id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275624-o5545c1x	Tai, Wanbo	Identification of SARS-CoV RBD-targeting monoclonal antibodies with cross-reactive or neutralizing activity against SARS-CoV-2	2020-05-13		.txt	text/plain	1611	114	69	Here, we constructed a series of SARS-CoV RBD mutant proteins based on the 176 interaction between the RBD and viral receptor (Li et al., 2005) , and performed an 177 ELISA to test binding ability of the above mAbs to these mutant proteins. In addition, control mAb 33G4 only blocked SARS-CoV 201 RBD, but not SARS-CoV-2 RBD, binding to the ACE2 receptor (Fig. 4B, C) , partially 202 explaining why this mAb did not neutralize SARS-CoV-2 infection. 203 Moreover, the two cross-neutralizing mAbs, 18F3 and 7B11, respectively recognized 227 two conserved, as well as several non-conserved, neutralizing epitopes on the RBDs of 228 SARS-CoV and SARS-CoV-2. 318 Characterization of the receptor-binding domain (RBD) of 2019 novel 319 coronavirus: implication for development of RBD protein as a viral attachment 320 inhibitor and vaccine (B) Inhibition of SARS-CoV RBD-specific mAbs for 411 the binding of SARS-CoV or SARS-CoV-2 RBD to ACE2 receptor by flow 412 cytometry analysis.	./cache/cord-275624-o5545c1x.txt	./txt/cord-275624-o5545c1x.txt