id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329011-spiuqngp	Huang, Yuan	Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19	2020-08-03		.txt	text/plain	6045	340	53	The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. A large number of glycosylated S proteins cover the surface of SARS-CoV-2 and bind to the host cell receptor angiotensinconverting enzyme 2 (ACE2), mediating viral cell entry [8] . The SARS-CoV-2 S protein is highly conserved among all human coronaviruses (HCoVs) and is involved in receptor recognition, viral attachment, and entry into host cells. Structure of the S1 subunit The binding of virus particles to cell receptors on the surface of the host cell is the initiation of virus infection; therefore, receptor recognition is an important determinant of viral entry and a drug design target. Therefore, the development of antibodies targeting this functional motif may cross-bind and neutralize these two viruses and related CoVs. Antiviral peptides prevent SARS-CoV-2 membrane fusion and can potentially be used for the prevention and treatment of infection.	./cache/cord-329011-spiuqngp.txt	./txt/cord-329011-spiuqngp.txt