id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312688-12san3m7	Martin, Baptiste	Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry	2016-09-14		.txt	text/plain	10226	530	50	title: Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry After replication of the viral genome and RNA transcription, nascent viral particles are assembled in a process mediated by the matrix protein VP40, and virus budding occurs at the cell surface membrane in a process that involves hijacking the host ESCRT machinery (Hartlieb and Weissenhorn, 2006; Noda et al., 2006) . However, no direct interaction between both molecules has been demonstrated yet, and recent studies suggest that a 5 b 1 -integrin is not required for GP-mediated binding of internalization, but rather is a positive regulator of cathepsins, which play an important role in processing GP 1 into its fusion-competent form within the endosomes of infected cells (Schornberg et al., 2009) . After attachment mediated by interaction between the filovirus surface protein GP 1,2 (PDB: 3CSY) and various attachment factors, the complex is internalized and routed to the endosome, where GP 1,2 is processed to trigger fusion of viral and host membranes.	./cache/cord-312688-12san3m7.txt	./txt/cord-312688-12san3m7.txt