id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-295470-mua0qvst	Cui, Zhanding	Nitazoxanide Protects Cats from Feline Calicivirus Infection and Acts Synergistically with Mizoribine in vitro	2020-06-21		.txt	text/plain	3805	230	63	In this study, we showed that both nitazoxanide and mizoribine had antiviral activity in F81 cells infected with different strains of FCV and also demonstrated a synergistic effect between the two drugs. (C and D) Virus TCID 50 values were calculated to determine the combined effect of different concentrations of NTZ (0-2.5 μM) and MZR (0-20 μM) on FCV. NTZ and MZR not only had antiviral efficacy against the FCV CH-JL2 strain, but the TCID 50 values of the CH-JL1, CH-JL3, CH-JL4 and CH-SH strains were also significantly different after drug treatment (p < 0.0332) (Figure 2A ). After oral NTZ treatment, either on -1 dpi or 3 dpi, levels of FCV in the trachea and lungs were significantly lower than in the control group (p < 0.0002) ( Figure 4F ). NTZ was shown to reduce viral load in the trachea and lungs and still had a therapeutic effect on FCV-infected cats when administered at 3 dpi.	./cache/cord-295470-mua0qvst.txt	./txt/cord-295470-mua0qvst.txt