id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-285505-8norumv6	Vere Hodge, R. Anthony	Meeting report: 27th International conference on antiviral research, in Raleigh, NC, USA	2014-09-16		.txt	text/plain	10276	566	58	The focus of John's presentation was on the research conducted in his own and his collaborators' laboratories that ultimately led to the invention of three compounds which were discovered to have antiviral activity against human cytomegalovirus (HCMV) and which later entered clinical trials: BDCRB pyranoside (GW275175X) (Phase I), maribavir (Phases I, II and III) and cyclopropavir (Phase I). In monotherapy studies after oral dosing with TDF (300 mg) and TAF (25 mg), the plasma TFV AUC is reduced from 1920 to 268 ng.h/ml respectively whereas the reduction in HIV load from baseline is improved, from log 10 0.97 to log 10 1.46 copies/ml, respectively, reflecting the more efficient delivery of TAF to target cells and tissues. David Margolis, University of North Carolina, NC, USA In HIV-infected patients, there is a long-lasting reservoir of HIV in the form of integrated viral DNA in resting CD4+ memory cells of the host immune system.	./cache/cord-285505-8norumv6.txt	./txt/cord-285505-8norumv6.txt