id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254201-hqijd268	Bray, Mike	Radiolabeled antiviral drugs and antibodies as virus-specific imaging probes	2010-08-13		.txt	text/plain	10278	469	45	Such drugs and antibodies can therefore be thought of as probes for the detection of viral infections, suggesting that they might be used as radiolabeled tracers to visualize sites of viral replication by single-photon emission computed tomography (SPECT) or positron emission tomography (PET) imaging. The only instance in which a pathogen-specific tracer has been employed to detect and track a virus has been the use of a radiolabeled thymidine analogue to image herpes simplex virus (HSV) infections, based on phosphorylation of the probe by the viral thymidine kinase (TK), which traps it within infected cells (Fig. 2) (Brader et al., 2009; Kuruppu et al., 2007) . However, although compounds that inhibit methylation by blocking the host cell enzyme, S-adenosylhomocyteine hydrolase, have potent broad-spectrum antiviral activity, they would not be suitable as virus-specific probes, because they do not bind to a viral target.	./cache/cord-254201-hqijd268.txt	./txt/cord-254201-hqijd268.txt