id author title date pages extension mime words sentences flesch summary cache txt cord-322887-md446f9p Carver, Catherine Cardiac injury and ARDS meta-analysis validity – Correspondence in response to Santoso et al. 2020-06-27 .txt text/plain 540 28 55 This paper was of note to us because it included a meta-analysis on acute respiratory distress syndrome (ARDS) and cardiac injury, based on two papers -one by Shi (2) and another by Wu (3). On reading the paper by Wu, we have significant concerns about the inclusion of this study in Santoso's meta-analysis as we believe it currently underpins an inaccurate conclusion that cardiac injury is not significantly associated with increased risk of ARDS in COVID-19 by Santoso. However, from what we currently have access to, it seems most likely that Santoso's meta-analysis for ARDS has been based on composite endpoint data. Moreover, the conclusion of Santoso runs counter to Shi's JAMA Cardiology paper, which was the other paper included in Santoso's meta-analysis, which did report on purely ARDS cases and cardiac injury and did find a statistically significant association. Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis ./cache/cord-322887-md446f9p.txt ./txt/cord-322887-md446f9p.txt