id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-009600-sb1pgqi8	Ospina-Tascón, Gustavo A.	Diastolic shock index and clinical outcomes in patients with septic shock	2020-04-16		.txt	text/plain	5223	247	44	Thus, we evaluated the relationships between very early HR:DAP ratios (i.e., the diastolic shock index, or DSI, calculated just before or at the start of vasopressor support) and clinical outcomes in patients with septic shock, hypothesizing that very early DSI values could promptly identify patients at high risk of unfavorable outcomes, while persistence of high DSI during the first hours of resuscitation could reflect more severe cardiovascular dysfunction. Our study retrieves four important findings: (a) progressively higher DSI values calculated just before or at the start of vasopressors are associated with a gradual increase in the risk of death in patients with septic shock; (b) isolated low DAP or high HR values do not clearly identify such risk; (c) non-survivors evolve with persistently high DSI values while requiring higher doses of vasopressors and more resuscitation fluids than survivors; (d) Pre-VPs/DSI and VPs/DSI showed similar performance to SOFA score and initial lactate levels to predict mortality, while mean arterial pressure and systolic shock index did not.	./cache/cord-009600-sb1pgqi8.txt	./txt/cord-009600-sb1pgqi8.txt