id sid tid token lemma pos cord-008761-b36x05fn 1 1 key key JJ cord-008761-b36x05fn 1 2 : : : cord-008761-b36x05fn 1 3 cord-008761-b36x05fn cord-008761-b36x05fn NN cord-008761-b36x05fn 1 4 authors author NNS cord-008761-b36x05fn 1 5 : : : cord-008761-b36x05fn 1 6 Billiau Billiau NNP cord-008761-b36x05fn 1 7 , , , cord-008761-b36x05fn 1 8 A. a. NN cord-008761-b36x05fn 1 9 title title NN cord-008761-b36x05fn 1 10 : : : cord-008761-b36x05fn 1 11 The the DT cord-008761-b36x05fn 1 12 interferon interferon NN cord-008761-b36x05fn 1 13 system system NN cord-008761-b36x05fn 1 14 as as IN cord-008761-b36x05fn 1 15 a a DT cord-008761-b36x05fn 1 16 basis basis NN cord-008761-b36x05fn 1 17 for for IN cord-008761-b36x05fn 1 18 antiviral antiviral JJ cord-008761-b36x05fn 1 19 therapy therapy NN cord-008761-b36x05fn 1 20 or or CC cord-008761-b36x05fn 1 21 prophylaxis prophylaxis NN cord-008761-b36x05fn 1 22 date date NN cord-008761-b36x05fn 1 23 : : : cord-008761-b36x05fn 1 24 2012 2012 CD cord-008761-b36x05fn 1 25 - - HYPH cord-008761-b36x05fn 1 26 02 02 CD cord-008761-b36x05fn 1 27 - - SYM cord-008761-b36x05fn 1 28 26 26 CD cord-008761-b36x05fn 1 29 journal journal NN cord-008761-b36x05fn 1 30 : : : cord-008761-b36x05fn 2 1 Antiviral antiviral JJ cord-008761-b36x05fn 2 2 Res res NN cord-008761-b36x05fn 2 3 DOI doi NN cord-008761-b36x05fn 2 4 : : : cord-008761-b36x05fn 3 1 10.1016 10.1016 CD cord-008761-b36x05fn 3 2 / / SYM cord-008761-b36x05fn 3 3 s0166 s0166 JJ cord-008761-b36x05fn 3 4 - - HYPH cord-008761-b36x05fn 3 5 3542(85)80020 3542(85)80020 NNP cord-008761-b36x05fn 3 6 - - HYPH cord-008761-b36x05fn 3 7 6 6 CD cord-008761-b36x05fn 3 8 sha sha NNP cord-008761-b36x05fn 3 9 : : : cord-008761-b36x05fn 4 1 6a1b0f4f069d10c9ecf24ef25938de85ac5077c8 6a1b0f4f069d10c9ecf24ef25938de85ac5077c8 CD cord-008761-b36x05fn 4 2 doc_id doc_id CD cord-008761-b36x05fn 4 3 : : : cord-008761-b36x05fn 5 1 8761 8761 CD cord-008761-b36x05fn 5 2 cord_uid cord_uid NNS cord-008761-b36x05fn 5 3 : : : cord-008761-b36x05fn 6 1 b36x05fn b36x05fn NNP cord-008761-b36x05fn 6 2 nan nan NNP cord-008761-b36x05fn 7 1 The the DT cord-008761-b36x05fn 7 2 interferon interferon NN cord-008761-b36x05fn 7 3 system system NN cord-008761-b36x05fn 7 4 is be VBZ cord-008761-b36x05fn 7 5 part part NN cord-008761-b36x05fn 7 6 of of IN cord-008761-b36x05fn 7 7 the the DT cord-008761-b36x05fn 7 8 so so RB cord-008761-b36x05fn 7 9 - - HYPH cord-008761-b36x05fn 7 10 called call VBN cord-008761-b36x05fn 7 11 aspecific aspecific NNP cord-008761-b36x05fn 7 12 defense defense NN cord-008761-b36x05fn 7 13 mechanism mechanism NN cord-008761-b36x05fn 7 14 of of IN cord-008761-b36x05fn 7 15 vertebrates vertebrate NNS cord-008761-b36x05fn 7 16 against against IN cord-008761-b36x05fn 7 17 virus virus NN cord-008761-b36x05fn 7 18 infections infection NNS cord-008761-b36x05fn 7 19 . . . cord-008761-b36x05fn 8 1 The the DT cord-008761-b36x05fn 8 2 term term NN cord-008761-b36x05fn 8 3 " " `` cord-008761-b36x05fn 8 4 aspecific aspecific NN cord-008761-b36x05fn 8 5 " " '' cord-008761-b36x05fn 8 6 mainly mainly RB cord-008761-b36x05fn 8 7 refers refer VBZ cord-008761-b36x05fn 8 8 to to IN cord-008761-b36x05fn 8 9 the the DT cord-008761-b36x05fn 8 10 fact fact NN cord-008761-b36x05fn 8 11 that that IN cord-008761-b36x05fn 8 12 the the DT cord-008761-b36x05fn 8 13 system system NN cord-008761-b36x05fn 8 14 is be VBZ cord-008761-b36x05fn 8 15 operative operative JJ cord-008761-b36x05fn 8 16 against against IN cord-008761-b36x05fn 8 17 all all DT cord-008761-b36x05fn 8 18 taxonomic taxonomic JJ cord-008761-b36x05fn 8 19 classes class NNS cord-008761-b36x05fn 8 20 of of IN cord-008761-b36x05fn 8 21 viruses virus NNS cord-008761-b36x05fn 8 22 . . . cord-008761-b36x05fn 9 1 It -PRON- PRP cord-008761-b36x05fn 9 2 consists consist VBZ cord-008761-b36x05fn 9 3 of of IN cord-008761-b36x05fn 9 4 a a DT cord-008761-b36x05fn 9 5 set set NN cord-008761-b36x05fn 9 6 of of IN cord-008761-b36x05fn 9 7 evolutionary evolutionary JJ cord-008761-b36x05fn 9 8 related relate VBN cord-008761-b36x05fn 9 9 proteins protein NNS cord-008761-b36x05fn 9 10 , , , cord-008761-b36x05fn 9 11 interferons interferon NNS cord-008761-b36x05fn 9 12 , , , cord-008761-b36x05fn 9 13 which which WDT cord-008761-b36x05fn 9 14 possess possess VBP cord-008761-b36x05fn 9 15 the the DT cord-008761-b36x05fn 9 16 ability ability NN cord-008761-b36x05fn 9 17 to to TO cord-008761-b36x05fn 9 18 tune tune VB cord-008761-b36x05fn 9 19 the the DT cord-008761-b36x05fn 9 20 synthetic synthetic JJ cord-008761-b36x05fn 9 21 biochemistry biochemistry NN cord-008761-b36x05fn 9 22 of of IN cord-008761-b36x05fn 9 23 the the DT cord-008761-b36x05fn 9 24 cell cell NN cord-008761-b36x05fn 9 25 so so IN cord-008761-b36x05fn 9 26 that that IN cord-008761-b36x05fn 9 27 various various JJ cord-008761-b36x05fn 9 28 processes process NNS cord-008761-b36x05fn 9 29 which which WDT cord-008761-b36x05fn 9 30 are be VBP cord-008761-b36x05fn 9 31 essential essential JJ cord-008761-b36x05fn 9 32 for for IN cord-008761-b36x05fn 9 33 virus virus NN cord-008761-b36x05fn 9 34 replication replication NN cord-008761-b36x05fn 9 35 are be VBP cord-008761-b36x05fn 9 36 impaired impair VBN cord-008761-b36x05fn 9 37 . . . cord-008761-b36x05fn 10 1 Under under IN cord-008761-b36x05fn 10 2 " " `` cord-008761-b36x05fn 10 3 normal normal JJ cord-008761-b36x05fn 10 4 " " '' cord-008761-b36x05fn 10 5 conditions condition NNS cord-008761-b36x05fn 10 6 the the DT cord-008761-b36x05fn 10 7 organism organism NN cord-008761-b36x05fn 10 8 synthesizes synthesize VBZ cord-008761-b36x05fn 10 9 or or CC cord-008761-b36x05fn 10 10 releases release VBZ cord-008761-b36x05fn 10 11 little little JJ cord-008761-b36x05fn 10 12 if if IN cord-008761-b36x05fn 10 13 any any DT cord-008761-b36x05fn 10 14 of of IN cord-008761-b36x05fn 10 15 the the DT cord-008761-b36x05fn 10 16 interferons interferon NNS cord-008761-b36x05fn 10 17 . . . cord-008761-b36x05fn 11 1 Only only RB cord-008761-b36x05fn 11 2 under under IN cord-008761-b36x05fn 11 3 attack attack NN cord-008761-b36x05fn 11 4 from from IN cord-008761-b36x05fn 11 5 viruses virus NNS cord-008761-b36x05fn 11 6 or or CC cord-008761-b36x05fn 11 7 other other JJ cord-008761-b36x05fn 11 8 forms form NNS cord-008761-b36x05fn 11 9 of of IN cord-008761-b36x05fn 11 10 biological biological JJ cord-008761-b36x05fn 11 11 stress stress NN cord-008761-b36x05fn 11 12 is be VBZ cord-008761-b36x05fn 11 13 the the DT cord-008761-b36x05fn 11 14 interferon interferon NN cord-008761-b36x05fn 11 15 system system NN cord-008761-b36x05fn 11 16 triggered trigger VBD cord-008761-b36x05fn 11 17 . . . cord-008761-b36x05fn 12 1 Hence hence RB cord-008761-b36x05fn 12 2 , , , cord-008761-b36x05fn 12 3 the the DT cord-008761-b36x05fn 12 4 two two CD cord-008761-b36x05fn 12 5 sets set NNS cord-008761-b36x05fn 12 6 of of IN cord-008761-b36x05fn 12 7 fundamental fundamental JJ cord-008761-b36x05fn 12 8 questions question NNS cord-008761-b36x05fn 12 9 which which WDT cord-008761-b36x05fn 12 10 have have VBP cord-008761-b36x05fn 12 11 governed govern VBN cord-008761-b36x05fn 12 12 interferon interferon NN cord-008761-b36x05fn 12 13 research research NN cord-008761-b36x05fn 12 14 : : : cord-008761-b36x05fn 12 15 ( ( -LRB- cord-008761-b36x05fn 12 16 i i NN cord-008761-b36x05fn 12 17 ) ) -RRB- cord-008761-b36x05fn 12 18 the the DT cord-008761-b36x05fn 12 19 physiology physiology NN cord-008761-b36x05fn 12 20 and and CC cord-008761-b36x05fn 12 21 biochemistry biochemistry NN cord-008761-b36x05fn 12 22 of of IN cord-008761-b36x05fn 12 23 induction induction NN cord-008761-b36x05fn 12 24 ( ( -LRB- cord-008761-b36x05fn 12 25 1,2 1,2 CD cord-008761-b36x05fn 12 26 ) ) -RRB- cord-008761-b36x05fn 12 27 and and CC cord-008761-b36x05fn 12 28 ( ( -LRB- cord-008761-b36x05fn 12 29 ii ii NN cord-008761-b36x05fn 12 30 ) ) -RRB- cord-008761-b36x05fn 13 1 the the DT cord-008761-b36x05fn 13 2 physiology physiology NN cord-008761-b36x05fn 13 3 and and CC cord-008761-b36x05fn 13 4 biochemistry biochemistry NN cord-008761-b36x05fn 13 5 of of IN cord-008761-b36x05fn 13 6 action action NN cord-008761-b36x05fn 13 7 ( ( -LRB- cord-008761-b36x05fn 13 8 3 3 CD cord-008761-b36x05fn 13 9 ) ) -RRB- cord-008761-b36x05fn 13 10 . . . cord-008761-b36x05fn 14 1 Possessing possess VBG cord-008761-b36x05fn 14 2 satisfactory satisfactory JJ cord-008761-b36x05fn 14 3 answers answer NNS cord-008761-b36x05fn 14 4 to to IN cord-008761-b36x05fn 14 5 these these DT cord-008761-b36x05fn 14 6 questions question NNS cord-008761-b36x05fn 14 7 is be VBZ cord-008761-b36x05fn 14 8 essential essential JJ cord-008761-b36x05fn 14 9 , , , cord-008761-b36x05fn 14 10 not not RB cord-008761-b36x05fn 14 11 only only RB cord-008761-b36x05fn 14 12 to to TO cord-008761-b36x05fn 14 13 understand understand VB cord-008761-b36x05fn 14 14 the the DT cord-008761-b36x05fn 14 15 natural natural JJ cord-008761-b36x05fn 14 16 role role NN cord-008761-b36x05fn 14 17 of of IN cord-008761-b36x05fn 14 18 the the DT cord-008761-b36x05fn 14 19 interferon interferon NN cord-008761-b36x05fn 14 20 system system NN cord-008761-b36x05fn 14 21 in in IN cord-008761-b36x05fn 14 22 virus virus NN cord-008761-b36x05fn 14 23 disease disease NN cord-008761-b36x05fn 14 24 but but CC cord-008761-b36x05fn 14 25 also also RB cord-008761-b36x05fn 14 26 to to TO cord-008761-b36x05fn 14 27 assess assess VB cord-008761-b36x05fn 14 28 possible possible JJ cord-008761-b36x05fn 14 29 applications application NNS cord-008761-b36x05fn 14 30 in in IN cord-008761-b36x05fn 14 31 medicine medicine NN cord-008761-b36x05fn 14 32 , , , cord-008761-b36x05fn 14 33 in in IN cord-008761-b36x05fn 14 34 particular particular JJ cord-008761-b36x05fn 14 35 the the DT cord-008761-b36x05fn 14 36 use use NN cord-008761-b36x05fn 14 37 of of IN cord-008761-b36x05fn 14 38 interferons interferon NNS cord-008761-b36x05fn 14 39 or or CC cord-008761-b36x05fn 14 40 interferoninducing interferoninduce VBG cord-008761-b36x05fn 14 41 substances substance NNS cord-008761-b36x05fn 14 42 as as IN cord-008761-b36x05fn 14 43 antiviral antiviral JJ cord-008761-b36x05fn 14 44 drugs drug NNS cord-008761-b36x05fn 14 45 . . . cord-008761-b36x05fn 15 1 A a DT cord-008761-b36x05fn 15 2 striking striking JJ cord-008761-b36x05fn 15 3 feature feature NN cord-008761-b36x05fn 15 4 brought bring VBN cord-008761-b36x05fn 15 5 to to IN cord-008761-b36x05fn 15 6 light light NN cord-008761-b36x05fn 15 7 by by IN cord-008761-b36x05fn 15 8 virtually virtually RB cord-008761-b36x05fn 15 9 each each DT cord-008761-b36x05fn 15 10 sector sector NN cord-008761-b36x05fn 15 11 of of IN cord-008761-b36x05fn 15 12 interferon interferon NN cord-008761-b36x05fn 15 13 research research NN cord-008761-b36x05fn 15 14 is be VBZ cord-008761-b36x05fn 15 15 the the DT cord-008761-b36x05fn 15 16 pleomorphism pleomorphism NN cord-008761-b36x05fn 15 17 of of IN cord-008761-b36x05fn 15 18 the the DT cord-008761-b36x05fn 15 19 system system NN cord-008761-b36x05fn 15 20 . . . cord-008761-b36x05fn 16 1 Thus thus RB cord-008761-b36x05fn 16 2 , , , cord-008761-b36x05fn 16 3 each each DT cord-008761-b36x05fn 16 4 animal animal NN cord-008761-b36x05fn 16 5 species species NN cord-008761-b36x05fn 16 6 possesses possess VBZ cord-008761-b36x05fn 16 7 a a DT cord-008761-b36x05fn 16 8 family family NN cord-008761-b36x05fn 16 9 of of IN cord-008761-b36x05fn 16 10 genes gene NNS cord-008761-b36x05fn 16 11 for for IN cord-008761-b36x05fn 16 12 interferon interferon NN cord-008761-b36x05fn 16 13 , , , cord-008761-b36x05fn 16 14 and and CC cord-008761-b36x05fn 16 15 in in IN cord-008761-b36x05fn 16 16 some some DT cord-008761-b36x05fn 16 17 instances instance NNS cord-008761-b36x05fn 16 18 a a DT cord-008761-b36x05fn 16 19 single single JJ cord-008761-b36x05fn 16 20 gene gene NN cord-008761-b36x05fn 16 21 can can MD cord-008761-b36x05fn 16 22 give give VB cord-008761-b36x05fn 16 23 rise rise NN cord-008761-b36x05fn 16 24 to to IN cord-008761-b36x05fn 16 25 mUltiple mUltiple NNP cord-008761-b36x05fn 16 26 molecular molecular JJ cord-008761-b36x05fn 16 27 forms form NNS cord-008761-b36x05fn 16 28 . . . cord-008761-b36x05fn 17 1 Also also RB cord-008761-b36x05fn 17 2 there there EX cord-008761-b36x05fn 17 3 are be VBP cord-008761-b36x05fn 17 4 several several JJ cord-008761-b36x05fn 17 5 ways way NNS cord-008761-b36x05fn 17 6 in in IN cord-008761-b36x05fn 17 7 which which WDT cord-008761-b36x05fn 17 8 production production NN cord-008761-b36x05fn 17 9 of of IN cord-008761-b36x05fn 17 10 these these DT cord-008761-b36x05fn 17 11 interferons interferon NNS cord-008761-b36x05fn 17 12 can can MD cord-008761-b36x05fn 17 13 be be VB cord-008761-b36x05fn 17 14 induced induce VBN cord-008761-b36x05fn 17 15 . . . cord-008761-b36x05fn 18 1 Finally finally RB cord-008761-b36x05fn 18 2 , , , cord-008761-b36x05fn 18 3 the the DT cord-008761-b36x05fn 18 4 antiviral antiviral JJ cord-008761-b36x05fn 18 5 effect effect NN cord-008761-b36x05fn 18 6 is be VBZ cord-008761-b36x05fn 18 7 not not RB cord-008761-b36x05fn 18 8 due due JJ cord-008761-b36x05fn 18 9 to to IN cord-008761-b36x05fn 18 10 a a DT cord-008761-b36x05fn 18 11 single single JJ cord-008761-b36x05fn 18 12 cellular cellular JJ cord-008761-b36x05fn 18 13 modification modification NN cord-008761-b36x05fn 18 14 , , , cord-008761-b36x05fn 18 15 blocking block VBG cord-008761-b36x05fn 18 16 the the DT cord-008761-b36x05fn 18 17 virus virus NN cord-008761-b36x05fn 18 18 at at IN cord-008761-b36x05fn 18 19 one one CD cord-008761-b36x05fn 18 20 particular particular JJ cord-008761-b36x05fn 18 21 junction junction NN cord-008761-b36x05fn 18 22 in in IN cord-008761-b36x05fn 18 23 its -PRON- PRP$ cord-008761-b36x05fn 18 24 replicative replicative JJ cord-008761-b36x05fn 18 25 cycle cycle NN cord-008761-b36x05fn 18 26 . . . cord-008761-b36x05fn 19 1 Rather rather RB cord-008761-b36x05fn 19 2 , , , cord-008761-b36x05fn 19 3 virus virus NN cord-008761-b36x05fn 19 4 replication replication NN cord-008761-b36x05fn 19 5 is be VBZ cord-008761-b36x05fn 19 6 counteracted counteract VBN cord-008761-b36x05fn 19 7 at at IN cord-008761-b36x05fn 19 8 different different JJ cord-008761-b36x05fn 19 9 steps step NNS cord-008761-b36x05fn 19 10 . . . cord-008761-b36x05fn 20 1 Another another DT cord-008761-b36x05fn 20 2 feature feature NN cord-008761-b36x05fn 20 3 worth worth JJ cord-008761-b36x05fn 20 4 mentioning mention VBG cord-008761-b36x05fn 20 5 is be VBZ cord-008761-b36x05fn 20 6 that that IN cord-008761-b36x05fn 20 7 the the DT cord-008761-b36x05fn 20 8 interferon interferon NN cord-008761-b36x05fn 20 9 system system NN cord-008761-b36x05fn 20 10 is be VBZ cord-008761-b36x05fn 20 11 leaky leaky JJ cord-008761-b36x05fn 20 12 blocking blocking NN cord-008761-b36x05fn 20 13 of of IN cord-008761-b36x05fn 20 14 virus virus NN cord-008761-b36x05fn 20 15 replication replication NN cord-008761-b36x05fn 20 16 or or CC cord-008761-b36x05fn 20 17 of of IN cord-008761-b36x05fn 20 18 the the DT cord-008761-b36x05fn 20 19 effects effect NNS cord-008761-b36x05fn 20 20 of of IN cord-008761-b36x05fn 20 21 viruses virus NNS cord-008761-b36x05fn 20 22 on on IN cord-008761-b36x05fn 20 23 the the DT cord-008761-b36x05fn 20 24 host host NN cord-008761-b36x05fn 20 25 is be VBZ cord-008761-b36x05fn 20 26 neither neither CC cord-008761-b36x05fn 20 27 complete complete JJ cord-008761-b36x05fn 20 28 nor nor CC cord-008761-b36x05fn 20 29 permanent permanent JJ cord-008761-b36x05fn 20 30 . . . cord-008761-b36x05fn 21 1 Therefore therefore RB cord-008761-b36x05fn 21 2 , , , cord-008761-b36x05fn 21 3 if if IN cord-008761-b36x05fn 21 4 the the DT cord-008761-b36x05fn 21 5 virus virus NN cord-008761-b36x05fn 21 6 host host NN cord-008761-b36x05fn 21 7 is be VBZ cord-008761-b36x05fn 21 8 placed place VBN cord-008761-b36x05fn 21 9 under under IN cord-008761-b36x05fn 21 10 the the DT cord-008761-b36x05fn 21 11 protective protective JJ cord-008761-b36x05fn 21 12 influence influence NN cord-008761-b36x05fn 21 13 of of IN cord-008761-b36x05fn 21 14 interferon interferon NN cord-008761-b36x05fn 21 15 , , , cord-008761-b36x05fn 21 16 some some DT cord-008761-b36x05fn 21 17 virus virus NN cord-008761-b36x05fn 21 18 replication replication NN cord-008761-b36x05fn 21 19 still still RB cord-008761-b36x05fn 21 20 occurs occur VBZ cord-008761-b36x05fn 21 21 , , , cord-008761-b36x05fn 21 22 and and CC cord-008761-b36x05fn 21 23 as as IN cord-008761-b36x05fn 21 24 the the DT cord-008761-b36x05fn 21 25 interferon interferon NN cord-008761-b36x05fn 21 26 effect effect NN cord-008761-b36x05fn 21 27 wanes wane VBZ cord-008761-b36x05fn 21 28 , , , cord-008761-b36x05fn 21 29 residual residual JJ cord-008761-b36x05fn 21 30 virus virus NN cord-008761-b36x05fn 21 31 can can MD cord-008761-b36x05fn 21 32 again again RB cord-008761-b36x05fn 21 33 multiply multiply VB cord-008761-b36x05fn 21 34 at at IN cord-008761-b36x05fn 21 35 full full JJ cord-008761-b36x05fn 21 36 strength strength NN cord-008761-b36x05fn 21 37 unless unless IN cord-008761-b36x05fn 21 38 this this DT cord-008761-b36x05fn 21 39 would would MD cord-008761-b36x05fn 21 40 be be VB cord-008761-b36x05fn 21 41 blocked block VBN cord-008761-b36x05fn 21 42 by by IN cord-008761-b36x05fn 21 43 some some DT cord-008761-b36x05fn 21 44 other other JJ cord-008761-b36x05fn 21 45 mechanism mechanism NN cord-008761-b36x05fn 21 46 ( ( -LRB- cord-008761-b36x05fn 21 47 e.g. e.g. IN cord-008761-b36x05fn 21 48 specific specific JJ cord-008761-b36x05fn 21 49 immunity immunity NN cord-008761-b36x05fn 21 50 ) ) -RRB- cord-008761-b36x05fn 21 51 which which WDT cord-008761-b36x05fn 21 52 has have VBZ cord-008761-b36x05fn 21 53 been be VBN cord-008761-b36x05fn 21 54 generated generate VBN cord-008761-b36x05fn 21 55 in in IN cord-008761-b36x05fn 21 56 the the DT cord-008761-b36x05fn 21 57 . . . cord-008761-b36x05fn 22 1 meantime meantime RB cord-008761-b36x05fn 22 2 . . . cord-008761-b36x05fn 23 1 Currently currently RB cord-008761-b36x05fn 23 2 , , , cord-008761-b36x05fn 23 3 interferons interferon NNS cord-008761-b36x05fn 23 4 are be VBP cord-008761-b36x05fn 23 5 defined define VBN cord-008761-b36x05fn 23 6 as as IN cord-008761-b36x05fn 23 7 endogenous endogenous JJ cord-008761-b36x05fn 23 8 proteins protein NNS cord-008761-b36x05fn 23 9 which which WDT cord-008761-b36x05fn 23 10 exert exert VBP cord-008761-b36x05fn 23 11 virusnonspecific virusnonspecific NN cord-008761-b36x05fn 23 12 , , , cord-008761-b36x05fn 23 13 antiviral antiviral JJ cord-008761-b36x05fn 23 14 activity activity NN cord-008761-b36x05fn 23 15 at at IN cord-008761-b36x05fn 23 16 least least JJS cord-008761-b36x05fn 23 17 in in IN cord-008761-b36x05fn 23 18 homologous homologous JJ cord-008761-b36x05fn 23 19 cells cell NNS cord-008761-b36x05fn 23 20 through through IN cord-008761-b36x05fn 23 21 cellular cellular JJ cord-008761-b36x05fn 23 22 metabolic metabolic JJ cord-008761-b36x05fn 23 23 processes process NNS cord-008761-b36x05fn 23 24 involving involve VBG cord-008761-b36x05fn 23 25 synthesis synthesis NN cord-008761-b36x05fn 23 26 of of IN cord-008761-b36x05fn 23 27 both both DT cord-008761-b36x05fn 23 28 RNA RNA NNP cord-008761-b36x05fn 23 29 and and CC cord-008761-b36x05fn 23 30 protein protein NN cord-008761-b36x05fn 23 31 ( ( -LRB- cord-008761-b36x05fn 23 32 4 4 CD cord-008761-b36x05fn 23 33 ) ) -RRB- cord-008761-b36x05fn 23 34 . . . cord-008761-b36x05fn 24 1 One one CD cord-008761-b36x05fn 24 2 of of IN cord-008761-b36x05fn 24 3 the the DT cord-008761-b36x05fn 24 4 main main JJ cord-008761-b36x05fn 24 5 points point NNS cord-008761-b36x05fn 24 6 in in IN cord-008761-b36x05fn 24 7 the the DT cord-008761-b36x05fn 24 8 definition definition NN cord-008761-b36x05fn 24 9 is be VBZ cord-008761-b36x05fn 24 10 that that IN cord-008761-b36x05fn 24 11 it -PRON- PRP cord-008761-b36x05fn 24 12 excludes exclude VBZ cord-008761-b36x05fn 24 13 all all DT cord-008761-b36x05fn 24 14 natural natural JJ cord-008761-b36x05fn 24 15 proteinaceous proteinaceous JJ cord-008761-b36x05fn 24 16 factors factor NNS cord-008761-b36x05fn 24 17 which which WDT cord-008761-b36x05fn 24 18 inhibit inhibit VBP cord-008761-b36x05fn 24 19 virus virus NN cord-008761-b36x05fn 24 20 infection infection NN cord-008761-b36x05fn 24 21 at at IN cord-008761-b36x05fn 24 22 extracellular extracellular JJ cord-008761-b36x05fn 24 23 steps step NNS cord-008761-b36x05fn 24 24 , , , cord-008761-b36x05fn 24 25 e.g. e.g. RB cord-008761-b36x05fn 24 26 adsorption adsorption NN cord-008761-b36x05fn 24 27 . . . cord-008761-b36x05fn 25 1 A a DT cord-008761-b36x05fn 25 2 limitation limitation NN cord-008761-b36x05fn 25 3 of of IN cord-008761-b36x05fn 25 4 this this DT cord-008761-b36x05fn 25 5 definition definition NN cord-008761-b36x05fn 25 6 is be VBZ cord-008761-b36x05fn 25 7 that that IN cord-008761-b36x05fn 25 8 it -PRON- PRP cord-008761-b36x05fn 25 9 would would MD cord-008761-b36x05fn 25 10 also also RB cord-008761-b36x05fn 25 11 call call VB cord-008761-b36x05fn 25 12 " " `` cord-008761-b36x05fn 25 13 interferon interferon NN cord-008761-b36x05fn 25 14 " " '' cord-008761-b36x05fn 25 15 any any DT cord-008761-b36x05fn 25 16 protein protein NN cord-008761-b36x05fn 25 17 produced produce VBN cord-008761-b36x05fn 25 18 by by IN cord-008761-b36x05fn 25 19 cells cell NNS cord-008761-b36x05fn 25 20 which which WDT cord-008761-b36x05fn 25 21 induces induce VBZ cord-008761-b36x05fn 25 22 production production NN cord-008761-b36x05fn 25 23 of of IN cord-008761-b36x05fn 25 24 a a DT cord-008761-b36x05fn 25 25 known know VBN cord-008761-b36x05fn 25 26 interferon interferon NN cord-008761-b36x05fn 25 27 . . . cord-008761-b36x05fn 26 1 For for IN cord-008761-b36x05fn 26 2 instance instance NN cord-008761-b36x05fn 26 3 , , , cord-008761-b36x05fn 26 4 a a DT cord-008761-b36x05fn 26 5 monokine monokine NN cord-008761-b36x05fn 26 6 related related JJ cord-008761-b36x05fn 26 7 to to IN cord-008761-b36x05fn 26 8 interleukin interleukin NN cord-008761-b36x05fn 26 9 - - : cord-008761-b36x05fn 26 10 I i NN cord-008761-b36x05fn 26 11 , , , cord-008761-b36x05fn 26 12 has have VBZ cord-008761-b36x05fn 26 13 been be VBN cord-008761-b36x05fn 26 14 shown show VBN cord-008761-b36x05fn 26 15 to to TO cord-008761-b36x05fn 26 16 induce induce VB cord-008761-b36x05fn 26 17 production production NN cord-008761-b36x05fn 26 18 of of IN cord-008761-b36x05fn 26 19 interferon interferon NN cord-008761-b36x05fn 26 20 - - HYPH cord-008761-b36x05fn 26 21 B b NN cord-008761-b36x05fn 26 22 by by IN cord-008761-b36x05fn 26 23 cells cell NNS cord-008761-b36x05fn 26 24 and and CC cord-008761-b36x05fn 26 25 thereby thereby RB cord-008761-b36x05fn 26 26 to to TO cord-008761-b36x05fn 26 27 exert exert VB cord-008761-b36x05fn 26 28 an an DT cord-008761-b36x05fn 26 29 antiviral antiviral JJ cord-008761-b36x05fn 26 30 effect effect NN cord-008761-b36x05fn 26 31 . . . cord-008761-b36x05fn 27 1 In in IN cord-008761-b36x05fn 27 2 mammalians mammalians NNP cord-008761-b36x05fn 27 3 three three CD cord-008761-b36x05fn 27 4 ( ( -LRB- cord-008761-b36x05fn 27 5 sero)types sero)types NNP cord-008761-b36x05fn 27 6 of of IN cord-008761-b36x05fn 27 7 interferon interferon NN cord-008761-b36x05fn 27 8 have have VBP cord-008761-b36x05fn 27 9 been be VBN cord-008761-b36x05fn 27 10 described describe VBN cord-008761-b36x05fn 27 11 : : : cord-008761-b36x05fn 27 12 IFN IFN NNP cord-008761-b36x05fn 27 13 - - HYPH cord-008761-b36x05fn 27 14 a a NNP cord-008761-b36x05fn 27 15 , , , cord-008761-b36x05fn 27 16 IFN IFN NNP cord-008761-b36x05fn 27 17 - - HYPH cord-008761-b36x05fn 27 18 B B NNP cord-008761-b36x05fn 27 19 and and CC cord-008761-b36x05fn 27 20 IFN IFN NNP cord-008761-b36x05fn 27 21 - - HYPH cord-008761-b36x05fn 27 22 y y NNP cord-008761-b36x05fn 27 23 . . . cord-008761-b36x05fn 28 1 Subtypes subtype NNS cord-008761-b36x05fn 28 2 , , , cord-008761-b36x05fn 28 3 reflecting reflect VBG cord-008761-b36x05fn 28 4 the the DT cord-008761-b36x05fn 28 5 presence presence NN cord-008761-b36x05fn 28 6 of of IN cord-008761-b36x05fn 28 7 multiple multiple JJ cord-008761-b36x05fn 28 8 , , , cord-008761-b36x05fn 28 9 slightly slightly RB cord-008761-b36x05fn 28 10 different different JJ cord-008761-b36x05fn 28 11 genes gene NNS cord-008761-b36x05fn 28 12 , , , cord-008761-b36x05fn 28 13 may may MD cord-008761-b36x05fn 28 14 occur occur VB cord-008761-b36x05fn 28 15 . . . cord-008761-b36x05fn 29 1 Thus thus RB cord-008761-b36x05fn 29 2 , , , cord-008761-b36x05fn 29 3 in in IN cord-008761-b36x05fn 29 4 man man NN cord-008761-b36x05fn 29 5 there there EX cord-008761-b36x05fn 29 6 are be VBP cord-008761-b36x05fn 29 7 several several JJ cord-008761-b36x05fn 29 8 subtypes subtype NNS cord-008761-b36x05fn 29 9 of of IN cord-008761-b36x05fn 29 10 IFN IFN NNP cord-008761-b36x05fn 29 11 - - HYPH cord-008761-b36x05fn 29 12 a a DT cord-008761-b36x05fn 30 1 ( ( -LRB- cord-008761-b36x05fn 30 2 HuIFN HuIFN NNP cord-008761-b36x05fn 30 3 - - HYPH cord-008761-b36x05fn 30 4 al al NNP cord-008761-b36x05fn 30 5 , , , cord-008761-b36x05fn 31 1 -a2 -a2 NNP cord-008761-b36x05fn 31 2 , , , cord-008761-b36x05fn 31 3 -a3 -a3 NNP cord-008761-b36x05fn 31 4 , , , cord-008761-b36x05fn 31 5 • • NNP cord-008761-b36x05fn 31 6 .. .. NFP cord-008761-b36x05fn 31 7 ) ) -RRB- cord-008761-b36x05fn 32 1 , , , cord-008761-b36x05fn 32 2 but but CC cord-008761-b36x05fn 32 3 only only RB cord-008761-b36x05fn 32 4 one one CD cord-008761-b36x05fn 32 5 IFN IFN NNP cord-008761-b36x05fn 32 6 - - HYPH cord-008761-b36x05fn 32 7 B B NNP cord-008761-b36x05fn 32 8 and and CC cord-008761-b36x05fn 32 9 -yo -yo VBZ cord-008761-b36x05fn 32 10 Types type NNS cord-008761-b36x05fn 32 11 of of IN cord-008761-b36x05fn 32 12 interferon interferon NN cord-008761-b36x05fn 32 13 ( ( -LRB- cord-008761-b36x05fn 32 14 a a DT cord-008761-b36x05fn 32 15 , , , cord-008761-b36x05fn 32 16 Band Band NNP cord-008761-b36x05fn 32 17 y y NNP cord-008761-b36x05fn 32 18 ) ) -RRB- cord-008761-b36x05fn 32 19 are be VBP cord-008761-b36x05fn 32 20 distinguished distinguish VBN cord-008761-b36x05fn 32 21 on on IN cord-008761-b36x05fn 32 22 the the DT cord-008761-b36x05fn 32 23 basis basis NN cord-008761-b36x05fn 32 24 of of IN cord-008761-b36x05fn 32 25 reactivity reactivity NN cord-008761-b36x05fn 32 26 with with IN cord-008761-b36x05fn 32 27 polyclonal polyclonal JJ cord-008761-b36x05fn 32 28 antisera antisera NN cord-008761-b36x05fn 32 29 . . . cord-008761-b36x05fn 33 1 Antiserum Antiserum NNP cord-008761-b36x05fn 33 2 against against IN cord-008761-b36x05fn 33 3 a a DT cord-008761-b36x05fn 33 4 given give VBN cord-008761-b36x05fn 33 5 type type NN cord-008761-b36x05fn 33 6 neutralizes neutralize VBZ cord-008761-b36x05fn 33 7 biological biological JJ cord-008761-b36x05fn 33 8 activity activity NN cord-008761-b36x05fn 33 9 of of IN cord-008761-b36x05fn 33 10 all all PDT cord-008761-b36x05fn 33 11 its -PRON- PRP$ cord-008761-b36x05fn 33 12 sUbtypes subtype NNS cord-008761-b36x05fn 33 13 but but CC cord-008761-b36x05fn 33 14 does do VBZ cord-008761-b36x05fn 33 15 not not RB cord-008761-b36x05fn 33 16 react react VB cord-008761-b36x05fn 33 17 with with IN cord-008761-b36x05fn 33 18 the the DT cord-008761-b36x05fn 33 19 other other JJ cord-008761-b36x05fn 33 20 types type NNS cord-008761-b36x05fn 33 21 . . . cord-008761-b36x05fn 34 1 Antigenic antigenic JJ cord-008761-b36x05fn 34 2 differences difference NNS cord-008761-b36x05fn 34 3 between between IN cord-008761-b36x05fn 34 4 the the DT cord-008761-b36x05fn 34 5 types type NNS cord-008761-b36x05fn 34 6 reflect reflect VBP cord-008761-b36x05fn 34 7 differences difference NNS cord-008761-b36x05fn 34 8 in in IN cord-008761-b36x05fn 34 9 primary primary JJ cord-008761-b36x05fn 34 10 structures structure NNS cord-008761-b36x05fn 34 11 . . . cord-008761-b36x05fn 35 1 However however RB cord-008761-b36x05fn 35 2 , , , cord-008761-b36x05fn 35 3 some some DT cord-008761-b36x05fn 35 4 homology homology NN cord-008761-b36x05fn 35 5 in in IN cord-008761-b36x05fn 35 6 sequence sequence NN cord-008761-b36x05fn 35 7 exists exist VBZ cord-008761-b36x05fn 35 8 between between IN cord-008761-b36x05fn 35 9 IFN IFN NNP cord-008761-b36x05fn 35 10 - - HYPH cord-008761-b36x05fn 35 11 a a NNP cord-008761-b36x05fn 35 12 and and CC cord-008761-b36x05fn 35 13 IFN IFN NNP cord-008761-b36x05fn 35 14 - - HYPH cord-008761-b36x05fn 35 15 B. B. NNP cord-008761-b36x05fn 36 1 On on IN cord-008761-b36x05fn 36 2 the the DT cord-008761-b36x05fn 36 3 other other JJ cord-008761-b36x05fn 36 4 hand hand NN cord-008761-b36x05fn 36 5 , , , cord-008761-b36x05fn 36 6 the the DT cord-008761-b36x05fn 36 7 eequence eequence NN cord-008761-b36x05fn 36 8 of of IN cord-008761-b36x05fn 36 9 IFN IFN NNP cord-008761-b36x05fn 36 10 - - HYPH cord-008761-b36x05fn 36 11 y y NNP cord-008761-b36x05fn 36 12 is be VBZ cord-008761-b36x05fn 36 13 completely completely RB cord-008761-b36x05fn 36 14 different different JJ cord-008761-b36x05fn 36 15 from from IN cord-008761-b36x05fn 36 16 that that DT cord-008761-b36x05fn 36 17 of of IN cord-008761-b36x05fn 36 18 either either CC cord-008761-b36x05fn 36 19 IFN IFN NNP cord-008761-b36x05fn 36 20 - - HYPH cord-008761-b36x05fn 36 21 a a NN cord-008761-b36x05fn 36 22 or or CC cord-008761-b36x05fn 37 1 -B. -B. . cord-008761-b36x05fn 38 1 The the DT cord-008761-b36x05fn 38 2 structural structural JJ cord-008761-b36x05fn 38 3 similarities similarity NNS cord-008761-b36x05fn 38 4 and and CC cord-008761-b36x05fn 38 5 differences difference NNS cord-008761-b36x05fn 38 6 between between IN cord-008761-b36x05fn 38 7 the the DT cord-008761-b36x05fn 38 8 IFN IFN NNP cord-008761-b36x05fn 38 9 types type NNS cord-008761-b36x05fn 38 10 are be VBP cord-008761-b36x05fn 38 11 reflected reflect VBN cord-008761-b36x05fn 38 12 by by IN cord-008761-b36x05fn 38 13 the the DT cord-008761-b36x05fn 38 14 fact fact NN cord-008761-b36x05fn 38 15 that that IN cord-008761-b36x05fn 38 16 IFN IFN NNP cord-008761-b36x05fn 38 17 - - HYPH cord-008761-b36x05fn 38 18 a a NNP cord-008761-b36x05fn 38 19 and and CC cord-008761-b36x05fn 38 20 -B -b ADD cord-008761-b36x05fn 38 21 , , , cord-008761-b36x05fn 38 22 in in IN cord-008761-b36x05fn 38 23 acting act VBG cord-008761-b36x05fn 38 24 on on IN cord-008761-b36x05fn 38 25 cells cell NNS cord-008761-b36x05fn 38 26 , , , cord-008761-b36x05fn 38 27 share share VBP cord-008761-b36x05fn 38 28 a a DT cord-008761-b36x05fn 38 29 common common JJ cord-008761-b36x05fn 38 30 membrane membrane NN cord-008761-b36x05fn 38 31 receptor receptor NN cord-008761-b36x05fn 38 32 , , , cord-008761-b36x05fn 38 33 while while IN cord-008761-b36x05fn 38 34 IFN IFN NNP cord-008761-b36x05fn 38 35 - - HYPH cord-008761-b36x05fn 38 36 y y NNP cord-008761-b36x05fn 38 37 uses use VBZ cord-008761-b36x05fn 38 38 a a DT cord-008761-b36x05fn 38 39 different different JJ cord-008761-b36x05fn 38 40 receptor receptor NN cord-008761-b36x05fn 38 41 ( ( -LRB- cord-008761-b36x05fn 38 42 5 5 CD cord-008761-b36x05fn 38 43 ) ) -RRB- cord-008761-b36x05fn 38 44 . . . cord-008761-b36x05fn 39 1 Interferons interferon NNS cord-008761-b36x05fn 39 2 for for IN cord-008761-b36x05fn 39 3 animal animal NN cord-008761-b36x05fn 39 4 experiments experiment NNS cord-008761-b36x05fn 39 5 or or CC cord-008761-b36x05fn 39 6 for for IN cord-008761-b36x05fn 39 7 clinical clinical JJ cord-008761-b36x05fn 39 8 trials trial NNS cord-008761-b36x05fn 39 9 are be VBP cord-008761-b36x05fn 39 10 prepared prepare VBN cord-008761-b36x05fn 39 11 in in IN cord-008761-b36x05fn 39 12 various various JJ cord-008761-b36x05fn 39 13 ways way NNS cord-008761-b36x05fn 39 14 . . . cord-008761-b36x05fn 40 1 At at IN cord-008761-b36x05fn 40 2 present present NN cord-008761-b36x05fn 40 3 it -PRON- PRP cord-008761-b36x05fn 40 4 is be VBZ cord-008761-b36x05fn 40 5 common common JJ cord-008761-b36x05fn 40 6 and and CC cord-008761-b36x05fn 40 7 useful useful JJ cord-008761-b36x05fn 40 8 to to TO cord-008761-b36x05fn 40 9 make make VB cord-008761-b36x05fn 40 10 a a DT cord-008761-b36x05fn 40 11 distinction distinction NN cord-008761-b36x05fn 40 12 between between IN cord-008761-b36x05fn 40 13 preparations preparation NNS cord-008761-b36x05fn 40 14 of of IN cord-008761-b36x05fn 40 15 so so RB cord-008761-b36x05fn 40 16 - - HYPH cord-008761-b36x05fn 40 17 called call VBN cord-008761-b36x05fn 40 18 natural natural JJ cord-008761-b36x05fn 40 19 interferons interferon NNS cord-008761-b36x05fn 40 20 and and CC cord-008761-b36x05fn 40 21 preparations preparation NNS cord-008761-b36x05fn 40 22 of of IN cord-008761-b36x05fn 40 23 recombinant recombinant JJ cord-008761-b36x05fn 40 24 DNA dna NN cord-008761-b36x05fn 40 25 - - HYPH cord-008761-b36x05fn 40 26 derived derive VBN cord-008761-b36x05fn 40 27 interferon interferon NN cord-008761-b36x05fn 40 28 ( ( -LRB- cord-008761-b36x05fn 40 29 rDd rDd NNS cord-008761-b36x05fn 40 30 - - , cord-008761-b36x05fn 40 31 interferons interferon NNS cord-008761-b36x05fn 40 32 ) ) -RRB- cord-008761-b36x05fn 40 33 . . . cord-008761-b36x05fn 41 1 Among among IN cord-008761-b36x05fn 41 2 the the DT cord-008761-b36x05fn 41 3 natural natural JJ cord-008761-b36x05fn 41 4 interferon interferon NN cord-008761-b36x05fn 41 5 preparations preparation NNS cord-008761-b36x05fn 41 6 , , , cord-008761-b36x05fn 41 7 those those DT cord-008761-b36x05fn 41 8 most most RBS cord-008761-b36x05fn 41 9 commonly commonly RB cord-008761-b36x05fn 41 10 used use VBN cord-008761-b36x05fn 41 11 are be VBP cord-008761-b36x05fn 41 12 as as IN cord-008761-b36x05fn 41 13 follows follow VBZ cord-008761-b36x05fn 41 14 . . . cord-008761-b36x05fn 42 1 Interferon interferon NN cord-008761-b36x05fn 42 2 prepared prepare VBD cord-008761-b36x05fn 42 3 from from IN cord-008761-b36x05fn 42 4 mouse mouse NN cord-008761-b36x05fn 42 5 cell cell NN cord-008761-b36x05fn 42 6 lines line NNS cord-008761-b36x05fn 42 7 infected infect VBN cord-008761-b36x05fn 42 8 with with IN cord-008761-b36x05fn 42 9 Newcastle Newcastle NNP cord-008761-b36x05fn 42 10 disease disease NN cord-008761-b36x05fn 42 11 virus virus NN cord-008761-b36x05fn 42 12 is be VBZ cord-008761-b36x05fn 42 13 a a DT cord-008761-b36x05fn 42 14 mixture mixture NN cord-008761-b36x05fn 42 15 of of IN cord-008761-b36x05fn 42 16 a a DT cord-008761-b36x05fn 42 17 and and CC cord-008761-b36x05fn 42 18 B b NN cord-008761-b36x05fn 42 19 ( ( -LRB- cord-008761-b36x05fn 42 20 6 6 CD cord-008761-b36x05fn 42 21 ) ) -RRB- cord-008761-b36x05fn 42 22 . . . cord-008761-b36x05fn 43 1 The the DT cord-008761-b36x05fn 43 2 two two CD cord-008761-b36x05fn 43 3 types type NNS cord-008761-b36x05fn 43 4 can can MD cord-008761-b36x05fn 43 5 be be VB cord-008761-b36x05fn 43 6 separated separate VBN cord-008761-b36x05fn 43 7 but but CC cord-008761-b36x05fn 43 8 this this DT cord-008761-b36x05fn 43 9 has have VBZ cord-008761-b36x05fn 43 10 seldomly seldomly RB cord-008761-b36x05fn 43 11 if if IN cord-008761-b36x05fn 43 12 ever ever RB cord-008761-b36x05fn 43 13 been be VBN cord-008761-b36x05fn 43 14 done do VBN cord-008761-b36x05fn 43 15 for for IN cord-008761-b36x05fn 43 16 preparations preparation NNS cord-008761-b36x05fn 43 17 destined destine VBN cord-008761-b36x05fn 43 18 to to TO cord-008761-b36x05fn 43 19 perform perform VB cord-008761-b36x05fn 43 20 in in IN cord-008761-b36x05fn 43 21 vivo vivo NN cord-008761-b36x05fn 43 22 experiments experiment NNS cord-008761-b36x05fn 43 23 . . . cord-008761-b36x05fn 44 1 Thus thus RB cord-008761-b36x05fn 44 2 , , , cord-008761-b36x05fn 44 3 literature literature NN cord-008761-b36x05fn 44 4 data datum NNS cord-008761-b36x05fn 44 5 are be VBP cord-008761-b36x05fn 44 6 representative representative JJ cord-008761-b36x05fn 44 7 for for IN cord-008761-b36x05fn 44 8 a a DT cord-008761-b36x05fn 44 9 mixture mixture NN cord-008761-b36x05fn 44 10 of of IN cord-008761-b36x05fn 44 11 IFN IFN NNP cord-008761-b36x05fn 44 12 - - HYPH cord-008761-b36x05fn 44 13 a a NN cord-008761-b36x05fn 44 14 and and CC cord-008761-b36x05fn 44 15 -B. -b. ADD cord-008761-b36x05fn 45 1 Interferon interferon NN cord-008761-b36x05fn 45 2 prepared prepare VBD cord-008761-b36x05fn 45 3 from from IN cord-008761-b36x05fn 45 4 suspensions suspension NNS cord-008761-b36x05fn 45 5 of of IN cord-008761-b36x05fn 45 6 mouse mouse NN cord-008761-b36x05fn 45 7 splenocytes splenocytes NNP cord-008761-b36x05fn 45 8 incubated incubate VBN cord-008761-b36x05fn 45 9 in in IN cord-008761-b36x05fn 45 10 the the DT cord-008761-b36x05fn 45 11 presence presence NN cord-008761-b36x05fn 45 12 of of IN cord-008761-b36x05fn 45 13 lymphocyte lymphocyte NN cord-008761-b36x05fn 45 14 mitogens mitogens NNP cord-008761-b36x05fn 45 15 ( ( -LRB- cord-008761-b36x05fn 45 16 concanavalin concanavalin NNP cord-008761-b36x05fn 45 17 A A NNP cord-008761-b36x05fn 45 18 , , , cord-008761-b36x05fn 45 19 phytohemagglutinine phytohemagglutinine NN cord-008761-b36x05fn 45 20 , , , cord-008761-b36x05fn 45 21 Staphylococcus Staphylococcus NNP cord-008761-b36x05fn 45 22 enterotoxin enterotoxin NNP cord-008761-b36x05fn 45 23 , , , cord-008761-b36x05fn 45 24 .. .. NFP cord-008761-b36x05fn 45 25 • • NNP cord-008761-b36x05fn 45 26 ) ) -RRB- cord-008761-b36x05fn 45 27 contain contain VBP cord-008761-b36x05fn 45 28 IFN IFN NNP cord-008761-b36x05fn 45 29 - - HYPH cord-008761-b36x05fn 45 30 y y NNP cord-008761-b36x05fn 45 31 . . . cord-008761-b36x05fn 46 1 It -PRON- PRP cord-008761-b36x05fn 46 2 should should MD cord-008761-b36x05fn 46 3 be be VB cord-008761-b36x05fn 46 4 mentioned mention VBN cord-008761-b36x05fn 46 5 that that IN cord-008761-b36x05fn 46 6 , , , cord-008761-b36x05fn 46 7 depending depend VBG cord-008761-b36x05fn 46 8 on on IN cord-008761-b36x05fn 46 9 the the DT cord-008761-b36x05fn 46 10 degree degree NN cord-008761-b36x05fn 46 11 of of IN cord-008761-b36x05fn 46 12 purity purity NN cord-008761-b36x05fn 46 13 , , , cord-008761-b36x05fn 46 14 these these DT cord-008761-b36x05fn 46 15 preparations preparation NNS cord-008761-b36x05fn 46 16 also also RB cord-008761-b36x05fn 46 17 contain contain VBP cord-008761-b36x05fn 46 18 variable variable JJ cord-008761-b36x05fn 46 19 numbers number NNS cord-008761-b36x05fn 46 20 and and CC cord-008761-b36x05fn 46 21 quantities quantity NNS cord-008761-b36x05fn 46 22 of of IN cord-008761-b36x05fn 46 23 monokines monokine NNS cord-008761-b36x05fn 46 24 and and CC cord-008761-b36x05fn 46 25 lymphokines lymphokine NNS cord-008761-b36x05fn 46 26 such such JJ cord-008761-b36x05fn 46 27 as as IN cord-008761-b36x05fn 46 28 interleukins interleukin NNS cord-008761-b36x05fn 46 29 , , , cord-008761-b36x05fn 46 30 colony colony NN cord-008761-b36x05fn 46 31 stimulating stimulating JJ cord-008761-b36x05fn 46 32 factors factor NNS cord-008761-b36x05fn 46 33 , , , cord-008761-b36x05fn 46 34 etc etc FW cord-008761-b36x05fn 46 35 . . . cord-008761-b36x05fn 47 1 Hence hence RB cord-008761-b36x05fn 47 2 , , , cord-008761-b36x05fn 47 3 all all DT cord-008761-b36x05fn 47 4 data datum NNS cord-008761-b36x05fn 47 5 obtained obtain VBN cord-008761-b36x05fn 47 6 so so RB cord-008761-b36x05fn 47 7 far far RB cord-008761-b36x05fn 47 8 with with IN cord-008761-b36x05fn 47 9 these these DT cord-008761-b36x05fn 47 10 preparations preparation NNS cord-008761-b36x05fn 47 11 represent represent VBP cord-008761-b36x05fn 47 12 effects effect NNS cord-008761-b36x05fn 47 13 of of IN cord-008761-b36x05fn 47 14 total total JJ cord-008761-b36x05fn 47 15 lymphokine lymphokine NN cord-008761-b36x05fn 47 16 rather rather RB cord-008761-b36x05fn 47 17 than than IN cord-008761-b36x05fn 47 18 of of IN cord-008761-b36x05fn 47 19 IFN IFN NNP cord-008761-b36x05fn 47 20 - - HYPH cord-008761-b36x05fn 47 21 y y NNP cord-008761-b36x05fn 47 22 preparations preparation NNS cord-008761-b36x05fn 47 23 . . . cord-008761-b36x05fn 48 1 The the DT cord-008761-b36x05fn 48 2 following following JJ cord-008761-b36x05fn 48 3 interferons interferon NNS cord-008761-b36x05fn 48 4 are be VBP cord-008761-b36x05fn 48 5 currently currently RB cord-008761-b36x05fn 48 6 available available JJ cord-008761-b36x05fn 48 7 for for IN cord-008761-b36x05fn 48 8 clinical clinical JJ cord-008761-b36x05fn 48 9 studies study NNS cord-008761-b36x05fn 48 10 in in IN cord-008761-b36x05fn 48 11 Immune Immune NNP cord-008761-b36x05fn 48 12 interferon interferon NN cord-008761-b36x05fn 48 13 is be VBZ cord-008761-b36x05fn 48 14 produced produce VBN cord-008761-b36x05fn 48 15 from from IN cord-008761-b36x05fn 48 16 suspensions suspension NNS cord-008761-b36x05fn 48 17 of of IN cord-008761-b36x05fn 48 18 blood blood NN cord-008761-b36x05fn 48 19 leukocytes leukocyte NNS cord-008761-b36x05fn 48 20 induced induce VBN cord-008761-b36x05fn 48 21 with with IN cord-008761-b36x05fn 48 22 mitogens mitogens NNP cord-008761-b36x05fn 48 23 . . . cord-008761-b36x05fn 49 1 The the DT cord-008761-b36x05fn 49 2 antiviral antiviral JJ cord-008761-b36x05fn 49 3 activity activity NN cord-008761-b36x05fn 49 4 present present JJ cord-008761-b36x05fn 49 5 in in IN cord-008761-b36x05fn 49 6 these these DT cord-008761-b36x05fn 49 7 preparations preparation NNS cord-008761-b36x05fn 49 8 is be VBZ cord-008761-b36x05fn 49 9 mainly mainly RB cord-008761-b36x05fn 49 10 due due JJ cord-008761-b36x05fn 49 11 to to IN cord-008761-b36x05fn 49 12 IFN IFN NNP cord-008761-b36x05fn 49 13 - - HYPH cord-008761-b36x05fn 49 14 y y NNP cord-008761-b36x05fn 49 15 . . . cord-008761-b36x05fn 50 1 Small small JJ cord-008761-b36x05fn 50 2 quantities quantity NNS cord-008761-b36x05fn 50 3 of of IN cord-008761-b36x05fn 50 4 IFN-~ IFN-~ NNP cord-008761-b36x05fn 50 5 and and CC cord-008761-b36x05fn 50 6 -S -S : cord-008761-b36x05fn 50 7 may may MD cord-008761-b36x05fn 50 8 be be VB cord-008761-b36x05fn 50 9 present present JJ cord-008761-b36x05fn 50 10 . . . cord-008761-b36x05fn 51 1 However however RB cord-008761-b36x05fn 51 2 , , , cord-008761-b36x05fn 51 3 the the DT cord-008761-b36x05fn 51 4 main main JJ cord-008761-b36x05fn 51 5 contaminants contaminant NNS cord-008761-b36x05fn 51 6 are be VBP cord-008761-b36x05fn 51 7 several several JJ cord-008761-b36x05fn 51 8 lymphokines lymphokine NNS cord-008761-b36x05fn 51 9 , , , cord-008761-b36x05fn 51 10 some some DT cord-008761-b36x05fn 51 11 of of IN cord-008761-b36x05fn 51 12 which which WDT cord-008761-b36x05fn 51 13 may may MD cord-008761-b36x05fn 51 14 indirectly indirectly RB cord-008761-b36x05fn 51 15 affect affect VB cord-008761-b36x05fn 51 16 viral viral JJ cord-008761-b36x05fn 51 17 disease disease NN cord-008761-b36x05fn 51 18 , , , cord-008761-b36x05fn 51 19 for for IN cord-008761-b36x05fn 51 20 instance instance NN cord-008761-b36x05fn 51 21 by by IN cord-008761-b36x05fn 51 22 modulating modulate VBG cord-008761-b36x05fn 51 23 the the DT cord-008761-b36x05fn 51 24 immune immune JJ cord-008761-b36x05fn 51 25 system system NN cord-008761-b36x05fn 51 26 . . . cord-008761-b36x05fn 52 1 The the DT cord-008761-b36x05fn 52 2 prototype prototype NN cord-008761-b36x05fn 52 3 of of IN cord-008761-b36x05fn 52 4 rOd rod NN cord-008761-b36x05fn 52 5 - - HYPH cord-008761-b36x05fn 52 6 interferon interferon NN cord-008761-b36x05fn 52 7 is be VBZ cord-008761-b36x05fn 52 8 human human JJ cord-008761-b36x05fn 52 9 IFN IFN NNP cord-008761-b36x05fn 52 10 - - HYPH cord-008761-b36x05fn 52 11 a2 a2 NNP cord-008761-b36x05fn 52 12 prepared prepare VBD cord-008761-b36x05fn 52 13 from from IN cord-008761-b36x05fn 52 14 E.coli E.coli NNS cord-008761-b36x05fn 52 15 or or CC cord-008761-b36x05fn 52 16 yeasts yeast NNS cord-008761-b36x05fn 52 17 containing contain VBG cord-008761-b36x05fn 52 18 an an DT cord-008761-b36x05fn 52 19 adequate adequate JJ cord-008761-b36x05fn 52 20 expression expression NN cord-008761-b36x05fn 52 21 plasmid plasmid NN cord-008761-b36x05fn 52 22 into into IN cord-008761-b36x05fn 52 23 which which WDT cord-008761-b36x05fn 52 24 the the DT cord-008761-b36x05fn 52 25 interferon interferon NN cord-008761-b36x05fn 52 26 genes gene NNS cord-008761-b36x05fn 52 27 have have VBP cord-008761-b36x05fn 52 28 been be VBN cord-008761-b36x05fn 52 29 inserted insert VBN cord-008761-b36x05fn 52 30 ( ( -LRB- cord-008761-b36x05fn 52 31 7 7 CD cord-008761-b36x05fn 52 32 ) ) -RRB- cord-008761-b36x05fn 52 33 . . . cord-008761-b36x05fn 53 1 In in IN cord-008761-b36x05fn 53 2 their -PRON- PRP$ cord-008761-b36x05fn 53 3 crude crude NN cord-008761-b36x05fn 53 4 form form NN cord-008761-b36x05fn 53 5 these these DT cord-008761-b36x05fn 53 6 preparations preparation NNS cord-008761-b36x05fn 53 7 do do VBP cord-008761-b36x05fn 53 8 not not RB cord-008761-b36x05fn 53 9 contain contain VB cord-008761-b36x05fn 53 10 any any DT cord-008761-b36x05fn 53 11 products product NNS cord-008761-b36x05fn 53 12 of of IN cord-008761-b36x05fn 53 13 human human JJ cord-008761-b36x05fn 53 14 origin origin NN cord-008761-b36x05fn 53 15 other other JJ cord-008761-b36x05fn 53 16 than than IN cord-008761-b36x05fn 53 17 the the DT cord-008761-b36x05fn 53 18 interferons interferon NNS cord-008761-b36x05fn 53 19 . . . cord-008761-b36x05fn 54 1 Bacterial bacterial JJ cord-008761-b36x05fn 54 2 products product NNS cord-008761-b36x05fn 54 3 are be VBP cord-008761-b36x05fn 54 4 completely completely RB cord-008761-b36x05fn 54 5 removed remove VBN cord-008761-b36x05fn 54 6 by by IN cord-008761-b36x05fn 54 7 the the DT cord-008761-b36x05fn 54 8 purification purification NN cord-008761-b36x05fn 54 9 process process NN cord-008761-b36x05fn 54 10 . . . cord-008761-b36x05fn 55 1 The the DT cord-008761-b36x05fn 55 2 main main JJ cord-008761-b36x05fn 55 3 difference difference NN cord-008761-b36x05fn 55 4 between between IN cord-008761-b36x05fn 55 5 these these DT cord-008761-b36x05fn 55 6 products product NNS cord-008761-b36x05fn 55 7 and and CC cord-008761-b36x05fn 55 8 their -PRON- PRP$ cord-008761-b36x05fn 55 9 natural natural JJ cord-008761-b36x05fn 55 10 - - HYPH cord-008761-b36x05fn 55 11 source source NN cord-008761-b36x05fn 55 12 - - HYPH cord-008761-b36x05fn 55 13 derived derive VBN cord-008761-b36x05fn 55 14 counterparts counterpart NNS cord-008761-b36x05fn 55 15 is be VBZ cord-008761-b36x05fn 55 16 that that IN cord-008761-b36x05fn 55 17 they -PRON- PRP cord-008761-b36x05fn 55 18 contain contain VBP cord-008761-b36x05fn 55 19 only only RB cord-008761-b36x05fn 55 20 a a DT cord-008761-b36x05fn 55 21 single single JJ cord-008761-b36x05fn 55 22 subtype subtype NN cord-008761-b36x05fn 55 23 , , , cord-008761-b36x05fn 55 24 namely namely RB cord-008761-b36x05fn 55 25 a2 a2 NNP cord-008761-b36x05fn 55 26 ' ' '' cord-008761-b36x05fn 55 27 While while IN cord-008761-b36x05fn 55 28 it -PRON- PRP cord-008761-b36x05fn 55 29 is be VBZ cord-008761-b36x05fn 55 30 known know VBN cord-008761-b36x05fn 55 31 that that IN cord-008761-b36x05fn 55 32 different different JJ cord-008761-b36x05fn 55 33 subtypes subtype NNS cord-008761-b36x05fn 55 34 of of IN cord-008761-b36x05fn 55 35 HuIFN-~ huifn-~ CD cord-008761-b36x05fn 55 36 may may MD cord-008761-b36x05fn 55 37 differ differ VB cord-008761-b36x05fn 55 38 in in IN cord-008761-b36x05fn 55 39 their -PRON- PRP$ cord-008761-b36x05fn 55 40 antiviral antiviral JJ cord-008761-b36x05fn 55 41 potency potency NN cord-008761-b36x05fn 55 42 depending depend VBG cord-008761-b36x05fn 55 43 on on IN cord-008761-b36x05fn 55 44 the the DT cord-008761-b36x05fn 55 45 cells cell NNS cord-008761-b36x05fn 55 46 on on IN cord-008761-b36x05fn 55 47 which which WDT cord-008761-b36x05fn 55 48 they -PRON- PRP cord-008761-b36x05fn 55 49 are be VBP cord-008761-b36x05fn 55 50 tested test VBN cord-008761-b36x05fn 55 51 , , , cord-008761-b36x05fn 55 52 it -PRON- PRP cord-008761-b36x05fn 55 53 is be VBZ cord-008761-b36x05fn 55 54 not not RB cord-008761-b36x05fn 55 55 yet yet RB cord-008761-b36x05fn 55 56 known know VBN cord-008761-b36x05fn 55 57 whether whether IN cord-008761-b36x05fn 55 58 this this DT cord-008761-b36x05fn 55 59 has have VBZ cord-008761-b36x05fn 55 60 any any DT cord-008761-b36x05fn 55 61 repercussion repercussion NN cord-008761-b36x05fn 55 62 for for IN cord-008761-b36x05fn 55 63 the the DT cord-008761-b36x05fn 55 64 clinical clinical JJ cord-008761-b36x05fn 55 65 effects effect NNS cord-008761-b36x05fn 55 66 . . . cord-008761-b36x05fn 56 1 Another another DT cord-008761-b36x05fn 56 2 currently currently RB cord-008761-b36x05fn 56 3 available available JJ cord-008761-b36x05fn 56 4 rOd rod NN cord-008761-b36x05fn 56 5 - - HYPH cord-008761-b36x05fn 56 6 interferon interferon NN cord-008761-b36x05fn 56 7 is be VBZ cord-008761-b36x05fn 56 8 HuIFN-~ HuIFN-~ NNP cord-008761-b36x05fn 56 9 produced produce VBN cord-008761-b36x05fn 56 10 in in IN cord-008761-b36x05fn 56 11 E.coli E.coli NNS cord-008761-b36x05fn 56 12 . . . cord-008761-b36x05fn 57 1 This this DT cord-008761-b36x05fn 57 2 interferon interferon NN cord-008761-b36x05fn 57 3 differs differ VBZ cord-008761-b36x05fn 57 4 from from IN cord-008761-b36x05fn 57 5 the the DT cord-008761-b36x05fn 57 6 natural natural JJ cord-008761-b36x05fn 57 7 counterpart counterpart NN cord-008761-b36x05fn 57 8 by by IN cord-008761-b36x05fn 57 9 the the DT cord-008761-b36x05fn 57 10 absence absence NN cord-008761-b36x05fn 57 11 of of IN cord-008761-b36x05fn 57 12 carbohydrate carbohydrate NN cord-008761-b36x05fn 57 13 side side NN cord-008761-b36x05fn 57 14 - - HYPH cord-008761-b36x05fn 57 15 chains chain NNS cord-008761-b36x05fn 57 16 . . . cord-008761-b36x05fn 58 1 Although although IN cord-008761-b36x05fn 58 2 these these DT cord-008761-b36x05fn 58 3 side side NN cord-008761-b36x05fn 58 4 - - HYPH cord-008761-b36x05fn 58 5 chains chain NNS cord-008761-b36x05fn 58 6 do do VBP cord-008761-b36x05fn 58 7 not not RB cord-008761-b36x05fn 58 8 playa playa VB cord-008761-b36x05fn 58 9 significant significant JJ cord-008761-b36x05fn 58 10 role role NN cord-008761-b36x05fn 58 11 in in IN cord-008761-b36x05fn 58 12 the the DT cord-008761-b36x05fn 58 13 effects effect NNS cord-008761-b36x05fn 58 14 of of IN cord-008761-b36x05fn 58 15 the the DT cord-008761-b36x05fn 58 16 IFN IFN NNP cord-008761-b36x05fn 58 17 - - HYPH cord-008761-b36x05fn 58 18 S S NNP cord-008761-b36x05fn 58 19 on on IN cord-008761-b36x05fn 58 20 cells cell NNS cord-008761-b36x05fn 58 21 , , , cord-008761-b36x05fn 58 22 the the DT cord-008761-b36x05fn 58 23 pharmacokinetic pharmacokinetic JJ cord-008761-b36x05fn 58 24 behavior behavior NN cord-008761-b36x05fn 58 25 of of IN cord-008761-b36x05fn 58 26 this this DT cord-008761-b36x05fn 58 27 rDd rDd NNS cord-008761-b36x05fn 58 28 - - HYPH cord-008761-b36x05fn 58 29 IFN IFN NNP cord-008761-b36x05fn 58 30 - - HYPH cord-008761-b36x05fn 58 31 S S NNP cord-008761-b36x05fn 58 32 was be VBD cord-008761-b36x05fn 58 33 found find VBN cord-008761-b36x05fn 58 34 to to TO cord-008761-b36x05fn 58 35 be be VB cord-008761-b36x05fn 58 36 rather rather RB cord-008761-b36x05fn 58 37 different different JJ cord-008761-b36x05fn 58 38 from from IN cord-008761-b36x05fn 58 39 that that DT cord-008761-b36x05fn 58 40 of of IN cord-008761-b36x05fn 58 41 natural natural JJ cord-008761-b36x05fn 58 42 fibroblast fibroblast NN cord-008761-b36x05fn 58 43 - - HYPH cord-008761-b36x05fn 58 44 derived derive VBN cord-008761-b36x05fn 58 45 interferon interferon NN cord-008761-b36x05fn 59 1 ( ( -LRB- cord-008761-b36x05fn 59 2 8) 8) NNP cord-008761-b36x05fn 59 3 . . . cord-008761-b36x05fn 60 1 rDd rDd NNPS cord-008761-b36x05fn 60 2 - - HYPH cord-008761-b36x05fn 60 3 HuIFN HuIFN NNP cord-008761-b36x05fn 60 4 - - HYPH cord-008761-b36x05fn 60 5 S s NN cord-008761-b36x05fn 60 6 possessing possess VBG cord-008761-b36x05fn 60 7 carbohydrate carbohydrate NN cord-008761-b36x05fn 60 8 side side NN cord-008761-b36x05fn 60 9 - - HYPH cord-008761-b36x05fn 60 10 chains chain NNS cord-008761-b36x05fn 60 11 can can MD cord-008761-b36x05fn 60 12 be be VB cord-008761-b36x05fn 60 13 obtained obtain VBN cord-008761-b36x05fn 60 14 by by IN cord-008761-b36x05fn 60 15 insertion insertion NN cord-008761-b36x05fn 60 16 and and CC cord-008761-b36x05fn 60 17 expression expression NN cord-008761-b36x05fn 60 18 of of IN cord-008761-b36x05fn 60 19 the the DT cord-008761-b36x05fn 60 20 gene gene NN cord-008761-b36x05fn 60 21 in in IN cord-008761-b36x05fn 60 22 yeasts yeast NNS cord-008761-b36x05fn 60 23 or or CC cord-008761-b36x05fn 60 24 mammalian mammalian JJ cord-008761-b36x05fn 60 25 cells cell NNS cord-008761-b36x05fn 60 26 . . . cord-008761-b36x05fn 61 1 Finally finally RB cord-008761-b36x05fn 61 2 , , , cord-008761-b36x05fn 61 3 a a DT cord-008761-b36x05fn 61 4 rDd rDd NNS cord-008761-b36x05fn 61 5 - - HYPH cord-008761-b36x05fn 61 6 HuIFN HuIFN NNP cord-008761-b36x05fn 61 7 - - HYPH cord-008761-b36x05fn 61 8 y y NNP cord-008761-b36x05fn 61 9 is be VBZ cord-008761-b36x05fn 61 10 available available JJ cord-008761-b36x05fn 61 11 , , , cord-008761-b36x05fn 61 12 which which WDT cord-008761-b36x05fn 61 13 is be VBZ cord-008761-b36x05fn 61 14 produced produce VBN cord-008761-b36x05fn 61 15 from from IN cord-008761-b36x05fn 61 16 E.coli E.coli NNS cord-008761-b36x05fn 61 17 or or CC cord-008761-b36x05fn 61 18 mammlian mammlian JJ cord-008761-b36x05fn 61 19 expression expression NN cord-008761-b36x05fn 61 20 systems system NNS cord-008761-b36x05fn 61 21 . . . cord-008761-b36x05fn 62 1 rDd rDd NNS cord-008761-b36x05fn 62 2 - - : cord-008761-b36x05fn 62 3 Interferons interferon NNS cord-008761-b36x05fn 62 4 for for IN cord-008761-b36x05fn 62 5 experiments experiment NNS cord-008761-b36x05fn 62 6 in in IN cord-008761-b36x05fn 62 7 animals animal NNS cord-008761-b36x05fn 62 8 are be VBP cord-008761-b36x05fn 62 9 becoming become VBG cord-008761-b36x05fn 62 10 available available JJ cord-008761-b36x05fn 62 11 at at IN cord-008761-b36x05fn 62 12 a a DT cord-008761-b36x05fn 62 13 much much RB cord-008761-b36x05fn 62 14 slower slow JJR cord-008761-b36x05fn 62 15 pace pace NN cord-008761-b36x05fn 62 16 and and CC cord-008761-b36x05fn 62 17 in in IN cord-008761-b36x05fn 62 18 lesser less JJR cord-008761-b36x05fn 62 19 quantities quantity NNS cord-008761-b36x05fn 62 20 than than IN cord-008761-b36x05fn 62 21 those those DT cord-008761-b36x05fn 62 22 necessary necessary JJ cord-008761-b36x05fn 62 23 for for IN cord-008761-b36x05fn 62 24 experiments experiment NNS cord-008761-b36x05fn 62 25 in in IN cord-008761-b36x05fn 62 26 man man NN cord-008761-b36x05fn 62 27 . . . cord-008761-b36x05fn 63 1 The the DT cord-008761-b36x05fn 63 2 genes gene NNS cord-008761-b36x05fn 63 3 for for IN cord-008761-b36x05fn 63 4 several several JJ cord-008761-b36x05fn 63 5 animal animal NN cord-008761-b36x05fn 63 6 interferons interferon NNS cord-008761-b36x05fn 63 7 have have VBP cord-008761-b36x05fn 63 8 been be VBN cord-008761-b36x05fn 63 9 isolated isolate VBN cord-008761-b36x05fn 63 10 and and CC cord-008761-b36x05fn 63 11 brought bring VBN cord-008761-b36x05fn 63 12 to to IN cord-008761-b36x05fn 63 13 expression expression NN cord-008761-b36x05fn 63 14 in in IN cord-008761-b36x05fn 63 15 E.coli E.coli NNS cord-008761-b36x05fn 63 16 , , , cord-008761-b36x05fn 63 17 in in IN cord-008761-b36x05fn 63 18 yeasts yeast NNS cord-008761-b36x05fn 63 19 or or CC cord-008761-b36x05fn 63 20 in in IN cord-008761-b36x05fn 63 21 mammalian mammalian JJ cord-008761-b36x05fn 63 22 cells cell NNS cord-008761-b36x05fn 63 23 . . . cord-008761-b36x05fn 64 1 This this DT cord-008761-b36x05fn 64 2 should should MD cord-008761-b36x05fn 64 3 allow allow VB cord-008761-b36x05fn 64 4 to to TO cord-008761-b36x05fn 64 5 produce produce VB cord-008761-b36x05fn 64 6 large large JJ cord-008761-b36x05fn 64 7 quantities quantity NNS cord-008761-b36x05fn 64 8 without without IN cord-008761-b36x05fn 64 9 great great JJ cord-008761-b36x05fn 64 10 technical technical JJ cord-008761-b36x05fn 64 11 difficulty difficulty NN cord-008761-b36x05fn 64 12 . . . cord-008761-b36x05fn 65 1 Especially especially RB cord-008761-b36x05fn 65 2 in in IN cord-008761-b36x05fn 65 3 the the DT cord-008761-b36x05fn 65 4 case case NN cord-008761-b36x05fn 65 5 of of IN cord-008761-b36x05fn 65 6 MuIFN MuIFN NNP cord-008761-b36x05fn 65 7 - - HYPH cord-008761-b36x05fn 65 8 y y NNP cord-008761-b36x05fn 65 9 , , , cord-008761-b36x05fn 65 10 this this DT cord-008761-b36x05fn 65 11 will will MD cord-008761-b36x05fn 65 12 be be VB cord-008761-b36x05fn 65 13 a a DT cord-008761-b36x05fn 65 14 great great JJ cord-008761-b36x05fn 65 15 advantage advantage NN cord-008761-b36x05fn 65 16 over over IN cord-008761-b36x05fn 65 17 the the DT cord-008761-b36x05fn 65 18 cumbersome cumbersome JJ cord-008761-b36x05fn 65 19 " " `` cord-008761-b36x05fn 65 20 natural natural JJ cord-008761-b36x05fn 65 21 " " '' cord-008761-b36x05fn 65 22 production production NN cord-008761-b36x05fn 65 23 method method NN cord-008761-b36x05fn 65 24 which which WDT cord-008761-b36x05fn 65 25 depends depend VBZ cord-008761-b36x05fn 65 26 on on IN cord-008761-b36x05fn 65 27 the the DT cord-008761-b36x05fn 65 28 availability availability NN cord-008761-b36x05fn 65 29 of of IN cord-008761-b36x05fn 65 30 fresh fresh JJ cord-008761-b36x05fn 65 31 mouse mouse NN cord-008761-b36x05fn 65 32 splenocytes splenocytes NNP cord-008761-b36x05fn 65 33 . . . cord-008761-b36x05fn 66 1 Pharmacokinetic pharmacokinetic JJ cord-008761-b36x05fn 66 2 studies study NNS cord-008761-b36x05fn 66 3 have have VBP cord-008761-b36x05fn 66 4 been be VBN cord-008761-b36x05fn 66 5 done do VBN cord-008761-b36x05fn 66 6 with with IN cord-008761-b36x05fn 66 7 human human JJ cord-008761-b36x05fn 66 8 interferons interferon NNS cord-008761-b36x05fn 66 9 - - : cord-008761-b36x05fn 66 10 a a NN cord-008761-b36x05fn 66 11 and and CC cord-008761-b36x05fn 66 12 -So -So . cord-008761-b36x05fn 67 1 In in IN cord-008761-b36x05fn 67 2 as as RB cord-008761-b36x05fn 67 3 far far RB cord-008761-b36x05fn 67 4 as as IN cord-008761-b36x05fn 67 5 they -PRON- PRP cord-008761-b36x05fn 67 6 were be VBD cord-008761-b36x05fn 67 7 done do VBN cord-008761-b36x05fn 67 8 in in IN cord-008761-b36x05fn 67 9 man man NN cord-008761-b36x05fn 67 10 , , , cord-008761-b36x05fn 67 11 they -PRON- PRP cord-008761-b36x05fn 67 12 are be VBP cord-008761-b36x05fn 67 13 of of IN cord-008761-b36x05fn 67 14 course course RB cord-008761-b36x05fn 67 15 quite quite RB cord-008761-b36x05fn 67 16 relevant relevant JJ cord-008761-b36x05fn 67 17 to to IN cord-008761-b36x05fn 67 18 the the DT cord-008761-b36x05fn 67 19 design design NN cord-008761-b36x05fn 67 20 of of IN cord-008761-b36x05fn 67 21 therapeutic therapeutic JJ cord-008761-b36x05fn 67 22 trials trial NNS cord-008761-b36x05fn 67 23 . . . cord-008761-b36x05fn 68 1 Studies study NNS cord-008761-b36x05fn 68 2 with with IN cord-008761-b36x05fn 68 3 these these DT cord-008761-b36x05fn 68 4 interferons interferon NNS cord-008761-b36x05fn 68 5 in in IN cord-008761-b36x05fn 68 6 animals animal NNS cord-008761-b36x05fn 68 7 are be VBP cord-008761-b36x05fn 68 8 of of IN cord-008761-b36x05fn 68 9 lesser less JJR cord-008761-b36x05fn 68 10 value value NN cord-008761-b36x05fn 68 11 , , , cord-008761-b36x05fn 68 12 especially especially RB cord-008761-b36x05fn 68 13 as as IN cord-008761-b36x05fn 68 14 it -PRON- PRP cord-008761-b36x05fn 68 15 has have VBZ cord-008761-b36x05fn 68 16 become become VBN cord-008761-b36x05fn 68 17 clear clear JJ cord-008761-b36x05fn 68 18 that that IN cord-008761-b36x05fn 68 19 comparative comparative JJ cord-008761-b36x05fn 68 20 studies study NNS cord-008761-b36x05fn 68 21 between between IN cord-008761-b36x05fn 68 22 interferon interferon NN cord-008761-b36x05fn 68 23 - - : cord-008761-b36x05fn 68 24 a a NN cord-008761-b36x05fn 68 25 and and CC cord-008761-b36x05fn 68 26 -S -S : cord-008761-b36x05fn 68 27 may may MD cord-008761-b36x05fn 68 28 yield yield VB cord-008761-b36x05fn 68 29 quite quite RB cord-008761-b36x05fn 68 30 different different JJ cord-008761-b36x05fn 68 31 conclusions conclusion NNS cord-008761-b36x05fn 68 32 depending depend VBG cord-008761-b36x05fn 68 33 on on IN cord-008761-b36x05fn 68 34 the the DT cord-008761-b36x05fn 68 35 animal animal NN cord-008761-b36x05fn 68 36 species specie NNS cord-008761-b36x05fn 68 37 used use VBN cord-008761-b36x05fn 68 38 ( ( -LRB- cord-008761-b36x05fn 68 39 9 9 CD cord-008761-b36x05fn 68 40 ) ) -RRB- cord-008761-b36x05fn 68 41 . . . cord-008761-b36x05fn 69 1 One one CD cord-008761-b36x05fn 69 2 of of IN cord-008761-b36x05fn 69 3 the the DT cord-008761-b36x05fn 69 4 key key JJ cord-008761-b36x05fn 69 5 questions question NNS cord-008761-b36x05fn 69 6 is be VBZ cord-008761-b36x05fn 69 7 to to TO cord-008761-b36x05fn 69 8 know know VB cord-008761-b36x05fn 69 9 whether whether IN cord-008761-b36x05fn 69 10 interferon interferon NN cord-008761-b36x05fn 69 11 given give VBN cord-008761-b36x05fn 69 12 by by IN cord-008761-b36x05fn 69 13 any any DT cord-008761-b36x05fn 69 14 route route NN cord-008761-b36x05fn 69 15 is be VBZ cord-008761-b36x05fn 69 16 concentrated concentrate VBN cord-008761-b36x05fn 69 17 in in IN cord-008761-b36x05fn 69 18 some some DT cord-008761-b36x05fn 69 19 organ organ NN cord-008761-b36x05fn 69 20 . . . cord-008761-b36x05fn 70 1 This this DT cord-008761-b36x05fn 70 2 question question NN cord-008761-b36x05fn 70 3 has have VBZ cord-008761-b36x05fn 70 4 so so RB cord-008761-b36x05fn 70 5 far far RB cord-008761-b36x05fn 70 6 not not RB cord-008761-b36x05fn 70 7 been be VBN cord-008761-b36x05fn 70 8 studied study VBN cord-008761-b36x05fn 70 9 in in IN cord-008761-b36x05fn 70 10 man man NN cord-008761-b36x05fn 70 11 although although IN cord-008761-b36x05fn 70 12 , , , cord-008761-b36x05fn 70 13 with with IN cord-008761-b36x05fn 70 14 current current JJ cord-008761-b36x05fn 70 15 techniques technique NNS cord-008761-b36x05fn 70 16 of of IN cord-008761-b36x05fn 70 17 production production NN cord-008761-b36x05fn 70 18 and and CC cord-008761-b36x05fn 70 19 radioactive radioactive JJ cord-008761-b36x05fn 70 20 scanning scanning NN cord-008761-b36x05fn 70 21 , , , cord-008761-b36x05fn 70 22 it -PRON- PRP cord-008761-b36x05fn 70 23 seems seem VBZ cord-008761-b36x05fn 70 24 quite quite RB cord-008761-b36x05fn 70 25 approachable approachable JJ cord-008761-b36x05fn 70 26 . . . cord-008761-b36x05fn 71 1 That that IN cord-008761-b36x05fn 71 2 the the DT cord-008761-b36x05fn 71 3 question question NN cord-008761-b36x05fn 71 4 is be VBZ cord-008761-b36x05fn 71 5 not not RB cord-008761-b36x05fn 71 6 trivial trivial JJ cord-008761-b36x05fn 71 7 may may MD cord-008761-b36x05fn 71 8 be be VB cord-008761-b36x05fn 71 9 apparent apparent JJ cord-008761-b36x05fn 71 10 from from IN cord-008761-b36x05fn 71 11 the the DT cord-008761-b36x05fn 71 12 observation observation NN cord-008761-b36x05fn 71 13 that that IN cord-008761-b36x05fn 71 14 human human JJ cord-008761-b36x05fn 71 15 interferon interferon NN cord-008761-b36x05fn 71 16 - - : cord-008761-b36x05fn 71 17 a a NN cord-008761-b36x05fn 71 18 and and CC cord-008761-b36x05fn 71 19 -S -s NN cord-008761-b36x05fn 71 20 , , , cord-008761-b36x05fn 71 21 when when WRB cord-008761-b36x05fn 71 22 injected inject VBN cord-008761-b36x05fn 71 23 by by IN cord-008761-b36x05fn 71 24 the the DT cord-008761-b36x05fn 71 25 intramuscular intramuscular JJ cord-008761-b36x05fn 71 26 route route NN cord-008761-b36x05fn 71 27 , , , cord-008761-b36x05fn 71 28 cause cause IN cord-008761-b36x05fn 71 29 comparable comparable JJ cord-008761-b36x05fn 71 30 increases increase NNS cord-008761-b36x05fn 71 31 in in IN cord-008761-b36x05fn 71 32 NK nk NN cord-008761-b36x05fn 71 33 - - HYPH cord-008761-b36x05fn 71 34 cell cell NN cord-008761-b36x05fn 71 35 activity activity NN cord-008761-b36x05fn 71 36 , , , cord-008761-b36x05fn 71 37 although although IN cord-008761-b36x05fn 71 38 blood blood NN cord-008761-b36x05fn 71 39 levels level NNS cord-008761-b36x05fn 71 40 with with IN cord-008761-b36x05fn 71 41 interferon interferon NN cord-008761-b36x05fn 71 42 - - : cord-008761-b36x05fn 71 43 a a NN cord-008761-b36x05fn 71 44 are be VBP cord-008761-b36x05fn 71 45 10-to 10-to CD cord-008761-b36x05fn 71 46 100-fold 100-fold CD cord-008761-b36x05fn 71 47 higher high JJR cord-008761-b36x05fn 71 48 ( ( -LRB- cord-008761-b36x05fn 71 49 10 10 CD cord-008761-b36x05fn 71 50 ) ) -RRB- cord-008761-b36x05fn 71 51 . . . cord-008761-b36x05fn 72 1 Similarly similarly RB cord-008761-b36x05fn 72 2 , , , cord-008761-b36x05fn 72 3 studies study NNS cord-008761-b36x05fn 72 4 in in IN cord-008761-b36x05fn 72 5 mice mouse NNS cord-008761-b36x05fn 72 6 have have VBP cord-008761-b36x05fn 72 7 revealed reveal VBN cord-008761-b36x05fn 72 8 that that IN cord-008761-b36x05fn 72 9 human human JJ cord-008761-b36x05fn 72 10 interferon interferon NN cord-008761-b36x05fn 72 11 - - : cord-008761-b36x05fn 72 12 a a NN cord-008761-b36x05fn 72 13 and and CC cord-008761-b36x05fn 72 14 -S -S . cord-008761-b36x05fn 73 1 given give VBN cord-008761-b36x05fn 73 2 intraperitoneally intraperitoneally RB cord-008761-b36x05fn 73 3 , , , cord-008761-b36x05fn 73 4 yield yield VB cord-008761-b36x05fn 73 5 different different JJ cord-008761-b36x05fn 73 6 blood blood NN cord-008761-b36x05fn 73 7 levels level NNS cord-008761-b36x05fn 73 8 but but CC cord-008761-b36x05fn 73 9 quite quite RB cord-008761-b36x05fn 73 10 similar similar JJ cord-008761-b36x05fn 73 11 tissue tissue NN cord-008761-b36x05fn 73 12 levels level NNS cord-008761-b36x05fn 73 13 ( ( -LRB- cord-008761-b36x05fn 73 14 II II NNP cord-008761-b36x05fn 73 15 ) ) -RRB- cord-008761-b36x05fn 73 16 . . . cord-008761-b36x05fn 74 1 There there EX cord-008761-b36x05fn 74 2 is be VBZ cord-008761-b36x05fn 74 3 evidence evidence NN cord-008761-b36x05fn 74 4 that that IN cord-008761-b36x05fn 74 5 some some DT cord-008761-b36x05fn 74 6 organs organ NNS cord-008761-b36x05fn 74 7 , , , cord-008761-b36x05fn 74 8 in in IN cord-008761-b36x05fn 74 9 particular particular JJ cord-008761-b36x05fn 74 10 the the DT cord-008761-b36x05fn 74 11 brain brain NN cord-008761-b36x05fn 74 12 , , , cord-008761-b36x05fn 74 13 are be VBP cord-008761-b36x05fn 74 14 rather rather RB cord-008761-b36x05fn 74 15 difficult difficult JJ cord-008761-b36x05fn 74 16 to to TO cord-008761-b36x05fn 74 17 penetrate penetrate VB cord-008761-b36x05fn 74 18 by by IN cord-008761-b36x05fn 74 19 interferons interferon NNS cord-008761-b36x05fn 74 20 . . . cord-008761-b36x05fn 75 1 Thus thus RB cord-008761-b36x05fn 75 2 , , , cord-008761-b36x05fn 75 3 during during IN cord-008761-b36x05fn 75 4 the the DT cord-008761-b36x05fn 75 5 initial initial JJ cord-008761-b36x05fn 75 6 phases phase NNS cord-008761-b36x05fn 75 7 of of IN cord-008761-b36x05fn 75 8 experimental experimental JJ cord-008761-b36x05fn 75 9 mengo mengo NNS cord-008761-b36x05fn 75 10 virus virus NN cord-008761-b36x05fn 75 11 infection infection NN cord-008761-b36x05fn 75 12 in in IN cord-008761-b36x05fn 75 13 mice mouse NNS cord-008761-b36x05fn 75 14 , , , cord-008761-b36x05fn 75 15 interferon interferon NN cord-008761-b36x05fn 75 16 levels level NNS cord-008761-b36x05fn 75 17 in in IN cord-008761-b36x05fn 75 18 serum serum NN cord-008761-b36x05fn 75 19 being be VBG cord-008761-b36x05fn 75 20 quite quite RB cord-008761-b36x05fn 75 21 high high JJ cord-008761-b36x05fn 75 22 , , , cord-008761-b36x05fn 75 23 no no DT cord-008761-b36x05fn 75 24 interferon interferon NN cord-008761-b36x05fn 75 25 was be VBD cord-008761-b36x05fn 75 26 detectable detectable JJ cord-008761-b36x05fn 75 27 in in IN cord-008761-b36x05fn 75 28 the the DT cord-008761-b36x05fn 75 29 brain brain NN cord-008761-b36x05fn 75 30 ( ( -LRB- cord-008761-b36x05fn 75 31 12 12 CD cord-008761-b36x05fn 75 32 ) ) -RRB- cord-008761-b36x05fn 75 33 . . . cord-008761-b36x05fn 76 1 Brain brain NN cord-008761-b36x05fn 76 2 interferon interferon NN cord-008761-b36x05fn 76 3 became become VBD cord-008761-b36x05fn 76 4 detectable detectable JJ cord-008761-b36x05fn 76 5 only only RB cord-008761-b36x05fn 76 6 in in IN cord-008761-b36x05fn 76 7 later later JJ cord-008761-b36x05fn 76 8 stages stage NNS cord-008761-b36x05fn 76 9 of of IN cord-008761-b36x05fn 76 10 the the DT cord-008761-b36x05fn 76 11 infection infection NN cord-008761-b36x05fn 76 12 when when WRB cord-008761-b36x05fn 76 13 full full RB cord-008761-b36x05fn 76 14 - - HYPH cord-008761-b36x05fn 76 15 blown blow VBN cord-008761-b36x05fn 76 16 virus virus NN cord-008761-b36x05fn 76 17 replication replication NN cord-008761-b36x05fn 76 18 had have VBD cord-008761-b36x05fn 76 19 started start VBN cord-008761-b36x05fn 76 20 in in IN cord-008761-b36x05fn 76 21 the the DT cord-008761-b36x05fn 76 22 brain brain NN cord-008761-b36x05fn 76 23 itself -PRON- PRP cord-008761-b36x05fn 76 24 . . . cord-008761-b36x05fn 77 1 HuIFN HuIFN NNP cord-008761-b36x05fn 77 2 - - HYPH cord-008761-b36x05fn 77 3 S S NNP cord-008761-b36x05fn 77 4 on on IN cord-008761-b36x05fn 77 5 the the DT cord-008761-b36x05fn 77 6 other other JJ cord-008761-b36x05fn 77 7 hand hand NN cord-008761-b36x05fn 77 8 undergoes undergo VBZ cord-008761-b36x05fn 77 9 rapid rapid JJ cord-008761-b36x05fn 77 10 uptake uptake NN cord-008761-b36x05fn 77 11 , , , cord-008761-b36x05fn 77 12 suggesting suggest VBG cord-008761-b36x05fn 77 13 that that IN cord-008761-b36x05fn 77 14 desialylation desialylation NN cord-008761-b36x05fn 77 15 , , , cord-008761-b36x05fn 77 16 wherever wherever WRB cord-008761-b36x05fn 77 17 it -PRON- PRP cord-008761-b36x05fn 77 18 may may MD cord-008761-b36x05fn 77 19 take take VB cord-008761-b36x05fn 77 20 place place NN cord-008761-b36x05fn 77 21 , , , cord-008761-b36x05fn 77 22 is be VBZ cord-008761-b36x05fn 77 23 a a DT cord-008761-b36x05fn 77 24 first first JJ cord-008761-b36x05fn 77 25 step step NN cord-008761-b36x05fn 77 26 toward toward IN cord-008761-b36x05fn 77 27 degradation degradation NN cord-008761-b36x05fn 77 28 of of IN cord-008761-b36x05fn 77 29 HuIFN HuIFN NNP cord-008761-b36x05fn 77 30 - - HYPH cord-008761-b36x05fn 77 31 S. S. NNP cord-008761-b36x05fn 78 1 The the DT cord-008761-b36x05fn 78 2 kidney kidney NN cord-008761-b36x05fn 78 3 was be VBD cord-008761-b36x05fn 78 4 shown show VBN cord-008761-b36x05fn 78 5 to to IN cord-008761-b36x05fn 78 6 playa playa NNP cord-008761-b36x05fn 78 7 key key JJ cord-008761-b36x05fn 78 8 role role NN cord-008761-b36x05fn 78 9 in in IN cord-008761-b36x05fn 78 10 that that DT cord-008761-b36x05fn 78 11 interferons interferon NNS cord-008761-b36x05fn 78 12 seem seem VBP cord-008761-b36x05fn 78 13 to to TO cord-008761-b36x05fn 78 14 pass pass VB cord-008761-b36x05fn 78 15 easily easily RB cord-008761-b36x05fn 78 16 through through IN cord-008761-b36x05fn 78 17 the the DT cord-008761-b36x05fn 78 18 glomerular glomerular JJ cord-008761-b36x05fn 78 19 sieve sieve NN cord-008761-b36x05fn 78 20 and and CC cord-008761-b36x05fn 78 21 to to TO cord-008761-b36x05fn 78 22 be be VB cord-008761-b36x05fn 78 23 taken take VBN cord-008761-b36x05fn 78 24 up up RP cord-008761-b36x05fn 78 25 and and CC cord-008761-b36x05fn 78 26 degraded degrade VBN cord-008761-b36x05fn 78 27 by by IN cord-008761-b36x05fn 78 28 tubular tubular JJ cord-008761-b36x05fn 78 29 cells cell NNS cord-008761-b36x05fn 78 30 . . . cord-008761-b36x05fn 79 1 Of of IN cord-008761-b36x05fn 79 2 particular particular JJ cord-008761-b36x05fn 79 3 importance importance NN cord-008761-b36x05fn 79 4 are be VBP cord-008761-b36x05fn 79 5 pharmacokinetic pharmacokinetic JJ cord-008761-b36x05fn 79 6 studies study NNS cord-008761-b36x05fn 79 7 with with IN cord-008761-b36x05fn 79 8 rDd rDd NNS cord-008761-b36x05fn 79 9 - - : cord-008761-b36x05fn 79 10 interferons interferon NNS cord-008761-b36x05fn 79 11 . . . cord-008761-b36x05fn 80 1 Since since IN cord-008761-b36x05fn 80 2 these these DT cord-008761-b36x05fn 80 3 interferons interferon NNS cord-008761-b36x05fn 80 4 often often RB cord-008761-b36x05fn 80 5 differ differ VBP cord-008761-b36x05fn 80 6 from from IN cord-008761-b36x05fn 80 7 the the DT cord-008761-b36x05fn 80 8 natural natural JJ cord-008761-b36x05fn 80 9 ones one NNS cord-008761-b36x05fn 80 10 . . . cord-008761-b36x05fn 81 1 bY by IN cord-008761-b36x05fn 81 2 , , , cord-008761-b36x05fn 81 3 the the DT cord-008761-b36x05fn 81 4 absence absence NN cord-008761-b36x05fn 81 5 of of IN cord-008761-b36x05fn 81 6 carbohydrate carbohydrate NN cord-008761-b36x05fn 81 7 side side NN cord-008761-b36x05fn 81 8 - - HYPH cord-008761-b36x05fn 81 9 chains chain NNS cord-008761-b36x05fn 81 10 it -PRON- PRP cord-008761-b36x05fn 81 11 may may MD cord-008761-b36x05fn 81 12 be be VB cord-008761-b36x05fn 81 13 expected expect VBN cord-008761-b36x05fn 81 14 that that IN cord-008761-b36x05fn 81 15 their -PRON- PRP$ cord-008761-b36x05fn 81 16 pharmacokinetics pharmacokinetic NNS cord-008761-b36x05fn 81 17 will will MD cord-008761-b36x05fn 81 18 be be VB cord-008761-b36x05fn 81 19 quantitatively quantitatively RB cord-008761-b36x05fn 81 20 different different JJ cord-008761-b36x05fn 81 21 from from IN cord-008761-b36x05fn 81 22 those those DT cord-008761-b36x05fn 81 23 of of IN cord-008761-b36x05fn 81 24 their -PRON- PRP$ cord-008761-b36x05fn 81 25 natural natural JJ cord-008761-b36x05fn 81 26 counterparts counterpart NNS cord-008761-b36x05fn 81 27 . . . cord-008761-b36x05fn 82 1 It -PRON- PRP cord-008761-b36x05fn 82 2 is be VBZ cord-008761-b36x05fn 82 3 not not RB cord-008761-b36x05fn 82 4 unthinkable unthinkable JJ cord-008761-b36x05fn 82 5 that that IN cord-008761-b36x05fn 82 6 some some DT cord-008761-b36x05fn 82 7 of of IN cord-008761-b36x05fn 82 8 the the DT cord-008761-b36x05fn 82 9 artificial artificial JJ cord-008761-b36x05fn 82 10 interferons interferon NNS cord-008761-b36x05fn 82 11 . . . cord-008761-b36x05fn 83 1 ( ( -LRB- cord-008761-b36x05fn 83 2 e.g. e.g. IN cord-008761-b36x05fn 83 3 those those DT cord-008761-b36x05fn 83 4 obtained obtain VBN cord-008761-b36x05fn 83 5 by by IN cord-008761-b36x05fn 83 6 sitespecific sitespecific NNP cord-008761-b36x05fn 83 7 mutagenesis mutagenesis NNP cord-008761-b36x05fn 83 8 ) ) -RRB- cord-008761-b36x05fn 83 9 may may MD cord-008761-b36x05fn 83 10 be be VB cord-008761-b36x05fn 83 11 degraded degrade VBN cord-008761-b36x05fn 83 12 slowly slowly RB cord-008761-b36x05fn 83 13 by by IN cord-008761-b36x05fn 83 14 the the DT cord-008761-b36x05fn 83 15 organism organism NN cord-008761-b36x05fn 83 16 , , , cord-008761-b36x05fn 83 17 allowing allow VBG cord-008761-b36x05fn 83 18 to to TO cord-008761-b36x05fn 83 19 decrease decrease VB cord-008761-b36x05fn 83 20 the the DT cord-008761-b36x05fn 83 21 doses dose NNS cord-008761-b36x05fn 83 22 . . . cord-008761-b36x05fn 84 1 However however RB cord-008761-b36x05fn 84 2 , , , cord-008761-b36x05fn 84 3 there there EX cord-008761-b36x05fn 84 4 is be VBZ cord-008761-b36x05fn 84 5 nothing nothing NN cord-008761-b36x05fn 84 6 that that WDT cord-008761-b36x05fn 84 7 would would MD cord-008761-b36x05fn 84 8 lead lead VB cord-008761-b36x05fn 84 9 one one PRP cord-008761-b36x05fn 84 10 to to TO cord-008761-b36x05fn 84 11 think think VB cord-008761-b36x05fn 84 12 that that IN cord-008761-b36x05fn 84 13 site site NN cord-008761-b36x05fn 84 14 - - HYPH cord-008761-b36x05fn 84 15 specific specific JJ cord-008761-b36x05fn 84 16 mutagenesis mutagenesis NN cord-008761-b36x05fn 84 17 . . . cord-008761-b36x05fn 85 1 may may MD cord-008761-b36x05fn 85 2 enable enable VB cord-008761-b36x05fn 85 3 one one PRP cord-008761-b36x05fn 85 4 to to TO cord-008761-b36x05fn 85 5 target target VB cord-008761-b36x05fn 85 6 an an DT cord-008761-b36x05fn 85 7 interferon interferon NN cord-008761-b36x05fn 85 8 to to IN cord-008761-b36x05fn 85 9 a a DT cord-008761-b36x05fn 85 10 specific specific JJ cord-008761-b36x05fn 85 11 , , , cord-008761-b36x05fn 85 12 The the DT cord-008761-b36x05fn 85 13 main main JJ cord-008761-b36x05fn 85 14 lesson lesson NN cord-008761-b36x05fn 85 15 to to TO cord-008761-b36x05fn 85 16 be be VB cord-008761-b36x05fn 85 17 learned learn VBN cord-008761-b36x05fn 85 18 from from IN cord-008761-b36x05fn 85 19 these these DT cord-008761-b36x05fn 85 20 experiments experiment NNS cord-008761-b36x05fn 85 21 is be VBZ cord-008761-b36x05fn 85 22 that that IN cord-008761-b36x05fn 85 23 interferon interferon NN cord-008761-b36x05fn 85 24 therapy therapy NN cord-008761-b36x05fn 85 25 is be VBZ cord-008761-b36x05fn 85 26 unlikely unlikely JJ cord-008761-b36x05fn 85 27 to to TO cord-008761-b36x05fn 85 28 achieve achieve VB cord-008761-b36x05fn 85 29 protective protective JJ cord-008761-b36x05fn 85 30 effects effect NNS cord-008761-b36x05fn 85 31 unless unless IN cord-008761-b36x05fn 85 32 started start VBD cord-008761-b36x05fn 85 33 before before IN cord-008761-b36x05fn 85 34 the the DT cord-008761-b36x05fn 85 35 major major JJ cord-008761-b36x05fn 85 36 viral viral JJ cord-008761-b36x05fn 85 37 replication replication NN cord-008761-b36x05fn 85 38 burst burst VBD cord-008761-b36x05fn 85 39 in in IN cord-008761-b36x05fn 85 40 the the DT cord-008761-b36x05fn 85 41 organism organism NN cord-008761-b36x05fn 85 42 . . . cord-008761-b36x05fn 86 1 In in IN cord-008761-b36x05fn 86 2 general general JJ cord-008761-b36x05fn 86 3 one one NN cord-008761-b36x05fn 86 4 can can MD cord-008761-b36x05fn 86 5 say say VB cord-008761-b36x05fn 86 6 that that IN cord-008761-b36x05fn 86 7 this this DT cord-008761-b36x05fn 86 8 means mean VBZ cord-008761-b36x05fn 86 9 that that IN cord-008761-b36x05fn 86 10 therapy therapy NN cord-008761-b36x05fn 86 11 has have VBZ cord-008761-b36x05fn 86 12 to to TO cord-008761-b36x05fn 86 13 be be VB cord-008761-b36x05fn 86 14 started start VBN cord-008761-b36x05fn 86 15 before before IN cord-008761-b36x05fn 86 16 the the DT cord-008761-b36x05fn 86 17 first first JJ cord-008761-b36x05fn 86 18 symptoms symptom NNS cord-008761-b36x05fn 86 19 . . . cord-008761-b36x05fn 87 1 As as IN cord-008761-b36x05fn 87 2 already already RB cord-008761-b36x05fn 87 3 mentioned mention VBN cord-008761-b36x05fn 87 4 , , , cord-008761-b36x05fn 87 5 mouse mouse NN cord-008761-b36x05fn 87 6 model model NN cord-008761-b36x05fn 87 7 systems system NNS cord-008761-b36x05fn 87 8 for for IN cord-008761-b36x05fn 87 9 chronic chronic JJ cord-008761-b36x05fn 87 10 virus virus NN cord-008761-b36x05fn 87 11 infections infection NNS cord-008761-b36x05fn 87 12 are be VBP cord-008761-b36x05fn 87 13 scarce scarce JJ cord-008761-b36x05fn 87 14 . . . cord-008761-b36x05fn 88 1 One one CD cord-008761-b36x05fn 88 2 example example NN cord-008761-b36x05fn 88 3 is be VBZ cord-008761-b36x05fn 88 4 experimental experimental JJ cord-008761-b36x05fn 88 5 viral viral JJ cord-008761-b36x05fn 88 6 leukemia leukemia NN cord-008761-b36x05fn 88 7 . . . cord-008761-b36x05fn 89 1 It -PRON- PRP cord-008761-b36x05fn 89 2 has have VBZ cord-008761-b36x05fn 89 3 been be VBN cord-008761-b36x05fn 89 4 known know VBN cord-008761-b36x05fn 89 5 for for IN cord-008761-b36x05fn 89 6 a a DT cord-008761-b36x05fn 89 7 long long JJ cord-008761-b36x05fn 89 8 time time NN cord-008761-b36x05fn 89 9 that that WDT cord-008761-b36x05fn 89 10 continuous continuous JJ cord-008761-b36x05fn 89 11 interferon interferon NNP cord-008761-b36x05fn 89 12 administration administration NN cord-008761-b36x05fn 89 13 started start VBD cord-008761-b36x05fn 89 14 before before RB cord-008761-b36x05fn 89 15 or or CC cord-008761-b36x05fn 89 16 shortly shortly RB cord-008761-b36x05fn 89 17 after after IN cord-008761-b36x05fn 89 18 infection infection NN cord-008761-b36x05fn 89 19 can can MD cord-008761-b36x05fn 89 20 significantly significantly RB cord-008761-b36x05fn 89 21 delay delay VB cord-008761-b36x05fn 89 22 the the DT cord-008761-b36x05fn 89 23 development development NN cord-008761-b36x05fn 89 24 of of IN cord-008761-b36x05fn 89 25 the the DT cord-008761-b36x05fn 89 26 disease disease NN cord-008761-b36x05fn 89 27 and and CC cord-008761-b36x05fn 89 28 can can MD cord-008761-b36x05fn 89 29 also also RB cord-008761-b36x05fn 89 30 prolong prolong VB cord-008761-b36x05fn 89 31 survival survival NN cord-008761-b36x05fn 89 32 time time NN cord-008761-b36x05fn 89 33 ( ( -LRB- cord-008761-b36x05fn 89 34 16 16 CD cord-008761-b36x05fn 89 35 ) ) -RRB- cord-008761-b36x05fn 89 36 . . . cord-008761-b36x05fn 90 1 This this DT cord-008761-b36x05fn 90 2 finding finding NN cord-008761-b36x05fn 90 3 may may MD cord-008761-b36x05fn 90 4 be be VB cord-008761-b36x05fn 90 5 expected expect VBN cord-008761-b36x05fn 90 6 to to TO cord-008761-b36x05fn 90 7 receive receive VB cord-008761-b36x05fn 90 8 renewed renew VBN cord-008761-b36x05fn 90 9 in- in- NNP cord-008761-b36x05fn 90 10 ( ( -LRB- cord-008761-b36x05fn 90 11 17 17 CD cord-008761-b36x05fn 90 12 , , , cord-008761-b36x05fn 90 13 18 18 CD cord-008761-b36x05fn 90 14 , , , cord-008761-b36x05fn 90 15 19 19 CD cord-008761-b36x05fn 90 16 ) ) -RRB- cord-008761-b36x05fn 90 17 . . . cord-008761-b36x05fn 91 1 The the DT cord-008761-b36x05fn 91 2 question question NN cord-008761-b36x05fn 91 3 whether whether IN cord-008761-b36x05fn 91 4 interferon interferon NN cord-008761-b36x05fn 91 5 therapy therapy NN cord-008761-b36x05fn 91 6 may may MD cord-008761-b36x05fn 91 7 be be VB cord-008761-b36x05fn 91 8 able able JJ cord-008761-b36x05fn 91 9 to to TO cord-008761-b36x05fn 91 10 control control VB cord-008761-b36x05fn 91 11 chronic chronic JJ cord-008761-b36x05fn 91 12 or or CC cord-008761-b36x05fn 91 13 recurrent recurrent JJ cord-008761-b36x05fn 91 14 disease disease NN cord-008761-b36x05fn 91 15 at at IN cord-008761-b36x05fn 91 16 the the DT cord-008761-b36x05fn 91 17 level level NN cord-008761-b36x05fn 91 18 of of IN cord-008761-b36x05fn 91 19 the the DT cord-008761-b36x05fn 91 20 whole whole JJ cord-008761-b36x05fn 91 21 body body NN cord-008761-b36x05fn 91 22 , , , cord-008761-b36x05fn 91 23 is be VBZ cord-008761-b36x05fn 91 24 confounded confound VBN cord-008761-b36x05fn 91 25 by by IN cord-008761-b36x05fn 91 26 the the DT cord-008761-b36x05fn 91 27 fact fact NN cord-008761-b36x05fn 91 28 that that IN cord-008761-b36x05fn 91 29 much much JJ cord-008761-b36x05fn 91 30 of of IN cord-008761-b36x05fn 91 31 the the DT cord-008761-b36x05fn 91 32 symptoms symptom NNS cord-008761-b36x05fn 91 33 of of IN cord-008761-b36x05fn 91 34 these these DT cord-008761-b36x05fn 91 35 chronic chronic JJ cord-008761-b36x05fn 91 36 virus virus NN cord-008761-b36x05fn 91 37 diseases disease NNS cord-008761-b36x05fn 91 38 are be VBP cord-008761-b36x05fn 91 39 not not RB cord-008761-b36x05fn 91 40 directly directly RB cord-008761-b36x05fn 91 41 due due JJ cord-008761-b36x05fn 91 42 to to IN cord-008761-b36x05fn 91 43 viral viral JJ cord-008761-b36x05fn 91 44 replication replication NN cord-008761-b36x05fn 91 45 or or CC cord-008761-b36x05fn 91 46 cytopathogenicity cytopathogenicity NN cord-008761-b36x05fn 91 47 but but CC cord-008761-b36x05fn 91 48 result result NN cord-008761-b36x05fn 91 49 from from IN cord-008761-b36x05fn 91 50 immunological immunological JJ cord-008761-b36x05fn 91 51 and and CC cord-008761-b36x05fn 91 52 inflammatory inflammatory JJ cord-008761-b36x05fn 91 53 reactions reaction NNS cord-008761-b36x05fn 91 54 . . . cord-008761-b36x05fn 92 1 Therefore therefore RB cord-008761-b36x05fn 92 2 , , , cord-008761-b36x05fn 92 3 it -PRON- PRP cord-008761-b36x05fn 92 4 is be VBZ cord-008761-b36x05fn 92 5 not not RB cord-008761-b36x05fn 92 6 clear clear JJ cord-008761-b36x05fn 92 7 whether whether IN cord-008761-b36x05fn 92 8 alleviation alleviation NN cord-008761-b36x05fn 92 9 of of IN cord-008761-b36x05fn 92 10 symptoms symptom NNS cord-008761-b36x05fn 92 11 by by IN cord-008761-b36x05fn 92 12 interferon interferon NN cord-008761-b36x05fn 92 13 is be VBZ cord-008761-b36x05fn 92 14 due due JJ cord-008761-b36x05fn 92 15 to to IN cord-008761-b36x05fn 92 16 antiviral antiviral JJ cord-008761-b36x05fn 92 17 activity activity NN cord-008761-b36x05fn 92 18 or or CC cord-008761-b36x05fn 92 19 to to TO cord-008761-b36x05fn 92 20 interference interference VB cord-008761-b36x05fn 92 21 with with IN cord-008761-b36x05fn 92 22 secondary secondary JJ cord-008761-b36x05fn 92 23 effects effect NNS cord-008761-b36x05fn 92 24 . . . cord-008761-b36x05fn 93 1 Thus thus RB cord-008761-b36x05fn 93 2 , , , cord-008761-b36x05fn 93 3 in in IN cord-008761-b36x05fn 93 4 the the DT cord-008761-b36x05fn 93 5 aforementioned aforementioned JJ cord-008761-b36x05fn 93 6 example example NN cord-008761-b36x05fn 93 7 of of IN cord-008761-b36x05fn 93 8 Friend friend NN cord-008761-b36x05fn 93 9 leukemia leukemia NN cord-008761-b36x05fn 93 10 in in IN cord-008761-b36x05fn 93 11 mice mice NN cord-008761-b36x05fn 93 12 , , , cord-008761-b36x05fn 93 13 it -PRON- PRP cord-008761-b36x05fn 93 14 is be VBZ cord-008761-b36x05fn 93 15 not not RB cord-008761-b36x05fn 93 16 clear clear JJ cord-008761-b36x05fn 93 17 whether whether IN cord-008761-b36x05fn 93 18 delay delay NN cord-008761-b36x05fn 93 19 in in IN cord-008761-b36x05fn 93 20 splenomegaly splenomegaly JJ cord-008761-b36x05fn 93 21 development development NN cord-008761-b36x05fn 93 22 is be VBZ cord-008761-b36x05fn 93 23 due due JJ cord-008761-b36x05fn 93 24 to to IN cord-008761-b36x05fn 93 25 reduction reduction NN cord-008761-b36x05fn 93 26 in in IN cord-008761-b36x05fn 93 27 viral viral JJ cord-008761-b36x05fn 93 28 load load NN cord-008761-b36x05fn 93 29 or or CC cord-008761-b36x05fn 93 30 to to TO cord-008761-b36x05fn 93 31 antimitotic antimitotic VB cord-008761-b36x05fn 93 32 or or CC cord-008761-b36x05fn 93 33 immunoregulatory immunoregulatory JJ cord-008761-b36x05fn 93 34 effects effect NNS cord-008761-b36x05fn 93 35 of of IN cord-008761-b36x05fn 93 36 interferon interferon NN cord-008761-b36x05fn 93 37 . . . cord-008761-b36x05fn 94 1 Recurrent recurrent JJ cord-008761-b36x05fn 94 2 herpetic herpetic JJ cord-008761-b36x05fn 94 3 keratitis keratitis NN cord-008761-b36x05fn 94 4 ( ( -LRB- cord-008761-b36x05fn 94 5 25 25 CD cord-008761-b36x05fn 94 6 ) ) -RRB- cord-008761-b36x05fn 94 7 can can MD cord-008761-b36x05fn 94 8 benefit benefit VB cord-008761-b36x05fn 94 9 from from IN cord-008761-b36x05fn 94 10 topical topical JJ cord-008761-b36x05fn 94 11 interferon interferon NN cord-008761-b36x05fn 94 12 therapy therapy NN cord-008761-b36x05fn 94 13 if if IN cord-008761-b36x05fn 94 14 it -PRON- PRP cord-008761-b36x05fn 94 15 is be VBZ cord-008761-b36x05fn 94 16 given give VBN cord-008761-b36x05fn 94 17 in in IN cord-008761-b36x05fn 94 18 conjunction conjunction NN cord-008761-b36x05fn 94 19 with with IN cord-008761-b36x05fn 94 20 debridement debridement NN cord-008761-b36x05fn 94 21 and/or and/or CC cord-008761-b36x05fn 94 22 with with IN cord-008761-b36x05fn 94 23 some some DT cord-008761-b36x05fn 94 24 of of IN cord-008761-b36x05fn 94 25 the the DT cord-008761-b36x05fn 94 26 older old JJR cord-008761-b36x05fn 94 27 or or CC cord-008761-b36x05fn 94 28 newer new JJR cord-008761-b36x05fn 94 29 antiherpetics antiherpetic NNS cord-008761-b36x05fn 94 30 ( ( -LRB- cord-008761-b36x05fn 94 31 25 25 CD cord-008761-b36x05fn 94 32 ) ) -RRB- cord-008761-b36x05fn 94 33 . . . cord-008761-b36x05fn 95 1 Acute acute JJ cord-008761-b36x05fn 95 2 rhinopharyngitis rhinopharyngitis NN cord-008761-b36x05fn 95 3 due due IN cord-008761-b36x05fn 95 4 to to IN cord-008761-b36x05fn 95 5 rhinovirus rhinovirus NN cord-008761-b36x05fn 95 6 or or CC cord-008761-b36x05fn 95 7 coronavirus coronavirus NN cord-008761-b36x05fn 95 8 infections infection NNS cord-008761-b36x05fn 95 9 can can MD cord-008761-b36x05fn 95 10 favorably favorably RB cord-008761-b36x05fn 95 11 be be VB cord-008761-b36x05fn 95 12 influenced influence VBN cord-008761-b36x05fn 95 13 if if IN cord-008761-b36x05fn 95 14 rather rather RB cord-008761-b36x05fn 95 15 high high JJ cord-008761-b36x05fn 95 16 doses dose NNS cord-008761-b36x05fn 95 17 of of IN cord-008761-b36x05fn 95 18 HuIFN HuIFN NNP cord-008761-b36x05fn 95 19 - - HYPH cord-008761-b36x05fn 95 20 a a DT cord-008761-b36x05fn 95 21 ( ( -LRB- cord-008761-b36x05fn 95 22 but but CC cord-008761-b36x05fn 95 23 not not RB cord-008761-b36x05fn 95 24 -S -S . cord-008761-b36x05fn 95 25 ) ) -RRB- cord-008761-b36x05fn 95 26 ( ( -LRB- cord-008761-b36x05fn 95 27 23 23 CD cord-008761-b36x05fn 95 28 ) ) -RRB- cord-008761-b36x05fn 95 29 are be VBP cord-008761-b36x05fn 95 30 given give VBN cord-008761-b36x05fn 95 31 and and CC cord-008761-b36x05fn 95 32 if if IN cord-008761-b36x05fn 95 33 treatment treatment NN cord-008761-b36x05fn 95 34 is be VBZ cord-008761-b36x05fn 95 35 started start VBN cord-008761-b36x05fn 95 36 early early RB cord-008761-b36x05fn 95 37 , , , cord-008761-b36x05fn 95 38 preferentially preferentially RB cord-008761-b36x05fn 95 39 before before IN cord-008761-b36x05fn 95 40 infection infection NN cord-008761-b36x05fn 95 41 . . . cord-008761-b36x05fn 96 1 It -PRON- PRP cord-008761-b36x05fn 96 2 has have VBZ cord-008761-b36x05fn 96 3 been be VBN cord-008761-b36x05fn 96 4 envisaged envisage VBN cord-008761-b36x05fn 96 5 to to TO cord-008761-b36x05fn 96 6 use use VB cord-008761-b36x05fn 96 7 daily daily JJ cord-008761-b36x05fn 96 8 instillations instillation NNS cord-008761-b36x05fn 96 9 of of IN cord-008761-b36x05fn 96 10 interferon interferon NN cord-008761-b36x05fn 96 11 during during IN cord-008761-b36x05fn 96 12 autumn autumn NN cord-008761-b36x05fn 96 13 and and CC cord-008761-b36x05fn 96 14 winter winter NN cord-008761-b36x05fn 96 15 periods period NNS cord-008761-b36x05fn 96 16 as as IN cord-008761-b36x05fn 96 17 a a DT cord-008761-b36x05fn 96 18 means means NN cord-008761-b36x05fn 96 19 of of IN cord-008761-b36x05fn 96 20 prophylaxis prophylaxis NN cord-008761-b36x05fn 96 21 against against IN cord-008761-b36x05fn 96 22 common common JJ cord-008761-b36x05fn 96 23 cold cold NN cord-008761-b36x05fn 96 24 . . . cord-008761-b36x05fn 97 1 However however RB cord-008761-b36x05fn 97 2 , , , cord-008761-b36x05fn 97 3 it -PRON- PRP cord-008761-b36x05fn 97 4 is be VBZ cord-008761-b36x05fn 97 5 now now RB cord-008761-b36x05fn 97 6 being be VBG cord-008761-b36x05fn 97 7 suggested suggest VBN cord-008761-b36x05fn 97 8 that that IN cord-008761-b36x05fn 97 9 such such JJ cord-008761-b36x05fn 97 10 long long JJ cord-008761-b36x05fn 97 11 - - HYPH cord-008761-b36x05fn 97 12 term term NN cord-008761-b36x05fn 97 13 instillations instillation NNS cord-008761-b36x05fn 97 14 cause cause VBP cord-008761-b36x05fn 97 15 damage damage NN cord-008761-b36x05fn 97 16 to to IN cord-008761-b36x05fn 97 17 the the DT cord-008761-b36x05fn 97 18 nasal nasal NN cord-008761-b36x05fn 97 19 mucosa mucosa JJ cord-008761-b36x05fn 97 20 . . . cord-008761-b36x05fn 98 1 Condyloma condyloma NN cord-008761-b36x05fn 98 2 accuminatum accuminatum NN cord-008761-b36x05fn 98 3 is be VBZ cord-008761-b36x05fn 98 4 amenable amenable JJ cord-008761-b36x05fn 98 5 to to IN cord-008761-b36x05fn 98 6 treatment treatment NN cord-008761-b36x05fn 98 7 with with IN cord-008761-b36x05fn 98 8 ointments ointment NNS cord-008761-b36x05fn 98 9 or or CC cord-008761-b36x05fn 98 10 gel gel NN cord-008761-b36x05fn 98 11 lies lie NNS cord-008761-b36x05fn 98 12 containing contain VBG cord-008761-b36x05fn 98 13 interferon interferon NN cord-008761-b36x05fn 98 14 ( ( -LRB- cord-008761-b36x05fn 98 15 26 26 CD cord-008761-b36x05fn 98 16 ) ) -RRB- cord-008761-b36x05fn 98 17 . . . cord-008761-b36x05fn 99 1 A a DT cord-008761-b36x05fn 99 2 problem problem NN cord-008761-b36x05fn 99 3 in in IN cord-008761-b36x05fn 99 4 interpreting interpret VBG cord-008761-b36x05fn 99 5 these these DT cord-008761-b36x05fn 99 6 results result NNS cord-008761-b36x05fn 99 7 is be VBZ cord-008761-b36x05fn 99 8 the the DT cord-008761-b36x05fn 99 9 possible possible JJ cord-008761-b36x05fn 99 10 confounding confound VBG cord-008761-b36x05fn 99 11 , , , cord-008761-b36x05fn 99 12 especially especially RB cord-008761-b36x05fn 99 13 in in IN cord-008761-b36x05fn 99 14 non non JJ cord-008761-b36x05fn 99 15 - - JJ cord-008761-b36x05fn 99 16 placebo placebo JJ cord-008761-b36x05fn 99 17 - - HYPH cord-008761-b36x05fn 99 18 controlled control VBN cord-008761-b36x05fn 99 19 trials trial NNS cord-008761-b36x05fn 99 20 , , , cord-008761-b36x05fn 99 21 of of IN cord-008761-b36x05fn 99 22 the the DT cord-008761-b36x05fn 99 23 mere mere JJ cord-008761-b36x05fn 99 24 effects effect NNS cord-008761-b36x05fn 99 25 of of IN cord-008761-b36x05fn 99 26 hygiene hygiene NN cord-008761-b36x05fn 99 27 . . . cord-008761-b36x05fn 100 1 Daily daily JJ cord-008761-b36x05fn 100 2 care care NN cord-008761-b36x05fn 100 3 of of IN cord-008761-b36x05fn 100 4 the the DT cord-008761-b36x05fn 100 5 lesions lesion NNS cord-008761-b36x05fn 100 6 may may MD cord-008761-b36x05fn 100 7 by by IN cord-008761-b36x05fn 100 8 itself -PRON- PRP cord-008761-b36x05fn 100 9 contribute contribute VB cord-008761-b36x05fn 100 10 to to IN cord-008761-b36x05fn 100 11 regression regression NN cord-008761-b36x05fn 100 12 of of IN cord-008761-b36x05fn 100 13 the the DT cord-008761-b36x05fn 100 14 condylomas condylomas NN cord-008761-b36x05fn 100 15 . . . cord-008761-b36x05fn 101 1 However however RB cord-008761-b36x05fn 101 2 , , , cord-008761-b36x05fn 101 3 the the DT cord-008761-b36x05fn 101 4 interpretation interpretation NN cord-008761-b36x05fn 101 5 that that IN cord-008761-b36x05fn 101 6 the the DT cord-008761-b36x05fn 101 7 effects effect NNS cord-008761-b36x05fn 101 8 are be VBP cord-008761-b36x05fn 101 9 largely largely RB cord-008761-b36x05fn 101 10 due due JJ cord-008761-b36x05fn 101 11 , , , cord-008761-b36x05fn 101 12 indeed indeed RB cord-008761-b36x05fn 101 13 , , , cord-008761-b36x05fn 101 14 to to IN cord-008761-b36x05fn 101 15 the the DT cord-008761-b36x05fn 101 16 action action NN cord-008761-b36x05fn 101 17 of of IN cord-008761-b36x05fn 101 18 the the DT cord-008761-b36x05fn 101 19 interferon interferon NN cord-008761-b36x05fn 101 20 is be VBZ cord-008761-b36x05fn 101 21 corroborated corroborate VBN cord-008761-b36x05fn 101 22 by by IN cord-008761-b36x05fn 101 23 the the DT cord-008761-b36x05fn 101 24 observation observation NN cord-008761-b36x05fn 101 25 that that IN cord-008761-b36x05fn 101 26 other other JJ cord-008761-b36x05fn 101 27 manifestations manifestation NNS cord-008761-b36x05fn 101 28 of of IN cord-008761-b36x05fn 101 29 HPV hpv NN cord-008761-b36x05fn 101 30 infections infection NNS cord-008761-b36x05fn 101 31 are be VBP cord-008761-b36x05fn 101 32 also also RB cord-008761-b36x05fn 101 33 amenable amenable JJ cord-008761-b36x05fn 101 34 to to IN cord-008761-b36x05fn 101 35 treatment treatment NN cord-008761-b36x05fn 101 36 with with IN cord-008761-b36x05fn 101 37 interferon interferon NN cord-008761-b36x05fn 101 38 . . . cord-008761-b36x05fn 102 1 Thus thus RB cord-008761-b36x05fn 102 2 , , , cord-008761-b36x05fn 102 3 skin skin NN cord-008761-b36x05fn 102 4 warts wart NNS cord-008761-b36x05fn 102 5 can can MD cord-008761-b36x05fn 102 6 be be VB cord-008761-b36x05fn 102 7 made make VBN cord-008761-b36x05fn 102 8 to to TO cord-008761-b36x05fn 102 9 disappear disappear VB cord-008761-b36x05fn 102 10 by by IN cord-008761-b36x05fn 102 11 repeated repeat VBN cord-008761-b36x05fn 102 12 injections injection NNS cord-008761-b36x05fn 102 13 of of IN cord-008761-b36x05fn 102 14 fibroblast fibroblast NN cord-008761-b36x05fn 103 1 interferon interferon NNP cord-008761-b36x05fn 103 2 in in IN cord-008761-b36x05fn 103 3 the the DT cord-008761-b36x05fn 103 4 perilesional perilesional JJ cord-008761-b36x05fn 103 5 skin skin NN cord-008761-b36x05fn 103 6 ( ( -LRB- cord-008761-b36x05fn 103 7 27 27 CD cord-008761-b36x05fn 103 8 ) ) -RRB- cord-008761-b36x05fn 103 9 . . . cord-008761-b36x05fn 104 1 Beginning begin VBG cord-008761-b36x05fn 104 2 or or CC cord-008761-b36x05fn 104 3 established establish VBN cord-008761-b36x05fn 104 4 acute acute JJ cord-008761-b36x05fn 104 5 ( ( -LRB- cord-008761-b36x05fn 104 6 primary primary JJ cord-008761-b36x05fn 104 7 or or CC cord-008761-b36x05fn 104 8 recurrent recurrent JJ cord-008761-b36x05fn 104 9 ) ) -RRB- cord-008761-b36x05fn 104 10 infections infection NNS cord-008761-b36x05fn 104 11 . . . cord-008761-b36x05fn 105 1 Systemic systemic JJ cord-008761-b36x05fn 105 2 administration administration NN cord-008761-b36x05fn 105 3 of of IN cord-008761-b36x05fn 105 4 interferons interferon NNS cord-008761-b36x05fn 105 5 ( ( -LRB- cord-008761-b36x05fn 105 6 a a LS cord-008761-b36x05fn 105 7 - - : cord-008761-b36x05fn 105 8 or or CC cord-008761-b36x05fn 105 9 8-type 8-type CD cord-008761-b36x05fn 105 10 ) ) -RRB- cord-008761-b36x05fn 105 11 has have VBZ cord-008761-b36x05fn 105 12 been be VBN cord-008761-b36x05fn 105 13 found find VBN cord-008761-b36x05fn 105 14 to to TO cord-008761-b36x05fn 105 15 favorably favorably RB cord-008761-b36x05fn 105 16 affect affect VB cord-008761-b36x05fn 105 17 the the DT cord-008761-b36x05fn 105 18 course course NN cord-008761-b36x05fn 105 19 of of IN cord-008761-b36x05fn 105 20 a a DT cord-008761-b36x05fn 105 21 number number NN cord-008761-b36x05fn 105 22 of of IN cord-008761-b36x05fn 105 23 acute acute JJ cord-008761-b36x05fn 105 24 ( ( -LRB- cord-008761-b36x05fn 105 25 prima prima FW cord-008761-b36x05fn 105 26 ry ry NN cord-008761-b36x05fn 105 27 or or CC cord-008761-b36x05fn 105 28 recurrent recurrent JJ cord-008761-b36x05fn 105 29 ) ) -RRB- cord-008761-b36x05fn 105 30 virus virus NN cord-008761-b36x05fn 105 31 infections infection NNS cord-008761-b36x05fn 105 32 : : : cord-008761-b36x05fn 105 33 varicella varicella NN cord-008761-b36x05fn 105 34 in in IN cord-008761-b36x05fn 105 35 imrnunocompromised imrnunocompromise VBN cord-008761-b36x05fn 105 36 patients patient NNS cord-008761-b36x05fn 105 37 ( ( -LRB- cord-008761-b36x05fn 105 38 28 28 CD cord-008761-b36x05fn 105 39 ) ) -RRB- cord-008761-b36x05fn 105 40 , , , cord-008761-b36x05fn 105 41 zoster zoster NN cord-008761-b36x05fn 105 42 in in IN cord-008761-b36x05fn 105 43 cancer cancer NN cord-008761-b36x05fn 105 44 patients patient NNS cord-008761-b36x05fn 105 45 ( ( -LRB- cord-008761-b36x05fn 105 46 29 29 CD cord-008761-b36x05fn 105 47 ) ) -RRB- cord-008761-b36x05fn 105 48 . . . cord-008761-b36x05fn 106 1 The the DT cord-008761-b36x05fn 106 2 practical practical JJ cord-008761-b36x05fn 106 3 importance importance NN cord-008761-b36x05fn 106 4 of of IN cord-008761-b36x05fn 106 5 these these DT cord-008761-b36x05fn 106 6 observations observation NNS cord-008761-b36x05fn 106 7 is be VBZ cord-008761-b36x05fn 106 8 rather rather RB cord-008761-b36x05fn 106 9 minor minor JJ cord-008761-b36x05fn 106 10 , , , cord-008761-b36x05fn 106 11 in in IN cord-008761-b36x05fn 106 12 that that DT cord-008761-b36x05fn 106 13 beginning beginning NN cord-008761-b36x05fn 106 14 or or CC cord-008761-b36x05fn 106 15 established establish VBN cord-008761-b36x05fn 106 16 HSV HSV NNP cord-008761-b36x05fn 106 17 and and CC cord-008761-b36x05fn 106 18 VZV VZV NNP cord-008761-b36x05fn 106 19 infections infection NNS cord-008761-b36x05fn 106 20 can can MD cord-008761-b36x05fn 106 21 now now RB cord-008761-b36x05fn 106 22 effectively effectively RB cord-008761-b36x05fn 106 23 be be VB cord-008761-b36x05fn 106 24 treated treat VBN cord-008761-b36x05fn 106 25 with with IN cord-008761-b36x05fn 106 26 nucleoside nucleoside JJ cord-008761-b36x05fn 106 27 analogs analog NNS cord-008761-b36x05fn 106 28 . . . cord-008761-b36x05fn 107 1 Prevention prevention NN cord-008761-b36x05fn 107 2 of of IN cord-008761-b36x05fn 107 3 acute acute JJ cord-008761-b36x05fn 107 4 infections infection NNS cord-008761-b36x05fn 107 5 . . . cord-008761-b36x05fn 108 1 Systemic systemic JJ cord-008761-b36x05fn 108 2 treatment treatment NN cord-008761-b36x05fn 108 3 with with IN cord-008761-b36x05fn 108 4 interferon interferon NN cord-008761-b36x05fn 108 5 can can MD cord-008761-b36x05fn 108 6 prevent prevent VB cord-008761-b36x05fn 108 7 herpes herpes NN cord-008761-b36x05fn 108 8 recurrence recurrence NN cord-008761-b36x05fn 108 9 after after IN cord-008761-b36x05fn 108 10 surgical surgical JJ cord-008761-b36x05fn 108 11 interventions intervention NNS cord-008761-b36x05fn 108 12 on on IN cord-008761-b36x05fn 108 13 the the DT cord-008761-b36x05fn 108 14 trigeminal trigeminal JJ cord-008761-b36x05fn 108 15 nerve nerve NN cord-008761-b36x05fn 108 16 ganglion ganglion NN cord-008761-b36x05fn 108 17 ( ( -LRB- cord-008761-b36x05fn 108 18 operation operation NN cord-008761-b36x05fn 108 19 for for IN cord-008761-b36x05fn 108 20 " " `` cord-008761-b36x05fn 108 21 tic tic NNP cord-008761-b36x05fn 108 22 douloureux douloureux FW cord-008761-b36x05fn 108 23 " " '' cord-008761-b36x05fn 108 24 ) ) -RRB- cord-008761-b36x05fn 109 1 ( ( -LRB- cord-008761-b36x05fn 109 2 30 30 CD cord-008761-b36x05fn 109 3 ) ) -RRB- cord-008761-b36x05fn 109 4 . . . cord-008761-b36x05fn 110 1 Interferon interferon NN cord-008761-b36x05fn 110 2 therapy therapy NN cord-008761-b36x05fn 110 3 has have VBZ cord-008761-b36x05fn 110 4 a a DT cord-008761-b36x05fn 110 5 l l NN cord-008761-b36x05fn 110 6 so so RB cord-008761-b36x05fn 110 7 been be VBN cord-008761-b36x05fn 110 8 considered consider VBN cord-008761-b36x05fn 110 9 as as IN cord-008761-b36x05fn 110 10 a a DT cord-008761-b36x05fn 110 11 possible possible JJ cord-008761-b36x05fn 110 12 means mean VBZ cord-008761-b36x05fn 110 13 to to TO cord-008761-b36x05fn 110 14 cope cope VB cord-008761-b36x05fn 110 15 with with IN cord-008761-b36x05fn 110 16 the the DT cord-008761-b36x05fn 110 17 increased increase VBN cord-008761-b36x05fn 110 18 incidence incidence NN cord-008761-b36x05fn 110 19 and and CC cord-008761-b36x05fn 110 20 severity severity NN cord-008761-b36x05fn 110 21 of of IN cord-008761-b36x05fn 110 22 viral viral JJ cord-008761-b36x05fn 110 23 infections infection NNS cord-008761-b36x05fn 110 24 in in IN cord-008761-b36x05fn 110 25 renal renal JJ cord-008761-b36x05fn 110 26 transplant transplant NN cord-008761-b36x05fn 110 27 patients patient NNS cord-008761-b36x05fn 110 28 ( ( -LRB- cord-008761-b36x05fn 110 29 31 31 CD cord-008761-b36x05fn 110 30 ) ) -RRB- cord-008761-b36x05fn 110 31 ; ; : cord-008761-b36x05fn 110 32 it -PRON- PRP cord-008761-b36x05fn 110 33 appears appear VBZ cord-008761-b36x05fn 110 34 that that IN cord-008761-b36x05fn 110 35 interferon interferon NN cord-008761-b36x05fn 110 36 therapy therapy NN cord-008761-b36x05fn 110 37 reduces reduce VBZ cord-008761-b36x05fn 110 38 virus virus NN cord-008761-b36x05fn 110 39 - - HYPH cord-008761-b36x05fn 110 40 shedding shed VBG cord-008761-b36x05fn 110 41 as as RB cord-008761-b36x05fn 110 42 well well RB cord-008761-b36x05fn 110 43 as as IN cord-008761-b36x05fn 110 44 the the DT cord-008761-b36x05fn 110 45 severity severity NN cord-008761-b36x05fn 110 46 of of IN cord-008761-b36x05fn 110 47 symptoms symptom NNS cord-008761-b36x05fn 110 48 of of IN cord-008761-b36x05fn 110 49 CMV CMV NNP cord-008761-b36x05fn 110 50 infections infection NNS cord-008761-b36x05fn 110 51 . . . cord-008761-b36x05fn 111 1 Chronic chronic JJ cord-008761-b36x05fn 111 2 active active JJ cord-008761-b36x05fn 111 3 virus virus NN cord-008761-b36x05fn 111 4 infections infection NNS cord-008761-b36x05fn 111 5 . . . cord-008761-b36x05fn 112 1 The the DT cord-008761-b36x05fn 112 2 following follow VBG cord-008761-b36x05fn 112 3 chronic chronic JJ cord-008761-b36x05fn 112 4 active active JJ cord-008761-b36x05fn 112 5 virus virus NN cord-008761-b36x05fn 112 6 infections infection NNS cord-008761-b36x05fn 112 7 are be VBP cord-008761-b36x05fn 112 8 currently currently RB cord-008761-b36x05fn 112 9 investigated investigate VBN cord-008761-b36x05fn 112 10 as as IN cord-008761-b36x05fn 112 11 pos pos NNP cord-008761-b36x05fn 112 12 s s NNP cord-008761-b36x05fn 112 13 ible ible JJ cord-008761-b36x05fn 112 14 targets target NNS cord-008761-b36x05fn 112 15 for for IN cord-008761-b36x05fn 112 16 systemic systemic JJ cord-008761-b36x05fn 112 17 interferon interferon NN cord-008761-b36x05fn 112 18 therapy therapy NN cord-008761-b36x05fn 112 19 : : : cord-008761-b36x05fn 112 20 persistent persistent JJ cord-008761-b36x05fn 112 21 infections infection NNS cord-008761-b36x05fn 112 22 with with IN cord-008761-b36x05fn 112 23 HB HB NNP cord-008761-b36x05fn 112 24 virus virus NN cord-008761-b36x05fn 112 25 , , , cord-008761-b36x05fn 112 26 chronic chronic JJ cord-008761-b36x05fn 112 27 infections infection NNS cord-008761-b36x05fn 112 28 with with IN cord-008761-b36x05fn 112 29 HPV hpv NN cord-008761-b36x05fn 112 30 ( ( -LRB- cord-008761-b36x05fn 112 31 warts wart NNS cord-008761-b36x05fn 112 32 and and CC cord-008761-b36x05fn 112 33 wartlike wartlike JJ cord-008761-b36x05fn 112 34 diseases disease NNS cord-008761-b36x05fn 112 35 ) ) -RRB- cord-008761-b36x05fn 112 36 , , , cord-008761-b36x05fn 112 37 chronic chronic JJ cord-008761-b36x05fn 112 38 infection infection NN cord-008761-b36x05fn 112 39 with with IN cord-008761-b36x05fn 112 40 leukemia leukemia NN cord-008761-b36x05fn 112 41 viruses virus NNS cord-008761-b36x05fn 112 42 , , , cord-008761-b36x05fn 112 43 e.g. e.g. DT cord-008761-b36x05fn 112 44 HTLV HTLV NNP cord-008761-b36x05fn 112 45 . . . cord-008761-b36x05fn 113 1 The the DT cord-008761-b36x05fn 113 2 effects effect NNS cord-008761-b36x05fn 113 3 of of IN cord-008761-b36x05fn 113 4 interferon interferon NN cord-008761-b36x05fn 113 5 therapy therapy NN cord-008761-b36x05fn 113 6 on on IN cord-008761-b36x05fn 113 7 persistence persistence NN cord-008761-b36x05fn 113 8 of of IN cord-008761-b36x05fn 113 9 HB HB NNP cord-008761-b36x05fn 113 10 virus virus NN cord-008761-b36x05fn 113 11 has have VBZ cord-008761-b36x05fn 113 12 rather rather RB cord-008761-b36x05fn 113 13 extensively extensively RB cord-008761-b36x05fn 113 14 been be VBN cord-008761-b36x05fn 113 15 investigated investigate VBN cord-008761-b36x05fn 113 16 . . . cord-008761-b36x05fn 114 1 In in IN cord-008761-b36x05fn 114 2 some some DT cord-008761-b36x05fn 114 3 patients patient NNS cord-008761-b36x05fn 114 4 transient transient JJ cord-008761-b36x05fn 114 5 and and CC cord-008761-b36x05fn 114 6 sometimes sometimes RB cord-008761-b36x05fn 114 7 definitive definitive JJ cord-008761-b36x05fn 114 8 disappearance disappearance NN cord-008761-b36x05fn 114 9 of of IN cord-008761-b36x05fn 114 10 viral viral JJ cord-008761-b36x05fn 114 11 infectivity infectivity NN cord-008761-b36x05fn 114 12 markers marker NNS cord-008761-b36x05fn 114 13 , , , cord-008761-b36x05fn 114 14 accompanied accompany VBN cord-008761-b36x05fn 114 15 by by IN cord-008761-b36x05fn 114 16 clinical clinical JJ cord-008761-b36x05fn 114 17 improvements improvement NNS cord-008761-b36x05fn 114 18 , , , cord-008761-b36x05fn 114 19 were be VBD cord-008761-b36x05fn 114 20 seen see VBN cord-008761-b36x05fn 114 21 . . . cord-008761-b36x05fn 115 1 It -PRON- PRP cord-008761-b36x05fn 115 2 is be VBZ cord-008761-b36x05fn 115 3 difficult difficult JJ cord-008761-b36x05fn 115 4 , , , cord-008761-b36x05fn 115 5 however however RB cord-008761-b36x05fn 115 6 , , , cord-008761-b36x05fn 115 7 to to TO cord-008761-b36x05fn 115 8 certify certify VB cord-008761-b36x05fn 115 9 tha tha NNP cord-008761-b36x05fn 115 10 t t NN cord-008761-b36x05fn 115 11 these these DT cord-008761-b36x05fn 115 12 were be VBD cord-008761-b36x05fn 115 13 not not RB cord-008761-b36x05fn 115 14 spontaneous spontaneous JJ cord-008761-b36x05fn 115 15 cures cure NNS cord-008761-b36x05fn 115 16 or or CC cord-008761-b36x05fn 115 17 placeboeffects placeboeffect NNS cord-008761-b36x05fn 115 18 ( ( -LRB- cord-008761-b36x05fn 115 19 32 32 CD cord-008761-b36x05fn 115 20 ) ) -RRB- cord-008761-b36x05fn 115 21 . . . cord-008761-b36x05fn 116 1 The the DT cord-008761-b36x05fn 116 2 need need NN cord-008761-b36x05fn 116 3 for for IN cord-008761-b36x05fn 116 4 properly properly RB cord-008761-b36x05fn 116 5 controlled control VBN cord-008761-b36x05fn 116 6 trials trial NNS cord-008761-b36x05fn 116 7 , , , cord-008761-b36x05fn 116 8 expressed express VBD cord-008761-b36x05fn 116 9 early early RB cord-008761-b36x05fn 116 10 on on RB cord-008761-b36x05fn 116 11 by by IN cord-008761-b36x05fn 116 12 several several JJ cord-008761-b36x05fn 116 13 investigators investigator NNS cord-008761-b36x05fn 116 14 , , , cord-008761-b36x05fn 116 15 has have VBZ cord-008761-b36x05fn 116 16 at at IN cord-008761-b36x05fn 116 17 this this DT cord-008761-b36x05fn 116 18 time time NN cord-008761-b36x05fn 116 19 still still RB cord-008761-b36x05fn 116 20 not not RB cord-008761-b36x05fn 116 21 been be VBN cord-008761-b36x05fn 116 22 satisfied satisfied JJ cord-008761-b36x05fn 116 23 . . . cord-008761-b36x05fn 117 1 Therefore therefore RB cord-008761-b36x05fn 117 2 it -PRON- PRP cord-008761-b36x05fn 117 3 remains remain VBZ cord-008761-b36x05fn 117 4 impossible impossible JJ cord-008761-b36x05fn 117 5 to to TO cord-008761-b36x05fn 117 6 even even RB cord-008761-b36x05fn 117 7 approximately approximately RB cord-008761-b36x05fn 117 8 assess assess VB cord-008761-b36x05fn 117 9 the the DT cord-008761-b36x05fn 117 10 therapeutic therapeutic JJ cord-008761-b36x05fn 117 11 potential potential NN cord-008761-b36x05fn 117 12 of of IN cord-008761-b36x05fn 117 13 interferon interferon NN cord-008761-b36x05fn 117 14 in in IN cord-008761-b36x05fn 117 15 chronic chronic JJ cord-008761-b36x05fn 117 16 hepatitis hepatitis NN cord-008761-b36x05fn 117 17 . . . cord-008761-b36x05fn 118 1 The the DT cord-008761-b36x05fn 118 2 situation situation NN cord-008761-b36x05fn 118 3 with with IN cord-008761-b36x05fn 118 4 chronic chronic JJ cord-008761-b36x05fn 118 5 HPV HPV NNP cord-008761-b36x05fn 118 6 infections infection NNS cord-008761-b36x05fn 118 7 is be VBZ cord-008761-b36x05fn 118 8 quite quite RB cord-008761-b36x05fn 118 9 different different JJ cord-008761-b36x05fn 118 10 . . . cord-008761-b36x05fn 119 1 Thus thus RB cord-008761-b36x05fn 119 2 it -PRON- PRP cord-008761-b36x05fn 119 3 is be VBZ cord-008761-b36x05fn 119 4 now now RB cord-008761-b36x05fn 119 5 generally generally RB cord-008761-b36x05fn 119 6 recognized recognize VBN cord-008761-b36x05fn 119 7 that that IN cord-008761-b36x05fn 119 8 juvenile juvenile JJ cord-008761-b36x05fn 119 9 laryngeal laryngeal NN cord-008761-b36x05fn 119 10 papilloma papilloma NN cord-008761-b36x05fn 119 11 , , , cord-008761-b36x05fn 119 12 a a DT cord-008761-b36x05fn 119 13 rather rather RB cord-008761-b36x05fn 119 14 rare rare JJ cord-008761-b36x05fn 119 15 but but CC cord-008761-b36x05fn 119 16 serious serious JJ cord-008761-b36x05fn 119 17 complication complication NN cord-008761-b36x05fn 119 18 of of IN cord-008761-b36x05fn 119 19 infection infection NN cord-008761-b36x05fn 119 20 with with IN cord-008761-b36x05fn 119 21 certain certain JJ cord-008761-b36x05fn 119 22 HPV hpv NN cord-008761-b36x05fn 119 23 types type NNS cord-008761-b36x05fn 119 24 , , , cord-008761-b36x05fn 119 25 is be VBZ cord-008761-b36x05fn 119 26 quite quite RB cord-008761-b36x05fn 119 27 amenable amenable JJ cord-008761-b36x05fn 119 28 to to TO cord-008761-b36x05fn 119 29 control control NN cord-008761-b36x05fn 119 30 by by IN cord-008761-b36x05fn 119 31 therapy therapy NN cord-008761-b36x05fn 119 32 with with IN cord-008761-b36x05fn 119 33 various various JJ cord-008761-b36x05fn 119 34 preparations preparation NNS cord-008761-b36x05fn 119 35 of of IN cord-008761-b36x05fn 119 36 HuIFN HuIFN NNP cord-008761-b36x05fn 119 37 - - : cord-008761-b36x05fn 119 38 a a NN cord-008761-b36x05fn 119 39 ( ( -LRB- cord-008761-b36x05fn 119 40 33 33 CD cord-008761-b36x05fn 119 41 ) ) -RRB- cord-008761-b36x05fn 119 42 . . . cord-008761-b36x05fn 120 1 The the DT cord-008761-b36x05fn 120 2 therapy therapy NN cord-008761-b36x05fn 120 3 has have VBZ cord-008761-b36x05fn 120 4 to to TO cord-008761-b36x05fn 120 5 be be VB cord-008761-b36x05fn 120 6 given give VBN cord-008761-b36x05fn 120 7 continuously continuously RB cord-008761-b36x05fn 120 8 for for IN cord-008761-b36x05fn 120 9 months month NNS cord-008761-b36x05fn 120 10 before before IN cord-008761-b36x05fn 120 11 recurrence recurrence NN cord-008761-b36x05fn 120 12 of of IN cord-008761-b36x05fn 120 13 the the DT cord-008761-b36x05fn 120 14 laryngea laryngea NNS cord-008761-b36x05fn 120 15 l l NNP cord-008761-b36x05fn 120 16 warts wart NNS cord-008761-b36x05fn 120 17 is be VBZ cord-008761-b36x05fn 120 18 brought bring VBN cord-008761-b36x05fn 120 19 under under IN cord-008761-b36x05fn 120 20 control control NN cord-008761-b36x05fn 120 21 . . . cord-008761-b36x05fn 121 1 Arrest arrest NN cord-008761-b36x05fn 121 2 of of IN cord-008761-b36x05fn 121 3 treatment treatment NN cord-008761-b36x05fn 121 4 entails entail VBZ cord-008761-b36x05fn 121 5 recurrence recurrence NN cord-008761-b36x05fn 121 6 , , , cord-008761-b36x05fn 121 7 but but CC cord-008761-b36x05fn 121 8 it -PRON- PRP cord-008761-b36x05fn 121 9 is be VBZ cord-008761-b36x05fn 121 10 hoped hope VBN cord-008761-b36x05fn 121 11 that that IN cord-008761-b36x05fn 121 12 suitable suitable JJ cord-008761-b36x05fn 121 13 low low JJ cord-008761-b36x05fn 121 14 - - HYPH cord-008761-b36x05fn 121 15 dose dose NN cord-008761-b36x05fn 121 16 maintenance maintenance NN cord-008761-b36x05fn 121 17 treatments treatment NNS cord-008761-b36x05fn 121 18 can can MD cord-008761-b36x05fn 121 19 be be VB cord-008761-b36x05fn 121 20 designed design VBN cord-008761-b36x05fn 121 21 , , , cord-008761-b36x05fn 121 22 by by IN cord-008761-b36x05fn 121 23 which which WDT cord-008761-b36x05fn 121 24 protections protection NNS cord-008761-b36x05fn 121 25 can can MD cord-008761-b36x05fn 121 26 be be VB cord-008761-b36x05fn 121 27 prolonged prolong VBN cord-008761-b36x05fn 121 28 to to IN cord-008761-b36x05fn 121 29 the the DT cord-008761-b36x05fn 121 30 age age NN cord-008761-b36x05fn 121 31 where where WRB cord-008761-b36x05fn 121 32 the the DT cord-008761-b36x05fn 121 33 papillomas papilloma NNS cord-008761-b36x05fn 121 34 tend tend VBP cord-008761-b36x05fn 121 35 to to TO cord-008761-b36x05fn 121 36 regress regress VB cord-008761-b36x05fn 121 37 spontaneously spontaneously RB cord-008761-b36x05fn 121 38 . . . cord-008761-b36x05fn 122 1 Retroviruses retrovirus NNS cord-008761-b36x05fn 122 2 have have VBP cord-008761-b36x05fn 122 3 only only RB cord-008761-b36x05fn 122 4 recently recently RB cord-008761-b36x05fn 122 5 been be VBN cord-008761-b36x05fn 122 6 implicated implicate VBN cord-008761-b36x05fn 122 7 as as IN cord-008761-b36x05fn 122 8 etiologic etiologic NNP cord-008761-b36x05fn 122 9 fa fa NNP cord-008761-b36x05fn 122 10 c c NN cord-008761-b36x05fn 122 11 tors tor NNS cord-008761-b36x05fn 122 12 in in IN cord-008761-b36x05fn 122 13 human human JJ cord-008761-b36x05fn 122 14 diseases disease NNS cord-008761-b36x05fn 122 15 , , , cord-008761-b36x05fn 122 16 namely namely RB cord-008761-b36x05fn 122 17 human human JJ cord-008761-b36x05fn 122 18 T t NN cord-008761-b36x05fn 122 19 - - HYPH cord-008761-b36x05fn 122 20 cell cell NN cord-008761-b36x05fn 122 21 leukemia leukemia NN cord-008761-b36x05fn 122 22 ( ( -LRB- cord-008761-b36x05fn 122 23 HTLV HTLV NNP cord-008761-b36x05fn 122 24 - - HYPH cord-008761-b36x05fn 122 25 I i NN cord-008761-b36x05fn 122 26 and and CC cord-008761-b36x05fn 122 27 -II -II , cord-008761-b36x05fn 122 28 ) ) -RRB- cord-008761-b36x05fn 122 29 and and CC cord-008761-b36x05fn 122 30 AIDS AIDS NNP cord-008761-b36x05fn 122 31 ( ( -LRB- cord-008761-b36x05fn 122 32 LAV LAV NNP cord-008761-b36x05fn 122 33 or or CC cord-008761-b36x05fn 122 34 HTLV HTLV NNP cord-008761-b36x05fn 122 35 - - HYPH cord-008761-b36x05fn 122 36 III III NNP cord-008761-b36x05fn 122 37 ) ) -RRB- cord-008761-b36x05fn 122 38 . . . cord-008761-b36x05fn 123 1 Interferon interferon NN cord-008761-b36x05fn 123 2 therapy therapy NN cord-008761-b36x05fn 123 3 has have VBZ cord-008761-b36x05fn 123 4 already already RB cord-008761-b36x05fn 123 5 been be VBN cord-008761-b36x05fn 123 6 investigated investigate VBN cord-008761-b36x05fn 123 7 as as IN cord-008761-b36x05fn 123 8 a a DT cord-008761-b36x05fn 123 9 means means NN cord-008761-b36x05fn 123 10 to to TO cord-008761-b36x05fn 123 11 control control VB cord-008761-b36x05fn 123 12 AIDS AIDS NNP cord-008761-b36x05fn 123 13 and and CC cord-008761-b36x05fn 123 14 AIDS AIDS NNP cord-008761-b36x05fn 123 15 - - HYPH cord-008761-b36x05fn 123 16 associated associate VBN cord-008761-b36x05fn 123 17 malignancies malignancy NNS cord-008761-b36x05fn 123 18 ( ( -LRB- cord-008761-b36x05fn 123 19 Kaposi Kaposi NNP cord-008761-b36x05fn 123 20 sarcoma sarcoma NN cord-008761-b36x05fn 123 21 ) ) -RRB- cord-008761-b36x05fn 123 22 , , , cord-008761-b36x05fn 123 23 and and CC cord-008761-b36x05fn 123 24 some some DT cord-008761-b36x05fn 123 25 encouraging encouraging JJ cord-008761-b36x05fn 123 26 results result NNS cord-008761-b36x05fn 123 27 have have VBP cord-008761-b36x05fn 123 28 been be VBN cord-008761-b36x05fn 123 29 reported report VBN cord-008761-b36x05fn 123 30 in in IN cord-008761-b36x05fn 123 31 that that IN cord-008761-b36x05fn 123 32 the the DT cord-008761-b36x05fn 123 33 symptoms symptom NNS cord-008761-b36x05fn 123 34 of of IN cord-008761-b36x05fn 123 35 the the DT cord-008761-b36x05fn 123 36 disease disease NN cord-008761-b36x05fn 123 37 can can MD cord-008761-b36x05fn 123 38 in in IN cord-008761-b36x05fn 123 39 some some DT cord-008761-b36x05fn 123 40 patients patient NNS cord-008761-b36x05fn 123 41 be be VB cord-008761-b36x05fn 123 42 alleviated alleviate VBN cord-008761-b36x05fn 123 43 ( ( -LRB- cord-008761-b36x05fn 123 44 34 34 CD cord-008761-b36x05fn 123 45 ) ) -RRB- cord-008761-b36x05fn 123 46 . . . cord-008761-b36x05fn 124 1 A a DT cord-008761-b36x05fn 124 2 cure cure NN cord-008761-b36x05fn 124 3 of of IN cord-008761-b36x05fn 124 4 AIDS AIDS NNP cord-008761-b36x05fn 124 5 however however RB cord-008761-b36x05fn 124 6 , , , cord-008761-b36x05fn 124 7 has have VBZ cord-008761-b36x05fn 124 8 not not RB cord-008761-b36x05fn 124 9 been be VBN cord-008761-b36x05fn 124 10 seen see VBN cord-008761-b36x05fn 124 11 . . . cord-008761-b36x05fn 125 1 Mechanisms mechanism NNS cord-008761-b36x05fn 125 2 of of IN cord-008761-b36x05fn 125 3 Production Production NNP cord-008761-b36x05fn 125 4 and and CC cord-008761-b36x05fn 125 5 Action Action NNP cord-008761-b36x05fn 125 6 Mechanisms Mechanisms NNPS cord-008761-b36x05fn 125 7 of of IN cord-008761-b36x05fn 125 8 Production Production NNP cord-008761-b36x05fn 125 9 and and CC cord-008761-b36x05fn 125 10 Action Action NNP cord-008761-b36x05fn 125 11 Proceedings Proceedings NNP cord-008761-b36x05fn 125 12 of of IN cord-008761-b36x05fn 125 13 Symposium Symposium NNP cord-008761-b36x05fn 125 14 on on IN cord-008761-b36x05fn 125 15 Clinical Clinical NNP cord-008761-b36x05fn 125 16 Use Use NNP cord-008761-b36x05fn 125 17 of of IN cord-008761-b36x05fn 125 18 Interferon Interferon NNP