id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-344120-7t5ce2hb	Baroutjian, Amanda	SARS-CoV-2 pharmacologic therapies and their safety/effectiveness according to level of evidence	2020-09-01		.txt	text/plain	5264	336	53	CONCLUSION: According to level 1 evidence reviewed here, the most effective SARS-Co-V-2 pharmacologic treatments include remdesivir for mild to severe disease, and a triple regimen therapy consisting of lopinavir-ritonavir, ribavirin and interferon beta-1b for mild to moderate disease. 20 Another randomized controlled open-label trial in 199 hospitalized patients with confirmed SARS-CoV-2 with severe COVID-19 was done to compare the clinical effectiveness of lopinavir-ritonavir to standard care alone. According to the level 1 evidence reviewed here, the most effective treatments against SARS-CoV-2, measured by time to negative RT-PCR and time to clinical improvement, are remdesivir therapy and a triple medication regimen (lopinavir-ritonavir, ribavirin, and interferon beta-1b). First, in patients with severe COVID-19, treatment with lopinavir-ritonavir showed no significant difference in time to clinical improvement, mortality at day 28, or detectable viral load compared to standard care alone.	./cache/cord-344120-7t5ce2hb.txt	./txt/cord-344120-7t5ce2hb.txt