id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-254266-6ca2d79d	Loftus, Randy W.	In Response: "Perioperative COVID-19 Defense: An Evidence-Based Approach for Optimization of Infection Control and Operating Room Management"	2020-04-20		.txt	text/plain	1128	85	49	[3] [4] [5] We evaluated the impact of an evidence-based, multifaceted approach on perioperative Staphylococcus aureus transmission and surgical-site infections (SSIs) in a randomized clinical trial. 7 Povidone-iodine has rapid and effective virucidal activity against the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA) with at least a 4 log 10 (99.99%) inactivation of both pathogens within 15 seconds. While chlorhexidine gluconate is less effective than povidone-iodine, 8 it has activity against enveloped viruses on skin and in the oral cavity (0.12%) with viral inactivation in as little as 30 seconds. 7, 8, 11, 12, 15 In conclusion, the evidence shows a favorable risk/benefit profile for our recommendation of patient decolonization with nasal povidone and oral chlorhexidine rinse to help mitigate the perioperative spread of COVID-19.	./cache/cord-254266-6ca2d79d.txt	./txt/cord-254266-6ca2d79d.txt