id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-310469-v4p01rze	Livonesi, Márcia Cristina	In vitro and in vivo studies of the Interferon-alpha action on distinct Orthobunyavirus	2007-02-28		.txt	text/plain	4271	244	60	Thus, in an effort to characterize antiviral agents that could attenuate infections caused by OROV, CARV, GMAV, GROV and TCMV, we tested the in vitro and in vivo actions of IFN-␣ on these viruses. However, treatment of CARV-, GMAV-or TCMV-infected mice with IFN-␣A did not result in an increase in survival or prolongation of the mean time to death and did not prevent virus replication in the brain of animals (Table 2 and Fig. 3, respectively) . Treatment with IFN-␣A initiated 24 h after mice infection by GROV was unable to inhibit either the death of animals or the viral replication in the brain (Table 3 and Fig. 5 , respectively). In vitro and in vivo results showed that IFN-␣ was able to prevent viral replication in a limited manner, exerting antiviral effect only when administrated early and in high doses, suggesting that OROV, CARV, GMAV, GROV and TCMV present some escape mechanism from antiviral actions of the IFN-␣.	./cache/cord-310469-v4p01rze.txt	./txt/cord-310469-v4p01rze.txt