id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-311372-g34gquid	Zmijewski, Jaroslaw W.	Human Leukocyte Antigen-DR Deficiency and Immunosuppression-Related End-Organ Failure in Severe Acute Respiratory Syndrome Coronavirus 2 Infection	2020-07-20		.txt	text/plain	1639	91	33	D espite remarkable progress in understanding the immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), optimal management of immune function during severe viral infections remains a major issue among critically ill patients. Since the first description of role of HLA-DR in immunosuppression, 5 HLA-DR expression on monocytes has been subsequently proven to be a reliable marker for evaluating immune dysfunction and risk of secondary bacterial infections in sepsis and trauma patients. 10 Subsequent studies have recently confirmed that immune dysregulation in COVID-19 patients with respiratory failure is associated with a significant downregulation of monocyte HLA-DR. [13] [14] [15] Such inflammatory mechanisms can be relevant in the development of immunosuppression in sepsis survivors, consistent with reduced Human Leukocyte Antigen-DR Deficiency and Immunosuppression-Related End-Organ Failure in Severe Acute Respiratory Syndrome Coronavirus 2 Infection HLA-DR expression on monocytes after an initial activation of immune cells during sepsis syndrome.	./cache/cord-311372-g34gquid.txt	./txt/cord-311372-g34gquid.txt