id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-008761-b36x05fn	Billiau, A.	The interferon system as a basis for antiviral therapy or prophylaxis	2012-02-26		.txt	text/plain	2464	127	45	Possessing satisfactory answers to these questions is essential, not only to understand the natural role of the interferon system in virus disease but also to assess possible applications in medicine, in particular the use of interferons or interferoninducing substances as antiviral drugs. Interferon prepared from mouse cell lines infected with Newcastle disease virus is a mixture of a and B (6) . The main difference between these products and their natural-source-derived counterparts is that they contain only a single subtype, namely a2' While it is known that different subtypes of HuIFN-~ may differ in their antiviral potency depending on the cells on which they are tested, it is not yet known whether this has any repercussion for the clinical effects. Although these side-chains do not playa significant role in the effects of the IFN-S on cells, the pharmacokinetic behavior of this rDd-IFN-S was found to be rather different from that of natural fibroblast-derived interferon (8) .	./cache/cord-008761-b36x05fn.txt	./txt/cord-008761-b36x05fn.txt