id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253459-tcn10pho	Moreau, Gregory Brett	Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection	2020-07-28		.txt	text/plain	2377	154	58	4 A transgenic mouse model to study SARS-CoV-1 infection was developed that expresses the hACE2 gene under the control of the human cytokeratin 18 promoter. To investigate the potential of this transgenic mouse strain as a model for COVID-19 infection, five K18-hACE2 mice were intranasally inoculated with 8 × 10 4 Median Tissue Culture Infectious Dose (TCID50) of SARS-CoV-2, and five mice were mock-infected with sterile Dulbecco's Modified Eagle's Medium (DMEM). In the mouse model expressing hACE2 under the mouse ACE2 promoter, infected mice did not exhibit any clinical symptoms other than maximal weight loss on day 3 postinfection, and those mice recovered. 10 In contrast to these models, in which mice exhibited mild symptoms and recovered, only 60% of the mice survived past day 5 in the mouse strain expressing hACE2 under the lung ciliated epithelial cell HFH4 promoter.	./cache/cord-253459-tcn10pho.txt	./txt/cord-253459-tcn10pho.txt