id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-281069-m638nyt0	Hong, Wei	Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1	2013-12-04		.txt	text/plain	5121	283	55	Both Hp1036 and Hp1239 peptides exhibited potent virucidal activities against HSV-1 (EC(50) = 0.43 ± 0.09 and 0.41 ± 0.06 μM, respectively) and effective inhibitory effects when added at the viral attachment (EC(50) = 2.87 ± 0.16 and 5.73 ± 0.61 μM, respectively), entry (EC(50) = 4.29 ± 0.35 and 4.32 ± 0.47 μM, respectively) and postentry (EC(50) = 7.86 ± 0.80 and 8.41 ± 0.73 μM, respectively) steps. An extended peptide from bovine, indolicidin, showed a direct inactivation effect on cell-free HSV-1 virons by targeting viral membrane/ glycoprotein (Albiol Matanic and Castilla, 2004 Natural AMPs from scorpion venoms have attracted much attention due to their anti-viral bioactivities. To determine whether Hp1036 and Hp1239 could inhibit HSV-1 infection or replication in Vero cells, 10 lM of each peptide was added to the virus or cells at different times relative to incubation (Fig. 3A) . Various concentrations of peptides were added to Vero cells 1 h before HSV-1 infection and the inhibitory effects were determined by plaque assay.	./cache/cord-281069-m638nyt0.txt	./txt/cord-281069-m638nyt0.txt