id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318876-m1v0ij84	Spagnolo, Primavera A.	Sex and Gender Differences in Health: What the COVID-19 Pandemic Can Teach Us	2020-05-08		.txt	text/plain	1245	56	39	The authors of this commentary call for sexand gender-specific and differentiating factors to be urgently included in the research, prevention, and therapeutics implementation response to the coronavirus disease 2019 pandemic. We call for sex-and gender-specific and differentiating factors to be urgently included in the research, prevention, and therapeutics implementation response to the coronavirus disease 2019 (COVID-19) pandemic. Or we can investigate a priori the specific role of these factors and potentially leverage the mechanisms implicated in sex and gender differences in COVID-19 risk, progression, and outcomes, to identify effective prevention and treatment interventions for the entire population. Investigating sex hormone-influenced mechanisms and, more broadly, conducting sex-and genderinformed research may optimize the development of novel therapeutics and shed light on drug efficacy, safety profiles, and adherence to treatments currently tested for COVID-19, given that sex differences in pharmacokinetics and pharmacodynamics influence therapeutic effects and risk profiles of numerous medications, and that gender-related factors affect adherence to treatment, access to health care, and health-seeking behaviors (3) .	./cache/cord-318876-m1v0ij84.txt	./txt/cord-318876-m1v0ij84.txt