id	sid	tid	token	lemma	pos
cord-316996-8yimrpaz	1	1	key	key	NN
cord-316996-8yimrpaz	1	2	:	:	:
cord-316996-8yimrpaz	2	1	cord-316996	cord-316996	NNP
cord-316996-8yimrpaz	2	2	-	-	HYPH
cord-316996-8yimrpaz	2	3	8yimrpaz	8yimrpaz	CD
cord-316996-8yimrpaz	2	4	authors	author	NNS
cord-316996-8yimrpaz	2	5	:	:	:
cord-316996-8yimrpaz	2	6	Nicholls	Nicholls	NNP
cord-316996-8yimrpaz	2	7	,	,	,
cord-316996-8yimrpaz	2	8	John	John	NNP
cord-316996-8yimrpaz	2	9	M.	M.	NNP
cord-316996-8yimrpaz	2	10	;	;	:
cord-316996-8yimrpaz	2	11	Moss	Moss	NNP
cord-316996-8yimrpaz	2	12	,	,	,
cord-316996-8yimrpaz	2	13	Ronald	Ronald	NNP
cord-316996-8yimrpaz	2	14	B.	B.	NNP
cord-316996-8yimrpaz	2	15	;	;	:
cord-316996-8yimrpaz	2	16	Haslam	Haslam	NNP
cord-316996-8yimrpaz	2	17	,	,	,
cord-316996-8yimrpaz	2	18	Stuart	Stuart	NNP
cord-316996-8yimrpaz	2	19	M.	M.	NNP
cord-316996-8yimrpaz	2	20	title	title	NN
cord-316996-8yimrpaz	2	21	:	:	:
cord-316996-8yimrpaz	2	22	The	the	DT
cord-316996-8yimrpaz	2	23	use	use	NN
cord-316996-8yimrpaz	2	24	of	of	IN
cord-316996-8yimrpaz	2	25	sialidase	sialidase	NN
cord-316996-8yimrpaz	2	26	therapy	therapy	NN
cord-316996-8yimrpaz	2	27	for	for	IN
cord-316996-8yimrpaz	2	28	respiratory	respiratory	JJ
cord-316996-8yimrpaz	2	29	viral	viral	JJ
cord-316996-8yimrpaz	2	30	infections	infection	NNS
cord-316996-8yimrpaz	2	31	date	date	NN
cord-316996-8yimrpaz	2	32	:	:	:
cord-316996-8yimrpaz	2	33	2013	2013	CD
cord-316996-8yimrpaz	2	34	-	-	HYPH
cord-316996-8yimrpaz	2	35	04	04	CD
cord-316996-8yimrpaz	2	36	-	-	SYM
cord-316996-8yimrpaz	2	37	17	17	CD
cord-316996-8yimrpaz	2	38	journal	journal	NN
cord-316996-8yimrpaz	2	39	:	:	:
cord-316996-8yimrpaz	3	1	Antiviral	antiviral	JJ
cord-316996-8yimrpaz	3	2	Res	res	NN
cord-316996-8yimrpaz	3	3	DOI	doi	NN
cord-316996-8yimrpaz	3	4	:	:	:
cord-316996-8yimrpaz	3	5	10.1016	10.1016	CD
cord-316996-8yimrpaz	3	6	/	/	SYM
cord-316996-8yimrpaz	3	7	j.antiviral.2013.04.012	j.antiviral.2013.04.012	NNP
cord-316996-8yimrpaz	3	8	sha	sha	NN
cord-316996-8yimrpaz	3	9	:	:	:
cord-316996-8yimrpaz	3	10	4616ee474de0d566dfd9f230383dccc48d38af9b	4616ee474de0d566dfd9f230383dccc48d38af9b	CD
cord-316996-8yimrpaz	3	11	doc_id	doc_id	CD
cord-316996-8yimrpaz	3	12	:	:	:
cord-316996-8yimrpaz	3	13	316996	316996	CD
cord-316996-8yimrpaz	3	14	cord_uid	cord_uid	NNS
cord-316996-8yimrpaz	3	15	:	:	:
cord-316996-8yimrpaz	4	1	8yimrpaz	8yimrpaz	CD
cord-316996-8yimrpaz	5	1	DAS181	DAS181	NNP
cord-316996-8yimrpaz	5	2	is	be	VBZ
cord-316996-8yimrpaz	5	3	an	an	DT
cord-316996-8yimrpaz	5	4	inhaled	inhale	VBN
cord-316996-8yimrpaz	5	5	bacterial	bacterial	JJ
cord-316996-8yimrpaz	5	6	sialidase	sialidase	NN
cord-316996-8yimrpaz	5	7	which	which	WDT
cord-316996-8yimrpaz	5	8	functions	function	NNS
cord-316996-8yimrpaz	5	9	by	by	IN
cord-316996-8yimrpaz	5	10	removing	remove	VBG
cord-316996-8yimrpaz	5	11	sialic	sialic	NN
cord-316996-8yimrpaz	5	12	acid	acid	NN
cord-316996-8yimrpaz	5	13	(	(	-LRB-
cord-316996-8yimrpaz	5	14	Sia	Sia	NNP
cord-316996-8yimrpaz	5	15	)	)	-RRB-
cord-316996-8yimrpaz	5	16	from	from	IN
cord-316996-8yimrpaz	5	17	the	the	DT
cord-316996-8yimrpaz	5	18	surface	surface	NN
cord-316996-8yimrpaz	5	19	of	of	IN
cord-316996-8yimrpaz	5	20	epithelial	epithelial	JJ
cord-316996-8yimrpaz	5	21	cells	cell	NNS
cord-316996-8yimrpaz	5	22	,	,	,
cord-316996-8yimrpaz	5	23	preventing	prevent	VBG
cord-316996-8yimrpaz	5	24	attachment	attachment	NN
cord-316996-8yimrpaz	5	25	and	and	CC
cord-316996-8yimrpaz	5	26	subsequent	subsequent	JJ
cord-316996-8yimrpaz	5	27	infection	infection	NN
cord-316996-8yimrpaz	5	28	by	by	IN
cord-316996-8yimrpaz	5	29	respiratory	respiratory	JJ
cord-316996-8yimrpaz	5	30	viruses	virus	NNS
cord-316996-8yimrpaz	5	31	that	that	WDT
cord-316996-8yimrpaz	5	32	utilize	utilize	VBP
cord-316996-8yimrpaz	5	33	Sia	Sia	NNP
cord-316996-8yimrpaz	5	34	as	as	IN
cord-316996-8yimrpaz	5	35	a	a	DT
cord-316996-8yimrpaz	5	36	receptor	receptor	NN
cord-316996-8yimrpaz	5	37	.	.	.
cord-316996-8yimrpaz	6	1	DAS181	DAS181	NNP
cord-316996-8yimrpaz	6	2	is	be	VBZ
cord-316996-8yimrpaz	6	3	typical	typical	JJ
cord-316996-8yimrpaz	6	4	of	of	IN
cord-316996-8yimrpaz	6	5	bacterial	bacterial	JJ
cord-316996-8yimrpaz	6	6	sialidases	sialidase	NNS
cord-316996-8yimrpaz	6	7	in	in	IN
cord-316996-8yimrpaz	6	8	cleaving	cleave	VBG
cord-316996-8yimrpaz	6	9	Sia	Sia	NNP
cord-316996-8yimrpaz	6	10	α2	α2	NNP
cord-316996-8yimrpaz	6	11	-	-	HYPH
cord-316996-8yimrpaz	6	12	3	3	NNP
cord-316996-8yimrpaz	6	13	and	and	CC
cord-316996-8yimrpaz	6	14	Sia	Sia	NNP
cord-316996-8yimrpaz	6	15	α2	α2	NNP
cord-316996-8yimrpaz	6	16	-	-	HYPH
cord-316996-8yimrpaz	6	17	6	6	CD
cord-316996-8yimrpaz	6	18	linkages	linkage	NNS
cord-316996-8yimrpaz	6	19	,	,	,
cord-316996-8yimrpaz	6	20	and	and	CC
cord-316996-8yimrpaz	6	21	it	-PRON-	PRP
cord-316996-8yimrpaz	6	22	also	also	RB
cord-316996-8yimrpaz	6	23	has	have	VBZ
cord-316996-8yimrpaz	6	24	a	a	DT
cord-316996-8yimrpaz	6	25	demonstrated	demonstrate	VBN
cord-316996-8yimrpaz	6	26	effect	effect	NN
cord-316996-8yimrpaz	6	27	against	against	IN
cord-316996-8yimrpaz	6	28	acetylated	acetylated	JJ
cord-316996-8yimrpaz	6	29	and	and	CC
cord-316996-8yimrpaz	6	30	hydroxylated	hydroxylated	JJ
cord-316996-8yimrpaz	6	31	forms	form	NNS
cord-316996-8yimrpaz	6	32	of	of	IN
cord-316996-8yimrpaz	6	33	Sia	Sia	NNP
cord-316996-8yimrpaz	6	34	.	.	.
cord-316996-8yimrpaz	7	1	The	the	DT
cord-316996-8yimrpaz	7	2	potency	potency	NN
cord-316996-8yimrpaz	7	3	of	of	IN
cord-316996-8yimrpaz	7	4	the	the	DT
cord-316996-8yimrpaz	7	5	compound	compound	NN
cord-316996-8yimrpaz	7	6	has	have	VBZ
cord-316996-8yimrpaz	7	7	been	be	VBN
cord-316996-8yimrpaz	7	8	enhanced	enhance	VBN
cord-316996-8yimrpaz	7	9	by	by	IN
cord-316996-8yimrpaz	7	10	coupling	couple	VBG
cord-316996-8yimrpaz	7	11	the	the	DT
cord-316996-8yimrpaz	7	12	active	active	JJ
cord-316996-8yimrpaz	7	13	sialidase	sialidase	NN
cord-316996-8yimrpaz	7	14	with	with	IN
cord-316996-8yimrpaz	7	15	an	an	DT
cord-316996-8yimrpaz	7	16	amphiregulin	amphiregulin	NN
cord-316996-8yimrpaz	7	17	tag	tag	NN
cord-316996-8yimrpaz	7	18	,	,	,
cord-316996-8yimrpaz	7	19	allowing	allow	VBG
cord-316996-8yimrpaz	7	20	a	a	DT
cord-316996-8yimrpaz	7	21	longer	long	JJR
cord-316996-8yimrpaz	7	22	duration	duration	NN
cord-316996-8yimrpaz	7	23	of	of	IN
cord-316996-8yimrpaz	7	24	action	action	NN
cord-316996-8yimrpaz	7	25	and	and	CC
cord-316996-8yimrpaz	7	26	minimizing	minimize	VBG
cord-316996-8yimrpaz	7	27	spread	spread	VBN
cord-316996-8yimrpaz	7	28	to	to	IN
cord-316996-8yimrpaz	7	29	the	the	DT
cord-316996-8yimrpaz	7	30	systemic	systemic	JJ
cord-316996-8yimrpaz	7	31	circulation	circulation	NN
cord-316996-8yimrpaz	7	32	.	.	.
cord-316996-8yimrpaz	8	1	DAS181	DAS181	NNP
cord-316996-8yimrpaz	8	2	is	be	VBZ
cord-316996-8yimrpaz	8	3	now	now	RB
cord-316996-8yimrpaz	8	4	in	in	IN
cord-316996-8yimrpaz	8	5	Phase	Phase	NNP
cord-316996-8yimrpaz	8	6	II	II	NNP
cord-316996-8yimrpaz	8	7	development	development	NN
cord-316996-8yimrpaz	8	8	for	for	IN
cord-316996-8yimrpaz	8	9	the	the	DT
cord-316996-8yimrpaz	8	10	treatment	treatment	NN
cord-316996-8yimrpaz	8	11	of	of	IN
cord-316996-8yimrpaz	8	12	influenza	influenza	NN
cord-316996-8yimrpaz	8	13	,	,	,
cord-316996-8yimrpaz	8	14	and	and	CC
cord-316996-8yimrpaz	8	15	it	-PRON-	PRP
cord-316996-8yimrpaz	8	16	has	have	VBZ
cord-316996-8yimrpaz	8	17	also	also	RB
cord-316996-8yimrpaz	8	18	demonstrated	demonstrate	VBN
cord-316996-8yimrpaz	8	19	activity	activity	NN
cord-316996-8yimrpaz	8	20	in	in	IN
cord-316996-8yimrpaz	8	21	individual	individual	JJ
cord-316996-8yimrpaz	8	22	cases	case	NNS
cord-316996-8yimrpaz	8	23	of	of	IN
cord-316996-8yimrpaz	8	24	parainfluenza	parainfluenza	NN
cord-316996-8yimrpaz	8	25	in	in	IN
cord-316996-8yimrpaz	8	26	immunosuppressed	immunosuppressed	JJ
cord-316996-8yimrpaz	8	27	patients	patient	NNS
cord-316996-8yimrpaz	8	28	.	.	.
cord-316996-8yimrpaz	9	1	Continued	continued	JJ
cord-316996-8yimrpaz	9	2	evaluation	evaluation	NN
cord-316996-8yimrpaz	9	3	of	of	IN
cord-316996-8yimrpaz	9	4	the	the	DT
cord-316996-8yimrpaz	9	5	roles	role	NNS
cord-316996-8yimrpaz	9	6	and	and	CC
cord-316996-8yimrpaz	9	7	activities	activity	NNS
cord-316996-8yimrpaz	9	8	of	of	IN
cord-316996-8yimrpaz	9	9	bacterial	bacterial	JJ
cord-316996-8yimrpaz	9	10	sialidases	sialidase	NNS
cord-316996-8yimrpaz	9	11	is	be	VBZ
cord-316996-8yimrpaz	9	12	required	require	VBN
cord-316996-8yimrpaz	9	13	to	to	TO
cord-316996-8yimrpaz	9	14	expand	expand	VB
cord-316996-8yimrpaz	9	15	the	the	DT
cord-316996-8yimrpaz	9	16	range	range	NN
cord-316996-8yimrpaz	9	17	of	of	IN
cord-316996-8yimrpaz	9	18	successful	successful	JJ
cord-316996-8yimrpaz	9	19	antiviral	antiviral	JJ
cord-316996-8yimrpaz	9	20	therapies	therapy	NNS
cord-316996-8yimrpaz	9	21	targeting	target	VBG
cord-316996-8yimrpaz	9	22	Sia	Sia	NNP
cord-316996-8yimrpaz	9	23	or	or	CC
cord-316996-8yimrpaz	9	24	its	-PRON-	PRP$
cord-316996-8yimrpaz	9	25	derivatives	derivative	NNS
cord-316996-8yimrpaz	9	26	.	.	.
cord-316996-8yimrpaz	10	1	-an	-an	:
cord-316996-8yimrpaz	11	1	interaction	interaction	NN
cord-316996-8yimrpaz	11	2	involving	involve	VBG
cord-316996-8yimrpaz	11	3	viral	viral	JJ
cord-316996-8yimrpaz	11	4	polypeptides	polypeptide	NNS
cord-316996-8yimrpaz	11	5	or	or	CC
cord-316996-8yimrpaz	11	6	attachment	attachment	NN
cord-316996-8yimrpaz	11	7	proteins	protein	NNS
cord-316996-8yimrpaz	11	8	and	and	CC
cord-316996-8yimrpaz	11	9	cognate	cognate	JJ
cord-316996-8yimrpaz	11	10	cell	cell	NN
cord-316996-8yimrpaz	11	11	-	-	HYPH
cord-316996-8yimrpaz	11	12	surface	surface	NN
cord-316996-8yimrpaz	11	13	receptors	receptor	NNS
cord-316996-8yimrpaz	11	14	.	.	.
cord-316996-8yimrpaz	12	1	DAS181	DAS181	NNP
cord-316996-8yimrpaz	12	2	is	be	VBZ
cord-316996-8yimrpaz	12	3	the	the	DT
cord-316996-8yimrpaz	12	4	first	first	JJ
cord-316996-8yimrpaz	12	5	antiviral	antiviral	JJ
cord-316996-8yimrpaz	12	6	compound	compound	NN
cord-316996-8yimrpaz	12	7	in	in	IN
cord-316996-8yimrpaz	12	8	Phase	Phase	NNP
cord-316996-8yimrpaz	12	9	II	II	NNP
cord-316996-8yimrpaz	12	10	development	development	NN
cord-316996-8yimrpaz	12	11	that	that	WDT
cord-316996-8yimrpaz	12	12	functions	function	NNS
cord-316996-8yimrpaz	12	13	by	by	IN
cord-316996-8yimrpaz	12	14	blocking	block	VBG
cord-316996-8yimrpaz	12	15	this	this	DT
cord-316996-8yimrpaz	12	16	pathogen	pathogen	NN
cord-316996-8yimrpaz	12	17	-	-	HYPH
cord-316996-8yimrpaz	12	18	host	host	NN
cord-316996-8yimrpaz	12	19	interaction	interaction	NN
cord-316996-8yimrpaz	12	20	,	,	,
cord-316996-8yimrpaz	12	21	by	by	IN
cord-316996-8yimrpaz	12	22	destroying	destroy	VBG
cord-316996-8yimrpaz	12	23	the	the	DT
cord-316996-8yimrpaz	12	24	influenza	influenza	NN
cord-316996-8yimrpaz	12	25	host	host	NN
cord-316996-8yimrpaz	12	26	-	-	HYPH
cord-316996-8yimrpaz	12	27	cell	cell	NN
cord-316996-8yimrpaz	12	28	receptor	receptor	NN
cord-316996-8yimrpaz	12	29	,	,	,
cord-316996-8yimrpaz	12	30	sialic	sialic	JJ
cord-316996-8yimrpaz	12	31	acid	acid	NN
cord-316996-8yimrpaz	12	32	(	(	-LRB-
cord-316996-8yimrpaz	12	33	Sia	Sia	NNP
cord-316996-8yimrpaz	12	34	)	)	-RRB-
cord-316996-8yimrpaz	12	35	,	,	,
cord-316996-8yimrpaz	12	36	on	on	IN
cord-316996-8yimrpaz	12	37	the	the	DT
cord-316996-8yimrpaz	12	38	surface	surface	NN
cord-316996-8yimrpaz	12	39	of	of	IN
cord-316996-8yimrpaz	12	40	respiratory	respiratory	JJ
cord-316996-8yimrpaz	12	41	epithelial	epithelial	JJ
cord-316996-8yimrpaz	12	42	cells	cell	NNS
cord-316996-8yimrpaz	12	43	.	.	.
cord-316996-8yimrpaz	13	1	In	in	IN
cord-316996-8yimrpaz	13	2	this	this	DT
cord-316996-8yimrpaz	13	3	paper	paper	NN
cord-316996-8yimrpaz	13	4	,	,	,
cord-316996-8yimrpaz	13	5	we	-PRON-	PRP
cord-316996-8yimrpaz	13	6	provide	provide	VBP
cord-316996-8yimrpaz	13	7	background	background	NN
cord-316996-8yimrpaz	13	8	information	information	NN
cord-316996-8yimrpaz	13	9	on	on	IN
cord-316996-8yimrpaz	13	10	Sia	Sia	NNP
cord-316996-8yimrpaz	13	11	and	and	CC
cord-316996-8yimrpaz	13	12	sialidases	sialidase	NNS
cord-316996-8yimrpaz	13	13	;	;	:
cord-316996-8yimrpaz	13	14	discuss	discuss	VB
cord-316996-8yimrpaz	13	15	the	the	DT
cord-316996-8yimrpaz	13	16	potential	potential	JJ
cord-316996-8yimrpaz	13	17	role	role	NN
cord-316996-8yimrpaz	13	18	of	of	IN
cord-316996-8yimrpaz	13	19	bacterial	bacterial	JJ
cord-316996-8yimrpaz	13	20	sialidases	sialidase	NNS
cord-316996-8yimrpaz	13	21	as	as	IN
cord-316996-8yimrpaz	13	22	antiviral	antiviral	JJ
cord-316996-8yimrpaz	13	23	agents	agent	NNS
cord-316996-8yimrpaz	13	24	;	;	:
cord-316996-8yimrpaz	13	25	review	review	VB
cord-316996-8yimrpaz	13	26	the	the	DT
cord-316996-8yimrpaz	13	27	in	in	FW
cord-316996-8yimrpaz	13	28	vitro	vitro	FW
cord-316996-8yimrpaz	13	29	and	and	CC
cord-316996-8yimrpaz	13	30	Phase	Phase	NNP
cord-316996-8yimrpaz	13	31	II	ii	CD
cord-316996-8yimrpaz	13	32	evaluation	evaluation	NN
cord-316996-8yimrpaz	13	33	of	of	IN
cord-316996-8yimrpaz	13	34	DAS181	DAS181	NNP
cord-316996-8yimrpaz	13	35	for	for	IN
cord-316996-8yimrpaz	13	36	the	the	DT
cord-316996-8yimrpaz	13	37	treatment	treatment	NN
cord-316996-8yimrpaz	13	38	of	of	IN
cord-316996-8yimrpaz	13	39	influenza	influenza	NN
cord-316996-8yimrpaz	13	40	;	;	:
cord-316996-8yimrpaz	13	41	and	and	CC
cord-316996-8yimrpaz	13	42	note	note	VB
cord-316996-8yimrpaz	13	43	evidence	evidence	NN
cord-316996-8yimrpaz	13	44	that	that	IN
cord-316996-8yimrpaz	13	45	the	the	DT
cord-316996-8yimrpaz	13	46	drug	drug	NN
cord-316996-8yimrpaz	13	47	would	would	MD
cord-316996-8yimrpaz	13	48	also	also	RB
cord-316996-8yimrpaz	13	49	be	be	VB
cord-316996-8yimrpaz	13	50	useful	useful	JJ
cord-316996-8yimrpaz	13	51	against	against	IN
cord-316996-8yimrpaz	13	52	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	13	53	virus	virus	NN
cord-316996-8yimrpaz	13	54	infections	infection	NNS
cord-316996-8yimrpaz	13	55	.	.	.
cord-316996-8yimrpaz	14	1	Current	current	JJ
cord-316996-8yimrpaz	14	2	antiviral	antiviral	JJ
cord-316996-8yimrpaz	14	3	strategies	strategy	NNS
cord-316996-8yimrpaz	14	4	focus	focus	VBP
cord-316996-8yimrpaz	14	5	on	on	IN
cord-316996-8yimrpaz	14	6	prevention	prevention	NN
cord-316996-8yimrpaz	14	7	of	of	IN
cord-316996-8yimrpaz	14	8	viral	viral	JJ
cord-316996-8yimrpaz	14	9	replication	replication	NN
cord-316996-8yimrpaz	14	10	within	within	IN
cord-316996-8yimrpaz	14	11	the	the	DT
cord-316996-8yimrpaz	14	12	cell	cell	NN
cord-316996-8yimrpaz	14	13	or	or	CC
cord-316996-8yimrpaz	14	14	inhibition	inhibition	NN
cord-316996-8yimrpaz	14	15	of	of	IN
cord-316996-8yimrpaz	14	16	release	release	NN
cord-316996-8yimrpaz	14	17	of	of	IN
cord-316996-8yimrpaz	14	18	newly	newly	RB
cord-316996-8yimrpaz	14	19	formed	form	VBN
cord-316996-8yimrpaz	14	20	virions	virion	NNS
cord-316996-8yimrpaz	14	21	.	.	.
cord-316996-8yimrpaz	15	1	Neuraminidase	Neuraminidase	NNP
cord-316996-8yimrpaz	15	2	(	(	-LRB-
cord-316996-8yimrpaz	15	3	NA	NA	NNP
cord-316996-8yimrpaz	15	4	)	)	-RRB-
cord-316996-8yimrpaz	15	5	inhibitors	inhibitor	NNS
cord-316996-8yimrpaz	15	6	primarily	primarily	RB
cord-316996-8yimrpaz	15	7	act	act	VBP
cord-316996-8yimrpaz	15	8	at	at	IN
cord-316996-8yimrpaz	15	9	this	this	DT
cord-316996-8yimrpaz	15	10	step	step	NN
cord-316996-8yimrpaz	15	11	,	,	,
cord-316996-8yimrpaz	15	12	but	but	CC
cord-316996-8yimrpaz	15	13	they	-PRON-	PRP
cord-316996-8yimrpaz	15	14	play	play	VBP
cord-316996-8yimrpaz	15	15	a	a	DT
cord-316996-8yimrpaz	15	16	minor	minor	JJ
cord-316996-8yimrpaz	15	17	role	role	NN
cord-316996-8yimrpaz	15	18	in	in	IN
cord-316996-8yimrpaz	15	19	modulating	modulate	VBG
cord-316996-8yimrpaz	15	20	viral	viral	JJ
cord-316996-8yimrpaz	15	21	entry	entry	NN
cord-316996-8yimrpaz	15	22	(	(	-LRB-
cord-316996-8yimrpaz	15	23	Matrosovich	Matrosovich	NNP
cord-316996-8yimrpaz	15	24	et	et	NNP
cord-316996-8yimrpaz	15	25	al	al	NNP
cord-316996-8yimrpaz	15	26	.	.	NNP
cord-316996-8yimrpaz	15	27	,	,	,
cord-316996-8yimrpaz	15	28	2004	2004	CD
cord-316996-8yimrpaz	15	29	)	)	-RRB-
cord-316996-8yimrpaz	15	30	.	.	.
cord-316996-8yimrpaz	16	1	The	the	DT
cord-316996-8yimrpaz	16	2	first	first	JJ
cord-316996-8yimrpaz	16	3	step	step	NN
cord-316996-8yimrpaz	16	4	of	of	IN
cord-316996-8yimrpaz	16	5	viral	viral	JJ
cord-316996-8yimrpaz	16	6	binding	binding	NN
cord-316996-8yimrpaz	16	7	often	often	RB
cord-316996-8yimrpaz	16	8	involves	involve	VBZ
cord-316996-8yimrpaz	16	9	close	close	JJ
cord-316996-8yimrpaz	16	10	contact	contact	NN
cord-316996-8yimrpaz	16	11	between	between	IN
cord-316996-8yimrpaz	16	12	the	the	DT
cord-316996-8yimrpaz	16	13	viral	viral	JJ
cord-316996-8yimrpaz	16	14	attachment	attachment	NN
cord-316996-8yimrpaz	16	15	protein	protein	NN
cord-316996-8yimrpaz	16	16	and	and	CC
cord-316996-8yimrpaz	16	17	host	host	NN
cord-316996-8yimrpaz	16	18	receptor	receptor	NN
cord-316996-8yimrpaz	16	19	.	.	.
cord-316996-8yimrpaz	17	1	Before	before	IN
cord-316996-8yimrpaz	17	2	the	the	DT
cord-316996-8yimrpaz	17	3	development	development	NN
cord-316996-8yimrpaz	17	4	of	of	IN
cord-316996-8yimrpaz	17	5	DAS181	DAS181	NNP
cord-316996-8yimrpaz	17	6	,	,	,
cord-316996-8yimrpaz	17	7	studies	study	NNS
cord-316996-8yimrpaz	17	8	in	in	IN
cord-316996-8yimrpaz	17	9	the	the	DT
cord-316996-8yimrpaz	17	10	1980s	1980	NNS
cord-316996-8yimrpaz	17	11	demonstrated	demonstrate	VBD
cord-316996-8yimrpaz	17	12	that	that	IN
cord-316996-8yimrpaz	17	13	natural	natural	JJ
cord-316996-8yimrpaz	17	14	compounds	compound	NNS
cord-316996-8yimrpaz	17	15	present	present	JJ
cord-316996-8yimrpaz	17	16	in	in	IN
cord-316996-8yimrpaz	17	17	serum	serum	NN
cord-316996-8yimrpaz	17	18	,	,	,
cord-316996-8yimrpaz	17	19	in	in	IN
cord-316996-8yimrpaz	17	20	particular	particular	JJ
cord-316996-8yimrpaz	17	21	alpha	alpha	NN
cord-316996-8yimrpaz	17	22	2-macroglobulin	2-macroglobulin	CD
cord-316996-8yimrpaz	17	23	,	,	,
cord-316996-8yimrpaz	17	24	inhibited	inhibited	JJ
cord-316996-8yimrpaz	17	25	virus	virus	NN
cord-316996-8yimrpaz	17	26	adsorption	adsorption	NN
cord-316996-8yimrpaz	17	27	to	to	IN
cord-316996-8yimrpaz	17	28	surfaces	surface	NNS
cord-316996-8yimrpaz	17	29	(	(	-LRB-
cord-316996-8yimrpaz	17	30	Hanaoka	Hanaoka	NNP
cord-316996-8yimrpaz	17	31	et	et	NNP
cord-316996-8yimrpaz	17	32	al	al	NNP
cord-316996-8yimrpaz	17	33	.	.	NNP
cord-316996-8yimrpaz	17	34	,	,	,
cord-316996-8yimrpaz	17	35	1989	1989	CD
cord-316996-8yimrpaz	17	36	;	;	:
cord-316996-8yimrpaz	17	37	.	.	.
cord-316996-8yimrpaz	18	1	Later	later	JJ
cord-316996-8yimrpaz	18	2	studies	study	NNS
cord-316996-8yimrpaz	18	3	identified	identify	VBD
cord-316996-8yimrpaz	18	4	Sia	Sia	NNP
cord-316996-8yimrpaz	18	5	as	as	IN
cord-316996-8yimrpaz	18	6	being	be	VBG
cord-316996-8yimrpaz	18	7	the	the	DT
cord-316996-8yimrpaz	18	8	key	key	JJ
cord-316996-8yimrpaz	18	9	determinant	determinant	NN
cord-316996-8yimrpaz	18	10	of	of	IN
cord-316996-8yimrpaz	18	11	binding	bind	VBG
cord-316996-8yimrpaz	18	12	for	for	IN
cord-316996-8yimrpaz	18	13	these	these	DT
cord-316996-8yimrpaz	18	14	compounds	compound	NNS
cord-316996-8yimrpaz	18	15	(	(	-LRB-
cord-316996-8yimrpaz	18	16	Pritchett	Pritchett	NNP
cord-316996-8yimrpaz	18	17	et	et	NNP
cord-316996-8yimrpaz	18	18	al	al	NNP
cord-316996-8yimrpaz	18	19	.	.	NNP
cord-316996-8yimrpaz	18	20	,	,	,
cord-316996-8yimrpaz	18	21	1987	1987	CD
cord-316996-8yimrpaz	18	22	;	;	:
cord-316996-8yimrpaz	18	23	Pritchett	Pritchett	NNP
cord-316996-8yimrpaz	18	24	and	and	CC
cord-316996-8yimrpaz	18	25	Paulson	Paulson	NNP
cord-316996-8yimrpaz	18	26	,	,	,
cord-316996-8yimrpaz	18	27	1989	1989	CD
cord-316996-8yimrpaz	18	28	)	)	-RRB-
cord-316996-8yimrpaz	18	29	.	.	.
cord-316996-8yimrpaz	19	1	Lentz	Lentz	NNP
cord-316996-8yimrpaz	19	2	proposed	propose	VBD
cord-316996-8yimrpaz	19	3	a	a	DT
cord-316996-8yimrpaz	19	4	number	number	NN
cord-316996-8yimrpaz	19	5	of	of	IN
cord-316996-8yimrpaz	19	6	strategies	strategy	NNS
cord-316996-8yimrpaz	19	7	to	to	TO
cord-316996-8yimrpaz	19	8	prevent	prevent	VB
cord-316996-8yimrpaz	19	9	cell	cell	NN
cord-316996-8yimrpaz	19	10	entry	entry	NN
cord-316996-8yimrpaz	19	11	by	by	IN
cord-316996-8yimrpaz	19	12	blocking	block	VBG
cord-316996-8yimrpaz	19	13	the	the	DT
cord-316996-8yimrpaz	19	14	host	host	NN
cord-316996-8yimrpaz	19	15	receptor	receptor	NN
cord-316996-8yimrpaz	19	16	(	(	-LRB-
cord-316996-8yimrpaz	19	17	Lentz	Lentz	NNP
cord-316996-8yimrpaz	19	18	,	,	,
cord-316996-8yimrpaz	19	19	1988	1988	CD
cord-316996-8yimrpaz	19	20	(	(	-LRB-
cord-316996-8yimrpaz	19	21	Lentz	Lentz	NNP
cord-316996-8yimrpaz	19	22	,	,	,
cord-316996-8yimrpaz	19	23	,	,	,
cord-316996-8yimrpaz	19	24	1990	1990	CD
cord-316996-8yimrpaz	19	25	,	,	,
cord-316996-8yimrpaz	19	26	but	but	CC
cord-316996-8yimrpaz	19	27	these	these	DT
cord-316996-8yimrpaz	19	28	were	be	VBD
cord-316996-8yimrpaz	19	29	mainly	mainly	RB
cord-316996-8yimrpaz	19	30	directed	direct	VBN
cord-316996-8yimrpaz	19	31	at	at	IN
cord-316996-8yimrpaz	19	32	developing	develop	VBG
cord-316996-8yimrpaz	19	33	an	an	DT
cord-316996-8yimrpaz	19	34	antibody	antibody	NN
cord-316996-8yimrpaz	19	35	-	-	HYPH
cord-316996-8yimrpaz	19	36	mediated	mediate	VBN
cord-316996-8yimrpaz	19	37	approach	approach	NN
cord-316996-8yimrpaz	19	38	,	,	,
cord-316996-8yimrpaz	19	39	rather	rather	RB
cord-316996-8yimrpaz	19	40	than	than	IN
cord-316996-8yimrpaz	19	41	receptor	receptor	NN
cord-316996-8yimrpaz	19	42	destruction	destruction	NN
cord-316996-8yimrpaz	19	43	.	.	.
cord-316996-8yimrpaz	20	1	In	in	IN
cord-316996-8yimrpaz	20	2	1988	1988	CD
cord-316996-8yimrpaz	20	3	,	,	,
cord-316996-8yimrpaz	20	4	Weis	Weis	NNP
cord-316996-8yimrpaz	20	5	and	and	CC
cord-316996-8yimrpaz	20	6	colleague	colleague	NN
cord-316996-8yimrpaz	20	7	used	use	VBD
cord-316996-8yimrpaz	20	8	X	x	NN
cord-316996-8yimrpaz	20	9	-	-	NN
cord-316996-8yimrpaz	20	10	ray	ray	NN
cord-316996-8yimrpaz	20	11	crystallography	crystallography	NN
cord-316996-8yimrpaz	20	12	to	to	TO
cord-316996-8yimrpaz	20	13	map	map	VB
cord-316996-8yimrpaz	20	14	the	the	DT
cord-316996-8yimrpaz	20	15	haemagglutinin	haemagglutinin	JJ
cord-316996-8yimrpaz	20	16	-	-	HYPH
cord-316996-8yimrpaz	20	17	Sia	Sia	NNP
cord-316996-8yimrpaz	20	18	interaction	interaction	NN
cord-316996-8yimrpaz	20	19	(	(	-LRB-
cord-316996-8yimrpaz	20	20	Weis	Weis	NNP
cord-316996-8yimrpaz	20	21	et	et	NNP
cord-316996-8yimrpaz	20	22	al	al	NNP
cord-316996-8yimrpaz	20	23	.	.	NNP
cord-316996-8yimrpaz	20	24	,	,	,
cord-316996-8yimrpaz	20	25	1988	1988	CD
cord-316996-8yimrpaz	20	26	)	)	-RRB-
cord-316996-8yimrpaz	20	27	.	.	.
cord-316996-8yimrpaz	21	1	With	with	IN
cord-316996-8yimrpaz	21	2	this	this	DT
cord-316996-8yimrpaz	21	3	structure	structure	NN
cord-316996-8yimrpaz	21	4	solved	solve	VBD
cord-316996-8yimrpaz	21	5	,	,	,
cord-316996-8yimrpaz	21	6	it	-PRON-	PRP
cord-316996-8yimrpaz	21	7	was	be	VBD
cord-316996-8yimrpaz	21	8	envisioned	envision	VBN
cord-316996-8yimrpaz	21	9	that	that	IN
cord-316996-8yimrpaz	21	10	it	-PRON-	PRP
cord-316996-8yimrpaz	21	11	might	may	MD
cord-316996-8yimrpaz	21	12	be	be	VB
cord-316996-8yimrpaz	21	13	possible	possible	JJ
cord-316996-8yimrpaz	21	14	to	to	TO
cord-316996-8yimrpaz	21	15	develop	develop	VB
cord-316996-8yimrpaz	21	16	synthetic	synthetic	JJ
cord-316996-8yimrpaz	21	17	analogs	analog	NNS
cord-316996-8yimrpaz	21	18	of	of	IN
cord-316996-8yimrpaz	21	19	Sia	Sia	NNP
cord-316996-8yimrpaz	21	20	to	to	TO
cord-316996-8yimrpaz	21	21	block	block	VB
cord-316996-8yimrpaz	21	22	binding	bind	VBG
cord-316996-8yimrpaz	21	23	(	(	-LRB-
cord-316996-8yimrpaz	21	24	Pritchett	Pritchett	NNP
cord-316996-8yimrpaz	21	25	et	et	NNP
cord-316996-8yimrpaz	21	26	al	al	NNP
cord-316996-8yimrpaz	21	27	.	.	NNP
cord-316996-8yimrpaz	21	28	,	,	,
cord-316996-8yimrpaz	21	29	1987	1987	CD
cord-316996-8yimrpaz	21	30	;	;	:
cord-316996-8yimrpaz	21	31	Pritchett	Pritchett	NNP
cord-316996-8yimrpaz	21	32	and	and	CC
cord-316996-8yimrpaz	21	33	Paulson	Paulson	NNP
cord-316996-8yimrpaz	21	34	,	,	,
cord-316996-8yimrpaz	21	35	1989	1989	CD
cord-316996-8yimrpaz	21	36	)	)	-RRB-
cord-316996-8yimrpaz	21	37	,	,	,
cord-316996-8yimrpaz	21	38	though	though	IN
cord-316996-8yimrpaz	21	39	it	-PRON-	PRP
cord-316996-8yimrpaz	21	40	was	be	VBD
cord-316996-8yimrpaz	21	41	acknowledged	acknowledge	VBN
cord-316996-8yimrpaz	21	42	that	that	IN
cord-316996-8yimrpaz	21	43	such	such	JJ
cord-316996-8yimrpaz	21	44	drug	drug	NN
cord-316996-8yimrpaz	21	45	design	design	NN
cord-316996-8yimrpaz	21	46	would	would	MD
cord-316996-8yimrpaz	21	47	have	have	VB
cord-316996-8yimrpaz	21	48	a	a	DT
cord-316996-8yimrpaz	21	49	number	number	NN
cord-316996-8yimrpaz	21	50	of	of	IN
cord-316996-8yimrpaz	21	51	structural	structural	JJ
cord-316996-8yimrpaz	21	52	obstacles	obstacle	NNS
cord-316996-8yimrpaz	21	53	(	(	-LRB-
cord-316996-8yimrpaz	21	54	Weis	Weis	NNP
cord-316996-8yimrpaz	21	55	et	et	NNP
cord-316996-8yimrpaz	21	56	al	al	NNP
cord-316996-8yimrpaz	21	57	.	.	NNP
cord-316996-8yimrpaz	21	58	,	,	,
cord-316996-8yimrpaz	21	59	1988	1988	CD
cord-316996-8yimrpaz	21	60	)	)	-RRB-
cord-316996-8yimrpaz	21	61	.	.	.
cord-316996-8yimrpaz	22	1	This	this	DT
cord-316996-8yimrpaz	22	2	route	route	NN
cord-316996-8yimrpaz	22	3	of	of	IN
cord-316996-8yimrpaz	22	4	anti	anti	JJ
cord-316996-8yimrpaz	22	5	-	-	JJ
cord-316996-8yimrpaz	22	6	influenza	influenza	JJ
cord-316996-8yimrpaz	22	7	therapy	therapy	NN
cord-316996-8yimrpaz	22	8	was	be	VBD
cord-316996-8yimrpaz	22	9	not	not	RB
cord-316996-8yimrpaz	22	10	pursued	pursue	VBN
cord-316996-8yimrpaz	22	11	in	in	IN
cord-316996-8yimrpaz	22	12	as	as	RB
cord-316996-8yimrpaz	22	13	much	much	JJ
cord-316996-8yimrpaz	22	14	detail	detail	NN
cord-316996-8yimrpaz	22	15	as	as	IN
cord-316996-8yimrpaz	22	16	blocking	block	VBG
cord-316996-8yimrpaz	22	17	the	the	DT
cord-316996-8yimrpaz	22	18	viral	viral	JJ
cord-316996-8yimrpaz	22	19	neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	22	20	site	site	NN
cord-316996-8yimrpaz	22	21	,	,	,
cord-316996-8yimrpaz	22	22	but	but	CC
cord-316996-8yimrpaz	22	23	there	there	EX
cord-316996-8yimrpaz	22	24	have	have	VBP
cord-316996-8yimrpaz	22	25	been	be	VBN
cord-316996-8yimrpaz	22	26	two	two	CD
cord-316996-8yimrpaz	22	27	recent	recent	JJ
cord-316996-8yimrpaz	22	28	reports	report	NNS
cord-316996-8yimrpaz	22	29	on	on	IN
cord-316996-8yimrpaz	22	30	developing	develop	VBG
cord-316996-8yimrpaz	22	31	drug	drug	NN
cord-316996-8yimrpaz	22	32	design	design	NN
cord-316996-8yimrpaz	22	33	by	by	IN
cord-316996-8yimrpaz	22	34	blocking	block	VBG
cord-316996-8yimrpaz	22	35	the	the	DT
cord-316996-8yimrpaz	22	36	HA	HA	NNP
cord-316996-8yimrpaz	22	37	binding	binding	NN
cord-316996-8yimrpaz	22	38	site	site	NN
cord-316996-8yimrpaz	22	39	,	,	,
cord-316996-8yimrpaz	22	40	using	use	VBG
cord-316996-8yimrpaz	22	41	databases	database	NNS
cord-316996-8yimrpaz	22	42	of	of	IN
cord-316996-8yimrpaz	22	43	commercially	commercially	RB
cord-316996-8yimrpaz	22	44	available	available	JJ
cord-316996-8yimrpaz	22	45	compounds	compound	NNS
cord-316996-8yimrpaz	22	46	(	(	-LRB-
cord-316996-8yimrpaz	22	47	ZINC	zinc	NN
cord-316996-8yimrpaz	22	48	)	)	-RRB-
cord-316996-8yimrpaz	22	49	Nandi	Nandi	NNP
cord-316996-8yimrpaz	22	50	,	,	,
cord-316996-8yimrpaz	22	51	2008	2008	CD
cord-316996-8yimrpaz	22	52	)	)	-RRB-
cord-316996-8yimrpaz	22	53	and	and	CC
cord-316996-8yimrpaz	22	54	other	other	JJ
cord-316996-8yimrpaz	22	55	techniques	technique	NNS
cord-316996-8yimrpaz	22	56	(	(	-LRB-
cord-316996-8yimrpaz	22	57	Al	Al	NNP
cord-316996-8yimrpaz	22	58	-	-	HYPH
cord-316996-8yimrpaz	22	59	qattan	qattan	NNP
cord-316996-8yimrpaz	22	60	and	and	CC
cord-316996-8yimrpaz	22	61	Mordi	Mordi	NNP
cord-316996-8yimrpaz	22	62	,	,	,
cord-316996-8yimrpaz	22	63	2010a	2010a	NNS
cord-316996-8yimrpaz	22	64	,	,	,
cord-316996-8yimrpaz	22	65	b	b	LS
cord-316996-8yimrpaz	22	66	;	;	:
cord-316996-8yimrpaz	22	67	Blessia	Blessia	NNP
cord-316996-8yimrpaz	22	68	et	et	NNP
cord-316996-8yimrpaz	22	69	al	al	NNP
cord-316996-8yimrpaz	22	70	.	.	NNP
cord-316996-8yimrpaz	22	71	,	,	,
cord-316996-8yimrpaz	22	72	2010	2010	CD
cord-316996-8yimrpaz	22	73	)	)	-RRB-
cord-316996-8yimrpaz	22	74	.	.	.
cord-316996-8yimrpaz	23	1	In	in	IN
cord-316996-8yimrpaz	23	2	1958	1958	CD
cord-316996-8yimrpaz	23	3	,	,	,
cord-316996-8yimrpaz	23	4	Springer	Springer	NNP
cord-316996-8yimrpaz	23	5	and	and	CC
cord-316996-8yimrpaz	23	6	Ansell	Ansell	NNP
cord-316996-8yimrpaz	23	7	found	find	VBD
cord-316996-8yimrpaz	23	8	that	that	IN
cord-316996-8yimrpaz	23	9	influenza	influenza	NN
cord-316996-8yimrpaz	23	10	viruses	virus	NNS
cord-316996-8yimrpaz	23	11	and	and	CC
cord-316996-8yimrpaz	23	12	bacteria	bacteria	NNS
cord-316996-8yimrpaz	23	13	had	have	VBD
cord-316996-8yimrpaz	23	14	a	a	DT
cord-316996-8yimrpaz	23	15	common	common	JJ
cord-316996-8yimrpaz	23	16	enzyme	enzyme	NN
cord-316996-8yimrpaz	23	17	property	property	NN
cord-316996-8yimrpaz	23	18	:	:	:
cord-316996-8yimrpaz	23	19	the	the	DT
cord-316996-8yimrpaz	23	20	ability	ability	NN
cord-316996-8yimrpaz	23	21	to	to	TO
cord-316996-8yimrpaz	23	22	remove	remove	VB
cord-316996-8yimrpaz	23	23	recep	recep	NNP
cord-316996-8yimrpaz	23	24	-	-	HYPH
cord-316996-8yimrpaz	23	25	tors	tor	NNS
cord-316996-8yimrpaz	23	26	from	from	IN
cord-316996-8yimrpaz	23	27	red	red	JJ
cord-316996-8yimrpaz	23	28	blood	blood	NN
cord-316996-8yimrpaz	23	29	cells	cell	NNS
cord-316996-8yimrpaz	23	30	and	and	CC
cord-316996-8yimrpaz	23	31	prevent	prevent	VBP
cord-316996-8yimrpaz	23	32	haemagglutination	haemagglutination	NN
cord-316996-8yimrpaz	23	33	(	(	-LRB-
cord-316996-8yimrpaz	23	34	Springer	Springer	NNP
cord-316996-8yimrpaz	23	35	and	and	CC
cord-316996-8yimrpaz	23	36	Ansell	Ansell	NNP
cord-316996-8yimrpaz	23	37	,	,	,
cord-316996-8yimrpaz	23	38	1958	1958	CD
cord-316996-8yimrpaz	23	39	)	)	-RRB-
cord-316996-8yimrpaz	23	40	.	.	.
cord-316996-8yimrpaz	24	1	To	to	TO
cord-316996-8yimrpaz	24	2	investigate	investigate	VB
cord-316996-8yimrpaz	24	3	this	this	DT
cord-316996-8yimrpaz	24	4	requires	require	VBZ
cord-316996-8yimrpaz	24	5	an	an	DT
cord-316996-8yimrpaz	24	6	understanding	understanding	NN
cord-316996-8yimrpaz	24	7	of	of	IN
cord-316996-8yimrpaz	24	8	the	the	DT
cord-316996-8yimrpaz	24	9	nature	nature	NN
cord-316996-8yimrpaz	24	10	of	of	IN
cord-316996-8yimrpaz	24	11	Sia	Sia	NNP
cord-316996-8yimrpaz	24	12	,	,	,
cord-316996-8yimrpaz	24	13	its	-PRON-	PRP$
cord-316996-8yimrpaz	24	14	presence	presence	NN
cord-316996-8yimrpaz	24	15	in	in	IN
cord-316996-8yimrpaz	24	16	the	the	DT
cord-316996-8yimrpaz	24	17	respiratory	respiratory	JJ
cord-316996-8yimrpaz	24	18	tract	tract	NN
cord-316996-8yimrpaz	24	19	and	and	CC
cord-316996-8yimrpaz	24	20	the	the	DT
cord-316996-8yimrpaz	24	21	structure	structure	NN
cord-316996-8yimrpaz	24	22	and	and	CC
cord-316996-8yimrpaz	24	23	function	function	NN
cord-316996-8yimrpaz	24	24	of	of	IN
cord-316996-8yimrpaz	24	25	bacterial	bacterial	JJ
cord-316996-8yimrpaz	24	26	sialidase	sialidase	NN
cord-316996-8yimrpaz	24	27	.	.	.
cord-316996-8yimrpaz	25	1	Sialic	Sialic	NNP
cord-316996-8yimrpaz	25	2	acid	acid	NN
cord-316996-8yimrpaz	25	3	is	be	VBZ
cord-316996-8yimrpaz	25	4	the	the	DT
cord-316996-8yimrpaz	25	5	term	term	NN
cord-316996-8yimrpaz	25	6	used	use	VBN
cord-316996-8yimrpaz	25	7	for	for	IN
cord-316996-8yimrpaz	25	8	a	a	DT
cord-316996-8yimrpaz	25	9	family	family	NN
cord-316996-8yimrpaz	25	10	of	of	IN
cord-316996-8yimrpaz	25	11	nine	nine	CD
cord-316996-8yimrpaz	25	12	-	-	HYPH
cord-316996-8yimrpaz	25	13	carbon	carbon	NN
cord-316996-8yimrpaz	25	14	monoscaccharides	monoscaccharide	NNS
cord-316996-8yimrpaz	25	15	found	find	VBN
cord-316996-8yimrpaz	25	16	in	in	IN
cord-316996-8yimrpaz	25	17	animals	animal	NNS
cord-316996-8yimrpaz	25	18	and	and	CC
cord-316996-8yimrpaz	25	19	certain	certain	JJ
cord-316996-8yimrpaz	25	20	bacteria	bacteria	NNS
cord-316996-8yimrpaz	25	21	(	(	-LRB-
cord-316996-8yimrpaz	25	22	Chen	Chen	NNP
cord-316996-8yimrpaz	25	23	and	and	CC
cord-316996-8yimrpaz	25	24	Varki	Varki	NNP
cord-316996-8yimrpaz	25	25	,	,	,
cord-316996-8yimrpaz	25	26	2010	2010	CD
cord-316996-8yimrpaz	25	27	)	)	-RRB-
cord-316996-8yimrpaz	25	28	.	.	.
cord-316996-8yimrpaz	26	1	They	-PRON-	PRP
cord-316996-8yimrpaz	26	2	are	be	VBP
cord-316996-8yimrpaz	26	3	typically	typically	RB
cord-316996-8yimrpaz	26	4	found	find	VBN
cord-316996-8yimrpaz	26	5	at	at	IN
cord-316996-8yimrpaz	26	6	the	the	DT
cord-316996-8yimrpaz	26	7	terminal	terminal	JJ
cord-316996-8yimrpaz	26	8	portions	portion	NNS
cord-316996-8yimrpaz	26	9	of	of	IN
cord-316996-8yimrpaz	26	10	oligosaccharide	oligosaccharide	NN
cord-316996-8yimrpaz	26	11	chains	chain	NNS
cord-316996-8yimrpaz	26	12	attached	attach	VBN
cord-316996-8yimrpaz	26	13	to	to	IN
cord-316996-8yimrpaz	26	14	proteins	protein	NNS
cord-316996-8yimrpaz	26	15	and	and	CC
cord-316996-8yimrpaz	26	16	lipids	lipid	NNS
cord-316996-8yimrpaz	26	17	to	to	TO
cord-316996-8yimrpaz	26	18	form	form	VB
cord-316996-8yimrpaz	26	19	glycoproteins	glycoprotein	NNS
cord-316996-8yimrpaz	26	20	and	and	CC
cord-316996-8yimrpaz	26	21	glycolipids	glycolipid	NNS
cord-316996-8yimrpaz	26	22	,	,	,
cord-316996-8yimrpaz	26	23	respectively	respectively	RB
cord-316996-8yimrpaz	26	24	.	.	.
cord-316996-8yimrpaz	27	1	There	there	EX
cord-316996-8yimrpaz	27	2	are	be	VBP
cord-316996-8yimrpaz	27	3	over	over	IN
cord-316996-8yimrpaz	27	4	40	40	CD
cord-316996-8yimrpaz	27	5	naturally	naturally	RB
cord-316996-8yimrpaz	27	6	occurring	occur	VBG
cord-316996-8yimrpaz	27	7	variants	variant	NNS
cord-316996-8yimrpaz	27	8	of	of	IN
cord-316996-8yimrpaz	27	9	these	these	DT
cord-316996-8yimrpaz	27	10	nine	nine	CD
cord-316996-8yimrpaz	27	11	-	-	HYPH
cord-316996-8yimrpaz	27	12	carbon	carbon	NN
cord-316996-8yimrpaz	27	13	keto	keto	NN
cord-316996-8yimrpaz	27	14	-	-	HYPH
cord-316996-8yimrpaz	27	15	sugars	sugar	NNS
cord-316996-8yimrpaz	27	16	based	base	VBN
cord-316996-8yimrpaz	27	17	on	on	IN
cord-316996-8yimrpaz	27	18	a	a	DT
cord-316996-8yimrpaz	27	19	neuraminic	neuraminic	JJ
cord-316996-8yimrpaz	27	20	acid	acid	NN
cord-316996-8yimrpaz	27	21	(	(	-LRB-
cord-316996-8yimrpaz	27	22	Neu	Neu	NNP
cord-316996-8yimrpaz	27	23	)	)	-RRB-
cord-316996-8yimrpaz	27	24	or	or	CC
cord-316996-8yimrpaz	27	25	a	a	DT
cord-316996-8yimrpaz	27	26	2-keto-3-deoxynononic	2-keto-3-deoxynononic	CD
cord-316996-8yimrpaz	27	27	acid	acid	NN
cord-316996-8yimrpaz	27	28	(	(	-LRB-
cord-316996-8yimrpaz	27	29	Kdn	kdn	NN
cord-316996-8yimrpaz	27	30	)	)	-RRB-
cord-316996-8yimrpaz	27	31	backbone	backbone	NN
cord-316996-8yimrpaz	27	32	(	(	-LRB-
cord-316996-8yimrpaz	27	33	Schauer	Schauer	NNP
cord-316996-8yimrpaz	27	34	,	,	,
cord-316996-8yimrpaz	27	35	1973	1973	CD
cord-316996-8yimrpaz	27	36	;	;	:
cord-316996-8yimrpaz	27	37	Varki	Varki	NNP
cord-316996-8yimrpaz	27	38	,	,	,
cord-316996-8yimrpaz	27	39	1997	1997	CD
cord-316996-8yimrpaz	27	40	)	)	-RRB-
cord-316996-8yimrpaz	27	41	.	.	.
cord-316996-8yimrpaz	28	1	The	the	DT
cord-316996-8yimrpaz	28	2	discovery	discovery	NN
cord-316996-8yimrpaz	28	3	of	of	IN
cord-316996-8yimrpaz	28	4	neuraminic	neuraminic	JJ
cord-316996-8yimrpaz	28	5	acid	acid	NN
cord-316996-8yimrpaz	28	6	by	by	IN
cord-316996-8yimrpaz	28	7	Klenk	Klenk	NNP
cord-316996-8yimrpaz	28	8	and	and	CC
cord-316996-8yimrpaz	28	9	colleagues	colleague	NNS
cord-316996-8yimrpaz	28	10	has	have	VBZ
cord-316996-8yimrpaz	28	11	been	be	VBN
cord-316996-8yimrpaz	28	12	reviewed	review	VBN
cord-316996-8yimrpaz	28	13	by	by	IN
cord-316996-8yimrpaz	28	14	Schaeur	Schaeur	NNP
cord-316996-8yimrpaz	28	15	(	(	-LRB-
cord-316996-8yimrpaz	28	16	Schauer	Schauer	NNP
cord-316996-8yimrpaz	28	17	,	,	,
cord-316996-8yimrpaz	28	18	1973	1973	CD
cord-316996-8yimrpaz	28	19	)	)	-RRB-
cord-316996-8yimrpaz	28	20	with	with	IN
cord-316996-8yimrpaz	28	21	the	the	DT
cord-316996-8yimrpaz	28	22	term	term	NN
cord-316996-8yimrpaz	28	23	sialic	sialic	NN
cord-316996-8yimrpaz	28	24	acid	acid	NN
cord-316996-8yimrpaz	28	25	proposed	propose	VBN
cord-316996-8yimrpaz	28	26	by	by	IN
cord-316996-8yimrpaz	28	27	Blix	Blix	NNP
cord-316996-8yimrpaz	28	28	,	,	,
cord-316996-8yimrpaz	28	29	Gottschalk	Gottschalk	NNP
cord-316996-8yimrpaz	28	30	and	and	CC
cord-316996-8yimrpaz	28	31	Klenk	Klenk	NNP
cord-316996-8yimrpaz	28	32	based	base	VBN
cord-316996-8yimrpaz	28	33	on	on	IN
cord-316996-8yimrpaz	28	34	the	the	DT
cord-316996-8yimrpaz	28	35	Greek	greek	JJ
cord-316996-8yimrpaz	28	36	word	word	NN
cord-316996-8yimrpaz	28	37	sialion	sialion	NN
cord-316996-8yimrpaz	28	38	(	(	-LRB-
cord-316996-8yimrpaz	28	39	salivea	salivea	NN
cord-316996-8yimrpaz	28	40	)	)	-RRB-
cord-316996-8yimrpaz	28	41	as	as	IN
cord-316996-8yimrpaz	28	42	these	these	DT
cord-316996-8yimrpaz	28	43	carbohydrates	carbohydrate	NNS
cord-316996-8yimrpaz	28	44	were	be	VBD
cord-316996-8yimrpaz	28	45	isolated	isolate	VBN
cord-316996-8yimrpaz	28	46	from	from	IN
cord-316996-8yimrpaz	28	47	the	the	DT
cord-316996-8yimrpaz	28	48	mucin	mucin	NN
cord-316996-8yimrpaz	28	49	of	of	IN
cord-316996-8yimrpaz	28	50	submaxillary	submaxillary	JJ
cord-316996-8yimrpaz	28	51	glands	gland	NNS
cord-316996-8yimrpaz	28	52	.	.	.
cord-316996-8yimrpaz	29	1	2.2	2.2	CD
cord-316996-8yimrpaz	29	2	.	.	.
cord-316996-8yimrpaz	30	1	Sialic	Sialic	NNP
cord-316996-8yimrpaz	30	2	acid	acid	NN
cord-316996-8yimrpaz	30	3	:	:	:
cord-316996-8yimrpaz	30	4	structure	structure	NN
cord-316996-8yimrpaz	30	5	and	and	CC
cord-316996-8yimrpaz	30	6	function	function	VB
cord-316996-8yimrpaz	30	7	2.2.1	2.2.1	CD
cord-316996-8yimrpaz	30	8	.	.	.
cord-316996-8yimrpaz	31	1	Sialic	Sialic	NNP
cord-316996-8yimrpaz	31	2	acid	acid	NN
cord-316996-8yimrpaz	31	3	structure	structure	NN
cord-316996-8yimrpaz	32	1	The	the	DT
cord-316996-8yimrpaz	32	2	diversity	diversity	NN
cord-316996-8yimrpaz	32	3	of	of	IN
cord-316996-8yimrpaz	32	4	Sia	Sia	NNP
cord-316996-8yimrpaz	32	5	present	present	JJ
cord-316996-8yimrpaz	32	6	in	in	IN
cord-316996-8yimrpaz	32	7	nature	nature	NN
cord-316996-8yimrpaz	32	8	is	be	VBZ
cord-316996-8yimrpaz	32	9	due	due	JJ
cord-316996-8yimrpaz	32	10	to	to	IN
cord-316996-8yimrpaz	32	11	the	the	DT
cord-316996-8yimrpaz	32	12	substitution	substitution	NN
cord-316996-8yimrpaz	32	13	at	at	IN
cord-316996-8yimrpaz	32	14	the	the	DT
cord-316996-8yimrpaz	32	15	4	4	CD
cord-316996-8yimrpaz	32	16	-	-	SYM
cord-316996-8yimrpaz	32	17	9	9	CD
cord-316996-8yimrpaz	32	18	carbons	carbon	NNS
cord-316996-8yimrpaz	32	19	by	by	IN
cord-316996-8yimrpaz	32	20	O	o	NN
cord-316996-8yimrpaz	32	21	-	-	HYPH
cord-316996-8yimrpaz	32	22	acetyl	acetyl	NN
cord-316996-8yimrpaz	32	23	,	,	,
cord-316996-8yimrpaz	32	24	sulfate	sulfate	NN
cord-316996-8yimrpaz	32	25	,	,	,
cord-316996-8yimrpaz	32	26	methyl	methyl	NN
cord-316996-8yimrpaz	32	27	and	and	CC
cord-316996-8yimrpaz	32	28	lactate	lactate	NN
cord-316996-8yimrpaz	32	29	groups	group	NNS
cord-316996-8yimrpaz	32	30	and	and	CC
cord-316996-8yimrpaz	32	31	by	by	IN
cord-316996-8yimrpaz	32	32	glycosidic	glycosidic	JJ
cord-316996-8yimrpaz	32	33	linkage	linkage	NN
cord-316996-8yimrpaz	32	34	by	by	IN
cord-316996-8yimrpaz	32	35	the	the	DT
cord-316996-8yimrpaz	32	36	anomeric	anomeric	NN
cord-316996-8yimrpaz	32	37	C	C	NNP
cord-316996-8yimrpaz	32	38	2	2	CD
cord-316996-8yimrpaz	32	39	to	to	IN
cord-316996-8yimrpaz	32	40	the	the	DT
cord-316996-8yimrpaz	32	41	3	3	CD
cord-316996-8yimrpaz	32	42	or	or	CC
cord-316996-8yimrpaz	32	43	6	6	CD
cord-316996-8yimrpaz	32	44	hydroxyl	hydroxyl	NN
cord-316996-8yimrpaz	32	45	group	group	NN
cord-316996-8yimrpaz	32	46	of	of	IN
cord-316996-8yimrpaz	32	47	galactose	galactose	NN
cord-316996-8yimrpaz	32	48	(	(	-LRB-
cord-316996-8yimrpaz	32	49	Gal	Gal	NNP
cord-316996-8yimrpaz	32	50	)	)	-RRB-
cord-316996-8yimrpaz	32	51	(	(	-LRB-
cord-316996-8yimrpaz	32	52	referred	refer	VBN
cord-316996-8yimrpaz	32	53	to	to	IN
cord-316996-8yimrpaz	32	54	as	as	IN
cord-316996-8yimrpaz	32	55	the	the	DT
cord-316996-8yimrpaz	32	56	a2	a2	NNP
cord-316996-8yimrpaz	32	57	-	-	HYPH
cord-316996-8yimrpaz	32	58	3	3	CD
cord-316996-8yimrpaz	32	59	or	or	CC
cord-316996-8yimrpaz	32	60	a2	a2	NNP
cord-316996-8yimrpaz	32	61	-	-	HYPH
cord-316996-8yimrpaz	32	62	6	6	CD
cord-316996-8yimrpaz	32	63	)	)	-RRB-
cord-316996-8yimrpaz	32	64	,	,	,
cord-316996-8yimrpaz	32	65	N	n	CD
cord-316996-8yimrpaz	32	66	-	-	HYPH
cord-316996-8yimrpaz	32	67	acetyl	acetyl	NNP
cord-316996-8yimrpaz	32	68	galactosamine	galactosamine	NN
cord-316996-8yimrpaz	32	69	(	(	-LRB-
cord-316996-8yimrpaz	32	70	GalNAc	GalNAc	NNP
cord-316996-8yimrpaz	32	71	)	)	-RRB-
cord-316996-8yimrpaz	32	72	or	or	CC
cord-316996-8yimrpaz	32	73	N	n	CD
cord-316996-8yimrpaz	32	74	-	-	HYPH
cord-316996-8yimrpaz	32	75	acetyl	acetyl	NN
cord-316996-8yimrpaz	32	76	glucosamine	glucosamine	NN
cord-316996-8yimrpaz	32	77	(	(	-LRB-
cord-316996-8yimrpaz	32	78	GlcNAc	GlcNAc	NNP
cord-316996-8yimrpaz	32	79	)	)	-RRB-
cord-316996-8yimrpaz	33	1	(	(	-LRB-
cord-316996-8yimrpaz	33	2	Varki	Varki	NNP
cord-316996-8yimrpaz	33	3	and	and	CC
cord-316996-8yimrpaz	33	4	Varki	Varki	NNP
cord-316996-8yimrpaz	33	5	,	,	,
cord-316996-8yimrpaz	33	6	2007	2007	CD
cord-316996-8yimrpaz	33	7	)	)	-RRB-
cord-316996-8yimrpaz	34	1	(	(	-LRB-
cord-316996-8yimrpaz	34	2	Fig	Fig	NNP
cord-316996-8yimrpaz	34	3	.	.	NNP
cord-316996-8yimrpaz	34	4	1	1	CD
cord-316996-8yimrpaz	34	5	)	)	-RRB-
cord-316996-8yimrpaz	34	6	.	.	.
cord-316996-8yimrpaz	35	1	Eleven	eleven	CD
cord-316996-8yimrpaz	35	2	different	different	JJ
cord-316996-8yimrpaz	35	3	types	type	NNS
cord-316996-8yimrpaz	35	4	of	of	IN
cord-316996-8yimrpaz	35	5	sialic	sialic	JJ
cord-316996-8yimrpaz	35	6	acid	acid	NN
cord-316996-8yimrpaz	35	7	have	have	VBP
cord-316996-8yimrpaz	35	8	been	be	VBN
cord-316996-8yimrpaz	35	9	identified	identify	VBN
cord-316996-8yimrpaz	35	10	on	on	IN
cord-316996-8yimrpaz	35	11	the	the	DT
cord-316996-8yimrpaz	35	12	human	human	JJ
cord-316996-8yimrpaz	35	13	erythrocyte	erythrocyte	NN
cord-316996-8yimrpaz	35	14	membrane	membrane	NN
cord-316996-8yimrpaz	35	15	,	,	,
cord-316996-8yimrpaz	35	16	using	use	VBG
cord-316996-8yimrpaz	35	17	gas	gas	NN
cord-316996-8yimrpaz	35	18	chromatography	chromatography	NN
cord-316996-8yimrpaz	35	19	and	and	CC
cord-316996-8yimrpaz	35	20	mass	mass	NN
cord-316996-8yimrpaz	35	21	spectrometry	spectrometry	NN
cord-316996-8yimrpaz	35	22	(	(	-LRB-
cord-316996-8yimrpaz	35	23	Bulai	Bulai	NNP
cord-316996-8yimrpaz	35	24	et	et	NNP
cord-316996-8yimrpaz	35	25	al	al	NNP
cord-316996-8yimrpaz	35	26	.	.	NNP
cord-316996-8yimrpaz	35	27	,	,	,
cord-316996-8yimrpaz	35	28	2003	2003	CD
cord-316996-8yimrpaz	35	29	)	)	-RRB-
cord-316996-8yimrpaz	35	30	.	.	.
cord-316996-8yimrpaz	36	1	GalNAc	GalNAc	NNP
cord-316996-8yimrpaz	36	2	is	be	VBZ
cord-316996-8yimrpaz	36	3	typically	typically	RB
cord-316996-8yimrpaz	36	4	present	present	JJ
cord-316996-8yimrpaz	36	5	on	on	IN
cord-316996-8yimrpaz	36	6	O	o	NN
cord-316996-8yimrpaz	36	7	-	-	HYPH
cord-316996-8yimrpaz	36	8	glycans	glycan	NNS
cord-316996-8yimrpaz	36	9	,	,	,
cord-316996-8yimrpaz	36	10	and	and	CC
cord-316996-8yimrpaz	36	11	GlcNAc	GlcNAc	NNP
cord-316996-8yimrpaz	36	12	is	be	VBZ
cord-316996-8yimrpaz	36	13	normally	normally	RB
cord-316996-8yimrpaz	36	14	a	a	DT
cord-316996-8yimrpaz	36	15	component	component	NN
cord-316996-8yimrpaz	36	16	of	of	IN
cord-316996-8yimrpaz	36	17	N	n	NN
cord-316996-8yimrpaz	36	18	-	-	HYPH
cord-316996-8yimrpaz	36	19	glycans	glycan	NNS
cord-316996-8yimrpaz	36	20	.	.	.
cord-316996-8yimrpaz	37	1	The	the	DT
cord-316996-8yimrpaz	37	2	binding	binding	NN
cord-316996-8yimrpaz	37	3	of	of	IN
cord-316996-8yimrpaz	37	4	Sia	Sia	NNP
cord-316996-8yimrpaz	37	5	to	to	IN
cord-316996-8yimrpaz	37	6	Gal	Gal	NNP
cord-316996-8yimrpaz	37	7	or	or	CC
cord-316996-8yimrpaz	37	8	GalNAc	galnac	NN
cord-316996-8yimrpaz	37	9	requires	require	VBZ
cord-316996-8yimrpaz	37	10	a	a	DT
cord-316996-8yimrpaz	37	11	family	family	NN
cord-316996-8yimrpaz	37	12	of	of	IN
cord-316996-8yimrpaz	37	13	enzymes	enzyme	NNS
cord-316996-8yimrpaz	37	14	called	call	VBN
cord-316996-8yimrpaz	37	15	sialyltransferases	sialyltransferase	NNS
cord-316996-8yimrpaz	37	16	(	(	-LRB-
cord-316996-8yimrpaz	37	17	ST	ST	NNP
cord-316996-8yimrpaz	37	18	)	)	-RRB-
cord-316996-8yimrpaz	37	19	,	,	,
cord-316996-8yimrpaz	37	20	with	with	IN
cord-316996-8yimrpaz	37	21	each	each	DT
cord-316996-8yimrpaz	37	22	ST	ST	NNP
cord-316996-8yimrpaz	37	23	producing	produce	VBG
cord-316996-8yimrpaz	37	24	a	a	DT
cord-316996-8yimrpaz	37	25	specific	specific	JJ
cord-316996-8yimrpaz	37	26	linkage	linkage	NN
cord-316996-8yimrpaz	37	27	(	(	-LRB-
cord-316996-8yimrpaz	37	28	Harduin	Harduin	NNP
cord-316996-8yimrpaz	37	29	-	-	HYPH
cord-316996-8yimrpaz	37	30	Lepers	Lepers	NNP
cord-316996-8yimrpaz	37	31	et	et	FW
cord-316996-8yimrpaz	37	32	al	al	NNP
cord-316996-8yimrpaz	37	33	.	.	NNP
cord-316996-8yimrpaz	37	34	,	,	,
cord-316996-8yimrpaz	37	35	2005	2005	CD
cord-316996-8yimrpaz	37	36	;	;	:
cord-316996-8yimrpaz	37	37	Paulson	Paulson	NNP
cord-316996-8yimrpaz	37	38	and	and	CC
cord-316996-8yimrpaz	37	39	Rademacher	Rademacher	NNP
cord-316996-8yimrpaz	37	40	,	,	,
cord-316996-8yimrpaz	37	41	2009	2009	CD
cord-316996-8yimrpaz	37	42	;	;	.
cord-316996-8yimrpaz	38	1	Xia	Xia	NNP
cord-316996-8yimrpaz	38	2	et	et	NNP
cord-316996-8yimrpaz	38	3	al	al	NNP
cord-316996-8yimrpaz	38	4	.	.	NNP
cord-316996-8yimrpaz	38	5	,	,	,
cord-316996-8yimrpaz	38	6	2005	2005	CD
cord-316996-8yimrpaz	38	7	)	)	-RRB-
cord-316996-8yimrpaz	38	8	.	.	.
cord-316996-8yimrpaz	39	1	In	in	IN
cord-316996-8yimrpaz	39	2	some	some	DT
cord-316996-8yimrpaz	39	3	instances	instance	NNS
cord-316996-8yimrpaz	39	4	,	,	,
cord-316996-8yimrpaz	39	5	multiple	multiple	JJ
cord-316996-8yimrpaz	39	6	Sia	Sia	NNP
cord-316996-8yimrpaz	39	7	may	may	MD
cord-316996-8yimrpaz	39	8	be	be	VB
cord-316996-8yimrpaz	39	9	linked	link	VBN
cord-316996-8yimrpaz	39	10	together	together	RB
cord-316996-8yimrpaz	39	11	to	to	TO
cord-316996-8yimrpaz	39	12	form	form	VB
cord-316996-8yimrpaz	39	13	polysialic	polysialic	JJ
cord-316996-8yimrpaz	39	14	acid	acid	NN
cord-316996-8yimrpaz	39	15	,	,	,
cord-316996-8yimrpaz	39	16	most	most	RBS
cord-316996-8yimrpaz	39	17	commonly	commonly	RB
cord-316996-8yimrpaz	39	18	in	in	IN
cord-316996-8yimrpaz	39	19	a	a	DT
cord-316996-8yimrpaz	39	20	a2	a2	NNP
cord-316996-8yimrpaz	39	21	-	-	HYPH
cord-316996-8yimrpaz	39	22	8	8	CD
cord-316996-8yimrpaz	39	23	configuration	configuration	NN
cord-316996-8yimrpaz	40	1	(	(	-LRB-
cord-316996-8yimrpaz	40	2	Hildebrandt	Hildebrandt	NNP
cord-316996-8yimrpaz	40	3	et	et	NNP
cord-316996-8yimrpaz	40	4	al	al	NNP
cord-316996-8yimrpaz	40	5	.	.	NNP
cord-316996-8yimrpaz	40	6	,	,	,
cord-316996-8yimrpaz	40	7	2010	2010	CD
cord-316996-8yimrpaz	40	8	)	)	-RRB-
cord-316996-8yimrpaz	40	9	.	.	.
cord-316996-8yimrpaz	41	1	The	the	DT
cord-316996-8yimrpaz	41	2	linkage	linkage	NN
cord-316996-8yimrpaz	41	3	of	of	IN
cord-316996-8yimrpaz	41	4	Sia	Sia	NNP
cord-316996-8yimrpaz	41	5	to	to	IN
cord-316996-8yimrpaz	41	6	the	the	DT
cord-316996-8yimrpaz	41	7	adjacent	adjacent	JJ
cord-316996-8yimrpaz	41	8	sugar	sugar	NN
cord-316996-8yimrpaz	41	9	is	be	VBZ
cord-316996-8yimrpaz	41	10	in	in	IN
cord-316996-8yimrpaz	41	11	an	an	DT
cord-316996-8yimrpaz	41	12	a	a	DT
cord-316996-8yimrpaz	41	13	configuration	configuration	NN
cord-316996-8yimrpaz	41	14	,	,	,
cord-316996-8yimrpaz	41	15	which	which	WDT
cord-316996-8yimrpaz	41	16	means	mean	VBZ
cord-316996-8yimrpaz	41	17	the	the	DT
cord-316996-8yimrpaz	41	18	bond	bond	NN
cord-316996-8yimrpaz	41	19	is	be	VBZ
cord-316996-8yimrpaz	41	20	acid	acid	NN
cord-316996-8yimrpaz	41	21	-	-	HYPH
cord-316996-8yimrpaz	41	22	labile	labile	JJ
cord-316996-8yimrpaz	41	23	and	and	CC
cord-316996-8yimrpaz	41	24	is	be	VBZ
cord-316996-8yimrpaz	41	25	readily	readily	RB
cord-316996-8yimrpaz	41	26	destroyed	destroy	VBN
cord-316996-8yimrpaz	41	27	by	by	IN
cord-316996-8yimrpaz	41	28	enzymes	enzyme	NNS
cord-316996-8yimrpaz	41	29	known	know	VBN
cord-316996-8yimrpaz	41	30	as	as	IN
cord-316996-8yimrpaz	41	31	sialidases	sialidase	NNS
cord-316996-8yimrpaz	41	32	.	.	.
cord-316996-8yimrpaz	42	1	It	-PRON-	PRP
cord-316996-8yimrpaz	42	2	should	should	MD
cord-316996-8yimrpaz	42	3	be	be	VB
cord-316996-8yimrpaz	42	4	noted	note	VBN
cord-316996-8yimrpaz	42	5	that	that	IN
cord-316996-8yimrpaz	42	6	in	in	IN
cord-316996-8yimrpaz	42	7	solution	solution	NN
cord-316996-8yimrpaz	42	8	,	,	,
cord-316996-8yimrpaz	42	9	unbound	unbound	JJ
cord-316996-8yimrpaz	42	10	Sia	Sia	NNP
cord-316996-8yimrpaz	42	11	is	be	VBZ
cord-316996-8yimrpaz	42	12	mainly	mainly	RB
cord-316996-8yimrpaz	42	13	in	in	IN
cord-316996-8yimrpaz	42	14	the	the	DT
cord-316996-8yimrpaz	42	15	ß	ß	NN
cord-316996-8yimrpaz	42	16	-	-	HYPH
cord-316996-8yimrpaz	42	17	configuration	configuration	NN
cord-316996-8yimrpaz	42	18	,	,	,
cord-316996-8yimrpaz	42	19	with	with	IN
cord-316996-8yimrpaz	42	20	the	the	DT
cord-316996-8yimrpaz	42	21	C2	C2	NNP
cord-316996-8yimrpaz	42	22	hydroxyl	hydroxyl	NNS
cord-316996-8yimrpaz	42	23	positioned	position	VBN
cord-316996-8yimrpaz	42	24	axial	axial	JJ
cord-316996-8yimrpaz	42	25	to	to	IN
cord-316996-8yimrpaz	42	26	the	the	DT
cord-316996-8yimrpaz	42	27	ring	ring	NN
cord-316996-8yimrpaz	42	28	and	and	CC
cord-316996-8yimrpaz	42	29	in	in	IN
cord-316996-8yimrpaz	42	30	equilibrium	equilibrium	NN
cord-316996-8yimrpaz	42	31	with	with	IN
cord-316996-8yimrpaz	42	32	the	the	DT
cord-316996-8yimrpaz	42	33	minor	minor	JJ
cord-316996-8yimrpaz	42	34	a	a	DT
cord-316996-8yimrpaz	42	35	-	-	HYPH
cord-316996-8yimrpaz	42	36	form	form	NN
cord-316996-8yimrpaz	42	37	(	(	-LRB-
cord-316996-8yimrpaz	42	38	Vimr	Vimr	NNP
cord-316996-8yimrpaz	42	39	,	,	,
cord-316996-8yimrpaz	42	40	1994	1994	CD
cord-316996-8yimrpaz	42	41	)	)	-RRB-
cord-316996-8yimrpaz	42	42	.	.	.
cord-316996-8yimrpaz	43	1	The	the	DT
cord-316996-8yimrpaz	43	2	acidic	acidic	JJ
cord-316996-8yimrpaz	43	3	nature	nature	NN
cord-316996-8yimrpaz	43	4	of	of	IN
cord-316996-8yimrpaz	43	5	Sia	Sia	NNP
cord-316996-8yimrpaz	43	6	is	be	VBZ
cord-316996-8yimrpaz	43	7	due	due	JJ
cord-316996-8yimrpaz	43	8	to	to	IN
cord-316996-8yimrpaz	43	9	the	the	DT
cord-316996-8yimrpaz	43	10	carboxylate	carboxylate	NNP
cord-316996-8yimrpaz	43	11	at	at	IN
cord-316996-8yimrpaz	43	12	C	C	NNP
cord-316996-8yimrpaz	43	13	1	1	CD
cord-316996-8yimrpaz	43	14	,	,	,
cord-316996-8yimrpaz	43	15	which	which	WDT
cord-316996-8yimrpaz	43	16	is	be	VBZ
cord-316996-8yimrpaz	43	17	ionized	ionize	VBN
cord-316996-8yimrpaz	43	18	at	at	IN
cord-316996-8yimrpaz	43	19	physiological	physiological	JJ
cord-316996-8yimrpaz	43	20	pH	ph	NN
cord-316996-8yimrpaz	43	21	and	and	CC
cord-316996-8yimrpaz	43	22	has	have	VBZ
cord-316996-8yimrpaz	43	23	a	a	DT
cord-316996-8yimrpaz	43	24	pK	pK	NNP
cord-316996-8yimrpaz	43	25	of	of	IN
cord-316996-8yimrpaz	43	26	1.8	1.8	CD
cord-316996-8yimrpaz	43	27	-	-	SYM
cord-316996-8yimrpaz	43	28	2.6	2.6	CD
cord-316996-8yimrpaz	43	29	,	,	,
cord-316996-8yimrpaz	43	30	giving	give	VBG
cord-316996-8yimrpaz	43	31	the	the	DT
cord-316996-8yimrpaz	43	32	Sia	Sia	NNP
cord-316996-8yimrpaz	43	33	a	a	DT
cord-316996-8yimrpaz	43	34	number	number	NN
cord-316996-8yimrpaz	43	35	of	of	IN
cord-316996-8yimrpaz	43	36	useful	useful	JJ
cord-316996-8yimrpaz	43	37	features	feature	NNS
cord-316996-8yimrpaz	43	38	,	,	,
cord-316996-8yimrpaz	43	39	as	as	IN
cord-316996-8yimrpaz	43	40	highlighted	highlight	VBN
cord-316996-8yimrpaz	43	41	by	by	IN
cord-316996-8yimrpaz	43	42	Schauer	Schauer	NNP
cord-316996-8yimrpaz	43	43	(	(	-LRB-
cord-316996-8yimrpaz	43	44	Schauer	Schauer	NNP
cord-316996-8yimrpaz	43	45	,	,	,
cord-316996-8yimrpaz	43	46	Fig	Fig	NNP
cord-316996-8yimrpaz	43	47	.	.	NNP
cord-316996-8yimrpaz	43	48	1	1	CD
cord-316996-8yimrpaz	43	49	.	.	.
cord-316996-8yimrpaz	44	1	Structures	structure	NNS
cord-316996-8yimrpaz	44	2	of	of	IN
cord-316996-8yimrpaz	44	3	different	different	JJ
cord-316996-8yimrpaz	44	4	sialic	sialic	JJ
cord-316996-8yimrpaz	44	5	acid	acid	NN
cord-316996-8yimrpaz	44	6	derivatives	derivative	NNS
cord-316996-8yimrpaz	44	7	.	.	.
cord-316996-8yimrpaz	45	1	The	the	DT
cord-316996-8yimrpaz	45	2	numbering	numbering	NN
cord-316996-8yimrpaz	45	3	of	of	IN
cord-316996-8yimrpaz	45	4	carbons	carbon	NNS
cord-316996-8yimrpaz	45	5	is	be	VBZ
cord-316996-8yimrpaz	45	6	listed	list	VBN
cord-316996-8yimrpaz	45	7	in	in	IN
cord-316996-8yimrpaz	45	8	green	green	JJ
cord-316996-8yimrpaz	45	9	;	;	:
cord-316996-8yimrpaz	45	10	AcO	AcO	NNP
cord-316996-8yimrpaz	45	11	refers	refer	VBZ
cord-316996-8yimrpaz	45	12	to	to	IN
cord-316996-8yimrpaz	45	13	acetlylation	acetlylation	NN
cord-316996-8yimrpaz	45	14	.	.	.
cord-316996-8yimrpaz	46	1	Two	two	CD
cord-316996-8yimrpaz	46	2	common	common	JJ
cord-316996-8yimrpaz	46	3	linkages	linkage	NNS
cord-316996-8yimrpaz	46	4	of	of	IN
cord-316996-8yimrpaz	46	5	Sia	Sia	NNP
cord-316996-8yimrpaz	46	6	with	with	IN
cord-316996-8yimrpaz	46	7	galactose	galactose	NN
cord-316996-8yimrpaz	46	8	to	to	TO
cord-316996-8yimrpaz	46	9	form	form	VB
cord-316996-8yimrpaz	46	10	3	3	CD
cord-316996-8yimrpaz	46	11	0	0	CD
cord-316996-8yimrpaz	46	12	sialyllactose	sialyllactose	CD
cord-316996-8yimrpaz	46	13	(	(	-LRB-
cord-316996-8yimrpaz	46	14	Siaa2	Siaa2	NNP
cord-316996-8yimrpaz	46	15	-	-	HYPH
cord-316996-8yimrpaz	46	16	3Galß1	3galß1	CD
cord-316996-8yimrpaz	46	17	-	-	HYPH
cord-316996-8yimrpaz	46	18	4Glu	4glu	CD
cord-316996-8yimrpaz	46	19	)	)	-RRB-
cord-316996-8yimrpaz	46	20	and	and	CC
cord-316996-8yimrpaz	46	21	6	6	CD
cord-316996-8yimrpaz	46	22	0	0	CD
cord-316996-8yimrpaz	46	23	sialyllactose	sialyllactose	NN
cord-316996-8yimrpaz	46	24	(	(	-LRB-
cord-316996-8yimrpaz	47	1	Siaa2	Siaa2	NNP
cord-316996-8yimrpaz	47	2	-	-	HYPH
cord-316996-8yimrpaz	47	3	6Galß1	6galß1	CD
cord-316996-8yimrpaz	47	4	-	-	HYPH
cord-316996-8yimrpaz	47	5	4Glu	4glu	CD
cord-316996-8yimrpaz	47	6	)	)	-RRB-
cord-316996-8yimrpaz	47	7	are	be	VBP
cord-316996-8yimrpaz	47	8	shown	show	VBN
cord-316996-8yimrpaz	47	9	.	.	.
cord-316996-8yimrpaz	48	1	2000	2000	CD
cord-316996-8yimrpaz	48	2	)	)	-RRB-
cord-316996-8yimrpaz	49	1	and	and	CC
cord-316996-8yimrpaz	49	2	Vimr	Vimr	NNP
cord-316996-8yimrpaz	49	3	(	(	-LRB-
cord-316996-8yimrpaz	49	4	Vimr	Vimr	NNP
cord-316996-8yimrpaz	49	5	et	et	FW
cord-316996-8yimrpaz	49	6	al	al	NNP
cord-316996-8yimrpaz	49	7	.	.	NNP
cord-316996-8yimrpaz	49	8	,	,	,
cord-316996-8yimrpaz	49	9	2004	2004	CD
cord-316996-8yimrpaz	49	10	)	)	-RRB-
cord-316996-8yimrpaz	49	11	.	.	.
cord-316996-8yimrpaz	50	1	The	the	DT
cord-316996-8yimrpaz	50	2	negatively	negatively	RB
cord-316996-8yimrpaz	50	3	-	-	HYPH
cord-316996-8yimrpaz	50	4	charged	charge	VBN
cord-316996-8yimrpaz	50	5	glycoproteins	glycoprotein	NNS
cord-316996-8yimrpaz	50	6	will	will	MD
cord-316996-8yimrpaz	50	7	mutually	mutually	RB
cord-316996-8yimrpaz	50	8	repel	repel	VB
cord-316996-8yimrpaz	50	9	each	each	DT
cord-316996-8yimrpaz	50	10	other	other	JJ
cord-316996-8yimrpaz	50	11	,	,	,
cord-316996-8yimrpaz	50	12	allowing	allow	VBG
cord-316996-8yimrpaz	50	13	trapping	trapping	NN
cord-316996-8yimrpaz	50	14	of	of	IN
cord-316996-8yimrpaz	50	15	water	water	NN
cord-316996-8yimrpaz	50	16	molecules	molecule	NNS
cord-316996-8yimrpaz	50	17	to	to	TO
cord-316996-8yimrpaz	50	18	produce	produce	VB
cord-316996-8yimrpaz	50	19	a	a	DT
cord-316996-8yimrpaz	50	20	highly	highly	RB
cord-316996-8yimrpaz	50	21	viscous	viscous	JJ
cord-316996-8yimrpaz	50	22	aqueous	aqueous	JJ
cord-316996-8yimrpaz	50	23	solution	solution	NN
cord-316996-8yimrpaz	50	24	that	that	WDT
cord-316996-8yimrpaz	50	25	comprises	comprise	VBZ
cord-316996-8yimrpaz	50	26	the	the	DT
cord-316996-8yimrpaz	50	27	glycocalyx	glycocalyx	NN
cord-316996-8yimrpaz	50	28	of	of	IN
cord-316996-8yimrpaz	50	29	many	many	JJ
cord-316996-8yimrpaz	50	30	epithelial	epithelial	JJ
cord-316996-8yimrpaz	50	31	surfaces	surface	NNS
cord-316996-8yimrpaz	50	32	.	.	.
cord-316996-8yimrpaz	51	1	The	the	DT
cord-316996-8yimrpaz	51	2	importance	importance	NN
cord-316996-8yimrpaz	51	3	of	of	IN
cord-316996-8yimrpaz	51	4	this	this	DT
cord-316996-8yimrpaz	51	5	shield	shield	NN
cord-316996-8yimrpaz	51	6	was	be	VBD
cord-316996-8yimrpaz	51	7	highlighted	highlight	VBN
cord-316996-8yimrpaz	51	8	by	by	IN
cord-316996-8yimrpaz	51	9	Varki	Varki	NNP
cord-316996-8yimrpaz	51	10	and	and	CC
cord-316996-8yimrpaz	51	11	Varki	Varki	NNP
cord-316996-8yimrpaz	51	12	,	,	,
cord-316996-8yimrpaz	51	13	who	who	WP
cord-316996-8yimrpaz	51	14	indicated	indicate	VBD
cord-316996-8yimrpaz	51	15	that	that	IN
cord-316996-8yimrpaz	51	16	>	>	XX
cord-316996-8yimrpaz	51	17	1	1	CD
cord-316996-8yimrpaz	51	18	%	%	NN
cord-316996-8yimrpaz	51	19	of	of	IN
cord-316996-8yimrpaz	51	20	the	the	DT
cord-316996-8yimrpaz	51	21	mammalian	mammalian	JJ
cord-316996-8yimrpaz	51	22	genome	genome	NN
cord-316996-8yimrpaz	51	23	encodes	encode	VBZ
cord-316996-8yimrpaz	51	24	proteins	protein	NNS
cord-316996-8yimrpaz	51	25	involved	involve	VBN
cord-316996-8yimrpaz	51	26	in	in	IN
cord-316996-8yimrpaz	51	27	this	this	DT
cord-316996-8yimrpaz	51	28	glycosylation	glycosylation	NN
cord-316996-8yimrpaz	51	29	pathway	pathway	NN
cord-316996-8yimrpaz	51	30	(	(	-LRB-
cord-316996-8yimrpaz	52	1	Lehmann	Lehmann	NNP
cord-316996-8yimrpaz	52	2	et	et	NNP
cord-316996-8yimrpaz	52	3	al	al	NNP
cord-316996-8yimrpaz	52	4	.	.	.
cord-316996-8yimrpaz	53	1	,	,	,
cord-316996-8yimrpaz	53	2	2006	2006	CD
cord-316996-8yimrpaz	53	3	;	;	:
cord-316996-8yimrpaz	53	4	Varki	Varki	NNP
cord-316996-8yimrpaz	53	5	and	and	CC
cord-316996-8yimrpaz	53	6	Varki	Varki	NNP
cord-316996-8yimrpaz	53	7	,	,	,
cord-316996-8yimrpaz	53	8	2007	2007	CD
cord-316996-8yimrpaz	53	9	)	)	-RRB-
cord-316996-8yimrpaz	53	10	.	.	.
cord-316996-8yimrpaz	54	1	The	the	DT
cord-316996-8yimrpaz	54	2	high	high	JJ
cord-316996-8yimrpaz	54	3	Sia	Sia	NNP
cord-316996-8yimrpaz	54	4	content	content	NN
cord-316996-8yimrpaz	54	5	of	of	IN
cord-316996-8yimrpaz	54	6	mucin	mucin	NN
cord-316996-8yimrpaz	54	7	acts	act	NNS
cord-316996-8yimrpaz	54	8	as	as	IN
cord-316996-8yimrpaz	54	9	a	a	DT
cord-316996-8yimrpaz	54	10	lubricant	lubricant	NN
cord-316996-8yimrpaz	54	11	for	for	IN
cord-316996-8yimrpaz	54	12	epithelial	epithelial	JJ
cord-316996-8yimrpaz	54	13	surfaces	surface	NNS
cord-316996-8yimrpaz	54	14	in	in	IN
cord-316996-8yimrpaz	54	15	the	the	DT
cord-316996-8yimrpaz	54	16	cornea	cornea	NN
cord-316996-8yimrpaz	54	17	,	,	,
cord-316996-8yimrpaz	54	18	nasal	nasal	NN
cord-316996-8yimrpaz	54	19	mucosa	mucosa	JJ
cord-316996-8yimrpaz	54	20	,	,	,
cord-316996-8yimrpaz	54	21	respiratory	respiratory	JJ
cord-316996-8yimrpaz	54	22	and	and	CC
cord-316996-8yimrpaz	54	23	gastrointestinal	gastrointestinal	JJ
cord-316996-8yimrpaz	54	24	tracts	tract	NNS
cord-316996-8yimrpaz	54	25	and	and	CC
cord-316996-8yimrpaz	54	26	other	other	JJ
cord-316996-8yimrpaz	54	27	tissues	tissue	NNS
cord-316996-8yimrpaz	54	28	in	in	IN
cord-316996-8yimrpaz	54	29	contact	contact	NN
cord-316996-8yimrpaz	54	30	with	with	IN
cord-316996-8yimrpaz	54	31	the	the	DT
cord-316996-8yimrpaz	54	32	environment	environment	NN
cord-316996-8yimrpaz	54	33	.	.	.
cord-316996-8yimrpaz	55	1	This	this	DT
cord-316996-8yimrpaz	55	2	mucin	mucin	NN
cord-316996-8yimrpaz	55	3	protects	protect	VBZ
cord-316996-8yimrpaz	55	4	the	the	DT
cord-316996-8yimrpaz	55	5	cells	cell	NNS
cord-316996-8yimrpaz	55	6	against	against	IN
cord-316996-8yimrpaz	55	7	mechanical	mechanical	JJ
cord-316996-8yimrpaz	55	8	and	and	CC
cord-316996-8yimrpaz	55	9	chemical	chemical	JJ
cord-316996-8yimrpaz	55	10	damage	damage	NN
cord-316996-8yimrpaz	55	11	,	,	,
cord-316996-8yimrpaz	55	12	such	such	JJ
cord-316996-8yimrpaz	55	13	as	as	IN
cord-316996-8yimrpaz	55	14	gastric	gastric	JJ
cord-316996-8yimrpaz	55	15	acid	acid	NN
cord-316996-8yimrpaz	55	16	and	and	CC
cord-316996-8yimrpaz	55	17	digestive	digestive	JJ
cord-316996-8yimrpaz	55	18	enzymes	enzyme	NNS
cord-316996-8yimrpaz	55	19	.	.	.
cord-316996-8yimrpaz	56	1	The	the	DT
cord-316996-8yimrpaz	56	2	Sia	Sia	NNP
cord-316996-8yimrpaz	56	3	content	content	NN
cord-316996-8yimrpaz	56	4	of	of	IN
cord-316996-8yimrpaz	56	5	mucin	mucin	NN
cord-316996-8yimrpaz	56	6	also	also	RB
cord-316996-8yimrpaz	56	7	functions	function	VBZ
cord-316996-8yimrpaz	56	8	as	as	IN
cord-316996-8yimrpaz	56	9	a	a	DT
cord-316996-8yimrpaz	56	10	decoy	decoy	NN
cord-316996-8yimrpaz	56	11	for	for	IN
cord-316996-8yimrpaz	56	12	pathogens	pathogen	NNS
cord-316996-8yimrpaz	56	13	that	that	WDT
cord-316996-8yimrpaz	56	14	bind	bind	VBP
cord-316996-8yimrpaz	56	15	to	to	IN
cord-316996-8yimrpaz	56	16	Sia	Sia	NNP
cord-316996-8yimrpaz	56	17	,	,	,
cord-316996-8yimrpaz	56	18	such	such	JJ
cord-316996-8yimrpaz	56	19	as	as	IN
cord-316996-8yimrpaz	56	20	respiratory	respiratory	JJ
cord-316996-8yimrpaz	56	21	viruses	virus	NNS
cord-316996-8yimrpaz	56	22	(	(	-LRB-
cord-316996-8yimrpaz	56	23	Lehmann	Lehmann	NNP
cord-316996-8yimrpaz	56	24	et	et	NNP
cord-316996-8yimrpaz	56	25	al	al	NNP
cord-316996-8yimrpaz	56	26	.	.	NNP
cord-316996-8yimrpaz	56	27	,	,	,
cord-316996-8yimrpaz	56	28	2006	2006	CD
cord-316996-8yimrpaz	56	29	)	)	-RRB-
cord-316996-8yimrpaz	56	30	.	.	.
cord-316996-8yimrpaz	57	1	The	the	DT
cord-316996-8yimrpaz	57	2	mucin	mucin	NN
cord-316996-8yimrpaz	57	3	is	be	VBZ
cord-316996-8yimrpaz	57	4	produced	produce	VBN
cord-316996-8yimrpaz	57	5	by	by	IN
cord-316996-8yimrpaz	57	6	goblet	goblet	NN
cord-316996-8yimrpaz	57	7	cells	cell	NNS
cord-316996-8yimrpaz	57	8	and	and	CC
cord-316996-8yimrpaz	57	9	normally	normally	RB
cord-316996-8yimrpaz	57	10	is	be	VBZ
cord-316996-8yimrpaz	57	11	a	a	DT
cord-316996-8yimrpaz	57	12	benefit	benefit	NN
cord-316996-8yimrpaz	57	13	to	to	IN
cord-316996-8yimrpaz	57	14	the	the	DT
cord-316996-8yimrpaz	57	15	host	host	NN
cord-316996-8yimrpaz	58	1	(	(	-LRB-
cord-316996-8yimrpaz	58	2	Nicholls	Nicholls	NNP
cord-316996-8yimrpaz	58	3	et	et	NNP
cord-316996-8yimrpaz	58	4	al	al	NNP
cord-316996-8yimrpaz	58	5	.	.	NNP
cord-316996-8yimrpaz	58	6	,	,	,
cord-316996-8yimrpaz	58	7	2007	2007	CD
cord-316996-8yimrpaz	58	8	)	)	-RRB-
cord-316996-8yimrpaz	58	9	.	.	.
cord-316996-8yimrpaz	59	1	However	however	RB
cord-316996-8yimrpaz	59	2	,	,	,
cord-316996-8yimrpaz	59	3	in	in	IN
cord-316996-8yimrpaz	59	4	certain	certain	JJ
cord-316996-8yimrpaz	59	5	diseases	disease	NNS
cord-316996-8yimrpaz	59	6	such	such	JJ
cord-316996-8yimrpaz	59	7	as	as	IN
cord-316996-8yimrpaz	59	8	cystic	cystic	JJ
cord-316996-8yimrpaz	59	9	fibrosis	fibrosis	NN
cord-316996-8yimrpaz	59	10	,	,	,
cord-316996-8yimrpaz	59	11	changes	change	NNS
cord-316996-8yimrpaz	59	12	in	in	IN
cord-316996-8yimrpaz	59	13	mucin	mucin	NN
cord-316996-8yimrpaz	59	14	composition	composition	NN
cord-316996-8yimrpaz	59	15	allow	allow	VBP
cord-316996-8yimrpaz	59	16	increased	increase	VBN
cord-316996-8yimrpaz	59	17	bacterial	bacterial	JJ
cord-316996-8yimrpaz	59	18	growth	growth	NN
cord-316996-8yimrpaz	59	19	and	and	CC
cord-316996-8yimrpaz	59	20	pathogenesis	pathogenesis	NN
cord-316996-8yimrpaz	60	1	(	(	-LRB-
cord-316996-8yimrpaz	60	2	Xia	Xia	NNP
cord-316996-8yimrpaz	60	3	et	et	NNP
cord-316996-8yimrpaz	60	4	al	al	NNP
cord-316996-8yimrpaz	60	5	.	.	NNP
cord-316996-8yimrpaz	60	6	,	,	,
cord-316996-8yimrpaz	60	7	2005	2005	CD
cord-316996-8yimrpaz	60	8	)	)	-RRB-
cord-316996-8yimrpaz	60	9	.	.	.
cord-316996-8yimrpaz	61	1	The	the	DT
cord-316996-8yimrpaz	61	2	second	second	JJ
cord-316996-8yimrpaz	61	3	main	main	JJ
cord-316996-8yimrpaz	61	4	function	function	NN
cord-316996-8yimrpaz	61	5	of	of	IN
cord-316996-8yimrpaz	61	6	Sia	Sia	NNP
cord-316996-8yimrpaz	61	7	is	be	VBZ
cord-316996-8yimrpaz	61	8	to	to	TO
cord-316996-8yimrpaz	61	9	enable	enable	VB
cord-316996-8yimrpaz	61	10	host	host	NN
cord-316996-8yimrpaz	61	11	proteins	protein	NNS
cord-316996-8yimrpaz	61	12	avoid	avoid	VBP
cord-316996-8yimrpaz	61	13	and	and	CC
cord-316996-8yimrpaz	61	14	evade	evade	VB
cord-316996-8yimrpaz	61	15	recognition	recognition	NN
cord-316996-8yimrpaz	61	16	by	by	IN
cord-316996-8yimrpaz	61	17	the	the	DT
cord-316996-8yimrpaz	61	18	body	body	NN
cord-316996-8yimrpaz	61	19	's	's	POS
cord-316996-8yimrpaz	61	20	defense	defense	NN
cord-316996-8yimrpaz	61	21	mechanisms	mechanism	NNS
cord-316996-8yimrpaz	61	22	.	.	.
cord-316996-8yimrpaz	62	1	The	the	DT
cord-316996-8yimrpaz	62	2	capping	capping	NN
cord-316996-8yimrpaz	62	3	of	of	IN
cord-316996-8yimrpaz	62	4	terminal	terminal	JJ
cord-316996-8yimrpaz	62	5	galactose	galactose	NN
cord-316996-8yimrpaz	62	6	by	by	IN
cord-316996-8yimrpaz	62	7	Sia	Sia	NNP
cord-316996-8yimrpaz	62	8	masks	mask	NNS
cord-316996-8yimrpaz	62	9	the	the	DT
cord-316996-8yimrpaz	62	10	recognition	recognition	NN
cord-316996-8yimrpaz	62	11	of	of	IN
cord-316996-8yimrpaz	62	12	certain	certain	JJ
cord-316996-8yimrpaz	62	13	oligosaccharides	oligosaccharide	NNS
cord-316996-8yimrpaz	62	14	by	by	IN
cord-316996-8yimrpaz	62	15	the	the	DT
cord-316996-8yimrpaz	62	16	asialoglycoprotein	asialoglycoprotein	NNP
cord-316996-8yimrpaz	62	17	receptor	receptor	NN
cord-316996-8yimrpaz	62	18	of	of	IN
cord-316996-8yimrpaz	62	19	the	the	DT
cord-316996-8yimrpaz	62	20	liver	liver	NN
cord-316996-8yimrpaz	62	21	(	(	-LRB-
cord-316996-8yimrpaz	62	22	Grewal	Grewal	NNP
cord-316996-8yimrpaz	62	23	et	et	NNP
cord-316996-8yimrpaz	62	24	al	al	NNP
cord-316996-8yimrpaz	62	25	.	.	NNP
cord-316996-8yimrpaz	62	26	,	,	,
cord-316996-8yimrpaz	62	27	2008	2008	CD
cord-316996-8yimrpaz	62	28	)	)	-RRB-
cord-316996-8yimrpaz	62	29	or	or	CC
cord-316996-8yimrpaz	62	30	similar	similar	JJ
cord-316996-8yimrpaz	62	31	receptors	receptor	NNS
cord-316996-8yimrpaz	62	32	present	present	JJ
cord-316996-8yimrpaz	62	33	on	on	IN
cord-316996-8yimrpaz	62	34	macrophages	macrophage	NNS
cord-316996-8yimrpaz	62	35	.	.	.
cord-316996-8yimrpaz	63	1	The	the	DT
cord-316996-8yimrpaz	63	2	sialylation	sialylation	NN
cord-316996-8yimrpaz	63	3	of	of	IN
cord-316996-8yimrpaz	63	4	compounds	compound	NNS
cord-316996-8yimrpaz	63	5	allows	allow	VBZ
cord-316996-8yimrpaz	63	6	plasma	plasma	NN
cord-316996-8yimrpaz	63	7	macromolecules	macromolecule	NNS
cord-316996-8yimrpaz	63	8	to	to	TO
cord-316996-8yimrpaz	63	9	have	have	VB
cord-316996-8yimrpaz	63	10	a	a	DT
cord-316996-8yimrpaz	63	11	longer	long	JJR
cord-316996-8yimrpaz	63	12	period	period	NN
cord-316996-8yimrpaz	63	13	of	of	IN
cord-316996-8yimrpaz	63	14	time	time	NN
cord-316996-8yimrpaz	63	15	in	in	IN
cord-316996-8yimrpaz	63	16	the	the	DT
cord-316996-8yimrpaz	63	17	circulation	circulation	NN
cord-316996-8yimrpaz	63	18	;	;	:
cord-316996-8yimrpaz	63	19	the	the	DT
cord-316996-8yimrpaz	63	20	number	number	NN
cord-316996-8yimrpaz	63	21	of	of	IN
cord-316996-8yimrpaz	63	22	glycosylation	glycosylation	NN
cord-316996-8yimrpaz	63	23	sites	site	NNS
cord-316996-8yimrpaz	63	24	is	be	VBZ
cord-316996-8yimrpaz	63	25	related	relate	VBN
cord-316996-8yimrpaz	63	26	to	to	IN
cord-316996-8yimrpaz	63	27	biological	biological	JJ
cord-316996-8yimrpaz	63	28	functions	function	NNS
cord-316996-8yimrpaz	63	29	(	(	-LRB-
cord-316996-8yimrpaz	63	30	Banks	bank	NNS
cord-316996-8yimrpaz	63	31	,	,	,
cord-316996-8yimrpaz	63	32	2011	2011	CD
cord-316996-8yimrpaz	63	33	;	;	:
cord-316996-8yimrpaz	63	34	Sun	Sun	NNP
cord-316996-8yimrpaz	63	35	et	et	NNP
cord-316996-8yimrpaz	63	36	al	al	NNP
cord-316996-8yimrpaz	63	37	.	.	NNP
cord-316996-8yimrpaz	63	38	,	,	,
cord-316996-8yimrpaz	63	39	2011	2011	CD
cord-316996-8yimrpaz	63	40	)	)	-RRB-
cord-316996-8yimrpaz	63	41	.	.	.
cord-316996-8yimrpaz	64	1	Conversely	conversely	RB
cord-316996-8yimrpaz	64	2	,	,	,
cord-316996-8yimrpaz	64	3	the	the	DT
cord-316996-8yimrpaz	64	4	half	half	JJ
cord-316996-8yimrpaz	64	5	-	-	HYPH
cord-316996-8yimrpaz	64	6	life	life	NN
cord-316996-8yimrpaz	64	7	of	of	IN
cord-316996-8yimrpaz	64	8	many	many	JJ
cord-316996-8yimrpaz	64	9	serum	serum	NN
cord-316996-8yimrpaz	64	10	glycoproteins	glycoprotein	NNS
cord-316996-8yimrpaz	64	11	such	such	JJ
cord-316996-8yimrpaz	64	12	as	as	IN
cord-316996-8yimrpaz	64	13	thyrotropin	thyrotropin	NN
cord-316996-8yimrpaz	64	14	,	,	,
cord-316996-8yimrpaz	64	15	erythropoietin	erythropoietin	NN
cord-316996-8yimrpaz	64	16	,	,	,
cord-316996-8yimrpaz	64	17	and	and	CC
cord-316996-8yimrpaz	64	18	follicle	follicle	NN
cord-316996-8yimrpaz	64	19	stimulating	stimulate	VBG
cord-316996-8yimrpaz	64	20	hormone	hormone	NN
cord-316996-8yimrpaz	64	21	is	be	VBZ
cord-316996-8yimrpaz	64	22	decreased	decrease	VBN
cord-316996-8yimrpaz	64	23	upon	upon	IN
cord-316996-8yimrpaz	64	24	desialylation	desialylation	NN
cord-316996-8yimrpaz	64	25	.	.	.
cord-316996-8yimrpaz	65	1	Glycosylation	glycosylation	NN
cord-316996-8yimrpaz	65	2	of	of	IN
cord-316996-8yimrpaz	65	3	proteins	protein	NNS
cord-316996-8yimrpaz	65	4	as	as	IN
cord-316996-8yimrpaz	65	5	a	a	DT
cord-316996-8yimrpaz	65	6	shield	shield	NN
cord-316996-8yimrpaz	65	7	to	to	TO
cord-316996-8yimrpaz	65	8	prevent	prevent	VB
cord-316996-8yimrpaz	65	9	recognition	recognition	NN
cord-316996-8yimrpaz	65	10	is	be	VBZ
cord-316996-8yimrpaz	65	11	not	not	RB
cord-316996-8yimrpaz	65	12	limited	limit	VBN
cord-316996-8yimrpaz	65	13	to	to	IN
cord-316996-8yimrpaz	65	14	host	host	NN
cord-316996-8yimrpaz	65	15	factors	factor	NNS
cord-316996-8yimrpaz	65	16	,	,	,
cord-316996-8yimrpaz	65	17	but	but	CC
cord-316996-8yimrpaz	65	18	is	be	VBZ
cord-316996-8yimrpaz	65	19	also	also	RB
cord-316996-8yimrpaz	65	20	employed	employ	VBN
cord-316996-8yimrpaz	65	21	by	by	IN
cord-316996-8yimrpaz	65	22	pathogens	pathogen	NNS
cord-316996-8yimrpaz	65	23	such	such	JJ
cord-316996-8yimrpaz	65	24	as	as	IN
cord-316996-8yimrpaz	65	25	the	the	DT
cord-316996-8yimrpaz	65	26	influenza	influenza	NN
cord-316996-8yimrpaz	65	27	viruses	virus	NNS
cord-316996-8yimrpaz	65	28	,	,	,
cord-316996-8yimrpaz	65	29	leading	lead	VBG
cord-316996-8yimrpaz	65	30	to	to	IN
cord-316996-8yimrpaz	65	31	the	the	DT
cord-316996-8yimrpaz	65	32	development	development	NN
cord-316996-8yimrpaz	65	33	of	of	IN
cord-316996-8yimrpaz	65	34	antigenic	antigenic	JJ
cord-316996-8yimrpaz	65	35	variation	variation	NN
cord-316996-8yimrpaz	66	1	(	(	-LRB-
cord-316996-8yimrpaz	66	2	Sun	Sun	NNP
cord-316996-8yimrpaz	66	3	et	et	FW
cord-316996-8yimrpaz	66	4	al	al	NNP
cord-316996-8yimrpaz	66	5	.	.	.
cord-316996-8yimrpaz	67	1	,	,	,
cord-316996-8yimrpaz	67	2	2011	2011	CD
cord-316996-8yimrpaz	67	3	)	)	-RRB-
cord-316996-8yimrpaz	67	4	.	.	.
cord-316996-8yimrpaz	68	1	Finally	finally	RB
cord-316996-8yimrpaz	68	2	,	,	,
cord-316996-8yimrpaz	68	3	the	the	DT
cord-316996-8yimrpaz	68	4	presence	presence	NN
cord-316996-8yimrpaz	68	5	of	of	IN
cord-316996-8yimrpaz	68	6	Sia	Sia	NNP
cord-316996-8yimrpaz	68	7	on	on	IN
cord-316996-8yimrpaz	68	8	glycans	glycan	NNS
cord-316996-8yimrpaz	68	9	may	may	MD
cord-316996-8yimrpaz	68	10	also	also	RB
cord-316996-8yimrpaz	68	11	modulate	modulate	VB
cord-316996-8yimrpaz	68	12	the	the	DT
cord-316996-8yimrpaz	68	13	immune	immune	JJ
cord-316996-8yimrpaz	68	14	response	response	NN
cord-316996-8yimrpaz	68	15	,	,	,
cord-316996-8yimrpaz	68	16	through	through	IN
cord-316996-8yimrpaz	68	17	recognition	recognition	NN
cord-316996-8yimrpaz	68	18	by	by	IN
cord-316996-8yimrpaz	68	19	Sia	Sia	NNP
cord-316996-8yimrpaz	68	20	-	-	HYPH
cord-316996-8yimrpaz	68	21	binding	bind	VBG
cord-316996-8yimrpaz	68	22	lectins	lectin	NNS
cord-316996-8yimrpaz	68	23	,	,	,
cord-316996-8yimrpaz	68	24	now	now	RB
cord-316996-8yimrpaz	68	25	known	know	VBN
cord-316996-8yimrpaz	68	26	as	as	IN
cord-316996-8yimrpaz	68	27	Siglecs	Siglecs	NNP
cord-316996-8yimrpaz	68	28	.	.	.
cord-316996-8yimrpaz	69	1	The	the	DT
cord-316996-8yimrpaz	69	2	first	first	JJ
cord-316996-8yimrpaz	69	3	Siglec	Siglec	NNP
cord-316996-8yimrpaz	69	4	to	to	TO
cord-316996-8yimrpaz	69	5	be	be	VB
cord-316996-8yimrpaz	69	6	identified	identify	VBN
cord-316996-8yimrpaz	69	7	,	,	,
cord-316996-8yimrpaz	69	8	sialoadhesin	sialoadhesin	NNP
cord-316996-8yimrpaz	69	9	,	,	,
cord-316996-8yimrpaz	69	10	was	be	VBD
cord-316996-8yimrpaz	69	11	found	find	VBN
cord-316996-8yimrpaz	69	12	on	on	IN
cord-316996-8yimrpaz	69	13	macrophages	macrophage	NNS
cord-316996-8yimrpaz	69	14	(	(	-LRB-
cord-316996-8yimrpaz	69	15	O'Neill	O'Neill	NNP
cord-316996-8yimrpaz	69	16	et	et	NNP
cord-316996-8yimrpaz	69	17	al	al	NNP
cord-316996-8yimrpaz	69	18	.	.	NNP
cord-316996-8yimrpaz	69	19	,	,	,
cord-316996-8yimrpaz	69	20	2013	2013	CD
cord-316996-8yimrpaz	69	21	)	)	-RRB-
cord-316996-8yimrpaz	69	22	,	,	,
cord-316996-8yimrpaz	69	23	but	but	CC
cord-316996-8yimrpaz	69	24	more	more	JJR
cord-316996-8yimrpaz	69	25	than	than	IN
cord-316996-8yimrpaz	69	26	10	10	CD
cord-316996-8yimrpaz	69	27	different	different	JJ
cord-316996-8yimrpaz	69	28	Siglec	Siglec	NNP
cord-316996-8yimrpaz	69	29	molecules	molecule	NNS
cord-316996-8yimrpaz	69	30	have	have	VBP
cord-316996-8yimrpaz	69	31	since	since	IN
cord-316996-8yimrpaz	69	32	been	be	VBN
cord-316996-8yimrpaz	69	33	discovered	discover	VBN
cord-316996-8yimrpaz	69	34	(	(	-LRB-
cord-316996-8yimrpaz	69	35	reviewed	review	VBN
cord-316996-8yimrpaz	69	36	in	in	IN
cord-316996-8yimrpaz	69	37	Varki	Varki	NNP
cord-316996-8yimrpaz	69	38	and	and	CC
cord-316996-8yimrpaz	69	39	Gagneux	Gagneux	NNP
cord-316996-8yimrpaz	69	40	(	(	-LRB-
cord-316996-8yimrpaz	69	41	2012	2012	CD
cord-316996-8yimrpaz	69	42	)	)	-RRB-
cord-316996-8yimrpaz	69	43	)	)	-RRB-
cord-316996-8yimrpaz	69	44	.	.	.
cord-316996-8yimrpaz	70	1	As	as	IN
cord-316996-8yimrpaz	70	2	mentioned	mention	VBN
cord-316996-8yimrpaz	70	3	previously	previously	RB
cord-316996-8yimrpaz	70	4	,	,	,
cord-316996-8yimrpaz	70	5	Sia	Sia	NNP
cord-316996-8yimrpaz	70	6	can	can	MD
cord-316996-8yimrpaz	70	7	undergo	undergo	VB
cord-316996-8yimrpaz	70	8	modification	modification	NN
cord-316996-8yimrpaz	70	9	,	,	,
cord-316996-8yimrpaz	70	10	and	and	CC
cord-316996-8yimrpaz	70	11	the	the	DT
cord-316996-8yimrpaz	70	12	two	two	CD
cord-316996-8yimrpaz	70	13	most	most	RBS
cord-316996-8yimrpaz	70	14	common	common	JJ
cord-316996-8yimrpaz	70	15	changes	change	NNS
cord-316996-8yimrpaz	70	16	are	be	VBP
cord-316996-8yimrpaz	70	17	acetylation	acetylation	NN
cord-316996-8yimrpaz	70	18	and	and	CC
cord-316996-8yimrpaz	70	19	hydroxylation	hydroxylation	NN
cord-316996-8yimrpaz	70	20	to	to	IN
cord-316996-8yimrpaz	70	21	glycolylneuraminic	glycolylneuraminic	NN
cord-316996-8yimrpaz	70	22	acid	acid	NNP
cord-316996-8yimrpaz	70	23	(	(	-LRB-
cord-316996-8yimrpaz	70	24	Neu5Gc	Neu5Gc	NNP
cord-316996-8yimrpaz	70	25	)	)	-RRB-
cord-316996-8yimrpaz	70	26	,	,	,
cord-316996-8yimrpaz	70	27	a	a	DT
cord-316996-8yimrpaz	70	28	variant	variant	JJ
cord-316996-8yimrpaz	70	29	present	present	NN
cord-316996-8yimrpaz	70	30	in	in	IN
cord-316996-8yimrpaz	70	31	many	many	JJ
cord-316996-8yimrpaz	70	32	animal	animal	NN
cord-316996-8yimrpaz	70	33	species	specie	NNS
cord-316996-8yimrpaz	70	34	but	but	CC
cord-316996-8yimrpaz	70	35	not	not	RB
cord-316996-8yimrpaz	70	36	in	in	IN
cord-316996-8yimrpaz	70	37	humans	human	NNS
cord-316996-8yimrpaz	70	38	.	.	.
cord-316996-8yimrpaz	71	1	In	in	IN
cord-316996-8yimrpaz	71	2	the	the	DT
cord-316996-8yimrpaz	71	3	former	former	JJ
cord-316996-8yimrpaz	71	4	situation	situation	NN
cord-316996-8yimrpaz	71	5	,	,	,
cord-316996-8yimrpaz	71	6	this	this	DT
cord-316996-8yimrpaz	71	7	occurs	occur	VBZ
cord-316996-8yimrpaz	71	8	at	at	IN
cord-316996-8yimrpaz	71	9	C4	C4	NNP
cord-316996-8yimrpaz	71	10	and	and	CC
cord-316996-8yimrpaz	71	11	C6	C6	NNP
cord-316996-8yimrpaz	71	12	-	-	HYPH
cord-316996-8yimrpaz	71	13	9	9	CD
cord-316996-8yimrpaz	72	1	(	(	-LRB-
cord-316996-8yimrpaz	72	2	Cao	Cao	NNP
cord-316996-8yimrpaz	72	3	et	et	NNP
cord-316996-8yimrpaz	72	4	al	al	NNP
cord-316996-8yimrpaz	72	5	.	.	NNP
cord-316996-8yimrpaz	72	6	,	,	,
cord-316996-8yimrpaz	72	7	2009	2009	CD
cord-316996-8yimrpaz	72	8	;	;	:
cord-316996-8yimrpaz	72	9	Schauer	Schauer	NNP
cord-316996-8yimrpaz	72	10	et	et	NNP
cord-316996-8yimrpaz	72	11	al	al	NNP
cord-316996-8yimrpaz	72	12	.	.	NNP
cord-316996-8yimrpaz	72	13	,	,	,
cord-316996-8yimrpaz	72	14	2011	2011	CD
cord-316996-8yimrpaz	72	15	)	)	-RRB-
cord-316996-8yimrpaz	72	16	with	with	IN
cord-316996-8yimrpaz	72	17	identification	identification	NN
cord-316996-8yimrpaz	72	18	of	of	IN
cord-316996-8yimrpaz	72	19	the	the	DT
cord-316996-8yimrpaz	72	20	enzyme	enzyme	NN
cord-316996-8yimrpaz	72	21	sialate	sialate	NN
cord-316996-8yimrpaz	72	22	-	-	HYPH
cord-316996-8yimrpaz	72	23	O	o	NN
cord-316996-8yimrpaz	72	24	-	-	HYPH
cord-316996-8yimrpaz	72	25	acetyltransferase	acetyltransferase	NN
cord-316996-8yimrpaz	72	26	as	as	IN
cord-316996-8yimrpaz	72	27	a	a	DT
cord-316996-8yimrpaz	72	28	candidate	candidate	NN
cord-316996-8yimrpaz	72	29	recently	recently	RB
cord-316996-8yimrpaz	72	30	identified	identify	VBD
cord-316996-8yimrpaz	72	31	(	(	-LRB-
cord-316996-8yimrpaz	72	32	Arming	arming	FW
cord-316996-8yimrpaz	72	33	et	et	FW
cord-316996-8yimrpaz	72	34	al	al	NNP
cord-316996-8yimrpaz	72	35	.	.	NNP
cord-316996-8yimrpaz	72	36	,	,	,
cord-316996-8yimrpaz	72	37	2011	2011	CD
cord-316996-8yimrpaz	72	38	)	)	-RRB-
cord-316996-8yimrpaz	72	39	.	.	.
cord-316996-8yimrpaz	73	1	Modifications	modification	NNS
cord-316996-8yimrpaz	73	2	of	of	IN
cord-316996-8yimrpaz	73	3	Sia	Sia	NNP
cord-316996-8yimrpaz	73	4	are	be	VBP
cord-316996-8yimrpaz	73	5	important	important	JJ
cord-316996-8yimrpaz	73	6	to	to	TO
cord-316996-8yimrpaz	73	7	consider	consider	VB
cord-316996-8yimrpaz	73	8	,	,	,
cord-316996-8yimrpaz	73	9	as	as	IN
cord-316996-8yimrpaz	73	10	these	these	DT
cord-316996-8yimrpaz	73	11	changes	change	NNS
cord-316996-8yimrpaz	73	12	,	,	,
cord-316996-8yimrpaz	73	13	in	in	IN
cord-316996-8yimrpaz	73	14	particular	particular	JJ
cord-316996-8yimrpaz	73	15	O	o	NN
cord-316996-8yimrpaz	73	16	-	-	HYPH
cord-316996-8yimrpaz	73	17	acetylation	acetylation	NN
cord-316996-8yimrpaz	73	18	,	,	,
cord-316996-8yimrpaz	73	19	may	may	MD
cord-316996-8yimrpaz	73	20	have	have	VB
cord-316996-8yimrpaz	73	21	an	an	DT
cord-316996-8yimrpaz	73	22	effect	effect	NN
cord-316996-8yimrpaz	73	23	on	on	IN
cord-316996-8yimrpaz	73	24	enzymatic	enzymatic	JJ
cord-316996-8yimrpaz	73	25	cleavage	cleavage	NN
cord-316996-8yimrpaz	73	26	by	by	IN
cord-316996-8yimrpaz	73	27	sialidases	sialidase	NNS
cord-316996-8yimrpaz	73	28	.	.	.
cord-316996-8yimrpaz	74	1	Schauer	Schauer	NNP
cord-316996-8yimrpaz	74	2	demonstrated	demonstrate	VBD
cord-316996-8yimrpaz	74	3	that	that	IN
cord-316996-8yimrpaz	74	4	the	the	DT
cord-316996-8yimrpaz	74	5	position	position	NN
cord-316996-8yimrpaz	74	6	of	of	IN
cord-316996-8yimrpaz	74	7	acetylation	acetylation	NN
cord-316996-8yimrpaz	74	8	has	have	VBZ
cord-316996-8yimrpaz	74	9	an	an	DT
cord-316996-8yimrpaz	74	10	effect	effect	NN
cord-316996-8yimrpaz	74	11	on	on	IN
cord-316996-8yimrpaz	74	12	sialidase	sialidase	NN
cord-316996-8yimrpaz	74	13	activity	activity	NN
cord-316996-8yimrpaz	75	1	:	:	:
cord-316996-8yimrpaz	75	2	an	an	DT
cord-316996-8yimrpaz	75	3	O	o	NN
cord-316996-8yimrpaz	75	4	-	-	HYPH
cord-316996-8yimrpaz	75	5	acetyl	acetyl	NN
cord-316996-8yimrpaz	75	6	group	group	NN
cord-316996-8yimrpaz	75	7	on	on	IN
cord-316996-8yimrpaz	75	8	C	C	NNP
cord-316996-8yimrpaz	75	9	8	8	CD
cord-316996-8yimrpaz	75	10	reduces	reduce	VBZ
cord-316996-8yimrpaz	75	11	cleavage	cleavage	NN
cord-316996-8yimrpaz	75	12	by	by	IN
cord-316996-8yimrpaz	75	13	40	40	CD
cord-316996-8yimrpaz	75	14	%	%	NN
cord-316996-8yimrpaz	75	15	and	and	CC
cord-316996-8yimrpaz	75	16	at	at	IN
cord-316996-8yimrpaz	75	17	C	C	NNP
cord-316996-8yimrpaz	75	18	4	4	CD
cord-316996-8yimrpaz	75	19	by	by	IN
cord-316996-8yimrpaz	75	20	about	about	RB
cord-316996-8yimrpaz	75	21	80	80	CD
cord-316996-8yimrpaz	75	22	%	%	NN
cord-316996-8yimrpaz	75	23	(	(	-LRB-
cord-316996-8yimrpaz	75	24	Schauer	Schauer	NNP
cord-316996-8yimrpaz	75	25	,	,	,
cord-316996-8yimrpaz	75	26	1973	1973	CD
cord-316996-8yimrpaz	75	27	)	)	-RRB-
cord-316996-8yimrpaz	75	28	.	.	.
cord-316996-8yimrpaz	76	1	Bacteria	Bacteria	NNS
cord-316996-8yimrpaz	76	2	and	and	CC
cord-316996-8yimrpaz	76	3	some	some	DT
cord-316996-8yimrpaz	76	4	viruses	virus	NNS
cord-316996-8yimrpaz	76	5	(	(	-LRB-
cord-316996-8yimrpaz	76	6	notably	notably	RB
cord-316996-8yimrpaz	76	7	influenza	influenza	NN
cord-316996-8yimrpaz	76	8	C	C	NNP
cord-316996-8yimrpaz	76	9	virus	virus	NN
cord-316996-8yimrpaz	76	10	and	and	CC
cord-316996-8yimrpaz	76	11	coronaviruses	coronaviruse	NNS
cord-316996-8yimrpaz	76	12	)	)	-RRB-
cord-316996-8yimrpaz	76	13	have	have	VBP
cord-316996-8yimrpaz	76	14	circumvented	circumvent	VBN
cord-316996-8yimrpaz	76	15	this	this	DT
cord-316996-8yimrpaz	76	16	protective	protective	JJ
cord-316996-8yimrpaz	76	17	mechanism	mechanism	NN
cord-316996-8yimrpaz	76	18	through	through	IN
cord-316996-8yimrpaz	76	19	the	the	DT
cord-316996-8yimrpaz	76	20	development	development	NN
cord-316996-8yimrpaz	76	21	of	of	IN
cord-316996-8yimrpaz	76	22	esterases	esterases	NNP
cord-316996-8yimrpaz	76	23	located	locate	VBN
cord-316996-8yimrpaz	76	24	in	in	IN
cord-316996-8yimrpaz	76	25	the	the	DT
cord-316996-8yimrpaz	76	26	cytosol	cytosol	NN
cord-316996-8yimrpaz	76	27	or	or	CC
cord-316996-8yimrpaz	76	28	in	in	IN
cord-316996-8yimrpaz	76	29	lysozymes	lysozyme	NNS
cord-316996-8yimrpaz	76	30	.	.	.
cord-316996-8yimrpaz	77	1	Although	although	IN
cord-316996-8yimrpaz	77	2	influenza	influenza	NN
cord-316996-8yimrpaz	77	3	C	C	NNP
cord-316996-8yimrpaz	77	4	virus	virus	NN
cord-316996-8yimrpaz	77	5	appeared	appear	VBD
cord-316996-8yimrpaz	77	6	to	to	IN
cord-316996-8yimrpaz	77	7	lack	lack	VB
cord-316996-8yimrpaz	77	8	sialidase	sialidase	NN
cord-316996-8yimrpaz	77	9	activity	activity	NN
cord-316996-8yimrpaz	77	10	,	,	,
cord-316996-8yimrpaz	77	11	it	-PRON-	PRP
cord-316996-8yimrpaz	77	12	was	be	VBD
cord-316996-8yimrpaz	77	13	still	still	RB
cord-316996-8yimrpaz	77	14	able	able	JJ
cord-316996-8yimrpaz	77	15	to	to	TO
cord-316996-8yimrpaz	77	16	agglutinate	agglutinate	VB
cord-316996-8yimrpaz	77	17	red	red	JJ
cord-316996-8yimrpaz	77	18	blood	blood	NN
cord-316996-8yimrpaz	77	19	cells	cell	NNS
cord-316996-8yimrpaz	77	20	from	from	IN
cord-316996-8yimrpaz	77	21	certain	certain	JJ
cord-316996-8yimrpaz	77	22	species	specie	NNS
cord-316996-8yimrpaz	77	23	,	,	,
cord-316996-8yimrpaz	77	24	which	which	WDT
cord-316996-8yimrpaz	77	25	led	lead	VBD
cord-316996-8yimrpaz	77	26	to	to	IN
cord-316996-8yimrpaz	77	27	the	the	DT
cord-316996-8yimrpaz	77	28	finding	finding	NN
cord-316996-8yimrpaz	77	29	of	of	IN
cord-316996-8yimrpaz	77	30	an	an	DT
cord-316996-8yimrpaz	77	31	esterase	esterase	NN
cord-316996-8yimrpaz	77	32	combined	combine	VBN
cord-316996-8yimrpaz	77	33	with	with	IN
cord-316996-8yimrpaz	77	34	the	the	DT
cord-316996-8yimrpaz	77	35	haemagglutinin	haemagglutinin	NNP
cord-316996-8yimrpaz	77	36	and	and	CC
cord-316996-8yimrpaz	77	37	fusion	fusion	NN
cord-316996-8yimrpaz	77	38	protein	protein	NN
cord-316996-8yimrpaz	77	39	to	to	TO
cord-316996-8yimrpaz	77	40	form	form	VB
cord-316996-8yimrpaz	77	41	the	the	DT
cord-316996-8yimrpaz	77	42	HEF	HEF	NNP
cord-316996-8yimrpaz	77	43	that	that	WDT
cord-316996-8yimrpaz	77	44	is	be	VBZ
cord-316996-8yimrpaz	77	45	present	present	JJ
cord-316996-8yimrpaz	77	46	on	on	IN
cord-316996-8yimrpaz	77	47	influenza	influenza	NN
cord-316996-8yimrpaz	77	48	C	c	NN
cord-316996-8yimrpaz	77	49	and	and	CC
cord-316996-8yimrpaz	77	50	some	some	DT
cord-316996-8yimrpaz	77	51	coronaviruses	coronaviruse	NNS
cord-316996-8yimrpaz	78	1	(	(	-LRB-
cord-316996-8yimrpaz	78	2	Martin	Martin	NNP
cord-316996-8yimrpaz	78	3	et	et	NNP
cord-316996-8yimrpaz	78	4	al	al	NNP
cord-316996-8yimrpaz	78	5	.	.	NNP
cord-316996-8yimrpaz	78	6	,	,	,
cord-316996-8yimrpaz	78	7	2003	2003	CD
cord-316996-8yimrpaz	78	8	)	)	-RRB-
cord-316996-8yimrpaz	78	9	.	.	.
cord-316996-8yimrpaz	79	1	O	o	NN
cord-316996-8yimrpaz	79	2	-	-	HYPH
cord-316996-8yimrpaz	79	3	acetylation	acetylation	NN
cord-316996-8yimrpaz	79	4	is	be	VBZ
cord-316996-8yimrpaz	79	5	one	one	CD
cord-316996-8yimrpaz	79	6	of	of	IN
cord-316996-8yimrpaz	79	7	the	the	DT
cord-316996-8yimrpaz	79	8	most	most	RBS
cord-316996-8yimrpaz	79	9	common	common	JJ
cord-316996-8yimrpaz	79	10	modification	modification	NN
cord-316996-8yimrpaz	79	11	of	of	IN
cord-316996-8yimrpaz	79	12	sialic	sialic	JJ
cord-316996-8yimrpaz	79	13	acids	acid	NNS
cord-316996-8yimrpaz	79	14	,	,	,
cord-316996-8yimrpaz	79	15	and	and	CC
cord-316996-8yimrpaz	79	16	it	-PRON-	PRP
cord-316996-8yimrpaz	79	17	was	be	VBD
cord-316996-8yimrpaz	79	18	initially	initially	RB
cord-316996-8yimrpaz	79	19	thought	think	VBN
cord-316996-8yimrpaz	79	20	to	to	TO
cord-316996-8yimrpaz	79	21	be	be	VB
cord-316996-8yimrpaz	79	22	a	a	DT
cord-316996-8yimrpaz	79	23	species	species	NN
cord-316996-8yimrpaz	79	24	-	-	HYPH
cord-316996-8yimrpaz	79	25	specific	specific	JJ
cord-316996-8yimrpaz	79	26	determinant	determinant	NN
cord-316996-8yimrpaz	79	27	(	(	-LRB-
cord-316996-8yimrpaz	79	28	Klein	Klein	NNP
cord-316996-8yimrpaz	79	29	and	and	CC
cord-316996-8yimrpaz	79	30	Roussel	Roussel	NNP
cord-316996-8yimrpaz	79	31	,	,	,
cord-316996-8yimrpaz	79	32	1998	1998	CD
cord-316996-8yimrpaz	79	33	)	)	-RRB-
cord-316996-8yimrpaz	79	34	.	.	.
cord-316996-8yimrpaz	80	1	The	the	DT
cord-316996-8yimrpaz	80	2	tissue	tissue	NN
cord-316996-8yimrpaz	80	3	localization	localization	NN
cord-316996-8yimrpaz	80	4	of	of	IN
cord-316996-8yimrpaz	80	5	the	the	DT
cord-316996-8yimrpaz	80	6	9-Oacetylation	9-oacetylation	CD
cord-316996-8yimrpaz	80	7	variant	variant	NN
cord-316996-8yimrpaz	80	8	has	have	VBZ
cord-316996-8yimrpaz	80	9	been	be	VBN
cord-316996-8yimrpaz	80	10	investigated	investigate	VBN
cord-316996-8yimrpaz	80	11	by	by	IN
cord-316996-8yimrpaz	80	12	the	the	DT
cord-316996-8yimrpaz	80	13	use	use	NN
cord-316996-8yimrpaz	80	14	of	of	IN
cord-316996-8yimrpaz	80	15	specific	specific	JJ
cord-316996-8yimrpaz	80	16	monoclonal	monoclonal	JJ
cord-316996-8yimrpaz	80	17	antibodies	antibody	NNS
cord-316996-8yimrpaz	80	18	(	(	-LRB-
cord-316996-8yimrpaz	80	19	Argueso	Argueso	NNP
cord-316996-8yimrpaz	80	20	and	and	CC
cord-316996-8yimrpaz	80	21	Sumiyoshi	Sumiyoshi	NNP
cord-316996-8yimrpaz	80	22	,	,	,
cord-316996-8yimrpaz	80	23	2006	2006	CD
cord-316996-8yimrpaz	80	24	)	)	-RRB-
cord-316996-8yimrpaz	80	25	,	,	,
cord-316996-8yimrpaz	80	26	or	or	CC
cord-316996-8yimrpaz	80	27	binding	bind	VBG
cord-316996-8yimrpaz	80	28	by	by	IN
cord-316996-8yimrpaz	80	29	influenza	influenza	NN
cord-316996-8yimrpaz	80	30	C	c	NN
cord-316996-8yimrpaz	80	31	virus	virus	NN
cord-316996-8yimrpaz	80	32	or	or	CC
cord-316996-8yimrpaz	80	33	its	-PRON-	PRP$
cord-316996-8yimrpaz	80	34	recombinant	recombinant	JJ
cord-316996-8yimrpaz	80	35	soluble	soluble	JJ
cord-316996-8yimrpaz	80	36	form	form	NN
cord-316996-8yimrpaz	80	37	,	,	,
cord-316996-8yimrpaz	80	38	coupled	couple	VBN
cord-316996-8yimrpaz	80	39	with	with	IN
cord-316996-8yimrpaz	80	40	the	the	DT
cord-316996-8yimrpaz	80	41	Fc	Fc	NNP
cord-316996-8yimrpaz	80	42	portion	portion	NN
cord-316996-8yimrpaz	80	43	of	of	IN
cord-316996-8yimrpaz	80	44	human	human	JJ
cord-316996-8yimrpaz	80	45	immunoglobulin	immunoglobulin	NN
cord-316996-8yimrpaz	80	46	(	(	-LRB-
cord-316996-8yimrpaz	80	47	Che	che	NN
cord-316996-8yimrpaz	80	48	-	-	HYPH
cord-316996-8yimrpaz	80	49	FcD	fcd	NN
cord-316996-8yimrpaz	80	50	)	)	-RRB-
cord-316996-8yimrpaz	81	1	(	(	-LRB-
cord-316996-8yimrpaz	81	2	Mandal	Mandal	NNP
cord-316996-8yimrpaz	81	3	et	et	FW
cord-316996-8yimrpaz	81	4	al	al	NNP
cord-316996-8yimrpaz	81	5	.	.	NNP
cord-316996-8yimrpaz	81	6	,	,	,
cord-316996-8yimrpaz	81	7	2000	2000	CD
cord-316996-8yimrpaz	81	8	)	)	-RRB-
cord-316996-8yimrpaz	81	9	.	.	.
cord-316996-8yimrpaz	82	1	These	these	DT
cord-316996-8yimrpaz	82	2	studies	study	NNS
cord-316996-8yimrpaz	82	3	showed	show	VBD
cord-316996-8yimrpaz	82	4	that	that	IN
cord-316996-8yimrpaz	82	5	O	o	NN
cord-316996-8yimrpaz	82	6	-	-	HYPH
cord-316996-8yimrpaz	82	7	acetylation	acetylation	NN
cord-316996-8yimrpaz	82	8	of	of	IN
cord-316996-8yimrpaz	82	9	sialic	sialic	JJ
cord-316996-8yimrpaz	82	10	acid	acid	NN
cord-316996-8yimrpaz	82	11	in	in	IN
cord-316996-8yimrpaz	82	12	humans	human	NNS
cord-316996-8yimrpaz	82	13	appears	appear	VBZ
cord-316996-8yimrpaz	82	14	localized	localize	VBN
cord-316996-8yimrpaz	82	15	to	to	IN
cord-316996-8yimrpaz	82	16	the	the	DT
cord-316996-8yimrpaz	82	17	suprabasal	suprabasal	NNP
cord-316996-8yimrpaz	82	18	plasma	plasma	NN
cord-316996-8yimrpaz	82	19	membranes	membrane	NNS
cord-316996-8yimrpaz	82	20	of	of	IN
cord-316996-8yimrpaz	82	21	cells	cell	NNS
cord-316996-8yimrpaz	82	22	exposed	expose	VBN
cord-316996-8yimrpaz	82	23	to	to	IN
cord-316996-8yimrpaz	82	24	a	a	DT
cord-316996-8yimrpaz	82	25	'	'	``
cord-316996-8yimrpaz	82	26	'	'	``
cord-316996-8yimrpaz	82	27	wet	wet	JJ
cord-316996-8yimrpaz	82	28	'	'	''
cord-316996-8yimrpaz	82	29	'	'	''
cord-316996-8yimrpaz	82	30	surface	surface	NN
cord-316996-8yimrpaz	82	31	,	,	,
cord-316996-8yimrpaz	82	32	such	such	JJ
cord-316996-8yimrpaz	82	33	as	as	IN
cord-316996-8yimrpaz	82	34	the	the	DT
cord-316996-8yimrpaz	82	35	cornea	cornea	NN
cord-316996-8yimrpaz	82	36	,	,	,
cord-316996-8yimrpaz	82	37	conjunctiva	conjunctiva	NN
cord-316996-8yimrpaz	82	38	,	,	,
cord-316996-8yimrpaz	82	39	laryngeal	laryngeal	NN
cord-316996-8yimrpaz	82	40	and	and	CC
cord-316996-8yimrpaz	82	41	vaginal	vaginal	JJ
cord-316996-8yimrpaz	82	42	epithelium	epithelium	NN
cord-316996-8yimrpaz	82	43	.	.	.
cord-316996-8yimrpaz	83	1	There	there	EX
cord-316996-8yimrpaz	83	2	is	be	VBZ
cord-316996-8yimrpaz	83	3	a	a	DT
cord-316996-8yimrpaz	83	4	variation	variation	NN
cord-316996-8yimrpaz	83	5	in	in	IN
cord-316996-8yimrpaz	83	6	the	the	DT
cord-316996-8yimrpaz	83	7	degree	degree	NN
cord-316996-8yimrpaz	83	8	of	of	IN
cord-316996-8yimrpaz	83	9	O	o	NN
cord-316996-8yimrpaz	83	10	-	-	HYPH
cord-316996-8yimrpaz	83	11	acetylation	acetylation	NN
cord-316996-8yimrpaz	83	12	between	between	IN
cord-316996-8yimrpaz	83	13	ethnic	ethnic	JJ
cord-316996-8yimrpaz	83	14	backgrounds	background	NNS
cord-316996-8yimrpaz	83	15	,	,	,
cord-316996-8yimrpaz	83	16	depending	depend	VBG
cord-316996-8yimrpaz	83	17	on	on	IN
cord-316996-8yimrpaz	83	18	whether	whether	IN
cord-316996-8yimrpaz	83	19	individuals	individual	NNS
cord-316996-8yimrpaz	83	20	are	be	VBP
cord-316996-8yimrpaz	83	21	slow	slow	JJ
cord-316996-8yimrpaz	83	22	or	or	CC
cord-316996-8yimrpaz	83	23	fast	fast	JJ
cord-316996-8yimrpaz	83	24	acetylators	acetylator	NNS
cord-316996-8yimrpaz	83	25	.	.	.
cord-316996-8yimrpaz	84	1	Apart	apart	RB
cord-316996-8yimrpaz	84	2	from	from	IN
cord-316996-8yimrpaz	84	3	the	the	DT
cord-316996-8yimrpaz	84	4	sialidase	sialidase	NN
cord-316996-8yimrpaz	84	5	from	from	IN
cord-316996-8yimrpaz	84	6	Arthrobacter	Arthrobacter	NNP
cord-316996-8yimrpaz	84	7	urefaciens	urefaciens	NNP
cord-316996-8yimrpaz	84	8	,	,	,
cord-316996-8yimrpaz	84	9	Actinomyces	Actinomyces	NNP
cord-316996-8yimrpaz	84	10	viscosus	viscosus	NN
cord-316996-8yimrpaz	84	11	and	and	CC
cord-316996-8yimrpaz	84	12	to	to	IN
cord-316996-8yimrpaz	84	13	a	a	DT
cord-316996-8yimrpaz	84	14	lesser	less	JJR
cord-316996-8yimrpaz	84	15	extent	extent	NN
cord-316996-8yimrpaz	84	16	the	the	DT
cord-316996-8yimrpaz	84	17	sialidase	sialidase	NN
cord-316996-8yimrpaz	84	18	from	from	IN
cord-316996-8yimrpaz	84	19	Newcastle	Newcastle	NNP
cord-316996-8yimrpaz	84	20	disease	disease	NN
cord-316996-8yimrpaz	84	21	virus	virus	NN
cord-316996-8yimrpaz	84	22	,	,	,
cord-316996-8yimrpaz	84	23	other	other	JJ
cord-316996-8yimrpaz	84	24	sialidases	sialidase	NNS
cord-316996-8yimrpaz	84	25	are	be	VBP
cord-316996-8yimrpaz	84	26	apparently	apparently	RB
cord-316996-8yimrpaz	84	27	not	not	RB
cord-316996-8yimrpaz	84	28	effective	effective	JJ
cord-316996-8yimrpaz	84	29	at	at	IN
cord-316996-8yimrpaz	84	30	cleaving	cleave	VBG
cord-316996-8yimrpaz	84	31	the	the	DT
cord-316996-8yimrpaz	84	32	terminal	terminal	JJ
cord-316996-8yimrpaz	84	33	sialic	sialic	NN
cord-316996-8yimrpaz	84	34	acid	acid	NN
cord-316996-8yimrpaz	84	35	.	.	.
cord-316996-8yimrpaz	85	1	The	the	DT
cord-316996-8yimrpaz	85	2	O	o	NN
cord-316996-8yimrpaz	85	3	-	-	HYPH
cord-316996-8yimrpaz	85	4	acetylation	acetylation	NN
cord-316996-8yimrpaz	85	5	inhibits	inhibit	VBZ
cord-316996-8yimrpaz	85	6	sialidase	sialidase	NN
cord-316996-8yimrpaz	85	7	sterically	sterically	RB
cord-316996-8yimrpaz	85	8	,	,	,
cord-316996-8yimrpaz	85	9	and	and	CC
cord-316996-8yimrpaz	85	10	is	be	VBZ
cord-316996-8yimrpaz	85	11	not	not	RB
cord-316996-8yimrpaz	85	12	competitive	competitive	JJ
cord-316996-8yimrpaz	85	13	.	.	.
cord-316996-8yimrpaz	86	1	Thus	thus	RB
cord-316996-8yimrpaz	86	2	,	,	,
cord-316996-8yimrpaz	86	3	O	o	NN
cord-316996-8yimrpaz	86	4	-	-	HYPH
cord-316996-8yimrpaz	86	5	acetylation	acetylation	NN
cord-316996-8yimrpaz	86	6	of	of	IN
cord-316996-8yimrpaz	86	7	mucins	mucin	NNS
cord-316996-8yimrpaz	86	8	can	can	MD
cord-316996-8yimrpaz	86	9	protect	protect	VB
cord-316996-8yimrpaz	86	10	against	against	IN
cord-316996-8yimrpaz	86	11	the	the	DT
cord-316996-8yimrpaz	86	12	action	action	NN
cord-316996-8yimrpaz	86	13	of	of	IN
cord-316996-8yimrpaz	86	14	bacterial	bacterial	JJ
cord-316996-8yimrpaz	86	15	sialidases	sialidase	NNS
cord-316996-8yimrpaz	86	16	.	.	.
cord-316996-8yimrpaz	87	1	This	this	DT
cord-316996-8yimrpaz	87	2	O	o	NN
cord-316996-8yimrpaz	87	3	-	-	HYPH
cord-316996-8yimrpaz	87	4	acetlyation	acetlyation	NN
cord-316996-8yimrpaz	87	5	is	be	VBZ
cord-316996-8yimrpaz	87	6	conspicuous	conspicuous	JJ
cord-316996-8yimrpaz	87	7	on	on	IN
cord-316996-8yimrpaz	87	8	the	the	DT
cord-316996-8yimrpaz	87	9	terminal	terminal	JJ
cord-316996-8yimrpaz	87	10	aspect	aspect	NN
cord-316996-8yimrpaz	87	11	of	of	IN
cord-316996-8yimrpaz	87	12	MUC16	MUC16	NNP
cord-316996-8yimrpaz	87	13	,	,	,
cord-316996-8yimrpaz	87	14	a	a	DT
cord-316996-8yimrpaz	87	15	glycoprotein	glycoprotein	NN
cord-316996-8yimrpaz	87	16	with	with	IN
cord-316996-8yimrpaz	87	17	a	a	DT
cord-316996-8yimrpaz	87	18	long	long	JJ
cord-316996-8yimrpaz	87	19	extracellular	extracellular	JJ
cord-316996-8yimrpaz	87	20	domain	domain	NN
cord-316996-8yimrpaz	87	21	that	that	WDT
cord-316996-8yimrpaz	87	22	prevents	prevent	VBZ
cord-316996-8yimrpaz	87	23	infection	infection	NN
cord-316996-8yimrpaz	87	24	of	of	IN
cord-316996-8yimrpaz	87	25	the	the	DT
cord-316996-8yimrpaz	87	26	intact	intact	JJ
cord-316996-8yimrpaz	87	27	epithelium	epithelium	NN
cord-316996-8yimrpaz	87	28	.	.	.
cord-316996-8yimrpaz	88	1	The	the	DT
cord-316996-8yimrpaz	88	2	other	other	JJ
cord-316996-8yimrpaz	88	3	common	common	JJ
cord-316996-8yimrpaz	88	4	modification	modification	NN
cord-316996-8yimrpaz	88	5	is	be	VBZ
cord-316996-8yimrpaz	88	6	the	the	DT
cord-316996-8yimrpaz	88	7	addition	addition	NN
cord-316996-8yimrpaz	88	8	of	of	IN
cord-316996-8yimrpaz	88	9	an	an	DT
cord-316996-8yimrpaz	88	10	oxygen	oxygen	NN
cord-316996-8yimrpaz	88	11	to	to	IN
cord-316996-8yimrpaz	88	12	the	the	DT
cord-316996-8yimrpaz	88	13	C5	C5	NNP
cord-316996-8yimrpaz	88	14	to	to	TO
cord-316996-8yimrpaz	88	15	form	form	VB
cord-316996-8yimrpaz	88	16	N	n	CD
cord-316996-8yimrpaz	88	17	-	-	HYPH
cord-316996-8yimrpaz	88	18	glycolylneuraminic	glycolylneuraminic	NN
cord-316996-8yimrpaz	88	19	acid	acid	NN
cord-316996-8yimrpaz	88	20	(	(	-LRB-
cord-316996-8yimrpaz	88	21	Neu5Gc	Neu5Gc	NNP
cord-316996-8yimrpaz	88	22	)	)	-RRB-
cord-316996-8yimrpaz	88	23	,	,	,
cord-316996-8yimrpaz	88	24	through	through	IN
cord-316996-8yimrpaz	88	25	the	the	DT
cord-316996-8yimrpaz	88	26	action	action	NN
cord-316996-8yimrpaz	88	27	of	of	IN
cord-316996-8yimrpaz	88	28	the	the	DT
cord-316996-8yimrpaz	88	29	enzyme	enzyme	NN
cord-316996-8yimrpaz	88	30	cytidine	cytidine	NN
cord-316996-8yimrpaz	88	31	monophosphate	monophosphate	NNP
cord-316996-8yimrpaz	88	32	N	N	NNP
cord-316996-8yimrpaz	88	33	-	-	HYPH
cord-316996-8yimrpaz	88	34	acetylneuraminic	acetylneuraminic	NNP
cord-316996-8yimrpaz	88	35	hydroxylase	hydroxylase	NN
cord-316996-8yimrpaz	88	36	(	(	-LRB-
cord-316996-8yimrpaz	88	37	CMAH	CMAH	NNP
cord-316996-8yimrpaz	88	38	)	)	-RRB-
cord-316996-8yimrpaz	88	39	.	.	.
cord-316996-8yimrpaz	89	1	Many	many	JJ
cord-316996-8yimrpaz	89	2	studies	study	NNS
cord-316996-8yimrpaz	89	3	by	by	IN
cord-316996-8yimrpaz	89	4	Ajit	Ajit	NNP
cord-316996-8yimrpaz	89	5	Varki	Varki	NNP
cord-316996-8yimrpaz	89	6	and	and	CC
cord-316996-8yimrpaz	89	7	colleagues	colleague	NNS
cord-316996-8yimrpaz	89	8	have	have	VBP
cord-316996-8yimrpaz	89	9	shown	show	VBN
cord-316996-8yimrpaz	89	10	a	a	DT
cord-316996-8yimrpaz	89	11	high	high	JJ
cord-316996-8yimrpaz	89	12	expression	expression	NN
cord-316996-8yimrpaz	89	13	of	of	IN
cord-316996-8yimrpaz	89	14	this	this	DT
cord-316996-8yimrpaz	89	15	enzyme	enzyme	NN
cord-316996-8yimrpaz	89	16	in	in	IN
cord-316996-8yimrpaz	89	17	many	many	JJ
cord-316996-8yimrpaz	89	18	animal	animal	NN
cord-316996-8yimrpaz	89	19	species	specie	NNS
cord-316996-8yimrpaz	89	20	.	.	.
cord-316996-8yimrpaz	90	1	Humans	human	NNS
cord-316996-8yimrpaz	90	2	lack	lack	VBP
cord-316996-8yimrpaz	90	3	CMAH	CMAH	NNP
cord-316996-8yimrpaz	90	4	activity	activity	NN
cord-316996-8yimrpaz	90	5	and	and	CC
cord-316996-8yimrpaz	90	6	the	the	DT
cord-316996-8yimrpaz	90	7	only	only	JJ
cord-316996-8yimrpaz	90	8	source	source	NN
cord-316996-8yimrpaz	90	9	of	of	IN
cord-316996-8yimrpaz	90	10	Neu5Gc	Neu5Gc	NNP
cord-316996-8yimrpaz	91	1	is	be	VBZ
cord-316996-8yimrpaz	91	2	from	from	IN
cord-316996-8yimrpaz	91	3	the	the	DT
cord-316996-8yimrpaz	91	4	diet	diet	NN
cord-316996-8yimrpaz	91	5	.	.	.
cord-316996-8yimrpaz	92	1	This	this	DT
cord-316996-8yimrpaz	92	2	additional	additional	JJ
cord-316996-8yimrpaz	92	3	oxygen	oxygen	NN
cord-316996-8yimrpaz	92	4	is	be	VBZ
cord-316996-8yimrpaz	92	5	important	important	JJ
cord-316996-8yimrpaz	92	6	from	from	IN
cord-316996-8yimrpaz	92	7	a	a	DT
cord-316996-8yimrpaz	92	8	sialidase	sialidase	NN
cord-316996-8yimrpaz	92	9	point	point	NN
cord-316996-8yimrpaz	92	10	of	of	IN
cord-316996-8yimrpaz	92	11	view	view	NN
cord-316996-8yimrpaz	92	12	in	in	IN
cord-316996-8yimrpaz	92	13	that	that	DT
cord-316996-8yimrpaz	92	14	many	many	JJ
cord-316996-8yimrpaz	92	15	bacterial	bacterial	JJ
cord-316996-8yimrpaz	92	16	and	and	CC
cord-316996-8yimrpaz	92	17	viral	viral	JJ
cord-316996-8yimrpaz	92	18	sialidases	sialidase	NNS
cord-316996-8yimrpaz	92	19	preferably	preferably	RB
cord-316996-8yimrpaz	92	20	cleave	cleave	VBP
cord-316996-8yimrpaz	92	21	Neu5Ac	Neu5Ac	NNP
cord-316996-8yimrpaz	92	22	over	over	IN
cord-316996-8yimrpaz	92	23	Neu5Gc	Neu5Gc	NNPS
cord-316996-8yimrpaz	92	24	in	in	IN
cord-316996-8yimrpaz	92	25	the	the	DT
cord-316996-8yimrpaz	92	26	a2	a2	NNP
cord-316996-8yimrpaz	92	27	-	-	HYPH
cord-316996-8yimrpaz	92	28	3	3	CD
cord-316996-8yimrpaz	92	29	and	and	CC
cord-316996-8yimrpaz	92	30	a2	a2	NNP
cord-316996-8yimrpaz	92	31	-	-	HYPH
cord-316996-8yimrpaz	92	32	6	6	CD
cord-316996-8yimrpaz	92	33	configuration	configuration	NN
cord-316996-8yimrpaz	92	34	(	(	-LRB-
cord-316996-8yimrpaz	92	35	Davies	Davies	NNP
cord-316996-8yimrpaz	92	36	et	et	NNP
cord-316996-8yimrpaz	92	37	al	al	NNP
cord-316996-8yimrpaz	92	38	.	.	NNP
cord-316996-8yimrpaz	92	39	,	,	,
cord-316996-8yimrpaz	92	40	2012	2012	CD
cord-316996-8yimrpaz	92	41	)	)	-RRB-
cord-316996-8yimrpaz	92	42	.	.	.
cord-316996-8yimrpaz	93	1	Viral	viral	JJ
cord-316996-8yimrpaz	93	2	sialidases	sialidase	NNS
cord-316996-8yimrpaz	93	3	from	from	IN
cord-316996-8yimrpaz	93	4	Newcastle	Newcastle	NNP
cord-316996-8yimrpaz	93	5	disease	disease	NN
cord-316996-8yimrpaz	93	6	virus	virus	NN
cord-316996-8yimrpaz	93	7	,	,	,
cord-316996-8yimrpaz	93	8	fowl	fowl	NN
cord-316996-8yimrpaz	93	9	plague	plague	NN
cord-316996-8yimrpaz	93	10	and	and	CC
cord-316996-8yimrpaz	93	11	most	most	JJS
cord-316996-8yimrpaz	93	12	influenza	influenza	NN
cord-316996-8yimrpaz	93	13	viruses	virus	NNS
cord-316996-8yimrpaz	93	14	also	also	RB
cord-316996-8yimrpaz	93	15	show	show	VBP
cord-316996-8yimrpaz	93	16	poor	poor	JJ
cord-316996-8yimrpaz	93	17	cleavage	cleavage	NN
cord-316996-8yimrpaz	93	18	of	of	IN
cord-316996-8yimrpaz	93	19	Neu5Gc	Neu5Gc	NNPS
cord-316996-8yimrpaz	93	20	over	over	IN
cord-316996-8yimrpaz	93	21	Neu5Ac	Neu5Ac	NNP
cord-316996-8yimrpaz	93	22	.	.	.
cord-316996-8yimrpaz	94	1	Molecular	molecular	JJ
cord-316996-8yimrpaz	94	2	dynamic	dynamic	JJ
cord-316996-8yimrpaz	94	3	studies	study	NNS
cord-316996-8yimrpaz	94	4	suggest	suggest	VBP
cord-316996-8yimrpaz	94	5	that	that	IN
cord-316996-8yimrpaz	94	6	there	there	EX
cord-316996-8yimrpaz	94	7	is	be	VBZ
cord-316996-8yimrpaz	94	8	a	a	DT
cord-316996-8yimrpaz	94	9	conformational	conformational	JJ
cord-316996-8yimrpaz	94	10	change	change	NN
cord-316996-8yimrpaz	94	11	induced	induce	VBN
cord-316996-8yimrpaz	94	12	by	by	IN
cord-316996-8yimrpaz	94	13	the	the	DT
cord-316996-8yimrpaz	94	14	extra	extra	JJ
cord-316996-8yimrpaz	94	15	oxygen	oxygen	NN
cord-316996-8yimrpaz	94	16	that	that	WDT
cord-316996-8yimrpaz	94	17	may	may	MD
cord-316996-8yimrpaz	94	18	explain	explain	VB
cord-316996-8yimrpaz	94	19	this	this	DT
cord-316996-8yimrpaz	94	20	decreased	decrease	VBN
cord-316996-8yimrpaz	94	21	activity	activity	NN
cord-316996-8yimrpaz	94	22	.	.	.
cord-316996-8yimrpaz	95	1	If	if	IN
cord-316996-8yimrpaz	95	2	bacterial	bacterial	JJ
cord-316996-8yimrpaz	95	3	sialidases	sialidase	NNS
cord-316996-8yimrpaz	95	4	are	be	VBP
cord-316996-8yimrpaz	95	5	to	to	TO
cord-316996-8yimrpaz	95	6	be	be	VB
cord-316996-8yimrpaz	95	7	used	use	VBN
cord-316996-8yimrpaz	95	8	as	as	IN
cord-316996-8yimrpaz	95	9	potential	potential	JJ
cord-316996-8yimrpaz	95	10	therapeutic	therapeutic	JJ
cord-316996-8yimrpaz	95	11	agents	agent	NNS
cord-316996-8yimrpaz	95	12	,	,	,
cord-316996-8yimrpaz	95	13	these	these	DT
cord-316996-8yimrpaz	95	14	two	two	CD
cord-316996-8yimrpaz	95	15	changes	change	NNS
cord-316996-8yimrpaz	95	16	of	of	IN
cord-316996-8yimrpaz	95	17	O	o	NN
cord-316996-8yimrpaz	95	18	-	-	HYPH
cord-316996-8yimrpaz	95	19	acetylation	acetylation	NN
cord-316996-8yimrpaz	95	20	and	and	CC
cord-316996-8yimrpaz	95	21	Neu5Gc	Neu5Gc	NNPS
cord-316996-8yimrpaz	95	22	will	will	MD
cord-316996-8yimrpaz	95	23	have	have	VB
cord-316996-8yimrpaz	95	24	practical	practical	JJ
cord-316996-8yimrpaz	95	25	implications	implication	NNS
cord-316996-8yimrpaz	95	26	,	,	,
cord-316996-8yimrpaz	95	27	as	as	IN
cord-316996-8yimrpaz	95	28	the	the	DT
cord-316996-8yimrpaz	95	29	agent	agent	NN
cord-316996-8yimrpaz	95	30	will	will	MD
cord-316996-8yimrpaz	95	31	have	have	VB
cord-316996-8yimrpaz	95	32	to	to	TO
cord-316996-8yimrpaz	95	33	be	be	VB
cord-316996-8yimrpaz	95	34	one	one	NN
cord-316996-8yimrpaz	95	35	that	that	WDT
cord-316996-8yimrpaz	95	36	is	be	VBZ
cord-316996-8yimrpaz	95	37	able	able	JJ
cord-316996-8yimrpaz	95	38	to	to	TO
cord-316996-8yimrpaz	95	39	break	break	VB
cord-316996-8yimrpaz	95	40	through	through	IN
cord-316996-8yimrpaz	95	41	the	the	DT
cord-316996-8yimrpaz	95	42	mucin	mucin	NN
cord-316996-8yimrpaz	95	43	barrier	barrier	NN
cord-316996-8yimrpaz	95	44	to	to	TO
cord-316996-8yimrpaz	95	45	cleave	cleave	VB
cord-316996-8yimrpaz	95	46	sialic	sialic	JJ
cord-316996-8yimrpaz	95	47	acid	acid	NN
cord-316996-8yimrpaz	95	48	on	on	IN
cord-316996-8yimrpaz	95	49	the	the	DT
cord-316996-8yimrpaz	95	50	surface	surface	NN
cord-316996-8yimrpaz	95	51	of	of	IN
cord-316996-8yimrpaz	95	52	epithelial	epithelial	JJ
cord-316996-8yimrpaz	95	53	cells	cell	NNS
cord-316996-8yimrpaz	95	54	.	.	.
cord-316996-8yimrpaz	96	1	In	in	IN
cord-316996-8yimrpaz	96	2	the	the	DT
cord-316996-8yimrpaz	96	3	case	case	NN
cord-316996-8yimrpaz	96	4	of	of	IN
cord-316996-8yimrpaz	96	5	enzymatic	enzymatic	JJ
cord-316996-8yimrpaz	96	6	cleavage	cleavage	NN
cord-316996-8yimrpaz	96	7	of	of	IN
cord-316996-8yimrpaz	96	8	Neu5Gc	Neu5Gc	NNP
cord-316996-8yimrpaz	96	9	,	,	,
cord-316996-8yimrpaz	96	10	this	this	DT
cord-316996-8yimrpaz	96	11	enzymatic	enzymatic	JJ
cord-316996-8yimrpaz	96	12	cleavage	cleavage	NN
cord-316996-8yimrpaz	96	13	is	be	VBZ
cord-316996-8yimrpaz	96	14	unlikely	unlikely	JJ
cord-316996-8yimrpaz	96	15	to	to	TO
cord-316996-8yimrpaz	96	16	be	be	VB
cord-316996-8yimrpaz	96	17	a	a	DT
cord-316996-8yimrpaz	96	18	major	major	JJ
cord-316996-8yimrpaz	96	19	concern	concern	NN
cord-316996-8yimrpaz	96	20	,	,	,
cord-316996-8yimrpaz	96	21	because	because	IN
cord-316996-8yimrpaz	96	22	of	of	IN
cord-316996-8yimrpaz	96	23	the	the	DT
cord-316996-8yimrpaz	96	24	lack	lack	NN
cord-316996-8yimrpaz	96	25	of	of	IN
cord-316996-8yimrpaz	96	26	CMAH	CMAH	NNP
cord-316996-8yimrpaz	96	27	enzyme	enzyme	NN
cord-316996-8yimrpaz	96	28	in	in	IN
cord-316996-8yimrpaz	96	29	humans	human	NNS
cord-316996-8yimrpaz	96	30	,	,	,
cord-316996-8yimrpaz	96	31	and	and	CC
cord-316996-8yimrpaz	96	32	thus	thus	RB
cord-316996-8yimrpaz	96	33	the	the	DT
cord-316996-8yimrpaz	96	34	mucin	mucin	NN
cord-316996-8yimrpaz	96	35	is	be	VBZ
cord-316996-8yimrpaz	96	36	exclusively	exclusively	RB
cord-316996-8yimrpaz	96	37	Neu5Ac	Neu5Ac	NNP
cord-316996-8yimrpaz	96	38	.	.	.
cord-316996-8yimrpaz	97	1	However	however	RB
cord-316996-8yimrpaz	97	2	,	,	,
cord-316996-8yimrpaz	97	3	with	with	IN
cord-316996-8yimrpaz	97	4	O	o	NN
cord-316996-8yimrpaz	97	5	-	-	HYPH
cord-316996-8yimrpaz	97	6	acetylation	acetylation	NN
cord-316996-8yimrpaz	97	7	,	,	,
cord-316996-8yimrpaz	97	8	this	this	DT
cord-316996-8yimrpaz	97	9	enzymatic	enzymatic	JJ
cord-316996-8yimrpaz	97	10	cleavage	cleavage	NN
cord-316996-8yimrpaz	97	11	may	may	MD
cord-316996-8yimrpaz	97	12	be	be	VB
cord-316996-8yimrpaz	97	13	of	of	IN
cord-316996-8yimrpaz	97	14	concern	concern	NN
cord-316996-8yimrpaz	97	15	if	if	IN
cord-316996-8yimrpaz	97	16	topical	topical	JJ
cord-316996-8yimrpaz	97	17	therapy	therapy	NN
cord-316996-8yimrpaz	97	18	is	be	VBZ
cord-316996-8yimrpaz	97	19	to	to	TO
cord-316996-8yimrpaz	97	20	be	be	VB
cord-316996-8yimrpaz	97	21	used	use	VBN
cord-316996-8yimrpaz	97	22	in	in	IN
cord-316996-8yimrpaz	97	23	regions	region	NNS
cord-316996-8yimrpaz	97	24	of	of	IN
cord-316996-8yimrpaz	97	25	the	the	DT
cord-316996-8yimrpaz	97	26	body	body	NN
cord-316996-8yimrpaz	97	27	where	where	WRB
cord-316996-8yimrpaz	97	28	there	there	EX
cord-316996-8yimrpaz	97	29	is	be	VBZ
cord-316996-8yimrpaz	97	30	a	a	DT
cord-316996-8yimrpaz	97	31	high	high	JJ
cord-316996-8yimrpaz	97	32	degree	degree	NN
cord-316996-8yimrpaz	97	33	of	of	IN
cord-316996-8yimrpaz	97	34	O	o	NN
cord-316996-8yimrpaz	97	35	-	-	HYPH
cord-316996-8yimrpaz	97	36	acetylation	acetylation	NN
cord-316996-8yimrpaz	97	37	of	of	IN
cord-316996-8yimrpaz	97	38	non	non	JJ
cord-316996-8yimrpaz	97	39	-	-	JJ
cord-316996-8yimrpaz	97	40	keratinized	keratinized	JJ
cord-316996-8yimrpaz	97	41	stratified	stratified	JJ
cord-316996-8yimrpaz	97	42	squamous	squamous	JJ
cord-316996-8yimrpaz	97	43	epithelium	epithelium	NN
cord-316996-8yimrpaz	97	44	,	,	,
cord-316996-8yimrpaz	97	45	as	as	IN
cord-316996-8yimrpaz	97	46	is	be	VBZ
cord-316996-8yimrpaz	97	47	present	present	JJ
cord-316996-8yimrpaz	97	48	in	in	IN
cord-316996-8yimrpaz	97	49	the	the	DT
cord-316996-8yimrpaz	97	50	eye	eye	NN
cord-316996-8yimrpaz	97	51	and	and	CC
cord-316996-8yimrpaz	97	52	larynx	larynx	NN
cord-316996-8yimrpaz	97	53	.	.	.
cord-316996-8yimrpaz	98	1	In	in	IN
cord-316996-8yimrpaz	98	2	addition	addition	NN
cord-316996-8yimrpaz	98	3	to	to	IN
cord-316996-8yimrpaz	98	4	recognition	recognition	NN
cord-316996-8yimrpaz	98	5	by	by	IN
cord-316996-8yimrpaz	98	6	Siglecs	Siglecs	NNP
cord-316996-8yimrpaz	98	7	,	,	,
cord-316996-8yimrpaz	98	8	Sia	Sia	NNP
cord-316996-8yimrpaz	98	9	also	also	RB
cord-316996-8yimrpaz	98	10	functions	function	VBZ
cord-316996-8yimrpaz	98	11	as	as	IN
cord-316996-8yimrpaz	98	12	a	a	DT
cord-316996-8yimrpaz	98	13	receptor	receptor	NN
cord-316996-8yimrpaz	98	14	for	for	IN
cord-316996-8yimrpaz	98	15	a	a	DT
cord-316996-8yimrpaz	98	16	number	number	NN
cord-316996-8yimrpaz	98	17	of	of	IN
cord-316996-8yimrpaz	98	18	respiratory	respiratory	JJ
cord-316996-8yimrpaz	98	19	viral	viral	JJ
cord-316996-8yimrpaz	98	20	agents	agent	NNS
cord-316996-8yimrpaz	98	21	,	,	,
cord-316996-8yimrpaz	98	22	some	some	DT
cord-316996-8yimrpaz	98	23	of	of	IN
cord-316996-8yimrpaz	98	24	which	which	WDT
cord-316996-8yimrpaz	98	25	were	be	VBD
cord-316996-8yimrpaz	98	26	discovered	discover	VBN
cord-316996-8yimrpaz	98	27	by	by	IN
cord-316996-8yimrpaz	98	28	their	-PRON-	PRP$
cord-316996-8yimrpaz	98	29	ability	ability	NN
cord-316996-8yimrpaz	98	30	to	to	TO
cord-316996-8yimrpaz	98	31	cause	cause	VB
cord-316996-8yimrpaz	98	32	clumping	clumping	NN
cord-316996-8yimrpaz	98	33	or	or	CC
cord-316996-8yimrpaz	98	34	agglutination	agglutination	NN
cord-316996-8yimrpaz	98	35	of	of	IN
cord-316996-8yimrpaz	98	36	red	red	JJ
cord-316996-8yimrpaz	98	37	blood	blood	NN
cord-316996-8yimrpaz	98	38	cells	cell	NNS
cord-316996-8yimrpaz	98	39	in	in	IN
cord-316996-8yimrpaz	98	40	vitro	vitro	FW
cord-316996-8yimrpaz	98	41	(	(	-LRB-
cord-316996-8yimrpaz	98	42	haemagglutination	haemagglutination	NN
cord-316996-8yimrpaz	98	43	)	)	-RRB-
cord-316996-8yimrpaz	98	44	.	.	.
cord-316996-8yimrpaz	99	1	As	as	IN
cord-316996-8yimrpaz	99	2	viruses	virus	NNS
cord-316996-8yimrpaz	99	3	replicate	replicate	VBP
cord-316996-8yimrpaz	99	4	intracellularly	intracellularly	RB
cord-316996-8yimrpaz	99	5	,	,	,
cord-316996-8yimrpaz	99	6	it	-PRON-	PRP
cord-316996-8yimrpaz	99	7	follows	follow	VBZ
cord-316996-8yimrpaz	99	8	logically	logically	RB
cord-316996-8yimrpaz	99	9	that	that	IN
cord-316996-8yimrpaz	99	10	successful	successful	JJ
cord-316996-8yimrpaz	99	11	attachment	attachment	NN
cord-316996-8yimrpaz	99	12	to	to	IN
cord-316996-8yimrpaz	99	13	the	the	DT
cord-316996-8yimrpaz	99	14	cell	cell	NN
cord-316996-8yimrpaz	99	15	requires	require	VBZ
cord-316996-8yimrpaz	99	16	a	a	DT
cord-316996-8yimrpaz	99	17	matching	matching	NN
cord-316996-8yimrpaz	99	18	up	up	RP
cord-316996-8yimrpaz	99	19	of	of	IN
cord-316996-8yimrpaz	99	20	the	the	DT
cord-316996-8yimrpaz	99	21	receptor	receptor	NN
cord-316996-8yimrpaz	99	22	with	with	IN
cord-316996-8yimrpaz	99	23	the	the	DT
cord-316996-8yimrpaz	99	24	pathogen	pathogen	NN
cord-316996-8yimrpaz	99	25	.	.	.
cord-316996-8yimrpaz	100	1	This	this	DT
cord-316996-8yimrpaz	100	2	is	be	VBZ
cord-316996-8yimrpaz	100	3	often	often	RB
cord-316996-8yimrpaz	100	4	a	a	DT
cord-316996-8yimrpaz	100	5	two	two	CD
cord-316996-8yimrpaz	100	6	-	-	HYPH
cord-316996-8yimrpaz	100	7	step	step	NN
cord-316996-8yimrpaz	100	8	process	process	NN
cord-316996-8yimrpaz	100	9	:	:	:
cord-316996-8yimrpaz	100	10	first	first	RB
cord-316996-8yimrpaz	100	11	,	,	,
cord-316996-8yimrpaz	100	12	a	a	DT
cord-316996-8yimrpaz	100	13	low	low	JJ
cord-316996-8yimrpaz	100	14	-	-	HYPH
cord-316996-8yimrpaz	100	15	affinity	affinity	NN
cord-316996-8yimrpaz	100	16	'	'	''
cord-316996-8yimrpaz	100	17	'	'	''
cord-316996-8yimrpaz	100	18	browsing	browse	VBG
cord-316996-8yimrpaz	100	19	'	'	''
cord-316996-8yimrpaz	100	20	'	'	''
cord-316996-8yimrpaz	100	21	,	,	,
cord-316996-8yimrpaz	100	22	followed	follow	VBN
cord-316996-8yimrpaz	100	23	by	by	IN
cord-316996-8yimrpaz	100	24	a	a	DT
cord-316996-8yimrpaz	100	25	higher	high	JJR
cord-316996-8yimrpaz	100	26	-	-	HYPH
cord-316996-8yimrpaz	100	27	affinity	affinity	NN
cord-316996-8yimrpaz	100	28	interaction	interaction	NN
cord-316996-8yimrpaz	100	29	with	with	IN
cord-316996-8yimrpaz	100	30	the	the	DT
cord-316996-8yimrpaz	100	31	virus	virus	NN
cord-316996-8yimrpaz	100	32	,	,	,
cord-316996-8yimrpaz	100	33	and	and	CC
cord-316996-8yimrpaz	100	34	more	more	RBR
cord-316996-8yimrpaz	100	35	specific	specific	JJ
cord-316996-8yimrpaz	100	36	receptor	receptor	NN
cord-316996-8yimrpaz	100	37	interactions	interaction	NNS
cord-316996-8yimrpaz	100	38	(	(	-LRB-
cord-316996-8yimrpaz	100	39	Helander	Helander	NNP
cord-316996-8yimrpaz	100	40	et	et	NNP
cord-316996-8yimrpaz	100	41	al	al	NNP
cord-316996-8yimrpaz	100	42	.	.	NNP
cord-316996-8yimrpaz	100	43	,	,	,
cord-316996-8yimrpaz	100	44	2003	2003	CD
cord-316996-8yimrpaz	100	45	)	)	-RRB-
cord-316996-8yimrpaz	100	46	.	.	.
cord-316996-8yimrpaz	101	1	An	an	DT
cord-316996-8yimrpaz	101	2	extensive	extensive	JJ
cord-316996-8yimrpaz	101	3	list	list	NN
cord-316996-8yimrpaz	101	4	of	of	IN
cord-316996-8yimrpaz	101	5	viruses	virus	NNS
cord-316996-8yimrpaz	101	6	that	that	WDT
cord-316996-8yimrpaz	101	7	utilize	utilize	VBP
cord-316996-8yimrpaz	101	8	Sia	Sia	NNP
cord-316996-8yimrpaz	101	9	and	and	CC
cord-316996-8yimrpaz	101	10	which	which	WDT
cord-316996-8yimrpaz	101	11	may	may	MD
cord-316996-8yimrpaz	101	12	infect	infect	VB
cord-316996-8yimrpaz	101	13	the	the	DT
cord-316996-8yimrpaz	101	14	respiratory	respiratory	JJ
cord-316996-8yimrpaz	101	15	tract	tract	NN
cord-316996-8yimrpaz	101	16	has	have	VBZ
cord-316996-8yimrpaz	101	17	been	be	VBN
cord-316996-8yimrpaz	101	18	reviewed	review	VBN
cord-316996-8yimrpaz	101	19	by	by	IN
cord-316996-8yimrpaz	101	20	Lehmann	Lehmann	NNP
cord-316996-8yimrpaz	101	21	and	and	CC
cord-316996-8yimrpaz	101	22	colleagues	colleague	NNS
cord-316996-8yimrpaz	101	23	(	(	-LRB-
cord-316996-8yimrpaz	101	24	Lehmann	Lehmann	NNP
cord-316996-8yimrpaz	101	25	et	et	NNP
cord-316996-8yimrpaz	101	26	al	al	NNP
cord-316996-8yimrpaz	101	27	.	.	NNP
cord-316996-8yimrpaz	101	28	,	,	,
cord-316996-8yimrpaz	101	29	2006	2006	CD
cord-316996-8yimrpaz	101	30	)	)	-RRB-
cord-316996-8yimrpaz	101	31	.	.	.
cord-316996-8yimrpaz	102	1	Even	even	RB
cord-316996-8yimrpaz	102	2	though	though	IN
cord-316996-8yimrpaz	102	3	influenza	influenza	NN
cord-316996-8yimrpaz	102	4	virus	virus	NN
cord-316996-8yimrpaz	102	5	has	have	VBZ
cord-316996-8yimrpaz	102	6	been	be	VBN
cord-316996-8yimrpaz	102	7	the	the	DT
cord-316996-8yimrpaz	102	8	most	most	RBS
cord-316996-8yimrpaz	102	9	well	well	RB
cord-316996-8yimrpaz	102	10	characterized	characterize	VBN
cord-316996-8yimrpaz	102	11	of	of	IN
cord-316996-8yimrpaz	102	12	the	the	DT
cord-316996-8yimrpaz	102	13	pathogens	pathogen	NNS
cord-316996-8yimrpaz	102	14	studied	study	VBD
cord-316996-8yimrpaz	102	15	,	,	,
cord-316996-8yimrpaz	102	16	it	-PRON-	PRP
cord-316996-8yimrpaz	102	17	must	must	MD
cord-316996-8yimrpaz	102	18	be	be	VB
cord-316996-8yimrpaz	102	19	noted	note	VBN
cord-316996-8yimrpaz	102	20	that	that	IN
cord-316996-8yimrpaz	102	21	other	other	JJ
cord-316996-8yimrpaz	102	22	viruses	virus	NNS
cord-316996-8yimrpaz	102	23	,	,	,
cord-316996-8yimrpaz	102	24	including	include	VBG
cord-316996-8yimrpaz	102	25	cytomegalovirus	cytomegalovirus	NNP
cord-316996-8yimrpaz	102	26	(	(	-LRB-
cord-316996-8yimrpaz	102	27	Taylor	Taylor	NNP
cord-316996-8yimrpaz	102	28	and	and	CC
cord-316996-8yimrpaz	102	29	Cooper	Cooper	NNP
cord-316996-8yimrpaz	102	30	,	,	,
cord-316996-8yimrpaz	102	31	1989	1989	CD
cord-316996-8yimrpaz	102	32	)	)	-RRB-
cord-316996-8yimrpaz	102	33	,	,	,
cord-316996-8yimrpaz	102	34	rhinovirus	rhinovirus	NN
cord-316996-8yimrpaz	102	35	87	87	CD
cord-316996-8yimrpaz	102	36	(	(	-LRB-
cord-316996-8yimrpaz	102	37	Blomqvist	Blomqvist	NNP
cord-316996-8yimrpaz	102	38	et	et	FW
cord-316996-8yimrpaz	102	39	al	al	NNP
cord-316996-8yimrpaz	102	40	.	.	NNP
cord-316996-8yimrpaz	102	41	,	,	,
cord-316996-8yimrpaz	102	42	2002	2002	CD
cord-316996-8yimrpaz	102	43	)	)	-RRB-
cord-316996-8yimrpaz	102	44	,	,	,
cord-316996-8yimrpaz	102	45	mumps	mumps	NN
cord-316996-8yimrpaz	102	46	Urabe	Urabe	NNP
cord-316996-8yimrpaz	102	47	AM9	am9	NN
cord-316996-8yimrpaz	102	48	(	(	-LRB-
cord-316996-8yimrpaz	102	49	Reyes-	Reyes-	VBZ
cord-316996-8yimrpaz	102	50	Leyva	Leyva	NNP
cord-316996-8yimrpaz	102	51	et	et	NNP
cord-316996-8yimrpaz	102	52	al	al	NNP
cord-316996-8yimrpaz	102	53	.	.	NNP
cord-316996-8yimrpaz	102	54	,	,	,
cord-316996-8yimrpaz	102	55	2007	2007	CD
cord-316996-8yimrpaz	102	56	)	)	-RRB-
cord-316996-8yimrpaz	102	57	and	and	CC
cord-316996-8yimrpaz	102	58	the	the	DT
cord-316996-8yimrpaz	102	59	paramyxoviruses	paramyxovirus	NNS
cord-316996-8yimrpaz	102	60	all	all	DT
cord-316996-8yimrpaz	102	61	utilize	utilize	VBP
cord-316996-8yimrpaz	102	62	Sia	Sia	NNP
cord-316996-8yimrpaz	102	63	(	(	-LRB-
cord-316996-8yimrpaz	102	64	Suzuki	Suzuki	NNP
cord-316996-8yimrpaz	102	65	et	et	FW
cord-316996-8yimrpaz	102	66	al	al	NNP
cord-316996-8yimrpaz	102	67	.	.	NNP
cord-316996-8yimrpaz	102	68	,	,	,
cord-316996-8yimrpaz	102	69	2001	2001	CD
cord-316996-8yimrpaz	102	70	)	)	-RRB-
cord-316996-8yimrpaz	103	1	(	(	-LRB-
cord-316996-8yimrpaz	103	2	Paulson	Paulson	NNP
cord-316996-8yimrpaz	103	3	et	et	NNP
cord-316996-8yimrpaz	103	4	al	al	NNP
cord-316996-8yimrpaz	103	5	.	.	NNP
cord-316996-8yimrpaz	103	6	,	,	,
cord-316996-8yimrpaz	103	7	1979	1979	CD
cord-316996-8yimrpaz	103	8	)	)	-RRB-
cord-316996-8yimrpaz	103	9	,	,	,
cord-316996-8yimrpaz	103	10	suggesting	suggest	VBG
cord-316996-8yimrpaz	103	11	that	that	IN
cord-316996-8yimrpaz	103	12	sialidase	sialidase	NN
cord-316996-8yimrpaz	103	13	treatment	treatment	NN
cord-316996-8yimrpaz	103	14	may	may	MD
cord-316996-8yimrpaz	103	15	potentially	potentially	RB
cord-316996-8yimrpaz	103	16	be	be	VB
cord-316996-8yimrpaz	103	17	useful	useful	JJ
cord-316996-8yimrpaz	103	18	for	for	IN
cord-316996-8yimrpaz	103	19	these	these	DT
cord-316996-8yimrpaz	103	20	infections	infection	NNS
cord-316996-8yimrpaz	103	21	.	.	.
cord-316996-8yimrpaz	104	1	Bacteria	Bacteria	NNS
cord-316996-8yimrpaz	104	2	are	be	VBP
cord-316996-8yimrpaz	104	3	able	able	JJ
cord-316996-8yimrpaz	104	4	to	to	TO
cord-316996-8yimrpaz	104	5	produce	produce	VB
cord-316996-8yimrpaz	104	6	Sia	Sia	NNP
cord-316996-8yimrpaz	104	7	both	both	DT
cord-316996-8yimrpaz	104	8	through	through	IN
cord-316996-8yimrpaz	104	9	de	de	FW
cord-316996-8yimrpaz	104	10	novo	novo	NNP
cord-316996-8yimrpaz	104	11	synthesis	synthesis	NN
cord-316996-8yimrpaz	104	12	and	and	CC
cord-316996-8yimrpaz	104	13	by	by	IN
cord-316996-8yimrpaz	104	14	using	use	VBG
cord-316996-8yimrpaz	104	15	sialyl	sialyl	JJ
cord-316996-8yimrpaz	104	16	precursors	precursor	NNS
cord-316996-8yimrpaz	104	17	scavenged	scavenge	VBN
cord-316996-8yimrpaz	104	18	from	from	IN
cord-316996-8yimrpaz	104	19	animal	animal	NN
cord-316996-8yimrpaz	104	20	hosts	host	NNS
cord-316996-8yimrpaz	104	21	.	.	.
cord-316996-8yimrpaz	105	1	The	the	DT
cord-316996-8yimrpaz	105	2	syn	syn	NN
cord-316996-8yimrpaz	105	3	-	-	HYPH
cord-316996-8yimrpaz	105	4	thesis	thesis	NN
cord-316996-8yimrpaz	105	5	of	of	IN
cord-316996-8yimrpaz	105	6	Sia	Sia	NNP
cord-316996-8yimrpaz	105	7	in	in	IN
cord-316996-8yimrpaz	105	8	bacteria	bacteria	NNS
cord-316996-8yimrpaz	105	9	is	be	VBZ
cord-316996-8yimrpaz	105	10	limited	limit	VBN
cord-316996-8yimrpaz	105	11	to	to	IN
cord-316996-8yimrpaz	105	12	a	a	DT
cord-316996-8yimrpaz	105	13	few	few	JJ
cord-316996-8yimrpaz	105	14	,	,	,
cord-316996-8yimrpaz	105	15	mostly	mostly	RB
cord-316996-8yimrpaz	105	16	pathogenic	pathogenic	JJ
cord-316996-8yimrpaz	105	17	species	specie	NNS
cord-316996-8yimrpaz	105	18	that	that	WDT
cord-316996-8yimrpaz	105	19	incorporate	incorporate	VBP
cord-316996-8yimrpaz	105	20	Sia	Sia	NNP
cord-316996-8yimrpaz	105	21	into	into	IN
cord-316996-8yimrpaz	105	22	surface	surface	NN
cord-316996-8yimrpaz	105	23	structures	structure	NNS
cord-316996-8yimrpaz	105	24	,	,	,
cord-316996-8yimrpaz	105	25	such	such	JJ
cord-316996-8yimrpaz	105	26	as	as	IN
cord-316996-8yimrpaz	105	27	the	the	DT
cord-316996-8yimrpaz	105	28	capsular	capsular	JJ
cord-316996-8yimrpaz	105	29	polysialic	polysialic	JJ
cord-316996-8yimrpaz	105	30	acid	acid	NN
cord-316996-8yimrpaz	105	31	found	find	VBN
cord-316996-8yimrpaz	105	32	in	in	IN
cord-316996-8yimrpaz	105	33	Neisseria	Neisseria	NNP
cord-316996-8yimrpaz	105	34	meningitidis	meningitidis	NNP
cord-316996-8yimrpaz	105	35	and	and	CC
cord-316996-8yimrpaz	105	36	Escherichia	Escherichia	NNP
cord-316996-8yimrpaz	105	37	coli	coli	VBZ
cord-316996-8yimrpaz	105	38	K1	K1	NNP
cord-316996-8yimrpaz	105	39	(	(	-LRB-
cord-316996-8yimrpaz	105	40	Plumbridge	Plumbridge	NNP
cord-316996-8yimrpaz	105	41	and	and	CC
cord-316996-8yimrpaz	105	42	Vimr	Vimr	NNP
cord-316996-8yimrpaz	105	43	,	,	,
cord-316996-8yimrpaz	105	44	1999	1999	CD
cord-316996-8yimrpaz	105	45	)	)	-RRB-
cord-316996-8yimrpaz	105	46	.	.	.
cord-316996-8yimrpaz	106	1	The	the	DT
cord-316996-8yimrpaz	106	2	Sia	Sia	NNP
cord-316996-8yimrpaz	106	3	that	that	WDT
cord-316996-8yimrpaz	106	4	is	be	VBZ
cord-316996-8yimrpaz	106	5	incorporated	incorporate	VBN
cord-316996-8yimrpaz	106	6	or	or	CC
cord-316996-8yimrpaz	106	7	synthesized	synthesize	VBN
cord-316996-8yimrpaz	106	8	is	be	VBZ
cord-316996-8yimrpaz	106	9	used	use	VBN
cord-316996-8yimrpaz	106	10	as	as	IN
cord-316996-8yimrpaz	106	11	a	a	DT
cord-316996-8yimrpaz	106	12	growth	growth	NN
cord-316996-8yimrpaz	106	13	factor	factor	NN
cord-316996-8yimrpaz	106	14	or	or	CC
cord-316996-8yimrpaz	106	15	a	a	DT
cord-316996-8yimrpaz	106	16	source	source	NN
cord-316996-8yimrpaz	106	17	of	of	IN
cord-316996-8yimrpaz	106	18	carbon	carbon	NN
cord-316996-8yimrpaz	107	1	(	(	-LRB-
cord-316996-8yimrpaz	107	2	Kim	Kim	NNP
cord-316996-8yimrpaz	107	3	et	et	NNP
cord-316996-8yimrpaz	107	4	al	al	NNP
cord-316996-8yimrpaz	107	5	.	.	NNP
cord-316996-8yimrpaz	107	6	,	,	,
cord-316996-8yimrpaz	107	7	2011	2011	CD
cord-316996-8yimrpaz	107	8	;	;	:
cord-316996-8yimrpaz	108	1	Stafford	Stafford	NNP
cord-316996-8yimrpaz	108	2	et	et	NNP
cord-316996-8yimrpaz	108	3	al	al	NNP
cord-316996-8yimrpaz	108	4	.	.	NNP
cord-316996-8yimrpaz	108	5	,	,	,
cord-316996-8yimrpaz	108	6	2012	2012	CD
cord-316996-8yimrpaz	108	7	;	;	:
cord-316996-8yimrpaz	108	8	Vimr	Vimr	NNP
cord-316996-8yimrpaz	108	9	et	et	NNP
cord-316996-8yimrpaz	108	10	al	al	NNP
cord-316996-8yimrpaz	108	11	.	.	NNP
cord-316996-8yimrpaz	108	12	,	,	,
cord-316996-8yimrpaz	108	13	2004	2004	CD
cord-316996-8yimrpaz	108	14	)	)	-RRB-
cord-316996-8yimrpaz	108	15	.	.	.
cord-316996-8yimrpaz	109	1	Bacteria	Bacteria	NNS
cord-316996-8yimrpaz	109	2	that	that	WDT
cord-316996-8yimrpaz	109	3	utilize	utilize	VBP
cord-316996-8yimrpaz	109	4	Sia	Sia	NNP
cord-316996-8yimrpaz	109	5	include	include	VBP
cord-316996-8yimrpaz	109	6	Neisseria	Neisseria	NNP
cord-316996-8yimrpaz	109	7	,	,	,
cord-316996-8yimrpaz	109	8	Haemophilus	Haemophilus	NNP
cord-316996-8yimrpaz	109	9	,	,	,
cord-316996-8yimrpaz	109	10	Bacteroides	Bacteroides	NNP
cord-316996-8yimrpaz	109	11	,	,	,
cord-316996-8yimrpaz	109	12	Fusobacteria	Fusobacteria	NNP
cord-316996-8yimrpaz	109	13	and	and	CC
cord-316996-8yimrpaz	109	14	Streptococci	Streptococci	NNP
cord-316996-8yimrpaz	109	15	.	.	.
cord-316996-8yimrpaz	110	1	To	to	TO
cord-316996-8yimrpaz	110	2	achieve	achieve	VB
cord-316996-8yimrpaz	110	3	this	this	DT
cord-316996-8yimrpaz	110	4	scavenger	scavenger	NN
cord-316996-8yimrpaz	110	5	effect	effect	NN
cord-316996-8yimrpaz	110	6	,	,	,
cord-316996-8yimrpaz	110	7	a	a	DT
cord-316996-8yimrpaz	110	8	bacterium	bacterium	NN
cord-316996-8yimrpaz	110	9	first	first	RB
cord-316996-8yimrpaz	110	10	require	require	VBP
cord-316996-8yimrpaz	110	11	a	a	DT
cord-316996-8yimrpaz	110	12	sialidase	sialidase	NN
cord-316996-8yimrpaz	110	13	to	to	TO
cord-316996-8yimrpaz	110	14	remove	remove	VB
cord-316996-8yimrpaz	110	15	the	the	DT
cord-316996-8yimrpaz	110	16	Sia	Sia	NNP
cord-316996-8yimrpaz	110	17	from	from	IN
cord-316996-8yimrpaz	110	18	the	the	DT
cord-316996-8yimrpaz	110	19	host	host	NN
cord-316996-8yimrpaz	110	20	environment	environment	NN
cord-316996-8yimrpaz	110	21	,	,	,
cord-316996-8yimrpaz	110	22	then	then	RB
cord-316996-8yimrpaz	110	23	enzymes	enzyme	NNS
cord-316996-8yimrpaz	110	24	for	for	IN
cord-316996-8yimrpaz	110	25	catabolism	catabolism	NN
cord-316996-8yimrpaz	110	26	,	,	,
cord-316996-8yimrpaz	110	27	followed	follow	VBN
cord-316996-8yimrpaz	110	28	by	by	IN
cord-316996-8yimrpaz	110	29	uptake	uptake	NN
cord-316996-8yimrpaz	110	30	into	into	IN
cord-316996-8yimrpaz	110	31	the	the	DT
cord-316996-8yimrpaz	110	32	bacterium	bacterium	NN
cord-316996-8yimrpaz	110	33	for	for	IN
cord-316996-8yimrpaz	110	34	utilization	utilization	NN
cord-316996-8yimrpaz	110	35	.	.	.
cord-316996-8yimrpaz	111	1	The	the	DT
cord-316996-8yimrpaz	111	2	latter	latter	JJ
cord-316996-8yimrpaz	111	3	two	two	CD
cord-316996-8yimrpaz	111	4	steps	step	NNS
cord-316996-8yimrpaz	111	5	will	will	MD
cord-316996-8yimrpaz	111	6	not	not	RB
cord-316996-8yimrpaz	111	7	be	be	VB
cord-316996-8yimrpaz	111	8	elucidated	elucidate	VBN
cord-316996-8yimrpaz	111	9	further	further	RB
cord-316996-8yimrpaz	111	10	,	,	,
cord-316996-8yimrpaz	111	11	but	but	CC
cord-316996-8yimrpaz	111	12	an	an	DT
cord-316996-8yimrpaz	111	13	excellent	excellent	JJ
cord-316996-8yimrpaz	111	14	review	review	NN
cord-316996-8yimrpaz	111	15	on	on	IN
cord-316996-8yimrpaz	111	16	these	these	DT
cord-316996-8yimrpaz	111	17	processes	process	NNS
cord-316996-8yimrpaz	111	18	is	be	VBZ
cord-316996-8yimrpaz	111	19	available	available	JJ
cord-316996-8yimrpaz	112	1	(	(	-LRB-
cord-316996-8yimrpaz	112	2	Vimr	Vimr	NNP
cord-316996-8yimrpaz	112	3	et	et	NNP
cord-316996-8yimrpaz	112	4	al	al	NNP
cord-316996-8yimrpaz	112	5	.	.	NNP
cord-316996-8yimrpaz	112	6	,	,	,
cord-316996-8yimrpaz	112	7	2004	2004	CD
cord-316996-8yimrpaz	112	8	)	)	-RRB-
cord-316996-8yimrpaz	112	9	.	.	.
cord-316996-8yimrpaz	113	1	Another	another	DT
cord-316996-8yimrpaz	113	2	outcome	outcome	NN
cord-316996-8yimrpaz	113	3	of	of	IN
cord-316996-8yimrpaz	113	4	the	the	DT
cord-316996-8yimrpaz	113	5	sialylation	sialylation	NN
cord-316996-8yimrpaz	113	6	of	of	IN
cord-316996-8yimrpaz	113	7	bacterial	bacterial	JJ
cord-316996-8yimrpaz	113	8	surfaces	surface	NNS
cord-316996-8yimrpaz	113	9	is	be	VBZ
cord-316996-8yimrpaz	113	10	similar	similar	JJ
cord-316996-8yimrpaz	113	11	to	to	IN
cord-316996-8yimrpaz	113	12	that	that	DT
cord-316996-8yimrpaz	113	13	mentioned	mention	VBN
cord-316996-8yimrpaz	113	14	above	above	RB
cord-316996-8yimrpaz	113	15	for	for	IN
cord-316996-8yimrpaz	113	16	viruses	virus	NNS
cord-316996-8yimrpaz	113	17	,	,	,
cord-316996-8yimrpaz	113	18	in	in	IN
cord-316996-8yimrpaz	113	19	that	that	IN
cord-316996-8yimrpaz	113	20	they	-PRON-	PRP
cord-316996-8yimrpaz	113	21	are	be	VBP
cord-316996-8yimrpaz	113	22	able	able	JJ
cord-316996-8yimrpaz	113	23	to	to	TO
cord-316996-8yimrpaz	113	24	avoid	avoid	VB
cord-316996-8yimrpaz	113	25	recognition	recognition	NN
cord-316996-8yimrpaz	113	26	by	by	IN
cord-316996-8yimrpaz	113	27	the	the	DT
cord-316996-8yimrpaz	113	28	host	host	NN
cord-316996-8yimrpaz	113	29	defense	defense	NN
cord-316996-8yimrpaz	113	30	mechanisms	mechanism	NNS
cord-316996-8yimrpaz	113	31	,	,	,
cord-316996-8yimrpaz	113	32	as	as	IN
cord-316996-8yimrpaz	113	33	sialylation	sialylation	NN
cord-316996-8yimrpaz	113	34	results	result	NNS
cord-316996-8yimrpaz	113	35	in	in	IN
cord-316996-8yimrpaz	113	36	recognition	recognition	NN
cord-316996-8yimrpaz	113	37	as	as	IN
cord-316996-8yimrpaz	113	38	'	'	''
cord-316996-8yimrpaz	113	39	'	'	``
cord-316996-8yimrpaz	113	40	self	self	NN
cord-316996-8yimrpaz	113	41	'	'	''
cord-316996-8yimrpaz	113	42	'	'	''
cord-316996-8yimrpaz	113	43	rather	rather	RB
cord-316996-8yimrpaz	113	44	than	than	IN
cord-316996-8yimrpaz	113	45	'	'	''
cord-316996-8yimrpaz	113	46	'	'	``
cord-316996-8yimrpaz	113	47	foreign	foreign	JJ
cord-316996-8yimrpaz	113	48	'	'	''
cord-316996-8yimrpaz	113	49	'	'	''
cord-316996-8yimrpaz	113	50	.	.	.
cord-316996-8yimrpaz	114	1	Over	over	IN
cord-316996-8yimrpaz	114	2	70	70	CD
cord-316996-8yimrpaz	114	3	microorganisms	microorganism	NNS
cord-316996-8yimrpaz	114	4	have	have	VBP
cord-316996-8yimrpaz	114	5	sialidase	sialidase	NN
cord-316996-8yimrpaz	114	6	activity	activity	NN
cord-316996-8yimrpaz	114	7	,	,	,
cord-316996-8yimrpaz	114	8	and	and	CC
cord-316996-8yimrpaz	114	9	several	several	JJ
cord-316996-8yimrpaz	114	10	bacteria	bacteria	NNS
cord-316996-8yimrpaz	114	11	such	such	JJ
cord-316996-8yimrpaz	114	12	as	as	IN
cord-316996-8yimrpaz	114	13	Streptococcus	streptococcus	NN
cord-316996-8yimrpaz	114	14	pneumoniae	pneumoniae	NNS
cord-316996-8yimrpaz	114	15	produce	produce	VBP
cord-316996-8yimrpaz	114	16	more	more	JJR
cord-316996-8yimrpaz	114	17	than	than	IN
cord-316996-8yimrpaz	114	18	one	one	CD
cord-316996-8yimrpaz	114	19	sialidase	sialidase	NN
cord-316996-8yimrpaz	114	20	(	(	-LRB-
cord-316996-8yimrpaz	114	21	NanA	NanA	NNP
cord-316996-8yimrpaz	114	22	,	,	,
cord-316996-8yimrpaz	114	23	NanB	NanB	NNP
cord-316996-8yimrpaz	114	24	,	,	,
cord-316996-8yimrpaz	114	25	and	and	CC
cord-316996-8yimrpaz	114	26	NanC	NanC	NNP
cord-316996-8yimrpaz	114	27	)	)	-RRB-
cord-316996-8yimrpaz	115	1	(	(	-LRB-
cord-316996-8yimrpaz	115	2	Gut	Gut	NNP
cord-316996-8yimrpaz	115	3	et	et	FW
cord-316996-8yimrpaz	115	4	al	al	NNP
cord-316996-8yimrpaz	115	5	.	.	NNP
cord-316996-8yimrpaz	115	6	,	,	,
cord-316996-8yimrpaz	115	7	2008	2008	CD
cord-316996-8yimrpaz	115	8	)	)	-RRB-
cord-316996-8yimrpaz	115	9	.	.	.
cord-316996-8yimrpaz	116	1	The	the	DT
cord-316996-8yimrpaz	116	2	sialidases	sialidase	NNS
cord-316996-8yimrpaz	116	3	of	of	IN
cord-316996-8yimrpaz	116	4	S.	S.	NNP
cord-316996-8yimrpaz	116	5	pneumoniae	pneumoniae	NN
cord-316996-8yimrpaz	116	6	may	may	MD
cord-316996-8yimrpaz	116	7	expose	expose	VB
cord-316996-8yimrpaz	116	8	host	host	NN
cord-316996-8yimrpaz	116	9	receptors	receptor	NNS
cord-316996-8yimrpaz	116	10	and	and	CC
cord-316996-8yimrpaz	116	11	desialylate	desialylate	NNP
cord-316996-8yimrpaz	116	12	host	host	NN
cord-316996-8yimrpaz	116	13	glycoproteins	glycoprotein	NNS
cord-316996-8yimrpaz	116	14	such	such	JJ
cord-316996-8yimrpaz	116	15	as	as	IN
cord-316996-8yimrpaz	116	16	lactoferrin	lactoferrin	NNP
cord-316996-8yimrpaz	116	17	and	and	CC
cord-316996-8yimrpaz	116	18	immunoglobulin	immunoglobulin	NN
cord-316996-8yimrpaz	116	19	that	that	IN
cord-316996-8yimrpaz	116	20	clear	clear	JJ
cord-316996-8yimrpaz	116	21	bacteria	bacteria	NNS
cord-316996-8yimrpaz	116	22	.	.	.
cord-316996-8yimrpaz	117	1	They	-PRON-	PRP
cord-316996-8yimrpaz	117	2	may	may	MD
cord-316996-8yimrpaz	117	3	also	also	RB
cord-316996-8yimrpaz	117	4	lead	lead	VB
cord-316996-8yimrpaz	117	5	to	to	IN
cord-316996-8yimrpaz	117	6	the	the	DT
cord-316996-8yimrpaz	117	7	desialylation	desialylation	NN
cord-316996-8yimrpaz	117	8	of	of	IN
cord-316996-8yimrpaz	117	9	the	the	DT
cord-316996-8yimrpaz	117	10	lipopolysaccharides	lipopolysaccharide	NNS
cord-316996-8yimrpaz	117	11	of	of	IN
cord-316996-8yimrpaz	117	12	other	other	JJ
cord-316996-8yimrpaz	117	13	bacteria	bacteria	NNS
cord-316996-8yimrpaz	117	14	such	such	JJ
cord-316996-8yimrpaz	117	15	as	as	IN
cord-316996-8yimrpaz	117	16	N.	N.	NNP
cord-316996-8yimrpaz	117	17	meningitidis	meningitidis	NNP
cord-316996-8yimrpaz	117	18	and	and	CC
cord-316996-8yimrpaz	117	19	Haemophilus	Haemophilus	NNP
cord-316996-8yimrpaz	117	20	influenza	influenza	NN
cord-316996-8yimrpaz	117	21	,	,	,
cord-316996-8yimrpaz	117	22	giving	give	VBG
cord-316996-8yimrpaz	117	23	the	the	DT
cord-316996-8yimrpaz	117	24	pneumococcus	pneumococcus	NN
cord-316996-8yimrpaz	117	25	a	a	DT
cord-316996-8yimrpaz	117	26	competitive	competitive	JJ
cord-316996-8yimrpaz	117	27	growth	growth	NN
cord-316996-8yimrpaz	117	28	advantage	advantage	NN
cord-316996-8yimrpaz	117	29	(	(	-LRB-
cord-316996-8yimrpaz	117	30	Pettigrew	Pettigrew	NNP
cord-316996-8yimrpaz	117	31	et	et	NNP
cord-316996-8yimrpaz	117	32	al	al	NNP
cord-316996-8yimrpaz	117	33	.	.	NNP
cord-316996-8yimrpaz	117	34	,	,	,
cord-316996-8yimrpaz	117	35	2006	2006	CD
cord-316996-8yimrpaz	117	36	)	)	-RRB-
cord-316996-8yimrpaz	117	37	.	.	.
cord-316996-8yimrpaz	118	1	The	the	DT
cord-316996-8yimrpaz	118	2	NanA	NanA	NNP
cord-316996-8yimrpaz	118	3	is	be	VBZ
cord-316996-8yimrpaz	118	4	cell	cell	NN
cord-316996-8yimrpaz	118	5	surface	surface	NN
cord-316996-8yimrpaz	118	6	-	-	HYPH
cord-316996-8yimrpaz	118	7	anchored	anchor	VBN
cord-316996-8yimrpaz	118	8	,	,	,
cord-316996-8yimrpaz	118	9	and	and	CC
cord-316996-8yimrpaz	118	10	functions	function	NNS
cord-316996-8yimrpaz	118	11	in	in	IN
cord-316996-8yimrpaz	118	12	adherence	adherence	NN
cord-316996-8yimrpaz	118	13	.	.	.
cord-316996-8yimrpaz	119	1	It	-PRON-	PRP
cord-316996-8yimrpaz	119	2	may	may	MD
cord-316996-8yimrpaz	119	3	also	also	RB
cord-316996-8yimrpaz	119	4	provide	provide	VB
cord-316996-8yimrpaz	119	5	a	a	DT
cord-316996-8yimrpaz	119	6	carbon	carbon	NN
cord-316996-8yimrpaz	119	7	source	source	NN
cord-316996-8yimrpaz	119	8	for	for	IN
cord-316996-8yimrpaz	119	9	the	the	DT
cord-316996-8yimrpaz	119	10	bacterium	bacterium	NN
cord-316996-8yimrpaz	119	11	.	.	.
cord-316996-8yimrpaz	120	1	Similar	similar	JJ
cord-316996-8yimrpaz	120	2	to	to	IN
cord-316996-8yimrpaz	120	3	many	many	JJ
cord-316996-8yimrpaz	120	4	other	other	JJ
cord-316996-8yimrpaz	120	5	bacterial	bacterial	JJ
cord-316996-8yimrpaz	120	6	sialidases	sialidase	NNS
cord-316996-8yimrpaz	120	7	,	,	,
cord-316996-8yimrpaz	120	8	NanB	NanB	NNP
cord-316996-8yimrpaz	120	9	is	be	VBZ
cord-316996-8yimrpaz	120	10	secreted	secrete	VBN
cord-316996-8yimrpaz	120	11	as	as	IN
cord-316996-8yimrpaz	120	12	an	an	DT
cord-316996-8yimrpaz	120	13	extracellular	extracellular	JJ
cord-316996-8yimrpaz	120	14	enzyme	enzyme	NN
cord-316996-8yimrpaz	120	15	and	and	CC
cord-316996-8yimrpaz	120	16	implicated	implicate	VBN
cord-316996-8yimrpaz	120	17	in	in	IN
cord-316996-8yimrpaz	120	18	the	the	DT
cord-316996-8yimrpaz	120	19	severity	severity	NN
cord-316996-8yimrpaz	120	20	of	of	IN
cord-316996-8yimrpaz	120	21	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	120	22	infection	infection	NN
cord-316996-8yimrpaz	120	23	(	(	-LRB-
cord-316996-8yimrpaz	120	24	Manco	Manco	NNP
cord-316996-8yimrpaz	120	25	et	et	FW
cord-316996-8yimrpaz	120	26	al	al	NNP
cord-316996-8yimrpaz	120	27	.	.	NNP
cord-316996-8yimrpaz	120	28	,	,	,
cord-316996-8yimrpaz	120	29	2006	2006	CD
cord-316996-8yimrpaz	120	30	)	)	-RRB-
cord-316996-8yimrpaz	120	31	.	.	.
cord-316996-8yimrpaz	121	1	Desialylation	Desialylation	NNP
cord-316996-8yimrpaz	121	2	may	may	MD
cord-316996-8yimrpaz	121	3	also	also	RB
cord-316996-8yimrpaz	121	4	involve	involve	VB
cord-316996-8yimrpaz	121	5	the	the	DT
cord-316996-8yimrpaz	121	6	respiratory	respiratory	JJ
cord-316996-8yimrpaz	121	7	epithelium	epithelium	NN
cord-316996-8yimrpaz	121	8	,	,	,
cord-316996-8yimrpaz	121	9	and	and	CC
cord-316996-8yimrpaz	121	10	there	there	EX
cord-316996-8yimrpaz	121	11	have	have	VBP
cord-316996-8yimrpaz	121	12	been	be	VBN
cord-316996-8yimrpaz	121	13	previous	previous	JJ
cord-316996-8yimrpaz	121	14	concerns	concern	NNS
cord-316996-8yimrpaz	121	15	as	as	IN
cord-316996-8yimrpaz	121	16	to	to	IN
cord-316996-8yimrpaz	121	17	whether	whether	IN
cord-316996-8yimrpaz	121	18	the	the	DT
cord-316996-8yimrpaz	121	19	desialylation	desialylation	NN
cord-316996-8yimrpaz	121	20	of	of	IN
cord-316996-8yimrpaz	121	21	an	an	DT
cord-316996-8yimrpaz	121	22	epithelium	epithelium	NN
cord-316996-8yimrpaz	121	23	by	by	IN
cord-316996-8yimrpaz	121	24	bacterial	bacterial	JJ
cord-316996-8yimrpaz	121	25	or	or	CC
cord-316996-8yimrpaz	121	26	viral	viral	JJ
cord-316996-8yimrpaz	121	27	sialidases	sialidase	NNS
cord-316996-8yimrpaz	121	28	may	may	MD
cord-316996-8yimrpaz	121	29	lead	lead	VB
cord-316996-8yimrpaz	121	30	to	to	IN
cord-316996-8yimrpaz	121	31	increased	increase	VBN
cord-316996-8yimrpaz	121	32	bacterial	bacterial	JJ
cord-316996-8yimrpaz	121	33	adherence	adherence	NN
cord-316996-8yimrpaz	121	34	and	and	CC
cord-316996-8yimrpaz	121	35	superinfection	superinfection	NN
cord-316996-8yimrpaz	121	36	.	.	.
cord-316996-8yimrpaz	122	1	It	-PRON-	PRP
cord-316996-8yimrpaz	122	2	has	have	VBZ
cord-316996-8yimrpaz	122	3	been	be	VBN
cord-316996-8yimrpaz	122	4	well	well	RB
cord-316996-8yimrpaz	122	5	recognized	recognize	VBN
cord-316996-8yimrpaz	122	6	that	that	IN
cord-316996-8yimrpaz	122	7	patients	patient	NNS
cord-316996-8yimrpaz	122	8	with	with	IN
cord-316996-8yimrpaz	122	9	influenza	influenza	NN
cord-316996-8yimrpaz	122	10	are	be	VBP
cord-316996-8yimrpaz	122	11	susceptible	susceptible	JJ
cord-316996-8yimrpaz	122	12	to	to	IN
cord-316996-8yimrpaz	122	13	secondary	secondary	JJ
cord-316996-8yimrpaz	122	14	bacterial	bacterial	JJ
cord-316996-8yimrpaz	122	15	infection	infection	NN
cord-316996-8yimrpaz	123	1	(	(	-LRB-
cord-316996-8yimrpaz	123	2	van	van	NNP
cord-316996-8yimrpaz	123	3	der	der	NNP
cord-316996-8yimrpaz	123	4	Sluijs	Sluijs	NNP
cord-316996-8yimrpaz	123	5	et	et	FW
cord-316996-8yimrpaz	123	6	al	al	NNP
cord-316996-8yimrpaz	123	7	.	.	NNP
cord-316996-8yimrpaz	123	8	,	,	,
cord-316996-8yimrpaz	123	9	2006	2006	CD
cord-316996-8yimrpaz	123	10	)	)	-RRB-
cord-316996-8yimrpaz	123	11	,	,	,
cord-316996-8yimrpaz	123	12	and	and	CC
cord-316996-8yimrpaz	123	13	the	the	DT
cord-316996-8yimrpaz	123	14	high	high	JJ
cord-316996-8yimrpaz	123	15	mortality	mortality	NN
cord-316996-8yimrpaz	123	16	of	of	IN
cord-316996-8yimrpaz	123	17	the	the	DT
cord-316996-8yimrpaz	123	18	1918	1918	CD
cord-316996-8yimrpaz	123	19	influenza	influenza	NN
cord-316996-8yimrpaz	123	20	pandemic	pandemic	NN
cord-316996-8yimrpaz	123	21	has	have	VBZ
cord-316996-8yimrpaz	123	22	been	be	VBN
cord-316996-8yimrpaz	123	23	attributed	attribute	VBN
cord-316996-8yimrpaz	123	24	to	to	IN
cord-316996-8yimrpaz	123	25	secondary	secondary	JJ
cord-316996-8yimrpaz	123	26	infections	infection	NNS
cord-316996-8yimrpaz	123	27	(	(	-LRB-
cord-316996-8yimrpaz	123	28	Brundage	Brundage	NNP
cord-316996-8yimrpaz	123	29	and	and	CC
cord-316996-8yimrpaz	123	30	Shanks	Shanks	NNP
cord-316996-8yimrpaz	123	31	,	,	,
cord-316996-8yimrpaz	123	32	2008	2008	CD
cord-316996-8yimrpaz	123	33	)	)	-RRB-
cord-316996-8yimrpaz	123	34	.	.	.
cord-316996-8yimrpaz	124	1	If	if	IN
cord-316996-8yimrpaz	124	2	sialidase	sialidase	NN
cord-316996-8yimrpaz	124	3	is	be	VBZ
cord-316996-8yimrpaz	124	4	to	to	TO
cord-316996-8yimrpaz	124	5	be	be	VB
cord-316996-8yimrpaz	124	6	used	use	VBN
cord-316996-8yimrpaz	124	7	as	as	IN
cord-316996-8yimrpaz	124	8	a	a	DT
cord-316996-8yimrpaz	124	9	prophylactic	prophylactic	JJ
cord-316996-8yimrpaz	124	10	or	or	CC
cord-316996-8yimrpaz	124	11	therapeutic	therapeutic	JJ
cord-316996-8yimrpaz	124	12	strategy	strategy	NN
cord-316996-8yimrpaz	124	13	,	,	,
cord-316996-8yimrpaz	124	14	there	there	EX
cord-316996-8yimrpaz	124	15	have	have	VBP
cord-316996-8yimrpaz	124	16	therefore	therefore	RB
cord-316996-8yimrpaz	124	17	been	be	VBN
cord-316996-8yimrpaz	124	18	concerns	concern	NNS
cord-316996-8yimrpaz	124	19	that	that	IN
cord-316996-8yimrpaz	124	20	this	this	DT
cord-316996-8yimrpaz	124	21	may	may	MD
cord-316996-8yimrpaz	124	22	lead	lead	VB
cord-316996-8yimrpaz	124	23	to	to	IN
cord-316996-8yimrpaz	124	24	increased	increase	VBN
cord-316996-8yimrpaz	124	25	bacterial	bacterial	JJ
cord-316996-8yimrpaz	124	26	adherence	adherence	NN
cord-316996-8yimrpaz	124	27	and	and	CC
cord-316996-8yimrpaz	124	28	secondary	secondary	JJ
cord-316996-8yimrpaz	124	29	bacterial	bacterial	JJ
cord-316996-8yimrpaz	124	30	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	124	31	(	(	-LRB-
cord-316996-8yimrpaz	124	32	Zhang	Zhang	NNP
cord-316996-8yimrpaz	124	33	,	,	,
cord-316996-8yimrpaz	124	34	2008	2008	CD
cord-316996-8yimrpaz	124	35	)	)	-RRB-
cord-316996-8yimrpaz	124	36	.	.	.
cord-316996-8yimrpaz	125	1	In	in	IN
cord-316996-8yimrpaz	125	2	reality	reality	NN
cord-316996-8yimrpaz	125	3	,	,	,
cord-316996-8yimrpaz	125	4	increased	increase	VBN
cord-316996-8yimrpaz	125	5	adherence	adherence	NN
cord-316996-8yimrpaz	125	6	is	be	VBZ
cord-316996-8yimrpaz	125	7	due	due	JJ
cord-316996-8yimrpaz	125	8	to	to	IN
cord-316996-8yimrpaz	125	9	epithelial	epithelial	JJ
cord-316996-8yimrpaz	125	10	necrosis	necrosis	NN
cord-316996-8yimrpaz	125	11	and	and	CC
cord-316996-8yimrpaz	125	12	exposure	exposure	NN
cord-316996-8yimrpaz	125	13	of	of	IN
cord-316996-8yimrpaz	125	14	the	the	DT
cord-316996-8yimrpaz	125	15	basement	basement	NN
cord-316996-8yimrpaz	125	16	membranes	membrane	NNS
cord-316996-8yimrpaz	125	17	as	as	IN
cord-316996-8yimrpaz	125	18	a	a	DT
cord-316996-8yimrpaz	125	19	result	result	NN
cord-316996-8yimrpaz	125	20	of	of	IN
cord-316996-8yimrpaz	125	21	viral	viral	RB
cord-316996-8yimrpaz	125	22	-	-	HYPH
cord-316996-8yimrpaz	125	23	induced	induce	VBN
cord-316996-8yimrpaz	125	24	cell	cell	NN
cord-316996-8yimrpaz	125	25	death	death	NN
cord-316996-8yimrpaz	125	26	(	(	-LRB-
cord-316996-8yimrpaz	125	27	Plotkowski	Plotkowski	NNP
cord-316996-8yimrpaz	125	28	et	et	NNP
cord-316996-8yimrpaz	125	29	al	al	NNP
cord-316996-8yimrpaz	125	30	.	.	NNP
cord-316996-8yimrpaz	125	31	,	,	,
cord-316996-8yimrpaz	125	32	1986	1986	CD
cord-316996-8yimrpaz	125	33	)	)	-RRB-
cord-316996-8yimrpaz	125	34	,	,	,
cord-316996-8yimrpaz	125	35	rather	rather	RB
cord-316996-8yimrpaz	125	36	than	than	IN
cord-316996-8yimrpaz	125	37	surface	surface	NN
cord-316996-8yimrpaz	125	38	-	-	HYPH
cord-316996-8yimrpaz	125	39	induced	induce	VBN
cord-316996-8yimrpaz	125	40	desialylation	desialylation	NN
cord-316996-8yimrpaz	125	41	,	,	,
cord-316996-8yimrpaz	125	42	which	which	WDT
cord-316996-8yimrpaz	125	43	was	be	VBD
cord-316996-8yimrpaz	125	44	not	not	RB
cord-316996-8yimrpaz	125	45	associated	associate	VBN
cord-316996-8yimrpaz	125	46	with	with	IN
cord-316996-8yimrpaz	125	47	epithelial	epithelial	JJ
cord-316996-8yimrpaz	125	48	cell	cell	NN
cord-316996-8yimrpaz	125	49	death	death	NN
cord-316996-8yimrpaz	125	50	(	(	-LRB-
cord-316996-8yimrpaz	125	51	Nicholls	Nicholls	NNP
cord-316996-8yimrpaz	125	52	et	et	NNP
cord-316996-8yimrpaz	125	53	al	al	NNP
cord-316996-8yimrpaz	125	54	.	.	NNP
cord-316996-8yimrpaz	125	55	,	,	,
cord-316996-8yimrpaz	125	56	2008	2008	CD
cord-316996-8yimrpaz	125	57	)	)	-RRB-
cord-316996-8yimrpaz	125	58	.	.	.
cord-316996-8yimrpaz	126	1	Although	although	IN
cord-316996-8yimrpaz	126	2	sequence	sequence	NN
cord-316996-8yimrpaz	126	3	homologies	homology	NNS
cord-316996-8yimrpaz	126	4	among	among	IN
cord-316996-8yimrpaz	126	5	the	the	DT
cord-316996-8yimrpaz	126	6	different	different	JJ
cord-316996-8yimrpaz	126	7	bacterial	bacterial	JJ
cord-316996-8yimrpaz	126	8	sialidases	sialidase	NNS
cord-316996-8yimrpaz	126	9	are	be	VBP
cord-316996-8yimrpaz	126	10	less	less	JJR
cord-316996-8yimrpaz	126	11	than	than	IN
cord-316996-8yimrpaz	126	12	30	30	CD
cord-316996-8yimrpaz	126	13	%	%	NN
cord-316996-8yimrpaz	126	14	,	,	,
cord-316996-8yimrpaz	126	15	there	there	EX
cord-316996-8yimrpaz	126	16	are	be	VBP
cord-316996-8yimrpaz	126	17	unique	unique	JJ
cord-316996-8yimrpaz	126	18	motifs	motif	NNS
cord-316996-8yimrpaz	126	19	and	and	CC
cord-316996-8yimrpaz	126	20	conserved	conserve	VBN
cord-316996-8yimrpaz	126	21	regions	region	NNS
cord-316996-8yimrpaz	126	22	in	in	IN
cord-316996-8yimrpaz	126	23	the	the	DT
cord-316996-8yimrpaz	126	24	sialidase	sialidase	NN
cord-316996-8yimrpaz	126	25	domains	domain	NNS
cord-316996-8yimrpaz	126	26	.	.	.
cord-316996-8yimrpaz	127	1	The	the	DT
cord-316996-8yimrpaz	127	2	catalytic	catalytic	JJ
cord-316996-8yimrpaz	127	3	domain	domain	NN
cord-316996-8yimrpaz	127	4	of	of	IN
cord-316996-8yimrpaz	127	5	Clostridium	clostridium	NN
cord-316996-8yimrpaz	127	6	perfringens	perfringen	NNS
cord-316996-8yimrpaz	127	7	sialidase	sialidase	NN
cord-316996-8yimrpaz	127	8	has	have	VBZ
cord-316996-8yimrpaz	127	9	been	be	VBN
cord-316996-8yimrpaz	127	10	determined	determine	VBN
cord-316996-8yimrpaz	127	11	by	by	IN
cord-316996-8yimrpaz	127	12	NMR	NMR	NNP
cord-316996-8yimrpaz	127	13	,	,	,
cord-316996-8yimrpaz	127	14	and	and	CC
cord-316996-8yimrpaz	127	15	shares	share	NNS
cord-316996-8yimrpaz	127	16	key	key	JJ
cord-316996-8yimrpaz	127	17	features	feature	VBZ
cord-316996-8yimrpaz	127	18	with	with	IN
cord-316996-8yimrpaz	127	19	other	other	JJ
cord-316996-8yimrpaz	127	20	bacterial	bacterial	JJ
cord-316996-8yimrpaz	127	21	sialidases	sialidase	NNS
cord-316996-8yimrpaz	127	22	(	(	-LRB-
cord-316996-8yimrpaz	127	23	Newstead	Newstead	NNP
cord-316996-8yimrpaz	127	24	et	et	NNP
cord-316996-8yimrpaz	127	25	al	al	NNP
cord-316996-8yimrpaz	127	26	.	.	NNP
cord-316996-8yimrpaz	127	27	,	,	,
cord-316996-8yimrpaz	127	28	2008	2008	CD
cord-316996-8yimrpaz	127	29	)	)	-RRB-
cord-316996-8yimrpaz	127	30	.	.	.
cord-316996-8yimrpaz	128	1	These	these	DT
cord-316996-8yimrpaz	128	2	include	include	VBP
cord-316996-8yimrpaz	128	3	a	a	DT
cord-316996-8yimrpaz	128	4	cluster	cluster	NN
cord-316996-8yimrpaz	128	5	of	of	IN
cord-316996-8yimrpaz	128	6	three	three	CD
cord-316996-8yimrpaz	128	7	arginines	arginine	NNS
cord-316996-8yimrpaz	128	8	that	that	WDT
cord-316996-8yimrpaz	128	9	interact	interact	VBP
cord-316996-8yimrpaz	128	10	with	with	IN
cord-316996-8yimrpaz	128	11	the	the	DT
cord-316996-8yimrpaz	128	12	carboxylate	carboxylate	NNP
cord-316996-8yimrpaz	128	13	of	of	IN
cord-316996-8yimrpaz	128	14	C1	C1	NNP
cord-316996-8yimrpaz	128	15	,	,	,
cord-316996-8yimrpaz	128	16	an	an	DT
cord-316996-8yimrpaz	128	17	acid	acid	NN
cord-316996-8yimrpaz	128	18	/	/	SYM
cord-316996-8yimrpaz	128	19	base	base	NN
cord-316996-8yimrpaz	128	20	catabolic	catabolic	JJ
cord-316996-8yimrpaz	128	21	Asp	Asp	NNP
cord-316996-8yimrpaz	128	22	and	and	CC
cord-316996-8yimrpaz	128	23	a	a	DT
cord-316996-8yimrpaz	128	24	hydrophobic	hydrophobic	JJ
cord-316996-8yimrpaz	128	25	pocket	pocket	NN
cord-316996-8yimrpaz	128	26	to	to	TO
cord-316996-8yimrpaz	128	27	accommodate	accommodate	VB
cord-316996-8yimrpaz	128	28	the	the	DT
cord-316996-8yimrpaz	128	29	N	N	NNP
cord-316996-8yimrpaz	128	30	-	-	HYPH
cord-316996-8yimrpaz	128	31	acetyl	acetyl	NNP
cord-316996-8yimrpaz	128	32	group	group	NN
cord-316996-8yimrpaz	128	33	.	.	.
cord-316996-8yimrpaz	129	1	Three	three	CD
cord-316996-8yimrpaz	129	2	water	water	NN
cord-316996-8yimrpaz	129	3	molecules	molecule	NNS
cord-316996-8yimrpaz	129	4	are	be	VBP
cord-316996-8yimrpaz	129	5	involved	involve	VBN
cord-316996-8yimrpaz	129	6	to	to	TO
cord-316996-8yimrpaz	129	7	bridge	bridge	VB
cord-316996-8yimrpaz	129	8	the	the	DT
cord-316996-8yimrpaz	129	9	side	side	NN
cord-316996-8yimrpaz	129	10	chains	chain	NNS
cord-316996-8yimrpaz	129	11	and	and	CC
cord-316996-8yimrpaz	129	12	ligands	ligand	NNS
cord-316996-8yimrpaz	129	13	.	.	.
cord-316996-8yimrpaz	130	1	Despite	despite	IN
cord-316996-8yimrpaz	130	2	many	many	JJ
cord-316996-8yimrpaz	130	3	overall	overall	JJ
cord-316996-8yimrpaz	130	4	similarities	similarity	NNS
cord-316996-8yimrpaz	130	5	in	in	IN
cord-316996-8yimrpaz	130	6	structure	structure	NN
cord-316996-8yimrpaz	130	7	,	,	,
cord-316996-8yimrpaz	130	8	each	each	DT
cord-316996-8yimrpaz	130	9	bacterial	bacterial	JJ
cord-316996-8yimrpaz	130	10	sialidase	sialidase	NN
cord-316996-8yimrpaz	130	11	displays	display	VBZ
cord-316996-8yimrpaz	130	12	a	a	DT
cord-316996-8yimrpaz	130	13	preference	preference	NN
cord-316996-8yimrpaz	130	14	for	for	IN
cord-316996-8yimrpaz	130	15	a	a	DT
cord-316996-8yimrpaz	130	16	different	different	JJ
cord-316996-8yimrpaz	130	17	linkage	linkage	NN
cord-316996-8yimrpaz	130	18	,	,	,
cord-316996-8yimrpaz	130	19	in	in	IN
cord-316996-8yimrpaz	130	20	a	a	DT
cord-316996-8yimrpaz	130	21	manner	manner	NN
cord-316996-8yimrpaz	130	22	that	that	WDT
cord-316996-8yimrpaz	130	23	is	be	VBZ
cord-316996-8yimrpaz	130	24	not	not	RB
cord-316996-8yimrpaz	130	25	clearly	clearly	RB
cord-316996-8yimrpaz	130	26	related	relate	VBN
cord-316996-8yimrpaz	130	27	to	to	IN
cord-316996-8yimrpaz	130	28	the	the	DT
cord-316996-8yimrpaz	130	29	bacterial	bacterial	JJ
cord-316996-8yimrpaz	130	30	species	specie	NNS
cord-316996-8yimrpaz	130	31	.	.	.
cord-316996-8yimrpaz	131	1	The	the	DT
cord-316996-8yimrpaz	131	2	range	range	NN
cord-316996-8yimrpaz	131	3	and	and	CC
cord-316996-8yimrpaz	131	4	diversity	diversity	NN
cord-316996-8yimrpaz	131	5	of	of	IN
cord-316996-8yimrpaz	131	6	bacterial	bacterial	JJ
cord-316996-8yimrpaz	131	7	sialidase	sialidase	NN
cord-316996-8yimrpaz	131	8	specificities	specificity	NNS
cord-316996-8yimrpaz	131	9	was	be	VBD
cord-316996-8yimrpaz	131	10	initially	initially	RB
cord-316996-8yimrpaz	131	11	studied	study	VBN
cord-316996-8yimrpaz	131	12	and	and	CC
cord-316996-8yimrpaz	131	13	characterized	characterize	VBN
cord-316996-8yimrpaz	131	14	by	by	IN
cord-316996-8yimrpaz	131	15	Schauer	Schauer	NNP
cord-316996-8yimrpaz	131	16	in	in	IN
cord-316996-8yimrpaz	131	17	the	the	DT
cord-316996-8yimrpaz	131	18	early	early	JJ
cord-316996-8yimrpaz	131	19	1980s	1980	NNS
cord-316996-8yimrpaz	131	20	(	(	-LRB-
cord-316996-8yimrpaz	131	21	Corfield	Corfield	NNP
cord-316996-8yimrpaz	131	22	et	et	NNP
cord-316996-8yimrpaz	131	23	al	al	NNP
cord-316996-8yimrpaz	131	24	.	.	NNP
cord-316996-8yimrpaz	131	25	,	,	,
cord-316996-8yimrpaz	131	26	1981	1981	CD
cord-316996-8yimrpaz	131	27	;	;	:
cord-316996-8yimrpaz	131	28	Corfield	Corfield	NNP
cord-316996-8yimrpaz	131	29	et	et	NNP
cord-316996-8yimrpaz	131	30	al	al	NNP
cord-316996-8yimrpaz	131	31	.	.	NNP
cord-316996-8yimrpaz	131	32	,	,	,
cord-316996-8yimrpaz	131	33	1983	1983	CD
cord-316996-8yimrpaz	131	34	)	)	-RRB-
cord-316996-8yimrpaz	131	35	.	.	.
cord-316996-8yimrpaz	132	1	For	for	IN
cord-316996-8yimrpaz	132	2	instance	instance	NN
cord-316996-8yimrpaz	132	3	,	,	,
cord-316996-8yimrpaz	132	4	Bacteroides	Bacteroides	NNP
cord-316996-8yimrpaz	132	5	fragilis	fragili	NNS
cord-316996-8yimrpaz	133	1	STB3182	STB3182	NNP
cord-316996-8yimrpaz	133	2	prefers	prefer	VBZ
cord-316996-8yimrpaz	133	3	the	the	DT
cord-316996-8yimrpaz	133	4	a2	a2	NNP
cord-316996-8yimrpaz	133	5	-	-	HYPH
cord-316996-8yimrpaz	133	6	8	8	CD
cord-316996-8yimrpaz	133	7	to	to	IN
cord-316996-8yimrpaz	133	8	the	the	DT
cord-316996-8yimrpaz	133	9	a2	a2	NN
cord-316996-8yimrpaz	133	10	-	-	HYPH
cord-316996-8yimrpaz	133	11	3/6	3/6	CD
cord-316996-8yimrpaz	133	12	linkage	linkage	NN
cord-316996-8yimrpaz	133	13	,	,	,
cord-316996-8yimrpaz	133	14	but	but	CC
cord-316996-8yimrpaz	133	15	B.	B.	NNP
cord-316996-8yimrpaz	133	16	fragilis	fragilis	NN
cord-316996-8yimrpaz	133	17	4852	4852	CD
cord-316996-8yimrpaz	133	18	appears	appear	VBZ
cord-316996-8yimrpaz	133	19	quite	quite	RB
cord-316996-8yimrpaz	133	20	flexible	flexible	JJ
cord-316996-8yimrpaz	133	21	in	in	IN
cord-316996-8yimrpaz	133	22	its	-PRON-	PRP$
cord-316996-8yimrpaz	133	23	preference	preference	NN
cord-316996-8yimrpaz	133	24	.	.	.
cord-316996-8yimrpaz	134	1	It	-PRON-	PRP
cord-316996-8yimrpaz	134	2	is	be	VBZ
cord-316996-8yimrpaz	134	3	even	even	RB
cord-316996-8yimrpaz	134	4	possible	possible	JJ
cord-316996-8yimrpaz	134	5	for	for	IN
cord-316996-8yimrpaz	134	6	the	the	DT
cord-316996-8yimrpaz	134	7	same	same	JJ
cord-316996-8yimrpaz	134	8	bacteria	bacteria	NNS
cord-316996-8yimrpaz	134	9	to	to	TO
cord-316996-8yimrpaz	134	10	have	have	VB
cord-316996-8yimrpaz	134	11	different	different	JJ
cord-316996-8yimrpaz	134	12	specificities	specificity	NNS
cord-316996-8yimrpaz	134	13	:	:	:
cord-316996-8yimrpaz	135	1	the	the	DT
cord-316996-8yimrpaz	135	2	NanA	NanA	NNP
cord-316996-8yimrpaz	135	3	of	of	IN
cord-316996-8yimrpaz	135	4	S.	S.	NNP
cord-316996-8yimrpaz	135	5	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	135	6	can	can	MD
cord-316996-8yimrpaz	135	7	cleave	cleave	VB
cord-316996-8yimrpaz	135	8	a2	a2	NNP
cord-316996-8yimrpaz	135	9	-	-	HYPH
cord-316996-8yimrpaz	135	10	3	3	CD
cord-316996-8yimrpaz	135	11	,	,	,
cord-316996-8yimrpaz	135	12	a2	a2	NNP
cord-316996-8yimrpaz	135	13	-	-	HYPH
cord-316996-8yimrpaz	135	14	6	6	CD
cord-316996-8yimrpaz	135	15	or	or	CC
cord-316996-8yimrpaz	135	16	a2	a2	NNP
cord-316996-8yimrpaz	135	17	-	-	HYPH
cord-316996-8yimrpaz	135	18	8	8	CD
cord-316996-8yimrpaz	135	19	linkages	linkage	NNS
cord-316996-8yimrpaz	135	20	,	,	,
cord-316996-8yimrpaz	135	21	but	but	CC
cord-316996-8yimrpaz	135	22	the	the	DT
cord-316996-8yimrpaz	135	23	extracellular	extracellular	JJ
cord-316996-8yimrpaz	135	24	NanB	NanB	NNP
cord-316996-8yimrpaz	135	25	prefers	prefer	VBZ
cord-316996-8yimrpaz	135	26	a	a	DT
cord-316996-8yimrpaz	135	27	substrate	substrate	NN
cord-316996-8yimrpaz	135	28	with	with	IN
cord-316996-8yimrpaz	135	29	the	the	DT
cord-316996-8yimrpaz	135	30	a2	a2	NN
cord-316996-8yimrpaz	135	31	-	-	HYPH
cord-316996-8yimrpaz	135	32	3	3	CD
cord-316996-8yimrpaz	135	33	linkage	linkage	NN
cord-316996-8yimrpaz	135	34	.	.	.
cord-316996-8yimrpaz	136	1	The	the	DT
cord-316996-8yimrpaz	136	2	broad	broad	JJ
cord-316996-8yimrpaz	136	3	range	range	NN
cord-316996-8yimrpaz	136	4	of	of	IN
cord-316996-8yimrpaz	136	5	specificities	specificity	NNS
cord-316996-8yimrpaz	136	6	has	have	VBZ
cord-316996-8yimrpaz	136	7	been	be	VBN
cord-316996-8yimrpaz	136	8	attributed	attribute	VBN
cord-316996-8yimrpaz	136	9	to	to	IN
cord-316996-8yimrpaz	136	10	a	a	DT
cord-316996-8yimrpaz	136	11	number	number	NN
cord-316996-8yimrpaz	136	12	of	of	IN
cord-316996-8yimrpaz	136	13	mechanisms	mechanism	NNS
cord-316996-8yimrpaz	136	14	,	,	,
cord-316996-8yimrpaz	136	15	including	include	VBG
cord-316996-8yimrpaz	136	16	the	the	DT
cord-316996-8yimrpaz	136	17	configuration	configuration	NN
cord-316996-8yimrpaz	136	18	of	of	IN
cord-316996-8yimrpaz	136	19	the	the	DT
cord-316996-8yimrpaz	136	20	active	active	JJ
cord-316996-8yimrpaz	136	21	site	site	NN
cord-316996-8yimrpaz	136	22	and	and	CC
cord-316996-8yimrpaz	136	23	the	the	DT
cord-316996-8yimrpaz	136	24	role	role	NN
cord-316996-8yimrpaz	136	25	of	of	IN
cord-316996-8yimrpaz	136	26	water	water	NN
cord-316996-8yimrpaz	136	27	molecules	molecule	NNS
cord-316996-8yimrpaz	136	28	as	as	IN
cord-316996-8yimrpaz	136	29	nucleophiles	nucleophile	NNS
cord-316996-8yimrpaz	136	30	.	.	.
cord-316996-8yimrpaz	137	1	The	the	DT
cord-316996-8yimrpaz	137	2	crystal	crystal	JJ
cord-316996-8yimrpaz	137	3	structure	structure	NN
cord-316996-8yimrpaz	137	4	of	of	IN
cord-316996-8yimrpaz	137	5	NanB	NanB	NNP
cord-316996-8yimrpaz	137	6	has	have	VBZ
cord-316996-8yimrpaz	137	7	been	be	VBN
cord-316996-8yimrpaz	137	8	used	use	VBN
cord-316996-8yimrpaz	137	9	to	to	TO
cord-316996-8yimrpaz	137	10	demonstrate	demonstrate	VB
cord-316996-8yimrpaz	137	11	a2	a2	NN
cord-316996-8yimrpaz	137	12	-	-	HYPH
cord-316996-8yimrpaz	137	13	3	3	CD
cord-316996-8yimrpaz	137	14	cleavage	cleavage	NN
cord-316996-8yimrpaz	137	15	specificity	specificity	NN
cord-316996-8yimrpaz	137	16	,	,	,
cord-316996-8yimrpaz	137	17	proposing	propose	VBG
cord-316996-8yimrpaz	137	18	that	that	IN
cord-316996-8yimrpaz	137	19	an	an	DT
cord-316996-8yimrpaz	137	20	additional	additional	JJ
cord-316996-8yimrpaz	137	21	rim	rim	NN
cord-316996-8yimrpaz	137	22	of	of	IN
cord-316996-8yimrpaz	137	23	residues	residue	NNS
cord-316996-8yimrpaz	137	24	above	above	IN
cord-316996-8yimrpaz	137	25	the	the	DT
cord-316996-8yimrpaz	137	26	arginine	arginine	NN
cord-316996-8yimrpaz	137	27	triad	triad	NN
cord-316996-8yimrpaz	137	28	may	may	MD
cord-316996-8yimrpaz	137	29	only	only	RB
cord-316996-8yimrpaz	137	30	allow	allow	VB
cord-316996-8yimrpaz	137	31	an	an	DT
cord-316996-8yimrpaz	137	32	a2	a2	NN
cord-316996-8yimrpaz	137	33	-	-	HYPH
cord-316996-8yimrpaz	137	34	3	3	CD
cord-316996-8yimrpaz	137	35	configuration	configuration	NN
cord-316996-8yimrpaz	137	36	to	to	TO
cord-316996-8yimrpaz	137	37	bind	bind	VB
cord-316996-8yimrpaz	137	38	(	(	-LRB-
cord-316996-8yimrpaz	137	39	Gut	Gut	NNP
cord-316996-8yimrpaz	137	40	et	et	FW
cord-316996-8yimrpaz	137	41	al	al	NNP
cord-316996-8yimrpaz	137	42	.	.	NNP
cord-316996-8yimrpaz	137	43	,	,	,
cord-316996-8yimrpaz	137	44	2008	2008	CD
cord-316996-8yimrpaz	137	45	)	)	-RRB-
cord-316996-8yimrpaz	137	46	.	.	.
cord-316996-8yimrpaz	138	1	Because	because	IN
cord-316996-8yimrpaz	138	2	Sia	Sia	NNP
cord-316996-8yimrpaz	138	3	are	be	VBP
cord-316996-8yimrpaz	138	4	the	the	DT
cord-316996-8yimrpaz	138	5	primary	primary	JJ
cord-316996-8yimrpaz	138	6	recognition	recognition	NN
cord-316996-8yimrpaz	138	7	sites	site	NNS
cord-316996-8yimrpaz	138	8	for	for	IN
cord-316996-8yimrpaz	138	9	many	many	JJ
cord-316996-8yimrpaz	138	10	viral	viral	JJ
cord-316996-8yimrpaz	138	11	respiratory	respiratory	JJ
cord-316996-8yimrpaz	138	12	pathogens	pathogen	NNS
cord-316996-8yimrpaz	138	13	,	,	,
cord-316996-8yimrpaz	138	14	it	-PRON-	PRP
cord-316996-8yimrpaz	138	15	would	would	MD
cord-316996-8yimrpaz	138	16	seem	seem	VB
cord-316996-8yimrpaz	138	17	appropriate	appropriate	JJ
cord-316996-8yimrpaz	138	18	that	that	IN
cord-316996-8yimrpaz	138	19	a	a	DT
cord-316996-8yimrpaz	138	20	bacterial	bacterial	JJ
cord-316996-8yimrpaz	138	21	sialidase	sialidase	NN
cord-316996-8yimrpaz	138	22	could	could	MD
cord-316996-8yimrpaz	138	23	be	be	VB
cord-316996-8yimrpaz	138	24	used	use	VBN
cord-316996-8yimrpaz	138	25	as	as	IN
cord-316996-8yimrpaz	138	26	an	an	DT
cord-316996-8yimrpaz	138	27	inhibitory	inhibitory	JJ
cord-316996-8yimrpaz	138	28	agent	agent	NN
cord-316996-8yimrpaz	138	29	to	to	TO
cord-316996-8yimrpaz	138	30	cleave	cleave	VB
cord-316996-8yimrpaz	138	31	Sia	Sia	NNP
cord-316996-8yimrpaz	138	32	from	from	IN
cord-316996-8yimrpaz	138	33	the	the	DT
cord-316996-8yimrpaz	138	34	surface	surface	NN
cord-316996-8yimrpaz	138	35	receptor	receptor	NN
cord-316996-8yimrpaz	138	36	,	,	,
cord-316996-8yimrpaz	138	37	and	and	CC
cord-316996-8yimrpaz	138	38	thus	thus	RB
cord-316996-8yimrpaz	138	39	block	block	NN
cord-316996-8yimrpaz	138	40	binding	binding	NN
cord-316996-8yimrpaz	138	41	.	.	.
cord-316996-8yimrpaz	139	1	Achieving	achieve	VBG
cord-316996-8yimrpaz	139	2	this	this	DT
cord-316996-8yimrpaz	139	3	would	would	MD
cord-316996-8yimrpaz	139	4	require	require	VB
cord-316996-8yimrpaz	139	5	a	a	DT
cord-316996-8yimrpaz	139	6	number	number	NN
cord-316996-8yimrpaz	139	7	of	of	IN
cord-316996-8yimrpaz	139	8	properties	property	NNS
cord-316996-8yimrpaz	139	9	.	.	.
cord-316996-8yimrpaz	140	1	The	the	DT
cord-316996-8yimrpaz	140	2	first	first	JJ
cord-316996-8yimrpaz	140	3	is	be	VBZ
cord-316996-8yimrpaz	140	4	that	that	IN
cord-316996-8yimrpaz	140	5	an	an	DT
cord-316996-8yimrpaz	140	6	effective	effective	JJ
cord-316996-8yimrpaz	140	7	sialidase	sialidase	NN
cord-316996-8yimrpaz	140	8	would	would	MD
cord-316996-8yimrpaz	140	9	need	need	VB
cord-316996-8yimrpaz	140	10	to	to	TO
cord-316996-8yimrpaz	140	11	have	have	VB
cord-316996-8yimrpaz	140	12	a	a	DT
cord-316996-8yimrpaz	140	13	broad	broad	JJ
cord-316996-8yimrpaz	140	14	catalytic	catalytic	JJ
cord-316996-8yimrpaz	140	15	activity	activity	NN
cord-316996-8yimrpaz	140	16	,	,	,
cord-316996-8yimrpaz	140	17	because	because	IN
cord-316996-8yimrpaz	140	18	with	with	IN
cord-316996-8yimrpaz	140	19	agents	agent	NNS
cord-316996-8yimrpaz	140	20	such	such	JJ
cord-316996-8yimrpaz	140	21	as	as	IN
cord-316996-8yimrpaz	140	22	influenza	influenza	NN
cord-316996-8yimrpaz	140	23	virus	virus	NN
cord-316996-8yimrpaz	140	24	,	,	,
cord-316996-8yimrpaz	140	25	binding	bind	VBG
cord-316996-8yimrpaz	140	26	is	be	VBZ
cord-316996-8yimrpaz	140	27	dependent	dependent	JJ
cord-316996-8yimrpaz	140	28	on	on	IN
cord-316996-8yimrpaz	140	29	the	the	DT
cord-316996-8yimrpaz	140	30	linkage	linkage	NN
cord-316996-8yimrpaz	140	31	between	between	IN
cord-316996-8yimrpaz	140	32	the	the	DT
cord-316996-8yimrpaz	140	33	Sia	Sia	NNP
cord-316996-8yimrpaz	140	34	and	and	CC
cord-316996-8yimrpaz	140	35	galactose	galactose	NN
cord-316996-8yimrpaz	140	36	.	.	.
cord-316996-8yimrpaz	141	1	The	the	DT
cord-316996-8yimrpaz	141	2	first	first	JJ
cord-316996-8yimrpaz	141	3	evidence	evidence	NN
cord-316996-8yimrpaz	141	4	of	of	IN
cord-316996-8yimrpaz	141	5	this	this	DT
cord-316996-8yimrpaz	141	6	in	in	IN
cord-316996-8yimrpaz	141	7	influenza	influenza	NN
cord-316996-8yimrpaz	141	8	was	be	VBD
cord-316996-8yimrpaz	141	9	demonstrated	demonstrate	VBN
cord-316996-8yimrpaz	141	10	by	by	IN
cord-316996-8yimrpaz	141	11	Rogers	Rogers	NNP
cord-316996-8yimrpaz	141	12	and	and	CC
cord-316996-8yimrpaz	141	13	Paulson	Paulson	NNP
cord-316996-8yimrpaz	141	14	,	,	,
cord-316996-8yimrpaz	141	15	who	who	WP
cord-316996-8yimrpaz	141	16	desialylated	desialylate	VBD
cord-316996-8yimrpaz	141	17	red	red	JJ
cord-316996-8yimrpaz	141	18	blood	blood	NN
cord-316996-8yimrpaz	141	19	cells	cell	NNS
cord-316996-8yimrpaz	141	20	,	,	,
cord-316996-8yimrpaz	141	21	then	then	RB
cord-316996-8yimrpaz	141	22	re	re	VB
cord-316996-8yimrpaz	141	23	-	-	VBN
cord-316996-8yimrpaz	141	24	sialylated	sialylate	VBD
cord-316996-8yimrpaz	141	25	them	-PRON-	PRP
cord-316996-8yimrpaz	141	26	using	use	VBG
cord-316996-8yimrpaz	141	27	specific	specific	JJ
cord-316996-8yimrpaz	141	28	sialyltransferases	sialyltransferase	NNS
cord-316996-8yimrpaz	141	29	that	that	WDT
cord-316996-8yimrpaz	141	30	were	be	VBD
cord-316996-8yimrpaz	141	31	either	either	CC
cord-316996-8yimrpaz	141	32	a2	a2	NN
cord-316996-8yimrpaz	141	33	-	-	HYPH
cord-316996-8yimrpaz	141	34	3	3	CD
cord-316996-8yimrpaz	141	35	or	or	CC
cord-316996-8yimrpaz	141	36	a2	a2	NNP
cord-316996-8yimrpaz	141	37	-	-	HYPH
cord-316996-8yimrpaz	141	38	6	6	CD
cord-316996-8yimrpaz	141	39	linked	link	VBN
cord-316996-8yimrpaz	141	40	.	.	.
cord-316996-8yimrpaz	142	1	Avian	avian	JJ
cord-316996-8yimrpaz	142	2	or	or	CC
cord-316996-8yimrpaz	142	3	equine	equine	JJ
cord-316996-8yimrpaz	142	4	viruses	virus	NNS
cord-316996-8yimrpaz	142	5	agglutinated	agglutinate	VBD
cord-316996-8yimrpaz	142	6	the	the	DT
cord-316996-8yimrpaz	142	7	former	former	JJ
cord-316996-8yimrpaz	142	8	,	,	,
cord-316996-8yimrpaz	142	9	while	while	IN
cord-316996-8yimrpaz	142	10	human	human	NN
cord-316996-8yimrpaz	142	11	and	and	CC
cord-316996-8yimrpaz	142	12	swine	swine	NN
cord-316996-8yimrpaz	142	13	viruses	virus	NNS
cord-316996-8yimrpaz	142	14	agglutinated	agglutinate	VBD
cord-316996-8yimrpaz	142	15	the	the	DT
cord-316996-8yimrpaz	142	16	latter	latter	JJ
cord-316996-8yimrpaz	142	17	.	.	.
cord-316996-8yimrpaz	143	1	From	from	IN
cord-316996-8yimrpaz	143	2	these	these	DT
cord-316996-8yimrpaz	143	3	studies	study	NNS
cord-316996-8yimrpaz	143	4	the	the	DT
cord-316996-8yimrpaz	143	5	paradigm	paradigm	NN
cord-316996-8yimrpaz	143	6	emerged	emerge	VBD
cord-316996-8yimrpaz	143	7	that	that	IN
cord-316996-8yimrpaz	143	8	avian	avian	JJ
cord-316996-8yimrpaz	143	9	viruses	virus	NNS
cord-316996-8yimrpaz	143	10	were	be	VBD
cord-316996-8yimrpaz	143	11	primarily	primarily	RB
cord-316996-8yimrpaz	144	1	a2	a2	NNP
cord-316996-8yimrpaz	144	2	-	-	HYPH
cord-316996-8yimrpaz	144	3	3	3	CD
cord-316996-8yimrpaz	144	4	binding	binding	NN
cord-316996-8yimrpaz	144	5	and	and	CC
cord-316996-8yimrpaz	144	6	human	human	NN
cord-316996-8yimrpaz	144	7	and	and	CC
cord-316996-8yimrpaz	144	8	swine	swine	NN
cord-316996-8yimrpaz	144	9	viruses	virus	NNS
cord-316996-8yimrpaz	144	10	were	be	VBD
cord-316996-8yimrpaz	144	11	a2	a2	NNP
cord-316996-8yimrpaz	144	12	-	-	HYPH
cord-316996-8yimrpaz	144	13	6	6	CD
cord-316996-8yimrpaz	144	14	binding	bind	VBG
cord-316996-8yimrpaz	144	15	(	(	-LRB-
cord-316996-8yimrpaz	144	16	Wilks	Wilks	NNP
cord-316996-8yimrpaz	144	17	et	et	NNP
cord-316996-8yimrpaz	144	18	al	al	NNP
cord-316996-8yimrpaz	144	19	.	.	NNP
cord-316996-8yimrpaz	144	20	,	,	,
cord-316996-8yimrpaz	144	21	2012	2012	CD
cord-316996-8yimrpaz	144	22	)	)	-RRB-
cord-316996-8yimrpaz	144	23	.	.	.
cord-316996-8yimrpaz	145	1	As	as	IN
cord-316996-8yimrpaz	145	2	ducks	duck	NNS
cord-316996-8yimrpaz	145	3	and	and	CC
cord-316996-8yimrpaz	145	4	waterfowl	waterfowl	NNS
cord-316996-8yimrpaz	145	5	contain	contain	VBP
cord-316996-8yimrpaz	145	6	mainly	mainly	RB
cord-316996-8yimrpaz	145	7	a2	a2	NNP
cord-316996-8yimrpaz	145	8	-	-	HYPH
cord-316996-8yimrpaz	145	9	3	3	CD
cord-316996-8yimrpaz	145	10	terminated	terminate	VBD
cord-316996-8yimrpaz	145	11	Sia	Sia	NNP
cord-316996-8yimrpaz	145	12	in	in	IN
cord-316996-8yimrpaz	145	13	their	-PRON-	PRP$
cord-316996-8yimrpaz	145	14	intestines	intestine	NNS
cord-316996-8yimrpaz	145	15	,	,	,
cord-316996-8yimrpaz	145	16	there	there	EX
cord-316996-8yimrpaz	145	17	would	would	MD
cord-316996-8yimrpaz	145	18	be	be	VB
cord-316996-8yimrpaz	145	19	little	little	JJ
cord-316996-8yimrpaz	145	20	selection	selection	NN
cord-316996-8yimrpaz	145	21	pressure	pressure	NN
cord-316996-8yimrpaz	145	22	for	for	IN
cord-316996-8yimrpaz	145	23	avian	avian	JJ
cord-316996-8yimrpaz	145	24	viruses	virus	NNS
cord-316996-8yimrpaz	145	25	to	to	TO
cord-316996-8yimrpaz	145	26	acquire	acquire	VB
cord-316996-8yimrpaz	145	27	a2	a2	NNP
cord-316996-8yimrpaz	145	28	-	-	HYPH
cord-316996-8yimrpaz	145	29	6	6	CD
cord-316996-8yimrpaz	145	30	binding	binding	NN
cord-316996-8yimrpaz	145	31	,	,	,
cord-316996-8yimrpaz	145	32	and	and	CC
cord-316996-8yimrpaz	145	33	cross	cross	JJ
cord-316996-8yimrpaz	145	34	-	-	JJ
cord-316996-8yimrpaz	145	35	species	species	JJ
cord-316996-8yimrpaz	145	36	transmission	transmission	NN
cord-316996-8yimrpaz	145	37	would	would	MD
cord-316996-8yimrpaz	145	38	require	require	VB
cord-316996-8yimrpaz	145	39	a	a	DT
cord-316996-8yimrpaz	145	40	number	number	NN
cord-316996-8yimrpaz	145	41	of	of	IN
cord-316996-8yimrpaz	145	42	mutations	mutation	NNS
cord-316996-8yimrpaz	145	43	.	.	.
cord-316996-8yimrpaz	146	1	In	in	IN
cord-316996-8yimrpaz	146	2	ferrets	ferret	NNS
cord-316996-8yimrpaz	146	3	,	,	,
cord-316996-8yimrpaz	146	4	for	for	IN
cord-316996-8yimrpaz	146	5	example	example	NN
cord-316996-8yimrpaz	146	6	,	,	,
cord-316996-8yimrpaz	146	7	up	up	IN
cord-316996-8yimrpaz	146	8	to	to	TO
cord-316996-8yimrpaz	146	9	nine	nine	CD
cord-316996-8yimrpaz	146	10	passages	passage	NNS
cord-316996-8yimrpaz	146	11	with	with	IN
cord-316996-8yimrpaz	146	12	a	a	DT
cord-316996-8yimrpaz	146	13	high	high	JJ
cord-316996-8yimrpaz	146	14	inoculum	inoculum	NN
cord-316996-8yimrpaz	146	15	has	have	VBZ
cord-316996-8yimrpaz	146	16	been	be	VBN
cord-316996-8yimrpaz	146	17	required	require	VBN
cord-316996-8yimrpaz	146	18	for	for	IN
cord-316996-8yimrpaz	146	19	adaptation	adaptation	NN
cord-316996-8yimrpaz	146	20	of	of	IN
cord-316996-8yimrpaz	146	21	an	an	DT
cord-316996-8yimrpaz	146	22	H9N2	H9N2	NNP
cord-316996-8yimrpaz	146	23	virus	virus	NN
cord-316996-8yimrpaz	146	24	to	to	IN
cord-316996-8yimrpaz	146	25	the	the	DT
cord-316996-8yimrpaz	146	26	avian	avian	JJ
cord-316996-8yimrpaz	146	27	configuration	configuration	NN
cord-316996-8yimrpaz	146	28	(	(	-LRB-
cord-316996-8yimrpaz	146	29	Sorrell	Sorrell	NNP
cord-316996-8yimrpaz	146	30	et	et	NNP
cord-316996-8yimrpaz	146	31	al	al	NNP
cord-316996-8yimrpaz	146	32	.	.	NNP
cord-316996-8yimrpaz	146	33	,	,	,
cord-316996-8yimrpaz	146	34	2009	2009	CD
cord-316996-8yimrpaz	146	35	)	)	-RRB-
cord-316996-8yimrpaz	146	36	.	.	.
cord-316996-8yimrpaz	147	1	Recent	recent	JJ
cord-316996-8yimrpaz	147	2	studies	study	NNS
cord-316996-8yimrpaz	147	3	in	in	IN
cord-316996-8yimrpaz	147	4	the	the	DT
cord-316996-8yimrpaz	147	5	USA	USA	NNP
cord-316996-8yimrpaz	147	6	(	(	-LRB-
cord-316996-8yimrpaz	147	7	Imai	Imai	NNP
cord-316996-8yimrpaz	147	8	et	et	NNP
cord-316996-8yimrpaz	147	9	al	al	NNP
cord-316996-8yimrpaz	147	10	.	.	NNP
cord-316996-8yimrpaz	147	11	,	,	,
cord-316996-8yimrpaz	147	12	2012	2012	CD
cord-316996-8yimrpaz	147	13	)	)	-RRB-
cord-316996-8yimrpaz	147	14	and	and	CC
cord-316996-8yimrpaz	147	15	the	the	DT
cord-316996-8yimrpaz	147	16	Netherlands	Netherlands	NNP
cord-316996-8yimrpaz	147	17	(	(	-LRB-
cord-316996-8yimrpaz	147	18	Herfst	Herfst	NNP
cord-316996-8yimrpaz	147	19	et	et	FW
cord-316996-8yimrpaz	147	20	al	al	NNP
cord-316996-8yimrpaz	147	21	.	.	NNP
cord-316996-8yimrpaz	147	22	,	,	,
cord-316996-8yimrpaz	147	23	2012	2012	CD
cord-316996-8yimrpaz	147	24	)	)	-RRB-
cord-316996-8yimrpaz	147	25	have	have	VBP
cord-316996-8yimrpaz	147	26	shown	show	VBN
cord-316996-8yimrpaz	147	27	that	that	IN
cord-316996-8yimrpaz	147	28	H5N1	H5N1	NNP
cord-316996-8yimrpaz	147	29	undergoes	undergo	VBZ
cord-316996-8yimrpaz	147	30	natural	natural	JJ
cord-316996-8yimrpaz	147	31	purifying	purifying	NN
cord-316996-8yimrpaz	147	32	or	or	CC
cord-316996-8yimrpaz	147	33	negative	negative	JJ
cord-316996-8yimrpaz	147	34	selection	selection	NN
cord-316996-8yimrpaz	147	35	,	,	,
cord-316996-8yimrpaz	147	36	rather	rather	RB
cord-316996-8yimrpaz	147	37	than	than	IN
cord-316996-8yimrpaz	147	38	a	a	DT
cord-316996-8yimrpaz	147	39	diversifying	diversify	VBG
cord-316996-8yimrpaz	147	40	positive	positive	JJ
cord-316996-8yimrpaz	147	41	selection	selection	NN
cord-316996-8yimrpaz	147	42	,	,	,
cord-316996-8yimrpaz	147	43	and	and	CC
cord-316996-8yimrpaz	147	44	that	that	IN
cord-316996-8yimrpaz	147	45	multiple	multiple	JJ
cord-316996-8yimrpaz	147	46	introduced	introduce	VBN
cord-316996-8yimrpaz	147	47	mutations	mutation	NNS
cord-316996-8yimrpaz	147	48	are	be	VBP
cord-316996-8yimrpaz	147	49	required	require	VBN
cord-316996-8yimrpaz	147	50	for	for	IN
cord-316996-8yimrpaz	147	51	avian	avian	JJ
cord-316996-8yimrpaz	147	52	viruses	virus	NNS
cord-316996-8yimrpaz	147	53	to	to	TO
cord-316996-8yimrpaz	147	54	develop	develop	VB
cord-316996-8yimrpaz	147	55	greater	great	JJR
cord-316996-8yimrpaz	147	56	affinity	affinity	NN
cord-316996-8yimrpaz	147	57	for	for	IN
cord-316996-8yimrpaz	147	58	a2	a2	NNP
cord-316996-8yimrpaz	147	59	-	-	HYPH
cord-316996-8yimrpaz	147	60	6	6	CD
cord-316996-8yimrpaz	147	61	receptors	receptor	NNS
cord-316996-8yimrpaz	147	62	and	and	CC
cord-316996-8yimrpaz	147	63	to	to	TO
cord-316996-8yimrpaz	147	64	replicate	replicate	VB
cord-316996-8yimrpaz	147	65	in	in	IN
cord-316996-8yimrpaz	147	66	the	the	DT
cord-316996-8yimrpaz	147	67	ferret	ferret	JJ
cord-316996-8yimrpaz	147	68	upper	upper	JJ
cord-316996-8yimrpaz	147	69	respiratory	respiratory	JJ
cord-316996-8yimrpaz	147	70	tract	tract	NN
cord-316996-8yimrpaz	147	71	,	,	,
cord-316996-8yimrpaz	147	72	leading	lead	VBG
cord-316996-8yimrpaz	147	73	to	to	IN
cord-316996-8yimrpaz	147	74	transmission	transmission	NN
cord-316996-8yimrpaz	147	75	.	.	.
cord-316996-8yimrpaz	148	1	Lectin	Lectin	NNP
cord-316996-8yimrpaz	148	2	binding	bind	VBG
cord-316996-8yimrpaz	148	3	studies	study	NNS
cord-316996-8yimrpaz	148	4	have	have	VBP
cord-316996-8yimrpaz	148	5	shown	show	VBN
cord-316996-8yimrpaz	148	6	that	that	IN
cord-316996-8yimrpaz	148	7	a2	a2	NNP
cord-316996-8yimrpaz	148	8	-	-	HYPH
cord-316996-8yimrpaz	148	9	6	6	CD
cord-316996-8yimrpaz	148	10	and	and	CC
cord-316996-8yimrpaz	148	11	a2	a2	NNP
cord-316996-8yimrpaz	148	12	-	-	HYPH
cord-316996-8yimrpaz	148	13	3	3	CD
cord-316996-8yimrpaz	148	14	N	n	NN
cord-316996-8yimrpaz	148	15	-	-	HYPH
cord-316996-8yimrpaz	148	16	linked	link	VBN
cord-316996-8yimrpaz	148	17	sialic	sialic	JJ
cord-316996-8yimrpaz	148	18	acids	acid	NNS
cord-316996-8yimrpaz	148	19	are	be	VBP
cord-316996-8yimrpaz	148	20	distributed	distribute	VBN
cord-316996-8yimrpaz	148	21	throughout	throughout	IN
cord-316996-8yimrpaz	148	22	the	the	DT
cord-316996-8yimrpaz	148	23	upper	upper	JJ
cord-316996-8yimrpaz	148	24	and	and	CC
cord-316996-8yimrpaz	148	25	lower	low	JJR
cord-316996-8yimrpaz	148	26	respiratory	respiratory	JJ
cord-316996-8yimrpaz	148	27	tract	tract	NN
cord-316996-8yimrpaz	148	28	in	in	IN
cord-316996-8yimrpaz	148	29	humans	human	NNS
cord-316996-8yimrpaz	148	30	,	,	,
cord-316996-8yimrpaz	148	31	with	with	IN
cord-316996-8yimrpaz	148	32	an	an	DT
cord-316996-8yimrpaz	148	33	increased	increase	VBN
cord-316996-8yimrpaz	148	34	distribution	distribution	NN
cord-316996-8yimrpaz	148	35	of	of	IN
cord-316996-8yimrpaz	148	36	a2	a2	NN
cord-316996-8yimrpaz	148	37	-	-	HYPH
cord-316996-8yimrpaz	148	38	3	3	CD
cord-316996-8yimrpaz	148	39	O	o	NN
cord-316996-8yimrpaz	148	40	-	-	HYPH
cord-316996-8yimrpaz	148	41	linked	link	VBN
cord-316996-8yimrpaz	148	42	sialic	sialic	JJ
cord-316996-8yimrpaz	148	43	acids	acid	NNS
cord-316996-8yimrpaz	148	44	in	in	IN
cord-316996-8yimrpaz	148	45	the	the	DT
cord-316996-8yimrpaz	148	46	lower	low	JJR
cord-316996-8yimrpaz	148	47	respiratory	respiratory	JJ
cord-316996-8yimrpaz	148	48	tract	tract	NN
cord-316996-8yimrpaz	148	49	(	(	-LRB-
cord-316996-8yimrpaz	148	50	Nicholls	Nicholls	NNP
cord-316996-8yimrpaz	148	51	et	et	NNP
cord-316996-8yimrpaz	148	52	al	al	NNP
cord-316996-8yimrpaz	148	53	.	.	NNP
cord-316996-8yimrpaz	148	54	,	,	,
cord-316996-8yimrpaz	148	55	2007	2007	CD
cord-316996-8yimrpaz	148	56	)	)	-RRB-
cord-316996-8yimrpaz	148	57	.	.	.
cord-316996-8yimrpaz	149	1	If	if	IN
cord-316996-8yimrpaz	149	2	a	a	DT
cord-316996-8yimrpaz	149	3	sialidase	sialidase	NN
cord-316996-8yimrpaz	149	4	was	be	VBD
cord-316996-8yimrpaz	149	5	to	to	TO
cord-316996-8yimrpaz	149	6	be	be	VB
cord-316996-8yimrpaz	149	7	used	use	VBN
cord-316996-8yimrpaz	149	8	to	to	TO
cord-316996-8yimrpaz	149	9	prevent	prevent	VB
cord-316996-8yimrpaz	149	10	influenza	influenza	NN
cord-316996-8yimrpaz	149	11	in	in	IN
cord-316996-8yimrpaz	149	12	humans	human	NNS
cord-316996-8yimrpaz	149	13	,	,	,
cord-316996-8yimrpaz	149	14	it	-PRON-	PRP
cord-316996-8yimrpaz	149	15	would	would	MD
cord-316996-8yimrpaz	149	16	therefore	therefore	RB
cord-316996-8yimrpaz	149	17	have	have	VB
cord-316996-8yimrpaz	149	18	to	to	TO
cord-316996-8yimrpaz	149	19	be	be	VB
cord-316996-8yimrpaz	149	20	one	one	CD
cord-316996-8yimrpaz	149	21	that	that	WDT
cord-316996-8yimrpaz	149	22	cleaves	cleave	VBZ
cord-316996-8yimrpaz	149	23	both	both	DT
cord-316996-8yimrpaz	149	24	types	type	NNS
cord-316996-8yimrpaz	149	25	of	of	IN
cord-316996-8yimrpaz	149	26	linkages	linkage	NNS
cord-316996-8yimrpaz	149	27	present	present	JJ
cord-316996-8yimrpaz	149	28	in	in	IN
cord-316996-8yimrpaz	149	29	the	the	DT
cord-316996-8yimrpaz	149	30	upper	upper	JJ
cord-316996-8yimrpaz	149	31	and	and	CC
cord-316996-8yimrpaz	149	32	lower	low	JJR
cord-316996-8yimrpaz	149	33	airways	airway	NNS
cord-316996-8yimrpaz	149	34	.	.	.
cord-316996-8yimrpaz	150	1	To	to	TO
cord-316996-8yimrpaz	150	2	be	be	VB
cord-316996-8yimrpaz	150	3	used	use	VBN
cord-316996-8yimrpaz	150	4	as	as	IN
cord-316996-8yimrpaz	150	5	therapy	therapy	NN
cord-316996-8yimrpaz	150	6	for	for	IN
cord-316996-8yimrpaz	150	7	respiratory	respiratory	JJ
cord-316996-8yimrpaz	150	8	tract	tract	NN
cord-316996-8yimrpaz	150	9	infections	infection	NNS
cord-316996-8yimrpaz	150	10	,	,	,
cord-316996-8yimrpaz	150	11	a	a	DT
cord-316996-8yimrpaz	150	12	sialidase	sialidase	NN
cord-316996-8yimrpaz	150	13	also	also	RB
cord-316996-8yimrpaz	150	14	have	have	VBP
cord-316996-8yimrpaz	150	15	to	to	TO
cord-316996-8yimrpaz	150	16	be	be	VB
cord-316996-8yimrpaz	150	17	effective	effective	JJ
cord-316996-8yimrpaz	150	18	as	as	IN
cord-316996-8yimrpaz	150	19	a	a	DT
cord-316996-8yimrpaz	150	20	topical	topical	JJ
cord-316996-8yimrpaz	150	21	or	or	CC
cord-316996-8yimrpaz	150	22	inhalational	inhalational	JJ
cord-316996-8yimrpaz	150	23	agent	agent	NN
cord-316996-8yimrpaz	150	24	.	.	.
cord-316996-8yimrpaz	151	1	It	-PRON-	PRP
cord-316996-8yimrpaz	151	2	was	be	VBD
cord-316996-8yimrpaz	151	3	mentioned	mention	VBN
cord-316996-8yimrpaz	151	4	previously	previously	RB
cord-316996-8yimrpaz	151	5	that	that	IN
cord-316996-8yimrpaz	151	6	one	one	CD
cord-316996-8yimrpaz	151	7	of	of	IN
cord-316996-8yimrpaz	151	8	the	the	DT
cord-316996-8yimrpaz	151	9	properties	property	NNS
cord-316996-8yimrpaz	151	10	of	of	IN
cord-316996-8yimrpaz	151	11	Sia	Sia	NNP
cord-316996-8yimrpaz	151	12	is	be	VBZ
cord-316996-8yimrpaz	151	13	to	to	TO
cord-316996-8yimrpaz	151	14	protect	protect	VB
cord-316996-8yimrpaz	151	15	'	'	''
cord-316996-8yimrpaz	151	16	'	'	``
cord-316996-8yimrpaz	151	17	self	self	NN
cord-316996-8yimrpaz	151	18	'	'	''
cord-316996-8yimrpaz	151	19	'	'	''
cord-316996-8yimrpaz	151	20	glycoproteins	glycoprotein	NNS
cord-316996-8yimrpaz	151	21	from	from	IN
cord-316996-8yimrpaz	151	22	being	be	VBG
cord-316996-8yimrpaz	151	23	recognized	recognize	VBN
cord-316996-8yimrpaz	151	24	as	as	IN
cord-316996-8yimrpaz	151	25	'	'	''
cord-316996-8yimrpaz	151	26	'	'	``
cord-316996-8yimrpaz	151	27	foreign	foreign	JJ
cord-316996-8yimrpaz	151	28	'	'	''
cord-316996-8yimrpaz	151	29	'	'	''
cord-316996-8yimrpaz	151	30	.	.	.
cord-316996-8yimrpaz	152	1	If	if	IN
cord-316996-8yimrpaz	152	2	a	a	DT
cord-316996-8yimrpaz	152	3	sialidase	sialidase	NN
cord-316996-8yimrpaz	152	4	were	be	VBD
cord-316996-8yimrpaz	152	5	administered	administer	VBN
cord-316996-8yimrpaz	152	6	systemically	systemically	RB
cord-316996-8yimrpaz	152	7	,	,	,
cord-316996-8yimrpaz	152	8	this	this	DT
cord-316996-8yimrpaz	152	9	could	could	MD
cord-316996-8yimrpaz	152	10	lead	lead	VB
cord-316996-8yimrpaz	152	11	to	to	IN
cord-316996-8yimrpaz	152	12	widespread	widespread	JJ
cord-316996-8yimrpaz	152	13	desialylation	desialylation	NN
cord-316996-8yimrpaz	152	14	of	of	IN
cord-316996-8yimrpaz	152	15	glycoproteins	glycoprotein	NNS
cord-316996-8yimrpaz	152	16	and	and	CC
cord-316996-8yimrpaz	152	17	suppression	suppression	NN
cord-316996-8yimrpaz	152	18	of	of	IN
cord-316996-8yimrpaz	152	19	the	the	DT
cord-316996-8yimrpaz	152	20	Siglec	Siglec	NNP
cord-316996-8yimrpaz	152	21	pathways	pathway	NNS
cord-316996-8yimrpaz	152	22	.	.	.
cord-316996-8yimrpaz	153	1	For	for	IN
cord-316996-8yimrpaz	153	2	instance	instance	NN
cord-316996-8yimrpaz	153	3	,	,	,
cord-316996-8yimrpaz	153	4	since	since	IN
cord-316996-8yimrpaz	153	5	erythrocytes	erythrocyte	NNS
cord-316996-8yimrpaz	153	6	are	be	VBP
cord-316996-8yimrpaz	153	7	removed	remove	VBN
cord-316996-8yimrpaz	153	8	from	from	IN
cord-316996-8yimrpaz	153	9	the	the	DT
cord-316996-8yimrpaz	153	10	circulation	circulation	NN
cord-316996-8yimrpaz	153	11	once	once	IN
cord-316996-8yimrpaz	153	12	they	-PRON-	PRP
cord-316996-8yimrpaz	153	13	are	be	VBP
cord-316996-8yimrpaz	153	14	desialylated	desialylate	VBN
cord-316996-8yimrpaz	153	15	,	,	,
cord-316996-8yimrpaz	153	16	it	-PRON-	PRP
cord-316996-8yimrpaz	153	17	has	have	VBZ
cord-316996-8yimrpaz	153	18	been	be	VBN
cord-316996-8yimrpaz	153	19	proposed	propose	VBN
cord-316996-8yimrpaz	153	20	that	that	IN
cord-316996-8yimrpaz	153	21	systemic	systemic	JJ
cord-316996-8yimrpaz	153	22	sialidase	sialidase	NN
cord-316996-8yimrpaz	153	23	treatment	treatment	NN
cord-316996-8yimrpaz	153	24	might	may	MD
cord-316996-8yimrpaz	153	25	result	result	VB
cord-316996-8yimrpaz	153	26	in	in	IN
cord-316996-8yimrpaz	153	27	widespread	widespread	JJ
cord-316996-8yimrpaz	153	28	erythrophagocytosis	erythrophagocytosis	NN
cord-316996-8yimrpaz	153	29	(	(	-LRB-
cord-316996-8yimrpaz	153	30	Biondi	Biondi	NNP
cord-316996-8yimrpaz	153	31	et	et	NNP
cord-316996-8yimrpaz	153	32	al	al	NNP
cord-316996-8yimrpaz	153	33	.	.	NNP
cord-316996-8yimrpaz	153	34	,	,	,
cord-316996-8yimrpaz	153	35	2002	2002	CD
cord-316996-8yimrpaz	153	36	;	;	:
cord-316996-8yimrpaz	153	37	Bratosin	Bratosin	NNP
cord-316996-8yimrpaz	153	38	et	et	NNP
cord-316996-8yimrpaz	153	39	al	al	NNP
cord-316996-8yimrpaz	153	40	.	.	NNP
cord-316996-8yimrpaz	153	41	,	,	,
cord-316996-8yimrpaz	153	42	1998	1998	CD
cord-316996-8yimrpaz	153	43	)	)	-RRB-
cord-316996-8yimrpaz	153	44	.	.	.
cord-316996-8yimrpaz	154	1	Furthermore	furthermore	RB
cord-316996-8yimrpaz	154	2	,	,	,
cord-316996-8yimrpaz	154	3	as	as	IN
cord-316996-8yimrpaz	154	4	many	many	JJ
cord-316996-8yimrpaz	154	5	viral	viral	JJ
cord-316996-8yimrpaz	154	6	respiratory	respiratory	JJ
cord-316996-8yimrpaz	154	7	pathogens	pathogen	NNS
cord-316996-8yimrpaz	154	8	infect	infect	VBP
cord-316996-8yimrpaz	154	9	both	both	CC
cord-316996-8yimrpaz	154	10	the	the	DT
cord-316996-8yimrpaz	154	11	upper	upper	JJ
cord-316996-8yimrpaz	154	12	and	and	CC
cord-316996-8yimrpaz	154	13	lower	low	JJR
cord-316996-8yimrpaz	154	14	respiratory	respiratory	JJ
cord-316996-8yimrpaz	154	15	tract	tract	NN
cord-316996-8yimrpaz	154	16	,	,	,
cord-316996-8yimrpaz	154	17	including	include	VBG
cord-316996-8yimrpaz	154	18	the	the	DT
cord-316996-8yimrpaz	154	19	alveoli	alveolus	NNS
cord-316996-8yimrpaz	154	20	,	,	,
cord-316996-8yimrpaz	154	21	the	the	DT
cord-316996-8yimrpaz	154	22	sialidase	sialidase	NN
cord-316996-8yimrpaz	154	23	would	would	MD
cord-316996-8yimrpaz	154	24	need	need	VB
cord-316996-8yimrpaz	154	25	to	to	TO
cord-316996-8yimrpaz	154	26	be	be	VB
cord-316996-8yimrpaz	154	27	in	in	IN
cord-316996-8yimrpaz	154	28	an	an	DT
cord-316996-8yimrpaz	154	29	aerosolized	aerosolized	JJ
cord-316996-8yimrpaz	154	30	or	or	CC
cord-316996-8yimrpaz	154	31	nebulized	nebulize	VBN
cord-316996-8yimrpaz	154	32	form	form	NN
cord-316996-8yimrpaz	154	33	,	,	,
cord-316996-8yimrpaz	154	34	to	to	TO
cord-316996-8yimrpaz	154	35	allow	allow	VB
cord-316996-8yimrpaz	154	36	even	even	JJ
cord-316996-8yimrpaz	154	37	distribution	distribution	NN
cord-316996-8yimrpaz	154	38	throughout	throughout	IN
cord-316996-8yimrpaz	154	39	the	the	DT
cord-316996-8yimrpaz	154	40	airway	airway	NN
cord-316996-8yimrpaz	154	41	.	.	.
cord-316996-8yimrpaz	155	1	Finally	finally	RB
cord-316996-8yimrpaz	155	2	,	,	,
cord-316996-8yimrpaz	155	3	a	a	DT
cord-316996-8yimrpaz	155	4	mechanism	mechanism	NN
cord-316996-8yimrpaz	155	5	for	for	IN
cord-316996-8yimrpaz	155	6	retention	retention	NN
cord-316996-8yimrpaz	155	7	in	in	IN
cord-316996-8yimrpaz	155	8	the	the	DT
cord-316996-8yimrpaz	155	9	extracellular	extracellular	JJ
cord-316996-8yimrpaz	155	10	environment	environment	NN
cord-316996-8yimrpaz	155	11	,	,	,
cord-316996-8yimrpaz	155	12	avoiding	avoid	VBG
cord-316996-8yimrpaz	155	13	rapid	rapid	JJ
cord-316996-8yimrpaz	155	14	catabolism	catabolism	NN
cord-316996-8yimrpaz	155	15	,	,	,
cord-316996-8yimrpaz	155	16	would	would	MD
cord-316996-8yimrpaz	155	17	be	be	VB
cord-316996-8yimrpaz	155	18	advantageous	advantageous	JJ
cord-316996-8yimrpaz	155	19	for	for	IN
cord-316996-8yimrpaz	155	20	effective	effective	JJ
cord-316996-8yimrpaz	155	21	pharmacokinetics	pharmacokinetic	NNS
cord-316996-8yimrpaz	155	22	.	.	.
cord-316996-8yimrpaz	156	1	Sialidases	sialidase	NNS
cord-316996-8yimrpaz	156	2	have	have	VBP
cord-316996-8yimrpaz	156	3	been	be	VBN
cord-316996-8yimrpaz	156	4	demonstrated	demonstrate	VBN
cord-316996-8yimrpaz	156	5	to	to	TO
cord-316996-8yimrpaz	156	6	inhibit	inhibit	VB
cord-316996-8yimrpaz	156	7	influenza	influenza	NN
cord-316996-8yimrpaz	156	8	virus	virus	NN
cord-316996-8yimrpaz	156	9	infection	infection	NN
cord-316996-8yimrpaz	156	10	in	in	IN
cord-316996-8yimrpaz	156	11	a	a	DT
cord-316996-8yimrpaz	156	12	number	number	NN
cord-316996-8yimrpaz	156	13	of	of	IN
cord-316996-8yimrpaz	156	14	in	in	FW
cord-316996-8yimrpaz	156	15	vitro	vitro	FW
cord-316996-8yimrpaz	156	16	experiments	experiment	NNS
cord-316996-8yimrpaz	156	17	.	.	.
cord-316996-8yimrpaz	157	1	Even	even	RB
cord-316996-8yimrpaz	157	2	before	before	IN
cord-316996-8yimrpaz	157	3	Sia	Sia	NNP
cord-316996-8yimrpaz	157	4	were	be	VBD
cord-316996-8yimrpaz	157	5	proven	prove	VBN
cord-316996-8yimrpaz	157	6	to	to	TO
cord-316996-8yimrpaz	157	7	be	be	VB
cord-316996-8yimrpaz	157	8	the	the	DT
cord-316996-8yimrpaz	157	9	receptors	receptor	NNS
cord-316996-8yimrpaz	157	10	for	for	IN
cord-316996-8yimrpaz	157	11	influenza	influenza	NN
cord-316996-8yimrpaz	157	12	viruses	virus	NNS
cord-316996-8yimrpaz	157	13	,	,	,
cord-316996-8yimrpaz	157	14	it	-PRON-	PRP
cord-316996-8yimrpaz	157	15	was	be	VBD
cord-316996-8yimrpaz	157	16	observed	observe	VBN
cord-316996-8yimrpaz	157	17	that	that	IN
cord-316996-8yimrpaz	157	18	when	when	WRB
cord-316996-8yimrpaz	157	19	Sia	Sia	NNP
cord-316996-8yimrpaz	157	20	was	be	VBD
cord-316996-8yimrpaz	157	21	enzymatically	enzymatically	RB
cord-316996-8yimrpaz	157	22	removed	remove	VBN
cord-316996-8yimrpaz	157	23	from	from	IN
cord-316996-8yimrpaz	157	24	cell	cell	NN
cord-316996-8yimrpaz	157	25	surfaces	surface	NNS
cord-316996-8yimrpaz	157	26	,	,	,
cord-316996-8yimrpaz	157	27	the	the	DT
cord-316996-8yimrpaz	157	28	cells	cell	NNS
cord-316996-8yimrpaz	157	29	were	be	VBD
cord-316996-8yimrpaz	157	30	less	less	RBR
cord-316996-8yimrpaz	157	31	susceptible	susceptible	JJ
cord-316996-8yimrpaz	157	32	to	to	IN
cord-316996-8yimrpaz	157	33	infection	infection	NN
cord-316996-8yimrpaz	157	34	(	(	-LRB-
cord-316996-8yimrpaz	157	35	Gottschalk	Gottschalk	NNP
cord-316996-8yimrpaz	157	36	et	et	NNP
cord-316996-8yimrpaz	157	37	al	al	NNP
cord-316996-8yimrpaz	157	38	.	.	NNP
cord-316996-8yimrpaz	157	39	,	,	,
cord-316996-8yimrpaz	157	40	1960	1960	CD
cord-316996-8yimrpaz	157	41	)	)	-RRB-
cord-316996-8yimrpaz	157	42	.	.	.
cord-316996-8yimrpaz	158	1	Further	further	JJ
cord-316996-8yimrpaz	158	2	work	work	NN
cord-316996-8yimrpaz	158	3	using	use	VBG
cord-316996-8yimrpaz	158	4	bacterial	bacterial	JJ
cord-316996-8yimrpaz	158	5	sialidases	sialidase	NNS
cord-316996-8yimrpaz	158	6	and	and	CC
cord-316996-8yimrpaz	158	7	cell	cell	NN
cord-316996-8yimrpaz	158	8	lines	line	NNS
cord-316996-8yimrpaz	158	9	showed	show	VBD
cord-316996-8yimrpaz	158	10	a	a	DT
cord-316996-8yimrpaz	158	11	reduction	reduction	NN
cord-316996-8yimrpaz	158	12	in	in	IN
cord-316996-8yimrpaz	158	13	influenza	influenza	NN
cord-316996-8yimrpaz	158	14	virus	virus	NN
cord-316996-8yimrpaz	158	15	infection	infection	NN
cord-316996-8yimrpaz	158	16	(	(	-LRB-
cord-316996-8yimrpaz	158	17	Bergelson	Bergelson	NNP
cord-316996-8yimrpaz	158	18	et	et	NNP
cord-316996-8yimrpaz	158	19	al	al	NNP
cord-316996-8yimrpaz	158	20	.	.	NNP
cord-316996-8yimrpaz	158	21	,	,	,
cord-316996-8yimrpaz	158	22	1982	1982	CD
cord-316996-8yimrpaz	158	23	;	;	:
cord-316996-8yimrpaz	158	24	Griffin	Griffin	NNP
cord-316996-8yimrpaz	158	25	et	et	NNP
cord-316996-8yimrpaz	158	26	al	al	NNP
cord-316996-8yimrpaz	158	27	.	.	NNP
cord-316996-8yimrpaz	158	28	,	,	,
cord-316996-8yimrpaz	158	29	1983	1983	CD
cord-316996-8yimrpaz	158	30	)	)	-RRB-
cord-316996-8yimrpaz	158	31	.	.	.
cord-316996-8yimrpaz	159	1	The	the	DT
cord-316996-8yimrpaz	159	2	sialidase	sialidase	NN
cord-316996-8yimrpaz	159	3	of	of	IN
cord-316996-8yimrpaz	159	4	Micromonospora	Micromonospora	NNP
cord-316996-8yimrpaz	159	5	viridifaciens	viridifaciens	NNP
cord-316996-8yimrpaz	159	6	was	be	VBD
cord-316996-8yimrpaz	159	7	used	use	VBN
cord-316996-8yimrpaz	159	8	in	in	IN
cord-316996-8yimrpaz	159	9	1995	1995	CD
cord-316996-8yimrpaz	159	10	to	to	TO
cord-316996-8yimrpaz	159	11	destroy	destroy	VB
cord-316996-8yimrpaz	159	12	influenza	influenza	NN
cord-316996-8yimrpaz	159	13	receptors	receptor	NNS
cord-316996-8yimrpaz	159	14	(	(	-LRB-
cord-316996-8yimrpaz	159	15	Air	Air	NNP
cord-316996-8yimrpaz	159	16	and	and	CC
cord-316996-8yimrpaz	159	17	Laver	Laver	NNP
cord-316996-8yimrpaz	159	18	,	,	,
cord-316996-8yimrpaz	159	19	1995	1995	CD
cord-316996-8yimrpaz	159	20	)	)	-RRB-
cord-316996-8yimrpaz	159	21	but	but	CC
cord-316996-8yimrpaz	159	22	these	these	DT
cord-316996-8yimrpaz	159	23	findings	finding	NNS
cord-316996-8yimrpaz	159	24	were	be	VBD
cord-316996-8yimrpaz	159	25	not	not	RB
cord-316996-8yimrpaz	159	26	translated	translate	VBN
cord-316996-8yimrpaz	159	27	into	into	IN
cord-316996-8yimrpaz	159	28	a	a	DT
cord-316996-8yimrpaz	159	29	practical	practical	JJ
cord-316996-8yimrpaz	159	30	approach	approach	NN
cord-316996-8yimrpaz	159	31	until	until	IN
cord-316996-8yimrpaz	159	32	2006	2006	CD
cord-316996-8yimrpaz	159	33	,	,	,
cord-316996-8yimrpaz	159	34	when	when	WRB
cord-316996-8yimrpaz	159	35	there	there	EX
cord-316996-8yimrpaz	159	36	were	be	VBD
cord-316996-8yimrpaz	159	37	two	two	CD
cord-316996-8yimrpaz	159	38	reports	report	NNS
cord-316996-8yimrpaz	159	39	of	of	IN
cord-316996-8yimrpaz	159	40	using	use	VBG
cord-316996-8yimrpaz	159	41	sialidase	sialidase	NN
cord-316996-8yimrpaz	159	42	to	to	TO
cord-316996-8yimrpaz	159	43	successfully	successfully	RB
cord-316996-8yimrpaz	159	44	block	block	VB
cord-316996-8yimrpaz	159	45	respiratory	respiratory	JJ
cord-316996-8yimrpaz	159	46	virus	virus	NN
cord-316996-8yimrpaz	159	47	infection	infection	NN
cord-316996-8yimrpaz	159	48	.	.	.
cord-316996-8yimrpaz	160	1	The	the	DT
cord-316996-8yimrpaz	160	2	first	first	JJ
cord-316996-8yimrpaz	160	3	approach	approach	NN
cord-316996-8yimrpaz	160	4	used	use	VBD
cord-316996-8yimrpaz	160	5	the	the	DT
cord-316996-8yimrpaz	160	6	sialidase	sialidase	NN
cord-316996-8yimrpaz	160	7	from	from	IN
cord-316996-8yimrpaz	160	8	Vibrio	Vibrio	NNP
cord-316996-8yimrpaz	160	9	cholera	cholera	NN
cord-316996-8yimrpaz	160	10	to	to	TO
cord-316996-8yimrpaz	160	11	treat	treat	VB
cord-316996-8yimrpaz	160	12	influenza	influenza	NN
cord-316996-8yimrpaz	160	13	and	and	CC
cord-316996-8yimrpaz	160	14	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	160	15	virus	virus	NNP
cord-316996-8yimrpaz	160	16	three	three	CD
cord-316996-8yimrpaz	160	17	infections	infection	NNS
cord-316996-8yimrpaz	161	1	(	(	-LRB-
cord-316996-8yimrpaz	161	2	Thompson	Thompson	NNP
cord-316996-8yimrpaz	161	3	et	et	NNP
cord-316996-8yimrpaz	161	4	al	al	NNP
cord-316996-8yimrpaz	161	5	.	.	NNP
cord-316996-8yimrpaz	161	6	,	,	,
cord-316996-8yimrpaz	161	7	2006	2006	CD
cord-316996-8yimrpaz	161	8	)	)	-RRB-
cord-316996-8yimrpaz	161	9	,	,	,
cord-316996-8yimrpaz	161	10	while	while	IN
cord-316996-8yimrpaz	161	11	the	the	DT
cord-316996-8yimrpaz	161	12	second	second	NN
cord-316996-8yimrpaz	161	13	used	use	VBD
cord-316996-8yimrpaz	161	14	a	a	DT
cord-316996-8yimrpaz	161	15	bacterial	bacterial	JJ
cord-316996-8yimrpaz	161	16	sialidase	sialidase	NN
cord-316996-8yimrpaz	161	17	that	that	WDT
cord-316996-8yimrpaz	161	18	was	be	VBD
cord-316996-8yimrpaz	161	19	coupled	couple	VBN
cord-316996-8yimrpaz	161	20	to	to	IN
cord-316996-8yimrpaz	161	21	amphiregulin	amphiregulin	NNP
cord-316996-8yimrpaz	161	22	and	and	CC
cord-316996-8yimrpaz	161	23	tested	test	VBN
cord-316996-8yimrpaz	161	24	for	for	IN
cord-316996-8yimrpaz	161	25	anti	anti	JJ
cord-316996-8yimrpaz	161	26	-	-	JJ
cord-316996-8yimrpaz	161	27	influenza	influenza	JJ
cord-316996-8yimrpaz	161	28	activity	activity	NN
cord-316996-8yimrpaz	162	1	(	(	-LRB-
cord-316996-8yimrpaz	162	2	Malakhov	Malakhov	NNP
cord-316996-8yimrpaz	162	3	et	et	NNP
cord-316996-8yimrpaz	162	4	al	al	NNP
cord-316996-8yimrpaz	162	5	.	.	NNP
cord-316996-8yimrpaz	162	6	,	,	,
cord-316996-8yimrpaz	162	7	2006	2006	CD
cord-316996-8yimrpaz	162	8	)	)	-RRB-
cord-316996-8yimrpaz	162	9	.	.	.
cord-316996-8yimrpaz	163	1	This	this	DT
cord-316996-8yimrpaz	163	2	second	second	JJ
cord-316996-8yimrpaz	163	3	compound	compound	NN
cord-316996-8yimrpaz	163	4	,	,	,
cord-316996-8yimrpaz	163	5	called	call	VBN
cord-316996-8yimrpaz	163	6	DAS181	DAS181	NNP
cord-316996-8yimrpaz	163	7	,	,	,
cord-316996-8yimrpaz	163	8	used	use	VBD
cord-316996-8yimrpaz	163	9	the	the	DT
cord-316996-8yimrpaz	163	10	sialidase	sialidase	NN
cord-316996-8yimrpaz	163	11	from	from	IN
cord-316996-8yimrpaz	163	12	A.	A.	NNP
cord-316996-8yimrpaz	163	13	viscosus	viscosus	NN
cord-316996-8yimrpaz	163	14	.	.	.
cord-316996-8yimrpaz	164	1	The	the	DT
cord-316996-8yimrpaz	164	2	coupling	coupling	NN
cord-316996-8yimrpaz	164	3	of	of	IN
cord-316996-8yimrpaz	164	4	sialidase	sialidase	NN
cord-316996-8yimrpaz	164	5	to	to	IN
cord-316996-8yimrpaz	164	6	amphiregulin	amphiregulin	NNP
cord-316996-8yimrpaz	164	7	allowed	allow	VBD
cord-316996-8yimrpaz	164	8	it	-PRON-	PRP
cord-316996-8yimrpaz	164	9	to	to	TO
cord-316996-8yimrpaz	164	10	bind	bind	VB
cord-316996-8yimrpaz	164	11	to	to	IN
cord-316996-8yimrpaz	164	12	the	the	DT
cord-316996-8yimrpaz	164	13	respiratory	respiratory	JJ
cord-316996-8yimrpaz	164	14	epithelium	epithelium	NN
cord-316996-8yimrpaz	164	15	,	,	,
cord-316996-8yimrpaz	164	16	thus	thus	RB
cord-316996-8yimrpaz	164	17	prolonging	prolong	VBG
cord-316996-8yimrpaz	164	18	the	the	DT
cord-316996-8yimrpaz	164	19	duration	duration	NN
cord-316996-8yimrpaz	164	20	of	of	IN
cord-316996-8yimrpaz	164	21	drug	drug	NN
cord-316996-8yimrpaz	164	22	effect	effect	NN
cord-316996-8yimrpaz	164	23	.	.	.
cord-316996-8yimrpaz	165	1	A.	A.	NNP
cord-316996-8yimrpaz	165	2	viscosus	viscosus	NNP
cord-316996-8yimrpaz	165	3	is	be	VBZ
cord-316996-8yimrpaz	165	4	one	one	CD
cord-316996-8yimrpaz	165	5	of	of	IN
cord-316996-8yimrpaz	165	6	the	the	DT
cord-316996-8yimrpaz	165	7	first	first	JJ
cord-316996-8yimrpaz	165	8	bacteria	bacteria	NNS
cord-316996-8yimrpaz	165	9	to	to	TO
cord-316996-8yimrpaz	165	10	colonize	colonize	VB
cord-316996-8yimrpaz	165	11	the	the	DT
cord-316996-8yimrpaz	165	12	surface	surface	NN
cord-316996-8yimrpaz	165	13	of	of	IN
cord-316996-8yimrpaz	165	14	teeth	tooth	NNS
cord-316996-8yimrpaz	165	15	.	.	.
cord-316996-8yimrpaz	166	1	It	-PRON-	PRP
cord-316996-8yimrpaz	166	2	is	be	VBZ
cord-316996-8yimrpaz	166	3	abundantly	abundantly	RB
cord-316996-8yimrpaz	166	4	present	present	JJ
cord-316996-8yimrpaz	166	5	in	in	IN
cord-316996-8yimrpaz	166	6	patients	patient	NNS
cord-316996-8yimrpaz	166	7	with	with	IN
cord-316996-8yimrpaz	166	8	gingivitis	gingivitis	NN
cord-316996-8yimrpaz	167	1	(	(	-LRB-
cord-316996-8yimrpaz	167	2	Haffajee	Haffajee	NNP
cord-316996-8yimrpaz	167	3	et	et	FW
cord-316996-8yimrpaz	167	4	al	al	NNP
cord-316996-8yimrpaz	167	5	.	.	NNP
cord-316996-8yimrpaz	167	6	,	,	,
cord-316996-8yimrpaz	167	7	1997	1997	CD
cord-316996-8yimrpaz	167	8	)	)	-RRB-
cord-316996-8yimrpaz	167	9	,	,	,
cord-316996-8yimrpaz	167	10	and	and	CC
cord-316996-8yimrpaz	167	11	has	have	VBZ
cord-316996-8yimrpaz	167	12	been	be	VBN
cord-316996-8yimrpaz	167	13	implicated	implicate	VBN
cord-316996-8yimrpaz	167	14	in	in	IN
cord-316996-8yimrpaz	167	15	the	the	DT
cord-316996-8yimrpaz	167	16	immunopathogenic	immunopathogenic	JJ
cord-316996-8yimrpaz	167	17	role	role	NN
cord-316996-8yimrpaz	167	18	of	of	IN
cord-316996-8yimrpaz	167	19	periodontal	periodontal	JJ
cord-316996-8yimrpaz	167	20	disease	disease	NN
cord-316996-8yimrpaz	168	1	(	(	-LRB-
cord-316996-8yimrpaz	168	2	Mahanonda	Mahanonda	NNP
cord-316996-8yimrpaz	168	3	et	et	NNP
cord-316996-8yimrpaz	168	4	al	al	NNP
cord-316996-8yimrpaz	168	5	.	.	NNP
cord-316996-8yimrpaz	168	6	,	,	,
cord-316996-8yimrpaz	168	7	1989	1989	CD
cord-316996-8yimrpaz	168	8	)	)	-RRB-
cord-316996-8yimrpaz	168	9	.	.	.
cord-316996-8yimrpaz	169	1	It	-PRON-	PRP
cord-316996-8yimrpaz	169	2	has	have	VBZ
cord-316996-8yimrpaz	169	3	been	be	VBN
cord-316996-8yimrpaz	169	4	proposed	propose	VBN
cord-316996-8yimrpaz	169	5	that	that	IN
cord-316996-8yimrpaz	169	6	continuous	continuous	JJ
cord-316996-8yimrpaz	169	7	swallowing	swallowing	NN
cord-316996-8yimrpaz	169	8	of	of	IN
cord-316996-8yimrpaz	169	9	this	this	DT
cord-316996-8yimrpaz	169	10	bacterium	bacterium	NN
cord-316996-8yimrpaz	169	11	leads	lead	VBZ
cord-316996-8yimrpaz	169	12	to	to	IN
cord-316996-8yimrpaz	169	13	a	a	DT
cord-316996-8yimrpaz	169	14	low	low	JJ
cord-316996-8yimrpaz	169	15	-	-	HYPH
cord-316996-8yimrpaz	169	16	grade	grade	NN
cord-316996-8yimrpaz	169	17	immunological	immunological	JJ
cord-316996-8yimrpaz	169	18	response	response	NN
cord-316996-8yimrpaz	169	19	and	and	CC
cord-316996-8yimrpaz	169	20	the	the	DT
cord-316996-8yimrpaz	169	21	induction	induction	NN
cord-316996-8yimrpaz	169	22	of	of	IN
cord-316996-8yimrpaz	169	23	oral	oral	JJ
cord-316996-8yimrpaz	169	24	bacterial	bacterial	JJ
cord-316996-8yimrpaz	169	25	tolerance	tolerance	NN
cord-316996-8yimrpaz	169	26	(	(	-LRB-
cord-316996-8yimrpaz	169	27	Sosroseno	Sosroseno	NNP
cord-316996-8yimrpaz	169	28	et	et	NNP
cord-316996-8yimrpaz	169	29	al	al	NNP
cord-316996-8yimrpaz	169	30	.	.	NNP
cord-316996-8yimrpaz	169	31	,	,	,
cord-316996-8yimrpaz	169	32	2006	2006	CD
cord-316996-8yimrpaz	169	33	)	)	-RRB-
cord-316996-8yimrpaz	169	34	.	.	.
cord-316996-8yimrpaz	170	1	The	the	DT
cord-316996-8yimrpaz	170	2	sialidase	sialidase	NN
cord-316996-8yimrpaz	170	3	from	from	IN
cord-316996-8yimrpaz	170	4	A.	A.	NNP
cord-316996-8yimrpaz	170	5	viscosus	viscosus	NNP
cord-316996-8yimrpaz	170	6	was	be	VBD
cord-316996-8yimrpaz	170	7	chosen	choose	VBN
cord-316996-8yimrpaz	170	8	for	for	IN
cord-316996-8yimrpaz	170	9	DAS181	DAS181	NNP
cord-316996-8yimrpaz	170	10	three	three	CD
cord-316996-8yimrpaz	170	11	reasons	reason	NNS
cord-316996-8yimrpaz	170	12	.	.	.
cord-316996-8yimrpaz	171	1	Like	like	IN
cord-316996-8yimrpaz	171	2	many	many	JJ
cord-316996-8yimrpaz	171	3	bacterial	bacterial	JJ
cord-316996-8yimrpaz	171	4	sialidases	sialidase	NNS
cord-316996-8yimrpaz	171	5	,	,	,
cord-316996-8yimrpaz	171	6	it	-PRON-	PRP
cord-316996-8yimrpaz	171	7	was	be	VBD
cord-316996-8yimrpaz	171	8	effective	effective	JJ
cord-316996-8yimrpaz	171	9	at	at	IN
cord-316996-8yimrpaz	171	10	cleaving	cleave	VBG
cord-316996-8yimrpaz	171	11	many	many	JJ
cord-316996-8yimrpaz	171	12	types	type	NNS
cord-316996-8yimrpaz	171	13	of	of	IN
cord-316996-8yimrpaz	171	14	Sia	Sia	NNP
cord-316996-8yimrpaz	171	15	;	;	:
cord-316996-8yimrpaz	171	16	it	-PRON-	PRP
cord-316996-8yimrpaz	171	17	had	have	VBD
cord-316996-8yimrpaz	171	18	a	a	DT
cord-316996-8yimrpaz	171	19	high	high	JJ
cord-316996-8yimrpaz	171	20	specific	specific	JJ
cord-316996-8yimrpaz	171	21	activity	activity	NN
cord-316996-8yimrpaz	171	22	;	;	:
cord-316996-8yimrpaz	171	23	and	and	CC
cord-316996-8yimrpaz	171	24	as	as	IN
cord-316996-8yimrpaz	171	25	it	-PRON-	PRP
cord-316996-8yimrpaz	171	26	was	be	VBD
cord-316996-8yimrpaz	171	27	a	a	DT
cord-316996-8yimrpaz	171	28	normal	normal	JJ
cord-316996-8yimrpaz	171	29	commensal	commensal	NN
cord-316996-8yimrpaz	171	30	of	of	IN
cord-316996-8yimrpaz	171	31	the	the	DT
cord-316996-8yimrpaz	171	32	oral	oral	JJ
cord-316996-8yimrpaz	171	33	cavity	cavity	NN
cord-316996-8yimrpaz	171	34	,	,	,
cord-316996-8yimrpaz	171	35	there	there	EX
cord-316996-8yimrpaz	171	36	would	would	MD
cord-316996-8yimrpaz	171	37	not	not	RB
cord-316996-8yimrpaz	171	38	be	be	VB
cord-316996-8yimrpaz	171	39	natural	natural	JJ
cord-316996-8yimrpaz	171	40	antibodies	antibody	NNS
cord-316996-8yimrpaz	171	41	against	against	IN
cord-316996-8yimrpaz	171	42	it	-PRON-	PRP
cord-316996-8yimrpaz	171	43	,	,	,
cord-316996-8yimrpaz	171	44	as	as	IN
cord-316996-8yimrpaz	171	45	a	a	DT
cord-316996-8yimrpaz	171	46	result	result	NN
cord-316996-8yimrpaz	171	47	of	of	IN
cord-316996-8yimrpaz	171	48	oral	oral	JJ
cord-316996-8yimrpaz	171	49	tolerance	tolerance	NN
cord-316996-8yimrpaz	171	50	.	.	.
cord-316996-8yimrpaz	172	1	The	the	DT
cord-316996-8yimrpaz	172	2	sialidase	sialidase	NN
cord-316996-8yimrpaz	172	3	from	from	IN
cord-316996-8yimrpaz	172	4	A.	a.	NN
cord-316996-8yimrpaz	172	5	viscosus	viscosus	NNP
cord-316996-8yimrpaz	172	6	had	have	VBD
cord-316996-8yimrpaz	172	7	been	be	VBN
cord-316996-8yimrpaz	172	8	studied	study	VBN
cord-316996-8yimrpaz	172	9	in	in	IN
cord-316996-8yimrpaz	172	10	1989	1989	CD
cord-316996-8yimrpaz	172	11	by	by	IN
cord-316996-8yimrpaz	172	12	Teufel	Teufel	NNP
cord-316996-8yimrpaz	172	13	and	and	CC
cord-316996-8yimrpaz	172	14	colleagues	colleague	NNS
cord-316996-8yimrpaz	172	15	who	who	WP
cord-316996-8yimrpaz	172	16	found	find	VBD
cord-316996-8yimrpaz	172	17	that	that	IN
cord-316996-8yimrpaz	172	18	it	-PRON-	PRP
cord-316996-8yimrpaz	172	19	was	be	VBD
cord-316996-8yimrpaz	172	20	not	not	RB
cord-316996-8yimrpaz	172	21	primarily	primarily	RB
cord-316996-8yimrpaz	172	22	secreted	secrete	VBN
cord-316996-8yimrpaz	172	23	,	,	,
cord-316996-8yimrpaz	172	24	but	but	CC
cord-316996-8yimrpaz	172	25	cell	cell	NN
cord-316996-8yimrpaz	172	26	-	-	HYPH
cord-316996-8yimrpaz	172	27	bound	bind	VBN
cord-316996-8yimrpaz	172	28	(	(	-LRB-
cord-316996-8yimrpaz	172	29	Teufel	Teufel	NNP
cord-316996-8yimrpaz	172	30	et	et	NNP
cord-316996-8yimrpaz	172	31	al	al	NNP
cord-316996-8yimrpaz	172	32	.	.	NNP
cord-316996-8yimrpaz	172	33	,	,	,
cord-316996-8yimrpaz	172	34	1989	1989	CD
cord-316996-8yimrpaz	172	35	)	)	-RRB-
cord-316996-8yimrpaz	172	36	.	.	.
cord-316996-8yimrpaz	173	1	Though	though	IN
cord-316996-8yimrpaz	173	2	it	-PRON-	PRP
cord-316996-8yimrpaz	173	3	had	have	VBD
cord-316996-8yimrpaz	173	4	a	a	DT
cord-316996-8yimrpaz	173	5	higher	high	JJR
cord-316996-8yimrpaz	173	6	hydrolysis	hydrolysis	NN
cord-316996-8yimrpaz	173	7	rate	rate	NN
cord-316996-8yimrpaz	173	8	against	against	IN
cord-316996-8yimrpaz	173	9	the	the	DT
cord-316996-8yimrpaz	173	10	a2	a2	NNP
cord-316996-8yimrpaz	173	11	-	-	HYPH
cord-316996-8yimrpaz	173	12	6	6	CD
cord-316996-8yimrpaz	173	13	linkage	linkage	NN
cord-316996-8yimrpaz	173	14	,	,	,
cord-316996-8yimrpaz	173	15	it	-PRON-	PRP
cord-316996-8yimrpaz	173	16	was	be	VBD
cord-316996-8yimrpaz	173	17	also	also	RB
cord-316996-8yimrpaz	173	18	effective	effective	JJ
cord-316996-8yimrpaz	173	19	at	at	IN
cord-316996-8yimrpaz	173	20	cleaving	cleave	VBG
cord-316996-8yimrpaz	173	21	a2	a2	NNP
cord-316996-8yimrpaz	173	22	-	-	HYPH
cord-316996-8yimrpaz	173	23	3	3	CD
cord-316996-8yimrpaz	173	24	linkages	linkage	NNS
cord-316996-8yimrpaz	173	25	,	,	,
cord-316996-8yimrpaz	173	26	and	and	CC
cord-316996-8yimrpaz	173	27	was	be	VBD
cord-316996-8yimrpaz	173	28	also	also	RB
cord-316996-8yimrpaz	173	29	able	able	JJ
cord-316996-8yimrpaz	173	30	to	to	TO
cord-316996-8yimrpaz	173	31	cleave	cleave	VB
cord-316996-8yimrpaz	173	32	the	the	DT
cord-316996-8yimrpaz	173	33	ganglioside	ganglioside	NN
cord-316996-8yimrpaz	173	34	GD1a	GD1a	NNP
cord-316996-8yimrpaz	173	35	,	,	,
cord-316996-8yimrpaz	173	36	an	an	DT
cord-316996-8yimrpaz	173	37	uncommon	uncommon	JJ
cord-316996-8yimrpaz	173	38	property	property	NN
cord-316996-8yimrpaz	173	39	among	among	IN
cord-316996-8yimrpaz	173	40	bacterial	bacterial	JJ
cord-316996-8yimrpaz	173	41	sialidases	sialidase	NNS
cord-316996-8yimrpaz	173	42	.	.	.
cord-316996-8yimrpaz	174	1	Acetylation	Acetylation	NNP
cord-316996-8yimrpaz	174	2	at	at	IN
cord-316996-8yimrpaz	174	3	C5,7	C5,7	NNP
cord-316996-8yimrpaz	174	4	and	and	CC
cord-316996-8yimrpaz	174	5	9	9	CD
cord-316996-8yimrpaz	174	6	of	of	IN
cord-316996-8yimrpaz	174	7	Sia	Sia	NNP
cord-316996-8yimrpaz	174	8	still	still	RB
cord-316996-8yimrpaz	174	9	allowed	allow	VBD
cord-316996-8yimrpaz	174	10	cleavage	cleavage	NN
cord-316996-8yimrpaz	174	11	,	,	,
cord-316996-8yimrpaz	174	12	but	but	CC
cord-316996-8yimrpaz	174	13	4-O	4-o	CD
cord-316996-8yimrpaz	174	14	-	-	HYPH
cord-316996-8yimrpaz	174	15	acetylation	acetylation	NN
cord-316996-8yimrpaz	174	16	,	,	,
cord-316996-8yimrpaz	174	17	GM1	GM1	NNP
cord-316996-8yimrpaz	174	18	and	and	CC
cord-316996-8yimrpaz	174	19	Neu5Gc	Neu5Gc	NNP
cord-316996-8yimrpaz	174	20	GM3	GM3	NNS
cord-316996-8yimrpaz	174	21	were	be	VBD
cord-316996-8yimrpaz	174	22	not	not	RB
cord-316996-8yimrpaz	174	23	attacked	attack	VBN
cord-316996-8yimrpaz	174	24	at	at	RB
cord-316996-8yimrpaz	174	25	all	all	RB
cord-316996-8yimrpaz	174	26	.	.	.
cord-316996-8yimrpaz	175	1	Amphiregulin	Amphiregulin	NNP
cord-316996-8yimrpaz	175	2	is	be	VBZ
cord-316996-8yimrpaz	175	3	an	an	DT
cord-316996-8yimrpaz	175	4	84-amino	84-amino	CD
cord-316996-8yimrpaz	175	5	acid	acid	NN
cord-316996-8yimrpaz	175	6	glycoprotein	glycoprotein	NN
cord-316996-8yimrpaz	175	7	that	that	WDT
cord-316996-8yimrpaz	175	8	was	be	VBD
cord-316996-8yimrpaz	175	9	discovered	discover	VBN
cord-316996-8yimrpaz	175	10	in	in	IN
cord-316996-8yimrpaz	175	11	1988	1988	CD
cord-316996-8yimrpaz	175	12	(	(	-LRB-
cord-316996-8yimrpaz	175	13	Shoyab	Shoyab	NNP
cord-316996-8yimrpaz	175	14	et	et	NNP
cord-316996-8yimrpaz	175	15	al	al	NNP
cord-316996-8yimrpaz	175	16	.	.	NNP
cord-316996-8yimrpaz	175	17	,	,	,
cord-316996-8yimrpaz	175	18	1988	1988	CD
cord-316996-8yimrpaz	175	19	)	)	-RRB-
cord-316996-8yimrpaz	175	20	,	,	,
cord-316996-8yimrpaz	175	21	as	as	IN
cord-316996-8yimrpaz	175	22	reviewed	review	VBN
cord-316996-8yimrpaz	175	23	in	in	IN
cord-316996-8yimrpaz	175	24	(	(	-LRB-
cord-316996-8yimrpaz	175	25	Busser	Busser	NNP
cord-316996-8yimrpaz	175	26	et	et	NNP
cord-316996-8yimrpaz	175	27	al	al	NNP
cord-316996-8yimrpaz	175	28	.	.	NNP
cord-316996-8yimrpaz	175	29	,	,	,
cord-316996-8yimrpaz	175	30	2011	2011	CD
cord-316996-8yimrpaz	175	31	)	)	-RRB-
cord-316996-8yimrpaz	175	32	.	.	.
cord-316996-8yimrpaz	176	1	One	one	CD
cord-316996-8yimrpaz	176	2	of	of	IN
cord-316996-8yimrpaz	176	3	its	-PRON-	PRP$
cord-316996-8yimrpaz	176	4	features	feature	NNS
cord-316996-8yimrpaz	176	5	is	be	VBZ
cord-316996-8yimrpaz	176	6	an	an	DT
cord-316996-8yimrpaz	176	7	epidermal	epidermal	JJ
cord-316996-8yimrpaz	176	8	-	-	HYPH
cord-316996-8yimrpaz	176	9	growth	growth	NN
cord-316996-8yimrpaz	176	10	factor	factor	NN
cord-316996-8yimrpaz	176	11	(	(	-LRB-
cord-316996-8yimrpaz	176	12	EGF)-like	egf)-like	NN
cord-316996-8yimrpaz	176	13	domain	domain	NN
cord-316996-8yimrpaz	176	14	,	,	,
cord-316996-8yimrpaz	176	15	which	which	WDT
cord-316996-8yimrpaz	176	16	is	be	VBZ
cord-316996-8yimrpaz	176	17	homologous	homologous	JJ
cord-316996-8yimrpaz	176	18	with	with	IN
cord-316996-8yimrpaz	176	19	other	other	JJ
cord-316996-8yimrpaz	176	20	members	member	NNS
cord-316996-8yimrpaz	176	21	of	of	IN
cord-316996-8yimrpaz	176	22	the	the	DT
cord-316996-8yimrpaz	176	23	EGF	EGF	NNP
cord-316996-8yimrpaz	176	24	-	-	HYPH
cord-316996-8yimrpaz	176	25	like	like	JJ
cord-316996-8yimrpaz	176	26	growth	growth	NN
cord-316996-8yimrpaz	176	27	factor	factor	NN
cord-316996-8yimrpaz	176	28	family	family	NN
cord-316996-8yimrpaz	176	29	,	,	,
cord-316996-8yimrpaz	176	30	meaning	mean	VBG
cord-316996-8yimrpaz	176	31	that	that	IN
cord-316996-8yimrpaz	176	32	it	-PRON-	PRP
cord-316996-8yimrpaz	176	33	can	can	MD
cord-316996-8yimrpaz	176	34	bind	bind	VB
cord-316996-8yimrpaz	176	35	to	to	IN
cord-316996-8yimrpaz	176	36	the	the	DT
cord-316996-8yimrpaz	176	37	EGF	EGF	NNP
cord-316996-8yimrpaz	176	38	receptor	receptor	NN
cord-316996-8yimrpaz	176	39	present	present	NN
cord-316996-8yimrpaz	176	40	on	on	IN
cord-316996-8yimrpaz	176	41	epithelial	epithelial	JJ
cord-316996-8yimrpaz	176	42	cells	cell	NNS
cord-316996-8yimrpaz	176	43	.	.	.
cord-316996-8yimrpaz	177	1	Unlike	unlike	IN
cord-316996-8yimrpaz	177	2	many	many	JJ
cord-316996-8yimrpaz	177	3	other	other	JJ
cord-316996-8yimrpaz	177	4	members	member	NNS
cord-316996-8yimrpaz	177	5	of	of	IN
cord-316996-8yimrpaz	177	6	the	the	DT
cord-316996-8yimrpaz	177	7	EGF	EGF	NNP
cord-316996-8yimrpaz	177	8	family	family	NN
cord-316996-8yimrpaz	177	9	,	,	,
cord-316996-8yimrpaz	177	10	amphiregulin	amphiregulin	NNP
cord-316996-8yimrpaz	177	11	binding	binding	NN
cord-316996-8yimrpaz	177	12	does	do	VBZ
cord-316996-8yimrpaz	177	13	not	not	RB
cord-316996-8yimrpaz	177	14	lead	lead	VB
cord-316996-8yimrpaz	177	15	to	to	IN
cord-316996-8yimrpaz	177	16	EGFR	EGFR	NNP
cord-316996-8yimrpaz	177	17	degradation	degradation	NN
cord-316996-8yimrpaz	177	18	,	,	,
cord-316996-8yimrpaz	177	19	but	but	CC
cord-316996-8yimrpaz	177	20	to	to	IN
cord-316996-8yimrpaz	177	21	recycling	recycling	NN
cord-316996-8yimrpaz	177	22	of	of	IN
cord-316996-8yimrpaz	177	23	the	the	DT
cord-316996-8yimrpaz	177	24	receptor	receptor	NN
cord-316996-8yimrpaz	177	25	and	and	CC
cord-316996-8yimrpaz	177	26	continued	continue	VBN
cord-316996-8yimrpaz	177	27	accumulation	accumulation	NN
cord-316996-8yimrpaz	177	28	at	at	IN
cord-316996-8yimrpaz	177	29	the	the	DT
cord-316996-8yimrpaz	177	30	surface	surface	NN
cord-316996-8yimrpaz	178	1	(	(	-LRB-
cord-316996-8yimrpaz	178	2	Willmarth	Willmarth	NNP
cord-316996-8yimrpaz	178	3	et	et	NNP
cord-316996-8yimrpaz	178	4	al	al	NNP
cord-316996-8yimrpaz	178	5	.	.	NNP
cord-316996-8yimrpaz	178	6	,	,	,
cord-316996-8yimrpaz	178	7	2009	2009	CD
cord-316996-8yimrpaz	178	8	)	)	-RRB-
cord-316996-8yimrpaz	178	9	.	.	.
cord-316996-8yimrpaz	179	1	At	at	IN
cord-316996-8yimrpaz	179	2	the	the	DT
cord-316996-8yimrpaz	179	3	other	other	JJ
cord-316996-8yimrpaz	179	4	end	end	NN
cord-316996-8yimrpaz	179	5	of	of	IN
cord-316996-8yimrpaz	179	6	the	the	DT
cord-316996-8yimrpaz	179	7	protein	protein	NN
cord-316996-8yimrpaz	179	8	is	be	VBZ
cord-316996-8yimrpaz	179	9	a	a	DT
cord-316996-8yimrpaz	179	10	heparin	heparin	NN
cord-316996-8yimrpaz	179	11	-	-	:
cord-316996-8yimrpaz	179	12	and	and	CC
cord-316996-8yimrpaz	179	13	glycosaminoglycan	glycosaminoglycan	NN
cord-316996-8yimrpaz	179	14	-	-	HYPH
cord-316996-8yimrpaz	179	15	binding	bind	VBG
cord-316996-8yimrpaz	179	16	domain	domain	NN
cord-316996-8yimrpaz	179	17	,	,	,
cord-316996-8yimrpaz	179	18	which	which	WDT
cord-316996-8yimrpaz	179	19	is	be	VBZ
cord-316996-8yimrpaz	179	20	involved	involve	VBN
cord-316996-8yimrpaz	179	21	in	in	IN
cord-316996-8yimrpaz	179	22	the	the	DT
cord-316996-8yimrpaz	179	23	inhibition	inhibition	NN
cord-316996-8yimrpaz	179	24	or	or	CC
cord-316996-8yimrpaz	179	25	transformation	transformation	NN
cord-316996-8yimrpaz	179	26	of	of	IN
cord-316996-8yimrpaz	179	27	this	this	DT
cord-316996-8yimrpaz	179	28	glycoprotein	glycoprotein	NN
cord-316996-8yimrpaz	179	29	(	(	-LRB-
cord-316996-8yimrpaz	179	30	hence	hence	RB
cord-316996-8yimrpaz	179	31	the	the	DT
cord-316996-8yimrpaz	179	32	name	name	NN
cord-316996-8yimrpaz	179	33	amphi	amphi	NNP
cord-316996-8yimrpaz	179	34	-	-	:
cord-316996-8yimrpaz	179	35	regulin	regulin	NNP
cord-316996-8yimrpaz	179	36	)	)	-RRB-
cord-316996-8yimrpaz	179	37	.	.	.
cord-316996-8yimrpaz	180	1	In	in	IN
cord-316996-8yimrpaz	180	2	the	the	DT
cord-316996-8yimrpaz	180	3	case	case	NN
cord-316996-8yimrpaz	180	4	of	of	IN
cord-316996-8yimrpaz	180	5	DAS181	DAS181	NNP
cord-316996-8yimrpaz	180	6	,	,	,
cord-316996-8yimrpaz	180	7	the	the	DT
cord-316996-8yimrpaz	180	8	sialidase	sialidase	NN
cord-316996-8yimrpaz	180	9	was	be	VBD
cord-316996-8yimrpaz	180	10	combined	combine	VBN
cord-316996-8yimrpaz	180	11	with	with	IN
cord-316996-8yimrpaz	180	12	the	the	DT
cord-316996-8yimrpaz	180	13	GAG	gag	NN
cord-316996-8yimrpaz	180	14	-	-	HYPH
cord-316996-8yimrpaz	180	15	binding	bind	VBG
cord-316996-8yimrpaz	180	16	portion	portion	NN
cord-316996-8yimrpaz	180	17	of	of	IN
cord-316996-8yimrpaz	180	18	human	human	JJ
cord-316996-8yimrpaz	180	19	AR	AR	NNP
cord-316996-8yimrpaz	180	20	.	.	.
cord-316996-8yimrpaz	181	1	By	by	IN
cord-316996-8yimrpaz	181	2	binding	bind	VBG
cord-316996-8yimrpaz	181	3	to	to	IN
cord-316996-8yimrpaz	181	4	the	the	DT
cord-316996-8yimrpaz	181	5	negatively	negatively	RB
cord-316996-8yimrpaz	181	6	-	-	HYPH
cord-316996-8yimrpaz	181	7	charged	charge	VBN
cord-316996-8yimrpaz	181	8	glycosaminoglycans	glycosaminoglycan	NNS
cord-316996-8yimrpaz	181	9	on	on	IN
cord-316996-8yimrpaz	181	10	the	the	DT
cord-316996-8yimrpaz	181	11	surface	surface	NN
cord-316996-8yimrpaz	181	12	of	of	IN
cord-316996-8yimrpaz	181	13	airway	airway	NN
cord-316996-8yimrpaz	181	14	epithelial	epithelial	JJ
cord-316996-8yimrpaz	181	15	cells	cell	NNS
cord-316996-8yimrpaz	181	16	,	,	,
cord-316996-8yimrpaz	181	17	the	the	DT
cord-316996-8yimrpaz	181	18	cationic	cationic	JJ
cord-316996-8yimrpaz	181	19	C	C	NNP
cord-316996-8yimrpaz	181	20	-	-	HYPH
cord-316996-8yimrpaz	181	21	terminal	terminal	NN
cord-316996-8yimrpaz	181	22	amphiregulin	amphiregulin	NNP
cord-316996-8yimrpaz	181	23	tag	tag	NN
cord-316996-8yimrpaz	181	24	anchors	anchor	NNS
cord-316996-8yimrpaz	181	25	DAS181	DAS181	NNP
cord-316996-8yimrpaz	181	26	on	on	IN
cord-316996-8yimrpaz	181	27	the	the	DT
cord-316996-8yimrpaz	181	28	respiratory	respiratory	JJ
cord-316996-8yimrpaz	181	29	epithelium	epithelium	NN
cord-316996-8yimrpaz	181	30	,	,	,
cord-316996-8yimrpaz	181	31	improving	improve	VBG
cord-316996-8yimrpaz	181	32	its	-PRON-	PRP$
cord-316996-8yimrpaz	181	33	potency	potency	NN
cord-316996-8yimrpaz	181	34	.	.	.
cord-316996-8yimrpaz	182	1	This	this	DT
cord-316996-8yimrpaz	182	2	net	net	JJ
cord-316996-8yimrpaz	182	3	effect	effect	NN
cord-316996-8yimrpaz	182	4	of	of	IN
cord-316996-8yimrpaz	182	5	combining	combine	VBG
cord-316996-8yimrpaz	182	6	the	the	DT
cord-316996-8yimrpaz	182	7	sialidase	sialidase	NN
cord-316996-8yimrpaz	182	8	with	with	IN
cord-316996-8yimrpaz	182	9	amphiregulin	amphiregulin	NNP
cord-316996-8yimrpaz	182	10	means	mean	VBZ
cord-316996-8yimrpaz	182	11	that	that	IN
cord-316996-8yimrpaz	182	12	the	the	DT
cord-316996-8yimrpaz	182	13	sialidase	sialidase	NN
cord-316996-8yimrpaz	182	14	will	will	MD
cord-316996-8yimrpaz	182	15	be	be	VB
cord-316996-8yimrpaz	182	16	targeted	target	VBN
cord-316996-8yimrpaz	182	17	to	to	IN
cord-316996-8yimrpaz	182	18	epithelial	epithelial	JJ
cord-316996-8yimrpaz	182	19	cells	cell	NNS
cord-316996-8yimrpaz	182	20	lining	line	VBG
cord-316996-8yimrpaz	182	21	the	the	DT
cord-316996-8yimrpaz	182	22	respiratory	respiratory	JJ
cord-316996-8yimrpaz	182	23	tract	tract	NN
cord-316996-8yimrpaz	182	24	,	,	,
cord-316996-8yimrpaz	182	25	but	but	CC
cord-316996-8yimrpaz	182	26	without	without	IN
cord-316996-8yimrpaz	182	27	activating	activate	VBG
cord-316996-8yimrpaz	182	28	the	the	DT
cord-316996-8yimrpaz	182	29	EGFR	EGFR	NNP
cord-316996-8yimrpaz	182	30	pathway	pathway	NN
cord-316996-8yimrpaz	182	31	.	.	.
cord-316996-8yimrpaz	183	1	DAS181	DAS181	NNP
cord-316996-8yimrpaz	183	2	was	be	VBD
cord-316996-8yimrpaz	183	3	tested	test	VBN
cord-316996-8yimrpaz	183	4	in	in	IN
cord-316996-8yimrpaz	183	5	ferret	ferret	JJ
cord-316996-8yimrpaz	183	6	and	and	CC
cord-316996-8yimrpaz	183	7	human	human	JJ
cord-316996-8yimrpaz	183	8	airway	airway	NN
cord-316996-8yimrpaz	183	9	epithelium	epithelium	NN
cord-316996-8yimrpaz	183	10	models	model	NNS
cord-316996-8yimrpaz	183	11	and	and	CC
cord-316996-8yimrpaz	183	12	was	be	VBD
cord-316996-8yimrpaz	183	13	shown	show	VBN
cord-316996-8yimrpaz	183	14	to	to	TO
cord-316996-8yimrpaz	183	15	have	have	VB
cord-316996-8yimrpaz	183	16	activity	activity	NN
cord-316996-8yimrpaz	183	17	against	against	IN
cord-316996-8yimrpaz	183	18	a	a	DT
cord-316996-8yimrpaz	183	19	wide	wide	JJ
cord-316996-8yimrpaz	183	20	range	range	NN
cord-316996-8yimrpaz	183	21	of	of	IN
cord-316996-8yimrpaz	183	22	influenza	influenza	NN
cord-316996-8yimrpaz	183	23	A	a	NN
cord-316996-8yimrpaz	183	24	and	and	CC
cord-316996-8yimrpaz	183	25	B	b	NN
cord-316996-8yimrpaz	183	26	viruses	virus	NNS
cord-316996-8yimrpaz	184	1	(	(	-LRB-
cord-316996-8yimrpaz	184	2	Malakhov	Malakhov	NNP
cord-316996-8yimrpaz	184	3	et	et	NNP
cord-316996-8yimrpaz	184	4	al	al	NNP
cord-316996-8yimrpaz	184	5	.	.	NNP
cord-316996-8yimrpaz	184	6	,	,	,
cord-316996-8yimrpaz	184	7	2006	2006	CD
cord-316996-8yimrpaz	184	8	)	)	-RRB-
cord-316996-8yimrpaz	184	9	.	.	.
cord-316996-8yimrpaz	185	1	Compared	compare	VBN
cord-316996-8yimrpaz	185	2	to	to	IN
cord-316996-8yimrpaz	185	3	other	other	JJ
cord-316996-8yimrpaz	185	4	sialidases	sialidase	NNS
cord-316996-8yimrpaz	185	5	,	,	,
cord-316996-8yimrpaz	185	6	DAS181	DAS181	NNP
cord-316996-8yimrpaz	185	7	had	have	VBD
cord-316996-8yimrpaz	185	8	higher	high	JJR
cord-316996-8yimrpaz	185	9	activity	activity	NN
cord-316996-8yimrpaz	185	10	and	and	CC
cord-316996-8yimrpaz	185	11	was	be	VBD
cord-316996-8yimrpaz	185	12	stable	stable	JJ
cord-316996-8yimrpaz	185	13	over	over	IN
cord-316996-8yimrpaz	185	14	a	a	DT
cord-316996-8yimrpaz	185	15	wide	wide	JJ
cord-316996-8yimrpaz	185	16	range	range	NN
cord-316996-8yimrpaz	185	17	of	of	IN
cord-316996-8yimrpaz	185	18	pH	ph	NN
cord-316996-8yimrpaz	185	19	values	value	NNS
cord-316996-8yimrpaz	185	20	that	that	WDT
cord-316996-8yimrpaz	185	21	would	would	MD
cord-316996-8yimrpaz	185	22	be	be	VB
cord-316996-8yimrpaz	185	23	present	present	JJ
cord-316996-8yimrpaz	185	24	in	in	IN
cord-316996-8yimrpaz	185	25	the	the	DT
cord-316996-8yimrpaz	185	26	respiratory	respiratory	JJ
cord-316996-8yimrpaz	185	27	tract	tract	NN
cord-316996-8yimrpaz	185	28	.	.	.
cord-316996-8yimrpaz	186	1	After	after	IN
cord-316996-8yimrpaz	186	2	a	a	DT
cord-316996-8yimrpaz	186	3	single	single	JJ
cord-316996-8yimrpaz	186	4	treatment	treatment	NN
cord-316996-8yimrpaz	186	5	,	,	,
cord-316996-8yimrpaz	186	6	there	there	EX
cord-316996-8yimrpaz	186	7	was	be	VBD
cord-316996-8yimrpaz	186	8	effective	effective	JJ
cord-316996-8yimrpaz	186	9	desialylation	desialylation	NN
cord-316996-8yimrpaz	186	10	of	of	IN
cord-316996-8yimrpaz	186	11	MDCK	MDCK	NNP
cord-316996-8yimrpaz	186	12	cells	cell	NNS
cord-316996-8yimrpaz	186	13	for	for	IN
cord-316996-8yimrpaz	186	14	2	2	CD
cord-316996-8yimrpaz	186	15	days	day	NNS
cord-316996-8yimrpaz	186	16	and	and	CC
cord-316996-8yimrpaz	186	17	recovery	recovery	NN
cord-316996-8yimrpaz	186	18	to	to	IN
cord-316996-8yimrpaz	186	19	80	80	CD
cord-316996-8yimrpaz	186	20	%	%	NN
cord-316996-8yimrpaz	186	21	after	after	IN
cord-316996-8yimrpaz	186	22	4	4	CD
cord-316996-8yimrpaz	186	23	days	day	NNS
cord-316996-8yimrpaz	186	24	;	;	:
cord-316996-8yimrpaz	186	25	however	however	RB
cord-316996-8yimrpaz	186	26	,	,	,
cord-316996-8yimrpaz	186	27	later	later	JJ
cord-316996-8yimrpaz	186	28	treatment	treatment	NN
cord-316996-8yimrpaz	186	29	regimens	regimen	NNS
cord-316996-8yimrpaz	186	30	adopted	adopt	VBD
cord-316996-8yimrpaz	186	31	a	a	DT
cord-316996-8yimrpaz	186	32	daily	daily	JJ
cord-316996-8yimrpaz	186	33	dosing	dosing	NN
cord-316996-8yimrpaz	186	34	schedule	schedule	NN
cord-316996-8yimrpaz	186	35	.	.	.
cord-316996-8yimrpaz	187	1	The	the	DT
cord-316996-8yimrpaz	187	2	amphiregulin	amphiregulin	NN
cord-316996-8yimrpaz	187	3	attachment	attachment	NN
cord-316996-8yimrpaz	187	4	increased	increase	VBD
cord-316996-8yimrpaz	187	5	the	the	DT
cord-316996-8yimrpaz	187	6	potency	potency	NN
cord-316996-8yimrpaz	187	7	5	5	CD
cord-316996-8yimrpaz	187	8	-	-	HYPH
cord-316996-8yimrpaz	187	9	30-fold	30-fold	CD
cord-316996-8yimrpaz	188	1	(	(	-LRB-
cord-316996-8yimrpaz	188	2	Malakhov	Malakhov	NNP
cord-316996-8yimrpaz	188	3	et	et	NNP
cord-316996-8yimrpaz	188	4	al	al	NNP
cord-316996-8yimrpaz	188	5	.	.	NNP
cord-316996-8yimrpaz	188	6	,	,	,
cord-316996-8yimrpaz	188	7	2006	2006	CD
cord-316996-8yimrpaz	188	8	)	)	-RRB-
cord-316996-8yimrpaz	188	9	.	.	.
cord-316996-8yimrpaz	189	1	There	there	EX
cord-316996-8yimrpaz	189	2	was	be	VBD
cord-316996-8yimrpaz	189	3	no	no	DT
cord-316996-8yimrpaz	189	4	appreciable	appreciable	JJ
cord-316996-8yimrpaz	189	5	cell	cell	NN
cord-316996-8yimrpaz	189	6	toxicity	toxicity	NN
cord-316996-8yimrpaz	189	7	in	in	IN
cord-316996-8yimrpaz	189	8	a	a	DT
cord-316996-8yimrpaz	189	9	number	number	NN
cord-316996-8yimrpaz	189	10	of	of	IN
cord-316996-8yimrpaz	189	11	established	establish	VBN
cord-316996-8yimrpaz	189	12	cell	cell	NN
cord-316996-8yimrpaz	189	13	lines	line	NNS
cord-316996-8yimrpaz	189	14	,	,	,
cord-316996-8yimrpaz	189	15	and	and	CC
cord-316996-8yimrpaz	189	16	no	no	DT
cord-316996-8yimrpaz	189	17	endogenous	endogenous	JJ
cord-316996-8yimrpaz	189	18	production	production	NN
cord-316996-8yimrpaz	189	19	of	of	IN
cord-316996-8yimrpaz	189	20	interferon	interferon	NN
cord-316996-8yimrpaz	189	21	or	or	CC
cord-316996-8yimrpaz	189	22	TNFa	TNFa	NNP
cord-316996-8yimrpaz	189	23	was	be	VBD
cord-316996-8yimrpaz	189	24	seen	see	VBN
cord-316996-8yimrpaz	189	25	,	,	,
cord-316996-8yimrpaz	189	26	indicating	indicate	VBG
cord-316996-8yimrpaz	189	27	that	that	IN
cord-316996-8yimrpaz	189	28	the	the	DT
cord-316996-8yimrpaz	189	29	amphiregulin	amphiregulin	NNP
cord-316996-8yimrpaz	189	30	tag	tag	NNP
cord-316996-8yimrpaz	189	31	was	be	VBD
cord-316996-8yimrpaz	189	32	not	not	RB
cord-316996-8yimrpaz	189	33	detrimental	detrimental	JJ
cord-316996-8yimrpaz	189	34	to	to	IN
cord-316996-8yimrpaz	189	35	the	the	DT
cord-316996-8yimrpaz	189	36	host	host	NN
cord-316996-8yimrpaz	189	37	cells	cell	NNS
cord-316996-8yimrpaz	189	38	.	.	.
cord-316996-8yimrpaz	190	1	Inhalation	inhalation	NN
cord-316996-8yimrpaz	190	2	toxicity	toxicity	NN
cord-316996-8yimrpaz	190	3	was	be	VBD
cord-316996-8yimrpaz	190	4	evaluated	evaluate	VBN
cord-316996-8yimrpaz	190	5	in	in	IN
cord-316996-8yimrpaz	190	6	Sprague	Sprague	NNP
cord-316996-8yimrpaz	190	7	-	-	HYPH
cord-316996-8yimrpaz	190	8	Dawley	Dawley	NNP
cord-316996-8yimrpaz	190	9	rats	rat	NNS
cord-316996-8yimrpaz	190	10	.	.	.
cord-316996-8yimrpaz	191	1	Repeated	repeat	VBN
cord-316996-8yimrpaz	191	2	daily	daily	JJ
cord-316996-8yimrpaz	191	3	exposures	exposure	NNS
cord-316996-8yimrpaz	191	4	of	of	IN
cord-316996-8yimrpaz	191	5	inhaled	inhale	VBN
cord-316996-8yimrpaz	191	6	DAS181	DAS181	NNP
cord-316996-8yimrpaz	191	7	for	for	IN
cord-316996-8yimrpaz	191	8	28	28	CD
cord-316996-8yimrpaz	191	9	days	day	NNS
cord-316996-8yimrpaz	191	10	at	at	IN
cord-316996-8yimrpaz	191	11	achieved	achieve	VBN
cord-316996-8yimrpaz	191	12	doses	dose	NNS
cord-316996-8yimrpaz	191	13	of	of	IN
cord-316996-8yimrpaz	191	14	up	up	IN
cord-316996-8yimrpaz	191	15	to	to	TO
cord-316996-8yimrpaz	191	16	3.00	3.00	CD
cord-316996-8yimrpaz	191	17	mg	mg	NNP
cord-316996-8yimrpaz	191	18	/	/	SYM
cord-316996-8yimrpaz	191	19	kg	kg	NNP
cord-316996-8yimrpaz	191	20	/	/	SYM
cord-316996-8yimrpaz	191	21	day	day	NN
cord-316996-8yimrpaz	191	22	were	be	VBD
cord-316996-8yimrpaz	191	23	well	well	RB
cord-316996-8yimrpaz	191	24	tolerated	tolerate	VBN
cord-316996-8yimrpaz	191	25	,	,	,
cord-316996-8yimrpaz	191	26	and	and	CC
cord-316996-8yimrpaz	191	27	clinical	clinical	JJ
cord-316996-8yimrpaz	191	28	signs	sign	NNS
cord-316996-8yimrpaz	191	29	were	be	VBD
cord-316996-8yimrpaz	191	30	not	not	RB
cord-316996-8yimrpaz	191	31	affected	affect	VBN
cord-316996-8yimrpaz	191	32	by	by	IN
cord-316996-8yimrpaz	191	33	treatment	treatment	NN
cord-316996-8yimrpaz	191	34	with	with	IN
cord-316996-8yimrpaz	191	35	DAS181	DAS181	NNP
cord-316996-8yimrpaz	191	36	.	.	.
cord-316996-8yimrpaz	192	1	Minimal	minimal	JJ
cord-316996-8yimrpaz	192	2	but	but	CC
cord-316996-8yimrpaz	192	3	significant	significant	JJ
cord-316996-8yimrpaz	192	4	decreases	decrease	NNS
cord-316996-8yimrpaz	192	5	in	in	IN
cord-316996-8yimrpaz	192	6	red	red	JJ
cord-316996-8yimrpaz	192	7	blood	blood	NN
cord-316996-8yimrpaz	192	8	cells	cell	NNS
cord-316996-8yimrpaz	192	9	,	,	,
cord-316996-8yimrpaz	192	10	haematocrit	haematocrit	NN
cord-316996-8yimrpaz	192	11	and	and	CC
cord-316996-8yimrpaz	192	12	hemoglobin	hemoglobin	NN
cord-316996-8yimrpaz	192	13	were	be	VBD
cord-316996-8yimrpaz	192	14	identified	identify	VBN
cord-316996-8yimrpaz	192	15	,	,	,
cord-316996-8yimrpaz	192	16	together	together	RB
cord-316996-8yimrpaz	192	17	with	with	IN
cord-316996-8yimrpaz	192	18	an	an	DT
cord-316996-8yimrpaz	192	19	increased	increase	VBN
cord-316996-8yimrpaz	192	20	reticulocyte	reticulocyte	NN
cord-316996-8yimrpaz	192	21	count	count	NN
cord-316996-8yimrpaz	192	22	,	,	,
cord-316996-8yimrpaz	192	23	in	in	IN
cord-316996-8yimrpaz	192	24	keeping	keep	VBG
cord-316996-8yimrpaz	192	25	with	with	IN
cord-316996-8yimrpaz	192	26	a	a	DT
cord-316996-8yimrpaz	192	27	mild	mild	JJ
cord-316996-8yimrpaz	192	28	anemia	anemia	NN
cord-316996-8yimrpaz	192	29	;	;	:
cord-316996-8yimrpaz	192	30	systemic	systemic	JJ
cord-316996-8yimrpaz	192	31	absorption	absorption	NN
cord-316996-8yimrpaz	192	32	from	from	IN
cord-316996-8yimrpaz	192	33	the	the	DT
cord-316996-8yimrpaz	192	34	respiratory	respiratory	JJ
cord-316996-8yimrpaz	192	35	tract	tract	NN
cord-316996-8yimrpaz	192	36	was	be	VBD
cord-316996-8yimrpaz	192	37	estimated	estimate	VBN
cord-316996-8yimrpaz	192	38	at	at	IN
cord-316996-8yimrpaz	192	39	2	2	CD
cord-316996-8yimrpaz	192	40	%	%	NN
cord-316996-8yimrpaz	193	1	(	(	-LRB-
cord-316996-8yimrpaz	193	2	Larson	Larson	NNP
cord-316996-8yimrpaz	193	3	et	et	NNP
cord-316996-8yimrpaz	193	4	al	al	NNP
cord-316996-8yimrpaz	193	5	.	.	NNP
cord-316996-8yimrpaz	193	6	,	,	,
cord-316996-8yimrpaz	193	7	2011	2011	CD
cord-316996-8yimrpaz	193	8	)	)	-RRB-
cord-316996-8yimrpaz	193	9	.	.	.
cord-316996-8yimrpaz	194	1	In	in	IN
cord-316996-8yimrpaz	194	2	this	this	DT
cord-316996-8yimrpaz	194	3	study	study	NN
cord-316996-8yimrpaz	194	4	there	there	EX
cord-316996-8yimrpaz	194	5	was	be	VBD
cord-316996-8yimrpaz	194	6	also	also	RB
cord-316996-8yimrpaz	194	7	a	a	DT
cord-316996-8yimrpaz	194	8	3-fold	3-fold	CD
cord-316996-8yimrpaz	194	9	increase	increase	NN
cord-316996-8yimrpaz	194	10	in	in	IN
cord-316996-8yimrpaz	194	11	alkaline	alkaline	JJ
cord-316996-8yimrpaz	194	12	phosphatase	phosphatase	NN
cord-316996-8yimrpaz	194	13	(	(	-LRB-
cord-316996-8yimrpaz	194	14	ALP	ALP	NNP
cord-316996-8yimrpaz	194	15	)	)	-RRB-
cord-316996-8yimrpaz	194	16	from	from	IN
cord-316996-8yimrpaz	194	17	the	the	DT
cord-316996-8yimrpaz	194	18	liver	liver	NN
cord-316996-8yimrpaz	194	19	,	,	,
cord-316996-8yimrpaz	194	20	which	which	WDT
cord-316996-8yimrpaz	194	21	was	be	VBD
cord-316996-8yimrpaz	194	22	attributed	attribute	VBN
cord-316996-8yimrpaz	194	23	to	to	IN
cord-316996-8yimrpaz	194	24	diminished	diminished	JJ
cord-316996-8yimrpaz	194	25	clearance	clearance	NN
cord-316996-8yimrpaz	194	26	,	,	,
cord-316996-8yimrpaz	194	27	owing	owe	VBG
cord-316996-8yimrpaz	194	28	to	to	IN
cord-316996-8yimrpaz	194	29	competition	competition	NN
cord-316996-8yimrpaz	194	30	for	for	IN
cord-316996-8yimrpaz	194	31	the	the	DT
cord-316996-8yimrpaz	194	32	asialoglycoprotein	asialoglycoprotein	NNP
cord-316996-8yimrpaz	194	33	receptor	receptor	NN
cord-316996-8yimrpaz	194	34	.	.	.
cord-316996-8yimrpaz	195	1	The	the	DT
cord-316996-8yimrpaz	195	2	rise	rise	NN
cord-316996-8yimrpaz	195	3	in	in	IN
cord-316996-8yimrpaz	195	4	ALP	ALP	NNP
cord-316996-8yimrpaz	195	5	was	be	VBD
cord-316996-8yimrpaz	195	6	not	not	RB
cord-316996-8yimrpaz	195	7	associated	associate	VBN
cord-316996-8yimrpaz	195	8	with	with	IN
cord-316996-8yimrpaz	195	9	any	any	DT
cord-316996-8yimrpaz	195	10	evidence	evidence	NN
cord-316996-8yimrpaz	195	11	of	of	IN
cord-316996-8yimrpaz	195	12	hepatotoxicity	hepatotoxicity	NN
cord-316996-8yimrpaz	195	13	.	.	.
cord-316996-8yimrpaz	196	1	It	-PRON-	PRP
cord-316996-8yimrpaz	196	2	is	be	VBZ
cord-316996-8yimrpaz	196	3	thought	think	VBN
cord-316996-8yimrpaz	196	4	that	that	IN
cord-316996-8yimrpaz	196	5	desialylation	desialylation	NN
cord-316996-8yimrpaz	196	6	of	of	IN
cord-316996-8yimrpaz	196	7	the	the	DT
cord-316996-8yimrpaz	196	8	serum	serum	NN
cord-316996-8yimrpaz	196	9	proteins	protein	NNS
cord-316996-8yimrpaz	196	10	may	may	MD
cord-316996-8yimrpaz	196	11	lead	lead	VB
cord-316996-8yimrpaz	196	12	to	to	IN
cord-316996-8yimrpaz	196	13	saturation	saturation	NN
cord-316996-8yimrpaz	196	14	of	of	IN
cord-316996-8yimrpaz	196	15	the	the	DT
cord-316996-8yimrpaz	196	16	asialoglycoprotein	asialoglycoprotein	NNP
cord-316996-8yimrpaz	196	17	receptors	receptor	NNS
cord-316996-8yimrpaz	196	18	(	(	-LRB-
cord-316996-8yimrpaz	196	19	ASGR	ASGR	NNP
cord-316996-8yimrpaz	196	20	)	)	-RRB-
cord-316996-8yimrpaz	196	21	in	in	IN
cord-316996-8yimrpaz	196	22	the	the	DT
cord-316996-8yimrpaz	196	23	liver	liver	NN
cord-316996-8yimrpaz	196	24	and	and	CC
cord-316996-8yimrpaz	196	25	spleen	spleen	NNS
cord-316996-8yimrpaz	196	26	,	,	,
cord-316996-8yimrpaz	196	27	and	and	CC
cord-316996-8yimrpaz	196	28	reduced	reduced	JJ
cord-316996-8yimrpaz	196	29	clearance	clearance	NN
cord-316996-8yimrpaz	196	30	of	of	IN
cord-316996-8yimrpaz	196	31	certain	certain	JJ
cord-316996-8yimrpaz	196	32	glycoproteins	glycoprotein	NNS
cord-316996-8yimrpaz	196	33	,	,	,
cord-316996-8yimrpaz	196	34	including	include	VBG
cord-316996-8yimrpaz	196	35	ALP	ALP	NNP
cord-316996-8yimrpaz	196	36	.	.	.
cord-316996-8yimrpaz	197	1	Further	further	JJ
cord-316996-8yimrpaz	197	2	studies	study	NNS
cord-316996-8yimrpaz	197	3	were	be	VBD
cord-316996-8yimrpaz	197	4	done	do	VBN
cord-316996-8yimrpaz	197	5	on	on	IN
cord-316996-8yimrpaz	197	6	human	human	JJ
cord-316996-8yimrpaz	197	7	airway	airway	NN
cord-316996-8yimrpaz	197	8	epithelial	epithelial	JJ
cord-316996-8yimrpaz	197	9	cells	cell	NNS
cord-316996-8yimrpaz	197	10	.	.	.
cord-316996-8yimrpaz	198	1	In	in	IN
cord-316996-8yimrpaz	198	2	this	this	DT
cord-316996-8yimrpaz	198	3	study	study	NN
cord-316996-8yimrpaz	198	4	,	,	,
cord-316996-8yimrpaz	198	5	a	a	DT
cord-316996-8yimrpaz	198	6	90	90	CD
cord-316996-8yimrpaz	198	7	%	%	NN
cord-316996-8yimrpaz	198	8	desialylation	desialylation	NN
cord-316996-8yimrpaz	198	9	effect	effect	NN
cord-316996-8yimrpaz	198	10	was	be	VBD
cord-316996-8yimrpaz	198	11	seen	see	VBN
cord-316996-8yimrpaz	198	12	after	after	IN
cord-316996-8yimrpaz	198	13	15	15	CD
cord-316996-8yimrpaz	198	14	min	min	NN
cord-316996-8yimrpaz	198	15	,	,	,
cord-316996-8yimrpaz	198	16	and	and	CC
cord-316996-8yimrpaz	198	17	the	the	DT
cord-316996-8yimrpaz	198	18	presence	presence	NN
cord-316996-8yimrpaz	198	19	of	of	IN
cord-316996-8yimrpaz	198	20	mucus	mucus	NN
cord-316996-8yimrpaz	198	21	did	do	VBD
cord-316996-8yimrpaz	198	22	not	not	RB
cord-316996-8yimrpaz	198	23	interfere	interfere	VB
cord-316996-8yimrpaz	198	24	with	with	IN
cord-316996-8yimrpaz	198	25	desialylation	desialylation	NN
cord-316996-8yimrpaz	198	26	(	(	-LRB-
cord-316996-8yimrpaz	198	27	Fig	Fig	NNP
cord-316996-8yimrpaz	198	28	.	.	NNP
cord-316996-8yimrpaz	198	29	2	2	CD
cord-316996-8yimrpaz	198	30	)	)	-RRB-
cord-316996-8yimrpaz	198	31	.	.	.
cord-316996-8yimrpaz	199	1	Similar	similar	JJ
cord-316996-8yimrpaz	199	2	changes	change	NNS
cord-316996-8yimrpaz	199	3	were	be	VBD
cord-316996-8yimrpaz	199	4	also	also	RB
cord-316996-8yimrpaz	199	5	seen	see	VBN
cord-316996-8yimrpaz	199	6	in	in	IN
cord-316996-8yimrpaz	199	7	freshly	freshly	RB
cord-316996-8yimrpaz	199	8	isolated	isolate	VBN
cord-316996-8yimrpaz	199	9	human	human	JJ
cord-316996-8yimrpaz	199	10	bronchial	bronchial	JJ
cord-316996-8yimrpaz	199	11	ex	ex	FW
cord-316996-8yimrpaz	199	12	vivo	vivo	NN
cord-316996-8yimrpaz	199	13	cultures	culture	NNS
cord-316996-8yimrpaz	199	14	.	.	.
cord-316996-8yimrpaz	200	1	In	in	IN
cord-316996-8yimrpaz	200	2	the	the	DT
cord-316996-8yimrpaz	200	3	HAE	HAE	NNP
cord-316996-8yimrpaz	200	4	model	model	NN
cord-316996-8yimrpaz	200	5	,	,	,
cord-316996-8yimrpaz	200	6	re	re	NN
cord-316996-8yimrpaz	200	7	-	-	NN
cord-316996-8yimrpaz	200	8	sialylation	sialylation	NN
cord-316996-8yimrpaz	200	9	was	be	VBD
cord-316996-8yimrpaz	200	10	achieved	achieve	VBN
cord-316996-8yimrpaz	200	11	by	by	IN
cord-316996-8yimrpaz	200	12	10	10	CD
cord-316996-8yimrpaz	200	13	days	day	NNS
cord-316996-8yimrpaz	200	14	,	,	,
cord-316996-8yimrpaz	200	15	whereas	whereas	IN
cord-316996-8yimrpaz	200	16	without	without	IN
cord-316996-8yimrpaz	200	17	the	the	DT
cord-316996-8yimrpaz	200	18	amphiregulin	amphiregulin	NNP
cord-316996-8yimrpaz	200	19	tag	tag	NNP
cord-316996-8yimrpaz	200	20	re	re	NNP
cord-316996-8yimrpaz	200	21	-	-	NN
cord-316996-8yimrpaz	200	22	sialylation	sialylation	NN
cord-316996-8yimrpaz	200	23	was	be	VBD
cord-316996-8yimrpaz	200	24	much	much	RB
cord-316996-8yimrpaz	200	25	faster	fast	JJR
cord-316996-8yimrpaz	200	26	.	.	.
cord-316996-8yimrpaz	201	1	A	a	DT
cord-316996-8yimrpaz	201	2	24	24	CD
cord-316996-8yimrpaz	201	3	h	h	NN
cord-316996-8yimrpaz	201	4	postexposure	postexposure	NN
cord-316996-8yimrpaz	201	5	regimen	regimen	NN
cord-316996-8yimrpaz	201	6	also	also	RB
cord-316996-8yimrpaz	201	7	produced	produce	VBD
cord-316996-8yimrpaz	201	8	a	a	DT
cord-316996-8yimrpaz	201	9	reduction	reduction	NN
cord-316996-8yimrpaz	201	10	in	in	IN
cord-316996-8yimrpaz	201	11	viral	viral	JJ
cord-316996-8yimrpaz	201	12	titre	titre	NN
cord-316996-8yimrpaz	201	13	in	in	IN
cord-316996-8yimrpaz	201	14	H1N1	H1N1	NNP
cord-316996-8yimrpaz	201	15	infection	infection	NN
cord-316996-8yimrpaz	201	16	,	,	,
cord-316996-8yimrpaz	201	17	thus	thus	RB
cord-316996-8yimrpaz	201	18	demonstrating	demonstrate	VBG
cord-316996-8yimrpaz	201	19	that	that	IN
cord-316996-8yimrpaz	201	20	DAS181	DAS181	NNP
cord-316996-8yimrpaz	201	21	could	could	MD
cord-316996-8yimrpaz	201	22	have	have	VB
cord-316996-8yimrpaz	201	23	a	a	DT
cord-316996-8yimrpaz	201	24	therapeutic	therapeutic	JJ
cord-316996-8yimrpaz	201	25	was	be	VBD
cord-316996-8yimrpaz	201	26	well	well	RB
cord-316996-8yimrpaz	201	27	as	as	IN
cord-316996-8yimrpaz	201	28	a	a	DT
cord-316996-8yimrpaz	201	29	prophylactic	prophylactic	JJ
cord-316996-8yimrpaz	201	30	role	role	NN
cord-316996-8yimrpaz	201	31	.	.	.
cord-316996-8yimrpaz	202	1	This	this	DT
cord-316996-8yimrpaz	202	2	was	be	VBD
cord-316996-8yimrpaz	202	3	also	also	RB
cord-316996-8yimrpaz	202	4	demonstrated	demonstrate	VBN
cord-316996-8yimrpaz	202	5	in	in	IN
cord-316996-8yimrpaz	202	6	an	an	DT
cord-316996-8yimrpaz	202	7	animal	animal	NN
cord-316996-8yimrpaz	202	8	model	model	NN
cord-316996-8yimrpaz	202	9	,	,	,
cord-316996-8yimrpaz	202	10	in	in	IN
cord-316996-8yimrpaz	202	11	which	which	WDT
cord-316996-8yimrpaz	202	12	treatment	treatment	NN
cord-316996-8yimrpaz	202	13	at	at	IN
cord-316996-8yimrpaz	202	14	48	48	CD
cord-316996-8yimrpaz	202	15	h	h	NN
cord-316996-8yimrpaz	202	16	postinfection	postinfection	NN
cord-316996-8yimrpaz	202	17	reduced	reduce	VBN
cord-316996-8yimrpaz	202	18	mortality	mortality	NN
cord-316996-8yimrpaz	202	19	and	and	CC
cord-316996-8yimrpaz	202	20	viral	viral	JJ
cord-316996-8yimrpaz	202	21	load	load	NN
cord-316996-8yimrpaz	202	22	in	in	IN
cord-316996-8yimrpaz	202	23	mice	mouse	NNS
cord-316996-8yimrpaz	202	24	infected	infect	VBN
cord-316996-8yimrpaz	202	25	with	with	IN
cord-316996-8yimrpaz	202	26	A	A	NNP
cord-316996-8yimrpaz	202	27	/	/	SYM
cord-316996-8yimrpaz	202	28	PR8/34(H1N1	PR8/34(H1N1	NNP
cord-316996-8yimrpaz	202	29	)	)	-RRB-
cord-316996-8yimrpaz	202	30	and	and	CC
cord-316996-8yimrpaz	202	31	A	a	DT
cord-316996-8yimrpaz	202	32	/	/	SYM
cord-316996-8yimrpaz	202	33	Victoria/3/75(H3N2	victoria/3/75(h3n2	NN
cord-316996-8yimrpaz	202	34	)	)	-RRB-
cord-316996-8yimrpaz	202	35	.	.	.
cord-316996-8yimrpaz	203	1	Additional	additional	JJ
cord-316996-8yimrpaz	203	2	studies	study	NNS
cord-316996-8yimrpaz	203	3	were	be	VBD
cord-316996-8yimrpaz	203	4	done	do	VBN
cord-316996-8yimrpaz	203	5	on	on	IN
cord-316996-8yimrpaz	203	6	lung	lung	NN
cord-316996-8yimrpaz	203	7	ex	ex	NN
cord-316996-8yimrpaz	203	8	-	-	NN
cord-316996-8yimrpaz	203	9	vivo	vivo	JJ
cord-316996-8yimrpaz	203	10	infections	infection	NNS
cord-316996-8yimrpaz	203	11	,	,	,
cord-316996-8yimrpaz	203	12	using	use	VBG
cord-316996-8yimrpaz	203	13	H5N1	H5N1	NNP
cord-316996-8yimrpaz	203	14	H1N1pdm	H1N1pdm	NNP
cord-316996-8yimrpaz	203	15	viruses	virus	NNS
cord-316996-8yimrpaz	203	16	(	(	-LRB-
cord-316996-8yimrpaz	203	17	Triana	Triana	NNP
cord-316996-8yimrpaz	203	18	-	-	HYPH
cord-316996-8yimrpaz	203	19	Baltzer	Baltzer	NNP
cord-316996-8yimrpaz	203	20	et	et	NNP
cord-316996-8yimrpaz	203	21	al	al	NNP
cord-316996-8yimrpaz	203	22	.	.	NNP
cord-316996-8yimrpaz	203	23	,	,	,
cord-316996-8yimrpaz	203	24	2009	2009	CD
cord-316996-8yimrpaz	203	25	)	)	-RRB-
cord-316996-8yimrpaz	203	26	,	,	,
cord-316996-8yimrpaz	203	27	showing	show	VBG
cord-316996-8yimrpaz	203	28	a	a	DT
cord-316996-8yimrpaz	203	29	similar	similar	JJ
cord-316996-8yimrpaz	203	30	reduction	reduction	NN
cord-316996-8yimrpaz	203	31	in	in	IN
cord-316996-8yimrpaz	203	32	viral	viral	JJ
cord-316996-8yimrpaz	203	33	infection	infection	NN
cord-316996-8yimrpaz	203	34	without	without	IN
cord-316996-8yimrpaz	203	35	toxicity	toxicity	NN
cord-316996-8yimrpaz	203	36	.	.	.
cord-316996-8yimrpaz	204	1	DAS181	DAS181	NNP
cord-316996-8yimrpaz	204	2	was	be	VBD
cord-316996-8yimrpaz	204	3	formulated	formulate	VBN
cord-316996-8yimrpaz	204	4	into	into	IN
cord-316996-8yimrpaz	204	5	dry	dry	JJ
cord-316996-8yimrpaz	204	6	-	-	HYPH
cord-316996-8yimrpaz	204	7	powder	powder	NN
cord-316996-8yimrpaz	204	8	microparticles	microparticle	NNS
cord-316996-8yimrpaz	204	9	with	with	IN
cord-316996-8yimrpaz	204	10	a	a	DT
cord-316996-8yimrpaz	204	11	diameter	diameter	NN
cord-316996-8yimrpaz	204	12	ranging	range	VBG
cord-316996-8yimrpaz	204	13	from	from	IN
cord-316996-8yimrpaz	204	14	3	3	CD
cord-316996-8yimrpaz	204	15	to	to	IN
cord-316996-8yimrpaz	204	16	6	6	CD
cord-316996-8yimrpaz	204	17	lm	lm	XX
cord-316996-8yimrpaz	204	18	using	use	VBG
cord-316996-8yimrpaz	204	19	a	a	DT
cord-316996-8yimrpaz	204	20	proprietary	proprietary	JJ
cord-316996-8yimrpaz	204	21	Temperaturecontrolled	Temperaturecontrolled	NNP
cord-316996-8yimrpaz	204	22	organic	organic	JJ
cord-316996-8yimrpaz	204	23	solvent	solvent	NN
cord-316996-8yimrpaz	204	24	assisted	assist	VBN
cord-316996-8yimrpaz	204	25	precipitation	precipitation	NN
cord-316996-8yimrpaz	204	26	(	(	-LRB-
cord-316996-8yimrpaz	204	27	TOSAP	TOSAP	NNP
cord-316996-8yimrpaz	204	28	)	)	-RRB-
cord-316996-8yimrpaz	204	29	technology	technology	NN
cord-316996-8yimrpaz	204	30	,	,	,
cord-316996-8yimrpaz	204	31	and	and	CC
cord-316996-8yimrpaz	204	32	drug	drug	NN
cord-316996-8yimrpaz	204	33	deposition	deposition	NN
cord-316996-8yimrpaz	204	34	was	be	VBD
cord-316996-8yimrpaz	204	35	tested	test	VBN
cord-316996-8yimrpaz	204	36	using	use	VBG
cord-316996-8yimrpaz	204	37	a	a	DT
cord-316996-8yimrpaz	204	38	cast	cast	NN
cord-316996-8yimrpaz	204	39	of	of	IN
cord-316996-8yimrpaz	204	40	the	the	DT
cord-316996-8yimrpaz	204	41	human	human	JJ
cord-316996-8yimrpaz	204	42	airway	airway	NN
cord-316996-8yimrpaz	204	43	.	.	.
cord-316996-8yimrpaz	205	1	As	as	IN
cord-316996-8yimrpaz	205	2	expected	expect	VBN
cord-316996-8yimrpaz	205	3	,	,	,
cord-316996-8yimrpaz	205	4	smaller	small	JJR
cord-316996-8yimrpaz	205	5	particles	particle	NNS
cord-316996-8yimrpaz	205	6	(	(	-LRB-
cord-316996-8yimrpaz	205	7	3	3	CD
cord-316996-8yimrpaz	205	8	lm	lm	NNP
cord-316996-8yimrpaz	205	9	)	)	-RRB-
cord-316996-8yimrpaz	205	10	were	be	VBD
cord-316996-8yimrpaz	205	11	associated	associate	VBN
cord-316996-8yimrpaz	205	12	with	with	IN
cord-316996-8yimrpaz	205	13	increased	increase	VBN
cord-316996-8yimrpaz	205	14	deposition	deposition	NN
cord-316996-8yimrpaz	205	15	in	in	IN
cord-316996-8yimrpaz	205	16	the	the	DT
cord-316996-8yimrpaz	205	17	deep	deep	JJ
cord-316996-8yimrpaz	205	18	lungs	lung	NNS
cord-316996-8yimrpaz	205	19	(	(	-LRB-
cord-316996-8yimrpaz	205	20	43	43	CD
cord-316996-8yimrpaz	205	21	%	%	NN
cord-316996-8yimrpaz	205	22	)	)	-RRB-
cord-316996-8yimrpaz	205	23	and	and	CC
cord-316996-8yimrpaz	205	24	higher	high	JJR
cord-316996-8yimrpaz	205	25	systemic	systemic	JJ
cord-316996-8yimrpaz	205	26	exposure	exposure	NN
cord-316996-8yimrpaz	205	27	,	,	,
cord-316996-8yimrpaz	205	28	compared	compare	VBN
cord-316996-8yimrpaz	205	29	to	to	IN
cord-316996-8yimrpaz	205	30	8.6	8.6	CD
cord-316996-8yimrpaz	205	31	%	%	NN
cord-316996-8yimrpaz	205	32	for	for	IN
cord-316996-8yimrpaz	205	33	10	10	CD
cord-316996-8yimrpaz	205	34	lm	lm	NNP
cord-316996-8yimrpaz	205	35	particles	particle	NNS
cord-316996-8yimrpaz	205	36	.	.	.
cord-316996-8yimrpaz	206	1	Using	use	VBG
cord-316996-8yimrpaz	206	2	the	the	DT
cord-316996-8yimrpaz	206	3	same	same	JJ
cord-316996-8yimrpaz	206	4	airway	airway	NN
cord-316996-8yimrpaz	206	5	model	model	NN
cord-316996-8yimrpaz	206	6	,	,	,
cord-316996-8yimrpaz	206	7	Relenza	Relenza	NNP
cord-316996-8yimrpaz	206	8	Ò	Ò	NNP
cord-316996-8yimrpaz	206	9	had	have	VBD
cord-316996-8yimrpaz	206	10	a	a	DT
cord-316996-8yimrpaz	206	11	13.2	13.2	CD
cord-316996-8yimrpaz	206	12	%	%	NN
cord-316996-8yimrpaz	206	13	deposition	deposition	NN
cord-316996-8yimrpaz	206	14	in	in	IN
cord-316996-8yimrpaz	206	15	the	the	DT
cord-316996-8yimrpaz	206	16	distal	distal	JJ
cord-316996-8yimrpaz	206	17	bronchi	bronchi	NN
cord-316996-8yimrpaz	206	18	and	and	CC
cord-316996-8yimrpaz	206	19	lungs	lung	NNS
cord-316996-8yimrpaz	206	20	(	(	-LRB-
cord-316996-8yimrpaz	206	21	data	datum	NNS
cord-316996-8yimrpaz	206	22	on	on	IN
cord-316996-8yimrpaz	206	23	Company	Company	NNP
cord-316996-8yimrpaz	206	24	file	file	NN
cord-316996-8yimrpaz	206	25	)	)	-RRB-
cord-316996-8yimrpaz	206	26	.	.	.
cord-316996-8yimrpaz	207	1	In	in	IN
cord-316996-8yimrpaz	207	2	the	the	DT
cord-316996-8yimrpaz	207	3	Phase	Phase	NNP
cord-316996-8yimrpaz	207	4	2A	2a	CD
cord-316996-8yimrpaz	207	5	trial	trial	NN
cord-316996-8yimrpaz	207	6	,	,	,
cord-316996-8yimrpaz	207	7	the	the	DT
cord-316996-8yimrpaz	207	8	6	6	CD
cord-316996-8yimrpaz	207	9	lm	lm	NNP
cord-316996-8yimrpaz	207	10	size	size	NN
cord-316996-8yimrpaz	207	11	was	be	VBD
cord-316996-8yimrpaz	207	12	used	use	VBN
cord-316996-8yimrpaz	207	13	,	,	,
cord-316996-8yimrpaz	207	14	but	but	CC
cord-316996-8yimrpaz	207	15	current	current	JJ
cord-316996-8yimrpaz	207	16	Phase	phase	NN
cord-316996-8yimrpaz	207	17	2B	2b	CD
cord-316996-8yimrpaz	207	18	clinical	clinical	JJ
cord-316996-8yimrpaz	207	19	studies	study	NNS
cord-316996-8yimrpaz	207	20	are	be	VBP
cord-316996-8yimrpaz	207	21	comparing	compare	VBG
cord-316996-8yimrpaz	207	22	6	6	CD
cord-316996-8yimrpaz	207	23	lm	lm	NNP
cord-316996-8yimrpaz	207	24	and	and	CC
cord-316996-8yimrpaz	207	25	10	10	CD
cord-316996-8yimrpaz	207	26	lm	lm	NNP
cord-316996-8yimrpaz	207	27	particles	particle	NNS
cord-316996-8yimrpaz	207	28	.	.	.
cord-316996-8yimrpaz	208	1	A	a	DT
cord-316996-8yimrpaz	208	2	single	single	JJ
cord-316996-8yimrpaz	208	3	Phase	Phase	NNP
cord-316996-8yimrpaz	208	4	II	II	NNP
cord-316996-8yimrpaz	208	5	study	study	NN
cord-316996-8yimrpaz	208	6	of	of	IN
cord-316996-8yimrpaz	208	7	DAS181	DAS181	NNP
cord-316996-8yimrpaz	208	8	has	have	VBZ
cord-316996-8yimrpaz	208	9	been	be	VBN
cord-316996-8yimrpaz	208	10	completed	complete	VBN
cord-316996-8yimrpaz	208	11	,	,	,
cord-316996-8yimrpaz	208	12	which	which	WDT
cord-316996-8yimrpaz	208	13	comprised	comprise	VBD
cord-316996-8yimrpaz	208	14	177	177	CD
cord-316996-8yimrpaz	208	15	participants	participant	NNS
cord-316996-8yimrpaz	208	16	with	with	IN
cord-316996-8yimrpaz	208	17	PCR	PCR	NNP
cord-316996-8yimrpaz	208	18	-	-	HYPH
cord-316996-8yimrpaz	208	19	confirmed	confirm	VBN
cord-316996-8yimrpaz	208	20	influenza	influenza	NN
cord-316996-8yimrpaz	208	21	.	.	.
cord-316996-8yimrpaz	209	1	The	the	DT
cord-316996-8yimrpaz	209	2	inclusion	inclusion	NN
cord-316996-8yimrpaz	209	3	criteria	criterion	NNS
cord-316996-8yimrpaz	209	4	were	be	VBD
cord-316996-8yimrpaz	209	5	:	:	:
cord-316996-8yimrpaz	209	6	male	male	JJ
cord-316996-8yimrpaz	209	7	and	and	CC
cord-316996-8yimrpaz	209	8	female	female	JJ
cord-316996-8yimrpaz	209	9	participants	participant	NNS
cord-316996-8yimrpaz	209	10	age	age	NN
cord-316996-8yimrpaz	209	11	18	18	CD
cord-316996-8yimrpaz	209	12	-	-	SYM
cord-316996-8yimrpaz	209	13	70	70	CD
cord-316996-8yimrpaz	209	14	who	who	WP
cord-316996-8yimrpaz	209	15	gave	give	VBD
cord-316996-8yimrpaz	209	16	informed	informed	JJ
cord-316996-8yimrpaz	209	17	consent	consent	NN
cord-316996-8yimrpaz	209	18	,	,	,
cord-316996-8yimrpaz	209	19	were	be	VBD
cord-316996-8yimrpaz	209	20	in	in	IN
cord-316996-8yimrpaz	209	21	generally	generally	RB
cord-316996-8yimrpaz	209	22	good	good	JJ
cord-316996-8yimrpaz	209	23	health	health	NN
cord-316996-8yimrpaz	209	24	,	,	,
cord-316996-8yimrpaz	209	25	were	be	VBD
cord-316996-8yimrpaz	209	26	febrile	febrile	JJ
cord-316996-8yimrpaz	209	27	with	with	IN
cord-316996-8yimrpaz	209	28	oral	oral	JJ
cord-316996-8yimrpaz	209	29	temperature	temperature	NN
cord-316996-8yimrpaz	209	30	>	>	XX
cord-316996-8yimrpaz	209	31	37.8	37.8	CD
cord-316996-8yimrpaz	209	32	°	°	NN
cord-316996-8yimrpaz	209	33	C	c	NN
cord-316996-8yimrpaz	209	34	or	or	CC
cord-316996-8yimrpaz	209	35	reported	report	VBD
cord-316996-8yimrpaz	209	36	temperature	temperature	NN
cord-316996-8yimrpaz	209	37	>	>	XX
cord-316996-8yimrpaz	209	38	37.8	37.8	CD
cord-316996-8yimrpaz	209	39	°	°	NN
cord-316996-8yimrpaz	209	40	C	c	NN
cord-316996-8yimrpaz	209	41	,	,	,
cord-316996-8yimrpaz	209	42	or	or	CC
cord-316996-8yimrpaz	209	43	had	have	VBD
cord-316996-8yimrpaz	209	44	felt	feel	VBN
cord-316996-8yimrpaz	209	45	'	'	``
cord-316996-8yimrpaz	209	46	'	'	``
cord-316996-8yimrpaz	209	47	feverish	feverish	JJ
cord-316996-8yimrpaz	209	48	'	'	''
cord-316996-8yimrpaz	209	49	'	'	''
cord-316996-8yimrpaz	210	1	in	in	IN
cord-316996-8yimrpaz	210	2	the	the	DT
cord-316996-8yimrpaz	210	3	past	past	JJ
cord-316996-8yimrpaz	210	4	24	24	CD
cord-316996-8yimrpaz	210	5	h	h	NN
cord-316996-8yimrpaz	210	6	,	,	,
cord-316996-8yimrpaz	210	7	and	and	CC
cord-316996-8yimrpaz	210	8	who	who	WP
cord-316996-8yimrpaz	210	9	had	have	VBD
cord-316996-8yimrpaz	210	10	one	one	CD
cord-316996-8yimrpaz	210	11	or	or	CC
cord-316996-8yimrpaz	210	12	more	more	JJR
cord-316996-8yimrpaz	210	13	respiratory	respiratory	JJ
cord-316996-8yimrpaz	210	14	(	(	-LRB-
cord-316996-8yimrpaz	210	15	cough	cough	NN
cord-316996-8yimrpaz	210	16	,	,	,
cord-316996-8yimrpaz	210	17	sore	sore	JJ
cord-316996-8yimrpaz	210	18	throat	throat	NN
cord-316996-8yimrpaz	210	19	,	,	,
cord-316996-8yimrpaz	210	20	nasal	nasal	NN
cord-316996-8yimrpaz	210	21	symptoms	symptom	NNS
cord-316996-8yimrpaz	210	22	)	)	-RRB-
cord-316996-8yimrpaz	210	23	or	or	CC
cord-316996-8yimrpaz	210	24	constitutional	constitutional	JJ
cord-316996-8yimrpaz	210	25	symptoms	symptom	NNS
cord-316996-8yimrpaz	210	26	(	(	-LRB-
cord-316996-8yimrpaz	210	27	headache	headache	NN
cord-316996-8yimrpaz	210	28	,	,	,
cord-316996-8yimrpaz	210	29	myalgia	myalgia	NN
cord-316996-8yimrpaz	210	30	,	,	,
cord-316996-8yimrpaz	210	31	sweat	sweat	NN
cord-316996-8yimrpaz	210	32	/	/	SYM
cord-316996-8yimrpaz	210	33	chills	chill	NNS
cord-316996-8yimrpaz	210	34	,	,	,
cord-316996-8yimrpaz	210	35	prostration	prostration	NN
cord-316996-8yimrpaz	210	36	)	)	-RRB-
cord-316996-8yimrpaz	210	37	.	.	.
cord-316996-8yimrpaz	211	1	There	there	EX
cord-316996-8yimrpaz	211	2	were	be	VBD
cord-316996-8yimrpaz	211	3	two	two	CD
cord-316996-8yimrpaz	211	4	treatment	treatment	NN
cord-316996-8yimrpaz	211	5	arms	arm	NNS
cord-316996-8yimrpaz	211	6	:	:	:
cord-316996-8yimrpaz	211	7	one	one	CD
cord-316996-8yimrpaz	211	8	with	with	IN
cord-316996-8yimrpaz	211	9	a	a	DT
cord-316996-8yimrpaz	211	10	single	single	JJ
cord-316996-8yimrpaz	211	11	dose	dose	NN
cord-316996-8yimrpaz	211	12	of	of	IN
cord-316996-8yimrpaz	211	13	10	10	CD
cord-316996-8yimrpaz	211	14	mg	mg	NN
cord-316996-8yimrpaz	211	15	,	,	,
cord-316996-8yimrpaz	211	16	and	and	CC
cord-316996-8yimrpaz	211	17	the	the	DT
cord-316996-8yimrpaz	211	18	second	second	JJ
cord-316996-8yimrpaz	211	19	using	use	VBG
cord-316996-8yimrpaz	211	20	10	10	CD
cord-316996-8yimrpaz	211	21	mg	mg	NNP
cord-316996-8yimrpaz	211	22	/	/	SYM
cord-316996-8yimrpaz	211	23	day	day	NN
cord-316996-8yimrpaz	211	24	over	over	IN
cord-316996-8yimrpaz	211	25	3	3	CD
cord-316996-8yimrpaz	211	26	days	day	NNS
cord-316996-8yimrpaz	211	27	.	.	.
cord-316996-8yimrpaz	212	1	The	the	DT
cord-316996-8yimrpaz	212	2	mean	mean	JJ
cord-316996-8yimrpaz	212	3	age	age	NN
cord-316996-8yimrpaz	212	4	of	of	IN
cord-316996-8yimrpaz	212	5	the	the	DT
cord-316996-8yimrpaz	212	6	patients	patient	NNS
cord-316996-8yimrpaz	212	7	in	in	IN
cord-316996-8yimrpaz	212	8	the	the	DT
cord-316996-8yimrpaz	212	9	multiple	multiple	JJ
cord-316996-8yimrpaz	212	10	-	-	HYPH
cord-316996-8yimrpaz	212	11	dose	dose	NN
cord-316996-8yimrpaz	212	12	arm	arm	NN
cord-316996-8yimrpaz	212	13	was	be	VBD
cord-316996-8yimrpaz	212	14	31.7	31.7	CD
cord-316996-8yimrpaz	212	15	years	year	NNS
cord-316996-8yimrpaz	212	16	,	,	,
cord-316996-8yimrpaz	212	17	in	in	IN
cord-316996-8yimrpaz	212	18	the	the	DT
cord-316996-8yimrpaz	212	19	single	single	JJ
cord-316996-8yimrpaz	212	20	-	-	HYPH
cord-316996-8yimrpaz	212	21	dose	dose	NN
cord-316996-8yimrpaz	212	22	arm	arm	NN
cord-316996-8yimrpaz	212	23	32.2	32.2	CD
cord-316996-8yimrpaz	212	24	years	year	NNS
cord-316996-8yimrpaz	212	25	and	and	CC
cord-316996-8yimrpaz	212	26	in	in	IN
cord-316996-8yimrpaz	212	27	the	the	DT
cord-316996-8yimrpaz	212	28	placebo	placebo	NN
cord-316996-8yimrpaz	212	29	arm	arm	NN
cord-316996-8yimrpaz	212	30	33	33	CD
cord-316996-8yimrpaz	212	31	years	year	NNS
cord-316996-8yimrpaz	212	32	,	,	,
cord-316996-8yimrpaz	212	33	with	with	IN
cord-316996-8yimrpaz	212	34	a	a	DT
cord-316996-8yimrpaz	212	35	slight	slight	JJ
cord-316996-8yimrpaz	212	36	female	female	JJ
cord-316996-8yimrpaz	212	37	predominance	predominance	NN
cord-316996-8yimrpaz	212	38	in	in	IN
cord-316996-8yimrpaz	212	39	the	the	DT
cord-316996-8yimrpaz	212	40	treatment	treatment	NN
cord-316996-8yimrpaz	212	41	arms	arm	NNS
cord-316996-8yimrpaz	212	42	.	.	.
cord-316996-8yimrpaz	213	1	Thirty	thirty	CD
cord-316996-8yimrpaz	213	2	-	-	HYPH
cord-316996-8yimrpaz	213	3	seven	seven	CD
cord-316996-8yimrpaz	213	4	percent	percent	NN
cord-316996-8yimrpaz	213	5	of	of	IN
cord-316996-8yimrpaz	213	6	the	the	DT
cord-316996-8yimrpaz	213	7	participants	participant	NNS
cord-316996-8yimrpaz	213	8	had	have	VBD
cord-316996-8yimrpaz	213	9	confirmed	confirm	VBN
cord-316996-8yimrpaz	213	10	infection	infection	NN
cord-316996-8yimrpaz	213	11	with	with	IN
cord-316996-8yimrpaz	213	12	influenza	influenza	NN
cord-316996-8yimrpaz	213	13	B	b	NN
cord-316996-8yimrpaz	213	14	,	,	,
cord-316996-8yimrpaz	213	15	33	33	CD
cord-316996-8yimrpaz	213	16	%	%	NN
cord-316996-8yimrpaz	213	17	with	with	IN
cord-316996-8yimrpaz	213	18	seasonal	seasonal	JJ
cord-316996-8yimrpaz	213	19	H3N2	H3N2	NNP
cord-316996-8yimrpaz	213	20	and	and	CC
cord-316996-8yimrpaz	213	21	29	29	CD
cord-316996-8yimrpaz	213	22	%	%	NN
cord-316996-8yimrpaz	213	23	with	with	IN
cord-316996-8yimrpaz	213	24	H1N1pdm	H1N1pdm	NNP
cord-316996-8yimrpaz	213	25	.	.	.
cord-316996-8yimrpaz	214	1	No	no	DT
cord-316996-8yimrpaz	214	2	H274Y	H274Y	NNP
cord-316996-8yimrpaz	214	3	mutations	mutation	NNS
cord-316996-8yimrpaz	214	4	were	be	VBD
cord-316996-8yimrpaz	214	5	identified	identify	VBN
cord-316996-8yimrpaz	214	6	that	that	WDT
cord-316996-8yimrpaz	214	7	would	would	MD
cord-316996-8yimrpaz	214	8	confirm	confirm	VB
cord-316996-8yimrpaz	214	9	the	the	DT
cord-316996-8yimrpaz	214	10	oseltamivir	oseltamivir	NN
cord-316996-8yimrpaz	214	11	-	-	HYPH
cord-316996-8yimrpaz	214	12	resistant	resistant	JJ
cord-316996-8yimrpaz	214	13	phenotype	phenotype	NN
cord-316996-8yimrpaz	214	14	in	in	IN
cord-316996-8yimrpaz	214	15	the	the	DT
cord-316996-8yimrpaz	214	16	H1N1	H1N1	NNP
cord-316996-8yimrpaz	214	17	subtype	subtype	NN
cord-316996-8yimrpaz	214	18	of	of	IN
cord-316996-8yimrpaz	214	19	influenza	influenza	NN
cord-316996-8yimrpaz	214	20	viruses	virus	NNS
cord-316996-8yimrpaz	214	21	.	.	.
cord-316996-8yimrpaz	215	1	The	the	DT
cord-316996-8yimrpaz	215	2	trial	trial	NN
cord-316996-8yimrpaz	215	3	was	be	VBD
cord-316996-8yimrpaz	215	4	conducted	conduct	VBN
cord-316996-8yimrpaz	215	5	over	over	IN
cord-316996-8yimrpaz	215	6	many	many	JJ
cord-316996-8yimrpaz	215	7	geographical	geographical	JJ
cord-316996-8yimrpaz	215	8	areas	area	NNS
cord-316996-8yimrpaz	215	9	,	,	,
cord-316996-8yimrpaz	215	10	thus	thus	RB
cord-316996-8yimrpaz	215	11	allowing	allow	VBG
cord-316996-8yimrpaz	215	12	an	an	DT
cord-316996-8yimrpaz	215	13	evaluation	evaluation	NN
cord-316996-8yimrpaz	215	14	of	of	IN
cord-316996-8yimrpaz	215	15	a	a	DT
cord-316996-8yimrpaz	215	16	broad	broad	JJ
cord-316996-8yimrpaz	215	17	range	range	NN
cord-316996-8yimrpaz	215	18	of	of	IN
cord-316996-8yimrpaz	215	19	commonly	commonly	RB
cord-316996-8yimrpaz	215	20	circulating	circulate	VBG
cord-316996-8yimrpaz	215	21	influenza	influenza	NN
cord-316996-8yimrpaz	215	22	viruses	virus	NNS
cord-316996-8yimrpaz	215	23	.	.	.
cord-316996-8yimrpaz	216	1	The	the	DT
cord-316996-8yimrpaz	216	2	study	study	NN
cord-316996-8yimrpaz	216	3	demonstrated	demonstrate	VBD
cord-316996-8yimrpaz	216	4	a	a	DT
cord-316996-8yimrpaz	216	5	significant	significant	JJ
cord-316996-8yimrpaz	216	6	reduction	reduction	NN
cord-316996-8yimrpaz	216	7	in	in	IN
cord-316996-8yimrpaz	216	8	viral	viral	JJ
cord-316996-8yimrpaz	216	9	load	load	NN
cord-316996-8yimrpaz	216	10	over	over	IN
cord-316996-8yimrpaz	216	11	5	5	CD
cord-316996-8yimrpaz	216	12	days	day	NNS
cord-316996-8yimrpaz	216	13	,	,	,
cord-316996-8yimrpaz	216	14	for	for	IN
cord-316996-8yimrpaz	216	15	the	the	DT
cord-316996-8yimrpaz	216	16	3	3	CD
cord-316996-8yimrpaz	216	17	day	day	NN
cord-316996-8yimrpaz	216	18	dosing	dosing	NN
cord-316996-8yimrpaz	216	19	group	group	NN
cord-316996-8yimrpaz	216	20	,	,	,
cord-316996-8yimrpaz	216	21	and	and	CC
cord-316996-8yimrpaz	216	22	a	a	DT
cord-316996-8yimrpaz	216	23	significantly	significantly	RB
cord-316996-8yimrpaz	216	24	shorter	short	JJR
cord-316996-8yimrpaz	216	25	time	time	NN
cord-316996-8yimrpaz	216	26	to	to	IN
cord-316996-8yimrpaz	216	27	sustained	sustained	JJ
cord-316996-8yimrpaz	216	28	decrease	decrease	NN
cord-316996-8yimrpaz	216	29	in	in	IN
cord-316996-8yimrpaz	216	30	viral	viral	JJ
cord-316996-8yimrpaz	216	31	shedding	shedding	NN
cord-316996-8yimrpaz	216	32	in	in	IN
cord-316996-8yimrpaz	216	33	this	this	DT
cord-316996-8yimrpaz	216	34	group	group	NN
cord-316996-8yimrpaz	216	35	,	,	,
cord-316996-8yimrpaz	216	36	compared	compare	VBN
cord-316996-8yimrpaz	216	37	to	to	IN
cord-316996-8yimrpaz	216	38	the	the	DT
cord-316996-8yimrpaz	216	39	placebo	placebo	NN
cord-316996-8yimrpaz	216	40	group	group	NN
cord-316996-8yimrpaz	216	41	.	.	.
cord-316996-8yimrpaz	217	1	The	the	DT
cord-316996-8yimrpaz	217	2	3	3	CD
cord-316996-8yimrpaz	217	3	day	day	NN
cord-316996-8yimrpaz	217	4	dose	dose	NN
cord-316996-8yimrpaz	217	5	schedule	schedule	NN
cord-316996-8yimrpaz	217	6	was	be	VBD
cord-316996-8yimrpaz	217	7	more	more	RBR
cord-316996-8yimrpaz	217	8	effective	effective	JJ
cord-316996-8yimrpaz	217	9	than	than	IN
cord-316996-8yimrpaz	217	10	the	the	DT
cord-316996-8yimrpaz	217	11	single	single	JJ
cord-316996-8yimrpaz	217	12	-	-	HYPH
cord-316996-8yimrpaz	217	13	day	day	NN
cord-316996-8yimrpaz	217	14	dose	dose	NN
cord-316996-8yimrpaz	217	15	regimen	regimen	NN
cord-316996-8yimrpaz	217	16	,	,	,
cord-316996-8yimrpaz	217	17	but	but	CC
cord-316996-8yimrpaz	217	18	no	no	DT
cord-316996-8yimrpaz	217	19	change	change	NN
cord-316996-8yimrpaz	217	20	in	in	IN
cord-316996-8yimrpaz	217	21	flu	flu	NN
cord-316996-8yimrpaz	217	22	-	-	HYPH
cord-316996-8yimrpaz	217	23	like	like	JJ
cord-316996-8yimrpaz	217	24	symptoms	symptom	NNS
cord-316996-8yimrpaz	217	25	was	be	VBD
cord-316996-8yimrpaz	217	26	seen	see	VBN
cord-316996-8yimrpaz	217	27	between	between	IN
cord-316996-8yimrpaz	217	28	the	the	DT
cord-316996-8yimrpaz	217	29	control	control	NN
cord-316996-8yimrpaz	217	30	or	or	CC
cord-316996-8yimrpaz	217	31	treatment	treatment	NN
cord-316996-8yimrpaz	217	32	groups	group	NNS
cord-316996-8yimrpaz	217	33	.	.	.
cord-316996-8yimrpaz	218	1	However	however	RB
cord-316996-8yimrpaz	218	2	,	,	,
cord-316996-8yimrpaz	218	3	the	the	DT
cord-316996-8yimrpaz	218	4	study	study	NN
cord-316996-8yimrpaz	218	5	lacked	lack	VBD
cord-316996-8yimrpaz	218	6	statistical	statistical	JJ
cord-316996-8yimrpaz	218	7	power	power	NN
cord-316996-8yimrpaz	218	8	and	and	CC
cord-316996-8yimrpaz	218	9	was	be	VBD
cord-316996-8yimrpaz	218	10	not	not	RB
cord-316996-8yimrpaz	218	11	designed	design	VBN
cord-316996-8yimrpaz	218	12	to	to	TO
cord-316996-8yimrpaz	218	13	assess	assess	VB
cord-316996-8yimrpaz	218	14	clinical	clinical	JJ
cord-316996-8yimrpaz	218	15	differences	difference	NNS
cord-316996-8yimrpaz	218	16	among	among	IN
cord-316996-8yimrpaz	218	17	the	the	DT
cord-316996-8yimrpaz	218	18	treatment	treatment	NN
cord-316996-8yimrpaz	218	19	groups	group	NNS
cord-316996-8yimrpaz	218	20	.	.	.
cord-316996-8yimrpaz	219	1	There	there	EX
cord-316996-8yimrpaz	219	2	was	be	VBD
cord-316996-8yimrpaz	219	3	a	a	DT
cord-316996-8yimrpaz	219	4	low	low	JJ
cord-316996-8yimrpaz	219	5	incidence	incidence	NN
cord-316996-8yimrpaz	219	6	of	of	IN
cord-316996-8yimrpaz	219	7	serious	serious	JJ
cord-316996-8yimrpaz	219	8	adverse	adverse	JJ
cord-316996-8yimrpaz	219	9	events	event	NNS
cord-316996-8yimrpaz	219	10	,	,	,
cord-316996-8yimrpaz	219	11	and	and	CC
cord-316996-8yimrpaz	219	12	only	only	RB
cord-316996-8yimrpaz	219	13	a	a	DT
cord-316996-8yimrpaz	219	14	mild	mild	JJ
cord-316996-8yimrpaz	219	15	increase	increase	NN
cord-316996-8yimrpaz	219	16	in	in	IN
cord-316996-8yimrpaz	219	17	serum	serum	NN
cord-316996-8yimrpaz	219	18	ALP	ALP	NNP
cord-316996-8yimrpaz	219	19	,	,	,
cord-316996-8yimrpaz	219	20	possibly	possibly	RB
cord-316996-8yimrpaz	219	21	a	a	DT
cord-316996-8yimrpaz	219	22	desialylation	desialylation	NN
cord-316996-8yimrpaz	219	23	-	-	HYPH
cord-316996-8yimrpaz	219	24	mediated	mediate	VBN
cord-316996-8yimrpaz	219	25	effect	effect	NN
cord-316996-8yimrpaz	219	26	.	.	.
cord-316996-8yimrpaz	220	1	There	there	EX
cord-316996-8yimrpaz	220	2	did	do	VBD
cord-316996-8yimrpaz	220	3	not	not	RB
cord-316996-8yimrpaz	220	4	appear	appear	VB
cord-316996-8yimrpaz	220	5	to	to	TO
cord-316996-8yimrpaz	220	6	be	be	VB
cord-316996-8yimrpaz	220	7	a	a	DT
cord-316996-8yimrpaz	220	8	reported	report	VBN
cord-316996-8yimrpaz	220	9	increase	increase	NN
cord-316996-8yimrpaz	220	10	in	in	IN
cord-316996-8yimrpaz	220	11	secondary	secondary	JJ
cord-316996-8yimrpaz	220	12	bacterial	bacterial	JJ
cord-316996-8yimrpaz	220	13	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	220	14	.	.	.
cord-316996-8yimrpaz	221	1	There	there	EX
cord-316996-8yimrpaz	221	2	are	be	VBP
cord-316996-8yimrpaz	221	3	a	a	DT
cord-316996-8yimrpaz	221	4	number	number	NN
cord-316996-8yimrpaz	221	5	of	of	IN
cord-316996-8yimrpaz	221	6	potential	potential	JJ
cord-316996-8yimrpaz	221	7	concerns	concern	NNS
cord-316996-8yimrpaz	221	8	with	with	IN
cord-316996-8yimrpaz	221	9	sialidase	sialidase	NN
cord-316996-8yimrpaz	221	10	therapy	therapy	NN
cord-316996-8yimrpaz	221	11	,	,	,
cord-316996-8yimrpaz	221	12	including	include	VBG
cord-316996-8yimrpaz	221	13	systemic	systemic	JJ
cord-316996-8yimrpaz	221	14	dissemination	dissemination	NN
cord-316996-8yimrpaz	221	15	of	of	IN
cord-316996-8yimrpaz	221	16	the	the	DT
cord-316996-8yimrpaz	221	17	drug	drug	NN
cord-316996-8yimrpaz	221	18	,	,	,
cord-316996-8yimrpaz	221	19	development	development	NN
cord-316996-8yimrpaz	221	20	of	of	IN
cord-316996-8yimrpaz	221	21	antibodies	antibody	NNS
cord-316996-8yimrpaz	221	22	and	and	CC
cord-316996-8yimrpaz	221	23	the	the	DT
cord-316996-8yimrpaz	221	24	role	role	NN
cord-316996-8yimrpaz	221	25	of	of	IN
cord-316996-8yimrpaz	221	26	secondary	secondary	JJ
cord-316996-8yimrpaz	221	27	bacterial	bacterial	JJ
cord-316996-8yimrpaz	221	28	infection	infection	NN
cord-316996-8yimrpaz	221	29	.	.	.
cord-316996-8yimrpaz	222	1	It	-PRON-	PRP
cord-316996-8yimrpaz	222	2	was	be	VBD
cord-316996-8yimrpaz	222	3	mentioned	mention	VBN
cord-316996-8yimrpaz	222	4	earlier	early	RBR
cord-316996-8yimrpaz	222	5	that	that	IN
cord-316996-8yimrpaz	222	6	A.	a.	NN
cord-316996-8yimrpaz	222	7	viscosus	viscosus	NN
cord-316996-8yimrpaz	222	8	was	be	VBD
cord-316996-8yimrpaz	222	9	chosen	choose	VBN
cord-316996-8yimrpaz	222	10	because	because	IN
cord-316996-8yimrpaz	222	11	it	-PRON-	PRP
cord-316996-8yimrpaz	222	12	is	be	VBZ
cord-316996-8yimrpaz	222	13	a	a	DT
cord-316996-8yimrpaz	222	14	natural	natural	JJ
cord-316996-8yimrpaz	222	15	commensal	commensal	NN
cord-316996-8yimrpaz	222	16	of	of	IN
cord-316996-8yimrpaz	222	17	the	the	DT
cord-316996-8yimrpaz	222	18	oral	oral	JJ
cord-316996-8yimrpaz	222	19	cavity	cavity	NN
cord-316996-8yimrpaz	222	20	,	,	,
cord-316996-8yimrpaz	222	21	and	and	CC
cord-316996-8yimrpaz	222	22	there	there	EX
cord-316996-8yimrpaz	222	23	have	have	VBP
cord-316996-8yimrpaz	222	24	been	be	VBN
cord-316996-8yimrpaz	222	25	no	no	DT
cord-316996-8yimrpaz	222	26	reported	report	VBN
cord-316996-8yimrpaz	222	27	changes	change	NNS
cord-316996-8yimrpaz	222	28	of	of	IN
cord-316996-8yimrpaz	222	29	immunity	immunity	NN
cord-316996-8yimrpaz	222	30	with	with	IN
cord-316996-8yimrpaz	222	31	exposure	exposure	NN
cord-316996-8yimrpaz	222	32	to	to	IN
cord-316996-8yimrpaz	222	33	DAS181	DAS181	NNP
cord-316996-8yimrpaz	222	34	.	.	.
cord-316996-8yimrpaz	223	1	A	a	DT
cord-316996-8yimrpaz	223	2	mild	mild	JJ
cord-316996-8yimrpaz	223	3	increase	increase	NN
cord-316996-8yimrpaz	223	4	in	in	IN
cord-316996-8yimrpaz	223	5	ALP	ALP	NNP
cord-316996-8yimrpaz	223	6	was	be	VBD
cord-316996-8yimrpaz	223	7	seen	see	VBN
cord-316996-8yimrpaz	223	8	in	in	IN
cord-316996-8yimrpaz	223	9	the	the	DT
cord-316996-8yimrpaz	223	10	Phase	Phase	NNP
cord-316996-8yimrpaz	223	11	II	II	NNP
cord-316996-8yimrpaz	223	12	study	study	NN
cord-316996-8yimrpaz	223	13	,	,	,
cord-316996-8yimrpaz	223	14	which	which	WDT
cord-316996-8yimrpaz	223	15	may	may	MD
cord-316996-8yimrpaz	223	16	be	be	VB
cord-316996-8yimrpaz	223	17	due	due	JJ
cord-316996-8yimrpaz	223	18	to	to	IN
cord-316996-8yimrpaz	223	19	systemic	systemic	JJ
cord-316996-8yimrpaz	223	20	desialylation	desialylation	NN
cord-316996-8yimrpaz	223	21	,	,	,
cord-316996-8yimrpaz	223	22	but	but	CC
cord-316996-8yimrpaz	223	23	no	no	DT
cord-316996-8yimrpaz	223	24	changes	change	NNS
cord-316996-8yimrpaz	223	25	in	in	IN
cord-316996-8yimrpaz	223	26	hematological	hematological	JJ
cord-316996-8yimrpaz	223	27	parameters	parameter	NNS
cord-316996-8yimrpaz	223	28	were	be	VBD
cord-316996-8yimrpaz	223	29	identified	identify	VBN
cord-316996-8yimrpaz	223	30	.	.	.
cord-316996-8yimrpaz	224	1	It	-PRON-	PRP
cord-316996-8yimrpaz	224	2	was	be	VBD
cord-316996-8yimrpaz	224	3	mentioned	mention	VBN
cord-316996-8yimrpaz	224	4	previously	previously	RB
cord-316996-8yimrpaz	224	5	that	that	IN
cord-316996-8yimrpaz	224	6	patients	patient	NNS
cord-316996-8yimrpaz	224	7	with	with	IN
cord-316996-8yimrpaz	224	8	influenza	influenza	NN
cord-316996-8yimrpaz	224	9	had	have	VBD
cord-316996-8yimrpaz	224	10	increased	increase	VBN
cord-316996-8yimrpaz	224	11	bacterial	bacterial	JJ
cord-316996-8yimrpaz	224	12	infection	infection	NN
cord-316996-8yimrpaz	224	13	with	with	IN
cord-316996-8yimrpaz	224	14	Pneumococcus	Pneumococcus	NNP
cord-316996-8yimrpaz	224	15	,	,	,
cord-316996-8yimrpaz	224	16	and	and	CC
cord-316996-8yimrpaz	224	17	there	there	EX
cord-316996-8yimrpaz	224	18	were	be	VBD
cord-316996-8yimrpaz	224	19	concerns	concern	NNS
cord-316996-8yimrpaz	224	20	that	that	IN
cord-316996-8yimrpaz	224	21	the	the	DT
cord-316996-8yimrpaz	224	22	same	same	JJ
cord-316996-8yimrpaz	224	23	may	may	MD
cord-316996-8yimrpaz	224	24	be	be	VB
cord-316996-8yimrpaz	224	25	found	find	VBN
cord-316996-8yimrpaz	224	26	with	with	IN
cord-316996-8yimrpaz	224	27	DAS181	DAS181	NNP
cord-316996-8yimrpaz	224	28	treatment	treatment	NN
cord-316996-8yimrpaz	224	29	(	(	-LRB-
cord-316996-8yimrpaz	224	30	Zhang	Zhang	NNP
cord-316996-8yimrpaz	224	31	,	,	,
cord-316996-8yimrpaz	224	32	2008	2008	CD
cord-316996-8yimrpaz	224	33	)	)	-RRB-
cord-316996-8yimrpaz	224	34	.	.	.
cord-316996-8yimrpaz	225	1	The	the	DT
cord-316996-8yimrpaz	225	2	interaction	interaction	NN
cord-316996-8yimrpaz	225	3	between	between	IN
cord-316996-8yimrpaz	225	4	influenza	influenza	NN
cord-316996-8yimrpaz	225	5	virus	virus	NN
cord-316996-8yimrpaz	225	6	infection	infection	NN
cord-316996-8yimrpaz	225	7	and	and	CC
cord-316996-8yimrpaz	225	8	secondary	secondary	JJ
cord-316996-8yimrpaz	225	9	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	225	10	is	be	VBZ
cord-316996-8yimrpaz	225	11	a	a	DT
cord-316996-8yimrpaz	225	12	complex	complex	JJ
cord-316996-8yimrpaz	225	13	one	one	NN
cord-316996-8yimrpaz	225	14	that	that	WDT
cord-316996-8yimrpaz	225	15	has	have	VBZ
cord-316996-8yimrpaz	225	16	been	be	VBN
cord-316996-8yimrpaz	225	17	investigated	investigate	VBN
cord-316996-8yimrpaz	225	18	by	by	IN
cord-316996-8yimrpaz	225	19	McCullers	McCullers	NNP
cord-316996-8yimrpaz	225	20	and	and	CC
cord-316996-8yimrpaz	225	21	others	other	NNS
cord-316996-8yimrpaz	225	22	(	(	-LRB-
cord-316996-8yimrpaz	225	23	Grijalva	Grijalva	NNP
cord-316996-8yimrpaz	225	24	and	and	CC
cord-316996-8yimrpaz	225	25	Griffin	Griffin	NNP
cord-316996-8yimrpaz	225	26	,	,	,
cord-316996-8yimrpaz	225	27	2012	2012	CD
cord-316996-8yimrpaz	225	28	;	;	:
cord-316996-8yimrpaz	225	29	Iverson	Iverson	NNP
cord-316996-8yimrpaz	225	30	et	et	NNP
cord-316996-8yimrpaz	225	31	al	al	NNP
cord-316996-8yimrpaz	225	32	.	.	NNP
cord-316996-8yimrpaz	225	33	,	,	,
cord-316996-8yimrpaz	225	34	2011	2011	CD
cord-316996-8yimrpaz	225	35	;	;	:
cord-316996-8yimrpaz	225	36	Karlstrom	Karlstrom	NNP
cord-316996-8yimrpaz	225	37	et	et	NNP
cord-316996-8yimrpaz	225	38	al	al	NNP
cord-316996-8yimrpaz	225	39	.	.	NNP
cord-316996-8yimrpaz	225	40	,	,	,
cord-316996-8yimrpaz	225	41	2011	2011	CD
cord-316996-8yimrpaz	225	42	)	)	-RRB-
cord-316996-8yimrpaz	225	43	.	.	.
cord-316996-8yimrpaz	226	1	Since	since	IN
cord-316996-8yimrpaz	226	2	the	the	DT
cord-316996-8yimrpaz	226	3	1918	1918	CD
cord-316996-8yimrpaz	226	4	H1N1	H1N1	NNP
cord-316996-8yimrpaz	226	5	pandemic	pandemic	NN
cord-316996-8yimrpaz	226	6	,	,	,
cord-316996-8yimrpaz	226	7	there	there	EX
cord-316996-8yimrpaz	226	8	has	have	VBZ
cord-316996-8yimrpaz	226	9	been	be	VBN
cord-316996-8yimrpaz	226	10	an	an	DT
cord-316996-8yimrpaz	226	11	association	association	NN
cord-316996-8yimrpaz	226	12	of	of	IN
cord-316996-8yimrpaz	226	13	increased	increase	VBN
cord-316996-8yimrpaz	226	14	bacterial	bacterial	JJ
cord-316996-8yimrpaz	226	15	infection	infection	NN
cord-316996-8yimrpaz	226	16	following	follow	VBG
cord-316996-8yimrpaz	226	17	influenza	influenza	NN
cord-316996-8yimrpaz	226	18	infection	infection	NN
cord-316996-8yimrpaz	226	19	.	.	.
cord-316996-8yimrpaz	227	1	The	the	DT
cord-316996-8yimrpaz	227	2	recent	recent	JJ
cord-316996-8yimrpaz	227	3	2009	2009	CD
cord-316996-8yimrpaz	227	4	H1N1	H1N1	NNP
cord-316996-8yimrpaz	227	5	pandemic	pandemic	NN
cord-316996-8yimrpaz	227	6	was	be	VBD
cord-316996-8yimrpaz	227	7	associated	associate	VBN
cord-316996-8yimrpaz	227	8	with	with	IN
cord-316996-8yimrpaz	227	9	an	an	DT
cord-316996-8yimrpaz	227	10	increase	increase	NN
cord-316996-8yimrpaz	227	11	in	in	IN
cord-316996-8yimrpaz	227	12	invasive	invasive	JJ
cord-316996-8yimrpaz	227	13	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	227	14	infection	infection	NN
cord-316996-8yimrpaz	228	1	(	(	-LRB-
cord-316996-8yimrpaz	228	2	Nelson	Nelson	NNP
cord-316996-8yimrpaz	228	3	et	et	NNP
cord-316996-8yimrpaz	228	4	al	al	NNP
cord-316996-8yimrpaz	228	5	.	.	NNP
cord-316996-8yimrpaz	228	6	,	,	,
cord-316996-8yimrpaz	228	7	2012	2012	CD
cord-316996-8yimrpaz	228	8	)	)	-RRB-
cord-316996-8yimrpaz	228	9	,	,	,
cord-316996-8yimrpaz	228	10	suggesting	suggest	VBG
cord-316996-8yimrpaz	228	11	that	that	IN
cord-316996-8yimrpaz	228	12	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	228	13	vaccination	vaccination	NN
cord-316996-8yimrpaz	228	14	should	should	MD
cord-316996-8yimrpaz	228	15	be	be	VB
cord-316996-8yimrpaz	228	16	included	include	VBN
cord-316996-8yimrpaz	228	17	as	as	IN
cord-316996-8yimrpaz	228	18	a	a	DT
cord-316996-8yimrpaz	228	19	vaccine	vaccine	NN
cord-316996-8yimrpaz	228	20	strategy	strategy	NN
cord-316996-8yimrpaz	228	21	in	in	IN
cord-316996-8yimrpaz	228	22	future	future	JJ
cord-316996-8yimrpaz	228	23	pandemics	pandemic	NNS
cord-316996-8yimrpaz	228	24	.	.	.
cord-316996-8yimrpaz	229	1	Indeed	indeed	RB
cord-316996-8yimrpaz	229	2	,	,	,
cord-316996-8yimrpaz	229	3	vaccination	vaccination	NN
cord-316996-8yimrpaz	229	4	strategies	strategy	NNS
cord-316996-8yimrpaz	229	5	using	use	VBG
cord-316996-8yimrpaz	229	6	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	229	7	vaccination	vaccination	NN
cord-316996-8yimrpaz	229	8	reduced	reduce	VBD
cord-316996-8yimrpaz	229	9	the	the	DT
cord-316996-8yimrpaz	229	10	incidence	incidence	NN
cord-316996-8yimrpaz	229	11	of	of	IN
cord-316996-8yimrpaz	229	12	influenza	influenza	NN
cord-316996-8yimrpaz	229	13	-	-	HYPH
cord-316996-8yimrpaz	229	14	associated	associate	VBN
cord-316996-8yimrpaz	229	15	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	229	16	.	.	.
cord-316996-8yimrpaz	230	1	However	however	RB
cord-316996-8yimrpaz	230	2	,	,	,
cord-316996-8yimrpaz	230	3	the	the	DT
cord-316996-8yimrpaz	230	4	link	link	NN
cord-316996-8yimrpaz	230	5	between	between	IN
cord-316996-8yimrpaz	230	6	influenza	influenza	NN
cord-316996-8yimrpaz	230	7	and	and	CC
cord-316996-8yimrpaz	230	8	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	230	9	infection	infection	NN
cord-316996-8yimrpaz	230	10	has	have	VBZ
cord-316996-8yimrpaz	230	11	been	be	VBN
cord-316996-8yimrpaz	230	12	complicated	complicate	VBN
cord-316996-8yimrpaz	230	13	by	by	IN
cord-316996-8yimrpaz	230	14	the	the	DT
cord-316996-8yimrpaz	230	15	finding	finding	NN
cord-316996-8yimrpaz	230	16	that	that	IN
cord-316996-8yimrpaz	230	17	not	not	RB
cord-316996-8yimrpaz	230	18	all	all	DT
cord-316996-8yimrpaz	230	19	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	230	20	serotypes	serotype	NNS
cord-316996-8yimrpaz	230	21	are	be	VBP
cord-316996-8yimrpaz	230	22	associated	associate	VBN
cord-316996-8yimrpaz	230	23	with	with	IN
cord-316996-8yimrpaz	230	24	secondary	secondary	JJ
cord-316996-8yimrpaz	230	25	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	230	26	,	,	,
cord-316996-8yimrpaz	230	27	and	and	CC
cord-316996-8yimrpaz	230	28	that	that	IN
cord-316996-8yimrpaz	230	29	influenza	influenza	NN
cord-316996-8yimrpaz	230	30	virus	virus	NN
cord-316996-8yimrpaz	230	31	infection	infection	NN
cord-316996-8yimrpaz	230	32	may	may	MD
cord-316996-8yimrpaz	230	33	select	select	VB
cord-316996-8yimrpaz	230	34	out	out	RP
cord-316996-8yimrpaz	230	35	and	and	CC
cord-316996-8yimrpaz	230	36	favor	favor	VB
cord-316996-8yimrpaz	230	37	the	the	DT
cord-316996-8yimrpaz	230	38	growth	growth	NN
cord-316996-8yimrpaz	230	39	of	of	IN
cord-316996-8yimrpaz	230	40	particular	particular	JJ
cord-316996-8yimrpaz	230	41	serotypes	serotype	NNS
cord-316996-8yimrpaz	230	42	(	(	-LRB-
cord-316996-8yimrpaz	230	43	McCullers	McCullers	NNP
cord-316996-8yimrpaz	230	44	et	et	NNP
cord-316996-8yimrpaz	230	45	al	al	NNP
cord-316996-8yimrpaz	230	46	.	.	NNP
cord-316996-8yimrpaz	230	47	,	,	,
cord-316996-8yimrpaz	230	48	2010	2010	CD
cord-316996-8yimrpaz	230	49	)	)	-RRB-
cord-316996-8yimrpaz	230	50	.	.	.
cord-316996-8yimrpaz	231	1	It	-PRON-	PRP
cord-316996-8yimrpaz	231	2	has	have	VBZ
cord-316996-8yimrpaz	231	3	been	be	VBN
cord-316996-8yimrpaz	231	4	proposed	propose	VBN
cord-316996-8yimrpaz	231	5	that	that	IN
cord-316996-8yimrpaz	231	6	the	the	DT
cord-316996-8yimrpaz	231	7	desialylation	desialylation	NN
cord-316996-8yimrpaz	231	8	produced	produce	VBN
cord-316996-8yimrpaz	231	9	by	by	IN
cord-316996-8yimrpaz	231	10	the	the	DT
cord-316996-8yimrpaz	231	11	viral	viral	JJ
cord-316996-8yimrpaz	231	12	neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	231	13	exposes	expose	VBZ
cord-316996-8yimrpaz	231	14	receptors	receptor	NNS
cord-316996-8yimrpaz	231	15	that	that	WDT
cord-316996-8yimrpaz	231	16	allow	allow	VBP
cord-316996-8yimrpaz	231	17	increased	increase	VBN
cord-316996-8yimrpaz	231	18	binding	bind	VBG
cord-316996-8yimrpaz	231	19	by	by	IN
cord-316996-8yimrpaz	231	20	pneumococci	pneumococcus	NNS
cord-316996-8yimrpaz	231	21	,	,	,
cord-316996-8yimrpaz	231	22	followed	follow	VBN
cord-316996-8yimrpaz	231	23	by	by	IN
cord-316996-8yimrpaz	231	24	invasion	invasion	NN
cord-316996-8yimrpaz	231	25	.	.	.
cord-316996-8yimrpaz	232	1	As	as	IN
cord-316996-8yimrpaz	232	2	we	-PRON-	PRP
cord-316996-8yimrpaz	232	3	pointed	point	VBD
cord-316996-8yimrpaz	232	4	out	out	RP
cord-316996-8yimrpaz	232	5	previously	previously	RB
cord-316996-8yimrpaz	232	6	,	,	,
cord-316996-8yimrpaz	232	7	a	a	DT
cord-316996-8yimrpaz	232	8	clear	clear	JJ
cord-316996-8yimrpaz	232	9	distinction	distinction	NN
cord-316996-8yimrpaz	232	10	needs	need	VBZ
cord-316996-8yimrpaz	232	11	to	to	TO
cord-316996-8yimrpaz	232	12	be	be	VB
cord-316996-8yimrpaz	232	13	made	make	VBN
cord-316996-8yimrpaz	232	14	between	between	IN
cord-316996-8yimrpaz	232	15	desialylation	desialylation	NN
cord-316996-8yimrpaz	232	16	in	in	IN
cord-316996-8yimrpaz	232	17	viral	viral	JJ
cord-316996-8yimrpaz	232	18	infection	infection	NN
cord-316996-8yimrpaz	232	19	and	and	CC
cord-316996-8yimrpaz	232	20	that	that	DT
cord-316996-8yimrpaz	232	21	induced	induce	VBN
cord-316996-8yimrpaz	232	22	by	by	IN
cord-316996-8yimrpaz	232	23	topical	topical	JJ
cord-316996-8yimrpaz	232	24	therapy	therapy	NN
cord-316996-8yimrpaz	233	1	(	(	-LRB-
cord-316996-8yimrpaz	233	2	Nicholls	Nicholls	NNP
cord-316996-8yimrpaz	233	3	et	et	NNP
cord-316996-8yimrpaz	233	4	al	al	NNP
cord-316996-8yimrpaz	233	5	.	.	NNP
cord-316996-8yimrpaz	233	6	,	,	,
cord-316996-8yimrpaz	233	7	2008	2008	CD
cord-316996-8yimrpaz	233	8	)	)	-RRB-
cord-316996-8yimrpaz	233	9	.	.	.
cord-316996-8yimrpaz	234	1	It	-PRON-	PRP
cord-316996-8yimrpaz	234	2	is	be	VBZ
cord-316996-8yimrpaz	234	3	therefore	therefore	RB
cord-316996-8yimrpaz	234	4	important	important	JJ
cord-316996-8yimrpaz	234	5	to	to	TO
cord-316996-8yimrpaz	234	6	study	study	VB
cord-316996-8yimrpaz	234	7	whether	whether	IN
cord-316996-8yimrpaz	234	8	sialidase	sialidase	NN
cord-316996-8yimrpaz	234	9	therapy	therapy	NN
cord-316996-8yimrpaz	234	10	will	will	MD
cord-316996-8yimrpaz	234	11	lead	lead	VB
cord-316996-8yimrpaz	234	12	to	to	IN
cord-316996-8yimrpaz	234	13	an	an	DT
cord-316996-8yimrpaz	234	14	increased	increase	VBN
cord-316996-8yimrpaz	234	15	risk	risk	NN
cord-316996-8yimrpaz	234	16	of	of	IN
cord-316996-8yimrpaz	234	17	secondary	secondary	JJ
cord-316996-8yimrpaz	234	18	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	234	19	.	.	.
cord-316996-8yimrpaz	235	1	Studies	study	NNS
cord-316996-8yimrpaz	235	2	by	by	IN
cord-316996-8yimrpaz	235	3	Hedlund	Hedlund	NNP
cord-316996-8yimrpaz	235	4	and	and	CC
cord-316996-8yimrpaz	235	5	colleagues	colleague	NNS
cord-316996-8yimrpaz	235	6	using	use	VBG
cord-316996-8yimrpaz	235	7	DAS181	DAS181	NNP
cord-316996-8yimrpaz	235	8	showed	show	VBD
cord-316996-8yimrpaz	235	9	that	that	IN
cord-316996-8yimrpaz	235	10	,	,	,
cord-316996-8yimrpaz	235	11	in	in	IN
cord-316996-8yimrpaz	235	12	contrast	contrast	NN
cord-316996-8yimrpaz	235	13	to	to	IN
cord-316996-8yimrpaz	235	14	expectations	expectation	NNS
cord-316996-8yimrpaz	235	15	,	,	,
cord-316996-8yimrpaz	235	16	desialylation	desialylation	NN
cord-316996-8yimrpaz	235	17	appeared	appear	VBD
cord-316996-8yimrpaz	235	18	to	to	TO
cord-316996-8yimrpaz	235	19	protect	protect	VB
cord-316996-8yimrpaz	235	20	mice	mouse	NNS
cord-316996-8yimrpaz	235	21	against	against	IN
cord-316996-8yimrpaz	235	22	secondary	secondary	JJ
cord-316996-8yimrpaz	235	23	bacterial	bacterial	JJ
cord-316996-8yimrpaz	235	24	colonization	colonization	NN
cord-316996-8yimrpaz	235	25	.	.	.
cord-316996-8yimrpaz	236	1	Also	also	RB
cord-316996-8yimrpaz	236	2	,	,	,
cord-316996-8yimrpaz	236	3	in	in	IN
cord-316996-8yimrpaz	236	4	a	a	DT
cord-316996-8yimrpaz	236	5	study	study	NN
cord-316996-8yimrpaz	236	6	previously	previously	RB
cord-316996-8yimrpaz	236	7	cited	cite	VBN
cord-316996-8yimrpaz	236	8	,	,	,
cord-316996-8yimrpaz	236	9	there	there	EX
cord-316996-8yimrpaz	236	10	was	be	VBD
cord-316996-8yimrpaz	236	11	no	no	DT
cord-316996-8yimrpaz	236	12	evidence	evidence	NN
cord-316996-8yimrpaz	236	13	of	of	IN
cord-316996-8yimrpaz	236	14	increased	increase	VBN
cord-316996-8yimrpaz	236	15	adherence	adherence	NN
cord-316996-8yimrpaz	236	16	of	of	IN
cord-316996-8yimrpaz	236	17	pneumococci	pneumococci	NN
cord-316996-8yimrpaz	236	18	to	to	IN
cord-316996-8yimrpaz	236	19	desialylated	desialylated	JJ
cord-316996-8yimrpaz	236	20	tracheal	tracheal	JJ
cord-316996-8yimrpaz	236	21	epithelial	epithelial	JJ
cord-316996-8yimrpaz	236	22	specimens	specimen	NNS
cord-316996-8yimrpaz	236	23	(	(	-LRB-
cord-316996-8yimrpaz	236	24	Nicholls	Nicholls	NNP
cord-316996-8yimrpaz	236	25	et	et	NNP
cord-316996-8yimrpaz	236	26	al	al	NNP
cord-316996-8yimrpaz	236	27	.	.	NNP
cord-316996-8yimrpaz	236	28	,	,	,
cord-316996-8yimrpaz	236	29	2008	2008	CD
cord-316996-8yimrpaz	236	30	)	)	-RRB-
cord-316996-8yimrpaz	236	31	.	.	.
cord-316996-8yimrpaz	237	1	The	the	DT
cord-316996-8yimrpaz	237	2	contrast	contrast	NN
cord-316996-8yimrpaz	237	3	between	between	IN
cord-316996-8yimrpaz	237	4	changes	change	NNS
cord-316996-8yimrpaz	237	5	induced	induce	VBN
cord-316996-8yimrpaz	237	6	by	by	IN
cord-316996-8yimrpaz	237	7	influenza	influenza	NN
cord-316996-8yimrpaz	237	8	virus	virus	NN
cord-316996-8yimrpaz	237	9	infection	infection	NN
cord-316996-8yimrpaz	237	10	and	and	CC
cord-316996-8yimrpaz	237	11	by	by	IN
cord-316996-8yimrpaz	237	12	topical	topical	JJ
cord-316996-8yimrpaz	237	13	desialylation	desialylation	NN
cord-316996-8yimrpaz	237	14	can	can	MD
cord-316996-8yimrpaz	237	15	be	be	VB
cord-316996-8yimrpaz	237	16	explained	explain	VBN
cord-316996-8yimrpaz	237	17	by	by	IN
cord-316996-8yimrpaz	237	18	the	the	DT
cord-316996-8yimrpaz	237	19	different	different	JJ
cord-316996-8yimrpaz	237	20	pathologies	pathology	NNS
cord-316996-8yimrpaz	237	21	:	:	:
cord-316996-8yimrpaz	237	22	influenza	influenza	NN
cord-316996-8yimrpaz	237	23	virus	virus	NN
cord-316996-8yimrpaz	237	24	infection	infection	NN
cord-316996-8yimrpaz	237	25	of	of	IN
cord-316996-8yimrpaz	237	26	an	an	DT
cord-316996-8yimrpaz	237	27	epithelial	epithelial	JJ
cord-316996-8yimrpaz	237	28	surface	surface	NN
cord-316996-8yimrpaz	237	29	causes	cause	VBZ
cord-316996-8yimrpaz	237	30	necrosis	necrosis	NN
cord-316996-8yimrpaz	237	31	and	and	CC
cord-316996-8yimrpaz	237	32	desialylation	desialylation	NN
cord-316996-8yimrpaz	237	33	,	,	,
cord-316996-8yimrpaz	237	34	while	while	IN
cord-316996-8yimrpaz	237	35	the	the	DT
cord-316996-8yimrpaz	237	36	changes	change	NNS
cord-316996-8yimrpaz	237	37	induced	induce	VBN
cord-316996-8yimrpaz	237	38	by	by	IN
cord-316996-8yimrpaz	237	39	bacterial	bacterial	JJ
cord-316996-8yimrpaz	237	40	sialidase	sialidase	NNP
cord-316996-8yimrpaz	237	41	consist	consist	VBP
cord-316996-8yimrpaz	237	42	only	only	RB
cord-316996-8yimrpaz	237	43	of	of	IN
cord-316996-8yimrpaz	237	44	desialylation	desialylation	NN
cord-316996-8yimrpaz	237	45	.	.	.
cord-316996-8yimrpaz	238	1	In	in	IN
cord-316996-8yimrpaz	238	2	a	a	DT
cord-316996-8yimrpaz	238	3	virus	virus	NN
cord-316996-8yimrpaz	238	4	infection	infection	NN
cord-316996-8yimrpaz	238	5	,	,	,
cord-316996-8yimrpaz	238	6	there	there	EX
cord-316996-8yimrpaz	238	7	is	be	VBZ
cord-316996-8yimrpaz	238	8	acute	acute	JJ
cord-316996-8yimrpaz	238	9	epithelial	epithelial	JJ
cord-316996-8yimrpaz	238	10	denudation	denudation	NN
cord-316996-8yimrpaz	238	11	and	and	CC
cord-316996-8yimrpaz	238	12	exposure	exposure	NN
cord-316996-8yimrpaz	238	13	of	of	IN
cord-316996-8yimrpaz	238	14	the	the	DT
cord-316996-8yimrpaz	238	15	basement	basement	NN
cord-316996-8yimrpaz	238	16	membrane	membrane	NN
cord-316996-8yimrpaz	238	17	,	,	,
cord-316996-8yimrpaz	238	18	allowing	allow	VBG
cord-316996-8yimrpaz	238	19	adherence	adherence	NN
cord-316996-8yimrpaz	238	20	of	of	IN
cord-316996-8yimrpaz	238	21	S.	S.	NNP
cord-316996-8yimrpaz	238	22	pneumoniae	pneumoniae	NN
cord-316996-8yimrpaz	238	23	.	.	.
cord-316996-8yimrpaz	239	1	With	with	IN
cord-316996-8yimrpaz	239	2	sialidase	sialidase	NN
cord-316996-8yimrpaz	239	3	treatment	treatment	NN
cord-316996-8yimrpaz	239	4	alone	alone	RB
cord-316996-8yimrpaz	239	5	,	,	,
cord-316996-8yimrpaz	239	6	because	because	IN
cord-316996-8yimrpaz	239	7	there	there	EX
cord-316996-8yimrpaz	239	8	is	be	VBZ
cord-316996-8yimrpaz	239	9	no	no	DT
cord-316996-8yimrpaz	239	10	cell	cell	NN
cord-316996-8yimrpaz	239	11	cytotoxicity	cytotoxicity	NN
cord-316996-8yimrpaz	239	12	or	or	CC
cord-316996-8yimrpaz	239	13	epithelial	epithelial	JJ
cord-316996-8yimrpaz	239	14	loss	loss	NN
cord-316996-8yimrpaz	239	15	,	,	,
cord-316996-8yimrpaz	239	16	there	there	EX
cord-316996-8yimrpaz	239	17	is	be	VBZ
cord-316996-8yimrpaz	239	18	no	no	DT
cord-316996-8yimrpaz	239	19	increased	increase	VBN
cord-316996-8yimrpaz	239	20	adherence	adherence	NN
cord-316996-8yimrpaz	239	21	of	of	IN
cord-316996-8yimrpaz	239	22	pneumococi	pneumococi	NN
cord-316996-8yimrpaz	239	23	.	.	.
cord-316996-8yimrpaz	240	1	As	as	IN
cord-316996-8yimrpaz	240	2	detailed	detailed	JJ
cord-316996-8yimrpaz	240	3	earlier	early	RBR
cord-316996-8yimrpaz	240	4	,	,	,
cord-316996-8yimrpaz	240	5	the	the	DT
cord-316996-8yimrpaz	240	6	Phase	Phase	NNP
cord-316996-8yimrpaz	240	7	II	II	NNP
cord-316996-8yimrpaz	240	8	clinical	clinical	JJ
cord-316996-8yimrpaz	240	9	study	study	NN
cord-316996-8yimrpaz	240	10	did	do	VBD
cord-316996-8yimrpaz	240	11	not	not	RB
cord-316996-8yimrpaz	240	12	document	document	VB
cord-316996-8yimrpaz	240	13	any	any	DT
cord-316996-8yimrpaz	240	14	increase	increase	NN
cord-316996-8yimrpaz	240	15	in	in	IN
cord-316996-8yimrpaz	240	16	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	240	17	infection	infection	NN
cord-316996-8yimrpaz	240	18	.	.	.
cord-316996-8yimrpaz	241	1	Even	even	RB
cord-316996-8yimrpaz	241	2	though	though	IN
cord-316996-8yimrpaz	241	3	influenza	influenza	NN
cord-316996-8yimrpaz	241	4	viruses	virus	NNS
cord-316996-8yimrpaz	241	5	are	be	VBP
cord-316996-8yimrpaz	241	6	one	one	CD
cord-316996-8yimrpaz	241	7	of	of	IN
cord-316996-8yimrpaz	241	8	the	the	DT
cord-316996-8yimrpaz	241	9	leading	lead	VBG
cord-316996-8yimrpaz	241	10	pathogens	pathogen	NNS
cord-316996-8yimrpaz	241	11	causing	cause	VBG
cord-316996-8yimrpaz	241	12	acute	acute	JJ
cord-316996-8yimrpaz	241	13	respiratory	respiratory	JJ
cord-316996-8yimrpaz	241	14	illness	illness	NN
cord-316996-8yimrpaz	241	15	,	,	,
cord-316996-8yimrpaz	241	16	infections	infection	NNS
cord-316996-8yimrpaz	241	17	with	with	IN
cord-316996-8yimrpaz	241	18	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	241	19	virus	virus	NNP
cord-316996-8yimrpaz	241	20	1	1	CD
cord-316996-8yimrpaz	241	21	,	,	,
cord-316996-8yimrpaz	241	22	2	2	CD
cord-316996-8yimrpaz	241	23	and	and	CC
cord-316996-8yimrpaz	241	24	3	3	CD
cord-316996-8yimrpaz	241	25	make	make	VB
cord-316996-8yimrpaz	241	26	up	up	RP
cord-316996-8yimrpaz	241	27	a	a	DT
cord-316996-8yimrpaz	241	28	significant	significant	JJ
cord-316996-8yimrpaz	241	29	proportion	proportion	NN
cord-316996-8yimrpaz	241	30	of	of	IN
cord-316996-8yimrpaz	241	31	the	the	DT
cord-316996-8yimrpaz	241	32	causative	causative	JJ
cord-316996-8yimrpaz	241	33	agents	agent	NNS
cord-316996-8yimrpaz	241	34	isolated	isolate	VBN
cord-316996-8yimrpaz	241	35	during	during	IN
cord-316996-8yimrpaz	241	36	these	these	DT
cord-316996-8yimrpaz	241	37	illnesses	illness	NNS
cord-316996-8yimrpaz	241	38	,	,	,
cord-316996-8yimrpaz	241	39	especially	especially	RB
cord-316996-8yimrpaz	241	40	in	in	IN
cord-316996-8yimrpaz	241	41	the	the	DT
cord-316996-8yimrpaz	241	42	pediatric	pediatric	JJ
cord-316996-8yimrpaz	241	43	population	population	NN
cord-316996-8yimrpaz	241	44	(	(	-LRB-
cord-316996-8yimrpaz	242	1	Weigl	Weigl	NNP
cord-316996-8yimrpaz	242	2	et	et	NNP
cord-316996-8yimrpaz	242	3	al	al	NNP
cord-316996-8yimrpaz	242	4	.	.	NNP
cord-316996-8yimrpaz	242	5	,	,	,
cord-316996-8yimrpaz	242	6	2007	2007	CD
cord-316996-8yimrpaz	242	7	)	)	-RRB-
cord-316996-8yimrpaz	242	8	.	.	.
cord-316996-8yimrpaz	243	1	Although	although	IN
cord-316996-8yimrpaz	243	2	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	243	3	viruses	virus	NNS
cord-316996-8yimrpaz	243	4	typically	typically	RB
cord-316996-8yimrpaz	243	5	cause	cause	VBP
cord-316996-8yimrpaz	243	6	bronchitis	bronchitis	NN
cord-316996-8yimrpaz	243	7	and	and	CC
cord-316996-8yimrpaz	243	8	bronchiolitis	bronchiolitis	NN
cord-316996-8yimrpaz	243	9	,	,	,
cord-316996-8yimrpaz	243	10	they	-PRON-	PRP
cord-316996-8yimrpaz	243	11	are	be	VBP
cord-316996-8yimrpaz	243	12	increasingly	increasingly	RB
cord-316996-8yimrpaz	243	13	recognized	recognize	VBN
cord-316996-8yimrpaz	243	14	as	as	IN
cord-316996-8yimrpaz	243	15	agents	agent	NNS
cord-316996-8yimrpaz	243	16	of	of	IN
cord-316996-8yimrpaz	243	17	lower	low	JJR
cord-316996-8yimrpaz	243	18	respiratory	respiratory	JJ
cord-316996-8yimrpaz	243	19	tract	tract	NN
cord-316996-8yimrpaz	243	20	disease	disease	NN
cord-316996-8yimrpaz	243	21	,	,	,
cord-316996-8yimrpaz	243	22	where	where	WRB
cord-316996-8yimrpaz	243	23	they	-PRON-	PRP
cord-316996-8yimrpaz	243	24	have	have	VBP
cord-316996-8yimrpaz	243	25	a	a	DT
cord-316996-8yimrpaz	243	26	similar	similar	JJ
cord-316996-8yimrpaz	243	27	clinical	clinical	JJ
cord-316996-8yimrpaz	243	28	presentation	presentation	NN
cord-316996-8yimrpaz	243	29	to	to	IN
cord-316996-8yimrpaz	243	30	infections	infection	NNS
cord-316996-8yimrpaz	243	31	by	by	IN
cord-316996-8yimrpaz	243	32	other	other	JJ
cord-316996-8yimrpaz	243	33	respiratory	respiratory	JJ
cord-316996-8yimrpaz	243	34	viruses	virus	NNS
cord-316996-8yimrpaz	243	35	.	.	.
cord-316996-8yimrpaz	244	1	Parainfluenza	Parainfluenza	NNP
cord-316996-8yimrpaz	244	2	viruses	virus	NNS
cord-316996-8yimrpaz	244	3	are	be	VBP
cord-316996-8yimrpaz	244	4	of	of	IN
cord-316996-8yimrpaz	244	5	increasing	increase	VBG
cord-316996-8yimrpaz	244	6	concern	concern	NN
cord-316996-8yimrpaz	244	7	in	in	IN
cord-316996-8yimrpaz	244	8	pediatric	pediatric	JJ
cord-316996-8yimrpaz	244	9	and	and	CC
cord-316996-8yimrpaz	244	10	immunocompromised	immunocompromised	JJ
cord-316996-8yimrpaz	244	11	populations	population	NNS
cord-316996-8yimrpaz	244	12	,	,	,
cord-316996-8yimrpaz	244	13	in	in	IN
cord-316996-8yimrpaz	244	14	which	which	WDT
cord-316996-8yimrpaz	244	15	they	-PRON-	PRP
cord-316996-8yimrpaz	244	16	may	may	MD
cord-316996-8yimrpaz	244	17	cause	cause	VB
cord-316996-8yimrpaz	244	18	severe	severe	JJ
cord-316996-8yimrpaz	244	19	pulmonary	pulmonary	JJ
cord-316996-8yimrpaz	244	20	disease	disease	NN
cord-316996-8yimrpaz	244	21	.	.	.
cord-316996-8yimrpaz	245	1	PIV1	PIV1	NNP
cord-316996-8yimrpaz	245	2	-	-	HYPH
cord-316996-8yimrpaz	245	3	3	3	CD
cord-316996-8yimrpaz	245	4	resemble	resemble	VBP
cord-316996-8yimrpaz	245	5	influenza	influenza	NN
cord-316996-8yimrpaz	245	6	viruses	virus	NNS
cord-316996-8yimrpaz	245	7	in	in	IN
cord-316996-8yimrpaz	245	8	using	use	VBG
cord-316996-8yimrpaz	245	9	Sia	Sia	NNP
cord-316996-8yimrpaz	245	10	as	as	IN
cord-316996-8yimrpaz	245	11	a	a	DT
cord-316996-8yimrpaz	245	12	receptor	receptor	NN
cord-316996-8yimrpaz	245	13	,	,	,
cord-316996-8yimrpaz	245	14	but	but	CC
cord-316996-8yimrpaz	245	15	binding	binding	NN
cord-316996-8yimrpaz	245	16	differs	differ	NNS
cord-316996-8yimrpaz	245	17	among	among	IN
cord-316996-8yimrpaz	245	18	strains	strain	NNS
cord-316996-8yimrpaz	245	19	(	(	-LRB-
cord-316996-8yimrpaz	245	20	Villar	Villar	NNP
cord-316996-8yimrpaz	245	21	and	and	CC
cord-316996-8yimrpaz	245	22	Barroso	Barroso	NNP
cord-316996-8yimrpaz	245	23	,	,	,
cord-316996-8yimrpaz	245	24	2006	2006	CD
cord-316996-8yimrpaz	245	25	)	)	-RRB-
cord-316996-8yimrpaz	245	26	.	.	.
cord-316996-8yimrpaz	246	1	Use	use	NN
cord-316996-8yimrpaz	246	2	of	of	IN
cord-316996-8yimrpaz	246	3	a	a	DT
cord-316996-8yimrpaz	246	4	sialylated	sialylate	VBN
cord-316996-8yimrpaz	246	5	microarray	microarray	NN
cord-316996-8yimrpaz	246	6	has	have	VBZ
cord-316996-8yimrpaz	246	7	recently	recently	RB
cord-316996-8yimrpaz	246	8	demonstrated	demonstrate	VBN
cord-316996-8yimrpaz	246	9	that	that	IN
cord-316996-8yimrpaz	246	10	hPIV1	hpiv1	PRP
cord-316996-8yimrpaz	246	11	has	have	VBZ
cord-316996-8yimrpaz	246	12	the	the	DT
cord-316996-8yimrpaz	246	13	narrowest	narrow	JJS
cord-316996-8yimrpaz	246	14	specificity	specificity	NN
cord-316996-8yimrpaz	246	15	,	,	,
cord-316996-8yimrpaz	246	16	binding	bind	VBG
cord-316996-8yimrpaz	246	17	to	to	IN
cord-316996-8yimrpaz	246	18	Neu5Ac	Neu5Ac	NNP
cord-316996-8yimrpaz	246	19	,	,	,
cord-316996-8yimrpaz	246	20	but	but	CC
cord-316996-8yimrpaz	246	21	stronger	strong	JJR
cord-316996-8yimrpaz	246	22	binding	binding	NN
cord-316996-8yimrpaz	246	23	to	to	IN
cord-316996-8yimrpaz	246	24	Neu5Gc	Neu5Gc	NNP
cord-316996-8yimrpaz	246	25	with	with	IN
cord-316996-8yimrpaz	246	26	a	a	DT
cord-316996-8yimrpaz	246	27	methylated	methylated	JJ
cord-316996-8yimrpaz	246	28	derivative	derivative	NN
cord-316996-8yimrpaz	246	29	.	.	.
cord-316996-8yimrpaz	247	1	In	in	IN
cord-316996-8yimrpaz	247	2	contrast	contrast	NN
cord-316996-8yimrpaz	247	3	,	,	,
cord-316996-8yimrpaz	247	4	hPIV2	hPIV2	NNP
cord-316996-8yimrpaz	247	5	showed	show	VBD
cord-316996-8yimrpaz	247	6	a	a	DT
cord-316996-8yimrpaz	247	7	broader	broad	JJR
cord-316996-8yimrpaz	247	8	range	range	NN
cord-316996-8yimrpaz	247	9	of	of	IN
cord-316996-8yimrpaz	247	10	binding	bind	VBG
cord-316996-8yimrpaz	247	11	to	to	IN
cord-316996-8yimrpaz	247	12	Neu5Ac	Neu5Ac	NNP
cord-316996-8yimrpaz	248	1	and	and	CC
cord-316996-8yimrpaz	248	2	Neu5Gc	Neu5Gc	NNP
cord-316996-8yimrpaz	248	3	derivatives	derivative	NNS
cord-316996-8yimrpaz	248	4	,	,	,
cord-316996-8yimrpaz	248	5	while	while	IN
cord-316996-8yimrpaz	248	6	hPIV3	hPIV3	NNP
cord-316996-8yimrpaz	248	7	showed	show	VBD
cord-316996-8yimrpaz	248	8	a	a	DT
cord-316996-8yimrpaz	248	9	similar	similar	JJ
cord-316996-8yimrpaz	248	10	range	range	NN
cord-316996-8yimrpaz	248	11	of	of	IN
cord-316996-8yimrpaz	248	12	binding	binding	NN
cord-316996-8yimrpaz	248	13	,	,	,
cord-316996-8yimrpaz	248	14	but	but	CC
cord-316996-8yimrpaz	248	15	at	at	IN
cord-316996-8yimrpaz	248	16	a	a	DT
cord-316996-8yimrpaz	248	17	much	much	RB
cord-316996-8yimrpaz	248	18	lower	low	JJR
cord-316996-8yimrpaz	248	19	magnitude	magnitude	NN
cord-316996-8yimrpaz	248	20	than	than	IN
cord-316996-8yimrpaz	248	21	hPIV2	hpiv2	NN
cord-316996-8yimrpaz	248	22	.	.	.
cord-316996-8yimrpaz	249	1	All	all	DT
cord-316996-8yimrpaz	249	2	three	three	CD
cord-316996-8yimrpaz	249	3	strains	strain	NNS
cord-316996-8yimrpaz	249	4	preferentially	preferentially	RB
cord-316996-8yimrpaz	249	5	bound	bind	VBN
cord-316996-8yimrpaz	249	6	glycans	glycan	NNS
cord-316996-8yimrpaz	249	7	with	with	IN
cord-316996-8yimrpaz	249	8	an	an	DT
cord-316996-8yimrpaz	249	9	a2	a2	NN
cord-316996-8yimrpaz	249	10	-	-	HYPH
cord-316996-8yimrpaz	249	11	3	3	CD
cord-316996-8yimrpaz	249	12	,	,	,
cord-316996-8yimrpaz	249	13	rather	rather	RB
cord-316996-8yimrpaz	249	14	than	than	IN
cord-316996-8yimrpaz	249	15	an	an	DT
cord-316996-8yimrpaz	249	16	a2	a2	NN
cord-316996-8yimrpaz	249	17	-	-	SYM
cord-316996-8yimrpaz	249	18	6	6	CD
cord-316996-8yimrpaz	249	19	linkage	linkage	NN
cord-316996-8yimrpaz	249	20	(	(	-LRB-
cord-316996-8yimrpaz	249	21	Song	Song	NNP
cord-316996-8yimrpaz	249	22	et	et	FW
cord-316996-8yimrpaz	249	23	al	al	NNP
cord-316996-8yimrpaz	249	24	.	.	NNP
cord-316996-8yimrpaz	249	25	,	,	,
cord-316996-8yimrpaz	249	26	2011	2011	CD
cord-316996-8yimrpaz	249	27	)	)	-RRB-
cord-316996-8yimrpaz	249	28	.	.	.
cord-316996-8yimrpaz	250	1	The	the	DT
cord-316996-8yimrpaz	250	2	mechanism	mechanism	NN
cord-316996-8yimrpaz	250	3	of	of	IN
cord-316996-8yimrpaz	250	4	binding	binding	NN
cord-316996-8yimrpaz	250	5	and	and	CC
cord-316996-8yimrpaz	250	6	release	release	NN
cord-316996-8yimrpaz	250	7	of	of	IN
cord-316996-8yimrpaz	250	8	PIV	PIV	NNP
cord-316996-8yimrpaz	250	9	differs	differ	VBZ
cord-316996-8yimrpaz	250	10	from	from	IN
cord-316996-8yimrpaz	250	11	influenza	influenza	NN
cord-316996-8yimrpaz	250	12	viruses	virus	NNS
cord-316996-8yimrpaz	250	13	,	,	,
cord-316996-8yimrpaz	250	14	as	as	IN
cord-316996-8yimrpaz	250	15	they	-PRON-	PRP
cord-316996-8yimrpaz	250	16	have	have	VBP
cord-316996-8yimrpaz	250	17	a	a	DT
cord-316996-8yimrpaz	250	18	different	different	JJ
cord-316996-8yimrpaz	250	19	replication	replication	NN
cord-316996-8yimrpaz	250	20	pathway	pathway	NN
cord-316996-8yimrpaz	250	21	,	,	,
cord-316996-8yimrpaz	250	22	and	and	CC
cord-316996-8yimrpaz	250	23	thus	thus	RB
cord-316996-8yimrpaz	250	24	may	may	MD
cord-316996-8yimrpaz	250	25	not	not	RB
cord-316996-8yimrpaz	250	26	be	be	VB
cord-316996-8yimrpaz	250	27	amenable	amenable	JJ
cord-316996-8yimrpaz	250	28	to	to	IN
cord-316996-8yimrpaz	250	29	standard	standard	JJ
cord-316996-8yimrpaz	250	30	anti	anti	JJ
cord-316996-8yimrpaz	250	31	-	-	JJ
cord-316996-8yimrpaz	250	32	influenza	influenza	JJ
cord-316996-8yimrpaz	250	33	therapy	therapy	NN
cord-316996-8yimrpaz	250	34	.	.	.
cord-316996-8yimrpaz	251	1	Thus	thus	RB
cord-316996-8yimrpaz	251	2	,	,	,
cord-316996-8yimrpaz	251	3	although	although	IN
cord-316996-8yimrpaz	251	4	zanamivir	zanamivir	NNP
cord-316996-8yimrpaz	251	5	inhibited	inhibit	VBD
cord-316996-8yimrpaz	251	6	PIV	PIV	NNP
cord-316996-8yimrpaz	251	7	neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	251	8	activity	activity	NN
cord-316996-8yimrpaz	251	9	,	,	,
cord-316996-8yimrpaz	251	10	it	-PRON-	PRP
cord-316996-8yimrpaz	251	11	did	do	VBD
cord-316996-8yimrpaz	251	12	not	not	RB
cord-316996-8yimrpaz	251	13	prevent	prevent	VB
cord-316996-8yimrpaz	251	14	release	release	NN
cord-316996-8yimrpaz	251	15	of	of	IN
cord-316996-8yimrpaz	251	16	virus	virus	NN
cord-316996-8yimrpaz	251	17	from	from	IN
cord-316996-8yimrpaz	251	18	the	the	DT
cord-316996-8yimrpaz	251	19	cell	cell	NN
cord-316996-8yimrpaz	251	20	(	(	-LRB-
cord-316996-8yimrpaz	251	21	Moscona	Moscona	NNP
cord-316996-8yimrpaz	251	22	,	,	,
cord-316996-8yimrpaz	251	23	2005	2005	CD
cord-316996-8yimrpaz	251	24	;	;	:
cord-316996-8yimrpaz	252	1	Porotto	Porotto	NNP
cord-316996-8yimrpaz	252	2	et	et	NNP
cord-316996-8yimrpaz	252	3	al	al	NNP
cord-316996-8yimrpaz	252	4	.	.	NNP
cord-316996-8yimrpaz	252	5	,	,	,
cord-316996-8yimrpaz	252	6	2001	2001	CD
cord-316996-8yimrpaz	252	7	)	)	-RRB-
cord-316996-8yimrpaz	252	8	.	.	.
cord-316996-8yimrpaz	253	1	As	as	IN
cord-316996-8yimrpaz	253	2	the	the	DT
cord-316996-8yimrpaz	253	3	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	253	4	viruses	virus	NNS
cord-316996-8yimrpaz	253	5	use	use	VBP
cord-316996-8yimrpaz	253	6	a2	a2	NNP
cord-316996-8yimrpaz	253	7	-	-	HYPH
cord-316996-8yimrpaz	253	8	3	3	CD
cord-316996-8yimrpaz	253	9	and	and	CC
cord-316996-8yimrpaz	253	10	a2	a2	NNP
cord-316996-8yimrpaz	253	11	-	-	HYPH
cord-316996-8yimrpaz	253	12	6	6	CD
cord-316996-8yimrpaz	253	13	bound	bind	VBN
cord-316996-8yimrpaz	253	14	Sia	Sia	NNP
cord-316996-8yimrpaz	253	15	for	for	IN
cord-316996-8yimrpaz	253	16	attachment	attachment	NN
cord-316996-8yimrpaz	253	17	,	,	,
cord-316996-8yimrpaz	253	18	infection	infection	NN
cord-316996-8yimrpaz	253	19	with	with	IN
cord-316996-8yimrpaz	253	20	these	these	DT
cord-316996-8yimrpaz	253	21	viruses	virus	NNS
cord-316996-8yimrpaz	253	22	could	could	MD
cord-316996-8yimrpaz	253	23	be	be	VB
cord-316996-8yimrpaz	253	24	amenable	amenable	JJ
cord-316996-8yimrpaz	253	25	to	to	IN
cord-316996-8yimrpaz	253	26	sialidase	sialidase	NN
cord-316996-8yimrpaz	253	27	treatment	treatment	NN
cord-316996-8yimrpaz	253	28	.	.	.
cord-316996-8yimrpaz	254	1	Even	even	RB
cord-316996-8yimrpaz	254	2	though	though	IN
cord-316996-8yimrpaz	254	3	most	most	JJS
cord-316996-8yimrpaz	254	4	studies	study	NNS
cord-316996-8yimrpaz	254	5	utilizing	utilize	VBG
cord-316996-8yimrpaz	254	6	DAS181	DAS181	NNP
cord-316996-8yimrpaz	254	7	have	have	VBP
cord-316996-8yimrpaz	254	8	used	use	VBN
cord-316996-8yimrpaz	254	9	influenza	influenza	NN
cord-316996-8yimrpaz	254	10	A	a	NN
cord-316996-8yimrpaz	254	11	as	as	IN
cord-316996-8yimrpaz	254	12	a	a	DT
cord-316996-8yimrpaz	254	13	target	target	NN
cord-316996-8yimrpaz	254	14	,	,	,
cord-316996-8yimrpaz	254	15	it	-PRON-	PRP
cord-316996-8yimrpaz	254	16	has	have	VBZ
cord-316996-8yimrpaz	254	17	also	also	RB
cord-316996-8yimrpaz	254	18	been	be	VBN
cord-316996-8yimrpaz	254	19	used	use	VBN
cord-316996-8yimrpaz	254	20	in	in	IN
cord-316996-8yimrpaz	254	21	patients	patient	NNS
cord-316996-8yimrpaz	254	22	with	with	IN
cord-316996-8yimrpaz	254	23	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	254	24	.	.	.
cord-316996-8yimrpaz	255	1	In	in	IN
cord-316996-8yimrpaz	255	2	an	an	DT
cord-316996-8yimrpaz	255	3	experimental	experimental	JJ
cord-316996-8yimrpaz	255	4	setting	setting	NN
cord-316996-8yimrpaz	255	5	,	,	,
cord-316996-8yimrpaz	255	6	DAS181	DAS181	NNP
cord-316996-8yimrpaz	255	7	treatment	treatment	NN
cord-316996-8yimrpaz	255	8	of	of	IN
cord-316996-8yimrpaz	255	9	human	human	JJ
cord-316996-8yimrpaz	255	10	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	255	11	virus	virus	NN
cord-316996-8yimrpaz	255	12	-	-	HYPH
cord-316996-8yimrpaz	255	13	permissive	permissive	JJ
cord-316996-8yimrpaz	255	14	cell	cell	NN
cord-316996-8yimrpaz	255	15	lines	line	NNS
cord-316996-8yimrpaz	255	16	and	and	CC
cord-316996-8yimrpaz	255	17	of	of	IN
cord-316996-8yimrpaz	255	18	infected	infected	JJ
cord-316996-8yimrpaz	255	19	cotton	cotton	NN
cord-316996-8yimrpaz	255	20	rats	rat	NNS
cord-316996-8yimrpaz	255	21	led	lead	VBD
cord-316996-8yimrpaz	255	22	to	to	IN
cord-316996-8yimrpaz	255	23	effective	effective	JJ
cord-316996-8yimrpaz	255	24	desialylation	desialylation	NN
cord-316996-8yimrpaz	255	25	and	and	CC
cord-316996-8yimrpaz	255	26	reduced	reduce	VBN
cord-316996-8yimrpaz	255	27	infection	infection	NN
cord-316996-8yimrpaz	256	1	(	(	-LRB-
cord-316996-8yimrpaz	256	2	Moscona	Moscona	NNP
cord-316996-8yimrpaz	256	3	et	et	NNP
cord-316996-8yimrpaz	256	4	al	al	NNP
cord-316996-8yimrpaz	256	5	.	.	NNP
cord-316996-8yimrpaz	256	6	,	,	,
cord-316996-8yimrpaz	256	7	2010	2010	CD
cord-316996-8yimrpaz	256	8	)	)	-RRB-
cord-316996-8yimrpaz	256	9	.	.	.
cord-316996-8yimrpaz	257	1	DAS181	DAS181	NNP
cord-316996-8yimrpaz	257	2	has	have	VBZ
cord-316996-8yimrpaz	257	3	also	also	RB
cord-316996-8yimrpaz	257	4	been	be	VBN
cord-316996-8yimrpaz	257	5	used	use	VBN
cord-316996-8yimrpaz	257	6	on	on	IN
cord-316996-8yimrpaz	257	7	a	a	DT
cord-316996-8yimrpaz	257	8	compassionate	compassionate	JJ
cord-316996-8yimrpaz	257	9	,	,	,
cord-316996-8yimrpaz	257	10	emergency	emergency	NN
cord-316996-8yimrpaz	257	11	basis	basis	NN
cord-316996-8yimrpaz	257	12	in	in	IN
cord-316996-8yimrpaz	257	13	immunocompromised	immunocompromised	JJ
cord-316996-8yimrpaz	257	14	patients	patient	NNS
cord-316996-8yimrpaz	257	15	infected	infect	VBN
cord-316996-8yimrpaz	257	16	with	with	IN
cord-316996-8yimrpaz	257	17	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	257	18	virus	virus	NNP
cord-316996-8yimrpaz	257	19	,	,	,
cord-316996-8yimrpaz	257	20	with	with	IN
cord-316996-8yimrpaz	257	21	a	a	DT
cord-316996-8yimrpaz	257	22	beneficial	beneficial	JJ
cord-316996-8yimrpaz	257	23	effect	effect	NN
cord-316996-8yimrpaz	257	24	.	.	.
cord-316996-8yimrpaz	258	1	The	the	DT
cord-316996-8yimrpaz	258	2	first	first	JJ
cord-316996-8yimrpaz	258	3	case	case	NN
cord-316996-8yimrpaz	258	4	was	be	VBD
cord-316996-8yimrpaz	258	5	a	a	DT
cord-316996-8yimrpaz	258	6	63	63	CD
cord-316996-8yimrpaz	258	7	year	year	NN
cord-316996-8yimrpaz	258	8	old	old	JJ
cord-316996-8yimrpaz	258	9	female	female	JJ
cord-316996-8yimrpaz	258	10	stem	stem	NN
cord-316996-8yimrpaz	258	11	cell	cell	NN
cord-316996-8yimrpaz	258	12	transplant	transplant	NN
cord-316996-8yimrpaz	258	13	recipient	recipient	NN
cord-316996-8yimrpaz	258	14	who	who	WP
cord-316996-8yimrpaz	258	15	developed	develop	VBD
cord-316996-8yimrpaz	258	16	nasal	nasal	NN
cord-316996-8yimrpaz	258	17	congestion	congestion	NN
cord-316996-8yimrpaz	258	18	and	and	CC
cord-316996-8yimrpaz	258	19	cough	cough	NN
cord-316996-8yimrpaz	258	20	,	,	,
cord-316996-8yimrpaz	258	21	followed	follow	VBN
cord-316996-8yimrpaz	258	22	by	by	IN
cord-316996-8yimrpaz	258	23	clinical	clinical	JJ
cord-316996-8yimrpaz	258	24	and	and	CC
cord-316996-8yimrpaz	258	25	radiological	radiological	JJ
cord-316996-8yimrpaz	258	26	features	feature	NNS
cord-316996-8yimrpaz	258	27	of	of	IN
cord-316996-8yimrpaz	258	28	viral	viral	JJ
cord-316996-8yimrpaz	258	29	bronchiolitis	bronchiolitis	NN
cord-316996-8yimrpaz	258	30	and	and	CC
cord-316996-8yimrpaz	258	31	worsening	worsen	VBG
cord-316996-8yimrpaz	258	32	respiratory	respiratory	JJ
cord-316996-8yimrpaz	258	33	function	function	NN
cord-316996-8yimrpaz	258	34	.	.	.
cord-316996-8yimrpaz	259	1	She	-PRON-	PRP
cord-316996-8yimrpaz	259	2	received	receive	VBD
cord-316996-8yimrpaz	259	3	three	three	CD
cord-316996-8yimrpaz	259	4	daily	daily	JJ
cord-316996-8yimrpaz	259	5	inhaled	inhale	VBN
cord-316996-8yimrpaz	259	6	administrations	administration	NNS
cord-316996-8yimrpaz	259	7	of	of	IN
cord-316996-8yimrpaz	259	8	DAS181	DAS181	NNP
cord-316996-8yimrpaz	259	9	using	use	VBG
cord-316996-8yimrpaz	259	10	a	a	DT
cord-316996-8yimrpaz	259	11	dry	dry	JJ
cord-316996-8yimrpaz	259	12	powder	powder	NN
cord-316996-8yimrpaz	259	13	inhaler	inhaler	NN
cord-316996-8yimrpaz	259	14	,	,	,
cord-316996-8yimrpaz	259	15	and	and	CC
cord-316996-8yimrpaz	259	16	showed	show	VBD
cord-316996-8yimrpaz	259	17	improvement	improvement	NN
cord-316996-8yimrpaz	259	18	in	in	IN
cord-316996-8yimrpaz	259	19	clinical	clinical	JJ
cord-316996-8yimrpaz	259	20	,	,	,
cord-316996-8yimrpaz	259	21	radiological	radiological	JJ
cord-316996-8yimrpaz	259	22	and	and	CC
cord-316996-8yimrpaz	259	23	pulmonary	pulmonary	JJ
cord-316996-8yimrpaz	259	24	function	function	NN
cord-316996-8yimrpaz	259	25	parameters	parameter	NNS
cord-316996-8yimrpaz	259	26	after	after	IN
cord-316996-8yimrpaz	259	27	treatment	treatment	NN
cord-316996-8yimrpaz	259	28	.	.	.
cord-316996-8yimrpaz	260	1	PIV3	PIV3	NNP
cord-316996-8yimrpaz	260	2	infection	infection	NN
cord-316996-8yimrpaz	260	3	was	be	VBD
cord-316996-8yimrpaz	260	4	confirmed	confirm	VBN
cord-316996-8yimrpaz	260	5	,	,	,
cord-316996-8yimrpaz	260	6	and	and	CC
cord-316996-8yimrpaz	260	7	there	there	EX
cord-316996-8yimrpaz	260	8	was	be	VBD
cord-316996-8yimrpaz	260	9	a	a	DT
cord-316996-8yimrpaz	260	10	reduction	reduction	NN
cord-316996-8yimrpaz	260	11	in	in	IN
cord-316996-8yimrpaz	260	12	viral	viral	JJ
cord-316996-8yimrpaz	260	13	load	load	NN
cord-316996-8yimrpaz	260	14	after	after	IN
cord-316996-8yimrpaz	260	15	treatment	treatment	NN
cord-316996-8yimrpaz	260	16	.	.	.
cord-316996-8yimrpaz	261	1	In	in	IN
cord-316996-8yimrpaz	261	2	another	another	DT
cord-316996-8yimrpaz	261	3	report	report	NN
cord-316996-8yimrpaz	261	4	,	,	,
cord-316996-8yimrpaz	261	5	two	two	CD
cord-316996-8yimrpaz	261	6	immunocompromised	immunocompromised	JJ
cord-316996-8yimrpaz	261	7	lung	lung	NN
cord-316996-8yimrpaz	261	8	or	or	CC
cord-316996-8yimrpaz	261	9	stem	stem	NN
cord-316996-8yimrpaz	261	10	cell	cell	NN
cord-316996-8yimrpaz	261	11	transplant	transplant	NN
cord-316996-8yimrpaz	261	12	recipients	recipient	NNS
cord-316996-8yimrpaz	261	13	who	who	WP
cord-316996-8yimrpaz	261	14	developed	develop	VBD
cord-316996-8yimrpaz	261	15	PIV3	PIV3	NNP
cord-316996-8yimrpaz	261	16	infection	infection	NN
cord-316996-8yimrpaz	261	17	were	be	VBD
cord-316996-8yimrpaz	261	18	successfully	successfully	RB
cord-316996-8yimrpaz	261	19	treated	treat	VBN
cord-316996-8yimrpaz	261	20	after	after	IN
cord-316996-8yimrpaz	261	21	developing	develop	VBG
cord-316996-8yimrpaz	261	22	lower	low	JJR
cord-316996-8yimrpaz	261	23	respiratory	respiratory	JJ
cord-316996-8yimrpaz	261	24	tract	tract	NN
cord-316996-8yimrpaz	261	25	disease	disease	NN
cord-316996-8yimrpaz	261	26	.	.	.
cord-316996-8yimrpaz	262	1	In	in	IN
cord-316996-8yimrpaz	262	2	these	these	DT
cord-316996-8yimrpaz	262	3	cases	case	NNS
cord-316996-8yimrpaz	262	4	,	,	,
cord-316996-8yimrpaz	262	5	there	there	EX
cord-316996-8yimrpaz	262	6	was	be	VBD
cord-316996-8yimrpaz	262	7	a	a	DT
cord-316996-8yimrpaz	262	8	5	5	CD
cord-316996-8yimrpaz	262	9	day	day	NN
cord-316996-8yimrpaz	262	10	treatment	treatment	NN
cord-316996-8yimrpaz	262	11	with	with	IN
cord-316996-8yimrpaz	262	12	improvement	improvement	NN
cord-316996-8yimrpaz	262	13	in	in	IN
cord-316996-8yimrpaz	262	14	clinical	clinical	JJ
cord-316996-8yimrpaz	262	15	symptoms	symptom	NNS
cord-316996-8yimrpaz	262	16	and	and	CC
cord-316996-8yimrpaz	262	17	respiratory	respiratory	JJ
cord-316996-8yimrpaz	262	18	function	function	NN
cord-316996-8yimrpaz	262	19	,	,	,
cord-316996-8yimrpaz	262	20	though	though	IN
cord-316996-8yimrpaz	262	21	changes	change	NNS
cord-316996-8yimrpaz	262	22	in	in	IN
cord-316996-8yimrpaz	262	23	quantitative	quantitative	JJ
cord-316996-8yimrpaz	262	24	viral	viral	JJ
cord-316996-8yimrpaz	262	25	load	load	NN
cord-316996-8yimrpaz	262	26	did	do	VBD
cord-316996-8yimrpaz	262	27	not	not	RB
cord-316996-8yimrpaz	262	28	match	match	VB
cord-316996-8yimrpaz	262	29	the	the	DT
cord-316996-8yimrpaz	262	30	clinical	clinical	JJ
cord-316996-8yimrpaz	262	31	findings	finding	NNS
cord-316996-8yimrpaz	262	32	(	(	-LRB-
cord-316996-8yimrpaz	262	33	Guzman	Guzman	NNP
cord-316996-8yimrpaz	262	34	-	-	HYPH
cord-316996-8yimrpaz	262	35	Suarez	Suarez	NNP
cord-316996-8yimrpaz	262	36	et	et	NNP
cord-316996-8yimrpaz	262	37	al	al	NNP
cord-316996-8yimrpaz	262	38	.	.	NNP
cord-316996-8yimrpaz	262	39	,	,	,
cord-316996-8yimrpaz	262	40	2012	2012	CD
cord-316996-8yimrpaz	262	41	)	)	-RRB-
cord-316996-8yimrpaz	262	42	.	.	.
cord-316996-8yimrpaz	263	1	However	however	RB
cord-316996-8yimrpaz	263	2	,	,	,
cord-316996-8yimrpaz	263	3	a	a	DT
cord-316996-8yimrpaz	263	4	more	more	RBR
cord-316996-8yimrpaz	263	5	recent	recent	JJ
cord-316996-8yimrpaz	263	6	case	case	NN
cord-316996-8yimrpaz	263	7	of	of	IN
cord-316996-8yimrpaz	263	8	DAS181	DAS181	NNP
cord-316996-8yimrpaz	263	9	treatment	treatment	NN
cord-316996-8yimrpaz	263	10	of	of	IN
cord-316996-8yimrpaz	263	11	PIV3	PIV3	NNP
cord-316996-8yimrpaz	263	12	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	263	13	in	in	IN
cord-316996-8yimrpaz	263	14	a	a	DT
cord-316996-8yimrpaz	263	15	lung	lung	NN
cord-316996-8yimrpaz	263	16	transplant	transplant	NN
cord-316996-8yimrpaz	263	17	patient	patient	NN
cord-316996-8yimrpaz	263	18	was	be	VBD
cord-316996-8yimrpaz	263	19	associated	associate	VBN
cord-316996-8yimrpaz	263	20	with	with	IN
cord-316996-8yimrpaz	263	21	both	both	DT
cord-316996-8yimrpaz	263	22	clinical	clinical	JJ
cord-316996-8yimrpaz	263	23	improvement	improvement	NN
cord-316996-8yimrpaz	263	24	and	and	CC
cord-316996-8yimrpaz	263	25	reduction	reduction	NN
cord-316996-8yimrpaz	263	26	in	in	IN
cord-316996-8yimrpaz	263	27	viral	viral	JJ
cord-316996-8yimrpaz	263	28	load	load	NN
cord-316996-8yimrpaz	263	29	(	(	-LRB-
cord-316996-8yimrpaz	263	30	Drozd	Drozd	NNP
cord-316996-8yimrpaz	263	31	et	et	FW
cord-316996-8yimrpaz	263	32	al	al	NNP
cord-316996-8yimrpaz	263	33	.	.	NNP
cord-316996-8yimrpaz	263	34	,	,	,
cord-316996-8yimrpaz	263	35	2012	2012	CD
cord-316996-8yimrpaz	263	36	)	)	-RRB-
cord-316996-8yimrpaz	263	37	.	.	.
cord-316996-8yimrpaz	264	1	A	a	DT
cord-316996-8yimrpaz	264	2	novel	novel	JJ
cord-316996-8yimrpaz	264	3	bacterial	bacterial	JJ
cord-316996-8yimrpaz	264	4	sialidase	sialidase	NN
cord-316996-8yimrpaz	264	5	,	,	,
cord-316996-8yimrpaz	264	6	DAS181	DAS181	NNP
cord-316996-8yimrpaz	264	7	,	,	,
cord-316996-8yimrpaz	264	8	has	have	VBZ
cord-316996-8yimrpaz	264	9	been	be	VBN
cord-316996-8yimrpaz	264	10	developed	develop	VBN
cord-316996-8yimrpaz	264	11	over	over	IN
cord-316996-8yimrpaz	264	12	the	the	DT
cord-316996-8yimrpaz	264	13	past	past	JJ
cord-316996-8yimrpaz	264	14	six	six	CD
cord-316996-8yimrpaz	264	15	years	year	NNS
cord-316996-8yimrpaz	264	16	from	from	IN
cord-316996-8yimrpaz	264	17	in	in	IN
cord-316996-8yimrpaz	264	18	vitro	vitro	FW
cord-316996-8yimrpaz	264	19	testing	testing	NN
cord-316996-8yimrpaz	264	20	to	to	IN
cord-316996-8yimrpaz	264	21	Phase	Phase	NNP
cord-316996-8yimrpaz	264	22	II	II	NNP
cord-316996-8yimrpaz	264	23	studies	study	NNS
cord-316996-8yimrpaz	264	24	for	for	IN
cord-316996-8yimrpaz	264	25	influenza	influenza	NN
cord-316996-8yimrpaz	264	26	virus	virus	NN
cord-316996-8yimrpaz	264	27	infection	infection	NN
cord-316996-8yimrpaz	264	28	.	.	.
cord-316996-8yimrpaz	265	1	This	this	DT
cord-316996-8yimrpaz	265	2	agent	agent	NN
cord-316996-8yimrpaz	265	3	shows	show	VBZ
cord-316996-8yimrpaz	265	4	promise	promise	NN
cord-316996-8yimrpaz	265	5	in	in	IN
cord-316996-8yimrpaz	265	6	the	the	DT
cord-316996-8yimrpaz	265	7	repertoire	repertoire	NN
cord-316996-8yimrpaz	265	8	of	of	IN
cord-316996-8yimrpaz	265	9	antivirals	antiviral	NNS
cord-316996-8yimrpaz	265	10	for	for	IN
cord-316996-8yimrpaz	265	11	influenza	influenza	NN
cord-316996-8yimrpaz	265	12	,	,	,
cord-316996-8yimrpaz	265	13	and	and	CC
cord-316996-8yimrpaz	265	14	it	-PRON-	PRP
cord-316996-8yimrpaz	265	15	should	should	MD
cord-316996-8yimrpaz	265	16	also	also	RB
cord-316996-8yimrpaz	265	17	show	show	VB
cord-316996-8yimrpaz	265	18	potential	potential	JJ
cord-316996-8yimrpaz	265	19	benefit	benefit	NN
cord-316996-8yimrpaz	265	20	against	against	IN
cord-316996-8yimrpaz	265	21	other	other	JJ
cord-316996-8yimrpaz	265	22	respiratory	respiratory	JJ
cord-316996-8yimrpaz	265	23	viruses	virus	NNS
cord-316996-8yimrpaz	265	24	that	that	WDT
cord-316996-8yimrpaz	265	25	use	use	VBP
cord-316996-8yimrpaz	265	26	Sia	Sia	NNP
cord-316996-8yimrpaz	265	27	as	as	IN
cord-316996-8yimrpaz	265	28	a	a	DT
cord-316996-8yimrpaz	265	29	receptor	receptor	NN
cord-316996-8yimrpaz	265	30	,	,	,
cord-316996-8yimrpaz	265	31	such	such	JJ
cord-316996-8yimrpaz	265	32	as	as	IN
cord-316996-8yimrpaz	265	33	severe	severe	JJ
cord-316996-8yimrpaz	265	34	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	265	35	virus	virus	NN
cord-316996-8yimrpaz	265	36	infection	infection	NN
cord-316996-8yimrpaz	265	37	.	.	.
cord-316996-8yimrpaz	266	1	Red	red	JJ
cord-316996-8yimrpaz	266	2	cells	cell	NNS
cord-316996-8yimrpaz	266	3	bound	bind	VBN
cord-316996-8yimrpaz	266	4	to	to	IN
cord-316996-8yimrpaz	266	5	influenza	influenza	NN
cord-316996-8yimrpaz	266	6	virus	virus	NN
cord-316996-8yimrpaz	267	1	N9	N9	NNP
cord-316996-8yimrpaz	267	2	neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	267	3	are	be	VBP
cord-316996-8yimrpaz	267	4	not	not	RB
cord-316996-8yimrpaz	267	5	released	release	VBN
cord-316996-8yimrpaz	267	6	by	by	IN
cord-316996-8yimrpaz	267	7	the	the	DT
cord-316996-8yimrpaz	267	8	N9	N9	NNP
cord-316996-8yimrpaz	267	9	neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	267	10	activity	activity	NN
cord-316996-8yimrpaz	267	11	Docking	Docking	NNP
cord-316996-8yimrpaz	267	12	of	of	IN
cord-316996-8yimrpaz	267	13	sialic	sialic	JJ
cord-316996-8yimrpaz	267	14	acid	acid	NN
cord-316996-8yimrpaz	267	15	analogues	analogue	NNS
cord-316996-8yimrpaz	267	16	against	against	IN
cord-316996-8yimrpaz	267	17	influenza	influenza	NN
cord-316996-8yimrpaz	267	18	A	a	DT
cord-316996-8yimrpaz	267	19	hemagglutinin	hemagglutinin	NN
cord-316996-8yimrpaz	267	20	:	:	:
cord-316996-8yimrpaz	267	21	a	a	DT
cord-316996-8yimrpaz	267	22	correlational	correlational	JJ
cord-316996-8yimrpaz	267	23	study	study	NN
cord-316996-8yimrpaz	267	24	between	between	IN
cord-316996-8yimrpaz	267	25	experimentally	experimentally	RB
cord-316996-8yimrpaz	267	26	measured	measure	VBN
cord-316996-8yimrpaz	267	27	and	and	CC
cord-316996-8yimrpaz	267	28	computationally	computationally	RB
cord-316996-8yimrpaz	267	29	estimated	estimate	VBN
cord-316996-8yimrpaz	267	30	affinities	affinity	NNS
cord-316996-8yimrpaz	267	31	Site	site	NN
cord-316996-8yimrpaz	267	32	-	-	HYPH
cord-316996-8yimrpaz	267	33	directed	direct	VBN
cord-316996-8yimrpaz	267	34	fragment	fragment	NN
cord-316996-8yimrpaz	267	35	-	-	HYPH
cord-316996-8yimrpaz	267	36	based	base	VBN
cord-316996-8yimrpaz	267	37	generation	generation	NN
cord-316996-8yimrpaz	267	38	of	of	IN
cord-316996-8yimrpaz	267	39	virtual	virtual	JJ
cord-316996-8yimrpaz	267	40	sialic	sialic	NN
cord-316996-8yimrpaz	267	41	acid	acid	NN
cord-316996-8yimrpaz	267	42	databases	database	NNS
cord-316996-8yimrpaz	267	43	against	against	IN
cord-316996-8yimrpaz	267	44	influenza	influenza	NN
cord-316996-8yimrpaz	267	45	A	a	DT
cord-316996-8yimrpaz	267	46	hemagglutinin	hemagglutinin	NN
cord-316996-8yimrpaz	267	47	Characterization	characterization	NN
cord-316996-8yimrpaz	267	48	of	of	IN
cord-316996-8yimrpaz	267	49	a	a	DT
cord-316996-8yimrpaz	267	50	carbohydrate	carbohydrate	NN
cord-316996-8yimrpaz	267	51	epitope	epitope	NN
cord-316996-8yimrpaz	267	52	defined	define	VBN
cord-316996-8yimrpaz	267	53	by	by	IN
cord-316996-8yimrpaz	267	54	the	the	DT
cord-316996-8yimrpaz	267	55	monoclonal	monoclonal	JJ
cord-316996-8yimrpaz	267	56	antibody	antibody	NN
cord-316996-8yimrpaz	267	57	H185	h185	CD
cord-316996-8yimrpaz	267	58	:	:	:
cord-316996-8yimrpaz	267	59	sialic	sialic	NN
cord-316996-8yimrpaz	267	60	acid	acid	NN
cord-316996-8yimrpaz	267	61	O	o	NN
cord-316996-8yimrpaz	267	62	-	-	HYPH
cord-316996-8yimrpaz	267	63	acetylation	acetylation	NN
cord-316996-8yimrpaz	267	64	on	on	IN
cord-316996-8yimrpaz	267	65	epithelial	epithelial	JJ
cord-316996-8yimrpaz	267	66	cell	cell	NN
cord-316996-8yimrpaz	267	67	-	-	HYPH
cord-316996-8yimrpaz	267	68	surface	surface	NN
cord-316996-8yimrpaz	267	69	mucins	mucin	NNS
cord-316996-8yimrpaz	268	1	The	the	DT
cord-316996-8yimrpaz	268	2	human	human	JJ
cord-316996-8yimrpaz	268	3	Cas1	Cas1	NNP
cord-316996-8yimrpaz	268	4	protein	protein	NN
cord-316996-8yimrpaz	268	5	:	:	:
cord-316996-8yimrpaz	268	6	a	a	DT
cord-316996-8yimrpaz	268	7	sialic	sialic	JJ
cord-316996-8yimrpaz	268	8	acid	acid	NN
cord-316996-8yimrpaz	268	9	-	-	HYPH
cord-316996-8yimrpaz	268	10	specific	specific	JJ
cord-316996-8yimrpaz	268	11	Oacetyltransferase	Oacetyltransferase	NNP
cord-316996-8yimrpaz	268	12	?	?	.
cord-316996-8yimrpaz	269	1	The	the	DT
cord-316996-8yimrpaz	269	2	effect	effect	NN
cord-316996-8yimrpaz	269	3	of	of	IN
cord-316996-8yimrpaz	269	4	glycosylation	glycosylation	NN
cord-316996-8yimrpaz	269	5	on	on	IN
cord-316996-8yimrpaz	269	6	the	the	DT
cord-316996-8yimrpaz	269	7	folding	fold	VBG
cord-316996-8yimrpaz	269	8	kinetics	kinetic	NNS
cord-316996-8yimrpaz	269	9	of	of	IN
cord-316996-8yimrpaz	269	10	erythropoietin	erythropoietin	NN
cord-316996-8yimrpaz	269	11	Role	role	NN
cord-316996-8yimrpaz	269	12	of	of	IN
cord-316996-8yimrpaz	269	13	gangliosides	ganglioside	NNS
cord-316996-8yimrpaz	269	14	in	in	IN
cord-316996-8yimrpaz	269	15	reception	reception	NN
cord-316996-8yimrpaz	269	16	of	of	IN
cord-316996-8yimrpaz	269	17	influenza	influenza	NN
cord-316996-8yimrpaz	269	18	virus	virus	NN
cord-316996-8yimrpaz	269	19	Senescent	Senescent	NNP
cord-316996-8yimrpaz	269	20	erythrocytes	erythrocyte	NNS
cord-316996-8yimrpaz	269	21	:	:	:
cord-316996-8yimrpaz	269	22	factors	factor	NNS
cord-316996-8yimrpaz	269	23	affecting	affect	VBG
cord-316996-8yimrpaz	269	24	the	the	DT
cord-316996-8yimrpaz	269	25	aging	aging	NN
cord-316996-8yimrpaz	269	26	of	of	IN
cord-316996-8yimrpaz	269	27	red	red	JJ
cord-316996-8yimrpaz	269	28	blood	blood	NN
cord-316996-8yimrpaz	269	29	cells	cell	NNS
cord-316996-8yimrpaz	269	30	Molecular	molecular	JJ
cord-316996-8yimrpaz	269	31	dynamics	dynamic	NNS
cord-316996-8yimrpaz	269	32	of	of	IN
cord-316996-8yimrpaz	269	33	sialic	sialic	JJ
cord-316996-8yimrpaz	269	34	acid	acid	JJ
cord-316996-8yimrpaz	269	35	analogues	analogue	NNS
cord-316996-8yimrpaz	269	36	and	and	CC
cord-316996-8yimrpaz	269	37	their	-PRON-	PRP$
cord-316996-8yimrpaz	269	38	interaction	interaction	NN
cord-316996-8yimrpaz	269	39	with	with	IN
cord-316996-8yimrpaz	269	40	influenza	influenza	NN
cord-316996-8yimrpaz	269	41	hemagglutinin	hemagglutinin	VBN
cord-316996-8yimrpaz	269	42	Human	human	JJ
cord-316996-8yimrpaz	269	43	rhinovirus	rhinovirus	NN
cord-316996-8yimrpaz	269	44	87	87	CD
cord-316996-8yimrpaz	269	45	and	and	CC
cord-316996-8yimrpaz	269	46	enterovirus	enterovirus	NN
cord-316996-8yimrpaz	269	47	68	68	CD
cord-316996-8yimrpaz	269	48	represent	represent	VBP
cord-316996-8yimrpaz	269	49	a	a	DT
cord-316996-8yimrpaz	269	50	unique	unique	JJ
cord-316996-8yimrpaz	269	51	serotype	serotype	NN
cord-316996-8yimrpaz	269	52	with	with	IN
cord-316996-8yimrpaz	269	53	rhinovirus	rhinovirus	NN
cord-316996-8yimrpaz	269	54	and	and	CC
cord-316996-8yimrpaz	269	55	enterovirus	enterovirus	NN
cord-316996-8yimrpaz	269	56	features	feature	VBZ
cord-316996-8yimrpaz	269	57	Cellular	cellular	JJ
cord-316996-8yimrpaz	269	58	and	and	CC
cord-316996-8yimrpaz	269	59	molecular	molecular	JJ
cord-316996-8yimrpaz	269	60	mechanisms	mechanism	NNS
cord-316996-8yimrpaz	269	61	of	of	IN
cord-316996-8yimrpaz	269	62	senescent	senescent	JJ
cord-316996-8yimrpaz	269	63	erythrocyte	erythrocyte	NN
cord-316996-8yimrpaz	269	64	phagocytosis	phagocytosis	NN
cord-316996-8yimrpaz	269	65	by	by	IN
cord-316996-8yimrpaz	269	66	macrophages	macrophage	NNS
cord-316996-8yimrpaz	269	67	.	.	.
cord-316996-8yimrpaz	270	1	A	a	DT
cord-316996-8yimrpaz	270	2	review	review	NN
cord-316996-8yimrpaz	270	3	Deaths	death	NNS
cord-316996-8yimrpaz	270	4	from	from	IN
cord-316996-8yimrpaz	270	5	bacterial	bacterial	JJ
cord-316996-8yimrpaz	270	6	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	270	7	during	during	IN
cord-316996-8yimrpaz	270	8	1918	1918	CD
cord-316996-8yimrpaz	270	9	-	-	SYM
cord-316996-8yimrpaz	270	10	19	19	CD
cord-316996-8yimrpaz	270	11	influenza	influenza	NN
cord-316996-8yimrpaz	270	12	pandemic	pandemic	NN
cord-316996-8yimrpaz	270	13	Diversity	diversity	NN
cord-316996-8yimrpaz	270	14	of	of	IN
cord-316996-8yimrpaz	270	15	the	the	DT
cord-316996-8yimrpaz	270	16	human	human	JJ
cord-316996-8yimrpaz	270	17	erythrocyte	erythrocyte	NN
cord-316996-8yimrpaz	270	18	membrane	membrane	NN
cord-316996-8yimrpaz	270	19	sialic	sialic	NN
cord-316996-8yimrpaz	270	20	acids	acid	NNS
cord-316996-8yimrpaz	270	21	in	in	IN
cord-316996-8yimrpaz	270	22	relation	relation	NN
cord-316996-8yimrpaz	270	23	with	with	IN
cord-316996-8yimrpaz	270	24	blood	blood	NN
cord-316996-8yimrpaz	270	25	groups	group	NNS
cord-316996-8yimrpaz	271	1	The	the	DT
cord-316996-8yimrpaz	271	2	multiple	multiple	JJ
cord-316996-8yimrpaz	271	3	roles	role	NNS
cord-316996-8yimrpaz	271	4	of	of	IN
cord-316996-8yimrpaz	271	5	amphiregulin	amphiregulin	NNP
cord-316996-8yimrpaz	271	6	in	in	IN
cord-316996-8yimrpaz	271	7	human	human	JJ
cord-316996-8yimrpaz	271	8	cancer	cancer	NN
cord-316996-8yimrpaz	271	9	Sialidase	Sialidase	NNP
cord-316996-8yimrpaz	271	10	substrate	substrate	NN
cord-316996-8yimrpaz	271	11	specificity	specificity	NN
cord-316996-8yimrpaz	271	12	studies	study	NNS
cord-316996-8yimrpaz	271	13	using	use	VBG
cord-316996-8yimrpaz	271	14	chemoenzymatically	chemoenzymatically	RB
cord-316996-8yimrpaz	271	15	synthesized	synthesize	VBN
cord-316996-8yimrpaz	271	16	sialosides	sialoside	NNS
cord-316996-8yimrpaz	271	17	containing	contain	VBG
cord-316996-8yimrpaz	271	18	C5-modified	c5-modifie	VBN
cord-316996-8yimrpaz	272	1	sialic	sialic	JJ
cord-316996-8yimrpaz	272	2	acids	acid	NNS
cord-316996-8yimrpaz	272	3	DAS181	DAS181	NNP
cord-316996-8yimrpaz	272	4	inhibits	inhibit	VBZ
cord-316996-8yimrpaz	272	5	H5N1	H5N1	NNP
cord-316996-8yimrpaz	272	6	influenza	influenza	NN
cord-316996-8yimrpaz	272	7	virus	virus	NN
cord-316996-8yimrpaz	272	8	infection	infection	NN
cord-316996-8yimrpaz	272	9	of	of	IN
cord-316996-8yimrpaz	272	10	human	human	JJ
cord-316996-8yimrpaz	272	11	lung	lung	NN
cord-316996-8yimrpaz	272	12	tissues	tissue	VBZ
cord-316996-8yimrpaz	272	13	Advances	advance	NNS
cord-316996-8yimrpaz	272	14	in	in	IN
cord-316996-8yimrpaz	272	15	the	the	DT
cord-316996-8yimrpaz	272	16	biology	biology	NN
cord-316996-8yimrpaz	272	17	and	and	CC
cord-316996-8yimrpaz	272	18	chemistry	chemistry	NN
cord-316996-8yimrpaz	272	19	of	of	IN
cord-316996-8yimrpaz	272	20	sialic	sialic	JJ
cord-316996-8yimrpaz	272	21	acids	acid	NNS
cord-316996-8yimrpaz	272	22	Treatment	Treatment	NNP
cord-316996-8yimrpaz	272	23	of	of	IN
cord-316996-8yimrpaz	272	24	parainfluenza	parainfluenza	NN
cord-316996-8yimrpaz	272	25	3	3	CD
cord-316996-8yimrpaz	272	26	infection	infection	NN
cord-316996-8yimrpaz	272	27	with	with	IN
cord-316996-8yimrpaz	272	28	DAS181	DAS181	NNP
cord-316996-8yimrpaz	272	29	in	in	IN
cord-316996-8yimrpaz	272	30	a	a	DT
cord-316996-8yimrpaz	272	31	patient	patient	NN
cord-316996-8yimrpaz	272	32	after	after	IN
cord-316996-8yimrpaz	272	33	allogeneic	allogeneic	NN
cord-316996-8yimrpaz	272	34	stem	stem	NN
cord-316996-8yimrpaz	272	35	cell	cell	NN
cord-316996-8yimrpaz	272	36	transplantation	transplantation	NN
cord-316996-8yimrpaz	273	1	The	the	DT
cord-316996-8yimrpaz	273	2	release	release	NN
cord-316996-8yimrpaz	273	3	of	of	IN
cord-316996-8yimrpaz	273	4	N	n	NN
cord-316996-8yimrpaz	273	5	-	-	HYPH
cord-316996-8yimrpaz	273	6	acetyl	acetyl	NNP
cord-316996-8yimrpaz	273	7	-	-	:
cord-316996-8yimrpaz	273	8	and	and	CC
cord-316996-8yimrpaz	273	9	N	N	NNP
cord-316996-8yimrpaz	273	10	-	-	HYPH
cord-316996-8yimrpaz	273	11	glycolloyl	glycolloyl	NNP
cord-316996-8yimrpaz	273	12	-	-	HYPH
cord-316996-8yimrpaz	273	13	neuraminic	neuraminic	JJ
cord-316996-8yimrpaz	273	14	acid	acid	NN
cord-316996-8yimrpaz	273	15	from	from	IN
cord-316996-8yimrpaz	273	16	soluble	soluble	JJ
cord-316996-8yimrpaz	273	17	complex	complex	JJ
cord-316996-8yimrpaz	273	18	carbohydrates	carbohydrate	NNS
cord-316996-8yimrpaz	273	19	and	and	CC
cord-316996-8yimrpaz	273	20	erythrocytes	erythrocyte	NNS
cord-316996-8yimrpaz	273	21	by	by	IN
cord-316996-8yimrpaz	273	22	bacterial	bacterial	JJ
cord-316996-8yimrpaz	273	23	,	,	,
cord-316996-8yimrpaz	273	24	viral	viral	JJ
cord-316996-8yimrpaz	273	25	and	and	CC
cord-316996-8yimrpaz	273	26	mammalian	mammalian	JJ
cord-316996-8yimrpaz	273	27	sialidases	sialidase	NNS
cord-316996-8yimrpaz	274	1	The	the	DT
cord-316996-8yimrpaz	274	2	specificity	specificity	NN
cord-316996-8yimrpaz	274	3	of	of	IN
cord-316996-8yimrpaz	274	4	viral	viral	JJ
cord-316996-8yimrpaz	274	5	and	and	CC
cord-316996-8yimrpaz	274	6	bacterial	bacterial	JJ
cord-316996-8yimrpaz	274	7	sialidases	sialidase	NNS
cord-316996-8yimrpaz	274	8	for	for	IN
cord-316996-8yimrpaz	274	9	alpha(2	alpha(2	NNP
cord-316996-8yimrpaz	274	10	-	-	HYPH
cord-316996-8yimrpaz	274	11	3)-and	3)-and	NNP
cord-316996-8yimrpaz	274	12	alpha(2	alpha(2	NNP
cord-316996-8yimrpaz	274	13	-	-	HYPH
cord-316996-8yimrpaz	274	14	6)-linked	6)-linked	CD
cord-316996-8yimrpaz	274	15	sialic	sialic	JJ
cord-316996-8yimrpaz	274	16	acids	acid	NNS
cord-316996-8yimrpaz	274	17	in	in	IN
cord-316996-8yimrpaz	274	18	glycoproteins	glycoprotein	NNS
cord-316996-8yimrpaz	274	19	Metabolism	metabolism	NN
cord-316996-8yimrpaz	274	20	of	of	IN
cord-316996-8yimrpaz	274	21	vertebrate	vertebrate	JJ
cord-316996-8yimrpaz	274	22	amino	amino	NN
cord-316996-8yimrpaz	274	23	sugars	sugar	NNS
cord-316996-8yimrpaz	274	24	with	with	IN
cord-316996-8yimrpaz	274	25	N	n	CD
cord-316996-8yimrpaz	274	26	-	-	HYPH
cord-316996-8yimrpaz	274	27	glycolyl	glycolyl	NNP
cord-316996-8yimrpaz	274	28	groups	group	NNS
cord-316996-8yimrpaz	274	29	:	:	:
cord-316996-8yimrpaz	274	30	resistance	resistance	NN
cord-316996-8yimrpaz	274	31	of	of	IN
cord-316996-8yimrpaz	274	32	alpha2	alpha2	NN
cord-316996-8yimrpaz	274	33	-	-	HYPH
cord-316996-8yimrpaz	274	34	8-linked	8-linked	CD
cord-316996-8yimrpaz	274	35	N	n	CD
cord-316996-8yimrpaz	274	36	-	-	HYPH
cord-316996-8yimrpaz	274	37	glycolylneuraminic	glycolylneuraminic	NN
cord-316996-8yimrpaz	274	38	acid	acid	NN
cord-316996-8yimrpaz	274	39	to	to	IN
cord-316996-8yimrpaz	274	40	enzymatic	enzymatic	JJ
cord-316996-8yimrpaz	274	41	cleavage	cleavage	NN
cord-316996-8yimrpaz	275	1	DAS181	das181	JJ
cord-316996-8yimrpaz	275	2	treatment	treatment	NN
cord-316996-8yimrpaz	275	3	of	of	IN
cord-316996-8yimrpaz	275	4	severe	severe	JJ
cord-316996-8yimrpaz	275	5	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	275	6	type	type	NN
cord-316996-8yimrpaz	275	7	3	3	CD
cord-316996-8yimrpaz	275	8	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	275	9	in	in	IN
cord-316996-8yimrpaz	275	10	a	a	DT
cord-316996-8yimrpaz	275	11	lung	lung	NN
cord-316996-8yimrpaz	275	12	transplant	transplant	NN
cord-316996-8yimrpaz	275	13	recipient	recipient	NN
cord-316996-8yimrpaz	275	14	On	on	IN
cord-316996-8yimrpaz	275	15	the	the	DT
cord-316996-8yimrpaz	275	16	relationship	relationship	NN
cord-316996-8yimrpaz	275	17	between	between	IN
cord-316996-8yimrpaz	275	18	the	the	DT
cord-316996-8yimrpaz	275	19	indicator	indicator	NN
cord-316996-8yimrpaz	275	20	profile	profile	NN
cord-316996-8yimrpaz	275	21	and	and	CC
cord-316996-8yimrpaz	275	22	prosthetic	prosthetic	JJ
cord-316996-8yimrpaz	275	23	group	group	NN
cord-316996-8yimrpaz	275	24	of	of	IN
cord-316996-8yimrpaz	275	25	mucoproteins	mucoproteins	NNP
cord-316996-8yimrpaz	275	26	inhibitory	inhibitory	JJ
cord-316996-8yimrpaz	275	27	for	for	IN
cord-316996-8yimrpaz	276	1	influenza	influenza	NNP
cord-316996-8yimrpaz	276	2	virus	virus	NNP
cord-316996-8yimrpaz	276	3	haemagglutinin	haemagglutinin	NNP
cord-316996-8yimrpaz	277	1	The	the	DT
cord-316996-8yimrpaz	277	2	Ashwell	Ashwell	NNP
cord-316996-8yimrpaz	277	3	receptor	receptor	NN
cord-316996-8yimrpaz	277	4	mitigates	mitigate	VBZ
cord-316996-8yimrpaz	277	5	the	the	DT
cord-316996-8yimrpaz	277	6	lethal	lethal	JJ
cord-316996-8yimrpaz	277	7	coagulopathy	coagulopathy	NN
cord-316996-8yimrpaz	277	8	of	of	IN
cord-316996-8yimrpaz	277	9	sepsis	sepsis	NN
cord-316996-8yimrpaz	277	10	Effects	effect	NNS
cord-316996-8yimrpaz	277	11	of	of	IN
cord-316996-8yimrpaz	277	12	hexose	hexose	JJS
cord-316996-8yimrpaz	277	13	starvation	starvation	NN
cord-316996-8yimrpaz	277	14	and	and	CC
cord-316996-8yimrpaz	277	15	the	the	DT
cord-316996-8yimrpaz	277	16	role	role	NN
cord-316996-8yimrpaz	277	17	of	of	IN
cord-316996-8yimrpaz	277	18	sialic	sialic	JJ
cord-316996-8yimrpaz	277	19	acid	acid	NN
cord-316996-8yimrpaz	277	20	in	in	IN
cord-316996-8yimrpaz	277	21	influenza	influenza	NN
cord-316996-8yimrpaz	277	22	virus	virus	NN
cord-316996-8yimrpaz	277	23	release	release	NN
cord-316996-8yimrpaz	277	24	Unveiling	unveil	VBG
cord-316996-8yimrpaz	277	25	the	the	DT
cord-316996-8yimrpaz	277	26	burden	burden	NN
cord-316996-8yimrpaz	277	27	of	of	IN
cord-316996-8yimrpaz	277	28	influenza	influenza	NN
cord-316996-8yimrpaz	277	29	-	-	HYPH
cord-316996-8yimrpaz	277	30	associated	associate	VBN
cord-316996-8yimrpaz	277	31	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	277	32	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	277	33	Structural	structural	JJ
cord-316996-8yimrpaz	277	34	and	and	CC
cord-316996-8yimrpaz	277	35	functional	functional	JJ
cord-316996-8yimrpaz	277	36	studies	study	NNS
cord-316996-8yimrpaz	277	37	of	of	IN
cord-316996-8yimrpaz	277	38	Streptococcus	Streptococcus	NNP
cord-316996-8yimrpaz	277	39	pneumoniae	pneumoniae	NN
cord-316996-8yimrpaz	277	40	neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	277	41	B	b	NN
cord-316996-8yimrpaz	277	42	:	:	:
cord-316996-8yimrpaz	277	43	an	an	DT
cord-316996-8yimrpaz	277	44	intramolecular	intramolecular	JJ
cord-316996-8yimrpaz	277	45	trans	trans	NNP
cord-316996-8yimrpaz	277	46	-	-	JJ
cord-316996-8yimrpaz	277	47	sialidase	sialidase	NNP
cord-316996-8yimrpaz	277	48	Clinical	clinical	JJ
cord-316996-8yimrpaz	277	49	potential	potential	NN
cord-316996-8yimrpaz	277	50	of	of	IN
cord-316996-8yimrpaz	277	51	DAS181	DAS181	NNP
cord-316996-8yimrpaz	277	52	for	for	IN
cord-316996-8yimrpaz	277	53	treatment	treatment	NN
cord-316996-8yimrpaz	277	54	of	of	IN
cord-316996-8yimrpaz	277	55	parainfluenza-3	parainfluenza-3	NNP
cord-316996-8yimrpaz	277	56	infections	infection	NNS
cord-316996-8yimrpaz	277	57	in	in	IN
cord-316996-8yimrpaz	277	58	transplant	transplant	NN
cord-316996-8yimrpaz	277	59	recipients	recipient	NNS
cord-316996-8yimrpaz	277	60	Clinical	clinical	JJ
cord-316996-8yimrpaz	277	61	and	and	CC
cord-316996-8yimrpaz	277	62	microbiological	microbiological	JJ
cord-316996-8yimrpaz	277	63	features	feature	NNS
cord-316996-8yimrpaz	277	64	of	of	IN
cord-316996-8yimrpaz	277	65	subjects	subject	NNS
cord-316996-8yimrpaz	277	66	with	with	IN
cord-316996-8yimrpaz	277	67	adult	adult	NN
cord-316996-8yimrpaz	277	68	periodontitis	periodontitis	NN
cord-316996-8yimrpaz	277	69	who	who	WP
cord-316996-8yimrpaz	277	70	responded	respond	VBD
cord-316996-8yimrpaz	277	71	poorly	poorly	RB
cord-316996-8yimrpaz	277	72	to	to	IN
cord-316996-8yimrpaz	277	73	scaling	scale	VBG
cord-316996-8yimrpaz	277	74	and	and	CC
cord-316996-8yimrpaz	277	75	root	root	NN
cord-316996-8yimrpaz	277	76	planing	plane	VBG
cord-316996-8yimrpaz	277	77	4-O	4-o	CD
cord-316996-8yimrpaz	277	78	-	-	HYPH
cord-316996-8yimrpaz	277	79	acetyl	acetyl	NN
cord-316996-8yimrpaz	277	80	-	-	HYPH
cord-316996-8yimrpaz	277	81	N	N	NNP
cord-316996-8yimrpaz	277	82	-	-	HYPH
cord-316996-8yimrpaz	277	83	acetylneuraminic	acetylneuraminic	NNP
cord-316996-8yimrpaz	277	84	acid	acid	NN
cord-316996-8yimrpaz	277	85	in	in	IN
cord-316996-8yimrpaz	277	86	the	the	DT
cord-316996-8yimrpaz	277	87	N	n	NN
cord-316996-8yimrpaz	277	88	-	-	HYPH
cord-316996-8yimrpaz	277	89	linked	link	VBN
cord-316996-8yimrpaz	277	90	carbohydrate	carbohydrate	NN
cord-316996-8yimrpaz	277	91	structures	structure	NNS
cord-316996-8yimrpaz	277	92	of	of	IN
cord-316996-8yimrpaz	277	93	equine	equine	NN
cord-316996-8yimrpaz	277	94	and	and	CC
cord-316996-8yimrpaz	277	95	guinea	guinea	NN
cord-316996-8yimrpaz	277	96	pig	pig	NN
cord-316996-8yimrpaz	277	97	alpha	alpha	NNP
cord-316996-8yimrpaz	277	98	2-macroglobulins	2-macroglobulins	NNP
cord-316996-8yimrpaz	277	99	,	,	,
cord-316996-8yimrpaz	277	100	potent	potent	JJ
cord-316996-8yimrpaz	277	101	inhibitors	inhibitor	NNS
cord-316996-8yimrpaz	277	102	of	of	IN
cord-316996-8yimrpaz	277	103	influenza	influenza	NN
cord-316996-8yimrpaz	277	104	virus	virus	NN
cord-316996-8yimrpaz	277	105	infection	infection	NN
cord-316996-8yimrpaz	278	1	The	the	DT
cord-316996-8yimrpaz	278	2	animal	animal	NN
cord-316996-8yimrpaz	278	3	sialyltransferases	sialyltransferase	NNS
cord-316996-8yimrpaz	278	4	and	and	CC
cord-316996-8yimrpaz	278	5	sialyltransferase	sialyltransferase	NNP
cord-316996-8yimrpaz	278	6	-	-	HYPH
cord-316996-8yimrpaz	278	7	related	relate	VBN
cord-316996-8yimrpaz	278	8	genes	gene	NNS
cord-316996-8yimrpaz	278	9	:	:	:
cord-316996-8yimrpaz	278	10	a	a	DT
cord-316996-8yimrpaz	278	11	phylogenetic	phylogenetic	JJ
cord-316996-8yimrpaz	278	12	approach	approach	NN
cord-316996-8yimrpaz	279	1	Sialidasebased	sialidasebased	JJ
cord-316996-8yimrpaz	279	2	anti	anti	JJ
cord-316996-8yimrpaz	279	3	-	-	JJ
cord-316996-8yimrpaz	279	4	influenza	influenza	JJ
cord-316996-8yimrpaz	279	5	virus	virus	NN
cord-316996-8yimrpaz	279	6	therapy	therapy	NN
cord-316996-8yimrpaz	279	7	protects	protect	VBZ
cord-316996-8yimrpaz	279	8	against	against	IN
cord-316996-8yimrpaz	279	9	secondary	secondary	JJ
cord-316996-8yimrpaz	279	10	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	279	11	infection	infection	NN
cord-316996-8yimrpaz	280	1	The	the	DT
cord-316996-8yimrpaz	280	2	viral	viral	JJ
cord-316996-8yimrpaz	280	3	sigma1	sigma1	NN
cord-316996-8yimrpaz	280	4	protein	protein	NN
cord-316996-8yimrpaz	280	5	and	and	CC
cord-316996-8yimrpaz	280	6	glycoconjugates	glycoconjugates	NNPS
cord-316996-8yimrpaz	280	7	containing	contain	VBG
cord-316996-8yimrpaz	280	8	alpha2	alpha2	NN
cord-316996-8yimrpaz	280	9	-	-	HYPH
cord-316996-8yimrpaz	280	10	3-linked	3-linked	CD
cord-316996-8yimrpaz	280	11	sialic	sialic	JJ
cord-316996-8yimrpaz	280	12	acid	acid	NN
cord-316996-8yimrpaz	280	13	are	be	VBP
cord-316996-8yimrpaz	280	14	involved	involve	VBN
cord-316996-8yimrpaz	280	15	in	in	IN
cord-316996-8yimrpaz	280	16	type	type	NN
cord-316996-8yimrpaz	280	17	1	1	CD
cord-316996-8yimrpaz	280	18	reovirus	reovirus	NN
cord-316996-8yimrpaz	280	19	adherence	adherence	NN
cord-316996-8yimrpaz	280	20	to	to	IN
cord-316996-8yimrpaz	280	21	M	M	NNP
cord-316996-8yimrpaz	280	22	cell	cell	NN
cord-316996-8yimrpaz	280	23	apical	apical	JJ
cord-316996-8yimrpaz	280	24	surfaces	surface	NNS
cord-316996-8yimrpaz	280	25	Airborne	airborne	JJ
cord-316996-8yimrpaz	280	26	transmission	transmission	NN
cord-316996-8yimrpaz	280	27	of	of	IN
cord-316996-8yimrpaz	280	28	influenza	influenza	NN
cord-316996-8yimrpaz	280	29	A/	A/	NNP
cord-316996-8yimrpaz	280	30	H5N1	H5N1	NNP
cord-316996-8yimrpaz	280	31	virus	virus	NN
cord-316996-8yimrpaz	280	32	between	between	IN
cord-316996-8yimrpaz	280	33	ferrets	ferret	NNS
cord-316996-8yimrpaz	280	34	Polysialylation	Polysialylation	NNP
cord-316996-8yimrpaz	280	35	of	of	IN
cord-316996-8yimrpaz	280	36	NCAM	NCAM	NNP
cord-316996-8yimrpaz	280	37	Experimental	experimental	JJ
cord-316996-8yimrpaz	280	38	adaptation	adaptation	NN
cord-316996-8yimrpaz	280	39	of	of	IN
cord-316996-8yimrpaz	280	40	an	an	DT
cord-316996-8yimrpaz	280	41	influenza	influenza	NN
cord-316996-8yimrpaz	281	1	H5	H5	NNP
cord-316996-8yimrpaz	281	2	HA	HA	NNP
cord-316996-8yimrpaz	281	3	confers	confer	VBZ
cord-316996-8yimrpaz	281	4	respiratory	respiratory	JJ
cord-316996-8yimrpaz	281	5	droplet	droplet	NN
cord-316996-8yimrpaz	281	6	transmission	transmission	NN
cord-316996-8yimrpaz	281	7	to	to	IN
cord-316996-8yimrpaz	281	8	a	a	DT
cord-316996-8yimrpaz	281	9	reassortant	reassortant	JJ
cord-316996-8yimrpaz	281	10	H5	H5	NNP
cord-316996-8yimrpaz	281	11	HA	HA	NNP
cord-316996-8yimrpaz	281	12	/	/	SYM
cord-316996-8yimrpaz	281	13	H1N1	H1N1	NNP
cord-316996-8yimrpaz	281	14	virus	virus	NN
cord-316996-8yimrpaz	281	15	in	in	IN
cord-316996-8yimrpaz	281	16	ferrets	ferret	NNS
cord-316996-8yimrpaz	281	17	Influenza	Influenza	NNP
cord-316996-8yimrpaz	281	18	virus	virus	NN
cord-316996-8yimrpaz	281	19	primes	prime	VBZ
cord-316996-8yimrpaz	281	20	mice	mouse	NNS
cord-316996-8yimrpaz	281	21	for	for	IN
cord-316996-8yimrpaz	281	22	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	281	23	from	from	IN
cord-316996-8yimrpaz	281	24	Staphylococcus	Staphylococcus	NNP
cord-316996-8yimrpaz	281	25	aureus	aureus	NN
cord-316996-8yimrpaz	282	1	Toll	toll	NN
cord-316996-8yimrpaz	282	2	-	-	HYPH
cord-316996-8yimrpaz	282	3	like	like	JJ
cord-316996-8yimrpaz	282	4	receptor	receptor	NN
cord-316996-8yimrpaz	282	5	2	2	CD
cord-316996-8yimrpaz	282	6	mediates	mediate	VBZ
cord-316996-8yimrpaz	282	7	fatal	fatal	JJ
cord-316996-8yimrpaz	282	8	immunopathology	immunopathology	NN
cord-316996-8yimrpaz	282	9	in	in	IN
cord-316996-8yimrpaz	282	10	mice	mouse	NNS
cord-316996-8yimrpaz	282	11	during	during	IN
cord-316996-8yimrpaz	282	12	treatment	treatment	NN
cord-316996-8yimrpaz	282	13	of	of	IN
cord-316996-8yimrpaz	282	14	secondary	secondary	JJ
cord-316996-8yimrpaz	282	15	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	282	16	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	282	17	following	follow	VBG
cord-316996-8yimrpaz	282	18	influenza	influenza	NN
cord-316996-8yimrpaz	282	19	Features	feature	NNS
cord-316996-8yimrpaz	282	20	and	and	CC
cord-316996-8yimrpaz	282	21	applications	application	NNS
cord-316996-8yimrpaz	282	22	of	of	IN
cord-316996-8yimrpaz	282	23	bacterial	bacterial	JJ
cord-316996-8yimrpaz	282	24	sialidases	sialidase	NNS
cord-316996-8yimrpaz	282	25	O	o	NN
cord-316996-8yimrpaz	282	26	-	-	HYPH
cord-316996-8yimrpaz	282	27	acetylation	acetylation	NN
cord-316996-8yimrpaz	282	28	of	of	IN
cord-316996-8yimrpaz	282	29	sialic	sialic	JJ
cord-316996-8yimrpaz	282	30	acids	acid	NNS
cord-316996-8yimrpaz	282	31	A	a	DT
cord-316996-8yimrpaz	282	32	safety	safety	NN
cord-316996-8yimrpaz	282	33	evaluation	evaluation	NN
cord-316996-8yimrpaz	282	34	of	of	IN
cord-316996-8yimrpaz	282	35	DAS181	DAS181	NNP
cord-316996-8yimrpaz	282	36	,	,	,
cord-316996-8yimrpaz	282	37	a	a	DT
cord-316996-8yimrpaz	282	38	sialidase	sialidase	NN
cord-316996-8yimrpaz	282	39	fusion	fusion	NN
cord-316996-8yimrpaz	282	40	protein	protein	NN
cord-316996-8yimrpaz	282	41	,	,	,
cord-316996-8yimrpaz	282	42	in	in	IN
cord-316996-8yimrpaz	282	43	rodents	rodent	NNS
cord-316996-8yimrpaz	282	44	Sialic	Sialic	NNP
cord-316996-8yimrpaz	282	45	acid	acid	NN
cord-316996-8yimrpaz	282	46	-	-	HYPH
cord-316996-8yimrpaz	282	47	specific	specific	JJ
cord-316996-8yimrpaz	282	48	lectins	lectin	NNS
cord-316996-8yimrpaz	282	49	:	:	:
cord-316996-8yimrpaz	282	50	occurrence	occurrence	NN
cord-316996-8yimrpaz	282	51	,	,	,
cord-316996-8yimrpaz	282	52	specificity	specificity	NN
cord-316996-8yimrpaz	282	53	and	and	CC
cord-316996-8yimrpaz	282	54	function	function	NN
cord-316996-8yimrpaz	282	55	Binding	Binding	NNP
cord-316996-8yimrpaz	282	56	of	of	IN
cord-316996-8yimrpaz	282	57	viral	viral	JJ
cord-316996-8yimrpaz	282	58	attachment	attachment	NN
cord-316996-8yimrpaz	282	59	protein	protein	NN
cord-316996-8yimrpaz	282	60	to	to	IN
cord-316996-8yimrpaz	282	61	host	host	NN
cord-316996-8yimrpaz	282	62	-	-	HYPH
cord-316996-8yimrpaz	282	63	cell	cell	NN
cord-316996-8yimrpaz	282	64	receptor	receptor	NN
cord-316996-8yimrpaz	282	65	:	:	:
cord-316996-8yimrpaz	282	66	the	the	DT
cord-316996-8yimrpaz	282	67	Achilles	Achilles	NNP
cord-316996-8yimrpaz	282	68	heel	heel	NN
cord-316996-8yimrpaz	282	69	of	of	IN
cord-316996-8yimrpaz	282	70	infectious	infectious	JJ
cord-316996-8yimrpaz	282	71	viruses	virus	NNS
cord-316996-8yimrpaz	283	1	The	the	DT
cord-316996-8yimrpaz	283	2	recognition	recognition	NN
cord-316996-8yimrpaz	283	3	event	event	NN
cord-316996-8yimrpaz	283	4	between	between	IN
cord-316996-8yimrpaz	283	5	virus	virus	NN
cord-316996-8yimrpaz	283	6	and	and	CC
cord-316996-8yimrpaz	283	7	host	host	NN
cord-316996-8yimrpaz	283	8	cell	cell	NN
cord-316996-8yimrpaz	283	9	receptor	receptor	NN
cord-316996-8yimrpaz	283	10	:	:	:
cord-316996-8yimrpaz	283	11	a	a	DT
cord-316996-8yimrpaz	283	12	target	target	NN
cord-316996-8yimrpaz	283	13	for	for	IN
cord-316996-8yimrpaz	283	14	antiviral	antiviral	JJ
cord-316996-8yimrpaz	283	15	agents	agent	NNS
cord-316996-8yimrpaz	283	16	Novel	Novel	NNP
cord-316996-8yimrpaz	283	17	inhibitor	inhibitor	NN
cord-316996-8yimrpaz	283	18	design	design	NN
cord-316996-8yimrpaz	283	19	for	for	IN
cord-316996-8yimrpaz	283	20	hemagglutinin	hemagglutinin	NN
cord-316996-8yimrpaz	283	21	against	against	IN
cord-316996-8yimrpaz	283	22	H1N1	H1N1	NNP
cord-316996-8yimrpaz	283	23	influenza	influenza	NN
cord-316996-8yimrpaz	283	24	virus	virus	NN
cord-316996-8yimrpaz	283	25	by	by	IN
cord-316996-8yimrpaz	283	26	core	core	NN
cord-316996-8yimrpaz	283	27	hopping	hopping	NN
cord-316996-8yimrpaz	283	28	method	method	NN
cord-316996-8yimrpaz	283	29	Limit	limit	NN
cord-316996-8yimrpaz	283	30	dilution	dilution	NN
cord-316996-8yimrpaz	283	31	analysis	analysis	NN
cord-316996-8yimrpaz	283	32	of	of	IN
cord-316996-8yimrpaz	283	33	peripheral	peripheral	JJ
cord-316996-8yimrpaz	283	34	blood	blood	NN
cord-316996-8yimrpaz	283	35	T	t	NN
cord-316996-8yimrpaz	283	36	lymphocytes	lymphocyte	NNS
cord-316996-8yimrpaz	283	37	specific	specific	JJ
cord-316996-8yimrpaz	283	38	to	to	IN
cord-316996-8yimrpaz	283	39	periodontopathic	periodontopathic	JJ
cord-316996-8yimrpaz	283	40	bacteria	bacteria	NNS
cord-316996-8yimrpaz	283	41	Sialidase	Sialidase	NNP
cord-316996-8yimrpaz	283	42	fusion	fusion	NN
cord-316996-8yimrpaz	283	43	protein	protein	NN
cord-316996-8yimrpaz	283	44	as	as	IN
cord-316996-8yimrpaz	283	45	a	a	DT
cord-316996-8yimrpaz	283	46	novel	novel	JJ
cord-316996-8yimrpaz	283	47	broad	broad	JJ
cord-316996-8yimrpaz	283	48	-	-	HYPH
cord-316996-8yimrpaz	283	49	spectrum	spectrum	NN
cord-316996-8yimrpaz	283	50	inhibitor	inhibitor	NN
cord-316996-8yimrpaz	283	51	of	of	IN
cord-316996-8yimrpaz	283	52	influenza	influenza	NN
cord-316996-8yimrpaz	283	53	virus	virus	NN
cord-316996-8yimrpaz	283	54	infection	infection	NN
cord-316996-8yimrpaz	284	1	Pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	284	2	neuraminidases	neuraminidase	VBZ
cord-316996-8yimrpaz	284	3	A	a	NN
cord-316996-8yimrpaz	284	4	and	and	CC
cord-316996-8yimrpaz	284	5	B	b	NN
cord-316996-8yimrpaz	284	6	both	both	DT
cord-316996-8yimrpaz	284	7	have	have	VBP
cord-316996-8yimrpaz	284	8	essential	essential	JJ
cord-316996-8yimrpaz	284	9	roles	role	NNS
cord-316996-8yimrpaz	284	10	during	during	IN
cord-316996-8yimrpaz	284	11	infection	infection	NN
cord-316996-8yimrpaz	284	12	of	of	IN
cord-316996-8yimrpaz	284	13	the	the	DT
cord-316996-8yimrpaz	284	14	respiratory	respiratory	JJ
cord-316996-8yimrpaz	284	15	tract	tract	NN
cord-316996-8yimrpaz	284	16	and	and	CC
cord-316996-8yimrpaz	284	17	sepsis	sepsis	NN
cord-316996-8yimrpaz	284	18	Investigation	Investigation	NNP
cord-316996-8yimrpaz	284	19	of	of	IN
cord-316996-8yimrpaz	284	20	9-O	9-o	CD
cord-316996-8yimrpaz	284	21	-	-	HYPH
cord-316996-8yimrpaz	284	22	acetylated	acetylated	JJ
cord-316996-8yimrpaz	284	23	sialoglycoconjugates	sialoglycoconjugate	NNS
cord-316996-8yimrpaz	284	24	in	in	IN
cord-316996-8yimrpaz	284	25	childhood	childhood	NN
cord-316996-8yimrpaz	284	26	acute	acute	JJ
cord-316996-8yimrpaz	284	27	lymphoblastic	lymphoblastic	JJ
cord-316996-8yimrpaz	284	28	leukaemia	leukaemia	NN
cord-316996-8yimrpaz	284	29	Recombinant	Recombinant	NNP
cord-316996-8yimrpaz	284	30	influenza	influenza	NN
cord-316996-8yimrpaz	284	31	C	C	NNP
cord-316996-8yimrpaz	284	32	hemagglutininesterase	hemagglutininesterase	NN
cord-316996-8yimrpaz	284	33	as	as	IN
cord-316996-8yimrpaz	284	34	a	a	DT
cord-316996-8yimrpaz	284	35	probe	probe	NN
cord-316996-8yimrpaz	284	36	for	for	IN
cord-316996-8yimrpaz	284	37	sialic	sialic	JJ
cord-316996-8yimrpaz	284	38	acid	acid	JJ
cord-316996-8yimrpaz	284	39	9-O	9-o	CD
cord-316996-8yimrpaz	284	40	-	-	HYPH
cord-316996-8yimrpaz	284	41	acetylation	acetylation	NN
cord-316996-8yimrpaz	284	42	Neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	285	1	is	be	VBZ
cord-316996-8yimrpaz	285	2	important	important	JJ
cord-316996-8yimrpaz	285	3	for	for	IN
cord-316996-8yimrpaz	285	4	the	the	DT
cord-316996-8yimrpaz	285	5	initiation	initiation	NN
cord-316996-8yimrpaz	285	6	of	of	IN
cord-316996-8yimrpaz	285	7	influenza	influenza	NN
cord-316996-8yimrpaz	285	8	virus	virus	NN
cord-316996-8yimrpaz	285	9	infection	infection	NN
cord-316996-8yimrpaz	285	10	in	in	IN
cord-316996-8yimrpaz	285	11	human	human	JJ
cord-316996-8yimrpaz	285	12	airway	airway	NN
cord-316996-8yimrpaz	285	13	epithelium	epithelium	NN
cord-316996-8yimrpaz	285	14	Influenza	Influenza	NNP
cord-316996-8yimrpaz	285	15	enhances	enhance	VBZ
cord-316996-8yimrpaz	285	16	susceptibility	susceptibility	NN
cord-316996-8yimrpaz	285	17	to	to	IN
cord-316996-8yimrpaz	285	18	natural	natural	JJ
cord-316996-8yimrpaz	285	19	acquisition	acquisition	NN
cord-316996-8yimrpaz	285	20	of	of	IN
cord-316996-8yimrpaz	285	21	and	and	CC
cord-316996-8yimrpaz	285	22	disease	disease	NN
cord-316996-8yimrpaz	285	23	due	due	IN
cord-316996-8yimrpaz	285	24	to	to	IN
cord-316996-8yimrpaz	285	25	Streptococcus	streptococcus	NN
cord-316996-8yimrpaz	285	26	pneumoniae	pneumoniae	NN
cord-316996-8yimrpaz	285	27	in	in	IN
cord-316996-8yimrpaz	285	28	ferrets	ferret	NNS
cord-316996-8yimrpaz	286	1	A	a	DT
cord-316996-8yimrpaz	286	2	recombinant	recombinant	JJ
cord-316996-8yimrpaz	286	3	sialidase	sialidase	NN
cord-316996-8yimrpaz	286	4	fusion	fusion	NN
cord-316996-8yimrpaz	286	5	protein	protein	NN
cord-316996-8yimrpaz	286	6	effectively	effectively	RB
cord-316996-8yimrpaz	286	7	inhibits	inhibit	VBZ
cord-316996-8yimrpaz	286	8	human	human	JJ
cord-316996-8yimrpaz	286	9	parainfluenza	parainfluenza	JJ
cord-316996-8yimrpaz	286	10	viral	viral	JJ
cord-316996-8yimrpaz	286	11	infection	infection	NN
cord-316996-8yimrpaz	286	12	in	in	IN
cord-316996-8yimrpaz	286	13	vitro	vitro	FW
cord-316996-8yimrpaz	286	14	and	and	CC
cord-316996-8yimrpaz	286	15	in	in	IN
cord-316996-8yimrpaz	286	16	vivo	vivo	NNP
cord-316996-8yimrpaz	286	17	Entry	Entry	NNP
cord-316996-8yimrpaz	286	18	of	of	IN
cord-316996-8yimrpaz	286	19	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	286	20	virus	virus	NN
cord-316996-8yimrpaz	286	21	into	into	IN
cord-316996-8yimrpaz	286	22	cells	cell	NNS
cord-316996-8yimrpaz	286	23	as	as	IN
cord-316996-8yimrpaz	286	24	a	a	DT
cord-316996-8yimrpaz	286	25	target	target	NN
cord-316996-8yimrpaz	286	26	for	for	IN
cord-316996-8yimrpaz	286	27	interrupting	interrupt	VBG
cord-316996-8yimrpaz	286	28	childhood	childhood	NN
cord-316996-8yimrpaz	286	29	respiratory	respiratory	JJ
cord-316996-8yimrpaz	286	30	disease	disease	NN
cord-316996-8yimrpaz	287	1	A	a	DT
cord-316996-8yimrpaz	287	2	Phase	Phase	NNP
cord-316996-8yimrpaz	287	3	II	ii	CD
cord-316996-8yimrpaz	287	4	study	study	NN
cord-316996-8yimrpaz	287	5	of	of	IN
cord-316996-8yimrpaz	287	6	DAS181	DAS181	NNP
cord-316996-8yimrpaz	287	7	,	,	,
cord-316996-8yimrpaz	287	8	a	a	DT
cord-316996-8yimrpaz	287	9	novel	novel	JJ
cord-316996-8yimrpaz	287	10	host	host	NN
cord-316996-8yimrpaz	287	11	directed	direct	VBN
cord-316996-8yimrpaz	287	12	antiviral	antiviral	JJ
cord-316996-8yimrpaz	287	13	for	for	IN
cord-316996-8yimrpaz	287	14	the	the	DT
cord-316996-8yimrpaz	287	15	treatment	treatment	NN
cord-316996-8yimrpaz	287	16	of	of	IN
cord-316996-8yimrpaz	287	17	influenza	influenza	NN
cord-316996-8yimrpaz	287	18	infection	infection	NN
cord-316996-8yimrpaz	288	1	Proposed	propose	VBN
cord-316996-8yimrpaz	288	2	lead	lead	NN
cord-316996-8yimrpaz	288	3	molecules	molecule	NNS
cord-316996-8yimrpaz	288	4	against	against	IN
cord-316996-8yimrpaz	288	5	Hemagglutinin	Hemagglutinin	NNP
cord-316996-8yimrpaz	288	6	of	of	IN
cord-316996-8yimrpaz	288	7	avian	avian	JJ
cord-316996-8yimrpaz	288	8	influenza	influenza	NN
cord-316996-8yimrpaz	288	9	virus	virus	NN
cord-316996-8yimrpaz	288	10	(	(	-LRB-
cord-316996-8yimrpaz	288	11	H5N1	H5N1	NNP
cord-316996-8yimrpaz	288	12	)	)	-RRB-
cord-316996-8yimrpaz	289	1	Invasive	invasive	JJ
cord-316996-8yimrpaz	289	2	pneumococcal	pneumococcal	JJ
cord-316996-8yimrpaz	289	3	disease	disease	NN
cord-316996-8yimrpaz	289	4	and	and	CC
cord-316996-8yimrpaz	289	5	pandemic	pandemic	NN
cord-316996-8yimrpaz	289	6	(	(	-LRB-
cord-316996-8yimrpaz	289	7	H1N1	H1N1	NNP
cord-316996-8yimrpaz	289	8	)	)	-RRB-
cord-316996-8yimrpaz	290	1	The	the	DT
cord-316996-8yimrpaz	290	2	structure	structure	NN
cord-316996-8yimrpaz	290	3	of	of	IN
cord-316996-8yimrpaz	290	4	Clostridium	clostridium	NN
cord-316996-8yimrpaz	290	5	perfringens	perfringen	NNS
cord-316996-8yimrpaz	290	6	NanI	NanI	NNP
cord-316996-8yimrpaz	290	7	sialidase	sialidase	NN
cord-316996-8yimrpaz	290	8	and	and	CC
cord-316996-8yimrpaz	290	9	its	-PRON-	PRP$
cord-316996-8yimrpaz	290	10	catalytic	catalytic	JJ
cord-316996-8yimrpaz	290	11	intermediates	intermediate	NNS
cord-316996-8yimrpaz	290	12	Sialic	Sialic	NNP
cord-316996-8yimrpaz	290	13	acid	acid	JJ
cord-316996-8yimrpaz	290	14	receptor	receptor	NN
cord-316996-8yimrpaz	290	15	detection	detection	NN
cord-316996-8yimrpaz	290	16	in	in	IN
cord-316996-8yimrpaz	290	17	the	the	DT
cord-316996-8yimrpaz	290	18	human	human	JJ
cord-316996-8yimrpaz	290	19	respiratory	respiratory	JJ
cord-316996-8yimrpaz	290	20	tract	tract	NN
cord-316996-8yimrpaz	290	21	:	:	:
cord-316996-8yimrpaz	290	22	evidence	evidence	NN
cord-316996-8yimrpaz	290	23	for	for	IN
cord-316996-8yimrpaz	290	24	widespread	widespread	JJ
cord-316996-8yimrpaz	290	25	distribution	distribution	NN
cord-316996-8yimrpaz	290	26	of	of	IN
cord-316996-8yimrpaz	290	27	potential	potential	JJ
cord-316996-8yimrpaz	290	28	binding	bind	VBG
cord-316996-8yimrpaz	290	29	sites	site	NNS
cord-316996-8yimrpaz	290	30	for	for	IN
cord-316996-8yimrpaz	290	31	human	human	JJ
cord-316996-8yimrpaz	290	32	and	and	CC
cord-316996-8yimrpaz	290	33	avian	avian	JJ
cord-316996-8yimrpaz	290	34	influenza	influenza	NN
cord-316996-8yimrpaz	290	35	viruses	virus	NNS
cord-316996-8yimrpaz	290	36	Comment	comment	VB
cord-316996-8yimrpaz	290	37	on	on	IN
cord-316996-8yimrpaz	290	38	:	:	:
cord-316996-8yimrpaz	290	39	concerns	concern	NNS
cord-316996-8yimrpaz	290	40	of	of	IN
cord-316996-8yimrpaz	290	41	using	use	VBG
cord-316996-8yimrpaz	290	42	sialidase	sialidase	NNP
cord-316996-8yimrpaz	290	43	fusion	fusion	NN
cord-316996-8yimrpaz	290	44	protein	protein	NN
cord-316996-8yimrpaz	290	45	as	as	IN
cord-316996-8yimrpaz	290	46	an	an	DT
cord-316996-8yimrpaz	290	47	experimental	experimental	JJ
cord-316996-8yimrpaz	290	48	drug	drug	NN
cord-316996-8yimrpaz	290	49	to	to	TO
cord-316996-8yimrpaz	290	50	combat	combat	VB
cord-316996-8yimrpaz	290	51	seasonal	seasonal	JJ
cord-316996-8yimrpaz	290	52	and	and	CC
cord-316996-8yimrpaz	290	53	pandemic	pandemic	NN
cord-316996-8yimrpaz	290	54	influenza	influenza	NN
cord-316996-8yimrpaz	290	55	Sialoadhesin	Sialoadhesin	NNP
cord-316996-8yimrpaz	290	56	-A	-A	HYPH
cord-316996-8yimrpaz	290	57	macrophagerestricted	macrophagerestricted	JJ
cord-316996-8yimrpaz	290	58	marker	marker	NN
cord-316996-8yimrpaz	290	59	of	of	IN
cord-316996-8yimrpaz	290	60	immunoregulation	immunoregulation	NN
cord-316996-8yimrpaz	290	61	and	and	CC
cord-316996-8yimrpaz	290	62	inflammation	inflammation	NN
cord-316996-8yimrpaz	291	1	Glycan	glycan	JJ
cord-316996-8yimrpaz	291	2	terminator	terminator	NN
cord-316996-8yimrpaz	291	3	Restoration	Restoration	NNP
cord-316996-8yimrpaz	291	4	of	of	IN
cord-316996-8yimrpaz	291	5	specific	specific	JJ
cord-316996-8yimrpaz	291	6	myxovirus	myxovirus	JJ
cord-316996-8yimrpaz	291	7	receptors	receptor	NNS
cord-316996-8yimrpaz	291	8	to	to	IN
cord-316996-8yimrpaz	291	9	asialoerythrocytes	asialoerythrocytes	NNP
cord-316996-8yimrpaz	291	10	by	by	IN
cord-316996-8yimrpaz	291	11	incorporation	incorporation	NN
cord-316996-8yimrpaz	291	12	of	of	IN
cord-316996-8yimrpaz	291	13	sialic	sialic	JJ
cord-316996-8yimrpaz	291	14	acid	acid	NN
cord-316996-8yimrpaz	291	15	with	with	IN
cord-316996-8yimrpaz	291	16	pure	pure	JJ
cord-316996-8yimrpaz	291	17	sialyltransferases	sialyltransferase	NNS
cord-316996-8yimrpaz	291	18	Variation	variation	NN
cord-316996-8yimrpaz	291	19	in	in	IN
cord-316996-8yimrpaz	291	20	the	the	DT
cord-316996-8yimrpaz	291	21	presence	presence	NN
cord-316996-8yimrpaz	291	22	of	of	IN
cord-316996-8yimrpaz	291	23	neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	291	24	genes	gene	NNS
cord-316996-8yimrpaz	291	25	among	among	IN
cord-316996-8yimrpaz	291	26	Streptococcus	streptococcus	NN
cord-316996-8yimrpaz	291	27	pneumoniae	pneumoniae	NN
cord-316996-8yimrpaz	291	28	isolates	isolate	VBZ
cord-316996-8yimrpaz	291	29	with	with	IN
cord-316996-8yimrpaz	291	30	identical	identical	JJ
cord-316996-8yimrpaz	291	31	sequence	sequence	NN
cord-316996-8yimrpaz	291	32	types	type	NNS
cord-316996-8yimrpaz	291	33	Adherence	adherence	NN
cord-316996-8yimrpaz	291	34	of	of	IN
cord-316996-8yimrpaz	291	35	type	type	NN
cord-316996-8yimrpaz	291	36	I	-PRON-	PRP
cord-316996-8yimrpaz	291	37	Streptococcus	streptococcus	NN
cord-316996-8yimrpaz	291	38	pneumoniae	pneumoniae	NN
cord-316996-8yimrpaz	291	39	to	to	IN
cord-316996-8yimrpaz	291	40	tracheal	tracheal	JJ
cord-316996-8yimrpaz	291	41	epithelium	epithelium	NN
cord-316996-8yimrpaz	291	42	of	of	IN
cord-316996-8yimrpaz	291	43	mice	mouse	NNS
cord-316996-8yimrpaz	291	44	infected	infect	VBN
cord-316996-8yimrpaz	291	45	with	with	IN
cord-316996-8yimrpaz	291	46	influenza	influenza	NN
cord-316996-8yimrpaz	291	47	A	A	NNP
cord-316996-8yimrpaz	291	48	/	/	SYM
cord-316996-8yimrpaz	291	49	PR8	PR8	NNP
cord-316996-8yimrpaz	291	50	virus	virus	NN
cord-316996-8yimrpaz	291	51	Convergent	convergent	JJ
cord-316996-8yimrpaz	291	52	pathways	pathway	NNS
cord-316996-8yimrpaz	291	53	for	for	IN
cord-316996-8yimrpaz	291	54	utilization	utilization	NN
cord-316996-8yimrpaz	291	55	of	of	IN
cord-316996-8yimrpaz	291	56	the	the	DT
cord-316996-8yimrpaz	291	57	amino	amino	NN
cord-316996-8yimrpaz	291	58	sugars	sugar	NNS
cord-316996-8yimrpaz	291	59	N	N	NNP
cord-316996-8yimrpaz	291	60	-	-	HYPH
cord-316996-8yimrpaz	291	61	acetylglucosamine	acetylglucosamine	NNP
cord-316996-8yimrpaz	291	62	,	,	,
cord-316996-8yimrpaz	291	63	N	n	CD
cord-316996-8yimrpaz	291	64	-	-	HYPH
cord-316996-8yimrpaz	291	65	acetylmannosamine	acetylmannosamine	NN
cord-316996-8yimrpaz	291	66	,	,	,
cord-316996-8yimrpaz	291	67	and	and	CC
cord-316996-8yimrpaz	291	68	N	n	CD
cord-316996-8yimrpaz	291	69	-	-	HYPH
cord-316996-8yimrpaz	291	70	acetylneuraminic	acetylneuraminic	JJ
cord-316996-8yimrpaz	291	71	acid	acid	NN
cord-316996-8yimrpaz	291	72	by	by	IN
cord-316996-8yimrpaz	291	73	Escherichia	Escherichia	NNP
cord-316996-8yimrpaz	291	74	coli	coli	VBZ
cord-316996-8yimrpaz	291	75	Human	human	JJ
cord-316996-8yimrpaz	291	76	parainfluenza	parainfluenza	NNP
cord-316996-8yimrpaz	291	77	virus	virus	NN
cord-316996-8yimrpaz	291	78	type	type	NN
cord-316996-8yimrpaz	291	79	3	3	CD
cord-316996-8yimrpaz	291	80	HN	hn	NN
cord-316996-8yimrpaz	291	81	-	-	HYPH
cord-316996-8yimrpaz	291	82	receptor	receptor	NN
cord-316996-8yimrpaz	291	83	interaction	interaction	NN
cord-316996-8yimrpaz	291	84	:	:	:
cord-316996-8yimrpaz	291	85	effect	effect	NN
cord-316996-8yimrpaz	291	86	of	of	IN
cord-316996-8yimrpaz	291	87	4-guanidino	4-guanidino	CD
cord-316996-8yimrpaz	291	88	-	-	SYM
cord-316996-8yimrpaz	291	89	Neu5Ac2en	Neu5Ac2en	NNPS
cord-316996-8yimrpaz	291	90	on	on	IN
cord-316996-8yimrpaz	291	91	a	a	DT
cord-316996-8yimrpaz	291	92	neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	291	93	-	-	HYPH
cord-316996-8yimrpaz	291	94	deficient	deficient	JJ
cord-316996-8yimrpaz	291	95	variant	variant	NN
cord-316996-8yimrpaz	291	96	Basis	basis	NN
cord-316996-8yimrpaz	291	97	for	for	IN
cord-316996-8yimrpaz	291	98	the	the	DT
cord-316996-8yimrpaz	291	99	potent	potent	JJ
cord-316996-8yimrpaz	291	100	inhibition	inhibition	NN
cord-316996-8yimrpaz	291	101	of	of	IN
cord-316996-8yimrpaz	291	102	influenza	influenza	NN
cord-316996-8yimrpaz	291	103	virus	virus	NN
cord-316996-8yimrpaz	291	104	infection	infection	NN
cord-316996-8yimrpaz	291	105	by	by	IN
cord-316996-8yimrpaz	291	106	equine	equine	NN
cord-316996-8yimrpaz	291	107	and	and	CC
cord-316996-8yimrpaz	291	108	guinea	guinea	NN
cord-316996-8yimrpaz	291	109	pig	pig	NN
cord-316996-8yimrpaz	292	1	alpha	alpha	NN
cord-316996-8yimrpaz	292	2	2-macroglobulin	2-macroglobulin	CD
cord-316996-8yimrpaz	292	3	Recognition	Recognition	NNP
cord-316996-8yimrpaz	292	4	of	of	IN
cord-316996-8yimrpaz	292	5	monovalent	monovalent	JJ
cord-316996-8yimrpaz	292	6	sialosides	sialoside	NNS
cord-316996-8yimrpaz	292	7	by	by	IN
cord-316996-8yimrpaz	292	8	influenza	influenza	NN
cord-316996-8yimrpaz	292	9	virus	virus	NN
cord-316996-8yimrpaz	293	1	H3	H3	NNP
cord-316996-8yimrpaz	293	2	hemagglutinin	hemagglutinin	NN
cord-316996-8yimrpaz	293	3	Amino	amino	NN
cord-316996-8yimrpaz	293	4	acid	acid	NN
cord-316996-8yimrpaz	293	5	change	change	NN
cord-316996-8yimrpaz	293	6	335	335	CD
cord-316996-8yimrpaz	293	7	E	e	NN
cord-316996-8yimrpaz	293	8	to	to	IN
cord-316996-8yimrpaz	293	9	K	k	NN
cord-316996-8yimrpaz	293	10	affects	affect	VBZ
cord-316996-8yimrpaz	293	11	the	the	DT
cord-316996-8yimrpaz	293	12	sialic	sialic	JJ
cord-316996-8yimrpaz	293	13	-	-	HYPH
cord-316996-8yimrpaz	293	14	acid	acid	NN
cord-316996-8yimrpaz	293	15	-	-	HYPH
cord-316996-8yimrpaz	293	16	binding	binding	NN
cord-316996-8yimrpaz	293	17	and	and	CC
cord-316996-8yimrpaz	293	18	neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	293	19	activities	activity	NNS
cord-316996-8yimrpaz	293	20	of	of	IN
cord-316996-8yimrpaz	293	21	Urabe	Urabe	NNP
cord-316996-8yimrpaz	293	22	AM9	AM9	NNP
cord-316996-8yimrpaz	293	23	mumps	mumps	NN
cord-316996-8yimrpaz	293	24	virus	virus	NN
cord-316996-8yimrpaz	293	25	hemagglutinin	hemagglutinin	NN
cord-316996-8yimrpaz	293	26	-	-	:
cord-316996-8yimrpaz	293	27	neuraminidase	neuraminidase	NN
cord-316996-8yimrpaz	293	28	glycoprotein	glycoprotein	NN
cord-316996-8yimrpaz	293	29	Receptor	receptor	NN
cord-316996-8yimrpaz	293	30	determinants	determinant	NNS
cord-316996-8yimrpaz	293	31	of	of	IN
cord-316996-8yimrpaz	293	32	human	human	JJ
cord-316996-8yimrpaz	293	33	and	and	CC
cord-316996-8yimrpaz	293	34	animal	animal	NN
cord-316996-8yimrpaz	293	35	influenza	influenza	NN
cord-316996-8yimrpaz	293	36	virus	virus	NN
cord-316996-8yimrpaz	293	37	isolates	isolate	VBZ
cord-316996-8yimrpaz	293	38	:	:	:
cord-316996-8yimrpaz	293	39	differences	difference	NNS
cord-316996-8yimrpaz	293	40	in	in	IN
cord-316996-8yimrpaz	293	41	receptor	receptor	NN
cord-316996-8yimrpaz	293	42	specificity	specificity	NN
cord-316996-8yimrpaz	293	43	of	of	IN
cord-316996-8yimrpaz	293	44	the	the	DT
cord-316996-8yimrpaz	293	45	H3	H3	NNP
cord-316996-8yimrpaz	293	46	hemagglutinin	hemagglutinin	NN
cord-316996-8yimrpaz	293	47	based	base	VBN
cord-316996-8yimrpaz	293	48	on	on	IN
cord-316996-8yimrpaz	293	49	species	specie	NNS
cord-316996-8yimrpaz	293	50	of	of	IN
cord-316996-8yimrpaz	293	51	origin	origin	NN
cord-316996-8yimrpaz	293	52	Differential	differential	JJ
cord-316996-8yimrpaz	293	53	sensitivity	sensitivity	NN
cord-316996-8yimrpaz	293	54	of	of	IN
cord-316996-8yimrpaz	293	55	human	human	NN
cord-316996-8yimrpaz	293	56	,	,	,
cord-316996-8yimrpaz	293	57	avian	avian	JJ
cord-316996-8yimrpaz	293	58	,	,	,
cord-316996-8yimrpaz	293	59	and	and	CC
cord-316996-8yimrpaz	293	60	equine	equine	NN
cord-316996-8yimrpaz	293	61	influenza	influenza	NN
cord-316996-8yimrpaz	293	62	A	a	DT
cord-316996-8yimrpaz	293	63	viruses	virus	NNS
cord-316996-8yimrpaz	293	64	to	to	IN
cord-316996-8yimrpaz	293	65	a	a	DT
cord-316996-8yimrpaz	293	66	glycoprotein	glycoprotein	NN
cord-316996-8yimrpaz	293	67	inhibitor	inhibitor	NN
cord-316996-8yimrpaz	293	68	of	of	IN
cord-316996-8yimrpaz	293	69	infection	infection	NN
cord-316996-8yimrpaz	293	70	:	:	:
cord-316996-8yimrpaz	293	71	selection	selection	NN
cord-316996-8yimrpaz	293	72	of	of	IN
cord-316996-8yimrpaz	293	73	receptor	receptor	NN
cord-316996-8yimrpaz	293	74	specific	specific	JJ
cord-316996-8yimrpaz	293	75	variants	variant	NNS
cord-316996-8yimrpaz	293	76	O	o	NN
cord-316996-8yimrpaz	293	77	-	-	HYPH
cord-316996-8yimrpaz	293	78	Acetylated	acetylated	JJ
cord-316996-8yimrpaz	293	79	sialic	sialic	JJ
cord-316996-8yimrpaz	293	80	acids	acid	NNS
cord-316996-8yimrpaz	293	81	and	and	CC
cord-316996-8yimrpaz	293	82	their	-PRON-	PRP$
cord-316996-8yimrpaz	293	83	role	role	NN
cord-316996-8yimrpaz	293	84	in	in	IN
cord-316996-8yimrpaz	293	85	immune	immune	JJ
cord-316996-8yimrpaz	293	86	defense	defense	NN
cord-316996-8yimrpaz	293	87	Chemistry	chemistry	NN
cord-316996-8yimrpaz	293	88	and	and	CC
cord-316996-8yimrpaz	293	89	biology	biology	NN
cord-316996-8yimrpaz	293	90	of	of	IN
cord-316996-8yimrpaz	293	91	the	the	DT
cord-316996-8yimrpaz	293	92	acylneuraminic	acylneuraminic	JJ
cord-316996-8yimrpaz	293	93	acids	acid	NNS
cord-316996-8yimrpaz	293	94	Achievements	achievement	NNS
cord-316996-8yimrpaz	293	95	and	and	CC
cord-316996-8yimrpaz	293	96	challenges	challenge	NNS
cord-316996-8yimrpaz	293	97	of	of	IN
cord-316996-8yimrpaz	293	98	sialic	sialic	JJ
cord-316996-8yimrpaz	293	99	acid	acid	NN
cord-316996-8yimrpaz	293	100	research	research	NN
cord-316996-8yimrpaz	293	101	Amphiregulin	Amphiregulin	NNP
cord-316996-8yimrpaz	293	102	:	:	:
cord-316996-8yimrpaz	293	103	a	a	DT
cord-316996-8yimrpaz	293	104	bifunctional	bifunctional	JJ
cord-316996-8yimrpaz	293	105	growth	growth	NN
cord-316996-8yimrpaz	293	106	-	-	HYPH
cord-316996-8yimrpaz	293	107	modulating	modulate	VBG
cord-316996-8yimrpaz	293	108	glycoprotein	glycoprotein	NN
cord-316996-8yimrpaz	293	109	produced	produce	VBN
cord-316996-8yimrpaz	293	110	by	by	IN
cord-316996-8yimrpaz	293	111	the	the	DT
cord-316996-8yimrpaz	293	112	phorbol	phorbol	NN
cord-316996-8yimrpaz	293	113	12-myristate	12-myristate	CD
cord-316996-8yimrpaz	293	114	13-acetate	13-acetate	CD
cord-316996-8yimrpaz	293	115	-	-	HYPH
cord-316996-8yimrpaz	293	116	treated	treat	VBN
cord-316996-8yimrpaz	293	117	human	human	JJ
cord-316996-8yimrpaz	293	118	breast	breast	NN
cord-316996-8yimrpaz	293	119	adenocarcinoma	adenocarcinoma	NN
cord-316996-8yimrpaz	293	120	cell	cell	NN
cord-316996-8yimrpaz	293	121	line	line	NN
cord-316996-8yimrpaz	294	1	MCF-7	MCF-7	NNP
cord-316996-8yimrpaz	294	2	A	a	DT
cord-316996-8yimrpaz	294	3	sialylated	sialylate	VBN
cord-316996-8yimrpaz	294	4	glycan	glycan	NN
cord-316996-8yimrpaz	294	5	microarray	microarray	NN
cord-316996-8yimrpaz	294	6	reveals	reveal	VBZ
cord-316996-8yimrpaz	294	7	novel	novel	JJ
cord-316996-8yimrpaz	294	8	interactions	interaction	NNS
cord-316996-8yimrpaz	294	9	of	of	IN
cord-316996-8yimrpaz	294	10	modified	modify	VBN
cord-316996-8yimrpaz	294	11	sialic	sialic	NN
cord-316996-8yimrpaz	294	12	acids	acid	NNS
cord-316996-8yimrpaz	294	13	with	with	IN
cord-316996-8yimrpaz	294	14	proteins	protein	NNS
cord-316996-8yimrpaz	294	15	and	and	CC
cord-316996-8yimrpaz	294	16	viruses	virus	NNS
cord-316996-8yimrpaz	294	17	Minimal	minimal	JJ
cord-316996-8yimrpaz	294	18	molecular	molecular	JJ
cord-316996-8yimrpaz	294	19	constraints	constraint	NNS
cord-316996-8yimrpaz	294	20	for	for	IN
cord-316996-8yimrpaz	294	21	respiratory	respiratory	JJ
cord-316996-8yimrpaz	294	22	droplet	droplet	NN
cord-316996-8yimrpaz	294	23	transmission	transmission	NN
cord-316996-8yimrpaz	294	24	of	of	IN
cord-316996-8yimrpaz	294	25	an	an	DT
cord-316996-8yimrpaz	294	26	avian	avian	JJ
cord-316996-8yimrpaz	294	27	-	-	HYPH
cord-316996-8yimrpaz	294	28	human	human	JJ
cord-316996-8yimrpaz	294	29	H9N2	H9N2	NNP
cord-316996-8yimrpaz	294	30	influenza	influenza	NN
cord-316996-8yimrpaz	294	31	A	a	DT
cord-316996-8yimrpaz	294	32	virus	virus	NN
cord-316996-8yimrpaz	295	1	The	the	DT
cord-316996-8yimrpaz	295	2	induction	induction	NN
cord-316996-8yimrpaz	295	3	of	of	IN
cord-316996-8yimrpaz	295	4	oral	oral	JJ
cord-316996-8yimrpaz	295	5	tolerance	tolerance	NN
cord-316996-8yimrpaz	295	6	to	to	IN
cord-316996-8yimrpaz	295	7	Actinomyces	Actinomyces	NNP
cord-316996-8yimrpaz	295	8	viscosus	viscosus	NN
cord-316996-8yimrpaz	295	9	in	in	IN
cord-316996-8yimrpaz	295	10	mice	mouse	NNS
cord-316996-8yimrpaz	295	11	Inactivation	Inactivation	NNP
cord-316996-8yimrpaz	295	12	of	of	IN
cord-316996-8yimrpaz	295	13	human	human	JJ
cord-316996-8yimrpaz	295	14	erythrocyte	erythrocyte	NN
cord-316996-8yimrpaz	295	15	agglutinogens	agglutinogens	NNP
cord-316996-8yimrpaz	295	16	M	M	NNP
cord-316996-8yimrpaz	295	17	and	and	CC
cord-316996-8yimrpaz	295	18	N	N	NNP
cord-316996-8yimrpaz	295	19	by	by	IN
cord-316996-8yimrpaz	295	20	influenza	influenza	NN
cord-316996-8yimrpaz	295	21	viruses	virus	NNS
cord-316996-8yimrpaz	295	22	and	and	CC
cord-316996-8yimrpaz	295	23	receptor	receptor	NN
cord-316996-8yimrpaz	295	24	-	-	HYPH
cord-316996-8yimrpaz	295	25	destroying	destroy	VBG
cord-316996-8yimrpaz	295	26	enzyme	enzyme	NN
cord-316996-8yimrpaz	295	27	Sialic	Sialic	NNP
cord-316996-8yimrpaz	295	28	acid	acid	NN
cord-316996-8yimrpaz	295	29	,	,	,
cord-316996-8yimrpaz	295	30	periodontal	periodontal	JJ
cord-316996-8yimrpaz	295	31	pathogens	pathogen	NNS
cord-316996-8yimrpaz	295	32	and	and	CC
cord-316996-8yimrpaz	295	33	Tannerella	Tannerella	NNP
cord-316996-8yimrpaz	295	34	forsythia	forsythia	NN
cord-316996-8yimrpaz	295	35	:	:	:
cord-316996-8yimrpaz	295	36	stick	stick	VB
cord-316996-8yimrpaz	295	37	around	around	RB
cord-316996-8yimrpaz	295	38	and	and	CC
cord-316996-8yimrpaz	295	39	enjoy	enjoy	VB
cord-316996-8yimrpaz	295	40	the	the	DT
cord-316996-8yimrpaz	295	41	feast	feast	NN
cord-316996-8yimrpaz	295	42	!	!	.
cord-316996-8yimrpaz	296	1	Mol	Mol	NNP
cord-316996-8yimrpaz	296	2	Glycosylation	Glycosylation	NNP
cord-316996-8yimrpaz	296	3	site	site	NN
cord-316996-8yimrpaz	296	4	alteration	alteration	NN
cord-316996-8yimrpaz	296	5	in	in	IN
cord-316996-8yimrpaz	296	6	the	the	DT
cord-316996-8yimrpaz	296	7	evolution	evolution	NN
cord-316996-8yimrpaz	296	8	of	of	IN
cord-316996-8yimrpaz	296	9	influenza	influenza	NN
cord-316996-8yimrpaz	296	10	A	a	NN
cord-316996-8yimrpaz	296	11	(	(	-LRB-
cord-316996-8yimrpaz	296	12	H1N1	H1N1	NNP
cord-316996-8yimrpaz	296	13	)	)	-RRB-
cord-316996-8yimrpaz	296	14	viruses	viruse	VBZ
cord-316996-8yimrpaz	296	15	Receptor	receptor	NN
cord-316996-8yimrpaz	296	16	specificities	specificity	NNS
cord-316996-8yimrpaz	296	17	of	of	IN
cord-316996-8yimrpaz	296	18	human	human	JJ
cord-316996-8yimrpaz	296	19	respiroviruses	respiroviruse	NNS
cord-316996-8yimrpaz	296	20	Human	Human	NNP
cord-316996-8yimrpaz	296	21	cytomegalovirus	cytomegalovirus	NN
cord-316996-8yimrpaz	296	22	binding	bind	VBG
cord-316996-8yimrpaz	296	23	to	to	IN
cord-316996-8yimrpaz	296	24	fibroblasts	fibroblast	NNS
cord-316996-8yimrpaz	296	25	is	be	VBZ
cord-316996-8yimrpaz	296	26	receptor	receptor	NN
cord-316996-8yimrpaz	296	27	mediated	mediate	VBN
cord-316996-8yimrpaz	296	28	Properties	Properties	NNP
cord-316996-8yimrpaz	296	29	of	of	IN
cord-316996-8yimrpaz	296	30	sialidase	sialidase	NN
cord-316996-8yimrpaz	296	31	isolated	isolate	VBN
cord-316996-8yimrpaz	296	32	from	from	IN
cord-316996-8yimrpaz	296	33	Actinomyces	Actinomyces	NNP
cord-316996-8yimrpaz	296	34	viscosus	viscosus	NN
cord-316996-8yimrpaz	296	35	DSM	DSM	NNP
cord-316996-8yimrpaz	296	36	43798	43798	CD
cord-316996-8yimrpaz	296	37	Infection	infection	NN
cord-316996-8yimrpaz	296	38	of	of	IN
cord-316996-8yimrpaz	296	39	human	human	JJ
cord-316996-8yimrpaz	296	40	airway	airway	NN
cord-316996-8yimrpaz	296	41	epithelium	epithelium	NN
cord-316996-8yimrpaz	296	42	by	by	IN
cord-316996-8yimrpaz	296	43	human	human	JJ
cord-316996-8yimrpaz	296	44	and	and	CC
cord-316996-8yimrpaz	296	45	avian	avian	JJ
cord-316996-8yimrpaz	296	46	strains	strain	NNS
cord-316996-8yimrpaz	296	47	of	of	IN
cord-316996-8yimrpaz	296	48	influenza	influenza	NN
cord-316996-8yimrpaz	296	49	a	a	DT
cord-316996-8yimrpaz	296	50	virus	virus	NN
cord-316996-8yimrpaz	296	51	DAS181	DAS181	NNP
cord-316996-8yimrpaz	296	52	,	,	,
cord-316996-8yimrpaz	296	53	a	a	DT
cord-316996-8yimrpaz	296	54	sialidase	sialidase	NN
cord-316996-8yimrpaz	296	55	fusion	fusion	NN
cord-316996-8yimrpaz	296	56	protein	protein	NN
cord-316996-8yimrpaz	296	57	,	,	,
cord-316996-8yimrpaz	296	58	protects	protect	VBZ
cord-316996-8yimrpaz	296	59	human	human	JJ
cord-316996-8yimrpaz	296	60	airway	airway	NN
cord-316996-8yimrpaz	296	61	epithelium	epithelium	NN
cord-316996-8yimrpaz	296	62	against	against	IN
cord-316996-8yimrpaz	296	63	influenza	influenza	NN
cord-316996-8yimrpaz	296	64	virus	virus	NN
cord-316996-8yimrpaz	296	65	infection	infection	NN
cord-316996-8yimrpaz	296	66	:	:	:
cord-316996-8yimrpaz	296	67	an	an	DT
cord-316996-8yimrpaz	296	68	in	in	FW
cord-316996-8yimrpaz	296	69	vitro	vitro	FW
cord-316996-8yimrpaz	296	70	pharmacodynamic	pharmacodynamic	JJ
cord-316996-8yimrpaz	296	71	analysis	analysis	NN
cord-316996-8yimrpaz	296	72	Involvement	Involvement	NNP
cord-316996-8yimrpaz	296	73	of	of	IN
cord-316996-8yimrpaz	296	74	the	the	DT
cord-316996-8yimrpaz	296	75	platelet	platelet	NN
cord-316996-8yimrpaz	296	76	-	-	HYPH
cord-316996-8yimrpaz	296	77	activating	activate	VBG
cord-316996-8yimrpaz	296	78	factor	factor	NN
cord-316996-8yimrpaz	296	79	receptor	receptor	NN
cord-316996-8yimrpaz	296	80	in	in	IN
cord-316996-8yimrpaz	296	81	host	host	NN
cord-316996-8yimrpaz	296	82	defense	defense	NN
cord-316996-8yimrpaz	296	83	against	against	IN
cord-316996-8yimrpaz	296	84	Streptococcus	Streptococcus	NNP
cord-316996-8yimrpaz	296	85	pneumoniae	pneumoniae	NN
cord-316996-8yimrpaz	296	86	during	during	IN
cord-316996-8yimrpaz	296	87	postinfluenza	postinfluenza	NNP
cord-316996-8yimrpaz	296	88	pneumonia	pneumonia	NN
cord-316996-8yimrpaz	296	89	Multifarious	multifarious	JJ
cord-316996-8yimrpaz	296	90	roles	role	NNS
cord-316996-8yimrpaz	296	91	of	of	IN
cord-316996-8yimrpaz	296	92	sialic	sialic	JJ
cord-316996-8yimrpaz	296	93	acids	acid	NNS
cord-316996-8yimrpaz	296	94	in	in	IN
cord-316996-8yimrpaz	296	95	immunity	immunity	NN
cord-316996-8yimrpaz	296	96	Diversity	diversity	NN
cord-316996-8yimrpaz	296	97	in	in	IN
cord-316996-8yimrpaz	296	98	cell	cell	NN
cord-316996-8yimrpaz	296	99	surface	surface	NN
cord-316996-8yimrpaz	296	100	sialic	sialic	NN
cord-316996-8yimrpaz	296	101	acid	acid	NN
cord-316996-8yimrpaz	296	102	presentations	presentation	NNS
cord-316996-8yimrpaz	296	103	:	:	:
cord-316996-8yimrpaz	296	104	implications	implication	NNS
cord-316996-8yimrpaz	296	105	for	for	IN
cord-316996-8yimrpaz	296	106	biology	biology	NN
cord-316996-8yimrpaz	296	107	and	and	CC
cord-316996-8yimrpaz	296	108	disease	disease	NN
cord-316996-8yimrpaz	296	109	Sialic	Sialic	NNP
cord-316996-8yimrpaz	296	110	acids	acid	NNS
cord-316996-8yimrpaz	296	111	as	as	IN
cord-316996-8yimrpaz	296	112	ligands	ligand	NNS
cord-316996-8yimrpaz	296	113	in	in	IN
cord-316996-8yimrpaz	296	114	recognition	recognition	NN
cord-316996-8yimrpaz	296	115	phenomena	phenomena	JJ
cord-316996-8yimrpaz	296	116	Role	role	NN
cord-316996-8yimrpaz	296	117	of	of	IN
cord-316996-8yimrpaz	296	118	sialic	sialic	JJ
cord-316996-8yimrpaz	296	119	acid	acid	NN
cord-316996-8yimrpaz	296	120	-	-	HYPH
cord-316996-8yimrpaz	296	121	containing	contain	VBG
cord-316996-8yimrpaz	296	122	molecules	molecule	NNS
cord-316996-8yimrpaz	296	123	in	in	IN
cord-316996-8yimrpaz	296	124	paramyxovirus	paramyxovirus	JJ
cord-316996-8yimrpaz	296	125	entry	entry	NN
cord-316996-8yimrpaz	296	126	into	into	IN
cord-316996-8yimrpaz	296	127	the	the	DT
cord-316996-8yimrpaz	296	128	host	host	NN
cord-316996-8yimrpaz	296	129	cell	cell	NN
cord-316996-8yimrpaz	296	130	:	:	:
cord-316996-8yimrpaz	296	131	a	a	DT
cord-316996-8yimrpaz	296	132	minireview	minireview	NN
cord-316996-8yimrpaz	296	133	Diversity	diversity	NN
cord-316996-8yimrpaz	296	134	of	of	IN
cord-316996-8yimrpaz	296	135	microbial	microbial	JJ
cord-316996-8yimrpaz	296	136	sialic	sialic	NN
cord-316996-8yimrpaz	296	137	acid	acid	NN
cord-316996-8yimrpaz	296	138	metabolism	metabolism	NN
cord-316996-8yimrpaz	296	139	.	.	.
cord-316996-8yimrpaz	297	1	Microbiol	Microbiol	NNP
cord-316996-8yimrpaz	297	2	Microbial	Microbial	NNP
cord-316996-8yimrpaz	297	3	sialidases	sialidase	NNS
cord-316996-8yimrpaz	297	4	:	:	:
cord-316996-8yimrpaz	297	5	does	do	VBZ
cord-316996-8yimrpaz	297	6	bigger	big	JJR
cord-316996-8yimrpaz	297	7	always	always	RB
cord-316996-8yimrpaz	297	8	mean	mean	VB
cord-316996-8yimrpaz	297	9	better	well	JJR
cord-316996-8yimrpaz	297	10	?	?	.
cord-316996-8yimrpaz	298	1	Ten	ten	CD
cord-316996-8yimrpaz	298	2	years	year	NNS
cord-316996-8yimrpaz	298	3	'	'	POS
cord-316996-8yimrpaz	298	4	experience	experience	NN
cord-316996-8yimrpaz	298	5	with	with	IN
cord-316996-8yimrpaz	298	6	year	year	NN
cord-316996-8yimrpaz	298	7	-	-	HYPH
cord-316996-8yimrpaz	298	8	round	round	JJ
cord-316996-8yimrpaz	298	9	active	active	JJ
cord-316996-8yimrpaz	298	10	surveillance	surveillance	NN
cord-316996-8yimrpaz	298	11	of	of	IN
cord-316996-8yimrpaz	298	12	up	up	IN
cord-316996-8yimrpaz	298	13	to	to	TO
cord-316996-8yimrpaz	298	14	19	19	CD
cord-316996-8yimrpaz	298	15	respiratory	respiratory	JJ
cord-316996-8yimrpaz	298	16	pathogens	pathogen	NNS
cord-316996-8yimrpaz	298	17	in	in	IN
cord-316996-8yimrpaz	298	18	children	child	NNS
cord-316996-8yimrpaz	298	19	Structure	Structure	NNP
cord-316996-8yimrpaz	298	20	of	of	IN
cord-316996-8yimrpaz	298	21	the	the	DT
cord-316996-8yimrpaz	298	22	influenza	influenza	NN
cord-316996-8yimrpaz	298	23	virus	virus	NN
cord-316996-8yimrpaz	298	24	haemagglutinin	haemagglutinin	NNP
cord-316996-8yimrpaz	298	25	complexed	complexe	VBN
cord-316996-8yimrpaz	298	26	with	with	IN
cord-316996-8yimrpaz	298	27	its	-PRON-	PRP$
cord-316996-8yimrpaz	298	28	receptor	receptor	NN
cord-316996-8yimrpaz	298	29	,	,	,
cord-316996-8yimrpaz	298	30	sialic	sialic	NN
cord-316996-8yimrpaz	298	31	acid	acid	NN
cord-316996-8yimrpaz	298	32	A	a	DT
cord-316996-8yimrpaz	298	33	review	review	NN
cord-316996-8yimrpaz	298	34	of	of	IN
cord-316996-8yimrpaz	298	35	influenza	influenza	NN
cord-316996-8yimrpaz	298	36	haemagglutinin	haemagglutinin	NNP
cord-316996-8yimrpaz	298	37	receptor	receptor	NN
cord-316996-8yimrpaz	298	38	binding	bind	VBG
cord-316996-8yimrpaz	298	39	as	as	IN
cord-316996-8yimrpaz	298	40	it	-PRON-	PRP
cord-316996-8yimrpaz	298	41	relates	relate	VBZ
cord-316996-8yimrpaz	298	42	to	to	IN
cord-316996-8yimrpaz	298	43	pandemic	pandemic	NN
cord-316996-8yimrpaz	298	44	properties	property	NNS
cord-316996-8yimrpaz	298	45	Altered	alter	VBD
cord-316996-8yimrpaz	298	46	EGFR	EGFR	NNP
cord-316996-8yimrpaz	298	47	localization	localization	NN
cord-316996-8yimrpaz	298	48	and	and	CC
cord-316996-8yimrpaz	298	49	degradation	degradation	NN
cord-316996-8yimrpaz	298	50	in	in	IN
cord-316996-8yimrpaz	298	51	human	human	JJ
cord-316996-8yimrpaz	298	52	breast	breast	NN
cord-316996-8yimrpaz	298	53	cancer	cancer	NN
cord-316996-8yimrpaz	298	54	cells	cell	NNS
cord-316996-8yimrpaz	298	55	with	with	IN
cord-316996-8yimrpaz	298	56	an	an	DT
cord-316996-8yimrpaz	298	57	amphiregulin	amphiregulin	NN
cord-316996-8yimrpaz	298	58	/	/	SYM
cord-316996-8yimrpaz	298	59	EGFR	EGFR	NNP
cord-316996-8yimrpaz	298	60	autocrine	autocrine	NN
cord-316996-8yimrpaz	298	61	loop	loop	NN
cord-316996-8yimrpaz	298	62	Altered	alter	VBN
cord-316996-8yimrpaz	298	63	Oglycosylation	Oglycosylation	NNP
cord-316996-8yimrpaz	298	64	and	and	CC
cord-316996-8yimrpaz	298	65	sulfation	sulfation	NN
cord-316996-8yimrpaz	298	66	of	of	IN
cord-316996-8yimrpaz	298	67	airway	airway	NN
cord-316996-8yimrpaz	298	68	mucins	mucin	NNS
cord-316996-8yimrpaz	298	69	associated	associate	VBN
cord-316996-8yimrpaz	298	70	with	with	IN
cord-316996-8yimrpaz	298	71	cystic	cystic	JJ
cord-316996-8yimrpaz	298	72	fibrosis	fibrosis	NN
cord-316996-8yimrpaz	298	73	Concerns	concern	NNS
cord-316996-8yimrpaz	298	74	of	of	IN
cord-316996-8yimrpaz	298	75	using	use	VBG
cord-316996-8yimrpaz	298	76	sialidase	sialidase	NN
cord-316996-8yimrpaz	298	77	fusion	fusion	NN
cord-316996-8yimrpaz	298	78	protein	protein	NN
cord-316996-8yimrpaz	298	79	as	as	IN
cord-316996-8yimrpaz	298	80	an	an	DT
cord-316996-8yimrpaz	298	81	experimental	experimental	JJ
cord-316996-8yimrpaz	298	82	drug	drug	NN
cord-316996-8yimrpaz	298	83	to	to	TO
cord-316996-8yimrpaz	298	84	combat	combat	VB
cord-316996-8yimrpaz	298	85	seasonal	seasonal	JJ
cord-316996-8yimrpaz	298	86	and	and	CC
cord-316996-8yimrpaz	298	87	pandemic	pandemic	NN
cord-316996-8yimrpaz	298	88	influenza	influenza	NN