id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-286103-cgky6ar6	Otaki, Momoko	Inhibition of measles virus and subacute sclerosing panencephalitis virus by RNA interference	2006-02-13		.txt	text/plain	3538	228	56	In this study, we adopted RNA interference (RNAi) strategy and examined whether small interfering RNAs (siRNAs) can be used to inhibit replication of MeV and SSPE virus. We report here that siRNAs targeted against L mRNA of MeV, either synthetic siRNAs or those generated by pcPUR + U6i-based expression plasmids, effectively and specifically inhibited replication of both MeV and SSPE virus without exhibiting any cytotoxic effect. We report here that siRNAs targeted against L mRNA of MeV, either synthetic ones or those generated by pcPUR + U6i-based expression plasmids, effectively inhibit replication of both MeV and SSPE virus. Indeed, we demonstrated in the present study that siRNAs targeted against selected portions of L mRNA of MeV, especially MV-L2 -L4 and -L5, either synthetic siRNAs or those expressed by pcPUR + U6i-based plasmids, effectively inhibited replication of both MeV and SSPE virus (Figs.	./cache/cord-286103-cgky6ar6.txt	./txt/cord-286103-cgky6ar6.txt