id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341527-03rh966o	Stockton, John	Dexmedetomidine and worsening hypoxemia in the setting of COVID-19: A case report	2020-05-27		.txt	text/plain	1165	71	48	Here, we report a case of dexmedetomidine use in the setting of worsening hypoxemia, whereby oxygenation improved and intubation was avoided. Well known pharmacologic properties of the drug, namely the lack of respiratory depression and its anti-delirium effects, as well as other possible physiologic effects, suggest potential benefit for patients being managed with a delayed intubation approach. If dexmedetomidine can improve compliance with non-invasive oxygen support (the current recommended first-line therapy) while promoting better oxygenation, it may also decrease the need for mechanical ventilation and thus improve mortality. While early intubation was the initial recommended strategy for COVID-19 hypoxemia, a large case series in the US as well as data coming out of Britain, China, and Italy suggests a high mortality for patients requiring invasive ventilation [2] . In this case, we believe dexmedetomidine helped one patient avoid mechanical ventilation by improving compliance with non-invasive ventilation and promoting better oxygenation.	./cache/cord-341527-03rh966o.txt	./txt/cord-341527-03rh966o.txt