id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260735-3c33r1os	Spisakova, Martina	Ethacrynic and α-lipoic acids inhibit vaccinia virus late gene expression	2008-12-04		.txt	text/plain	8161	441	56	In this paper, we report an original finding that two redox-modulating agents, the ethacrynic and α-lipoic acids (EA, LA), inhibit growth of vaccinia virus (VACV) in vitro. Therefore, we have first compared the effect of different redox-modulating agents on the growth of VACV, characterized by activity of luciferase expressed by a rVACV. HeLa G cells were infected with a rVACV expressing luciferase under control of a VACV late promoter p4b (Luc L; The results indicated that all tested concentrations of ␤mercapthoethanol, dithiothreitol and l-ascorbic acid significantly increased luciferase activity expressed by rVACV (500 M concentration of these agents increased luciferase activity to 150, 140, and 120% of the mock-treated controls; p < 0.05). In contrast to EA and LA, none of these agents inhibited VACV growth in HeLa G cells characterized by activity of the reporter luciferase expressed by a rVACV.	./cache/cord-260735-3c33r1os.txt	./txt/cord-260735-3c33r1os.txt