYPH cord-294218-v4gjabp3 114 6 PAGE PAGE NNP cord-294218-v4gjabp3 114 7 analysis analysis NN cord-294218-v4gjabp3 114 8 of of IN cord-294218-v4gjabp3 114 9 cell cell NN cord-294218-v4gjabp3 114 10 lysates lysate NNS cord-294218-v4gjabp3 114 11 obtained obtain VBN cord-294218-v4gjabp3 114 12 after after IN cord-294218-v4gjabp3 114 13 various various JJ cord-294218-v4gjabp3 114 14 chase chase NN cord-294218-v4gjabp3 114 15 periods period NNS cord-294218-v4gjabp3 114 16 , , , cord-294218-v4gjabp3 114 17 an an DT cord-294218-v4gjabp3 114 18 increase increase NN cord-294218-v4gjabp3 114 19 in in IN cord-294218-v4gjabp3 114 20 the the DT cord-294218-v4gjabp3 114 21 intensity intensity NN cord-294218-v4gjabp3 114 22 of of IN cord-294218-v4gjabp3 114 23 the the DT cord-294218-v4gjabp3 114 24 24,000 24,000 CD cord-294218-v4gjabp3 114 25 protein protein NN cord-294218-v4gjabp3 114 26 band band NN cord-294218-v4gjabp3 114 27 was be VBD cord-294218-v4gjabp3 114 28 noted note VBN cord-294218-v4gjabp3 114 29 concomitant concomitant JJ cord-294218-v4gjabp3 114 30 with with IN cord-294218-v4gjabp3 114 31 a a DT cord-294218-v4gjabp3 114 32 decrease decrease NN cord-294218-v4gjabp3 114 33 in in IN cord-294218-v4gjabp3 114 34 the the DT cord-294218-v4gjabp3 114 35 20 20 CD cord-294218-v4gjabp3 114 36 - - SYM cord-294218-v4gjabp3 114 37 22,000 22,000 CD cord-294218-v4gjabp3 114 38 protein protein NN cord-294218-v4gjabp3 114 39 band band NN cord-294218-v4gjabp3 114 40 , , , cord-294218-v4gjabp3 114 41 presumably presumably RB cord-294218-v4gjabp3 114 42 due due IN cord-294218-v4gjabp3 114 43 to to IN cord-294218-v4gjabp3 114 44 the the DT cord-294218-v4gjabp3 114 45 glycosylation glycosylation NN cord-294218-v4gjabp3 114 46 of of IN cord-294218-v4gjabp3 114 47 the the DT cord-294218-v4gjabp3 114 48 p20 p20 NNP cord-294218-v4gjabp3 114 49 - - HYPH cord-294218-v4gjabp3 114 50 22 22 CD cord-294218-v4gjabp3 114 51 to to TO cord-294218-v4gjabp3 114 52 form form VB cord-294218-v4gjabp3 114 53 the the DT cord-294218-v4gjabp3 114 54 gp24 gp24 NNP cord-294218-v4gjabp3 114 55 ( ( -LRB- cord-294218-v4gjabp3 114 56 Fig Fig NNP cord-294218-v4gjabp3 114 57 . . . cord-294218-v4gjabp3 114 58 2B 2b CD cord-294218-v4gjabp3 114 59 ) ) -RRB- cord-294218-v4gjabp3 114 60 . . . cord-294218-v4gjabp3 115 1 The the DT cord-294218-v4gjabp3 115 2 immunoprecipitations immunoprecipitation NNS cord-294218-v4gjabp3 115 3 of of IN cord-294218-v4gjabp3 115 4 chased chase VBN cord-294218-v4gjabp3 115 5 lysates lysate NNS cord-294218-v4gjabp3 115 6 with with IN cord-294218-v4gjabp3 115 7 pre pre JJ cord-294218-v4gjabp3 115 8 - - JJ cord-294218-v4gjabp3 115 9 immune immune JJ cord-294218-v4gjabp3 115 10 serum serum NN cord-294218-v4gjabp3 115 11 were be VBD cord-294218-v4gjabp3 115 12 all all DT cord-294218-v4gjabp3 115 13 negative negative JJ cord-294218-v4gjabp3 115 14 , , , cord-294218-v4gjabp3 115 15 as as IN cord-294218-v4gjabp3 115 16 was be VBD cord-294218-v4gjabp3 115 17 the the DT cord-294218-v4gjabp3 115 18 immunoprecipitation immunoprecipitation NN cord-294218-v4gjabp3 115 19 of of IN cord-294218-v4gjabp3 115 20 uninfected uninfected JJ cord-294218-v4gjabp3 115 21 lysates lysate NNS cord-294218-v4gjabp3 115 22 with with IN cord-294218-v4gjabp3 115 23 the the DT cord-294218-v4gjabp3 115 24 specific specific JJ cord-294218-v4gjabp3 115 25 hyperimmune hyperimmune NNP cord-294218-v4gjabp3 115 26 serum serum NN cord-294218-v4gjabp3 115 27 ( ( -LRB- cord-294218-v4gjabp3 115 28 data datum NNS cord-294218-v4gjabp3 115 29 not not RB cord-294218-v4gjabp3 115 30 shown show VBN cord-294218-v4gjabp3 115 31 ) ) -RRB- cord-294218-v4gjabp3 115 32 . . . cord-294218-v4gjabp3 116 1 To to TO cord-294218-v4gjabp3 116 2 determine determine VB cord-294218-v4gjabp3 116 3 the the DT cord-294218-v4gjabp3 116 4 nature nature NN cord-294218-v4gjabp3 116 5 of of IN cord-294218-v4gjabp3 116 6 the the DT cord-294218-v4gjabp3 116 7 glycosidic glycosidic JJ cord-294218-v4gjabp3 116 8 bonds bond NNS cord-294218-v4gjabp3 116 9 present present JJ cord-294218-v4gjabp3 116 10 on on IN cord-294218-v4gjabp3 116 11 each each DT cord-294218-v4gjabp3 116 12 TCV TCV NNP cord-294218-v4gjabp3 116 13 glycoprotein glycoprotein NN cord-294218-v4gjabp3 116 14 , , , cord-294218-v4gjabp3 116 15 infected infected JJ cord-294218-v4gjabp3 116 16 and and CC cord-294218-v4gjabp3 116 17 mock mock JJ cord-294218-v4gjabp3 116 18 - - HYPH cord-294218-v4gjabp3 116 19 infected infect VBN cord-294218-v4gjabp3 116 20 cells cell NNS cord-294218-v4gjabp3 116 21 were be VBD cord-294218-v4gjabp3 116 22 maintained maintain VBN cord-294218-v4gjabp3 116 23 in in IN cord-294218-v4gjabp3 116 24 media medium NNS cord-294218-v4gjabp3 116 25 supplemented supplement VBN cord-294218-v4gjabp3 116 26 with with IN cord-294218-v4gjabp3 116 27 either either DT cord-294218-v4gjabp3 116 28 tunicamycin tunicamycin NNS cord-294218-v4gjabp3 116 29 ( ( -LRB- cord-294218-v4gjabp3 116 30 TM TM NNP cord-294218-v4gjabp3 116 31 ) ) -RRB- cord-294218-v4gjabp3 116 32 or or CC cord-294218-v4gjabp3 116 33 sodium sodium NN cord-294218-v4gjabp3 116 34 monensin monensin NNP cord-294218-v4gjabp3 116 35 ( ( -LRB- cord-294218-v4gjabp3 116 36 SM SM NNP cord-294218-v4gjabp3 116 37 ) ) -RRB- cord-294218-v4gjabp3 116 38 and and CC cord-294218-v4gjabp3 116 39 pulselabeled pulselabele VBN cord-294218-v4gjabp3 116 40 with with IN cord-294218-v4gjabp3 116 41 [ [ -LRB- cord-294218-v4gjabp3 116 42 35S]methionine 35s]methionine CD cord-294218-v4gjabp3 116 43 or or CC cord-294218-v4gjabp3 116 44 [ [ -LRB- cord-294218-v4gjabp3 116 45 3H]glucosamine 3h]glucosamine CD cord-294218-v4gjabp3 116 46 to to TO cord-294218-v4gjabp3 116 47 follow follow VB cord-294218-v4gjabp3 116 48 the the DT cord-294218-v4gjabp3 116 49 effects effect NNS cord-294218-v4gjabp3 116 50 of of IN cord-294218-v4gjabp3 116 51 the the DT cord-294218-v4gjabp3 116 52 inhibitors inhibitor NNS cord-294218-v4gjabp3 116 53 on on IN cord-294218-v4gjabp3 116 54 synthesis synthesis NN cord-294218-v4gjabp3 116 55 and and CC cord-294218-v4gjabp3 116 56 glycosylation glycosylation NN cord-294218-v4gjabp3 116 57 of of IN cord-294218-v4gjabp3 116 58 TCV tcv NN cord-294218-v4gjabp3 116 59 - - HYPH cord-294218-v4gjabp3 116 60 induced induce VBN cord-294218-v4gjabp3 116 61 intracellular intracellular JJ cord-294218-v4gjabp3 116 62 proteins protein NNS cord-294218-v4gjabp3 116 63 . . . cord-294218-v4gjabp3 117 1 No no DT cord-294218-v4gjabp3 117 2 cytopathic cytopathic JJ cord-294218-v4gjabp3 117 3 changes change NNS cord-294218-v4gjabp3 117 4 or or CC cord-294218-v4gjabp3 117 5 polycaryocytosis polycaryocytosis NN cord-294218-v4gjabp3 117 6 were be VBD cord-294218-v4gjabp3 117 7 observed observe VBN cord-294218-v4gjabp3 117 8 when when WRB cord-294218-v4gjabp3 117 9 TCV TCV NNP cord-294218-v4gjabp3 117 10 - - HYPH cord-294218-v4gjabp3 117 11 infected infect VBN cord-294218-v4gjabp3 117 12 cell cell NN cord-294218-v4gjabp3 117 13 cultures culture NNS cord-294218-v4gjabp3 117 14 were be VBD cord-294218-v4gjabp3 117 15 grown grow VBN cord-294218-v4gjabp3 117 16 in in IN cord-294218-v4gjabp3 117 17 the the DT cord-294218-v4gjabp3 117 18 presence presence NN cord-294218-v4gjabp3 117 19 of of IN cord-294218-v4gjabp3 117 20 0.5 0.5 CD cord-294218-v4gjabp3 117 21 or or CC cord-294218-v4gjabp3 117 22 1.0 1.0 CD cord-294218-v4gjabp3 117 23 ~tg ~tg NNS cord-294218-v4gjabp3 117 24 / / SYM cord-294218-v4gjabp3 117 25 ml ml NN cord-294218-v4gjabp3 117 26 of of IN cord-294218-v4gjabp3 117 27 TM TM NNP cord-294218-v4gjabp3 117 28 . . . cord-294218-v4gjabp3 118 1 In in IN cord-294218-v4gjabp3 118 2 contrast contrast NN cord-294218-v4gjabp3 118 3 , , , cord-294218-v4gjabp3 118 4 the the DT cord-294218-v4gjabp3 118 5 addition addition NN cord-294218-v4gjabp3 118 6 of of IN cord-294218-v4gjabp3 118 7 0.5 0.5 CD cord-294218-v4gjabp3 118 8 to to TO cord-294218-v4gjabp3 118 9 2.5 2.5 CD cord-294218-v4gjabp3 118 10 ~tM ~tM NNP cord-294218-v4gjabp3 118 11 sodium sodium NN cord-294218-v4gjabp3 118 12 monensin monensin NNP cord-294218-v4gjabp3 118 13 did do VBD cord-294218-v4gjabp3 118 14 not not RB cord-294218-v4gjabp3 118 15 interfere interfere VB cord-294218-v4gjabp3 118 16 with with IN cord-294218-v4gjabp3 118 17 Tunicamycin Tunicamycin NNP cord-294218-v4gjabp3 118 18 at at IN cord-294218-v4gjabp3 118 19 a a DT cord-294218-v4gjabp3 118 20 concentration concentration NN cord-294218-v4gjabp3 118 21 of of IN cord-294218-v4gjabp3 118 22 0.5 0.5 CD cord-294218-v4gjabp3 118 23 lag lag NN cord-294218-v4gjabp3 118 24 / / SYM cord-294218-v4gjabp3 118 25 ml ml XX cord-294218-v4gjabp3 118 26 slightly slightly RB cord-294218-v4gjabp3 118 27 decreased decrease VBD cord-294218-v4gjabp3 118 28 the the DT cord-294218-v4gjabp3 118 29 overall overall JJ cord-294218-v4gjabp3 118 30 intracellular intracellular JJ cord-294218-v4gjabp3 118 31 protein protein NN cord-294218-v4gjabp3 118 32 synthesis synthesis NN cord-294218-v4gjabp3 118 33 , , , cord-294218-v4gjabp3 118 34 as as IN cord-294218-v4gjabp3 118 35 suggested suggest VBN cord-294218-v4gjabp3 118 36 by by IN cord-294218-v4gjabp3 118 37 the the DT cord-294218-v4gjabp3 118 38 intensity intensity NN cord-294218-v4gjabp3 118 39 of of IN cord-294218-v4gjabp3 118 40 bands band NNS cord-294218-v4gjabp3 118 41 of of IN cord-294218-v4gjabp3 118 42 [ [ -LRB- cord-294218-v4gjabp3 118 43 35S]methionine 35s]methionine CD cord-294218-v4gjabp3 118 44 - - HYPH cord-294218-v4gjabp3 118 45 labeled label VBN cord-294218-v4gjabp3 118 46 proteins protein NNS cord-294218-v4gjabp3 118 47 resolved resolve VBN cord-294218-v4gjabp3 118 48 by by IN cord-294218-v4gjabp3 118 49 SDS SDS NNP cord-294218-v4gjabp3 118 50 - - HYPH cord-294218-v4gjabp3 118 51 PAGE PAGE NNP cord-294218-v4gjabp3 118 52 of of IN cord-294218-v4gjabp3 118 53 cell cell NN cord-294218-v4gjabp3 118 54 lysates lysate NNS cord-294218-v4gjabp3 118 55 . . . cord-294218-v4gjabp3 119 1 Polypeptides polypeptide NNS cord-294218-v4gjabp3 119 2 corresponding correspond VBG cord-294218-v4gjabp3 119 3 to to IN cord-294218-v4gjabp3 119 4 TCV TCV NNP cord-294218-v4gjabp3 119 5 peplomeric peplomeric JJ cord-294218-v4gjabp3 119 6 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 119 7 showed show VBD cord-294218-v4gjabp3 119 8 a a DT cord-294218-v4gjabp3 119 9 drastic drastic JJ cord-294218-v4gjabp3 119 10 decrease decrease NN cord-294218-v4gjabp3 119 11 in in IN cord-294218-v4gjabp3 119 12 their -PRON- PRP$ cord-294218-v4gjabp3 119 13 apparent apparent JJ cord-294218-v4gjabp3 119 14 molecular molecular JJ cord-294218-v4gjabp3 119 15 weights weight NNS cord-294218-v4gjabp3 119 16 , , , cord-294218-v4gjabp3 119 17 yielding yield VBG cord-294218-v4gjabp3 119 18 90,000 90,000 CD cord-294218-v4gjabp3 119 19 , , , cord-294218-v4gjabp3 119 20 120 120 CD cord-294218-v4gjabp3 119 21 - - SYM cord-294218-v4gjabp3 119 22 130,000 130,000 CD cord-294218-v4gjabp3 119 23 , , , cord-294218-v4gjabp3 119 24 and and CC cord-294218-v4gjabp3 119 25 150,000 150,000 CD cord-294218-v4gjabp3 119 26 polypeptide polypeptide NN cord-294218-v4gjabp3 119 27 species specie NNS cord-294218-v4gjabp3 119 28 ( ( -LRB- cord-294218-v4gjabp3 119 29 Fig fig NN cord-294218-v4gjabp3 119 30 . . . cord-294218-v4gjabp3 119 31 3 3 CD cord-294218-v4gjabp3 119 32 A a NN cord-294218-v4gjabp3 119 33 , , , cord-294218-v4gjabp3 119 34 arrowheads arrowhead NNS cord-294218-v4gjabp3 119 35 ) ) -RRB- cord-294218-v4gjabp3 119 36 . . . cord-294218-v4gjabp3 120 1 These these DT cord-294218-v4gjabp3 120 2 new new JJ cord-294218-v4gjabp3 120 3 intracellular intracellular JJ cord-294218-v4gjabp3 120 4 polypeptides polypeptide NNS cord-294218-v4gjabp3 120 5 were be VBD cord-294218-v4gjabp3 120 6 also also RB cord-294218-v4gjabp3 120 7 resolved resolve VBN cord-294218-v4gjabp3 120 8 by by IN cord-294218-v4gjabp3 120 9 Western western JJ cord-294218-v4gjabp3 120 10 immunoblotting immunoblotting NN cord-294218-v4gjabp3 120 11 ( ( -LRB- cord-294218-v4gjabp3 120 12 Fig fig NN cord-294218-v4gjabp3 120 13 . . . cord-294218-v4gjabp3 120 14 3 3 CD cord-294218-v4gjabp3 120 15 B b NN cord-294218-v4gjabp3 120 16 ) ) -RRB- cord-294218-v4gjabp3 120 17 . . . cord-294218-v4gjabp3 121 1 Radioim Radioim NNP cord-294218-v4gjabp3 121 2 - - HYPH cord-294218-v4gjabp3 121 3 munoprecipitation munoprecipitation NN cord-294218-v4gjabp3 121 4 experiments experiment NNS cord-294218-v4gjabp3 121 5 using use VBG cord-294218-v4gjabp3 121 6 the the DT cord-294218-v4gjabp3 121 7 anti anti JJ cord-294218-v4gjabp3 121 8 - - JJ cord-294218-v4gjabp3 121 9 TCV TCV NNP cord-294218-v4gjabp3 121 10 hyperimmune hyperimmune NNP cord-294218-v4gjabp3 121 11 serum serum NN cord-294218-v4gjabp3 121 12 , , , cord-294218-v4gjabp3 121 13 after after IN cord-294218-v4gjabp3 121 14 [ [ -LRB- cord-294218-v4gjabp3 121 15 35S]methionine 35s]methionine CD cord-294218-v4gjabp3 121 16 and and CC cord-294218-v4gjabp3 121 17 [ [ -LRB- cord-294218-v4gjabp3 121 18 3H]glucosamine 3h]glucosamine CD cord-294218-v4gjabp3 121 19 labeling labeling NN cord-294218-v4gjabp3 121 20 , , , cord-294218-v4gjabp3 121 21 confirmed confirm VBD cord-294218-v4gjabp3 121 22 the the DT cord-294218-v4gjabp3 121 23 absence absence NN cord-294218-v4gjabp3 121 24 of of IN cord-294218-v4gjabp3 121 25 the the DT cord-294218-v4gjabp3 121 26 peplomeric peplomeric JJ cord-294218-v4gjabp3 121 27 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 121 28 from from IN cord-294218-v4gjabp3 121 29 TM TM NNP cord-294218-v4gjabp3 121 30 - - HYPH cord-294218-v4gjabp3 121 31 treated treat VBN cord-294218-v4gjabp3 121 32 cells cell NNS cord-294218-v4gjabp3 121 33 , , , cord-294218-v4gjabp3 121 34 whereas whereas IN cord-294218-v4gjabp3 121 35 the the DT cord-294218-v4gjabp3 121 36 relative relative JJ cord-294218-v4gjabp3 121 37 amount amount NN cord-294218-v4gjabp3 121 38 of of IN cord-294218-v4gjabp3 121 39 the the DT cord-294218-v4gjabp3 121 40 unglycosylated unglycosylated JJ cord-294218-v4gjabp3 121 41 high high JJ cord-294218-v4gjabp3 121 42 mol.wt mol.wt NNP cord-294218-v4gjabp3 121 43 , , , cord-294218-v4gjabp3 121 44 polypeptide polypeptide NN cord-294218-v4gjabp3 121 45 species species NN cord-294218-v4gjabp3 121 46 increased increase VBD cord-294218-v4gjabp3 121 47 ( ( -LRB- cord-294218-v4gjabp3 121 48 Fig Fig NNP cord-294218-v4gjabp3 121 49 . . . cord-294218-v4gjabp3 121 50 4A 4a CD cord-294218-v4gjabp3 121 51 , , , cord-294218-v4gjabp3 121 52 lanes lane NNS cord-294218-v4gjabp3 121 53 _SP cord-294218-v4gjabp3 121 54 5 5 CD cord-294218-v4gjabp3 121 55 and and CC cord-294218-v4gjabp3 121 56 7 7 CD cord-294218-v4gjabp3 121 57 ) ) -RRB- cord-294218-v4gjabp3 121 58 . . . cord-294218-v4gjabp3 122 1 A a DT cord-294218-v4gjabp3 122 2 major major JJ cord-294218-v4gjabp3 122 3 non non JJ cord-294218-v4gjabp3 122 4 - - JJ cord-294218-v4gjabp3 122 5 glycosylated glycosylated JJ cord-294218-v4gjabp3 122 6 polypeptide polypeptide NN cord-294218-v4gjabp3 122 7 having have VBG cord-294218-v4gjabp3 122 8 a a DT cord-294218-v4gjabp3 122 9 mol.wt mol.wt NNP cord-294218-v4gjabp3 122 10 , , , cord-294218-v4gjabp3 122 11 of of IN cord-294218-v4gjabp3 122 12 60,000 60,000 CD cord-294218-v4gjabp3 122 13 was be VBD cord-294218-v4gjabp3 122 14 also also RB cord-294218-v4gjabp3 122 15 revealed reveal VBN cord-294218-v4gjabp3 122 16 in in IN cord-294218-v4gjabp3 122 17 the the DT cord-294218-v4gjabp3 122 18 presence presence NN cord-294218-v4gjabp3 122 19 of of IN cord-294218-v4gjabp3 122 20 TM TM NNP cord-294218-v4gjabp3 122 21 . . . cord-294218-v4gjabp3 123 1 In in IN cord-294218-v4gjabp3 123 2 contrast contrast NN cord-294218-v4gjabp3 123 3 , , , cord-294218-v4gjabp3 123 4 both both DT cord-294218-v4gjabp3 123 5 types type NNS cord-294218-v4gjabp3 123 6 of of IN cord-294218-v4gjabp3 123 7 surface surface NN cord-294218-v4gjabp3 123 8 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 123 9 ( ( -LRB- cord-294218-v4gjabp3 123 10 gpl80 gpl80 NNP cord-294218-v4gjabp3 123 11 - - HYPH cord-294218-v4gjabp3 123 12 200 200 CD cord-294218-v4gjabp3 123 13 / / SYM cord-294218-v4gjabp3 123 14 gpl00 gpl00 CD cord-294218-v4gjabp3 123 15 and and CC cord-294218-v4gjabp3 123 16 gp gp NNP cord-294218-v4gjabp3 123 17 140 140 CD cord-294218-v4gjabp3 123 18 ) ) -RRB- cord-294218-v4gjabp3 123 19 were be VBD cord-294218-v4gjabp3 123 20 immunoprecipitated immunoprecipitate VBN cord-294218-v4gjabp3 123 21 from from IN cord-294218-v4gjabp3 123 22 extracts extract NNS cord-294218-v4gjabp3 123 23 of of IN cord-294218-v4gjabp3 123 24 SM sm NN cord-294218-v4gjabp3 123 25 - - HYPH cord-294218-v4gjabp3 123 26 treated treat VBN cord-294218-v4gjabp3 123 27 TCV TCV NNP cord-294218-v4gjabp3 123 28 - - HYPH cord-294218-v4gjabp3 123 29 infected infect VBN cord-294218-v4gjabp3 123 30 cells cell NNS cord-294218-v4gjabp3 123 31 and and CC cord-294218-v4gjabp3 123 32 strongly strongly RB cord-294218-v4gjabp3 123 33 labeled label VBN cord-294218-v4gjabp3 123 34 with with IN cord-294218-v4gjabp3 123 35 [ [ -LRB- cord-294218-v4gjabp3 123 36 3H]glucosamine 3h]glucosamine NN cord-294218-v4gjabp3 123 37 ( ( -LRB- cord-294218-v4gjabp3 123 38 Fig Fig NNP cord-294218-v4gjabp3 123 39 . . . cord-294218-v4gjabp3 123 40 4A 4a CD cord-294218-v4gjabp3 123 41 , , , cord-294218-v4gjabp3 123 42 lane lane NN cord-294218-v4gjabp3 123 43 9 9 CD cord-294218-v4gjabp3 123 44 ) ) -RRB- cord-294218-v4gjabp3 123 45 . . . cord-294218-v4gjabp3 124 1 A a DT cord-294218-v4gjabp3 124 2 major major JJ cord-294218-v4gjabp3 124 3 polypeptide polypeptide NN cord-294218-v4gjabp3 124 4 with with IN cord-294218-v4gjabp3 124 5 an an DT cord-294218-v4gjabp3 124 6 approximate approximate JJ cord-294218-v4gjabp3 124 7 mol.wt mol.wt NNP cord-294218-v4gjabp3 124 8 , , , cord-294218-v4gjabp3 124 9 of of IN cord-294218-v4gjabp3 124 10 150 150 CD cord-294218-v4gjabp3 124 11 - - SYM cord-294218-v4gjabp3 124 12 170,000 170,000 CD cord-294218-v4gjabp3 124 13 was be VBD cord-294218-v4gjabp3 124 14 also also RB cord-294218-v4gjabp3 124 15 immunoprecipitated immunoprecipitate VBN cord-294218-v4gjabp3 124 16 after after IN cord-294218-v4gjabp3 124 17 treatment treatment NN cord-294218-v4gjabp3 124 18 with with IN cord-294218-v4gjabp3 124 19 SM SM NNP cord-294218-v4gjabp3 124 20 , , , cord-294218-v4gjabp3 124 21 but but CC cord-294218-v4gjabp3 124 22 appeared appear VBD cord-294218-v4gjabp3 124 23 slightly slightly RB cord-294218-v4gjabp3 124 24 labeled label VBN cord-294218-v4gjabp3 124 25 with with IN cord-294218-v4gjabp3 124 26 [ [ -LRB- cord-294218-v4gjabp3 124 27 3H]glucosamine 3h]glucosamine NN cord-294218-v4gjabp3 124 28 ( ( -LRB- cord-294218-v4gjabp3 124 29 Fig Fig NNP cord-294218-v4gjabp3 124 30 . . . cord-294218-v4gjabp3 124 31 4A 4a CD cord-294218-v4gjabp3 124 32 , , , cord-294218-v4gjabp3 124 33 lanes lane NNS cord-294218-v4gjabp3 124 34 4 4 CD cord-294218-v4gjabp3 124 35 and and CC cord-294218-v4gjabp3 124 36 6 6 CD cord-294218-v4gjabp3 124 37 ) ) -RRB- cord-294218-v4gjabp3 124 38 . . . cord-294218-v4gjabp3 125 1 Glycosylation glycosylation NN cord-294218-v4gjabp3 125 2 of of IN cord-294218-v4gjabp3 125 3 the the DT cord-294218-v4gjabp3 125 4 matrix matrix NN cord-294218-v4gjabp3 125 5 protein protein NN cord-294218-v4gjabp3 125 6 of of IN cord-294218-v4gjabp3 125 7 TCV TCV NNP cord-294218-v4gjabp3 125 8 was be VBD cord-294218-v4gjabp3 125 9 also also RB cord-294218-v4gjabp3 125 10 affected affect VBN cord-294218-v4gjabp3 125 11 by by IN cord-294218-v4gjabp3 125 12 TM TM NNP cord-294218-v4gjabp3 125 13 . . . cord-294218-v4gjabp3 126 1 Neither neither CC cord-294218-v4gjabp3 126 2 the the DT cord-294218-v4gjabp3 126 3 major major JJ cord-294218-v4gjabp3 126 4 gp24 gp24 NNP cord-294218-v4gjabp3 126 5 , , , cord-294218-v4gjabp3 126 6 nor nor CC cord-294218-v4gjabp3 126 7 the the DT cord-294218-v4gjabp3 126 8 36 36 CD cord-294218-v4gjabp3 126 9 - - SYM cord-294218-v4gjabp3 126 10 38,000 38,000 CD cord-294218-v4gjabp3 126 11 and and CC cord-294218-v4gjabp3 126 12 44,000 44,000 CD cord-294218-v4gjabp3 126 13 mol.wt mol.wt NN cord-294218-v4gjabp3 126 14 , , , cord-294218-v4gjabp3 126 15 species specie NNS cord-294218-v4gjabp3 126 16 could could MD cord-294218-v4gjabp3 126 17 be be VB cord-294218-v4gjabp3 126 18 immunoprecipitated immunoprecipitate VBN cord-294218-v4gjabp3 126 19 after after IN cord-294218-v4gjabp3 126 20 TM TM NNP cord-294218-v4gjabp3 126 21 treatment treatment NN cord-294218-v4gjabp3 126 22 ( ( -LRB- cord-294218-v4gjabp3 126 23 Fig Fig NNP cord-294218-v4gjabp3 126 24 . . . cord-294218-v4gjabp3 126 25 4A 4a CD cord-294218-v4gjabp3 126 26 ) ) -RRB- cord-294218-v4gjabp3 126 27 . . . cord-294218-v4gjabp3 127 1 In in IN cord-294218-v4gjabp3 127 2 contrast contrast NN cord-294218-v4gjabp3 127 3 , , , cord-294218-v4gjabp3 127 4 all all PDT cord-294218-v4gjabp3 127 5 these these DT cord-294218-v4gjabp3 127 6 protein protein NN cord-294218-v4gjabp3 127 7 species specie NNS cord-294218-v4gjabp3 127 8 were be VBD cord-294218-v4gjabp3 127 9 identified identify VBN cord-294218-v4gjabp3 127 10 in in IN cord-294218-v4gjabp3 127 11 immunoprecipitates immunoprecipitate NNS cord-294218-v4gjabp3 127 12 from from IN cord-294218-v4gjabp3 127 13 extracts extract NNS cord-294218-v4gjabp3 127 14 of of IN cord-294218-v4gjabp3 127 15 untreated untreated JJ cord-294218-v4gjabp3 127 16 and and CC cord-294218-v4gjabp3 127 17 SM sm NN cord-294218-v4gjabp3 127 18 - - HYPH cord-294218-v4gjabp3 127 19 treated treat VBN cord-294218-v4gjabp3 127 20 TCV TCV NNP cord-294218-v4gjabp3 127 21 - - HYPH cord-294218-v4gjabp3 127 22 infected infect VBN cord-294218-v4gjabp3 127 23 cells cell NNS cord-294218-v4gjabp3 128 1 ( ( -LRB- cord-294218-v4gjabp3 128 2 Fig Fig NNP cord-294218-v4gjabp3 128 3 . . . cord-294218-v4gjabp3 128 4 4A 4a CD cord-294218-v4gjabp3 128 5 , , , cord-294218-v4gjabp3 128 6 B B NNP cord-294218-v4gjabp3 128 7 ) ) -RRB- cord-294218-v4gjabp3 128 8 . . . cord-294218-v4gjabp3 129 1 The the DT cord-294218-v4gjabp3 129 2 maturation maturation NN cord-294218-v4gjabp3 129 3 of of IN cord-294218-v4gjabp3 129 4 TCV TCV NNP cord-294218-v4gjabp3 129 5 in in IN cord-294218-v4gjabp3 129 6 the the DT cord-294218-v4gjabp3 129 7 absence absence NN cord-294218-v4gjabp3 129 8 or or CC cord-294218-v4gjabp3 129 9 presence presence NN cord-294218-v4gjabp3 129 10 of of IN cord-294218-v4gjabp3 129 11 glycosylation glycosylation NN cord-294218-v4gjabp3 129 12 inhibitors inhibitor NNS cord-294218-v4gjabp3 129 13 was be VBD cord-294218-v4gjabp3 129 14 followed follow VBN cord-294218-v4gjabp3 129 15 by by IN cord-294218-v4gjabp3 129 16 sequential sequential JJ cord-294218-v4gjabp3 129 17 analysis analysis NN cord-294218-v4gjabp3 129 18 by by IN cord-294218-v4gjabp3 129 19 EM EM NNP cord-294218-v4gjabp3 129 20 of of IN cord-294218-v4gjabp3 129 21 ultrathin ultrathin JJ cord-294218-v4gjabp3 129 22 sections section NNS cord-294218-v4gjabp3 129 23 of of IN cord-294218-v4gjabp3 129 24 TCV TCV NNP cord-294218-v4gjabp3 129 25 - - HYPH cord-294218-v4gjabp3 129 26 infected infect VBN cord-294218-v4gjabp3 129 27 cells cell NNS cord-294218-v4gjabp3 129 28 . . . cord-294218-v4gjabp3 130 1 Electron electron NN cord-294218-v4gjabp3 130 2 microscopic microscopic JJ cord-294218-v4gjabp3 130 3 examination examination NN cord-294218-v4gjabp3 130 4 of of IN cord-294218-v4gjabp3 130 5 negatively negatively RB cord-294218-v4gjabp3 130 6 stained stain VBN cord-294218-v4gjabp3 130 7 untreated untreated JJ cord-294218-v4gjabp3 130 8 TCVinfected tcvinfecte VBN cord-294218-v4gjabp3 130 9 cells cell NNS cord-294218-v4gjabp3 130 10 , , , cord-294218-v4gjabp3 130 11 at at IN cord-294218-v4gjabp3 130 12 18 18 CD cord-294218-v4gjabp3 130 13 hours hour NNS cord-294218-v4gjabp3 130 14 after after IN cord-294218-v4gjabp3 130 15 inoculation inoculation NN cord-294218-v4gjabp3 130 16 , , , cord-294218-v4gjabp3 130 17 revealed reveal VBD cord-294218-v4gjabp3 130 18 budding budding NN cord-294218-v4gjabp3 130 19 of of IN cord-294218-v4gjabp3 130 20 coronavirus coronavirus NN cord-294218-v4gjabp3 130 21 particles particle NNS cord-294218-v4gjabp3 130 22 through through IN cord-294218-v4gjabp3 130 23 intracytoplasmic intracytoplasmic JJ cord-294218-v4gjabp3 130 24 membranes membrane NNS cord-294218-v4gjabp3 130 25 and and CC cord-294218-v4gjabp3 130 26 their -PRON- PRP$ cord-294218-v4gjabp3 130 27 accumulation accumulation NN cord-294218-v4gjabp3 130 28 in in IN cord-294218-v4gjabp3 130 29 the the DT cord-294218-v4gjabp3 130 30 lumen lumen NN cord-294218-v4gjabp3 130 31 of of IN cord-294218-v4gjabp3 130 32 smooth smooth JJ cord-294218-v4gjabp3 130 33 - - HYPH cord-294218-v4gjabp3 130 34 walled walled JJ cord-294218-v4gjabp3 130 35 vesicles vesicle NNS cord-294218-v4gjabp3 130 36 ( ( -LRB- cord-294218-v4gjabp3 130 37 Fig Fig NNP cord-294218-v4gjabp3 130 38 . . . cord-294218-v4gjabp3 130 39 5A 5a CD cord-294218-v4gjabp3 130 40 ) ) -RRB- cord-294218-v4gjabp3 130 41 . . . cord-294218-v4gjabp3 131 1 Progeny progeny JJ cord-294218-v4gjabp3 131 2 viral viral JJ cord-294218-v4gjabp3 131 3 particles particle NNS cord-294218-v4gjabp3 131 4 were be VBD cord-294218-v4gjabp3 131 5 shown show VBN cord-294218-v4gjabp3 131 6 at at IN cord-294218-v4gjabp3 131 7 the the DT cord-294218-v4gjabp3 131 8 outer outer JJ cord-294218-v4gjabp3 131 9 surface surface NN cord-294218-v4gjabp3 131 10 of of IN cord-294218-v4gjabp3 131 11 infected infected JJ cord-294218-v4gjabp3 131 12 cells cell NNS cord-294218-v4gjabp3 131 13 , , , cord-294218-v4gjabp3 131 14 but but CC cord-294218-v4gjabp3 131 15 none none NN cord-294218-v4gjabp3 131 16 have have VBP cord-294218-v4gjabp3 131 17 been be VBN cord-294218-v4gjabp3 131 18 observed observe VBN cord-294218-v4gjabp3 131 19 to to TO cord-294218-v4gjabp3 131 20 be be VB cord-294218-v4gjabp3 131 21 budding bud VBG cord-294218-v4gjabp3 131 22 from from IN cord-294218-v4gjabp3 131 23 the the DT cord-294218-v4gjabp3 131 24 plasma plasma NN cord-294218-v4gjabp3 131 25 membrane membrane NN cord-294218-v4gjabp3 131 26 . . . cord-294218-v4gjabp3 132 1 The the DT cord-294218-v4gjabp3 132 2 intracellular intracellular JJ cord-294218-v4gjabp3 132 3 and and CC cord-294218-v4gjabp3 132 4 extracellular extracellular JJ cord-294218-v4gjabp3 132 5 viral viral JJ cord-294218-v4gjabp3 132 6 particles particle NNS cord-294218-v4gjabp3 132 7 were be VBD cord-294218-v4gjabp3 132 8 spherical spherical JJ cord-294218-v4gjabp3 132 9 in in IN cord-294218-v4gjabp3 132 10 shape shape NN cord-294218-v4gjabp3 132 11 with with IN cord-294218-v4gjabp3 132 12 an an DT cord-294218-v4gjabp3 132 13 electron electron NN cord-294218-v4gjabp3 132 14 - - HYPH cord-294218-v4gjabp3 132 15 lucent lucent NN cord-294218-v4gjabp3 132 16 center center NN cord-294218-v4gjabp3 132 17 and and CC cord-294218-v4gjabp3 132 18 possessed possess VBD cord-294218-v4gjabp3 132 19 large large JJ cord-294218-v4gjabp3 132 20 bulbous bulbous JJ cord-294218-v4gjabp3 132 21 surface surface NN cord-294218-v4gjabp3 132 22 projections projection NNS cord-294218-v4gjabp3 132 23 ( ( -LRB- cord-294218-v4gjabp3 132 24 Fig fig NN cord-294218-v4gjabp3 132 25 . . . cord-294218-v4gjabp3 132 26 5 5 CD cord-294218-v4gjabp3 132 27 B b NN cord-294218-v4gjabp3 132 28 ) ) -RRB- cord-294218-v4gjabp3 132 29 . . . cord-294218-v4gjabp3 133 1 The the DT cord-294218-v4gjabp3 133 2 formation formation NN cord-294218-v4gjabp3 133 3 ofvirions ofvirions NN cord-294218-v4gjabp3 133 4 was be VBD cord-294218-v4gjabp3 133 5 not not RB cord-294218-v4gjabp3 133 6 inhibited inhibit VBN cord-294218-v4gjabp3 133 7 by by IN cord-294218-v4gjabp3 133 8 0.1 0.1 CD cord-294218-v4gjabp3 133 9 to to TO cord-294218-v4gjabp3 133 10 1.0 1.0 CD cord-294218-v4gjabp3 133 11 gg gg NNS cord-294218-v4gjabp3 133 12 / / , cord-294218-v4gjabp3 133 13 ml ml NN cord-294218-v4gjabp3 133 14 of of IN cord-294218-v4gjabp3 133 15 TM TM NNP cord-294218-v4gjabp3 133 16 ( ( -LRB- cord-294218-v4gjabp3 133 17 Fig Fig NNP cord-294218-v4gjabp3 133 18 . . . cord-294218-v4gjabp3 133 19 6 6 CD cord-294218-v4gjabp3 133 20 ) ) -RRB- cord-294218-v4gjabp3 133 21 . . . cord-294218-v4gjabp3 134 1 Complete complete JJ cord-294218-v4gjabp3 134 2 virions virion NNS cord-294218-v4gjabp3 134 3 were be VBD cord-294218-v4gjabp3 134 4 observed observe VBN cord-294218-v4gjabp3 134 5 in in IN cord-294218-v4gjabp3 134 6 dilated dilated JJ cord-294218-v4gjabp3 134 7 cytoplasmic cytoplasmic JJ cord-294218-v4gjabp3 134 8 vacuoles vacuole NNS cord-294218-v4gjabp3 134 9 , , , cord-294218-v4gjabp3 134 10 but but CC cord-294218-v4gjabp3 134 11 there there EX cord-294218-v4gjabp3 134 12 was be VBD cord-294218-v4gjabp3 134 13 also also RB cord-294218-v4gjabp3 134 14 an an DT cord-294218-v4gjabp3 134 15 important important JJ cord-294218-v4gjabp3 134 16 accumulation accumulation NN cord-294218-v4gjabp3 134 17 of of IN cord-294218-v4gjabp3 134 18 amorphous amorphous JJ cord-294218-v4gjabp3 134 19 material material NN cord-294218-v4gjabp3 134 20 , , , cord-294218-v4gjabp3 134 21 suggesting suggest VBG cord-294218-v4gjabp3 134 22 at at IN cord-294218-v4gjabp3 134 23 least least JJS cord-294218-v4gjabp3 134 24 a a DT cord-294218-v4gjabp3 134 25 partial partial JJ cord-294218-v4gjabp3 134 26 interference interference NN cord-294218-v4gjabp3 134 27 with with IN cord-294218-v4gjabp3 134 28 the the DT cord-294218-v4gjabp3 134 29 viral viral JJ cord-294218-v4gjabp3 134 30 assembly assembly NN cord-294218-v4gjabp3 134 31 ( ( -LRB- cord-294218-v4gjabp3 134 32 Fig Fig NNP cord-294218-v4gjabp3 134 33 . . . cord-294218-v4gjabp3 134 34 6A 6a CD cord-294218-v4gjabp3 134 35 ) ) -RRB- cord-294218-v4gjabp3 134 36 . . . cord-294218-v4gjabp3 135 1 Virions virion NNS cord-294218-v4gjabp3 135 2 that that WDT cord-294218-v4gjabp3 135 3 were be VBD cord-294218-v4gjabp3 135 4 present present JJ cord-294218-v4gjabp3 135 5 in in IN cord-294218-v4gjabp3 135 6 the the DT cord-294218-v4gjabp3 135 7 cytoplasmic cytoplasmic JJ cord-294218-v4gjabp3 135 8 vacuoles vacuole NNS cord-294218-v4gjabp3 135 9 migrating migrate VBG cord-294218-v4gjabp3 135 10 to to IN cord-294218-v4gjabp3 135 11 the the DT cord-294218-v4gjabp3 135 12 cell cell NN cord-294218-v4gjabp3 135 13 surface surface NN cord-294218-v4gjabp3 135 14 apparently apparently RB cord-294218-v4gjabp3 135 15 lacked lack VBD cord-294218-v4gjabp3 135 16 the the DT cord-294218-v4gjabp3 135 17 characteristic characteristic JJ cord-294218-v4gjabp3 135 18 large large JJ cord-294218-v4gjabp3 135 19 peplomers peplomer NNS cord-294218-v4gjabp3 135 20 of of IN cord-294218-v4gjabp3 135 21 coronaviruses coronaviruse NNS cord-294218-v4gjabp3 135 22 ( ( -LRB- cord-294218-v4gjabp3 135 23 Fig Fig NNP cord-294218-v4gjabp3 135 24 . . . cord-294218-v4gjabp3 135 25 6 6 CD cord-294218-v4gjabp3 135 26 B b NN cord-294218-v4gjabp3 135 27 ) ) -RRB- cord-294218-v4gjabp3 135 28 . . . cord-294218-v4gjabp3 136 1 The the DT cord-294218-v4gjabp3 136 2 virions virion NNS cord-294218-v4gjabp3 136 3 were be VBD cord-294218-v4gjabp3 136 4 released release VBN cord-294218-v4gjabp3 136 5 from from IN cord-294218-v4gjabp3 136 6 TM TM NNP cord-294218-v4gjabp3 136 7 - - HYPH cord-294218-v4gjabp3 136 8 treated treat VBN cord-294218-v4gjabp3 136 9 cells cell NNS cord-294218-v4gjabp3 136 10 , , , cord-294218-v4gjabp3 136 11 but but CC cord-294218-v4gjabp3 136 12 usually usually RB cord-294218-v4gjabp3 136 13 none none NN cord-294218-v4gjabp3 136 14 were be VBD cord-294218-v4gjabp3 136 15 adsorbed adsorb VBN cord-294218-v4gjabp3 136 16 to to IN cord-294218-v4gjabp3 136 17 the the DT cord-294218-v4gjabp3 136 18 plasma plasma NN cord-294218-v4gjabp3 136 19 membrane membrane NN cord-294218-v4gjabp3 136 20 . . . cord-294218-v4gjabp3 137 1 The the DT cord-294218-v4gjabp3 137 2 addition addition NN cord-294218-v4gjabp3 137 3 of of IN cord-294218-v4gjabp3 137 4 SM sm NN cord-294218-v4gjabp3 137 5 to to IN cord-294218-v4gjabp3 137 6 the the DT cord-294218-v4gjabp3 137 7 medium medium NN cord-294218-v4gjabp3 137 8 of of IN cord-294218-v4gjabp3 137 9 TCV TCV NNP cord-294218-v4gjabp3 137 10 - - HYPH cord-294218-v4gjabp3 137 11 infected infect VBN cord-294218-v4gjabp3 137 12 cell cell NN cord-294218-v4gjabp3 137 13 cultures culture NNS cord-294218-v4gjabp3 137 14 did do VBD cord-294218-v4gjabp3 137 15 not not RB cord-294218-v4gjabp3 137 16 interfere interfere VB cord-294218-v4gjabp3 137 17 with with IN cord-294218-v4gjabp3 137 18 the the DT cord-294218-v4gjabp3 137 19 normal normal JJ cord-294218-v4gjabp3 137 20 maturation maturation NN cord-294218-v4gjabp3 137 21 of of IN cord-294218-v4gjabp3 137 22 the the DT cord-294218-v4gjabp3 137 23 virus virus NN cord-294218-v4gjabp3 137 24 ( ( -LRB- cord-294218-v4gjabp3 137 25 Fig Fig NNP cord-294218-v4gjabp3 137 26 . . NNP cord-294218-v4gjabp3 137 27 7 7 CD cord-294218-v4gjabp3 137 28 ) ) -RRB- cord-294218-v4gjabp3 137 29 . . . cord-294218-v4gjabp3 138 1 Large large JJ cord-294218-v4gjabp3 138 2 numbers number NNS cord-294218-v4gjabp3 138 3 of of IN cord-294218-v4gjabp3 138 4 progeny progeny JJ cord-294218-v4gjabp3 138 5 viral viral JJ cord-294218-v4gjabp3 138 6 particles particle NNS cord-294218-v4gjabp3 138 7 could could MD cord-294218-v4gjabp3 138 8 be be VB cord-294218-v4gjabp3 138 9 observed observe VBN cord-294218-v4gjabp3 138 10 in in IN cord-294218-v4gjabp3 138 11 the the DT cord-294218-v4gjabp3 138 12 cytosol cytosol NN cord-294218-v4gjabp3 138 13 even even RB cord-294218-v4gjabp3 138 14 at at IN cord-294218-v4gjabp3 138 15 a a DT cord-294218-v4gjabp3 138 16 SM sm NN cord-294218-v4gjabp3 138 17 concentration concentration NN cord-294218-v4gjabp3 138 18 of of IN cord-294218-v4gjabp3 138 19 5 5 CD cord-294218-v4gjabp3 138 20 gM gm NN cord-294218-v4gjabp3 138 21 / / SYM cord-294218-v4gjabp3 138 22 ml ml NN cord-294218-v4gjabp3 138 23 . . . cord-294218-v4gjabp3 139 1 However however RB cord-294218-v4gjabp3 139 2 , , , cord-294218-v4gjabp3 139 3 such such JJ cord-294218-v4gjabp3 139 4 high high JJ cord-294218-v4gjabp3 139 5 concentration concentration NN cord-294218-v4gjabp3 139 6 of of IN cord-294218-v4gjabp3 139 7 SM SM NNP cord-294218-v4gjabp3 139 8 seemed seem VBD cord-294218-v4gjabp3 139 9 to to TO cord-294218-v4gjabp3 139 10 be be VB cord-294218-v4gjabp3 139 11 very very RB cord-294218-v4gjabp3 139 12 toxic toxic JJ cord-294218-v4gjabp3 139 13 for for IN cord-294218-v4gjabp3 139 14 HRT-18 HRT-18 NNP cord-294218-v4gjabp3 139 15 cells cell NNS cord-294218-v4gjabp3 139 16 , , , cord-294218-v4gjabp3 139 17 as as IN cord-294218-v4gjabp3 139 18 suggested suggest VBN cord-294218-v4gjabp3 139 19 by by IN cord-294218-v4gjabp3 139 20 the the DT cord-294218-v4gjabp3 139 21 intensive intensive JJ cord-294218-v4gjabp3 139 22 vacuolisation vacuolisation NN cord-294218-v4gjabp3 139 23 ( ( -LRB- cord-294218-v4gjabp3 139 24 Fig Fig NNP cord-294218-v4gjabp3 139 25 . . . cord-294218-v4gjabp3 139 26 7 7 CD cord-294218-v4gjabp3 139 27 B b NN cord-294218-v4gjabp3 139 28 ) ) -RRB- cord-294218-v4gjabp3 139 29 . . . cord-294218-v4gjabp3 140 1 The the DT cord-294218-v4gjabp3 140 2 viral viral JJ cord-294218-v4gjabp3 140 3 particles particle NNS cord-294218-v4gjabp3 140 4 that that WDT cord-294218-v4gjabp3 140 5 accumulated accumulate VBN cord-294218-v4gjabp3 140 6 in in IN cord-294218-v4gjabp3 140 7 the the DT cord-294218-v4gjabp3 140 8 lumen lumen NN cord-294218-v4gjabp3 140 9 of of IN cord-294218-v4gjabp3 140 10 smooth smooth JJ cord-294218-v4gjabp3 140 11 - - HYPH cord-294218-v4gjabp3 140 12 walled walled JJ cord-294218-v4gjabp3 140 13 vesicles vesicle NNS cord-294218-v4gjabp3 140 14 of of IN cord-294218-v4gjabp3 140 15 ( ( -LRB- cord-294218-v4gjabp3 140 16 Fig Fig NNP cord-294218-v4gjabp3 140 17 . . . cord-294218-v4gjabp3 140 18 7A 7a NN cord-294218-v4gjabp3 140 19 ) ) -RRB- cord-294218-v4gjabp3 140 20 . . . cord-294218-v4gjabp3 141 1 N N NNP cord-294218-v4gjabp3 141 2 u u NN cord-294218-v4gjabp3 141 3 m m NN cord-294218-v4gjabp3 141 4 e e NN cord-294218-v4gjabp3 141 5 r r NN cord-294218-v4gjabp3 141 6 o o NN cord-294218-v4gjabp3 141 7 u u NN cord-294218-v4gjabp3 141 8 s s NNP cord-294218-v4gjabp3 141 9 viral viral JJ cord-294218-v4gjabp3 141 10 particles particle NNS cord-294218-v4gjabp3 141 11 were be VBD cord-294218-v4gjabp3 141 12 observed observe VBN cord-294218-v4gjabp3 141 13 in in IN cord-294218-v4gjabp3 141 14 the the DT cord-294218-v4gjabp3 141 15 intercellular intercellular JJ cord-294218-v4gjabp3 141 16 spaces space NNS cord-294218-v4gjabp3 141 17 and and CC cord-294218-v4gjabp3 141 18 , , , cord-294218-v4gjabp3 141 19 m m NNP cord-294218-v4gjabp3 141 20 a a NNP cord-294218-v4gjabp3 141 21 n n NNP cord-294218-v4gjabp3 141 22 y y NNP cord-294218-v4gjabp3 141 23 were be VBD cord-294218-v4gjabp3 141 24 adsorbed adsorb VBN cord-294218-v4gjabp3 141 25 to to IN cord-294218-v4gjabp3 141 26 the the DT cord-294218-v4gjabp3 141 27 plasma plasma NN cord-294218-v4gjabp3 141 28 membrane membrane NN cord-294218-v4gjabp3 141 29 . . . cord-294218-v4gjabp3 142 1 These these DT cord-294218-v4gjabp3 142 2 virions virion NNS cord-294218-v4gjabp3 142 3 possessed possess VBD cord-294218-v4gjabp3 142 4 the the DT cord-294218-v4gjabp3 142 5 characteristic characteristic JJ cord-294218-v4gjabp3 142 6 surface surface NN cord-294218-v4gjabp3 142 7 peplomers peplomer NNS cord-294218-v4gjabp3 142 8 . . . cord-294218-v4gjabp3 143 1 Long long JJ cord-294218-v4gjabp3 143 2 tubules tubule NNS cord-294218-v4gjabp3 143 3 , , , cord-294218-v4gjabp3 143 4 25 25 CD cord-294218-v4gjabp3 143 5 to to TO cord-294218-v4gjabp3 143 6 3 3 CD cord-294218-v4gjabp3 143 7 0 0 CD cord-294218-v4gjabp3 143 8 n n NN cord-294218-v4gjabp3 143 9 m m NN cord-294218-v4gjabp3 143 10 in in IN cord-294218-v4gjabp3 143 11 diameter diameter NN cord-294218-v4gjabp3 143 12 , , , cord-294218-v4gjabp3 143 13 accumulated accumulate VBN cord-294218-v4gjabp3 143 14 in in IN cord-294218-v4gjabp3 143 15 dilated dilated JJ cord-294218-v4gjabp3 143 16 cysternae cysternae NN cord-294218-v4gjabp3 143 17 or or CC cord-294218-v4gjabp3 143 18 in in IN cord-294218-v4gjabp3 143 19 cytoplasmic cytoplasmic JJ cord-294218-v4gjabp3 143 20 vacuoles vacuole NNS cord-294218-v4gjabp3 143 21 ( ( -LRB- cord-294218-v4gjabp3 143 22 Fig Fig NNP cord-294218-v4gjabp3 143 23 . . . cord-294218-v4gjabp3 143 24 7 7 CD cord-294218-v4gjabp3 143 25 B b NN cord-294218-v4gjabp3 143 26 ) ) -RRB- cord-294218-v4gjabp3 143 27 . . . cord-294218-v4gjabp3 144 1 Previous previous JJ cord-294218-v4gjabp3 144 2 studies study NNS cord-294218-v4gjabp3 144 3 on on IN cord-294218-v4gjabp3 144 4 the the DT cord-294218-v4gjabp3 144 5 structural structural JJ cord-294218-v4gjabp3 144 6 proteins protein NNS cord-294218-v4gjabp3 144 7 of of IN cord-294218-v4gjabp3 144 8 the the DT cord-294218-v4gjabp3 144 9 TCV TCV NNP cord-294218-v4gjabp3 144 10 virions virion NNS cord-294218-v4gjabp3 144 11 , , , cord-294218-v4gjabp3 144 12 produced produce VBN cord-294218-v4gjabp3 144 13 in in IN cord-294218-v4gjabp3 144 14 cell cell NN cord-294218-v4gjabp3 144 15 cultures culture NNS cord-294218-v4gjabp3 144 16 or or CC cord-294218-v4gjabp3 144 17 in in IN cord-294218-v4gjabp3 144 18 ovo ovo NNP cord-294218-v4gjabp3 144 19 , , , cord-294218-v4gjabp3 144 20 have have VBP cord-294218-v4gjabp3 144 21 revealed reveal VBN cord-294218-v4gjabp3 144 22 a a DT cord-294218-v4gjabp3 144 23 polypeptide polypeptide NN cord-294218-v4gjabp3 144 24 pattern pattern NN cord-294218-v4gjabp3 144 25 described describe VBN cord-294218-v4gjabp3 144 26 so so RB cord-294218-v4gjabp3 144 27 far far RB cord-294218-v4gjabp3 144 28 only only RB cord-294218-v4gjabp3 144 29 for for IN cord-294218-v4gjabp3 144 30 viruses virus NNS cord-294218-v4gjabp3 144 31 belonging belong VBG cord-294218-v4gjabp3 144 32 to to IN cord-294218-v4gjabp3 144 33 the the DT cord-294218-v4gjabp3 144 34 subgroup subgroup NN cord-294218-v4gjabp3 144 35 of of IN cord-294218-v4gjabp3 144 36 mammalian mammalian JJ cord-294218-v4gjabp3 144 37 hemagglutinating hemagglutinating NNP cord-294218-v4gjabp3 144 38 coronaviruses coronaviruse NNS cord-294218-v4gjabp3 144 39 [ [ -LRB- cord-294218-v4gjabp3 144 40 6 6 CD cord-294218-v4gjabp3 144 41 ] ] -RRB- cord-294218-v4gjabp3 144 42 . . . cord-294218-v4gjabp3 145 1 In in IN cord-294218-v4gjabp3 145 2 addition addition NN cord-294218-v4gjabp3 145 3 to to IN cord-294218-v4gjabp3 145 4 the the DT cord-294218-v4gjabp3 145 5 peplomeric peplomeric JJ cord-294218-v4gjabp3 145 6 and and CC cord-294218-v4gjabp3 145 7 matrix matrix NN cord-294218-v4gjabp3 145 8 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 145 9 , , , cord-294218-v4gjabp3 145 10 TCV TCV NNP cord-294218-v4gjabp3 145 11 virions virion NNS cord-294218-v4gjabp3 145 12 contain contain VBP cord-294218-v4gjabp3 145 13 an an DT cord-294218-v4gjabp3 145 14 envelope envelope NN cord-294218-v4gjabp3 145 15 glycoprotein glycoprotein NN cord-294218-v4gjabp3 145 16 , , , cord-294218-v4gjabp3 145 17 having have VBG cord-294218-v4gjabp3 145 18 a a DT cord-294218-v4gjabp3 145 19 mol.wt mol.wt NNP cord-294218-v4gjabp3 145 20 , , , cord-294218-v4gjabp3 145 21 of of IN cord-294218-v4gjabp3 145 22 140,000 140,000 CD cord-294218-v4gjabp3 145 23 , , , cord-294218-v4gjabp3 145 24 which which WDT cord-294218-v4gjabp3 145 25 behaves behave VBZ cord-294218-v4gjabp3 145 26 as as IN cord-294218-v4gjabp3 145 27 a a DT cord-294218-v4gjabp3 145 28 disulfide disulfide RB cord-294218-v4gjabp3 145 29 - - HYPH cord-294218-v4gjabp3 145 30 linked link VBN cord-294218-v4gjabp3 145 31 dimer dimer NN cord-294218-v4gjabp3 145 32 of of IN cord-294218-v4gjabp3 145 33 60 60 CD cord-294218-v4gjabp3 145 34 - - SYM cord-294218-v4gjabp3 145 35 65,000 65,000 CD cord-294218-v4gjabp3 145 36 subunits subunit NNS cord-294218-v4gjabp3 145 37 , , , cord-294218-v4gjabp3 145 38 and and CC cord-294218-v4gjabp3 145 39 which which WDT cord-294218-v4gjabp3 145 40 has have VBZ cord-294218-v4gjabp3 145 41 been be VBN cord-294218-v4gjabp3 145 42 associated associate VBN cord-294218-v4gjabp3 145 43 to to IN cord-294218-v4gjabp3 145 44 the the DT cord-294218-v4gjabp3 145 45 hemagglutinin hemagglutinin NN cord-294218-v4gjabp3 145 46 ( ( -LRB- cord-294218-v4gjabp3 145 47 accompanying accompany VBG cord-294218-v4gjabp3 145 48 paper paper NN cord-294218-v4gjabp3 145 49 ) ) -RRB- cord-294218-v4gjabp3 145 50 . . . cord-294218-v4gjabp3 146 1 In in IN cord-294218-v4gjabp3 146 2 this this DT cord-294218-v4gjabp3 146 3 paper paper NN cord-294218-v4gjabp3 146 4 , , , cord-294218-v4gjabp3 146 5 we -PRON- PRP cord-294218-v4gjabp3 146 6 described describe VBD cord-294218-v4gjabp3 146 7 the the DT cord-294218-v4gjabp3 146 8 identification identification NN cord-294218-v4gjabp3 146 9 of of IN cord-294218-v4gjabp3 146 10 virus virus NN cord-294218-v4gjabp3 146 11 - - HYPH cord-294218-v4gjabp3 146 12 induced induce VBN cord-294218-v4gjabp3 146 13 intracellular intracellular JJ cord-294218-v4gjabp3 146 14 polypeptides polypeptide NNS cord-294218-v4gjabp3 146 15 in in IN cord-294218-v4gjabp3 146 16 TCV TCV NNP cord-294218-v4gjabp3 146 17 - - HYPH cord-294218-v4gjabp3 146 18 infected infect VBN cord-294218-v4gjabp3 146 19 HRT-18 HRT-18 NNP cord-294218-v4gjabp3 146 20 cells cell NNS cord-294218-v4gjabp3 146 21 , , , cord-294218-v4gjabp3 146 22 the the DT cord-294218-v4gjabp3 146 23 kinetic kinetic NN cord-294218-v4gjabp3 146 24 of of IN cord-294218-v4gjabp3 146 25 their -PRON- PRP$ cord-294218-v4gjabp3 146 26 synthesis synthesis NN cord-294218-v4gjabp3 146 27 , , , cord-294218-v4gjabp3 146 28 their -PRON- PRP$ cord-294218-v4gjabp3 146 29 post post JJ cord-294218-v4gjabp3 146 30 - - JJ cord-294218-v4gjabp3 146 31 translational translational JJ cord-294218-v4gjabp3 146 32 processing processing NN cord-294218-v4gjabp3 146 33 in in IN cord-294218-v4gjabp3 146 34 the the DT cord-294218-v4gjabp3 146 35 presence presence NN cord-294218-v4gjabp3 146 36 of of IN cord-294218-v4gjabp3 146 37 glycosylation glycosylation NN cord-294218-v4gjabp3 146 38 inhibitors inhibitor NNS cord-294218-v4gjabp3 146 39 and and CC cord-294218-v4gjabp3 146 40 their -PRON- PRP$ cord-294218-v4gjabp3 146 41 significance significance NN cord-294218-v4gjabp3 146 42 with with IN cord-294218-v4gjabp3 146 43 respect respect NN cord-294218-v4gjabp3 146 44 to to IN cord-294218-v4gjabp3 146 45 the the DT cord-294218-v4gjabp3 146 46 production production NN cord-294218-v4gjabp3 146 47 of of IN cord-294218-v4gjabp3 146 48 mature mature JJ cord-294218-v4gjabp3 146 49 virions virion NNS cord-294218-v4gjabp3 146 50 . . . cord-294218-v4gjabp3 147 1 We -PRON- PRP cord-294218-v4gjabp3 147 2 found find VBD cord-294218-v4gjabp3 147 3 that that IN cord-294218-v4gjabp3 147 4 TCV TCV NNP cord-294218-v4gjabp3 147 5 had have VBD cord-294218-v4gjabp3 147 6 a a DT cord-294218-v4gjabp3 147 7 modest modest JJ cord-294218-v4gjabp3 147 8 inhibitory inhibitory JJ cord-294218-v4gjabp3 147 9 effect effect NN cord-294218-v4gjabp3 147 10 on on IN cord-294218-v4gjabp3 147 11 cell cell NN cord-294218-v4gjabp3 147 12 protein protein NN cord-294218-v4gjabp3 147 13 synthesis synthesis NN cord-294218-v4gjabp3 147 14 , , , cord-294218-v4gjabp3 147 15 making make VBG cord-294218-v4gjabp3 147 16 the the DT cord-294218-v4gjabp3 147 17 analysis analysis NN cord-294218-v4gjabp3 147 18 of of IN cord-294218-v4gjabp3 147 19 virus virus NN cord-294218-v4gjabp3 147 20 - - HYPH cord-294218-v4gjabp3 147 21 specific specific JJ cord-294218-v4gjabp3 147 22 proteins protein NNS cord-294218-v4gjabp3 147 23 difficult difficult JJ cord-294218-v4gjabp3 147 24 . . . cord-294218-v4gjabp3 148 1 Nevertheless nevertheless RB cord-294218-v4gjabp3 148 2 , , , cord-294218-v4gjabp3 148 3 new new JJ cord-294218-v4gjabp3 148 4 intracellular intracellular JJ cord-294218-v4gjabp3 148 5 protein protein NN cord-294218-v4gjabp3 148 6 species specie NNS cord-294218-v4gjabp3 148 7 could could MD cord-294218-v4gjabp3 148 8 be be VB cord-294218-v4gjabp3 148 9 detected detect VBN cord-294218-v4gjabp3 148 10 as as RB cord-294218-v4gjabp3 148 11 soon soon RB cord-294218-v4gjabp3 148 12 as as IN cord-294218-v4gjabp3 148 13 6 6 CD cord-294218-v4gjabp3 148 14 h h NN cord-294218-v4gjabp3 148 15 post post NN cord-294218-v4gjabp3 148 16 - - NN cord-294218-v4gjabp3 148 17 infection infection NN cord-294218-v4gjabp3 148 18 either either CC cord-294218-v4gjabp3 148 19 by by IN cord-294218-v4gjabp3 148 20 SDS SDS NNP cord-294218-v4gjabp3 148 21 - - HYPH cord-294218-v4gjabp3 148 22 PAGE PAGE NNP cord-294218-v4gjabp3 148 23 analysis analysis NN cord-294218-v4gjabp3 148 24 of of IN cord-294218-v4gjabp3 148 25 pulse pulse NN cord-294218-v4gjabp3 148 26 - - HYPH cord-294218-v4gjabp3 148 27 labeled label VBN cord-294218-v4gjabp3 148 28 TCV tcv NN cord-294218-v4gjabp3 148 29 - - HYPH cord-294218-v4gjabp3 148 30 infected infect VBN cord-294218-v4gjabp3 148 31 cell cell NN cord-294218-v4gjabp3 148 32 extracts extract NNS cord-294218-v4gjabp3 148 33 or or CC cord-294218-v4gjabp3 148 34 by by IN cord-294218-v4gjabp3 148 35 Western Western NNP cord-294218-v4gjabp3 148 36 - - HYPH cord-294218-v4gjabp3 148 37 immunoblotting immunoblotting NN cord-294218-v4gjabp3 148 38 , , , cord-294218-v4gjabp3 148 39 using use VBG cord-294218-v4gjabp3 148 40 anti anti JJ cord-294218-v4gjabp3 148 41 - - JJ cord-294218-v4gjabp3 148 42 TCV tcv JJ cord-294218-v4gjabp3 148 43 hyperimmune hyperimmune NNP cord-294218-v4gjabp3 148 44 serum serum NN cord-294218-v4gjabp3 148 45 produced produce VBN cord-294218-v4gjabp3 148 46 to to IN cord-294218-v4gjabp3 148 47 the the DT cord-294218-v4gjabp3 148 48 eggadapted eggadapted JJ cord-294218-v4gjabp3 148 49 Minnesota Minnesota NNP cord-294218-v4gjabp3 148 50 strain strain NN cord-294218-v4gjabp3 148 51 . . . cord-294218-v4gjabp3 149 1 The the DT cord-294218-v4gjabp3 149 2 TCV TCV NNP cord-294218-v4gjabp3 149 3 structural structural JJ cord-294218-v4gjabp3 149 4 proteins protein NNS cord-294218-v4gjabp3 149 5 were be VBD cord-294218-v4gjabp3 149 6 all all DT cord-294218-v4gjabp3 149 7 detected detect VBN cord-294218-v4gjabp3 149 8 by by IN cord-294218-v4gjabp3 149 9 9 9 CD cord-294218-v4gjabp3 149 10 h h NN cord-294218-v4gjabp3 149 11 post post NN cord-294218-v4gjabp3 149 12 - - NN cord-294218-v4gjabp3 149 13 infection infection NN cord-294218-v4gjabp3 149 14 , , , cord-294218-v4gjabp3 149 15 in in IN cord-294218-v4gjabp3 149 16 agreement agreement NN cord-294218-v4gjabp3 149 17 with with IN cord-294218-v4gjabp3 149 18 the the DT cord-294218-v4gjabp3 149 19 one one CD cord-294218-v4gjabp3 149 20 - - HYPH cord-294218-v4gjabp3 149 21 step step NN cord-294218-v4gjabp3 149 22 growth growth NN cord-294218-v4gjabp3 149 23 curve curve NN cord-294218-v4gjabp3 149 24 that that WDT cord-294218-v4gjabp3 149 25 was be VBD cord-294218-v4gjabp3 149 26 determined determine VBN cord-294218-v4gjabp3 149 27 in in IN cord-294218-v4gjabp3 149 28 a a DT cord-294218-v4gjabp3 149 29 previous previous JJ cord-294218-v4gjabp3 149 30 study study NN cord-294218-v4gjabp3 149 31 [ [ -LRB- cord-294218-v4gjabp3 149 32 7 7 CD cord-294218-v4gjabp3 149 33 ] ] -RRB- cord-294218-v4gjabp3 149 34 and and CC cord-294218-v4gjabp3 149 35 the the DT cord-294218-v4gjabp3 149 36 replication replication NN cord-294218-v4gjabp3 149 37 cycle cycle NN cord-294218-v4gjabp3 149 38 of of IN cord-294218-v4gjabp3 149 39 coronaviruses coronaviruse NNS cord-294218-v4gjabp3 149 40 [ [ -LRB- cord-294218-v4gjabp3 149 41 40 40 CD cord-294218-v4gjabp3 149 42 ] ] -RRB- cord-294218-v4gjabp3 149 43 . . . cord-294218-v4gjabp3 150 1 At at RB cord-294218-v4gjabp3 150 2 least least RBS cord-294218-v4gjabp3 150 3 12 12 CD cord-294218-v4gjabp3 150 4 to to TO cord-294218-v4gjabp3 150 5 14 14 CD cord-294218-v4gjabp3 150 6 polypeptides polypeptide NNS cord-294218-v4gjabp3 150 7 immunoprecipitated immunoprecipitate VBN cord-294218-v4gjabp3 150 8 from from IN cord-294218-v4gjabp3 150 9 lysates lysate NNS cord-294218-v4gjabp3 150 10 of of IN cord-294218-v4gjabp3 150 11 TCVinfected tcvinfecte VBN cord-294218-v4gjabp3 150 12 cells cell NNS cord-294218-v4gjabp3 150 13 . . . cord-294218-v4gjabp3 151 1 Six six CD cord-294218-v4gjabp3 151 2 of of IN cord-294218-v4gjabp3 151 3 these these DT cord-294218-v4gjabp3 151 4 polypeptides polypeptide NNS cord-294218-v4gjabp3 151 5 , , , cord-294218-v4gjabp3 151 6 with with IN cord-294218-v4gjabp3 151 7 approximate approximate JJ cord-294218-v4gjabp3 151 8 mol.wts mol.wt NNS cord-294218-v4gjabp3 151 9 , , , cord-294218-v4gjabp3 151 10 of of IN cord-294218-v4gjabp3 151 11 t t NNP cord-294218-v4gjabp3 151 12 50 50 CD cord-294218-v4gjabp3 151 13 - - SYM cord-294218-v4gjabp3 151 14 170,000 170,000 CD cord-294218-v4gjabp3 151 15 , , , cord-294218-v4gjabp3 151 16 130,000 130,000 CD cord-294218-v4gjabp3 151 17 , , , cord-294218-v4gjabp3 151 18 90,000 90,000 CD cord-294218-v4gjabp3 151 19 , , , cord-294218-v4gjabp3 151 20 48,000 48,000 CD cord-294218-v4gjabp3 151 21 , , , cord-294218-v4gjabp3 151 22 46,000 46,000 CD cord-294218-v4gjabp3 151 23 , , , cord-294218-v4gjabp3 151 24 and and CC cord-294218-v4gjabp3 151 25 30 30 CD cord-294218-v4gjabp3 151 26 - - SYM cord-294218-v4gjabp3 151 27 32,000 32,000 CD cord-294218-v4gjabp3 151 28 , , , cord-294218-v4gjabp3 151 29 did do VBD cord-294218-v4gjabp3 151 30 not not RB cord-294218-v4gjabp3 151 31 co co VB cord-294218-v4gjabp3 151 32 - - VB cord-294218-v4gjabp3 151 33 migrate migrate VB cord-294218-v4gjabp3 151 34 with with IN cord-294218-v4gjabp3 151 35 virion virion NN cord-294218-v4gjabp3 151 36 proteins protein NNS cord-294218-v4gjabp3 151 37 . . . cord-294218-v4gjabp3 152 1 Although although IN cord-294218-v4gjabp3 152 2 a a DT cord-294218-v4gjabp3 152 3 definitive definitive JJ cord-294218-v4gjabp3 152 4 relationship relationship NN cord-294218-v4gjabp3 152 5 could could MD cord-294218-v4gjabp3 152 6 not not RB cord-294218-v4gjabp3 152 7 be be VB cord-294218-v4gjabp3 152 8 established establish VBN cord-294218-v4gjabp3 152 9 among among IN cord-294218-v4gjabp3 152 10 these these DT cord-294218-v4gjabp3 152 11 various various JJ cord-294218-v4gjabp3 152 12 intracellular intracellular JJ cord-294218-v4gjabp3 152 13 polypeptides polypeptide NNS cord-294218-v4gjabp3 152 14 , , , cord-294218-v4gjabp3 152 15 pulse pulse NN cord-294218-v4gjabp3 152 16 - - HYPH cord-294218-v4gjabp3 152 17 chased chase VBN cord-294218-v4gjabp3 152 18 experiments experiment NNS cord-294218-v4gjabp3 152 19 and and CC cord-294218-v4gjabp3 152 20 analysis analysis NN cord-294218-v4gjabp3 152 21 of of IN cord-294218-v4gjabp3 152 22 infected infected JJ cord-294218-v4gjabp3 152 23 cell cell NN cord-294218-v4gjabp3 152 24 extracts extract NNS cord-294218-v4gjabp3 152 25 after after IN cord-294218-v4gjabp3 152 26 cultivation cultivation NN cord-294218-v4gjabp3 152 27 in in IN cord-294218-v4gjabp3 152 28 the the DT cord-294218-v4gjabp3 152 29 presence presence NN cord-294218-v4gjabp3 152 30 of of IN cord-294218-v4gjabp3 152 31 glycosylation glycosylation NN cord-294218-v4gjabp3 152 32 inhibitors inhibitor NNS cord-294218-v4gjabp3 152 33 suggested suggest VBD cord-294218-v4gjabp3 152 34 that that IN cord-294218-v4gjabp3 152 35 some some DT cord-294218-v4gjabp3 152 36 of of IN cord-294218-v4gjabp3 152 37 these these DT cord-294218-v4gjabp3 152 38 products product NNS cord-294218-v4gjabp3 152 39 correspond correspond VBP cord-294218-v4gjabp3 152 40 to to IN cord-294218-v4gjabp3 152 41 intracellular intracellular JJ cord-294218-v4gjabp3 152 42 precursors precursor NNS cord-294218-v4gjabp3 152 43 , , , cord-294218-v4gjabp3 152 44 cleavage cleavage NN cord-294218-v4gjabp3 152 45 products product NNS cord-294218-v4gjabp3 152 46 or or CC cord-294218-v4gjabp3 152 47 aggregated aggregate VBN cord-294218-v4gjabp3 152 48 forms form NNS cord-294218-v4gjabp3 152 49 of of IN cord-294218-v4gjabp3 152 50 structural structural JJ cord-294218-v4gjabp3 152 51 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 152 52 . . . cord-294218-v4gjabp3 153 1 No no DT cord-294218-v4gjabp3 153 2 processing processing NN cord-294218-v4gjabp3 153 3 of of IN cord-294218-v4gjabp3 153 4 the the DT cord-294218-v4gjabp3 153 5 p52 p52 NN cord-294218-v4gjabp3 153 6 nucleocapsid nucleocapsid NN cord-294218-v4gjabp3 153 7 ( ( -LRB- cord-294218-v4gjabp3 153 8 N N NNP cord-294218-v4gjabp3 153 9 ) ) -RRB- cord-294218-v4gjabp3 153 10 protein protein NN cord-294218-v4gjabp3 153 11 was be VBD cord-294218-v4gjabp3 153 12 apparent apparent JJ cord-294218-v4gjabp3 153 13 . . . cord-294218-v4gjabp3 154 1 Two two CD cord-294218-v4gjabp3 154 2 additional additional JJ cord-294218-v4gjabp3 154 3 virus virus NN cord-294218-v4gjabp3 154 4 - - HYPH cord-294218-v4gjabp3 154 5 specific specific JJ cord-294218-v4gjabp3 154 6 binding bind VBG cord-294218-v4gjabp3 154 7 proteins protein NNS cord-294218-v4gjabp3 154 8 ( ( -LRB- cord-294218-v4gjabp3 154 9 48,000 48,000 CD cord-294218-v4gjabp3 154 10 and and CC cord-294218-v4gjabp3 154 11 46,000 46,000 CD cord-294218-v4gjabp3 154 12 ) ) -RRB- cord-294218-v4gjabp3 154 13 which which WDT cord-294218-v4gjabp3 154 14 migrated migrate VBD cord-294218-v4gjabp3 154 15 slightly slightly RB cord-294218-v4gjabp3 154 16 ahead ahead RB cord-294218-v4gjabp3 154 17 of of IN cord-294218-v4gjabp3 154 18 N n CD cord-294218-v4gjabp3 154 19 were be VBD cord-294218-v4gjabp3 154 20 also also RB cord-294218-v4gjabp3 154 21 identified identify VBN cord-294218-v4gjabp3 154 22 for for IN cord-294218-v4gjabp3 154 23 MHV MHV NNP cord-294218-v4gjabp3 154 24 and and CC cord-294218-v4gjabp3 154 25 IBV IBV NNP cord-294218-v4gjabp3 154 26 [ [ -LRB- cord-294218-v4gjabp3 154 27 27 27 CD cord-294218-v4gjabp3 154 28 , , , cord-294218-v4gjabp3 154 29 32 32 CD cord-294218-v4gjabp3 154 30 , , , cord-294218-v4gjabp3 154 31 37 37 CD cord-294218-v4gjabp3 154 32 ] ] -RRB- cord-294218-v4gjabp3 154 33 . . . cord-294218-v4gjabp3 155 1 These these DT cord-294218-v4gjabp3 155 2 two two CD cord-294218-v4gjabp3 155 3 species specie NNS cord-294218-v4gjabp3 155 4 reacted react VBD cord-294218-v4gjabp3 155 5 with with IN cord-294218-v4gjabp3 155 6 monospecific monospecific JJ cord-294218-v4gjabp3 155 7 anti anti JJ cord-294218-v4gjabp3 155 8 - - JJ cord-294218-v4gjabp3 155 9 N n JJ cord-294218-v4gjabp3 155 10 antibody antibody NN cord-294218-v4gjabp3 155 11 and and CC cord-294218-v4gjabp3 155 12 , , , cord-294218-v4gjabp3 155 13 in in IN cord-294218-v4gjabp3 155 14 vitro vitro FW cord-294218-v4gjabp3 155 15 translation translation NN cord-294218-v4gjabp3 155 16 studies study NNS cord-294218-v4gjabp3 155 17 of of IN cord-294218-v4gjabp3 155 18 the the DT cord-294218-v4gjabp3 155 19 N N NNP cord-294218-v4gjabp3 155 20 gene gene NN cord-294218-v4gjabp3 155 21 have have VBP cord-294218-v4gjabp3 155 22 Shown show VBN cord-294218-v4gjabp3 155 23 that that IN cord-294218-v4gjabp3 155 24 they -PRON- PRP cord-294218-v4gjabp3 155 25 may may MD cord-294218-v4gjabp3 155 26 correspond correspond VB cord-294218-v4gjabp3 155 27 to to IN cord-294218-v4gjabp3 155 28 degradation degradation NN cord-294218-v4gjabp3 155 29 products product NNS cord-294218-v4gjabp3 155 30 of of IN cord-294218-v4gjabp3 155 31 N n CD cord-294218-v4gjabp3 155 32 [ [ -LRB- cord-294218-v4gjabp3 155 33 26 26 CD cord-294218-v4gjabp3 155 34 , , , cord-294218-v4gjabp3 155 35 28 28 CD cord-294218-v4gjabp3 155 36 , , , cord-294218-v4gjabp3 155 37 33 33 CD cord-294218-v4gjabp3 155 38 ] ] -RRB- cord-294218-v4gjabp3 155 39 . . . cord-294218-v4gjabp3 156 1 The the DT cord-294218-v4gjabp3 156 2 30 30 CD cord-294218-v4gjabp3 156 3 - - SYM cord-294218-v4gjabp3 156 4 32 32 CD cord-294218-v4gjabp3 156 5 K K NNP cord-294218-v4gjabp3 156 6 polypeptide polypeptide NN cord-294218-v4gjabp3 156 7 species specie NNS cord-294218-v4gjabp3 156 8 present present JJ cord-294218-v4gjabp3 156 9 in in IN cord-294218-v4gjabp3 156 10 TCV TCV NNP cord-294218-v4gjabp3 156 11 - - HYPH cord-294218-v4gjabp3 156 12 infected infect VBN cord-294218-v4gjabp3 156 13 cell cell NN cord-294218-v4gjabp3 156 14 lysates lysate NNS cord-294218-v4gjabp3 156 15 is be VBZ cord-294218-v4gjabp3 156 16 apparently apparently RB cord-294218-v4gjabp3 156 17 a a DT cord-294218-v4gjabp3 156 18 virus virus NN cord-294218-v4gjabp3 156 19 - - HYPH cord-294218-v4gjabp3 156 20 induced induce VBN cord-294218-v4gjabp3 156 21 host host NN cord-294218-v4gjabp3 156 22 cell cell NN cord-294218-v4gjabp3 156 23 or or CC cord-294218-v4gjabp3 156 24 non non JJ cord-294218-v4gjabp3 156 25 - - JJ cord-294218-v4gjabp3 156 26 structural structural JJ cord-294218-v4gjabp3 156 27 protein protein NN cord-294218-v4gjabp3 156 28 , , , cord-294218-v4gjabp3 156 29 as as IN cord-294218-v4gjabp3 156 30 it -PRON- PRP cord-294218-v4gjabp3 156 31 was be VBD cord-294218-v4gjabp3 156 32 not not RB cord-294218-v4gjabp3 156 33 revealed reveal VBN cord-294218-v4gjabp3 156 34 by by IN cord-294218-v4gjabp3 156 35 Western Western NNP cord-294218-v4gjabp3 156 36 - - HYPH cord-294218-v4gjabp3 156 37 immunoblotting immunoblotting NN cord-294218-v4gjabp3 156 38 . . . cord-294218-v4gjabp3 157 1 A a DT cord-294218-v4gjabp3 157 2 non non JJ cord-294218-v4gjabp3 157 3 - - JJ cord-294218-v4gjabp3 157 4 structural structural JJ cord-294218-v4gjabp3 157 5 protein protein NN cord-294218-v4gjabp3 157 6 with with IN cord-294218-v4gjabp3 157 7 a a DT cord-294218-v4gjabp3 157 8 similar similar JJ cord-294218-v4gjabp3 157 9 mol.wt mol.wt NN cord-294218-v4gjabp3 157 10 . . . cord-294218-v4gjabp3 158 1 also also RB cord-294218-v4gjabp3 158 2 has have VBZ cord-294218-v4gjabp3 158 3 been be VBN cord-294218-v4gjabp3 158 4 detected detect VBN cord-294218-v4gjabp3 158 5 in in IN cord-294218-v4gjabp3 158 6 MHV MHV NNP cord-294218-v4gjabp3 158 7 - - HYPH cord-294218-v4gjabp3 158 8 A59 A59 NNP cord-294218-v4gjabp3 158 9 infected infect VBN cord-294218-v4gjabp3 158 10 cel cel NN cord-294218-v4gjabp3 158 11 lysates lysate NNS cord-294218-v4gjabp3 158 12 , , , cord-294218-v4gjabp3 158 13 and and CC cord-294218-v4gjabp3 158 14 a a DT cord-294218-v4gjabp3 158 15 protein protein NN cord-294218-v4gjabp3 158 16 with with IN cord-294218-v4gjabp3 158 17 a a DT cord-294218-v4gjabp3 158 18 mol.wt mol.wt NNP cord-294218-v4gjabp3 158 19 , , , cord-294218-v4gjabp3 158 20 of of IN cord-294218-v4gjabp3 158 21 28,000 28,000 CD cord-294218-v4gjabp3 158 22 was be VBD cord-294218-v4gjabp3 158 23 also also RB cord-294218-v4gjabp3 158 24 obtained obtain VBN cord-294218-v4gjabp3 158 25 following follow VBG cord-294218-v4gjabp3 158 26 cell cell NN cord-294218-v4gjabp3 158 27 - - HYPH cord-294218-v4gjabp3 158 28 free free JJ cord-294218-v4gjabp3 158 29 translation translation NN cord-294218-v4gjabp3 158 30 of of IN cord-294218-v4gjabp3 158 31 the the DT cord-294218-v4gjabp3 158 32 virion virion NN cord-294218-v4gjabp3 158 33 genomic genomic JJ cord-294218-v4gjabp3 158 34 RNA RNA NNP cord-294218-v4gjabp3 158 35 [ [ -LRB- cord-294218-v4gjabp3 158 36 8 8 CD cord-294218-v4gjabp3 158 37 , , , cord-294218-v4gjabp3 158 38 32 32 CD cord-294218-v4gjabp3 158 39 ] ] -RRB- cord-294218-v4gjabp3 158 40 . . . cord-294218-v4gjabp3 159 1 Since since IN cord-294218-v4gjabp3 159 2 p28 p28 NNP cord-294218-v4gjabp3 159 3 is be VBZ cord-294218-v4gjabp3 159 4 a a DT cord-294218-v4gjabp3 159 5 basic basic JJ cord-294218-v4gjabp3 159 6 protein protein NN cord-294218-v4gjabp3 159 7 which which WDT cord-294218-v4gjabp3 159 8 is be VBZ cord-294218-v4gjabp3 159 9 most most RBS cord-294218-v4gjabp3 159 10 abundant abundant JJ cord-294218-v4gjabp3 159 11 in in IN cord-294218-v4gjabp3 159 12 infected infected JJ cord-294218-v4gjabp3 159 13 cells cell NNS cord-294218-v4gjabp3 159 14 late late RB cord-294218-v4gjabp3 159 15 in in IN cord-294218-v4gjabp3 159 16 infection infection NN cord-294218-v4gjabp3 159 17 , , , cord-294218-v4gjabp3 159 18 it -PRON- PRP cord-294218-v4gjabp3 159 19 has have VBZ cord-294218-v4gjabp3 159 20 been be VBN cord-294218-v4gjabp3 159 21 suggested suggest VBN cord-294218-v4gjabp3 159 22 that that IN cord-294218-v4gjabp3 159 23 it -PRON- PRP cord-294218-v4gjabp3 159 24 may may MD cord-294218-v4gjabp3 159 25 be be VB cord-294218-v4gjabp3 159 26 involved involve VBN cord-294218-v4gjabp3 159 27 in in IN cord-294218-v4gjabp3 159 28 the the DT cord-294218-v4gjabp3 159 29 processing processing NN cord-294218-v4gjabp3 159 30 of of IN cord-294218-v4gjabp3 159 31 the the DT cord-294218-v4gjabp3 159 32 genomic genomic JJ cord-294218-v4gjabp3 159 33 or or CC cord-294218-v4gjabp3 159 34 subgenomic subgenomic JJ cord-294218-v4gjabp3 159 35 RNAs rna NNS cord-294218-v4gjabp3 159 36 . . . cord-294218-v4gjabp3 160 1 Pulse pulse NN cord-294218-v4gjabp3 160 2 - - HYPH cord-294218-v4gjabp3 160 3 chased chase VBN cord-294218-v4gjabp3 160 4 studies study NNS cord-294218-v4gjabp3 160 5 also also RB cord-294218-v4gjabp3 160 6 revealed reveal VBD cord-294218-v4gjabp3 160 7 that that IN cord-294218-v4gjabp3 160 8 TCV TCV NNP cord-294218-v4gjabp3 160 9 peplomeric peplomeric JJ cord-294218-v4gjabp3 160 10 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 160 11 undergo undergo VBP cord-294218-v4gjabp3 160 12 considerable considerable JJ cord-294218-v4gjabp3 160 13 post post JJ cord-294218-v4gjabp3 160 14 - - JJ cord-294218-v4gjabp3 160 15 translational translational JJ cord-294218-v4gjabp3 160 16 changes change NNS cord-294218-v4gjabp3 160 17 before before IN cord-294218-v4gjabp3 160 18 incorporation incorporation NN cord-294218-v4gjabp3 160 19 into into IN cord-294218-v4gjabp3 160 20 the the DT cord-294218-v4gjabp3 160 21 virion virion NN cord-294218-v4gjabp3 160 22 . . . cord-294218-v4gjabp3 161 1 First first JJ cord-294218-v4gjabp3 161 2 glycosylation glycosylation NN cord-294218-v4gjabp3 161 3 of of IN cord-294218-v4gjabp3 161 4 the the DT cord-294218-v4gjabp3 161 5 primary primary JJ cord-294218-v4gjabp3 161 6 translation translation NN cord-294218-v4gjabp3 161 7 product product NN cord-294218-v4gjabp3 161 8 from from IN cord-294218-v4gjabp3 161 9 the the DT cord-294218-v4gjabp3 161 10 E2 E2 NNP cord-294218-v4gjabp3 161 11 gene gene NN cord-294218-v4gjabp3 161 12 may may MD cord-294218-v4gjabp3 161 13 result result VB cord-294218-v4gjabp3 161 14 in in IN cord-294218-v4gjabp3 161 15 the the DT cord-294218-v4gjabp3 161 16 synthesis synthesis NN cord-294218-v4gjabp3 161 17 of of IN cord-294218-v4gjabp3 161 18 the the DT cord-294218-v4gjabp3 161 19 gp150 gp150 CD cord-294218-v4gjabp3 161 20 - - HYPH cord-294218-v4gjabp3 161 21 170,000 170,000 CD cord-294218-v4gjabp3 161 22 species specie NNS cord-294218-v4gjabp3 161 23 , , , cord-294218-v4gjabp3 161 24 and and CC cord-294218-v4gjabp3 161 25 further further JJ cord-294218-v4gjabp3 161 26 glycosylation glycosylation NN cord-294218-v4gjabp3 161 27 yields yield NNS cord-294218-v4gjabp3 161 28 gp gp NNP cord-294218-v4gjabp3 161 29 200 200 CD cord-294218-v4gjabp3 161 30 . . . cord-294218-v4gjabp3 162 1 Subsequent subsequent JJ cord-294218-v4gjabp3 162 2 proteolytic proteolytic JJ cord-294218-v4gjabp3 162 3 cleavage cleavage NN cord-294218-v4gjabp3 162 4 of of IN cord-294218-v4gjabp3 162 5 gp gp NN cord-294218-v4gjabp3 162 6 200 200 CD cord-294218-v4gjabp3 162 7 to to TO cord-294218-v4gjabp3 162 8 yield yield VB cord-294218-v4gjabp3 162 9 gp gp NNP cord-294218-v4gjabp3 162 10 120 120 CD cord-294218-v4gjabp3 162 11 and and CC cord-294218-v4gjabp3 162 12 gp gp NNP cord-294218-v4gjabp3 162 13 100 100 CD cord-294218-v4gjabp3 162 14 , , , cord-294218-v4gjabp3 162 15 as as IN cord-294218-v4gjabp3 162 16 demonstrated demonstrate VBN cord-294218-v4gjabp3 162 17 in in IN cord-294218-v4gjabp3 162 18 the the DT cord-294218-v4gjabp3 162 19 accompanying accompany VBG cord-294218-v4gjabp3 162 20 paper paper NN cord-294218-v4gjabp3 162 21 , , , cord-294218-v4gjabp3 162 22 appeared appear VBD cord-294218-v4gjabp3 162 23 to to TO cord-294218-v4gjabp3 162 24 occur occur VB cord-294218-v4gjabp3 162 25 quite quite RB cord-294218-v4gjabp3 162 26 efficiently efficiently RB cord-294218-v4gjabp3 162 27 , , , cord-294218-v4gjabp3 162 28 as as IN cord-294218-v4gjabp3 162 29 these these DT cord-294218-v4gjabp3 162 30 two two CD cord-294218-v4gjabp3 162 31 species specie NNS cord-294218-v4gjabp3 162 32 were be VBD cord-294218-v4gjabp3 162 33 the the DT cord-294218-v4gjabp3 162 34 predominant predominant JJ cord-294218-v4gjabp3 162 35 species specie NNS cord-294218-v4gjabp3 162 36 precipitated precipitate VBN cord-294218-v4gjabp3 162 37 from from IN cord-294218-v4gjabp3 162 38 TCV TCV NNP cord-294218-v4gjabp3 162 39 - - HYPH cord-294218-v4gjabp3 162 40 infected infect VBN cord-294218-v4gjabp3 162 41 cell cell NN cord-294218-v4gjabp3 162 42 extracts extract NNS cord-294218-v4gjabp3 162 43 . . . cord-294218-v4gjabp3 163 1 This this DT cord-294218-v4gjabp3 163 2 pattern pattern NN cord-294218-v4gjabp3 163 3 of of IN cord-294218-v4gjabp3 163 4 processing processing NN cord-294218-v4gjabp3 163 5 of of IN cord-294218-v4gjabp3 163 6 E2 E2 NNP cord-294218-v4gjabp3 163 7 is be VBZ cord-294218-v4gjabp3 163 8 similar similar JJ cord-294218-v4gjabp3 163 9 to to IN cord-294218-v4gjabp3 163 10 the the DT cord-294218-v4gjabp3 163 11 patterns pattern NNS cord-294218-v4gjabp3 163 12 proposed propose VBN cord-294218-v4gjabp3 163 13 for for IN cord-294218-v4gjabp3 163 14 the the DT cord-294218-v4gjabp3 163 15 E2 E2 NNP cord-294218-v4gjabp3 163 16 of of IN cord-294218-v4gjabp3 163 17 BCV BCV NNP cord-294218-v4gjabp3 163 18 , , , cord-294218-v4gjabp3 163 19 MHV MHV NNP cord-294218-v4gjabp3 163 20 , , , cord-294218-v4gjabp3 163 21 and and CC cord-294218-v4gjabp3 163 22 IBV IBV NNP cord-294218-v4gjabp3 163 23 [ [ -LRB- cord-294218-v4gjabp3 163 24 9 9 CD cord-294218-v4gjabp3 163 25 , , , cord-294218-v4gjabp3 163 26 36 36 CD cord-294218-v4gjabp3 163 27 , , , cord-294218-v4gjabp3 163 28 403 403 CD cord-294218-v4gjabp3 163 29 . . . cord-294218-v4gjabp3 164 1 A a DT cord-294218-v4gjabp3 164 2 primary primary JJ cord-294218-v4gjabp3 164 3 glycosylated glycosylated JJ cord-294218-v4gjabp3 164 4 precursor precursor NN cord-294218-v4gjabp3 164 5 with with IN cord-294218-v4gjabp3 164 6 apparent apparent JJ cord-294218-v4gjabp3 164 7 mol.wt mol.wt NNP cord-294218-v4gjabp3 164 8 , , , cord-294218-v4gjabp3 164 9 of of IN cord-294218-v4gjabp3 164 10 170,000 170,000 CD cord-294218-v4gjabp3 164 11 also also RB cord-294218-v4gjabp3 164 12 has have VBZ cord-294218-v4gjabp3 164 13 been be VBN cord-294218-v4gjabp3 164 14 identified identify VBN cord-294218-v4gjabp3 164 15 for for IN cord-294218-v4gjabp3 164 16 BCV BCV NNP cord-294218-v4gjabp3 164 17 using use VBG cord-294218-v4gjabp3 164 18 anti anti JJ cord-294218-v4gjabp3 164 19 - - JJ cord-294218-v4gjabp3 164 20 E2 e2 JJ cord-294218-v4gjabp3 164 21 monoclonal monoclonal JJ cord-294218-v4gjabp3 164 22 antibodies antibody NNS cord-294218-v4gjabp3 164 23 [ [ -LRB- cord-294218-v4gjabp3 164 24 9 9 CD cord-294218-v4gjabp3 164 25 , , , cord-294218-v4gjabp3 164 26 103 103 CD cord-294218-v4gjabp3 164 27 . . . cord-294218-v4gjabp3 165 1 In in IN cord-294218-v4gjabp3 165 2 case case NN cord-294218-v4gjabp3 165 3 of of IN cord-294218-v4gjabp3 165 4 TCV TCV NNP cord-294218-v4gjabp3 165 5 , , , cord-294218-v4gjabp3 165 6 proteolytic proteolytic JJ cord-294218-v4gjabp3 165 7 cleavage cleavage NN cord-294218-v4gjabp3 165 8 of of IN cord-294218-v4gjabp3 165 9 E2 E2 NNP cord-294218-v4gjabp3 165 10 probably probably RB cord-294218-v4gjabp3 165 11 occurs occur VBZ cord-294218-v4gjabp3 165 12 also also RB cord-294218-v4gjabp3 165 13 prior prior RB cord-294218-v4gjabp3 165 14 to to IN cord-294218-v4gjabp3 165 15 the the DT cord-294218-v4gjabp3 165 16 final final JJ cord-294218-v4gjabp3 165 17 glycosylation glycosylation NN cord-294218-v4gjabp3 165 18 step step NN cord-294218-v4gjabp3 165 19 . . . cord-294218-v4gjabp3 166 1 A a DT cord-294218-v4gjabp3 166 2 90,000 90,000 CD cord-294218-v4gjabp3 166 3 mol.wt mol.wt NNP cord-294218-v4gjabp3 166 4 , , , cord-294218-v4gjabp3 166 5 non non JJ cord-294218-v4gjabp3 166 6 - - JJ cord-294218-v4gjabp3 166 7 glycosylated glycosylated JJ cord-294218-v4gjabp3 166 8 polypeptide polypeptide NN cord-294218-v4gjabp3 166 9 was be VBD cord-294218-v4gjabp3 166 10 revealed reveal VBN cord-294218-v4gjabp3 166 11 by by IN cord-294218-v4gjabp3 166 12 immunoprecipitation immunoprecipitation NN cord-294218-v4gjabp3 166 13 prior prior RB cord-294218-v4gjabp3 166 14 to to IN cord-294218-v4gjabp3 166 15 the the DT cord-294218-v4gjabp3 166 16 appearance appearance NN cord-294218-v4gjabp3 166 17 of of IN cord-294218-v4gjabp3 166 18 gp gp NNP cord-294218-v4gjabp3 166 19 170 170 CD cord-294218-v4gjabp3 166 20 and and CC cord-294218-v4gjabp3 166 21 , , , cord-294218-v4gjabp3 166 22 was be VBD cord-294218-v4gjabp3 166 23 apparently apparently RB cord-294218-v4gjabp3 166 24 chased chase VBN cord-294218-v4gjabp3 166 25 to to TO cord-294218-v4gjabp3 166 26 give give VB cord-294218-v4gjabp3 166 27 the the DT cord-294218-v4gjabp3 166 28 TCV TCV NNP cord-294218-v4gjabp3 166 29 virion virion NN cord-294218-v4gjabp3 166 30 gp gp NN cord-294218-v4gjabp3 166 31 100 100 CD cord-294218-v4gjabp3 166 32 . . . cord-294218-v4gjabp3 167 1 Whether whether IN cord-294218-v4gjabp3 167 2 these these DT cord-294218-v4gjabp3 167 3 two two CD cord-294218-v4gjabp3 167 4 intracetlular intracetlular JJ cord-294218-v4gjabp3 167 5 polypeptides polypeptide NNS cord-294218-v4gjabp3 167 6 are be VBP cord-294218-v4gjabp3 167 7 in in IN cord-294218-v4gjabp3 167 8 fact fact NN cord-294218-v4gjabp3 167 9 related relate VBN cord-294218-v4gjabp3 167 10 remains remain NNS cord-294218-v4gjabp3 167 11 to to TO cord-294218-v4gjabp3 167 12 be be VB cord-294218-v4gjabp3 167 13 demonstrated demonstrate VBN cord-294218-v4gjabp3 167 14 . . . cord-294218-v4gjabp3 168 1 It -PRON- PRP cord-294218-v4gjabp3 168 2 may may MD cord-294218-v4gjabp3 168 3 be be VB cord-294218-v4gjabp3 168 4 possible possible JJ cord-294218-v4gjabp3 168 5 that that IN cord-294218-v4gjabp3 168 6 a a DT cord-294218-v4gjabp3 168 7 certain certain JJ cord-294218-v4gjabp3 168 8 amount amount NN cord-294218-v4gjabp3 168 9 of of IN cord-294218-v4gjabp3 168 10 a a DT cord-294218-v4gjabp3 168 11 primary primary JJ cord-294218-v4gjabp3 168 12 E2 E2 NNP cord-294218-v4gjabp3 168 13 apoprotein apoprotein NN cord-294218-v4gjabp3 168 14 is be VBZ cord-294218-v4gjabp3 168 15 cleaved cleave VBN cord-294218-v4gjabp3 168 16 and and CC cord-294218-v4gjabp3 168 17 then then RB cord-294218-v4gjabp3 168 18 further further RB cord-294218-v4gjabp3 168 19 glycosylated glycosylate VBN cord-294218-v4gjabp3 168 20 to to TO cord-294218-v4gjabp3 168 21 give give VB cord-294218-v4gjabp3 168 22 the the DT cord-294218-v4gjabp3 168 23 final final JJ cord-294218-v4gjabp3 168 24 gp gp NNP cord-294218-v4gjabp3 168 25 100 100 CD cord-294218-v4gjabp3 168 26 - - HYPH cord-294218-v4gjabp3 168 27 120 120 CD cord-294218-v4gjabp3 168 28 . . . cord-294218-v4gjabp3 169 1 A a DT cord-294218-v4gjabp3 169 2 recent recent JJ cord-294218-v4gjabp3 169 3 study study NN cord-294218-v4gjabp3 169 4 on on IN cord-294218-v4gjabp3 169 5 the the DT cord-294218-v4gjabp3 169 6 intracellular intracellular JJ cord-294218-v4gjabp3 169 7 processing processing NN cord-294218-v4gjabp3 169 8 of of IN cord-294218-v4gjabp3 169 9 measles measle NNS cord-294218-v4gjabp3 169 10 virus virus NN cord-294218-v4gjabp3 169 11 F F NNP cord-294218-v4gjabp3 169 12 and and CC cord-294218-v4gjabp3 169 13 HA HA NNP cord-294218-v4gjabp3 169 14 proteins protein NNS cord-294218-v4gjabp3 169 15 demonstrated demonstrate VBD cord-294218-v4gjabp3 169 16 that that IN cord-294218-v4gjabp3 169 17 glycosylation glycosylation NN cord-294218-v4gjabp3 169 18 was be VBD cord-294218-v4gjabp3 169 19 essential essential JJ cord-294218-v4gjabp3 169 20 to to IN cord-294218-v4gjabp3 169 21 the the DT cord-294218-v4gjabp3 169 22 post post JJ cord-294218-v4gjabp3 169 23 - - JJ cord-294218-v4gjabp3 169 24 translation translation JJ cord-294218-v4gjabp3 169 25 proteolytic proteolytic JJ cord-294218-v4gjabp3 169 26 cleavage cleavage NN cord-294218-v4gjabp3 169 27 to to TO cord-294218-v4gjabp3 169 28 proceed proceed VB cord-294218-v4gjabp3 169 29 [ [ -LRB- cord-294218-v4gjabp3 169 30 30 30 CD cord-294218-v4gjabp3 169 31 ] ] -RRB- cord-294218-v4gjabp3 169 32 . . . cord-294218-v4gjabp3 170 1 Similarly similarly RB cord-294218-v4gjabp3 170 2 , , , cord-294218-v4gjabp3 170 3 results result NNS cord-294218-v4gjabp3 170 4 obtained obtain VBN cord-294218-v4gjabp3 170 5 with with IN cord-294218-v4gjabp3 170 6 coronavirus coronavirus NN cord-294218-v4gjabp3 170 7 MHV MHV NNP cord-294218-v4gjabp3 170 8 - - HYPH cord-294218-v4gjabp3 170 9 A59 A59 NNP cord-294218-v4gjabp3 170 10 have have VBP cord-294218-v4gjabp3 170 11 suggested suggest VBN cord-294218-v4gjabp3 170 12 that that IN cord-294218-v4gjabp3 170 13 the the DT cord-294218-v4gjabp3 170 14 proteolytic proteolytic JJ cord-294218-v4gjabp3 170 15 cleavage cleavage NN cord-294218-v4gjabp3 170 16 of of IN cord-294218-v4gjabp3 170 17 E2 E2 NNP cord-294218-v4gjabp3 170 18 was be VBD cord-294218-v4gjabp3 170 19 a a DT cord-294218-v4gjabp3 170 20 post post JJ cord-294218-v4gjabp3 170 21 - - JJ cord-294218-v4gjabp3 170 22 translational translational JJ cord-294218-v4gjabp3 170 23 event event NN cord-294218-v4gjabp3 170 24 that that WDT cord-294218-v4gjabp3 170 25 occured occur VBD cord-294218-v4gjabp3 170 26 only only RB cord-294218-v4gjabp3 170 27 after after IN cord-294218-v4gjabp3 170 28 assembling assemble VBG cord-294218-v4gjabp3 170 29 of of IN cord-294218-v4gjabp3 170 30 the the DT cord-294218-v4gjabp3 170 31 virion virion NN cord-294218-v4gjabp3 170 32 and and CC cord-294218-v4gjabp3 170 33 further further JJ cord-294218-v4gjabp3 170 34 processing processing NN cord-294218-v4gjabp3 170 35 of of IN cord-294218-v4gjabp3 170 36 the the DT cord-294218-v4gjabp3 170 37 E2 E2 NNP cord-294218-v4gjabp3 170 38 protein protein NN cord-294218-v4gjabp3 170 39 in in IN cord-294218-v4gjabp3 170 40 the the DT cord-294218-v4gjabp3 170 41 Golgi Golgi NNP cord-294218-v4gjabp3 170 42 apparatus apparatus NN cord-294218-v4gjabp3 170 43 [ [ -LRB- cord-294218-v4gjabp3 170 44 -12 -12 NNS cord-294218-v4gjabp3 170 45 , , , cord-294218-v4gjabp3 170 46 20 20 CD cord-294218-v4gjabp3 170 47 , , , cord-294218-v4gjabp3 170 48 273 273 CD cord-294218-v4gjabp3 170 49 . . . cord-294218-v4gjabp3 171 1 With with IN cord-294218-v4gjabp3 171 2 TCV TCV NNP cord-294218-v4gjabp3 171 3 , , , cord-294218-v4gjabp3 171 4 gp gp NNP cord-294218-v4gjabp3 171 5 100 100 CD cord-294218-v4gjabp3 171 6 and and CC cord-294218-v4gjabp3 171 7 gp gp NN cord-294218-v4gjabp3 171 8 120 120 CD cord-294218-v4gjabp3 171 9 species specie NNS cord-294218-v4gjabp3 171 10 were be VBD cord-294218-v4gjabp3 171 11 also also RB cord-294218-v4gjabp3 171 12 demonstrated demonstrate VBN cord-294218-v4gjabp3 171 13 after after IN cord-294218-v4gjabp3 171 14 treatment treatment NN cord-294218-v4gjabp3 171 15 with with IN cord-294218-v4gjabp3 171 16 monensin monensin NNP cord-294218-v4gjabp3 171 17 , , , cord-294218-v4gjabp3 171 18 an an DT cord-294218-v4gjabp3 171 19 inhibitor inhibitor NN cord-294218-v4gjabp3 171 20 of of IN cord-294218-v4gjabp3 171 21 the the DT cord-294218-v4gjabp3 171 22 Golgi Golgi NNP cord-294218-v4gjabp3 171 23 function function NN cord-294218-v4gjabp3 171 24 , , , cord-294218-v4gjabp3 171 25 suggesting suggest VBG cord-294218-v4gjabp3 171 26 that that IN cord-294218-v4gjabp3 171 27 the the DT cord-294218-v4gjabp3 171 28 first first JJ cord-294218-v4gjabp3 171 29 glycosylation glycosylation NN cord-294218-v4gjabp3 171 30 acquired acquire VBN cord-294218-v4gjabp3 171 31 in in IN cord-294218-v4gjabp3 171 32 the the DT cord-294218-v4gjabp3 171 33 RER rer NN cord-294218-v4gjabp3 171 34 may may MD cord-294218-v4gjabp3 171 35 be be VB cord-294218-v4gjabp3 171 36 sufficient sufficient JJ cord-294218-v4gjabp3 171 37 . . . cord-294218-v4gjabp3 172 1 The the DT cord-294218-v4gjabp3 172 2 90 90 CD cord-294218-v4gjabp3 172 3 K K NNP cord-294218-v4gjabp3 172 4 protein protein NN cord-294218-v4gjabp3 172 5 may may MD cord-294218-v4gjabp3 172 6 also also RB cord-294218-v4gjabp3 172 7 represent represent VB cord-294218-v4gjabp3 172 8 a a DT cord-294218-v4gjabp3 172 9 host host NN cord-294218-v4gjabp3 172 10 cell cell NN cord-294218-v4gjabp3 172 11 component component NN cord-294218-v4gjabp3 172 12 similar similar JJ cord-294218-v4gjabp3 172 13 in in IN cord-294218-v4gjabp3 172 14 mol.wt mol.wt NNP cord-294218-v4gjabp3 172 15 . . . cord-294218-v4gjabp3 173 1 to to IN cord-294218-v4gjabp3 173 2 a a DT cord-294218-v4gjabp3 173 3 group group NN cord-294218-v4gjabp3 173 4 of of IN cord-294218-v4gjabp3 173 5 resident resident JJ cord-294218-v4gjabp3 173 6 proteins protein NNS cord-294218-v4gjabp3 173 7 of of IN cord-294218-v4gjabp3 173 8 the the DT cord-294218-v4gjabp3 173 9 ER ER NNP cord-294218-v4gjabp3 173 10 identified identify VBN cord-294218-v4gjabp3 173 11 as as IN cord-294218-v4gjabp3 173 12 putative putative JJ cord-294218-v4gjabp3 173 13 receptors receptor NNS cord-294218-v4gjabp3 173 14 or or CC cord-294218-v4gjabp3 173 15 carriers carrier NNS cord-294218-v4gjabp3 173 16 involved involve VBN cord-294218-v4gjabp3 173 17 in in IN cord-294218-v4gjabp3 173 18 the the DT cord-294218-v4gjabp3 173 19 RER RER NNP cord-294218-v4gjabp3 173 20 - - HYPH cord-294218-v4gjabp3 173 21 Golgi Golgi NNP cord-294218-v4gjabp3 173 22 translocation translocation NN cord-294218-v4gjabp3 173 23 step step NN cord-294218-v4gjabp3 173 24 [ [ -LRB- cord-294218-v4gjabp3 173 25 133 133 CD cord-294218-v4gjabp3 173 26 . . . cord-294218-v4gjabp3 174 1 The the DT cord-294218-v4gjabp3 174 2 " " `` cord-294218-v4gjabp3 174 3 glucose glucose NN cord-294218-v4gjabp3 174 4 - - HYPH cord-294218-v4gjabp3 174 5 regulated regulate VBN cord-294218-v4gjabp3 174 6 proteins protein NNS cord-294218-v4gjabp3 174 7 " " '' cord-294218-v4gjabp3 174 8 grp78 grp78 . cord-294218-v4gjabp3 175 1 and and CC cord-294218-v4gjabp3 175 2 grp94 grp94 UH cord-294218-v4gjabp3 175 3 , , , cord-294218-v4gjabp3 175 4 for for IN cord-294218-v4gjabp3 175 5 example example NN cord-294218-v4gjabp3 175 6 , , , cord-294218-v4gjabp3 175 7 have have VBP cord-294218-v4gjabp3 175 8 been be VBN cord-294218-v4gjabp3 175 9 identified identify VBN cord-294218-v4gjabp3 175 10 in in IN cord-294218-v4gjabp3 175 11 the the DT cord-294218-v4gjabp3 175 12 lumen lumen NN cord-294218-v4gjabp3 175 13 of of IN cord-294218-v4gjabp3 175 14 the the DT cord-294218-v4gjabp3 175 15 ER ER NNP cord-294218-v4gjabp3 175 16 of of IN cord-294218-v4gjabp3 175 17 a a DT cord-294218-v4gjabp3 175 18 large large JJ cord-294218-v4gjabp3 175 19 number number NN cord-294218-v4gjabp3 175 20 of of IN cord-294218-v4gjabp3 175 21 different different JJ cord-294218-v4gjabp3 175 22 types type NNS cord-294218-v4gjabp3 175 23 of of IN cord-294218-v4gjabp3 175 24 mammalian mammalian JJ cord-294218-v4gjabp3 175 25 cells cell NNS cord-294218-v4gjabp3 175 26 [ [ -LRB- cord-294218-v4gjabp3 175 27 243 243 CD cord-294218-v4gjabp3 175 28 . . . cord-294218-v4gjabp3 176 1 Recently recently RB cord-294218-v4gjabp3 176 2 , , , cord-294218-v4gjabp3 176 3 it -PRON- PRP cord-294218-v4gjabp3 176 4 has have VBZ cord-294218-v4gjabp3 176 5 been be VBN cord-294218-v4gjabp3 176 6 demonstrated demonstrate VBN cord-294218-v4gjabp3 176 7 that that IN cord-294218-v4gjabp3 176 8 unassembled unassembled JJ cord-294218-v4gjabp3 176 9 or or CC cord-294218-v4gjabp3 176 10 incorrectly incorrectly RB cord-294218-v4gjabp3 176 11 assembled assemble VBN cord-294218-v4gjabp3 176 12 HA HA NNP cord-294218-v4gjabp3 176 13 protein protein NN cord-294218-v4gjabp3 176 14 of of IN cord-294218-v4gjabp3 176 15 influenza influenza NN cord-294218-v4gjabp3 176 16 virus virus NN cord-294218-v4gjabp3 176 17 is be VBZ cord-294218-v4gjabp3 176 18 prevented prevent VBN cord-294218-v4gjabp3 176 19 from from IN cord-294218-v4gjabp3 176 20 leaving leave VBG cord-294218-v4gjabp3 176 21 ER ER NNP cord-294218-v4gjabp3 176 22 , , , cord-294218-v4gjabp3 176 23 being be VBG cord-294218-v4gjabp3 176 24 complexed complexe VBN cord-294218-v4gjabp3 176 25 to to IN cord-294218-v4gjabp3 176 26 a a DT cord-294218-v4gjabp3 176 27 cellular cellular JJ cord-294218-v4gjabp3 176 28 protein protein NN cord-294218-v4gjabp3 176 29 with with IN cord-294218-v4gjabp3 176 30 approximate approximate JJ cord-294218-v4gjabp3 176 31 mol.wt mol.wt NNP cord-294218-v4gjabp3 176 32 , , , cord-294218-v4gjabp3 176 33 of of IN cord-294218-v4gjabp3 176 34 90,000 90,000 CD cord-294218-v4gjabp3 176 35 resident resident NN cord-294218-v4gjabp3 176 36 in in IN cord-294218-v4gjabp3 176 37 the the DT cord-294218-v4gjabp3 176 38 lumen lumen NN cord-294218-v4gjabp3 176 39 of of IN cord-294218-v4gjabp3 176 40 ER ER NNP cord-294218-v4gjabp3 176 41 [ [ -LRB- cord-294218-v4gjabp3 176 42 14 14 CD cord-294218-v4gjabp3 176 43 ] ] -RRB- cord-294218-v4gjabp3 176 44 . . . cord-294218-v4gjabp3 177 1 A a DT cord-294218-v4gjabp3 177 2 host host NN cord-294218-v4gjabp3 177 3 - - HYPH cord-294218-v4gjabp3 177 4 cell cell NN cord-294218-v4gjabp3 177 5 protein protein NN cord-294218-v4gjabp3 177 6 with with IN cord-294218-v4gjabp3 177 7 similar similar JJ cord-294218-v4gjabp3 177 8 mol.wt mol.wt NNP cord-294218-v4gjabp3 177 9 , , , cord-294218-v4gjabp3 177 10 also also RB cord-294218-v4gjabp3 177 11 co co VBD cord-294218-v4gjabp3 177 12 - - VBN cord-294218-v4gjabp3 177 13 precipitated precipitate VBN cord-294218-v4gjabp3 177 14 from from IN cord-294218-v4gjabp3 177 15 lysates lysate NNS cord-294218-v4gjabp3 177 16 of of IN cord-294218-v4gjabp3 177 17 measles measles NNP cord-294218-v4gjabp3 177 18 virus virus NN cord-294218-v4gjabp3 177 19 - - HYPH cord-294218-v4gjabp3 177 20 infected infect VBN cord-294218-v4gjabp3 177 21 and and CC cord-294218-v4gjabp3 177 22 TM tm NN cord-294218-v4gjabp3 177 23 - - HYPH cord-294218-v4gjabp3 177 24 treated treat VBN cord-294218-v4gjabp3 177 25 cells cell NNS cord-294218-v4gjabp3 177 26 [ [ -LRB- cord-294218-v4gjabp3 177 27 30 30 CD cord-294218-v4gjabp3 177 28 ] ] -RRB- cord-294218-v4gjabp3 177 29 . . . cord-294218-v4gjabp3 178 1 Propolypeptides Propolypeptides NNP cord-294218-v4gjabp3 178 2 or or CC cord-294218-v4gjabp3 178 3 primary primary JJ cord-294218-v4gjabp3 178 4 - - HYPH cord-294218-v4gjabp3 178 5 translation translation NN cord-294218-v4gjabp3 178 6 products product NNS cord-294218-v4gjabp3 178 7 with with IN cord-294218-v4gjabp3 178 8 approximate approximate JJ cord-294218-v4gjabp3 178 9 mol.wts mol.wt NNS cord-294218-v4gjabp3 178 10 . . . cord-294218-v4gjabp3 179 1 of of IN cord-294218-v4gjabp3 179 2 127,000 127,000 CD cord-294218-v4gjabp3 179 3 to to TO cord-294218-v4gjabp3 179 4 146,000 146,000 CD cord-294218-v4gjabp3 179 5 have have VBP cord-294218-v4gjabp3 179 6 been be VBN cord-294218-v4gjabp3 179 7 predicted predict VBN cord-294218-v4gjabp3 179 8 from from IN cord-294218-v4gjabp3 179 9 the the DT cord-294218-v4gjabp3 179 10 amino amino NN cord-294218-v4gjabp3 179 11 acid acid NN cord-294218-v4gjabp3 179 12 sequences sequence NNS cord-294218-v4gjabp3 179 13 determined determine VBN cord-294218-v4gjabp3 179 14 by by IN cord-294218-v4gjabp3 179 15 sequencing sequence VBG cord-294218-v4gjabp3 179 16 analysis analysis NN cord-294218-v4gjabp3 179 17 of of IN cord-294218-v4gjabp3 179 18 the the DT cord-294218-v4gjabp3 179 19 genes gene NNS cord-294218-v4gjabp3 179 20 encoding encode VBG cord-294218-v4gjabp3 179 21 the the DT cord-294218-v4gjabp3 179 22 E2 E2 NNP cord-294218-v4gjabp3 179 23 of of IN cord-294218-v4gjabp3 179 24 IBV IBV NNP cord-294218-v4gjabp3 179 25 and and CC cord-294218-v4gjabp3 179 26 MHV MHV NNP cord-294218-v4gjabp3 179 27 [ [ -LRB- cord-294218-v4gjabp3 179 28 1 1 CD cord-294218-v4gjabp3 179 29 , , , cord-294218-v4gjabp3 179 30 20 20 CD cord-294218-v4gjabp3 179 31 , , , cord-294218-v4gjabp3 179 32 31 31 CD cord-294218-v4gjabp3 179 33 ] ] -RRB- cord-294218-v4gjabp3 179 34 . . . cord-294218-v4gjabp3 180 1 Non non JJ cord-294218-v4gjabp3 180 2 - - JJ cord-294218-v4gjabp3 180 3 glycosylated glycosylated JJ cord-294218-v4gjabp3 180 4 polypeptides polypeptide NNS cord-294218-v4gjabp3 180 5 with with IN cord-294218-v4gjabp3 180 6 apparent apparent JJ cord-294218-v4gjabp3 180 7 mol.wts mol.wt NNS cord-294218-v4gjabp3 180 8 , , , cord-294218-v4gjabp3 180 9 of of IN cord-294218-v4gjabp3 180 10 120 120 CD cord-294218-v4gjabp3 180 11 - - SYM cord-294218-v4gjabp3 180 12 130,000 130,000 CD cord-294218-v4gjabp3 180 13 and and CC cord-294218-v4gjabp3 180 14 150,000 150,000 CD cord-294218-v4gjabp3 180 15 were be VBD cord-294218-v4gjabp3 180 16 immunoprecipitated immunoprecipitate VBN cord-294218-v4gjabp3 180 17 from from IN cord-294218-v4gjabp3 180 18 extracts extract NNS cord-294218-v4gjabp3 180 19 of of IN cord-294218-v4gjabp3 180 20 TCV TCV NNP cord-294218-v4gjabp3 180 21 - - HYPH cord-294218-v4gjabp3 180 22 infected infect VBN cord-294218-v4gjabp3 180 23 , , , cord-294218-v4gjabp3 180 24 TM TM NNP cord-294218-v4gjabp3 180 25 - - HYPH cord-294218-v4gjabp3 180 26 treated treat VBN cord-294218-v4gjabp3 180 27 cells cell NNS cord-294218-v4gjabp3 180 28 . . . cord-294218-v4gjabp3 181 1 The the DT cord-294218-v4gjabp3 181 2 new new JJ cord-294218-v4gjabp3 181 3 intracellular intracellular JJ cord-294218-v4gjabp3 181 4 polypeptides polypeptide NNS cord-294218-v4gjabp3 181 5 were be VBD cord-294218-v4gjabp3 181 6 also also RB cord-294218-v4gjabp3 181 7 identified identify VBN cord-294218-v4gjabp3 181 8 by by IN cord-294218-v4gjabp3 181 9 Western Western NNP cord-294218-v4gjabp3 181 10 - - HYPH cord-294218-v4gjabp3 181 11 immunoblotting immunoblotting NN cord-294218-v4gjabp3 181 12 . . . cord-294218-v4gjabp3 182 1 Although although IN cord-294218-v4gjabp3 182 2 a a DT cord-294218-v4gjabp3 182 3 definitive definitive JJ cord-294218-v4gjabp3 182 4 precursor precursor NN cord-294218-v4gjabp3 182 5 - - HYPH cord-294218-v4gjabp3 182 6 final final JJ cord-294218-v4gjabp3 182 7 product product NN cord-294218-v4gjabp3 182 8 relationship relationship NN cord-294218-v4gjabp3 182 9 was be VBD cord-294218-v4gjabp3 182 10 not not RB cord-294218-v4gjabp3 182 11 demonstrated demonstrate VBN cord-294218-v4gjabp3 182 12 with with IN cord-294218-v4gjabp3 182 13 E2 E2 NNP cord-294218-v4gjabp3 182 14 or or CC cord-294218-v4gjabp3 182 15 E E NNP cord-294218-v4gjabp3 182 16 3 3 CD cord-294218-v4gjabp3 182 17 , , , cord-294218-v4gjabp3 182 18 the the DT cord-294218-v4gjabp3 182 19 latter latter JJ cord-294218-v4gjabp3 182 20 were be VBD cord-294218-v4gjabp3 182 21 not not RB cord-294218-v4gjabp3 182 22 synthesized synthesize VBN cord-294218-v4gjabp3 182 23 in in IN cord-294218-v4gjabp3 182 24 the the DT cord-294218-v4gjabp3 182 25 presence presence NN cord-294218-v4gjabp3 182 26 of of IN cord-294218-v4gjabp3 182 27 TM TM NNP cord-294218-v4gjabp3 182 28 . . . cord-294218-v4gjabp3 183 1 This this DT cord-294218-v4gjabp3 183 2 was be VBD cord-294218-v4gjabp3 183 3 confirmed confirm VBN cord-294218-v4gjabp3 183 4 by by IN cord-294218-v4gjabp3 183 5 radiolabeling radiolabele VBG cord-294218-v4gjabp3 183 6 with with IN cord-294218-v4gjabp3 183 7 glucosamine glucosamine NN cord-294218-v4gjabp3 183 8 and and CC cord-294218-v4gjabp3 183 9 by by IN cord-294218-v4gjabp3 183 10 EM EM NNP cord-294218-v4gjabp3 183 11 . . . cord-294218-v4gjabp3 184 1 Both both DT cord-294218-v4gjabp3 184 2 surface surface NN cord-294218-v4gjabp3 184 3 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 184 4 of of IN cord-294218-v4gjabp3 184 5 the the DT cord-294218-v4gjabp3 184 6 TCV TCV NNP cord-294218-v4gjabp3 184 7 virions virion NNS cord-294218-v4gjabp3 184 8 thus thus RB cord-294218-v4gjabp3 184 9 possess possess VBP cord-294218-v4gjabp3 184 10 N n CD cord-294218-v4gjabp3 184 11 - - HYPH cord-294218-v4gjabp3 184 12 linked link VBN cord-294218-v4gjabp3 184 13 oligosaccharides oligosaccharide NNS cord-294218-v4gjabp3 184 14 . . . cord-294218-v4gjabp3 185 1 The the DT cord-294218-v4gjabp3 185 2 observation observation NN cord-294218-v4gjabp3 185 3 that that IN cord-294218-v4gjabp3 185 4 the the DT cord-294218-v4gjabp3 185 5 nonglycosylated nonglycosylated JJ cord-294218-v4gjabp3 185 6 polypeptides polypeptide NNS cord-294218-v4gjabp3 185 7 were be VBD cord-294218-v4gjabp3 185 8 only only RB cord-294218-v4gjabp3 185 9 detected detect VBN cord-294218-v4gjabp3 185 10 in in IN cord-294218-v4gjabp3 185 11 the the DT cord-294218-v4gjabp3 185 12 presence presence NN cord-294218-v4gjabp3 185 13 of of IN cord-294218-v4gjabp3 185 14 this this DT cord-294218-v4gjabp3 185 15 glycosylation glycosylation NN cord-294218-v4gjabp3 185 16 inhibitor inhibitor NN cord-294218-v4gjabp3 185 17 indicated indicate VBD cord-294218-v4gjabp3 185 18 that that IN cord-294218-v4gjabp3 185 19 glycosylation glycosylation NN cord-294218-v4gjabp3 185 20 of of IN cord-294218-v4gjabp3 185 21 the the DT cord-294218-v4gjabp3 185 22 E2 E2 NNP cord-294218-v4gjabp3 185 23 and and CC cord-294218-v4gjabp3 185 24 E3 E3 NNP cord-294218-v4gjabp3 185 25 was be VBD cord-294218-v4gjabp3 185 26 initiated initiate VBN cord-294218-v4gjabp3 185 27 at at IN cord-294218-v4gjabp3 185 28 the the DT cord-294218-v4gjabp3 185 29 co co JJ cord-294218-v4gjabp3 185 30 - - JJ cord-294218-v4gjabp3 185 31 translational translational JJ cord-294218-v4gjabp3 185 32 level level NN cord-294218-v4gjabp3 185 33 . . . cord-294218-v4gjabp3 186 1 This this DT cord-294218-v4gjabp3 186 2 is be VBZ cord-294218-v4gjabp3 186 3 , , , cord-294218-v4gjabp3 186 4 again again RB cord-294218-v4gjabp3 186 5 , , , cord-294218-v4gjabp3 186 6 typical typical JJ cord-294218-v4gjabp3 186 7 for for IN cord-294218-v4gjabp3 186 8 N n CD cord-294218-v4gjabp3 186 9 - - HYPH cord-294218-v4gjabp3 186 10 glycosidic glycosidic JJ cord-294218-v4gjabp3 186 11 linkages linkage NNS cord-294218-v4gjabp3 186 12 . . . cord-294218-v4gjabp3 187 1 The the DT cord-294218-v4gjabp3 187 2 accumulation accumulation NN cord-294218-v4gjabp3 187 3 of of IN cord-294218-v4gjabp3 187 4 amorphous amorphous JJ cord-294218-v4gjabp3 187 5 material material NN cord-294218-v4gjabp3 187 6 in in IN cord-294218-v4gjabp3 187 7 the the DT cord-294218-v4gjabp3 187 8 cysternae cysternae NNP cord-294218-v4gjabp3 187 9 of of IN cord-294218-v4gjabp3 187 10 TCV TCV NNP cord-294218-v4gjabp3 187 11 - - HYPH cord-294218-v4gjabp3 187 12 infected infect VBN cord-294218-v4gjabp3 187 13 , , , cord-294218-v4gjabp3 187 14 TM TM NNP cord-294218-v4gjabp3 187 15 - - HYPH cord-294218-v4gjabp3 187 16 treated treat VBN cord-294218-v4gjabp3 187 17 cells cell NNS cord-294218-v4gjabp3 187 18 may may MD cord-294218-v4gjabp3 187 19 result result VB cord-294218-v4gjabp3 187 20 from from IN cord-294218-v4gjabp3 187 21 the the DT cord-294218-v4gjabp3 187 22 rapid rapid JJ cord-294218-v4gjabp3 187 23 degradation degradation NN cord-294218-v4gjabp3 187 24 of of IN cord-294218-v4gjabp3 187 25 these these DT cord-294218-v4gjabp3 187 26 putative putative JJ cord-294218-v4gjabp3 187 27 non non JJ cord-294218-v4gjabp3 187 28 - - JJ cord-294218-v4gjabp3 187 29 glycosylated glycosylated JJ cord-294218-v4gjabp3 187 30 precursors precursor NNS cord-294218-v4gjabp3 187 31 . . . cord-294218-v4gjabp3 188 1 Monensin Monensin NNP cord-294218-v4gjabp3 188 2 has have VBZ cord-294218-v4gjabp3 188 3 been be VBN cord-294218-v4gjabp3 188 4 shown show VBN cord-294218-v4gjabp3 188 5 to to TO cord-294218-v4gjabp3 188 6 produce produce VB cord-294218-v4gjabp3 188 7 an an DT cord-294218-v4gjabp3 188 8 intra intra JJ cord-294218-v4gjabp3 188 9 Golgi Golgi NNP cord-294218-v4gjabp3 188 10 blockade blockade NN cord-294218-v4gjabp3 188 11 of of IN cord-294218-v4gjabp3 188 12 a a DT cord-294218-v4gjabp3 188 13 number number NN cord-294218-v4gjabp3 188 14 of of IN cord-294218-v4gjabp3 188 15 secretory secretory JJ cord-294218-v4gjabp3 188 16 proteins protein NNS cord-294218-v4gjabp3 188 17 by by IN cord-294218-v4gjabp3 188 18 collapsing collapse VBG cord-294218-v4gjabp3 188 19 the the DT cord-294218-v4gjabp3 188 20 hydrogen hydrogen NN cord-294218-v4gjabp3 188 21 ion ion NN cord-294218-v4gjabp3 188 22 gradient gradient NN cord-294218-v4gjabp3 188 23 across across IN cord-294218-v4gjabp3 188 24 cellular cellular JJ cord-294218-v4gjabp3 188 25 membranes membrane NNS cord-294218-v4gjabp3 188 26 [ [ -LRB- cord-294218-v4gjabp3 188 27 1 1 CD cord-294218-v4gjabp3 188 28 ] ] -RRB- cord-294218-v4gjabp3 188 29 [ [ -LRB- cord-294218-v4gjabp3 188 30 2 2 CD cord-294218-v4gjabp3 188 31 ] ] -RRB- cord-294218-v4gjabp3 188 32 [ [ -LRB- cord-294218-v4gjabp3 188 33 3 3 CD cord-294218-v4gjabp3 188 34 ] ] -RRB- cord-294218-v4gjabp3 188 35 [ [ -LRB- cord-294218-v4gjabp3 188 36 4 4 CD cord-294218-v4gjabp3 188 37 ] ] -RRB- cord-294218-v4gjabp3 188 38 [ [ -LRB- cord-294218-v4gjabp3 188 39 5 5 CD cord-294218-v4gjabp3 188 40 ] ] -RRB- cord-294218-v4gjabp3 188 41 [ [ -LRB- cord-294218-v4gjabp3 188 42 6 6 CD cord-294218-v4gjabp3 188 43 ] ] -RRB- cord-294218-v4gjabp3 188 44 [ [ -LRB- cord-294218-v4gjabp3 188 45 7 7 CD cord-294218-v4gjabp3 188 46 ] ] -RRB- cord-294218-v4gjabp3 189 1 [ [ -LRB- cord-294218-v4gjabp3 189 2 8 8 CD cord-294218-v4gjabp3 189 3 ] ] -RRB- cord-294218-v4gjabp3 189 4 [ [ -LRB- cord-294218-v4gjabp3 189 5 9 9 CD cord-294218-v4gjabp3 189 6 ] ] -RRB- cord-294218-v4gjabp3 189 7 [ [ -LRB- cord-294218-v4gjabp3 189 8 10 10 CD cord-294218-v4gjabp3 189 9 ] ] -RRB- cord-294218-v4gjabp3 189 10 [ [ -LRB- cord-294218-v4gjabp3 189 11 11 11 CD cord-294218-v4gjabp3 189 12 ] ] -RRB- cord-294218-v4gjabp3 190 1 [ [ -LRB- cord-294218-v4gjabp3 190 2 12 12 CD cord-294218-v4gjabp3 190 3 ] ] -RRB- cord-294218-v4gjabp3 190 4 [ [ -LRB- cord-294218-v4gjabp3 190 5 13 13 CD cord-294218-v4gjabp3 190 6 ] ] -RRB- cord-294218-v4gjabp3 190 7 . . . cord-294218-v4gjabp3 191 1 It -PRON- PRP cord-294218-v4gjabp3 191 2 thus thus RB cord-294218-v4gjabp3 191 3 blocks block VBZ cord-294218-v4gjabp3 191 4 " " `` cord-294218-v4gjabp3 191 5 O o NN cord-294218-v4gjabp3 191 6 " " '' cord-294218-v4gjabp3 191 7 glycosylation glycosylation NN cord-294218-v4gjabp3 191 8 , , , cord-294218-v4gjabp3 191 9 but but CC cord-294218-v4gjabp3 191 10 not not RB cord-294218-v4gjabp3 191 11 N n CD cord-294218-v4gjabp3 191 12 - - HYPH cord-294218-v4gjabp3 191 13 glycosylation glycosylation NN cord-294218-v4gjabp3 191 14 which which WDT cord-294218-v4gjabp3 191 15 occurs occur VBZ cord-294218-v4gjabp3 191 16 in in IN cord-294218-v4gjabp3 191 17 the the DT cord-294218-v4gjabp3 191 18 RER rer NN cord-294218-v4gjabp3 191 19 . . . cord-294218-v4gjabp3 192 1 The the DT cord-294218-v4gjabp3 192 2 100 100 CD cord-294218-v4gjabp3 192 3 K K NNP cord-294218-v4gjabp3 192 4 and and CC cord-294218-v4gjabp3 192 5 t40 t40 NNP cord-294218-v4gjabp3 192 6 K K NNP cord-294218-v4gjabp3 192 7 species specie NNS cord-294218-v4gjabp3 192 8 were be VBD cord-294218-v4gjabp3 192 9 heavily heavily RB cord-294218-v4gjabp3 192 10 labeled label VBN cord-294218-v4gjabp3 192 11 with with IN cord-294218-v4gjabp3 192 12 glucosamine glucosamine NN cord-294218-v4gjabp3 192 13 in in IN cord-294218-v4gjabp3 192 14 the the DT cord-294218-v4gjabp3 192 15 presence presence NN cord-294218-v4gjabp3 192 16 of of IN cord-294218-v4gjabp3 192 17 monensin monensin NNP cord-294218-v4gjabp3 192 18 , , , cord-294218-v4gjabp3 192 19 which which WDT cord-294218-v4gjabp3 192 20 further further RB cord-294218-v4gjabp3 192 21 supported support VBD cord-294218-v4gjabp3 192 22 the the DT cord-294218-v4gjabp3 192 23 results result NNS cord-294218-v4gjabp3 192 24 obtained obtain VBN cord-294218-v4gjabp3 192 25 with with IN cord-294218-v4gjabp3 192 26 TM TM NNP cord-294218-v4gjabp3 192 27 . . . cord-294218-v4gjabp3 193 1 The the DT cord-294218-v4gjabp3 193 2 unglycosylated unglycosylated JJ cord-294218-v4gjabp3 193 3 60,000 60,000 CD cord-294218-v4gjabp3 193 4 and and CC cord-294218-v4gjabp3 193 5 130,000 130,000 CD cord-294218-v4gjabp3 193 6 mol.wt mol.wt NNP cord-294218-v4gjabp3 193 7 , , , cord-294218-v4gjabp3 193 8 proteins protein NNS cord-294218-v4gjabp3 193 9 species specie NNS cord-294218-v4gjabp3 193 10 immunoprecipitated immunoprecipitate VBN cord-294218-v4gjabp3 193 11 from from IN cord-294218-v4gjabp3 193 12 extracts extract NNS cord-294218-v4gjabp3 193 13 of of IN cord-294218-v4gjabp3 193 14 TCV TCV NNP cord-294218-v4gjabp3 193 15 - - HYPH cord-294218-v4gjabp3 193 16 infected infect VBN cord-294218-v4gjabp3 193 17 cells cell NNS cord-294218-v4gjabp3 193 18 , , , cord-294218-v4gjabp3 193 19 and and CC cord-294218-v4gjabp3 193 20 the the DT cord-294218-v4gjabp3 193 21 virion virion NN cord-294218-v4gjabp3 193 22 62 62 CD cord-294218-v4gjabp3 193 23 - - SYM cord-294218-v4gjabp3 193 24 65,000 65,000 CD cord-294218-v4gjabp3 193 25 and and CC cord-294218-v4gjabp3 193 26 140,000 140,000 CD cord-294218-v4gjabp3 193 27 mol.wt mol.wt NN cord-294218-v4gjabp3 193 28 , , , cord-294218-v4gjabp3 193 29 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 193 30 appear appear VBP cord-294218-v4gjabp3 193 31 to to TO cord-294218-v4gjabp3 193 32 be be VB cord-294218-v4gjabp3 193 33 different different JJ cord-294218-v4gjabp3 193 34 forms form NNS cord-294218-v4gjabp3 193 35 of of IN cord-294218-v4gjabp3 193 36 the the DT cord-294218-v4gjabp3 193 37 same same JJ cord-294218-v4gjabp3 193 38 viral viral JJ cord-294218-v4gjabp3 193 39 protein protein NN cord-294218-v4gjabp3 193 40 . . . cord-294218-v4gjabp3 194 1 The the DT cord-294218-v4gjabp3 194 2 non non JJ cord-294218-v4gjabp3 194 3 - - JJ cord-294218-v4gjabp3 194 4 glycosylated glycosylated JJ cord-294218-v4gjabp3 194 5 p60 p60 NN cord-294218-v4gjabp3 194 6 may may MD cord-294218-v4gjabp3 194 7 correspond correspond VB cord-294218-v4gjabp3 194 8 to to IN cord-294218-v4gjabp3 194 9 the the DT cord-294218-v4gjabp3 194 10 precursor precursor NN cord-294218-v4gjabp3 194 11 protein protein NN cord-294218-v4gjabp3 194 12 , , , cord-294218-v4gjabp3 194 13 which which WDT cord-294218-v4gjabp3 194 14 undergoes undergo VBZ cord-294218-v4gjabp3 194 15 glycosylation glycosylation NN cord-294218-v4gjabp3 194 16 to to TO cord-294218-v4gjabp3 194 17 yield yield VB cord-294218-v4gjabp3 194 18 the the DT cord-294218-v4gjabp3 194 19 gp62 gp62 NNP cord-294218-v4gjabp3 194 20 - - HYPH cord-294218-v4gjabp3 194 21 65 65 CD cord-294218-v4gjabp3 194 22 species specie NNS cord-294218-v4gjabp3 194 23 , , , cord-294218-v4gjabp3 194 24 before before IN cord-294218-v4gjabp3 194 25 rapid rapid JJ cord-294218-v4gjabp3 194 26 dimerization dimerization NN cord-294218-v4gjabp3 194 27 by by IN cord-294218-v4gjabp3 194 28 disulfide disulfide JJ cord-294218-v4gjabp3 194 29 bonds bond NNS cord-294218-v4gjabp3 194 30 to to TO cord-294218-v4gjabp3 194 31 yield yield VB cord-294218-v4gjabp3 194 32 gp gp NNP cord-294218-v4gjabp3 194 33 130 130 CD cord-294218-v4gjabp3 194 34 , , , cord-294218-v4gjabp3 194 35 as as IN cord-294218-v4gjabp3 194 36 suggested suggest VBN cord-294218-v4gjabp3 194 37 by by IN cord-294218-v4gjabp3 194 38 electrophoresis electrophoresis NN cord-294218-v4gjabp3 194 39 in in IN cord-294218-v4gjabp3 194 40 the the DT cord-294218-v4gjabp3 194 41 presence presence NN cord-294218-v4gjabp3 194 42 of of IN cord-294218-v4gjabp3 194 43 2-ME 2-me CD cord-294218-v4gjabp3 194 44 . . . cord-294218-v4gjabp3 195 1 A a DT cord-294218-v4gjabp3 195 2 further further JJ cord-294218-v4gjabp3 195 3 glycosylation glycosylation NN cord-294218-v4gjabp3 195 4 step step NN cord-294218-v4gjabp3 195 5 would would MD cord-294218-v4gjabp3 195 6 result result VB cord-294218-v4gjabp3 195 7 to to IN cord-294218-v4gjabp3 195 8 the the DT cord-294218-v4gjabp3 195 9 final final JJ cord-294218-v4gjabp3 195 10 E3 E3 NNP cord-294218-v4gjabp3 195 11 protein protein NN cord-294218-v4gjabp3 195 12 , , , cord-294218-v4gjabp3 195 13 as as IN cord-294218-v4gjabp3 195 14 described describe VBN cord-294218-v4gjabp3 195 15 for for IN cord-294218-v4gjabp3 195 16 BCV BCV NNP cord-294218-v4gjabp3 195 17 [ [ -LRB- cord-294218-v4gjabp3 195 18 9 9 CD cord-294218-v4gjabp3 195 19 , , , cord-294218-v4gjabp3 195 20 10 10 CD cord-294218-v4gjabp3 195 21 ] ] -RRB- cord-294218-v4gjabp3 195 22 . . . cord-294218-v4gjabp3 196 1 The the DT cord-294218-v4gjabp3 196 2 fact fact NN cord-294218-v4gjabp3 196 3 that that IN cord-294218-v4gjabp3 196 4 E e NN cord-294218-v4gjabp3 196 5 1 1 CD cord-294218-v4gjabp3 196 6 was be VBD cord-294218-v4gjabp3 196 7 not not RB cord-294218-v4gjabp3 196 8 detected detect VBN cord-294218-v4gjabp3 196 9 in in IN cord-294218-v4gjabp3 196 10 lysates lysate NNS cord-294218-v4gjabp3 196 11 of of IN cord-294218-v4gjabp3 196 12 methionine methionine NNP cord-294218-v4gjabp3 196 13 labeled label VBN cord-294218-v4gjabp3 196 14 TCVinfected TCVinfected NNP cord-294218-v4gjabp3 196 15 , , , cord-294218-v4gjabp3 196 16 TM TM NNP cord-294218-v4gjabp3 196 17 - - HYPH cord-294218-v4gjabp3 196 18 treated treat VBN cord-294218-v4gjabp3 196 19 cells cell NNS cord-294218-v4gjabp3 196 20 , , , cord-294218-v4gjabp3 196 21 is be VBZ cord-294218-v4gjabp3 196 22 suggestive suggestive JJ cord-294218-v4gjabp3 196 23 of of IN cord-294218-v4gjabp3 196 24 a a DT cord-294218-v4gjabp3 196 25 N n CD cord-294218-v4gjabp3 196 26 - - HYPH cord-294218-v4gjabp3 196 27 linked link VBN cord-294218-v4gjabp3 196 28 glycosylation glycosylation NN cord-294218-v4gjabp3 196 29 . . . cord-294218-v4gjabp3 197 1 The the DT cord-294218-v4gjabp3 197 2 absence absence NN cord-294218-v4gjabp3 197 3 in in IN cord-294218-v4gjabp3 197 4 the the DT cord-294218-v4gjabp3 197 5 same same JJ cord-294218-v4gjabp3 197 6 gel gel NN cord-294218-v4gjabp3 197 7 of of IN cord-294218-v4gjabp3 197 8 the the DT cord-294218-v4gjabp3 197 9 36 36 CD cord-294218-v4gjabp3 197 10 - - SYM cord-294218-v4gjabp3 197 11 42,000 42,000 CD cord-294218-v4gjabp3 197 12 mol.wt mol.wt NNP cord-294218-v4gjabp3 197 13 , , , cord-294218-v4gjabp3 197 14 species specie NNS cord-294218-v4gjabp3 197 15 , , , cord-294218-v4gjabp3 197 16 probably probably RB cord-294218-v4gjabp3 197 17 corresponding correspond VBG cord-294218-v4gjabp3 197 18 to to IN cord-294218-v4gjabp3 197 19 an an DT cord-294218-v4gjabp3 197 20 aggregated aggregated JJ cord-294218-v4gjabp3 197 21 form form NN cord-294218-v4gjabp3 197 22 of of IN cord-294218-v4gjabp3 197 23 E1 E1 NNP cord-294218-v4gjabp3 197 24 [ [ -LRB- cord-294218-v4gjabp3 197 25 10 10 CD cord-294218-v4gjabp3 197 26 , , , cord-294218-v4gjabp3 197 27 15 15 CD cord-294218-v4gjabp3 197 28 , , , cord-294218-v4gjabp3 197 29 38 38 CD cord-294218-v4gjabp3 197 30 , , , cord-294218-v4gjabp3 197 31 39 39 CD cord-294218-v4gjabp3 197 32 ] ] -RRB- cord-294218-v4gjabp3 197 33 , , , cord-294218-v4gjabp3 197 34 and and CC cord-294218-v4gjabp3 197 35 the the DT cord-294218-v4gjabp3 197 36 presence presence NN cord-294218-v4gjabp3 197 37 of of IN cord-294218-v4gjabp3 197 38 E1 E1 NNP cord-294218-v4gjabp3 197 39 in in IN cord-294218-v4gjabp3 197 40 lysates lysate NNS cord-294218-v4gjabp3 197 41 of of IN cord-294218-v4gjabp3 197 42 TCV TCV NNP cord-294218-v4gjabp3 197 43 - - HYPH cord-294218-v4gjabp3 197 44 infected infect VBN cord-294218-v4gjabp3 197 45 , , , cord-294218-v4gjabp3 197 46 SM sm NN cord-294218-v4gjabp3 197 47 - - HYPH cord-294218-v4gjabp3 197 48 treated treat VBN cord-294218-v4gjabp3 197 49 cells cell NNS cord-294218-v4gjabp3 197 50 , , , cord-294218-v4gjabp3 197 51 further further RB cord-294218-v4gjabp3 197 52 supported support VBD cord-294218-v4gjabp3 197 53 this this DT cord-294218-v4gjabp3 197 54 notion notion NN cord-294218-v4gjabp3 197 55 . . . cord-294218-v4gjabp3 198 1 In in IN cord-294218-v4gjabp3 198 2 this this DT cord-294218-v4gjabp3 198 3 respect respect NN cord-294218-v4gjabp3 198 4 , , , cord-294218-v4gjabp3 198 5 TCV TCV NNP cord-294218-v4gjabp3 198 6 differs differ VBZ cord-294218-v4gjabp3 198 7 from from IN cord-294218-v4gjabp3 198 8 viruses virus NNS cord-294218-v4gjabp3 198 9 of of IN cord-294218-v4gjabp3 198 10 the the DT cord-294218-v4gjabp3 198 11 subgroup subgroup NN cord-294218-v4gjabp3 198 12 of of IN cord-294218-v4gjabp3 198 13 mammalian mammalian JJ cord-294218-v4gjabp3 198 14 hemagglutinating hemagglutinating NNP cord-294218-v4gjabp3 198 15 coronaviruses coronaviruse NNS cord-294218-v4gjabp3 198 16 [ [ -LRB- cord-294218-v4gjabp3 198 17 9 9 CD cord-294218-v4gjabp3 198 18 , , , cord-294218-v4gjabp3 198 19 18 18 CD cord-294218-v4gjabp3 198 20 ] ] -RRB- cord-294218-v4gjabp3 198 21 , , , cord-294218-v4gjabp3 198 22 but but CC cord-294218-v4gjabp3 198 23 resembles resemble VBZ cord-294218-v4gjabp3 198 24 IBV IBV NNP cord-294218-v4gjabp3 198 25 [ [ -LRB- cord-294218-v4gjabp3 198 26 2 2 CD cord-294218-v4gjabp3 198 27 , , , cord-294218-v4gjabp3 198 28 3 3 CD cord-294218-v4gjabp3 198 29 , , , cord-294218-v4gjabp3 198 30 37 37 CD cord-294218-v4gjabp3 198 31 ] ] -RRB- cord-294218-v4gjabp3 198 32 . . . cord-294218-v4gjabp3 199 1 Whereas whereas IN cord-294218-v4gjabp3 199 2 glycosylation glycosylation NN cord-294218-v4gjabp3 199 3 of of IN cord-294218-v4gjabp3 199 4 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 199 5 with with IN cord-294218-v4gjabp3 199 6 N n CD cord-294218-v4gjabp3 199 7 - - HYPH cord-294218-v4gjabp3 199 8 glycosidic glycosidic JJ cord-294218-v4gjabp3 199 9 linkages linkage NNS cord-294218-v4gjabp3 199 10 is be VBZ cord-294218-v4gjabp3 199 11 generally generally RB cord-294218-v4gjabp3 199 12 initiated initiate VBN cord-294218-v4gjabp3 199 13 at at IN cord-294218-v4gjabp3 199 14 the the DT cord-294218-v4gjabp3 199 15 co co JJ cord-294218-v4gjabp3 199 16 - - JJ cord-294218-v4gjabp3 199 17 translational translational JJ cord-294218-v4gjabp3 199 18 level level NN cord-294218-v4gjabp3 199 19 , , , cord-294218-v4gjabp3 199 20 glycosylation glycosylation NN cord-294218-v4gjabp3 199 21 of of IN cord-294218-v4gjabp3 199 22 E e NN cord-294218-v4gjabp3 199 23 1 1 CD cord-294218-v4gjabp3 199 24 of of IN cord-294218-v4gjabp3 199 25 TCV TCV NNP cord-294218-v4gjabp3 199 26 appears appear VBZ cord-294218-v4gjabp3 199 27 to to TO cord-294218-v4gjabp3 199 28 be be VB cord-294218-v4gjabp3 199 29 exclusively exclusively RB cord-294218-v4gjabp3 199 30 a a DT cord-294218-v4gjabp3 199 31 posttranslational posttranslational JJ cord-294218-v4gjabp3 199 32 event event NN cord-294218-v4gjabp3 199 33 . . . cord-294218-v4gjabp3 200 1 This this DT cord-294218-v4gjabp3 200 2 is be VBZ cord-294218-v4gjabp3 200 3 suggested suggest VBN cord-294218-v4gjabp3 200 4 by by IN cord-294218-v4gjabp3 200 5 the the DT cord-294218-v4gjabp3 200 6 observation observation NN cord-294218-v4gjabp3 200 7 that that WDT cord-294218-v4gjabp3 200 8 apoprotein apoprotein NNP cord-294218-v4gjabp3 200 9 precursor precursor NN cord-294218-v4gjabp3 200 10 of of IN cord-294218-v4gjabp3 200 11 E e NN cord-294218-v4gjabp3 200 12 1 1 CD cord-294218-v4gjabp3 200 13 ( ( -LRB- cord-294218-v4gjabp3 200 14 p20 p20 NN cord-294218-v4gjabp3 200 15 ) ) -RRB- cord-294218-v4gjabp3 200 16 was be VBD cord-294218-v4gjabp3 200 17 present present JJ cord-294218-v4gjabp3 200 18 in in IN cord-294218-v4gjabp3 200 19 TCV TCV NNP cord-294218-v4gjabp3 200 20 - - HYPH cord-294218-v4gjabp3 200 21 infected infect VBN cord-294218-v4gjabp3 200 22 cells cell NNS cord-294218-v4gjabp3 200 23 prior prior RB cord-294218-v4gjabp3 200 24 gp24 gp24 NNP cord-294218-v4gjabp3 200 25 . . . cord-294218-v4gjabp3 201 1 For for IN cord-294218-v4gjabp3 201 2 TCV TCV NNP cord-294218-v4gjabp3 201 3 and and CC cord-294218-v4gjabp3 201 4 IBV IBV NNP cord-294218-v4gjabp3 201 5 , , , cord-294218-v4gjabp3 201 6 E e NN cord-294218-v4gjabp3 201 7 1 1 CD cord-294218-v4gjabp3 201 8 therefore therefore RB cord-294218-v4gjabp3 201 9 constitutes constitute VBZ cord-294218-v4gjabp3 201 10 an an DT cord-294218-v4gjabp3 201 11 example example NN cord-294218-v4gjabp3 201 12 of of IN cord-294218-v4gjabp3 201 13 a a DT cord-294218-v4gjabp3 201 14 membrane membrane NN cord-294218-v4gjabp3 201 15 glycoprotein glycoprotein NN cord-294218-v4gjabp3 201 16 that that WDT cord-294218-v4gjabp3 201 17 is be VBZ cord-294218-v4gjabp3 201 18 targeted target VBN cord-294218-v4gjabp3 201 19 to to IN cord-294218-v4gjabp3 201 20 the the DT cord-294218-v4gjabp3 201 21 ER ER NNP cord-294218-v4gjabp3 201 22 and and CC cord-294218-v4gjabp3 201 23 is be VBZ cord-294218-v4gjabp3 201 24 not not RB cord-294218-v4gjabp3 201 25 subsequently subsequently RB cord-294218-v4gjabp3 201 26 directed direct VBN cord-294218-v4gjabp3 201 27 further far RBR cord-294218-v4gjabp3 201 28 along along IN cord-294218-v4gjabp3 201 29 the the DT cord-294218-v4gjabp3 201 30 secretory secretory JJ cord-294218-v4gjabp3 201 31 pathway pathway NN cord-294218-v4gjabp3 201 32 . . . cord-294218-v4gjabp3 202 1 As as IN cord-294218-v4gjabp3 202 2 previously previously RB cord-294218-v4gjabp3 202 3 reported report VBN cord-294218-v4gjabp3 202 4 for for IN cord-294218-v4gjabp3 202 5 IBV IBV NNP cord-294218-v4gjabp3 202 6 and and CC cord-294218-v4gjabp3 202 7 MHV MHV NNP cord-294218-v4gjabp3 202 8 [ [ -LRB- cord-294218-v4gjabp3 202 9 3 3 CD cord-294218-v4gjabp3 202 10 , , , cord-294218-v4gjabp3 202 11 16 16 CD cord-294218-v4gjabp3 202 12 , , , cord-294218-v4gjabp3 202 13 37 37 CD cord-294218-v4gjabp3 202 14 ] ] -RRB- cord-294218-v4gjabp3 202 15 , , , cord-294218-v4gjabp3 202 16 E e NN cord-294218-v4gjabp3 202 17 1 1 CD cord-294218-v4gjabp3 202 18 appeared appear VBD cord-294218-v4gjabp3 202 19 to to TO cord-294218-v4gjabp3 202 20 be be VB cord-294218-v4gjabp3 202 21 the the DT cord-294218-v4gjabp3 202 22 only only JJ cord-294218-v4gjabp3 202 23 glycoprotein glycoprotein NN cord-294218-v4gjabp3 202 24 required require VBN cord-294218-v4gjabp3 202 25 for for IN cord-294218-v4gjabp3 202 26 the the DT cord-294218-v4gjabp3 202 27 formation formation NN cord-294218-v4gjabp3 202 28 of of IN cord-294218-v4gjabp3 202 29 TCV TCV NNP cord-294218-v4gjabp3 202 30 virions virion NNS cord-294218-v4gjabp3 202 31 , , , cord-294218-v4gjabp3 202 32 and and CC cord-294218-v4gjabp3 202 33 its -PRON- PRP$ cord-294218-v4gjabp3 202 34 glycosylation glycosylation NN cord-294218-v4gjabp3 202 35 is be VBZ cord-294218-v4gjabp3 202 36 apparently apparently RB cord-294218-v4gjabp3 202 37 not not RB cord-294218-v4gjabp3 202 38 essential essential JJ cord-294218-v4gjabp3 202 39 [ [ -LRB- cord-294218-v4gjabp3 202 40 3 3 CD cord-294218-v4gjabp3 202 41 , , , cord-294218-v4gjabp3 202 42 37 37 CD cord-294218-v4gjabp3 202 43 ] ] -RRB- cord-294218-v4gjabp3 202 44 . . . cord-294218-v4gjabp3 203 1 Arrest arrest NN cord-294218-v4gjabp3 203 2 of of IN cord-294218-v4gjabp3 203 3 virus virus NN cord-294218-v4gjabp3 203 4 budding bud VBG cord-294218-v4gjabp3 203 5 , , , cord-294218-v4gjabp3 203 6 as as IN cord-294218-v4gjabp3 203 7 demonstrated demonstrate VBN cord-294218-v4gjabp3 203 8 in in IN cord-294218-v4gjabp3 203 9 MHV MHV NNP cord-294218-v4gjabp3 203 10 - - HYPH cord-294218-v4gjabp3 203 11 infected infect VBN cord-294218-v4gjabp3 203 12 cells cell NNS cord-294218-v4gjabp3 203 13 cultivated cultivate VBN cord-294218-v4gjabp3 203 14 in in IN cord-294218-v4gjabp3 203 15 the the DT cord-294218-v4gjabp3 203 16 presence presence NN cord-294218-v4gjabp3 203 17 of of IN cord-294218-v4gjabp3 203 18 monensin monensin NNP cord-294218-v4gjabp3 203 19 [ [ -LRB- cord-294218-v4gjabp3 203 20 23 23 CD cord-294218-v4gjabp3 203 21 ] ] -RRB- cord-294218-v4gjabp3 203 22 , , , cord-294218-v4gjabp3 203 23 was be VBD cord-294218-v4gjabp3 203 24 not not RB cord-294218-v4gjabp3 203 25 demonstrated demonstrate VBN cord-294218-v4gjabp3 203 26 in in IN cord-294218-v4gjabp3 203 27 TCV TCV NNP cord-294218-v4gjabp3 203 28 - - HYPH cord-294218-v4gjabp3 203 29 infected infect VBN cord-294218-v4gjabp3 203 30 cells cell NNS cord-294218-v4gjabp3 203 31 in in IN cord-294218-v4gjabp3 203 32 the the DT cord-294218-v4gjabp3 203 33 presence presence NN cord-294218-v4gjabp3 203 34 of of IN cord-294218-v4gjabp3 203 35 TM TM NNP cord-294218-v4gjabp3 203 36 . . . cord-294218-v4gjabp3 204 1 This this DT cord-294218-v4gjabp3 204 2 strengthens strengthen VBZ cord-294218-v4gjabp3 204 3 the the DT cord-294218-v4gjabp3 204 4 notion notion NN cord-294218-v4gjabp3 204 5 that that IN cord-294218-v4gjabp3 204 6 glycosylation glycosylation NN cord-294218-v4gjabp3 204 7 of of IN cord-294218-v4gjabp3 204 8 E e NN cord-294218-v4gjabp3 204 9 1 1 CD cord-294218-v4gjabp3 204 10 is be VBZ cord-294218-v4gjabp3 204 11 not not RB cord-294218-v4gjabp3 204 12 necessary necessary JJ cord-294218-v4gjabp3 204 13 for for IN cord-294218-v4gjabp3 204 14 virus virus NN cord-294218-v4gjabp3 204 15 budding bud VBG cord-294218-v4gjabp3 204 16 . . . cord-294218-v4gjabp3 205 1 Cloning clone VBG cord-294218-v4gjabp3 205 2 and and CC cord-294218-v4gjabp3 205 3 sequencing sequencing NN cord-294218-v4gjabp3 205 4 of of IN cord-294218-v4gjabp3 205 5 the the DT cord-294218-v4gjabp3 205 6 gene gene NN cord-294218-v4gjabp3 205 7 encoding encode VBG cord-294218-v4gjabp3 205 8 the the DT cord-294218-v4gjabp3 205 9 spike spike NN cord-294218-v4gjabp3 205 10 protein protein NN cord-294218-v4gjabp3 205 11 of of IN cord-294218-v4gjabp3 205 12 the the DT cord-294218-v4gjabp3 205 13 coronavirus coronavirus NN cord-294218-v4gjabp3 205 14 IBV IBV NNP cord-294218-v4gjabp3 205 15 Sequence sequence NN cord-294218-v4gjabp3 205 16 of of IN cord-294218-v4gjabp3 205 17 the the DT cord-294218-v4gjabp3 205 18 membrane membrane NN cord-294218-v4gjabp3 205 19 protein protein NN cord-294218-v4gjabp3 205 20 gene gene NN cord-294218-v4gjabp3 205 21 from from IN cord-294218-v4gjabp3 205 22 avian avian JJ cord-294218-v4gjabp3 205 23 coronavirus coronavirus NN cord-294218-v4gjabp3 205 24 IBV IBV NNP cord-294218-v4gjabp3 205 25 Coronavirus Coronavirus NNP cord-294218-v4gjabp3 205 26 IBV IBV NNP cord-294218-v4gjabp3 205 27 glycopolypeptides glycopolypeptide NNS cord-294218-v4gjabp3 205 28 : : : cord-294218-v4gjabp3 205 29 size size NN cord-294218-v4gjabp3 205 30 of of IN cord-294218-v4gjabp3 205 31 their -PRON- PRP$ cord-294218-v4gjabp3 205 32 polypeptide polypeptide NN cord-294218-v4gjabp3 205 33 moieties moiety NNS cord-294218-v4gjabp3 205 34 and and CC cord-294218-v4gjabp3 205 35 nature nature NN cord-294218-v4gjabp3 205 36 of of IN cord-294218-v4gjabp3 205 37 their -PRON- PRP$ cord-294218-v4gjabp3 205 38 oligosaccharides oligosaccharide NNS cord-294218-v4gjabp3 205 39 Coronavirus Coronavirus NNP cord-294218-v4gjabp3 205 40 associated associate VBN cord-294218-v4gjabp3 205 41 with with IN cord-294218-v4gjabp3 205 42 outbreaks outbreak NNS cord-294218-v4gjabp3 205 43 of of IN cord-294218-v4gjabp3 205 44 transmissible transmissible JJ cord-294218-v4gjabp3 205 45 enteritis enteritis NN cord-294218-v4gjabp3 205 46 ( ( -LRB- cord-294218-v4gjabp3 205 47 Bluecomb Bluecomb NNP cord-294218-v4gjabp3 205 48 ) ) -RRB- cord-294218-v4gjabp3 205 49 of of IN cord-294218-v4gjabp3 205 50 turkeys turkey NNS cord-294218-v4gjabp3 205 51 in in IN cord-294218-v4gjabp3 205 52 Quebec Quebec NNP cord-294218-v4gjabp3 205 53 ; ; : cord-294218-v4gjabp3 205 54 hemagglutination hemagglutination NN cord-294218-v4gjabp3 205 55 properties property NNS cord-294218-v4gjabp3 205 56 and and CC cord-294218-v4gjabp3 205 57 cell cell NN cord-294218-v4gjabp3 205 58 cultivation cultivation NN cord-294218-v4gjabp3 205 59 Viral viral JJ cord-294218-v4gjabp3 205 60 agents agent NNS cord-294218-v4gjabp3 205 61 associated associate VBN cord-294218-v4gjabp3 205 62 with with IN cord-294218-v4gjabp3 205 63 outbreaks outbreak NNS cord-294218-v4gjabp3 205 64 of of IN cord-294218-v4gjabp3 205 65 diarrhea diarrhea NN cord-294218-v4gjabp3 205 66 in in IN cord-294218-v4gjabp3 205 67 turkey turkey NN cord-294218-v4gjabp3 205 68 flocks flock NNS cord-294218-v4gjabp3 205 69 in in IN cord-294218-v4gjabp3 205 70 Quebec Quebec NNP cord-294218-v4gjabp3 205 71 Identification Identification NNP cord-294218-v4gjabp3 205 72 of of IN cord-294218-v4gjabp3 205 73 the the DT cord-294218-v4gjabp3 205 74 structural structural JJ cord-294218-v4gjabp3 205 75 proteins protein NNS cord-294218-v4gjabp3 205 76 of of IN cord-294218-v4gjabp3 205 77 turkey turkey NN cord-294218-v4gjabp3 205 78 enteric enteric JJ cord-294218-v4gjabp3 205 79 coronavirus coronavirus NN cord-294218-v4gjabp3 205 80 Isolation isolation NN cord-294218-v4gjabp3 205 81 and and CC cord-294218-v4gjabp3 205 82 trypsin trypsin NN cord-294218-v4gjabp3 205 83 - - HYPH cord-294218-v4gjabp3 205 84 enhanced enhance VBN cord-294218-v4gjabp3 205 85 propagation propagation NN cord-294218-v4gjabp3 205 86 of of IN cord-294218-v4gjabp3 205 87 turkey turkey NN cord-294218-v4gjabp3 205 88 enteric enteric JJ cord-294218-v4gjabp3 205 89 ( ( -LRB- cord-294218-v4gjabp3 205 90 Bluecomb Bluecomb NNP cord-294218-v4gjabp3 205 91 ) ) -RRB- cord-294218-v4gjabp3 205 92 coronaviruses coronaviruse VBZ cord-294218-v4gjabp3 205 93 in in IN cord-294218-v4gjabp3 205 94 a a DT cord-294218-v4gjabp3 205 95 continuous continuous JJ cord-294218-v4gjabp3 205 96 human human JJ cord-294218-v4gjabp3 205 97 rectal rectal JJ cord-294218-v4gjabp3 205 98 tumor tumor NN cord-294218-v4gjabp3 205 99 ( ( -LRB- cord-294218-v4gjabp3 205 100 HRT-18 HRT-18 NNP cord-294218-v4gjabp3 205 101 ) ) -RRB- cord-294218-v4gjabp3 205 102 cell cell NN cord-294218-v4gjabp3 205 103 line line NN cord-294218-v4gjabp3 205 104 Identification identification NN cord-294218-v4gjabp3 205 105 of of IN cord-294218-v4gjabp3 205 106 putative putative JJ cord-294218-v4gjabp3 205 107 gene gene NN cord-294218-v4gjabp3 205 108 products product NNS cord-294218-v4gjabp3 205 109 in in IN cord-294218-v4gjabp3 205 110 cells cell NNS cord-294218-v4gjabp3 205 111 infected infect VBN cord-294218-v4gjabp3 205 112 with with IN cord-294218-v4gjabp3 205 113 murine murine JJ cord-294218-v4gjabp3 205 114 coronavirus coronavirus NN cord-294218-v4gjabp3 205 115 A59 A59 NNP cord-294218-v4gjabp3 205 116 Structural structural JJ cord-294218-v4gjabp3 205 117 proteins protein NNS cord-294218-v4gjabp3 205 118 of of IN cord-294218-v4gjabp3 205 119 bovine bovine JJ cord-294218-v4gjabp3 205 120 coronavirus coronavirus NN cord-294218-v4gjabp3 205 121 and and CC cord-294218-v4gjabp3 205 122 their -PRON- PRP$ cord-294218-v4gjabp3 205 123 intracellular intracellular JJ cord-294218-v4gjabp3 205 124 processing processing NN cord-294218-v4gjabp3 205 125 Monoclonal monoclonal JJ cord-294218-v4gjabp3 205 126 antibodies antibody NNS cord-294218-v4gjabp3 205 127 to to IN cord-294218-v4gjabp3 205 128 bovine bovine JJ cord-294218-v4gjabp3 205 129 coronavirus coronavirus NN cord-294218-v4gjabp3 205 130 : : : cord-294218-v4gjabp3 205 131 characteristics characteristic NNS cord-294218-v4gjabp3 205 132 and and CC cord-294218-v4gjabp3 205 133 topographical topographical JJ cord-294218-v4gjabp3 205 134 mapping mapping NN cord-294218-v4gjabp3 205 135 of of IN cord-294218-v4gjabp3 205 136 neutralizing neutralize VBG cord-294218-v4gjabp3 205 137 epitopes epitope NNS cord-294218-v4gjabp3 205 138 on on IN cord-294218-v4gjabp3 205 139 the the DT cord-294218-v4gjabp3 205 140 E2 E2 NNP cord-294218-v4gjabp3 205 141 and and CC cord-294218-v4gjabp3 206 1 E3 E3 NNP cord-294218-v4gjabp3 206 2 glycoproteins glycoprotein VBZ cord-294218-v4gjabp3 206 3 A a DT cord-294218-v4gjabp3 206 4 routine routine JJ cord-294218-v4gjabp3 206 5 technique technique NN cord-294218-v4gjabp3 206 6 for for IN cord-294218-v4gjabp3 206 7 double double RB cord-294218-v4gjabp3 206 8 - - HYPH cord-294218-v4gjabp3 206 9 staining stain VBG cord-294218-v4gjabp3 206 10 ultra ultra JJ cord-294218-v4gjabp3 206 11 - - JJ cord-294218-v4gjabp3 206 12 thin thin JJ cord-294218-v4gjabp3 206 13 sections section NNS cord-294218-v4gjabp3 206 14 using use VBG cord-294218-v4gjabp3 206 15 uranyl uranyl JJ cord-294218-v4gjabp3 206 16 and and CC cord-294218-v4gjabp3 206 17 lead lead VB cord-294218-v4gjabp3 206 18 salts salt NNS cord-294218-v4gjabp3 206 19 Proteolytic proteolytic JJ cord-294218-v4gjabp3 206 20 cleavage cleavage NN cord-294218-v4gjabp3 206 21 of of IN cord-294218-v4gjabp3 206 22 E2 E2 NNP cord-294218-v4gjabp3 206 23 glycoprotein glycoprotein NN cord-294218-v4gjabp3 206 24 of of IN cord-294218-v4gjabp3 206 25 murine murine JJ cord-294218-v4gjabp3 206 26 coronavirus coronavirus NN cord-294218-v4gjabp3 206 27 : : : cord-294218-v4gjabp3 206 28 host host NN cord-294218-v4gjabp3 206 29 - - HYPH cord-294218-v4gjabp3 206 30 dependent dependent JJ cord-294218-v4gjabp3 206 31 differences difference NNS cord-294218-v4gjabp3 206 32 in in IN cord-294218-v4gjabp3 206 33 proteolytic proteolytic JJ cord-294218-v4gjabp3 206 34 cleavage cleavage NN cord-294218-v4gjabp3 206 35 and and CC cord-294218-v4gjabp3 206 36 cell cell NN cord-294218-v4gjabp3 206 37 fusion fusion NN cord-294218-v4gjabp3 206 38 What what WP cord-294218-v4gjabp3 206 39 regulates regulate VBZ cord-294218-v4gjabp3 206 40 secretion secretion NN cord-294218-v4gjabp3 206 41 of of IN cord-294218-v4gjabp3 206 42 non non JJ cord-294218-v4gjabp3 206 43 - - JJ cord-294218-v4gjabp3 206 44 stored store VBN cord-294218-v4gjabp3 206 45 proteins protein NNS cord-294218-v4gjabp3 206 46 by by IN cord-294218-v4gjabp3 206 47 eukaryotic eukaryotic JJ cord-294218-v4gjabp3 206 48 cells cell NNS cord-294218-v4gjabp3 206 49 ? ? . cord-294218-v4gjabp3 207 1 Expression expression NN cord-294218-v4gjabp3 207 2 of of IN cord-294218-v4gjabp3 207 3 wild wild JJ cord-294218-v4gjabp3 207 4 - - HYPH cord-294218-v4gjabp3 207 5 type type NN cord-294218-v4gjabp3 207 6 and and CC cord-294218-v4gjabp3 207 7 mutant mutant JJ cord-294218-v4gjabp3 207 8 forms form NNS cord-294218-v4gjabp3 207 9 of of IN cord-294218-v4gjabp3 207 10 influenza influenza NN cord-294218-v4gjabp3 207 11 hemagglutinin hemagglutinin NN cord-294218-v4gjabp3 207 12 : : : cord-294218-v4gjabp3 207 13 the the DT cord-294218-v4gjabp3 207 14 role role NN cord-294218-v4gjabp3 207 15 of of IN cord-294218-v4gjabp3 207 16 folding fold VBG cord-294218-v4gjabp3 207 17 in in IN cord-294218-v4gjabp3 207 18 intracellular intracellular JJ cord-294218-v4gjabp3 207 19 transport transport NN cord-294218-v4gjabp3 207 20 Structural structural JJ cord-294218-v4gjabp3 207 21 proteins protein NNS cord-294218-v4gjabp3 207 22 of of IN cord-294218-v4gjabp3 207 23 human human JJ cord-294218-v4gjabp3 207 24 respiratory respiratory JJ cord-294218-v4gjabp3 207 25 coronavirus coronavirus NN cord-294218-v4gjabp3 207 26 OC43 OC43 NNP cord-294218-v4gjabp3 207 27 Tunicamycin Tunicamycin NNP cord-294218-v4gjabp3 207 28 resistant resistant JJ cord-294218-v4gjabp3 207 29 glycosylation glycosylation NN cord-294218-v4gjabp3 207 30 of of IN cord-294218-v4gjabp3 207 31 a a DT cord-294218-v4gjabp3 207 32 coronavirus coronavirus NN cord-294218-v4gjabp3 207 33 glycoprotein glycoprotein NN cord-294218-v4gjabp3 207 34 : : : cord-294218-v4gjabp3 207 35 demonstration demonstration NN cord-294218-v4gjabp3 207 36 of of IN cord-294218-v4gjabp3 207 37 a a DT cord-294218-v4gjabp3 207 38 novel novel JJ cord-294218-v4gjabp3 207 39 type type NN cord-294218-v4gjabp3 207 40 of of IN cord-294218-v4gjabp3 207 41 viral viral JJ cord-294218-v4gjabp3 207 42 glycoprotein glycoprotein NN cord-294218-v4gjabp3 207 43 Bovine bovine JJ cord-294218-v4gjabp3 207 44 coronavirus coronavirus NN cord-294218-v4gjabp3 207 45 hemagglutinin hemagglutinin NN cord-294218-v4gjabp3 207 46 protein protein NN cord-294218-v4gjabp3 207 47 Sequence Sequence NNP cord-294218-v4gjabp3 207 48 analysis analysis NN cord-294218-v4gjabp3 207 49 of of IN cord-294218-v4gjabp3 207 50 the the DT cord-294218-v4gjabp3 207 51 bovine bovine JJ cord-294218-v4gjabp3 207 52 coronavirus coronavirus NN cord-294218-v4gjabp3 207 53 nucleocapsid nucleocapsid NN cord-294218-v4gjabp3 207 54 and and CC cord-294218-v4gjabp3 207 55 matrix matrix NN cord-294218-v4gjabp3 207 56 protein protein NN cord-294218-v4gjabp3 207 57 genes gene NNS cord-294218-v4gjabp3 207 58 Sequence Sequence NNP cord-294218-v4gjabp3 207 59 and and CC cord-294218-v4gjabp3 207 60 N n CD cord-294218-v4gjabp3 207 61 - - HYPH cord-294218-v4gjabp3 207 62 terminal terminal NN cord-294218-v4gjabp3 207 63 processing processing NN cord-294218-v4gjabp3 207 64 of of IN cord-294218-v4gjabp3 207 65 the the DT cord-294218-v4gjabp3 207 66 transmembrane transmembrane NN cord-294218-v4gjabp3 207 67 protein protein NN cord-294218-v4gjabp3 207 68 E E NNP cord-294218-v4gjabp3 207 69 1 1 CD cord-294218-v4gjabp3 207 70 of of IN cord-294218-v4gjabp3 207 71 the the DT cord-294218-v4gjabp3 207 72 coronavirus coronavirus NN cord-294218-v4gjabp3 207 73 transmissible transmissible JJ cord-294218-v4gjabp3 207 74 gastroenteritis gastroenteritis NN cord-294218-v4gjabp3 207 75 virus virus NN cord-294218-v4gjabp3 207 76 Primary primary JJ cord-294218-v4gjabp3 207 77 structure structure NN cord-294218-v4gjabp3 207 78 of of IN cord-294218-v4gjabp3 207 79 the the DT cord-294218-v4gjabp3 207 80 glycoprotein glycoprotein NN cord-294218-v4gjabp3 207 81 E2 e2 NN cord-294218-v4gjabp3 207 82 of of IN cord-294218-v4gjabp3 207 83 coronavirus coronavirus NN cord-294218-v4gjabp3 207 84 MHV MHV NNP cord-294218-v4gjabp3 207 85 - - HYPH cord-294218-v4gjabp3 207 86 A59 A59 NNP cord-294218-v4gjabp3 207 87 and and CC cord-294218-v4gjabp3 207 88 identification identification NN cord-294218-v4gjabp3 207 89 of of IN cord-294218-v4gjabp3 207 90 the the DT cord-294218-v4gjabp3 207 91 trypsin trypsin NN cord-294218-v4gjabp3 207 92 cleavage cleavage NN cord-294218-v4gjabp3 207 93 site site NN cord-294218-v4gjabp3 207 94 Purification purification NN cord-294218-v4gjabp3 207 95 and and CC cord-294218-v4gjabp3 207 96 concentration concentration NN cord-294218-v4gjabp3 207 97 of of IN cord-294218-v4gjabp3 207 98 viruses virus NNS cord-294218-v4gjabp3 207 99 associated associate VBN cord-294218-v4gjabp3 207 100 with with IN cord-294218-v4gjabp3 207 101 transmissible transmissible JJ cord-294218-v4gjabp3 207 102 ( ( -LRB- cord-294218-v4gjabp3 207 103 coronaviral coronaviral JJ cord-294218-v4gjabp3 207 104 ) ) -RRB- cord-294218-v4gjabp3 207 105 enteritis enteritis NN cord-294218-v4gjabp3 207 106 of of IN cord-294218-v4gjabp3 207 107 turkeys turkey NNS cord-294218-v4gjabp3 208 1 ( ( -LRB- cord-294218-v4gjabp3 208 2 Bluecomb Bluecomb NNP cord-294218-v4gjabp3 208 3 ) ) -RRB- cord-294218-v4gjabp3 208 4 Coronavirus Coronavirus NNP cord-294218-v4gjabp3 208 5 glycoprotein glycoprotein NN cord-294218-v4gjabp3 208 6 E e NN cord-294218-v4gjabp3 208 7 1 1 CD cord-294218-v4gjabp3 208 8 , , , cord-294218-v4gjabp3 208 9 a a DT cord-294218-v4gjabp3 208 10 new new JJ cord-294218-v4gjabp3 208 11 type type NN cord-294218-v4gjabp3 208 12 of of IN cord-294218-v4gjabp3 208 13 viral viral JJ cord-294218-v4gjabp3 208 14 glycoprotein glycoprotein NN cord-294218-v4gjabp3 208 15 Posttranslational posttranslational JJ cord-294218-v4gjabp3 208 16 glycosylation glycosylation NN cord-294218-v4gjabp3 208 17 of of IN cord-294218-v4gjabp3 208 18 coronavirus coronavirus NN cord-294218-v4gjabp3 208 19 glycoprotein glycoprotein NN cord-294218-v4gjabp3 208 20 E e NN cord-294218-v4gjabp3 208 21 1 1 CD cord-294218-v4gjabp3 208 22 : : : cord-294218-v4gjabp3 208 23 inhibition inhibition NN cord-294218-v4gjabp3 208 24 by by IN cord-294218-v4gjabp3 208 25 monensin monensin NNP cord-294218-v4gjabp3 208 26 Speculations Speculations NNPS cord-294218-v4gjabp3 208 27 on on IN cord-294218-v4gjabp3 208 28 the the DT cord-294218-v4gjabp3 208 29 functions function NNS cord-294218-v4gjabp3 208 30 of of IN cord-294218-v4gjabp3 208 31 the the DT cord-294218-v4gjabp3 208 32 major major JJ cord-294218-v4gjabp3 208 33 heat heat NN cord-294218-v4gjabp3 208 34 - - HYPH cord-294218-v4gjabp3 208 35 shock shock NN cord-294218-v4gjabp3 208 36 and and CC cord-294218-v4gjabp3 208 37 glucoseregulated glucoseregulate VBN cord-294218-v4gjabp3 208 38 proteins protein NNS cord-294218-v4gjabp3 209 1 Coronaviral Coronaviral NNP cord-294218-v4gjabp3 209 2 enteritis enteritis NN cord-294218-v4gjabp3 209 3 of of IN cord-294218-v4gjabp3 209 4 turkeys turkey NNS cord-294218-v4gjabp3 209 5 RNA RNA NNP cord-294218-v4gjabp3 209 6 - - HYPH cord-294218-v4gjabp3 209 7 binding bind VBG cord-294218-v4gjabp3 209 8 proteins protein NNS cord-294218-v4gjabp3 209 9 of of IN cord-294218-v4gjabp3 209 10 coronavirus coronavirus NN cord-294218-v4gjabp3 209 11 MHV mhv NN cord-294218-v4gjabp3 209 12 : : : cord-294218-v4gjabp3 209 13 detection detection NN cord-294218-v4gjabp3 209 14 of of IN cord-294218-v4gjabp3 209 15 monomeric monomeric JJ cord-294218-v4gjabp3 209 16 and and CC cord-294218-v4gjabp3 209 17 multimeric multimeric JJ cord-294218-v4gjabp3 209 18 N n CD cord-294218-v4gjabp3 209 19 protein protein NN cord-294218-v4gjabp3 209 20 with with IN cord-294218-v4gjabp3 209 21 an an DT cord-294218-v4gjabp3 209 22 RNA RNA NNP cord-294218-v4gjabp3 209 23 overlay overlay NN cord-294218-v4gjabp3 209 24 - - HYPH cord-294218-v4gjabp3 209 25 protein protein NN cord-294218-v4gjabp3 209 26 blot blot NN cord-294218-v4gjabp3 209 27 assay assay NN cord-294218-v4gjabp3 209 28 Viral viral JJ cord-294218-v4gjabp3 209 29 protein protein NN cord-294218-v4gjabp3 209 30 synthesis synthesis NN cord-294218-v4gjabp3 209 31 in in IN cord-294218-v4gjabp3 209 32 mouse mouse NNP cord-294218-v4gjabp3 209 33 hepatitis hepatitis NNP cord-294218-v4gjabp3 209 34 virus virus NN cord-294218-v4gjabp3 209 35 strain strain VBP cord-294218-v4gjabp3 209 36 A59-infected a59-infecte VBN cord-294218-v4gjabp3 209 37 cells cell NNS cord-294218-v4gjabp3 209 38 : : : cord-294218-v4gjabp3 209 39 effect effect NN cord-294218-v4gjabp3 209 40 of of IN cord-294218-v4gjabp3 209 41 tunicamycin tunicamycin NNP cord-294218-v4gjabp3 209 42 Translation Translation NNP cord-294218-v4gjabp3 209 43 of of IN cord-294218-v4gjabp3 209 44 three three CD cord-294218-v4gjabp3 209 45 mouse mouse NN cord-294218-v4gjabp3 209 46 hepatitis hepatitis NN cord-294218-v4gjabp3 209 47 virus virus NN cord-294218-v4gjabp3 209 48 strain strain VBP cord-294218-v4gjabp3 209 49 A59 A59 NNP cord-294218-v4gjabp3 209 50 subgenomic subgenomic JJ cord-294218-v4gjabp3 209 51 RNAs rna NNS cord-294218-v4gjabp3 209 52 in in IN cord-294218-v4gjabp3 209 53 Xenopus Xenopus NNP cord-294218-v4gjabp3 209 54 laevis laevi NNS cord-294218-v4gjabp3 209 55 oocytes oocyte NNS cord-294218-v4gjabp3 210 1 Predicted predict VBN cord-294218-v4gjabp3 210 2 membrane membrane NN cord-294218-v4gjabp3 210 3 topology topology NN cord-294218-v4gjabp3 210 4 of of IN cord-294218-v4gjabp3 210 5 the the DT cord-294218-v4gjabp3 210 6 coronavirus coronavirus NN cord-294218-v4gjabp3 210 7 protein protein NN cord-294218-v4gjabp3 210 8 El El NNP cord-294218-v4gjabp3 210 9 Intracellular Intracellular NNP cord-294218-v4gjabp3 210 10 processing processing NN cord-294218-v4gjabp3 210 11 of of IN cord-294218-v4gjabp3 210 12 measles measles NNP cord-294218-v4gjabp3 210 13 virus virus NN cord-294218-v4gjabp3 210 14 fusion fusion NN cord-294218-v4gjabp3 210 15 protein protein NN cord-294218-v4gjabp3 210 16 Nucleotide nucleotide JJ cord-294218-v4gjabp3 210 17 sequence sequence NN cord-294218-v4gjabp3 210 18 of of IN cord-294218-v4gjabp3 210 19 the the DT cord-294218-v4gjabp3 210 20 gene gene NN cord-294218-v4gjabp3 210 21 encoding encode VBG cord-294218-v4gjabp3 210 22 the the DT cord-294218-v4gjabp3 210 23 surface surface NN cord-294218-v4gjabp3 210 24 projection projection NN cord-294218-v4gjabp3 210 25 glycoprotein glycoprotein NN cord-294218-v4gjabp3 210 26 of of IN cord-294218-v4gjabp3 210 27 coronavirus coronavirus NN cord-294218-v4gjabp3 210 28 MHV MHV NNP cord-294218-v4gjabp3 210 29 - - HYPH cord-294218-v4gjabp3 210 30 JHM JHM NNP cord-294218-v4gjabp3 210 31 Ter Ter NNP cord-294218-v4gjabp3 210 32 Meulen Meulen NNP cord-294218-v4gjabp3 210 33 V V NNP cord-294218-v4gjabp3 210 34 ( ( -LRB- cord-294218-v4gjabp3 210 35 t981 t981 NNP cord-294218-v4gjabp3 210 36 ) ) -RRB- cord-294218-v4gjabp3 210 37 Coronavirus Coronavirus NNP cord-294218-v4gjabp3 210 38 JHM JHM NNP cord-294218-v4gjabp3 210 39 intracellular intracellular JJ cord-294218-v4gjabp3 210 40 protein protein NN cord-294218-v4gjabp3 210 41 synthesis synthesis NN cord-294218-v4gjabp3 210 42 Coronavirus Coronavirus NNP cord-294218-v4gjabp3 210 43 JHM JHM NNP cord-294218-v4gjabp3 210 44 : : : cord-294218-v4gjabp3 211 1 coding code VBG cord-294218-v4gjabp3 211 2 assignments assignment NNS cord-294218-v4gjabp3 211 3 of of IN cord-294218-v4gjabp3 211 4 subgenomic subgenomic NNP cord-294218-v4gjabp3 211 5 mRNAs mRNAs . cord-294218-v4gjabp3 212 1 Isolation isolation NN cord-294218-v4gjabp3 212 2 and and CC cord-294218-v4gjabp3 212 3 identification identification NN cord-294218-v4gjabp3 212 4 of of IN cord-294218-v4gjabp3 212 5 virus virus NN cord-294218-v4gjabp3 212 6 - - HYPH cord-294218-v4gjabp3 212 7 specific specific JJ cord-294218-v4gjabp3 212 8 mRNAs mRNAs NNPS cord-294218-v4gjabp3 212 9 in in IN cord-294218-v4gjabp3 212 10 cells cell NNS cord-294218-v4gjabp3 212 11 infected infect VBN cord-294218-v4gjabp3 212 12 with with IN cord-294218-v4gjabp3 212 13 mouse mouse NN cord-294218-v4gjabp3 212 14 hepatitis hepatitis NN cord-294218-v4gjabp3 212 15 virus virus NN cord-294218-v4gjabp3 212 16 ( ( -LRB- cord-294218-v4gjabp3 212 17 MHV MHV NNP cord-294218-v4gjabp3 212 18 - - HYPH cord-294218-v4gjabp3 212 19 A59 A59 NNP cord-294218-v4gjabp3 212 20 ) ) -RRB- cord-294218-v4gjabp3 213 1 Coronavirus Coronavirus NNP cord-294218-v4gjabp3 213 2 multiplication multiplication NN cord-294218-v4gjabp3 213 3 strategy strategy NN cord-294218-v4gjabp3 213 4 . . . cord-294218-v4gjabp3 214 1 I. I. NNP cord-294218-v4gjabp3 214 2 Identification identification NN cord-294218-v4gjabp3 214 3 and and CC cord-294218-v4gjabp3 214 4 characterization characterization NN cord-294218-v4gjabp3 214 5 of of IN cord-294218-v4gjabp3 214 6 virus virus NN cord-294218-v4gjabp3 214 7 - - HYPH cord-294218-v4gjabp3 214 8 specific specific JJ cord-294218-v4gjabp3 214 9 RNA RNA NNP cord-294218-v4gjabp3 214 10 Coronavirus Coronavirus NNP cord-294218-v4gjabp3 214 11 proteins protein NNS cord-294218-v4gjabp3 214 12 : : : cord-294218-v4gjabp3 214 13 biogenesis biogenesis NN cord-294218-v4gjabp3 214 14 of of IN cord-294218-v4gjabp3 214 15 avian avian JJ cord-294218-v4gjabp3 214 16 infectious infectious JJ cord-294218-v4gjabp3 214 17 bronchitis bronchitis NN cord-294218-v4gjabp3 214 18 virus virus NN cord-294218-v4gjabp3 214 19 virion virion NN cord-294218-v4gjabp3 214 20 proteins protein VBZ cord-294218-v4gjabp3 214 21 Coronavirus Coronavirus NNP cord-294218-v4gjabp3 214 22 proteins protein NNS cord-294218-v4gjabp3 214 23 : : : cord-294218-v4gjabp3 215 1 structure structure NN cord-294218-v4gjabp3 215 2 and and CC cord-294218-v4gjabp3 215 3 function function NN cord-294218-v4gjabp3 215 4 of of IN cord-294218-v4gjabp3 215 5 the the DT cord-294218-v4gjabp3 215 6 oligosaccharides oligosaccharide NNS cord-294218-v4gjabp3 215 7 of of IN cord-294218-v4gjabp3 215 8 the the DT cord-294218-v4gjabp3 215 9 avian avian JJ cord-294218-v4gjabp3 215 10 bronchitis bronchitis NN cord-294218-v4gjabp3 215 11 virus virus NN cord-294218-v4gjabp3 215 12 glycoproteins glycoprotein VBZ cord-294218-v4gjabp3 215 13 Characterization characterization NN cord-294218-v4gjabp3 215 14 of of IN cord-294218-v4gjabp3 215 15 a a DT cord-294218-v4gjabp3 215 16 coronavirus coronavirus NN cord-294218-v4gjabp3 215 17 . . . cord-294218-v4gjabp3 216 1 II II NNP cord-294218-v4gjabp3 216 2 . . . cord-294218-v4gjabp3 217 1 Glycoproteins glycoprotein NNS cord-294218-v4gjabp3 217 2 of of IN cord-294218-v4gjabp3 217 3 the the DT cord-294218-v4gjabp3 217 4 viral viral JJ cord-294218-v4gjabp3 217 5 envelope envelope NN cord-294218-v4gjabp3 217 6 : : : cord-294218-v4gjabp3 217 7 tryptic tryptic NNP cord-294218-v4gjabp3 217 8 peptide peptide NN cord-294218-v4gjabp3 217 9 analysis analysis NN cord-294218-v4gjabp3 217 10 Isolation isolation NN cord-294218-v4gjabp3 217 11 of of IN cord-294218-v4gjabp3 217 12 coronavirus coronavirus NN cord-294218-v4gjabp3 217 13 envelope envelope NN cord-294218-v4gjabp3 217 14 glycoproteins glycoprotein NNS cord-294218-v4gjabp3 217 15 and and CC cord-294218-v4gjabp3 217 16 interaction interaction NN cord-294218-v4gjabp3 217 17 with with IN cord-294218-v4gjabp3 217 18 the the DT cord-294218-v4gjabp3 217 19 viral viral JJ cord-294218-v4gjabp3 217 20 nucleocapsid nucleocapsid NN cord-294218-v4gjabp3 218 1 The the DT cord-294218-v4gjabp3 218 2 molecular molecular JJ cord-294218-v4gjabp3 218 3 biotogy biotogy NN cord-294218-v4gjabp3 218 4 of of IN cord-294218-v4gjabp3 218 5 coronaviruses coronaviruse NNS cord-294218-v4gjabp3 219 1 Proteolytic proteolytic JJ cord-294218-v4gjabp3 219 2 cleavage cleavage NN cord-294218-v4gjabp3 219 3 of of IN cord-294218-v4gjabp3 219 4 the the DT cord-294218-v4gjabp3 219 5 E2 E2 NNP cord-294218-v4gjabp3 219 6 glycoprotein glycoprotein NN cord-294218-v4gjabp3 219 7 of of IN cord-294218-v4gjabp3 219 8 murine murine JJ cord-294218-v4gjabp3 219 9 coronavirus coronavirus NN cord-294218-v4gjabp3 219 10 : : : cord-294218-v4gjabp3 219 11 activation activation NN cord-294218-v4gjabp3 219 12 of of IN cord-294218-v4gjabp3 219 13 cell cell NN cord-294218-v4gjabp3 219 14 - - HYPH cord-294218-v4gjabp3 219 15 fusing fuse VBG cord-294218-v4gjabp3 219 16 activity activity NN cord-294218-v4gjabp3 219 17 of of IN cord-294218-v4gjabp3 219 18 virions virion NNS cord-294218-v4gjabp3 219 19 by by IN cord-294218-v4gjabp3 219 20 trypsin trypsin NN cord-294218-v4gjabp3 219 21 and and CC cord-294218-v4gjabp3 219 22 separation separation NN cord-294218-v4gjabp3 219 23 of of IN cord-294218-v4gjabp3 220 1 two two CD cord-294218-v4gjabp3 220 2 different different JJ cord-294218-v4gjabp3 220 3 90 90 CD cord-294218-v4gjabp3 220 4 K k NN cord-294218-v4gjabp3 220 5 cleavage cleavage NN cord-294218-v4gjabp3 220 6 fragments fragment NNS cord-294218-v4gjabp3 220 7 Infection infection NN cord-294218-v4gjabp3 220 8 of of IN cord-294218-v4gjabp3 220 9 AtT20 AtT20 NNP cord-294218-v4gjabp3 220 10 murine murine JJ cord-294218-v4gjabp3 220 11 pituitary pituitary JJ cord-294218-v4gjabp3 220 12 tumour tumour NN cord-294218-v4gjabp3 220 13 cells cell NNS cord-294218-v4gjabp3 220 14 by by IN cord-294218-v4gjabp3 220 15 mouse mouse NN cord-294218-v4gjabp3 220 16 hepatitis hepatitis NNP cord-294218-v4gjabp3 220 17 virus virus NN cord-294218-v4gjabp3 220 18 strain strain VBP cord-294218-v4gjabp3 220 19 A a DT cord-294218-v4gjabp3 220 20 59 59 CD cord-294218-v4gjabp3 220 21 : : : cord-294218-v4gjabp3 220 22 virus virus NN cord-294218-v4gjabp3 220 23 budding budding NN cord-294218-v4gjabp3 220 24 is be VBZ cord-294218-v4gjabp3 220 25 restricted restrict VBN cord-294218-v4gjabp3 220 26 to to IN cord-294218-v4gjabp3 220 27 the the DT cord-294218-v4gjabp3 220 28 Golgi Golgi NNP cord-294218-v4gjabp3 220 29 region region NN cord-294218-v4gjabp3 221 1 The the DT cord-294218-v4gjabp3 221 2 authors author NNS cord-294218-v4gjabp3 221 3 would would MD cord-294218-v4gjabp3 221 4 like like VB cord-294218-v4gjabp3 221 5 to to TO cord-294218-v4gjabp3 221 6 acknowledge acknowledge VB cord-294218-v4gjabp3 221 7 the the DT cord-294218-v4gjabp3 221 8 technical technical JJ cord-294218-v4gjabp3 221 9 assistance assistance NN cord-294218-v4gjabp3 221 10 of of IN cord-294218-v4gjabp3 221 11 H. H. NNP cord-294218-v4gjabp3 221 12 Strykowski Strykowski NNP cord-294218-v4gjabp3 221 13 for for IN cord-294218-v4gjabp3 221 14 preparing prepare VBG cord-294218-v4gjabp3 221 15 the the DT cord-294218-v4gjabp3 221 16 specimens specimen NNS cord-294218-v4gjabp3 221 17 for for IN cord-294218-v4gjabp3 221 18 electron electron NN cord-294218-v4gjabp3 221 19 microscopy microscopy NN cord-294218-v4gjabp3 221 20 . . . cord-294218-v4gjabp3 221 21 _SP cord-294218-v4gjabp3 222 1 Authors author NNS cord-294218-v4gjabp3 222 2 ' ' POS cord-294218-v4gjabp3 222 3 address address NN cord-294218-v4gjabp3 222 4 : : : cord-294218-v4gjabp3 222 5 P. P. NNP cord-294218-v4gjabp3 222 6 Tijssen Tijssen NNP cord-294218-v4gjabp3 222 7 , , , cord-294218-v4gjabp3 222 8 Centre Centre NNP cord-294218-v4gjabp3 222 9 de de FW cord-294218-v4gjabp3 222 10 Recherche recherche FW cord-294218-v4gjabp3 222 11 en en IN cord-294218-v4gjabp3 222 12 M M NNP cord-294218-v4gjabp3 222 13 ~ ~ NFP cord-294218-v4gjabp3 222 14 decine decine NNP cord-294218-v4gjabp3 222 15 Compar6e Compar6e NNP cord-294218-v4gjabp3 222 16 Institut Institut NNP cord-294218-v4gjabp3 222 17 Armand Armand NNP cord-294218-v4gjabp3 222 18 - - HYPH cord-294218-v4gjabp3 222 19 Frappier Frappier NNP cord-294218-v4gjabp3 222 20 , , , cord-294218-v4gjabp3 222 21 531 531 CD cord-294218-v4gjabp3 222 22 , , , cord-294218-v4gjabp3 222 23 boulevard boulevard NNP cord-294218-v4gjabp3 222 24 de de FW cord-294218-v4gjabp3 222 25 Prairies Prairies NNP cord-294218-v4gjabp3 222 26 Laval Laval NNP cord-294218-v4gjabp3 222 27 - - HYPH cord-294218-v4gjabp3 222 28 des des NNP cord-294218-v4gjabp3 222 29 - - HYPH cord-294218-v4gjabp3 222 30 Rapides Rapides NNP cord-294218-v4gjabp3 222 31 , , , cord-294218-v4gjabp3 222 32 Quebec Quebec NNP cord-294218-v4gjabp3 222 33 H7V h7v CD cord-294218-v4gjabp3 222 34 1B7 1b7 CD cord-294218-v4gjabp3 222 35 , , , cord-294218-v4gjabp3 222 36 Canada Canada NNP cord-294218-v4gjabp3 222 37 . . . cord-294218-v4gjabp3 223 1 Received receive VBN cord-294218-v4gjabp3 223 2 February February NNP cord-294218-v4gjabp3 223 3 2 2 CD cord-294218-v4gjabp3 223 4 , , , cord-294218-v4gjabp3 223 5 1989 1989 CD cord-294218-v4gjabp3 223 6 _SP