id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-029136-mbqncen1	De Pascale, Gennaro	Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections	2020-07-13		.txt	text/plain	3984	202	47	Critically ill adult patients were considered eligible for the study when the attending physician prescribed TGC as empirical treatment (within 12 h from microbiological sampling) of a possible MDR infection, or as targeted therapy based on definitive results, in the absence of any exclusion criteria: known TGC allergy, creatinine clearance less than 40 mL/min (calculated according to the Cocrockft-Gault formula) apart from those ones who were anuric and on continuous renal replacement therapy (CRRT), hyperbilirubinemia (bilirubin level higher than 3 mg/dL), severe hepatic failure (Child-Pugh C), little chance of survival as defined by the Simplified Acute Physiology 2 (SAPS 2) score > 80, concomitant treatment with other drugs that can potentially interfere with TGC (i.e., rifampin and cyclosporine). Our study is the first investigation where not only plasmatic but also pulmonary tigecycline concentrations are investigated during the treatment of severe infections in critically ill patients with high-dose TGC.	./cache/cord-029136-mbqncen1.txt	./txt/cord-029136-mbqncen1.txt