id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-032801-b2ncmkjg	Song, Jie	Transcriptome analysis following enterovirus 71 and coxsackievirus A16 infection in respiratory epithelial cells	2020-09-29		.txt	text/plain	4930	238	48	It was discovered that enriched GO terms (such as histone acetylation and positive regulation of phosphorylation) and pathways (such as glycosylphosphatidylinositol (GPI)-anchor biosynthesis and DNA replication) might be closely associated with the pathogenic mechanism of these two viruses, and key genes (such as TBCK and GPC) might be involved in the progression of HFMD. In the current study, we aimed to discover significant differentially expressed genes in EV-A71-and CV-A16-infected respiratory epithelial cells through transcriptome sequencing. For example, transcriptome analysis revealed differentially expressed genes, including SCARB2, miR-3605-5p, and enriched ECM-receptor interaction and circadian rhythm pathways involved in the pathogenesis of HFMD in CV-A16-infected HEK 293T cells [9] . These 111 common differentially expressed genes were used to perform hierarchical cluster analysis, and the heatmap result showed that these genes were mainly clustered into two categories-either significantly upregulated or significantly downregulated, suggesting that EV-A71 and CV-A16 infections result in largely similar transcriptome-level changes.	./cache/cord-032801-b2ncmkjg.txt	./txt/cord-032801-b2ncmkjg.txt