id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-317784-fl9zbgad	Senthilkumaran, Subramanian	Propofol in COVID 19 — From basic science to clinical impact	2020-07-09		.txt	text/plain	454	31	41	However, recently [3] it was demonstrated that propofol infusion increases ACE2 mediated conversion of angiotensin II to angiotensin, which results in a fall in angiotensin II levels and an elevation of angiotensin 1 to7; and these exhibit protective effects of lungs by way of recovery of endothelial cell function via an up-regulation of ACE2-Ang -Mas axis, subsequent to phosphorylation of endothelial nitric oxide (NO) synthase to generate NO, and regulation of apoptosis-related protein such as bcl-2, caspase9. Propofol prevents human umbilical vein endothelial cell injury from ang II-induced apoptosis by activating the ACE2-(1-7)-Mas axis and eNOS phosphorylation Propofol stimulates nitric oxide release from cultured porcine aortic endothelial cells Effects of propofol on endothelial cells subjected to a peroxynitrite donor Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats	./cache/cord-317784-fl9zbgad.txt	./txt/cord-317784-fl9zbgad.txt