id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312861-6ayidmj3	Rayner, Craig R.	Accelerating Clinical Evaluation of Repurposed Combination Therapies for COVID-19	2020-08-21		.txt	text/plain	1999	115	30	As the global COVID-19 pandemic continues, unabated and clinical trials demonstrate limited effective pharmaceutical interventions, there is a pressing need to accelerate treatment evaluations. As the global COVID-19 pandemic continues, unabated and clinical trials demonstrate limited effective pharmaceutical interventions, there is a pressing need to accelerate treatment evaluations. We describe a clinical evaluation strategy using adaptive combination platform trials to rapidly test combination therapies to treat COVID-19. We describe a clinical evaluation strategy using adaptive combination platform trials to rapidly test combination therapies to treat COVID-19. Instead of sequentially testing monotherapies that will likely have modest clinical effects on their own, additive or synergistic effects can potentially be gained by combining antiviral drugs exploiting pharmacology throughout the spectrum of COVID-19 illness. 5, 6 This low success rate might be due to the fact that the majority of COVID-19 clinical trials (87%) are evaluating repurposed drugs as monotherapy.	./cache/cord-312861-6ayidmj3.txt	./txt/cord-312861-6ayidmj3.txt